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Jan Holmgren

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Jan Holmgren; Anna Lundgren; Erik Nygren; L Bourgeois; N Carlin; J Clements; B Gustafsson; J Tobias; R Walker; Ann-Mari Svennerholm
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant.
Louise Sjökvist Ottsjö; John Clements; Carl-Fredrik Flach; Jan Holmgren; Sukanya Raghavan
A Double Mutant Heat-Labile Toxin from Escherichia coli, LT(R192G/L211A), Is an Effective Mucosal Adjuvant for Vaccination against Helicobacter pylori Infection.
Anna Lundgren; J Tobias; R Walker; L Bourgeois; N Carlin; B Gustafsson; Jan Holmgren; Marianne Jertborn; S Leach; Ann-Mari Svennerholm
Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein.

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All Publications

2013: Jan Holmgren; Anna Lundgren; Erik Nygren; L Bourgeois; N Carlin; J Clements; B Gustafsson; J Tobias; R Walker; Ann-Mari Svennerholm
Development and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvant.
Vaccine 2013;31(20):2457-64.
2013: Louise Sjökvist Ottsjö; John Clements; Carl-Fredrik Flach; Jan Holmgren; Sukanya Raghavan
A Double Mutant Heat-Labile Toxin from Escherichia coli, LT(R192G/L211A), Is an Effective Mucosal Adjuvant for Vaccination against Helicobacter pylori Infection.
Infection and immunity 2013;81(5):1532-40.
2013: Anna Lundgren; J Tobias; R Walker; L Bourgeois; N Carlin; B Gustafsson; Jan Holmgren; Marianne Jertborn; S Leach; Ann-Mari Svennerholm
Clinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid protein.
Vaccine 2013;31(8):1163-70.
2012: Jan Holmgren
A case for control of cholera in Africa by vaccination.
The Lancet infectious diseases 2012;12(11):818-9.
2012: Jan Holmgren; Ann-Mari Svennerholm
Vaccines against mucosal infections.
Current opinion in immunology 2012;24(3):343-53.
2012: Carl-Fredrik Flach; Jan Holmgren; Michael Mozer; Malin Sundquist; Sukanya Raghavan
Mucosal vaccination increases local chemokine production attracting immune cells to the stomach mucosa of Helicobacter pylori infected mice.
Vaccine 2012;30(9):1636-43.
2012: Jia-Bin Sun; Cecil Czerkinsky; Jan Holmgren
B lymphocytes treated in vitro with antigen coupled to cholera toxin B subunit induce antigen-specific Foxp3(+) regulatory T cells and protect against experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(4):1686-97.
2011: Joshua Tobias; Nils I A Carlin; Michael Lebens; Ann-Mari Svennerholm; Jan Holmgren
Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice.
Vaccine 2011;29(48):8863-9.
2011: Michael Lebens; Erik Nygren; Margareta Blomquist; Agneta Ekman; Susanne Källgård; Stefan L Karlsson; Jan Holmgren
Construction of novel vaccine strains of Vibrio cholerae co-expressing the Inaba and Ogawa serotype antigens.
Vaccine 2011;29(43):7505-13.
2011: Dipika Sur; Thu Van Nguyen; Mohammad Ali; Stephen Attridge; Sujit K Bhattacharya; Rodney Carbis; John D Clemens; Jacqueline L Deen; Allan Donner; Nirmal K Ganguly; Seung Hyun Han; Jan Holmgren; Suman Kanungo; Deok Ryun Kim; Byomkesh Manna; G Balakrish Nair; Swapan Kumar Niyogi; Allison M Paisley; Jin Kyung Park; Mahesh K Puri; Raman Rao; Binod Sah; Banawarilal Sarkar; Anna Lena Lopez
Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial.
PLoS neglected tropical diseases 2011;5(10):e1289.
2011: Petra Henning; Jan Holmgren; Yeu-Jiann Hua; Leif Lindholm; Anna Strömbeck; Carl-Fredrik Flach; Tobias Gustafsson; Ulf Yrlid
The subcellular location of antigen expressed by adenoviral vectors modifies adaptive immunity but not dependency on cross-presenting dendritic cells.
European journal of immunology 2011;41(8):2185-96.
2011: Åsa Lindgren; Cheol-heui YUN; Åsa Sjöling; Camilla Berggren; Jia-Bin Sun; Erik Jonsson; Jan Holmgren; Ann-Mari Svennerholm; Samuel B Lundin
Impaired IFN-γ production after stimulation with bacterial components by natural killer cells from gastric cancer patients.
Experimental cell research 2011;317(6):849-58.
2011: Joaquin Sanchez; Jan Holmgren
Cholera toxin - a foe & a friend.
The Indian journal of medical research 2011;133():153-63.
2011: Carl-Fredrik Flach; Natascha Svensson; Margareta Blomquist; Agneta Ekman; Sukanya Raghavan; Jan Holmgren
A truncated form of HpaA is a promising antigen for use in a vaccine against Helicobacter pylori.
Vaccine 2011;29(6):1235-41.
2011: Cecil Czerkinsky; Nicolas Cuburu; Mi-Na Kweon; Fabienne Anjuere; Jan Holmgren
Sublingual vaccination.
Human vaccines 2011;7(1):110-4.
2010: Joshua Tobias; Jan Holmgren; Maria Hellman; Erik Nygren; Michael Lebens; Ann-Mari Svennerholm
Over-expression of major colonization factors of enterotoxigenic Escherichia coli, alone or together, on non-toxigenic E. coli bacteria.
Vaccine 2010;28(43):6977-84.
2010: Sukanya Raghavan; Anna Karin Ostberg; Carl-Fredrik Flach; Agneta Ekman; Margareta Blomquist; Cecil Czerkinsky; Jan Holmgren
Sublingual immunization protects against Helicobacter pylori infection and induces T and B cell responses in the stomach.
Infection and immunity 2010;78(10):4251-60.
2010: Joshua Tobias; Ann-Mari Svennerholm; Jan Holmgren; Michael Lebens
Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines.
Applied microbiology and biotechnology 2010;87(4):1355-65.
2010: Jia-Bin Sun; Cecil Czerkinsky; Jan Holmgren
Mucosally induced immunological tolerance, regulatory T cells and the adjuvant effect by cholera toxin B subunit.
Scandinavian journal of immunology 2010;71(1):1-11.
2009: Nicolas Cuburu; Mi-Na Kweon; Catherine Hervouet; Hye-Ran Cha; Yuk-Ying S Pang; Jan Holmgren; Konrad Stadler; John T Schiller; Fabienne Anjuère; Cecil Czerkinsky
Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infection.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7851-9.
2009: Stephen R Attridge; Jan Holmgren
Vibrio cholerae O139 capsular polysaccharide confers complement resistance in the absence or presence of antibody yet presents a productive target for cell lysis: implications for detection of bactericidal antibodies.
Microbial pathogenesis 2009;47(6):314-20.
2009: Suman Kanungo; Allison Paisley; Anna Lena Lopez; Mihir Bhattacharya; Byomkesh Manna; Deok Ryun Kim; Seung Hyun Han; Stephen Attridge; Rodney Carbis; Raman Rao; Jan Holmgren; John D Clemens; Dipika Sur
Immune responses following one and two doses of the reformulated, bivalent, killed, whole-cell, oral cholera vaccine among adults and children in Kolkata, India: a randomized, placebo-controlled trial.
Vaccine 2009;27(49):6887-93.
2009: Dipika Sur; Anna Lena Lopez; Suman Kanungo; Allison Paisley; Byomkesh Manna; Mohammad Ali; Swapan Kumar Niyogi; Jin Kyung Park; Banawarilal Sarkar; Mahesh K Puri; Deok Ryun Kim; Jacqueline L Deen; Jan Holmgren; Rodney Carbis; Raman Rao; Thu Van Nguyen; Allan Donner; Nirmal K Ganguly; G Balakrish Nair; Sujit K Bhattacharya; John D Clemens
Efficacy and safety of a modified killed-whole-cell oral cholera vaccine in India: an interim analysis of a cluster-randomised, double-blind, placebo-controlled trial.
Lancet 2009;374(9702):1694-702.
2009: Linda Fahlén-Yrlid; Tobias Gustafsson; Jessica Westlund; Anna Holmberg; Anna Strömbeck; Margareta Blomquist; G Gordon MacPherson; Jan Holmgren; Ulf Yrlid
CD11c(high )dendritic cells are essential for activation of CD4+ T cells and generation of specific antibodies following mucosal immunization.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5032-41.
2009: Erik Nygren; Bin-Ling Li; Jan Holmgren; Stephen R Attridge
Establishment of an adult mouse model for direct evaluation of the efficacy of vaccines against Vibrio cholerae.
Infection and immunity 2009;77(8):3475-84.
2009: Sohel Shamsuzzaman; Tanvir Ahmed; Kaiissar Mannoor; Yasmin Ara Begum; PK Bardhan; RICHARD SACK; David A Sack; Ann-Mari Svennerholm; Jan Holmgren; Firdausi Qadri
Robust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responses.
Vaccine 2009;27(9):1386-92.
2009: Stephen R Attridge; Gun Wallerström; Bin-Ling Li; R Morona; Jan Holmgren
Differential immunogenicity of Vibrio cholerae O139 variants expressing different combinations of naturally occurring and atypical forms of the serogroup polysaccharide.
Vaccine 2009;27(7):1055-61.
2008: Jia-Bin Sun; Carl-Fredrik Flach; Cecil Czerkinsky; Jan Holmgren
B lymphocytes promote expansion of regulatory T cells in oral tolerance: powerful induction by antigen coupled to cholera toxin B subunit.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8278-87.
2008: Erik Nygren; Jan Holmgren; Stephen R Attridge
Murine antibody responses following systemic or mucosal immunization with viable or inactivated Vibrio cholerae.
Vaccine 2008;26(52):6784-90.
2008: Salma Nowroozalizadeh; Marianne Jansson; Jenni Adamsson; Marianne Lindblad; Eva Maria Fenyö; Jan Holmgren; Ali M Harandi
Suppression of HIV replication in vitro by CpG and CpG conjugated to the non toxic B subunit of cholera toxin.
Current HIV research 2008;6(3):230-8.
2008: Dilip Mahalanabis; Anna Lena Lopez; Dipika Sur; Jacqueline L Deen; Byomkesh Manna; Suman Kanungo; Lorenz Von Seidlein; Rodney Carbis; Seung Hyun Han; Seong Hye Shin; Stephen Attridge; Raman Rao; Jan Holmgren; John Clemens; Sujit K Bhattacharya
A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India.
PloS one 2008;3(6):e2323.
2008: Mohammad Ali; Michael Emch; Mohammad Yunus; David A Sack; Anna Lena Lopez; Jan Holmgren; John Clemens
Vaccine Protection of Bangladeshi infants and young children against cholera: implications for vaccine deployment and person-to-person transmission.
The Pediatric infectious disease journal 2008;27(1):33-7.
2007: Nicolas Cuburu; Mi-Na Kweon; Joo-Hye Song; Catherine Hervouet; Carmelo Luci; Jia-Bin Sun; Paul Hofman; Jan Holmgren; Fabienne Anjuère; Cecil Czerkinsky
Sublingual immunization induces broad-based systemic and mucosal immune responses in mice.
Vaccine 2007;25(51):8598-610.
2007: Vu Dinh Thiem; Do Gia Canh; Dang Duc Anh; Jacqueline L Deen; Lorenz Von Seidlein; John D Clemens; Jan Holmgren
Response to "questionable merits of the field trial of an oral killed whole cell cholera vaccine in Vietnam during 1998-2003" Vaccine 2007;25(8):1353-4.
Vaccine 2007;25(47):7981-3.
2007: Jia-Bin Sun; Cecil Czerkinsky; Jan Holmgren
Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells.
Scandinavian journal of immunology 2007;66(2-3):278-86.
2007: Carl-Fredrik Flach; Firdausi Qadri; Taufiqur R Bhuiyan; Nur Haque Alam; Eva Jennische; Jan Holmgren; Ivar Lönnroth
Differential expression of intestinal membrane transporters in cholera patients.
FEBS letters 2007;581(17):3183-8.
2007: Carl-Fredrik Flach; Firdausi Qadri; Taufiqur R Bhuiyan; Nur Haque Alam; Eva Jennische; Ivar Lönnroth; Jan Holmgren
Broad up-regulation of innate defense factors during acute cholera.
Infection and immunity 2007;75(5):2343-50.
2007: Dang Duc Anh; Do Gia Canh; Anna Lena Lopez; Vu Dinh Thiem; Phan Thi Long; Nguyen Hong Son; Jacqueline L Deen; Lorenz Von Seidlein; Rodney Carbis; Seung Hyun Han; Seong Hye Shin; Stephen Attridge; Jan Holmgren; John Clemens
Safety and immunogenicity of a reformulated Vietnamese bivalent killed, whole-cell, oral cholera vaccine in adults.
Vaccine 2007;25(6):1149-55.
2006: Jia-Bin Sun; Sukanya Raghavan; Asa Sjöling; Samuel Lundin; Jan Holmgren
Oral tolerance induction with antigen conjugated to cholera toxin B subunit generates both Foxp3+CD25+ and Foxp3-CD25- CD4+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7634-44.
2006: G Balakrish Nair; Firdausi Qadri; Jan Holmgren; Ann-Mari Svennerholm; Ashrafus Safa; Nurul A Bhuiyan; Qazi Shafi Ahmad; Shah M Faruque; A S G Faruque; Yoshifumi Takeda; David A Sack
Cholera due to altered El Tor strains of Vibrio cholerae O1 in Bangladesh.
Journal of clinical microbiology 2006;44(11):4211-3.
2006: Jia-Bin Sun; Nicolas Cuburu; M Blomquist; Bin-Ling Li; Cecil Czerkinsky; Jan Holmgren
Sublingual tolerance induction with antigen conjugated to cholera toxin B subunit induces Foxp3+CD25+CD4+ regulatory T cells and suppresses delayed-type hypersensitivity reactions.
Scandinavian journal of immunology 2006;64(3):251-9.
2006: Annie George Chandy; Susanne Hultkrantz; Sukanya Raghavan; Cecil Czerkinsky; Michael Lebens; Esbjörn Telemo; Jan Holmgren
Oral tolerance induction by mucosal administration of cholera toxin B-coupled antigen involves T-cell proliferation in vivo and is not affected by depletion of CD25+ T cells.
Immunology 2006;118(3):311-20.
2006: Vu Dinh Thiem; Jacqueline L Deen; Lorenz Von Seidlein; Do Gia Canh; Dang Duc Anh; Jin-Kyung Park; Mohammad Ali; M Carolina Danovaro-Holliday; Nguyen Dinh Son; Nguyen Thai Hoa; Jan Holmgren; John D Clemens
Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam.
Vaccine 2006;24(20):4297-303.
2006: Iain Stephenson; Maria C Zambon; Anna Rudin; Anthony Colegate; Audino Podda; Roberto Bugarini; Giuseppe Del Giudice; Ada Minutello; Susan Bonnington; Jan Holmgren; Kingston H G Mills; Karl G Nicholson
Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers.
Journal of virology 2006;80(10):4962-70.
2006: Jenni Adamsson; Marianne Lindblad; Annika Lundqvist; Denise Kelly; Jan Holmgren; Ali M Harandi
Novel immunostimulatory agent based on CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4902-13.
2006: Ali M Harandi; Jan Holmgren
CpG oligodeoxynucleotides and mobilization of innate mucosal immunity: tasks and tactics.
Vaccine 2006;24 Suppl 2():S2-48-9.
2006: Carmelo Luci; Catherine Hervouet; Déborah Rousseau; Jan Holmgren; Cecil Czerkinsky; Fabienne Anjuère
Dendritic cell-mediated induction of mucosal cytotoxic responses following intravaginal immunization with the nontoxic B subunit of cholera toxin.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):2749-57.
2005: Sara Tengvall; Agnetha Josefsson; Jan Holmgren; Ali M Harandi
CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice.
Journal of reproductive immunology 2005;68(1-2):53-69.
2005: Carl-Fredrik Flach; Stefan Lange; Eva Jennische; Ivar Lönnroth; Jan Holmgren
Cholera toxin induces a transient depletion of CD8+ intraepithelial lymphocytes in the rat small intestine as detected by microarray and immunohistochemistry.
Infection and immunity 2005;73(9):5595-602.
2005: Joaquín Sánchez; Jan Holmgren
Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea.
Current opinion in immunology 2005;17(4):388-98.
2005: Mohammad Ali; Michael Emch; Lorenz Von Seidlein; Mohammad Yunus; David A Sack; Malla Rao; Jan Holmgren; John D Clemens
Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis.
Lancet 2005;366(9479):44-9.
2005: Sukanya Raghavan; Jan Holmgren
CD4+CD25+ suppressor T cells regulate pathogen induced inflammation and disease.
FEMS immunology and medical microbiology 2005;44(2):121-7.
2005: Jan Holmgren; Cecil Czerkinsky
Mucosal immunity and vaccines.
Nature medicine 2005;11(4 Suppl):S45-53.
2005: Jan Holmgren; Jenni Adamsson; Fabienne Anjuère; John Clemens; Cecil Czerkinsky; Kristina Eriksson; Carl-Fredrik Flach; Annie George Chandy; Ali M Harandi; Michael Lebens; Thomas Lehner; Marianne Lindblad; Erik Nygren; Sukanya Raghavan; Joaquin Sanchez; Michael Stanford; Jia-Bin Sun; Ann-Mari Svennerholm; Sara Tengvall
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA.
Immunology letters 2005;97(2):181-8.
2005: Cheol-heui YUN; Anna Lundgren; Josef Azem; Asa Sjöling; Jan Holmgren; Ann-Mari Svennerholm; B Samuel Lundin
Natural killer cells and Helicobacter pylori infection: bacterial antigens and interleukin-12 act synergistically to induce gamma interferon production.
Infection and immunity 2005;73(3):1482-90.
2004: Fabienne Anjuère; Carmelo Luci; Michael Lebens; Déborah Rousseau; Catherine Hervouet; Geneviève Milon; Jan Holmgren; Carlos Ardavin; Cecil Czerkinsky
In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5103-11.
2004: Sukanya Raghavan; Elisabeth Suri-Payer; Jan Holmgren
Antigen-specific in vitro suppression of murine Helicobacter pylori-reactive immunopathological T cells by CD4CD25 regulatory T cells.
Scandinavian journal of immunology 2004;60(1-2):82-8.
2004: Jia-Bin Sun; Kristina Eriksson; Bin-Ling Li; Marianne Lindblad; Josef Azem; Jan Holmgren
Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells.
Clinical immunology (Orlando, Fla.) 2004;112(1):35-44.
2004: Michael Stanford; Trevor Whittall; Lesley A Bergmeier; Marianne Lindblad; S Lundin; Thomas Shinnick; Yutaka Mizushima; Jan Holmgren; Thomas Lehner
Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease.
Clinical and experimental immunology 2004;137(1):201-8.
2004: John Clemens; Stephen J Savarino; Remon Abu-Elyazeed; Mohammed Safwat; Malla Rao; Thomas F Wierzba; Ann-Mari Svennerholm; Jan Holmgren; Robert W Frenck; Eunsik Park; Abdollah B Naficy
Development of pathogenicity-driven definitions of outcomes for a field trial of a killed oral vaccine against enterotoxigenic Escherichia coli in Egypt: application of an evidence-based method.
The Journal of infectious diseases 2004;189(12):2299-307.
2004: Michael Lebens; Jia-Bin Sun; Cecil Czerkinsky; Jan Holmgren
Current status and future prospects for a vaccine against schistosomiasis.
Expert review of vaccines 2004;3(3):315-28.
2004: Kristina Eriksson; Jia-Bin Sun; Inger Nordström; Margareta Fredriksson; Marianne Lindblad; Bin-Ling Li; Jan Holmgren
Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model tumor.
European journal of immunology 2004;34(5):1272-81.
2004: Joaquín Sánchez; Gerardo Medina; Thomas Buhse; Jan Holmgren; Gloria Soberón-Chavez
Expression of cholera toxin under non-AKI conditions in Vibrio cholerae El Tor induced by increasing the exposed surface of cultures.
Journal of bacteriology 2004;186(5):1355-61.
2004: Ali M Harandi; Jan Holmgren
CpG DNA as a potent inducer of mucosal immunity: implications for immunoprophylaxis and immunotherapy of mucosal infections.
Current opinion in investigational drugs (London, England : 2000) 2004;5(2):141-5.
2003: Sukanya Raghavan; Johanna Nyström; Margareta Fredriksson; Jan Holmgren; Ali M Harandi
Orally administered CpG oligodeoxynucleotide induces production of CXC and CC chemokines in the gastric mucosa and suppresses bacterial colonization in a mouse model of Helicobacter pylori infection.
Infection and immunity 2003;71(12):7014-22.
2003: Sukanya Raghavan; Margareta Fredriksson; Ann-Mari Svennerholm; Jan Holmgren; Elisabeth Suri-Payer
Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice.
Clinical and experimental immunology 2003;132(3):393-400.
2003: Jan Holmgren; Cecil Czerkinsky; Kristina Eriksson; Ali Mharandi
Mucosal immunisation and adjuvants: a brief overview of recent advances and challenges.
Vaccine 2003;21 Suppl 2():S89-95.
2003: Jan Holmgren; Ali M Harandi; Cecil Czerkinsky
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA.
Expert review of vaccines 2003;2(2):205-17.
2003: Kristina Eriksson; Margareta Fredriksson; Inger Nordström; Jan Holmgren
Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development.
Infection and immunity 2003;71(4):1740-7.
2003: Ali M Harandi; Joaquin Sanchez; Kristina Eriksson; Jan Holmgren
Recent developments in mucosal immunomodulatory adjuvants.
Current opinion in investigational drugs (London, England : 2000) 2003;4(2):156-61.
2003: Fabienne Anjuère; Annie George Chandy; Florence Audant; Déborah Rousseau; Jan Holmgren; Cecil Czerkinsky
Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1586-92.
2003: Michael Lebens; Jia-Bin Sun; Hamid Sadeghi; Malin Bäckström; Ida Olsson; Nathalie Mielcarek; Bin-Ling Li; Andre Capron; Cecil Czerkinsky; Jan Holmgren
A mucosally administered recombinant fusion protein vaccine against schistosomiasis protecting against immunopathology and infection.
Vaccine 2003;21(5-6):514-20.
2003: Thomas Lehner; Miles R Stanford; P A Phipps; J B Sun; B G Xiao; Jan Holmgren; Thomas Shinnick; Adam Hasan; Yutaka Mizushima
Immunopathogenesis and prevention of uveitis with the Behçet's disease-specific peptide linked to cholera toxin B.
Advances in experimental medicine and biology 2003;528():173-80.
2003: Paula A Phipps; Miles R Stanford; Jia-Bin Sun; Bao-Guo Xiao; Jan Holmgren; Thomas Shinnick; Adam Hasan; Yutaka Mizushima; Thomas Lehner
Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit.
European journal of immunology 2003;33(1):224-32.
2003: Ali M Harandi; Kristina Eriksson; Jan Holmgren
A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection.
Journal of virology 2003;77(2):953-62.
2002: Sukanya Raghavan; M Hjulström; Jan Holmgren; Ann-Mari Svennerholm
Protection against experimental Helicobacter pylori infection after immunization with inactivated H. pylori whole-cell vaccines.
Infection and immunity 2002;70(11):6383-8.
2002: Kristina Eriksson; Jan Holmgren
Recent advances in mucosal vaccines and adjuvants.
Current opinion in immunology 2002;14(5):666-72.
2002: Joaquín Sánchez; Gun Wallerström; Margareta Fredriksson; Jonas Angström; Jan Holmgren
Detoxification of cholera toxin without removal of its immunoadjuvanticity by the addition of (STa-related) peptides to the catalytic subunit. A potential new strategy to generate immunostimulants for vaccination.
The Journal of biological chemistry 2002;277(36):33369-77.
2002: Hector J Hernandez; Laura I Rutitzky; Mike Lebens; Jan Holmgren; Miguel J Stadecker
Diminished immunopathology in Schistosoma mansoni infection following intranasal administration of cholera toxin B-immunodominant peptide conjugate correlates with enhanced transforming growth factor-beta production by CD4 T cells.
Parasite immunology 2002;24(8):423-7.
2002: Sukanya Raghavan; Ann-Mari Svennerholm; Jan Holmgren
Effects of oral vaccination and immunomodulation by cholera toxin on experimental Helicobacter pylori infection, reinfection, and gastritis.
Infection and immunity 2002;70(8):4621-7.
2002: Hamid Sadeghi; Søren Bregenholt; Dale Wegmann; Jacob S Petersen; Jan Holmgren; Michael Lebens
Genetic fusion of human insulin B-chain to the B-subunit of cholera toxin enhances in vitro antigen presentation and induction of bystander suppression in vivo.
Immunology 2002;106(2):237-45.
2002: Dang Duc Trach; Phung Dac Cam; NT Ke; Malla Rao; D Dinh; P V Hang; N V Hung; Do Gia Canh; Vu Dinh Thiem; Abdollah B Naficy; Bernard Ivanoff; Ann-Mari Svennerholm; Jan Holmgren; John D Clemens
Investigations into the safety and immunogenicity of a killed oral cholera vaccine developed in Viet Nam.
Bulletin of the World Health Organization 2002;80(1):2-8.
2001: Ali M Harandi; Bo Svennerholm; Jan Holmgren; Kristina Eriksson
Protective vaccination against genital herpes simplex virus type 2 (HSV-2) infection in mice is associated with a rapid induction of local IFN-gamma-dependent RANTES production following a vaginal viral challenge.
American journal of reproductive immunology (New York, N.Y. : 1989) 2001;46(6):420-4.
2001: Eva-Liz Johansson; L Wassén; Jan Holmgren; Marianne Jertborn; Anna Rudin
Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans.
Infection and immunity 2001;69(12):7481-6.
2001: Jia-Bin Sun; Miguel J Stadecker; Nathalie Mielcarek; M Lakew; Bin-Ling Li; Hector J Hernandez; Cecil Czerkinsky; Jan Holmgren
Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice.
Scandinavian journal of immunology 2001;54(5):440-7.
2001: Marianne Quiding-Järbrink; Hans Lönroth; I Ahlstedt; Jan Holmgren; Ann-Mari Svennerholm
Human gastric B cell responses can be induced by intestinal immunisation.
Gut 2001;49(4):512-8.
2001: Annie George Chandy; Kristina Eriksson; Michael Lebens; Inger Nordström; E Schön; Jan Holmgren
Cholera toxin B subunit as a carrier molecule promotes antigen presentation and increases CD40 and CD86 expression on antigen-presenting cells.
Infection and immunity 2001;69(9):5716-25.
2001: Ali M Harandi; Bo Svennerholm; Jan Holmgren; Kristina Eriksson
Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity.
Journal of virology 2001;75(14):6705-9.
2001: Abdollah B Naficy; Dang Duc Trach; NT Ke; N T Chuc; ALAN SORKIN; Malla Rao; T H Sy; Vu Dinh Thiem; Do Gia Canh; Richard Mahoney; Jan Holmgren; Bernard Ivanoff; John D Clemens
Cost of immunization with a locally produced, oral cholera vaccine in Viet Nam.
Vaccine 2001;19(27):3720-5.
2001: Marianne Jertborn; Inger Nordström; Anders Kilander; Cecil Czerkinsky; Jan Holmgren
Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans.
Infection and immunity 2001;69(6):4125-8.
2001: Annie George Chandy; Nathalie Mielcarek; Inger Nordström; Jan Holmgren; Kristina Eriksson
Vaccination with Bordetella pertussis-pulsed autologous or heterologous dendritic cells induces a mucosal antibody response in vivo and protects against infection.
Infection and immunity 2001;69(6):4120-4.
2001: X Shen; Teresa Lagergård; Y Yang; Marianne Lindblad; Margareta Fredriksson; Gun Wallerström; Jan Holmgren
Effect of pre-existing immunity for systemic and mucosal immune responses to intranasal immunization with group B Streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate.
Vaccine 2001;19(25-26):3360-8.
2001: E Schön; Ali M Harandi; Inger Nordström; Jan Holmgren; Kristina Eriksson
Dendritic cell vaccination protects mice against lethality caused by genital herpes simplex virus type 2 infection.
Journal of reproductive immunology 2001;50(2):87-104.
2001: Ali M Harandi; Bo Svennerholm; Jan Holmgren; Kristina Eriksson
Differential roles of B cells and IFN-gamma-secreting CD4(+) T cells in innate and adaptive immune control of genital herpes simplex virus type 2 infection in mice.
The Journal of general virology 2001;82(Pt 4):845-53.
2001: Nathalie Mielcarek; Elisabeth Hultgren Hörnquist; Bengt R Johansson; C Locht; S N Abraham; Jan Holmgren
Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin.
Cellular microbiology 2001;3(3):181-8.
2001: Jia-Bin Sun; Bin-Ling Li; M Lakew; J M Grzych; Andre Capron; Cecil Czerkinsky; Jan Holmgren
Nasal administration of Schistosoma mansoni egg antigens-cholera toxin B subunit conjugate to infected mice reduces immunopathology and mortality.
Advances in experimental medicine and biology 2001;495():305-9.
2001: Bin-Ling Li; Jia-Bin Sun; Jan Holmgren
Adoptive transfer of mucosal T cells or dendritic cells from animals fed with cholera toxin B subunit alloantigen conjugate induces allogeneic T cell tolerance.
Advances in experimental medicine and biology 2001;495():271-5.
2001: X Shen; Teresa Lagergård; Y Yang; Marianne Lindblad; Margareta Fredriksson; Jan Holmgren
Group B Streptococcus capsular polysaccharide-cholera toxin B subunit conjugate vaccines prepared by different methods for intranasal immunization.
Infection and immunity 2001;69(1):297-306.
2000: X Shen; Teresa Lagergård; Y Yang; Marianne Lindblad; Margareta Fredriksson; Jan Holmgren
Preparation and preclinical evaluation of experimental group B streptococcus type III polysaccharide-cholera toxin B subunit conjugate vaccine for intranasal immunization.
Vaccine 2000;19(7-8):850-61.
2000: Jia-Bin Sun; Bin-Ling Li; Cecil Czerkinsky; Jan Holmgren
Enhanced immunological tolerance against allograft rejection by oral administration of allogeneic antigen linked to cholera toxin B subunit.
Clinical immunology (Orlando, Fla.) 2000;97(2):130-9.
2000: Jia-Bin Sun; B G Xiao; Marianne Lindblad; Bin-Ling Li; H Link; Cecil Czerkinsky; Jan Holmgren
Oral administration of cholera toxin B subunit conjugated to myelin basic protein protects against experimental autoimmune encephalomyelitis by inducing transforming growth factor-beta-secreting cells and suppressing chemokine expression.
International immunology 2000;12(10):1449-57.
2000: Firdausi Qadri; Muhammad Asaduzzaman; Christine Wennerås; G Mohi; M John Albert; M Abdus Salam; RICHARD SACK; M Jertborn; J R McGhee; David A Sack; Jan Holmgren
Enterotoxin-specific immunoglobulin E responses in humans after infection or vaccination with diarrhea-causing enteropathogens.
Infection and immunity 2000;68(10):6077-81.
2000: X Shen; Teresa Lagergård; Y Yang; Marianne Lindblad; Margareta Fredriksson; Jan Holmgren
Systemic and mucosal immune responses in mice after mucosal immunization with group B streptococcus type III capsular polysaccharide-cholera toxin B subunit conjugate vaccine.
Infection and immunity 2000;68(10):5749-55.
2000: Kristina Eriksson; Inger Nordström; Cecil Czerkinsky; Jan Holmgren
Differential effect of cholera toxin on CD45RA+ and CD45RO+ T cells: specific inhibition of cytokine production but not proliferation of human naive T cells.
Clinical and experimental immunology 2000;121(2):283-8.
2000: Carola Rask; Jan Holmgren; Margareta Fredriksson; Marianne Lindblad; Inger Nordström; Jia-Bin Sun; Cecil Czerkinsky
Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(7):1024-32.
2000: Carola Rask; Margareta Fredriksson; Marianne Lindblad; Cecil Czerkinsky; Jan Holmgren
Mucosal and systemic antibody responses after peroral or intranasal immunization: effects of conjugation to enterotoxin B subunits and/or of co-administration with free toxin as adjuvant.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2000;108(3):178-86.
2000: Jonas Angström; Malin Bäckström; A Berntsson; Niclas Karlsson; Jan Holmgren; Karl-Anders Karlsson; Michael Lebens; Susann Teneberg
Novel carbohydrate binding site recognizing blood group A and B determinants in a hybrid of cholera toxin and Escherichia coli heat-labile enterotoxin B-subunits.
The Journal of biological chemistry 2000;275(5):3231-8.
2000: Nathalie Mielcarek; Inger Nordström; F D Menozzi; C Locht; Jan Holmgren
Genital antibody responses in mice after intranasal infection with an attenuated candidate vector strain of Bordetella pertussis.
Infection and immunity 2000;68(2):485-91.
1999: Corinne Ploix; I Bergerot; A Durand; Cecil Czerkinsky; Jan Holmgren; Charles Thivolet
Oral administration of cholera toxin B-insulin conjugates protects NOD mice from autoimmune diabetes by inducing CD4+ regulatory T-cells.
Diabetes 1999;48(11):2150-6.
1999: Kristina Eriksson; Marianne Quiding-Järbrink; J Osek; Inger Nordström; M Hjulström; Jan Holmgren; Cecil Czerkinsky
Anatomic segmentation of the intestinal immune response in nonhuman primates: differential distribution of B cells after oral and rectal immunizations to sites defined by their source of vascularization.
Infection and immunity 1999;67(11):6210-2.
1999: Ursula Wiedermann; Beatrice Jahn-Schmid; Marianne Lindblad; Carola Rask; Jan Holmgren; Dietrich Kraft; Christof Ebner
Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy.
International immunology 1999;11(10):1717-24.
1999: Cecil Czerkinsky; F Anjuere; J R McGhee; Annie George Chandy; Jan Holmgren; M P Kieny; K Fujiyashi; J F Mestecky; V Pierrefite-Carle; Carola Rask; Jia-Bin Sun
Mucosal immunity and tolerance: relevance to vaccine development.
Immunological reviews 1999;170():197-222.
1999: Andrej Tarkowski; Jia-Bin Sun; Rikard Holmdahl; Jan Holmgren; Cecil Czerkinsky
Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine.
Arthritis and rheumatism 1999;42(8):1628-34.
1999: Jia-Bin Sun; Nathalie Mielcarek; M Lakew; J M Grzych; Andre Capron; Jan Holmgren; Cecil Czerkinsky
Intranasal administration of a Schistosoma mansoni glutathione S-transferase-cholera toxoid conjugate vaccine evokes antiparasitic and antipathological immunity in mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):1045-52.
1999: Ursula Wiedermann; Beatrice Jahn-Schmid; Marianne Lindblad; Carola Rask; Jan Holmgren; Dietrich Kraft; Christof Ebner
Suppressive versus stimulatory effects of allergen/cholera toxoid (CTB) conjugates depending on the nature of the allergen in a murine model of type I allergy.
International immunology 1999;11(7):1131-8.
1999: Anna Rudin; Gerdt C Riise; Jan Holmgren
Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit.
Infection and immunity 1999;67(6):2884-90.
1999: Eva-Liz Johansson; Anna Rudin; L Wassén; Jan Holmgren
Distribution of lymphocytes and adhesion molecules in human cervix and vagina.
Immunology 1999;96(2):272-7.
1999: Cecil Czerkinsky; Jia-Bin Sun; Jan Holmgren
Oral tolerance and anti-pathological vaccines.
Current topics in microbiology and immunology 1999;236():79-91.
1998: Kristina Eriksson; Marianne Quiding-Järbrink; J Osek; A Möller; S Björk; Jan Holmgren; Cecil Czerkinsky
Specific-antibody-secreting cells in the rectums and genital tracts of nonhuman primates following vaccination.
Infection and immunity 1998;66(12):5889-96.
1998: Charlotta Bergquist; Teresa Lagergård; Jan Holmgren
Antibody responses in serum and lung to intranasal immunization with Haemophilus influenzae type b polysaccharide conjugated to cholera toxin B subunit and tetanus toxoid.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1998;106(8):800-6.
1998: Anna Rudin; Eva-Liz Johansson; Charlotta Bergquist; Jan Holmgren
Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans.
Infection and immunity 1998;66(7):3390-6.
1998: Eva-Liz Johansson; Carola Rask; Margareta Fredriksson; Kristina Eriksson; Cecil Czerkinsky; Jan Holmgren
Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates.
Infection and immunity 1998;66(2):514-20.
1998: Marianne Jertborn; C Ahrén; Jan Holmgren; Ann-Mari Svennerholm
Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine.
Vaccine 1998;16(2-3):255-60.
1997: Charlotta Bergquist; Eva-Liz Johansson; Teresa Lagergård; Jan Holmgren; Anna Rudin
Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina.
Infection and immunity 1997;65(7):2676-84.
1997: M Villavedra; Hernan Carol; M Hjulström; Jan Holmgren; Cecil Czerkinsky
"PERFEXT": a direct method for quantitative assessment of cytokine production in vivo at the local level.
Research in immunology 1997;148(4):257-66.
1997: Malin Bäckström; V Shahabi; S Johansson; Susann Teneberg; Anders Kjellberg; Halina Miller-Podraza; Jan Holmgren; Michael Lebens
Structural basis for differential receptor binding of cholera and Escherichia coli heat-labile toxins: influence of heterologous amino acid substitutions in the cholera B-subunit.
Molecular microbiology 1997;24(3):489-97.
1997: Charlotta Bergquist; Teresa Lagergård; Jan Holmgren
Anticarrier immunity suppresses the antibody response to polysaccharide antigens after intranasal immunization with the polysaccharide-protein conjugate.
Infection and immunity 1997;65(5):1579-83.
1997: I Bergerot; Corinne Ploix; J Petersen; V Moulin; Carola Rask; Nicole Fabien; Marianne Lindblad; A Mayer; Cecil Czerkinsky; Jan Holmgren; Charles Thivolet
A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4610-4.
1997: Marianne Quiding-Järbrink; Inger Nordström; Gösta Granström; Anders Kilander; Marianne Jertborn; E C Butcher; A I Lazarovits; Jan Holmgren; Cecil Czerkinsky
Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses.
The Journal of clinical investigation 1997;99(6):1281-6.
1996: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
Intestinal and systemic immune responses in humans after oral immunization with a bivalent B subunit-O1/O139 whole cell cholera vaccine.
Vaccine 1996;14(15):1459-65.
1996: G Jonson; J Osek; Ann-Mari Svennerholm; Jan Holmgren
Immune mechanisms and protective antigens of Vibrio cholerae serogroup O139 as a basis for vaccine development.
Infection and immunity 1996;64(9):3778-85.
1996: Jia-Bin Sun; Carola Rask; T Olsson; Jan Holmgren; Cecil Czerkinsky
Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7196-201.
1996: M Lebens; V Shahabi; Malin Bäckström; T Houze; N Lindblad; Jan Holmgren
Synthesis of hybrid molecules between heat-labile enterotoxin and cholera toxin B subunits: potential for use in a broad-spectrum vaccine.
Infection and immunity 1996;64(6):2144-50.
1996: Jan Holmgren; P Brantzaeg; A Capron; M Francotte; M Kilian; J P Kraehenbuhl; T Lehner; R Seljelid
European Commission COST/STD Initiative. Report of the expert panel VI. Concerted efforts in the field of mucosal immunology.
Vaccine 1996;14(7):644-64.
1996: Cecil Czerkinsky; Jia-Bin Sun; M Lebens; B L Li; Carola Rask; Marianne Lindblad; Jan Holmgren
Cholera toxin B subunit as transmucosal carrier-delivery and immunomodulating system for induction of antiinfectious and antipathological immunity.
Annals of the New York Academy of Sciences 1996;778():185-93.
1996: F P van Loon; John D Clemens; Jyotsnamoy Chakraborty; Malla Rao; B A Kay; David A Sack; Mohammad Yunus; M Ali; Ann-Mari Svennerholm; Jan Holmgren
Field trial of inactivated oral cholera vaccines in Bangladesh: results from 5 years of follow-up.
Vaccine 1996;14(2):162-6.
1995: M Bckström; Jan Holmgren; F Schödel; M Lebens
Characterization of an internal permissive site in the cholera toxin B-subunit and insertion of epitopes from human immunodeficiency virus-1, hepatitis B virus and enterotoxigenic Escherichia coli.
Gene 1995;165(2):163-71.
1995: Kristina Eriksson; Anders Kilander; Lars Hagberg; Gunnar Norkrans; Jan Holmgren; Cecil Czerkinsky
Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals.
AIDS (London, England) 1995;9(7):695-700.
1995: Charlotta Bergquist; Teresa Lagergård; Marianne Lindblad; Jan Holmgren
Local and systemic antibody responses to dextran-cholera toxin B subunit conjugates.
Infection and immunity 1995;63(5):2021-5.
1995: Marianne Quiding-Järbrink; G Granström; Inger Nordström; Jan Holmgren; Cecil Czerkinsky
Induction of compartmentalized B-cell responses in human tonsils.
Infection and immunity 1995;63(3):853-7.
1995: Marianne Quiding-Järbrink; M Lakew; Inger Nordström; Jacques Banchereau; E Butcher; Jan Holmgren; Cecil Czerkinsky
Human circulating specific antibody-forming cells after systemic and mucosal immunizations: differential homing commitments and cell surface differentiation markers.
European journal of immunology 1995;25(2):322-7.
1995: U Wiedermann; Lars A Hanson; Jan Holmgren; Ulf I Dahlgren
Impaired mucosal immune response in vitamin A deficient rats immunized with oral cholera vaccine.
Advances in experimental medicine and biology 1995;371B():1629-31.
1995: Ann-Mari Svennerholm; Jan Holmgren
Oral vaccines against cholera and enterotoxigenic Escherichia coli diarrhea.
Advances in experimental medicine and biology 1995;371B():1623-8.
1995: A K Bromander; M Kjerrulf; Jan Holmgren; Nils Lycke
Cholera toxin enhances antigen presentation.
Advances in experimental medicine and biology 1995;371B():1501-6.
1995: M Lakew; Inger Nordström; M Quiding; Jan Holmgren; E Butcher; Cecil Czerkinsky
Phenotypic characterization of circulating antibody-secreting cells after mucosal and systemic immunizations in humans.
Advances in experimental medicine and biology 1995;371B():1451-3.
1995: M Quiding; M Lakew; G Granström; Inger Nordström; Jan Holmgren; Cecil Czerkinsky
Induction of specific antibody responses in the human nasopharyngeal mucosa.
Advances in experimental medicine and biology 1995;371B():1445-50.
1995: Kristina Eriksson; Anders Kilander; Lars Hagberg; Gunnar Norkrans; Jan Holmgren; Cecil Czerkinsky
Intestinal immune responsiveness in HIV-infected individuals.
Advances in experimental medicine and biology 1995;371B():1011-4.
1994: Y Furuta; Kristina Eriksson; Bo Svennerholm; Pam Fredman; Peter Horal; Stig Jeansson; A Vahlne; Jan Holmgren; Cecil Czerkinsky
Infection of vaginal and colonic epithelial cells by the human immunodeficiency virus type 1 is neutralized by antibodies raised against conserved epitopes in the envelope glycoprotein gp120.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12559-63.
1994: Malin Bäckström; M Lebens; F Schödel; Jan Holmgren
Insertion of a HIV-1-neutralizing epitope in a surface-exposed internal region of the cholera toxin B-subunit.
Gene 1994;149(2):211-7.
1994: Jia-Bin Sun; Jan Holmgren; Cecil Czerkinsky
Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10795-9.
1994: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
Immunological memory after immunization with oral cholera B subunit--whole-cell vaccine in Swedish volunteers.
Vaccine 1994;12(12):1078-82.
1994: G Jonson; M Lebens; Jan Holmgren
Cloning and sequencing of Vibrio cholerae mannose-sensitive haemagglutinin pilin gene: localization of mshA within a cluster of type 4 pilin genes.
Molecular microbiology 1994;13(1):109-18.
1994: J Osek; G Jonson; Ann-Mari Svennerholm; Jan Holmgren
Role of antibodies against biotype-specific Vibrio cholerae pili in protection against experimental classical and El Tor cholera.
Infection and immunity 1994;62(7):2901-7.
1994: M Lebens; Jan Holmgren
Structure and arrangement of the cholera toxin genes in Vibrio cholerae O139.
FEMS microbiology letters 1994;117(2):197-202.
1994: V Friman; M Quiding; Cecil Czerkinsky; Inger Nordström; L Larsson; D Ericson; J Björkander; K Theman; Anders Kilander; Jan Holmgren
Intestinal and circulating antibody-forming cells in IgA-deficient individuals after oral cholera vaccination.
Clinical and experimental immunology 1994;95(2):222-6.
1994: Jan Holmgren; Cecil Czerkinsky; Nils Lycke; Ann-Mari Svennerholm
Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant.
The American journal of tropical medicine and hygiene 1994;50(5 Suppl):42-54.
1994: Jan Holmgren
Receptors for cholera toxin and Escherichia coli heat-labile enterotoxin revisited.
Progress in brain research 1994;101():163-77.
1994: M Lebens; Jan Holmgren
Mucosal vaccines based on the use of cholera toxin B subunit as immunogen and antigen carrier.
Developments in biological standardization 1994;82():215-27.
1993: M Lebens; S Johansson; J Osek; Marianne Lindblad; Jan Holmgren
Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines.
Bio/technology (Nature Publishing Company) 1993;11(13):1574-8.
1993: U Wiedermann; Lars A Hanson; Jan Holmgren; H Kahu; Ulf I Dahlgren
Impaired mucosal antibody response to cholera toxin in vitamin A-deficient rats immunized with oral cholera vaccine.
Infection and immunity 1993;61(9):3952-7.
1993: Jan Holmgren; Nils Lycke; Cecil Czerkinsky
Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems.
Vaccine 1993;11(12):1179-84.
1993: Kristina Eriksson; Anders Kilander; Lars Hagberg; Gunnar Norkrans; Jan Holmgren; Cecil Czerkinsky
Intestinal antibody responses to oral vaccination in HIV-infected individuals.
AIDS (London, England) 1993;7(8):1087-91.
1993: D E Nilssen; V Friman; K Theman; J Björkander; Anders Kilander; Jan Holmgren; Lars A Hanson; Per Brandtzaeg
B-cell activation in duodenal mucosa after oral cholera vaccination in IgA deficient subjects with or without IgG subclass deficiency.
Scandinavian journal of immunology 1993;38(2):201-8.
1993: John Clemens; David A Sack; Malla Rao; Jyotsnamoy Chakraborty; B Kay; Firoz Ahmed; M R Khan; F P van Loon; Ann-Mari Svennerholm; Jan Holmgren
The design and analysis of cholera vaccine trials: recent lessons from Bangladesh.
International journal of epidemiology 1993;22(4):724-30.
1993: A K Bromander; M Kjerrulf; Jan Holmgren; Nils Lycke
Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells.
Scandinavian journal of immunology 1993;37(4):452-8.
1993: Cecil Czerkinsky; Ann-Mari Svennerholm; Jan Holmgren
Induction and assessment of immunity at enteromucosal surfaces in humans: implications for vaccine development.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993;16 Suppl 2():S106-16.
1993: Lars A Hanson; Esbjörn Telemo; U Wiedermann; A Dahlman; R Saalman; Staffan Ahlstedt; V Friman; Jan Holmgren; Cecil Czerkinsky; Ulf I Dahlgren
Sensitization and development of tolerance via the gut.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1993;4(3 Suppl):16-20.
1993: C Ahrén; Christine Wennerås; Jan Holmgren; Ann-Mari Svennerholm
Intestinal antibody response after oral immunization with a prototype cholera B subunit-colonization factor antigen enterotoxigenic Escherichia coli vaccine.
Vaccine 1993;11(9):929-34.
1993: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
Evaluation of different immunization schedules for oral cholera B subunit-whole cell vaccine in Swedish volunteers.
Vaccine 1993;11(10):1007-12.
1993: D E Nilssen; V Friman; K Theman; J Björkander; Anders Kilander; Jan Holmgren; Lars A Hanson; Per Brandtzaeg
Intestinal immunoglobulin production after oral cholera vaccination in patients with IgA deficiency with or without IgG subclass deficiency.
Immunodeficiency 1993;4(1-4):55-7.
1993: M Quiding; G Granström; Inger Nordström; B Ferrua; Jan Holmgren; Cecil Czerkinsky
High frequency of spontaneous interferon-gamma-producing cells in human tonsils: role of local accessory cells and soluble factors.
Clinical and experimental immunology 1993;91(1):157-63.
1992: J Osek; G Jonson; Ann-Mari Svennerholm; Jan Holmgren
Enzyme-linked immunosorbent assay for determination of antibodies to Vibrio cholerae toxin-coregulated pili.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1992;100(11):1027-32.
1992: J Osek; Ann-Mari Svennerholm; Jan Holmgren
Protection against Vibrio cholerae El Tor infection by specific antibodies against mannose-binding hemagglutinin pili.
Infection and immunity 1992;60(11):4961-4.
1992: G Jonson; Jan Holmgren; Ann-Mari Svennerholm
Analysis of expression of toxin-coregulated pili in classical and El Tor Vibrio cholerae O1 in vitro and in vivo.
Infection and immunity 1992;60(10):4278-84.
1992: Nils Lycke; T Tsuji; Jan Holmgren
The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity.
European journal of immunology 1992;22(9):2277-81.
1992: Kristina Eriksson; Inger Nordström; Peter Horal; Stig Jeansson; Bo Svennerholm; A Vahlne; Jan Holmgren; Cecil Czerkinsky
Amplified ELISPOT assay for the detection of HIV-specific antibody-secreting cells in subhuman primates.
Journal of immunological methods 1992;153(1-2):107-13.
1992: Jan Holmgren; Cecil Czerkinsky
Cholera as a model for research on mucosal immunity and development of oral vaccines.
Current opinion in immunology 1992;4(4):387-91.
1992: Jan Holmgren; Ann-Mari Svennerholm
Bacterial enteric infections and vaccine development.
Gastroenterology clinics of North America 1992;21(2):283-302.
1992: Jan Holmgren; Cecil Czerkinsky; Nils Lycke; Ann-Mari Svennerholm
Mucosal immunity: implications for vaccine development.
Immunobiology 1992;184(2-3):157-79.
1992: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
Safety and immunogenicity of an oral recombinant cholera B subunit-whole cell vaccine in Swedish volunteers.
Vaccine 1992;10(2):130-2.
1992: Jan Holmgren; Ann-Mari Svennerholm; Marianne Jertborn; John Clemens; David A Sack; R Salenstedt; H Wigzell
An oral B subunit: whole cell vaccine against cholera.
Vaccine 1992;10(13):911-4.
1992: F T Brezicka; S Olling; B Bergman; Håkan Berggren; C P Engström; S Hammarström; Jan Holmgren; S Larsson; L Lindholm
Coexpression of ganglioside antigen Fuc-GM1, neural-cell adhesion molecule, carcinoembryonic antigen, and carbohydrate tumor-associated antigen CA 50 in lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1992;13(5-6):308-15.
1991: F T Brezicka; Jan Holmgren; I Kalies; L Lindholm
Tumor-cell killing by MAbs against fucosyl GM1, a ganglioside antigen associated with small-cell lung carcinoma.
International journal of cancer. Journal international du cancer 1991;49(6):911-8.
1991: A Vahlne; Peter Horal; Kristina Eriksson; Stig Jeansson; Lars Rymo; K G Hedström; Cecil Czerkinsky; Jan Holmgren; Bo Svennerholm
Immunizations of monkeys with synthetic peptides disclose conserved areas on gp120 of human immunodeficiency virus type 1 associated with cross-neutralizing antibodies and T-cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10744-8.
1991: Jan Holmgren
Mucosal immunity and vaccination.
FEMS microbiology immunology 1991;4(1):1-9.
1991: G Jonson; Jan Holmgren; Ann-Mari Svennerholm
Identification of a mannose-binding pilus on Vibrio cholerae El Tor.
Microbial pathogenesis 1991;11(6):433-41.
1991: G Jonson; Jan Holmgren; Ann-Mari Svennerholm
Epitope differences in toxin-coregulated pili produced by classical and El Tor Vibrio cholerae O1.
Microbial pathogenesis 1991;11(3):179-88.
1991: F T Brezicka; S Olling; B Bergman; Håkan Berggren; C P Engström; Jan Holmgren; S Larsson; L Lindholm
Immunohistochemical detection of two small cell lung carcinoma-associated antigens defined by MAbs F12 and 123C3 in bronchoscopy biopsy tissues.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1991;99(9):797-802.
1991: Björn Löwenadler; M Lake; A Elmblad; Erik D. F. Holmgren; Jan Holmgren; A Karlström; Ann-Mari Svennerholm
A recombinant Escherichia coli heat-stable enterotoxin (STa) fusion protein eliciting anti-STa neutralizing antibodies.
FEMS microbiology letters 1991;66(3):271-7.
1991: M Quiding; Inger Nordström; Anders Kilander; G Andersson; Lars A Hanson; Jan Holmgren; Cecil Czerkinsky
Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memory.
The Journal of clinical investigation 1991;88(1):143-8.
1991: A Bromander; Jan Holmgren; Nils Lycke
Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):2908-14.
1991: Cecil Czerkinsky; Ann-Mari Svennerholm; M Quiding; Roland Jonsson; Jan Holmgren
Antibody-producing cells in peripheral blood and salivary glands after oral cholera vaccination of humans.
Infection and immunity 1991;59(3):996-1001.
1990: J Sanchez; S Johansson; Björn Löwenadler; Ann-Mari Svennerholm; Jan Holmgren
Recombinant cholera toxin B subunit and gene fusion proteins for oral vaccination.
Research in microbiology 1990;141(7-8):971-9.
1990: R S Dubey; Marianne Lindblad; Jan Holmgren
Purification of El Tor cholera enterotoxins and comparisons with classical toxin.
Journal of general microbiology 1990;136(9):1839-47.
1990: Ann-Mari Svennerholm; Christine Wennerås; Jan Holmgren; M M McConnell; B Rowe
Roles of different coli surface antigens of colonization factor antigen II in colonization by and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits.
Infection and immunity 1990;58(2):341-6.
1990: Jan Holmgren; Ann-Mari Svennerholm
New vaccines against bacterial enteric infections.
Scandinavian journal of infectious diseases. Supplementum 1990;70():149-56.
1990: Jan Holmgren; Ann-Mari Svennerholm
Development of oral vaccines against cholera and enterotoxinogenic Escherichia coli diarrhea.
Scandinavian journal of infectious diseases. Supplementum 1990;76():47-53.
1990: Christine Wennerås; Jan Holmgren; Ann-Mari Svennerholm
The binding of colonization factor antigens of enterotoxigenic Escherichia coli to intestinal cell membrane proteins.
FEMS microbiology letters 1990;54(1-3):107-12.
1989: Jan Holmgren; J Fryklund; H Larsson
Gamma-interferon-mediated down-regulation of electrolyte secretion by intestinal epithelial cells: a local immune mechanism?
Scandinavian journal of immunology 1989;30(4):499-503.
1989: G Jonson; Ann-Mari Svennerholm; Jan Holmgren
Vibrio cholerae expresses cell surface antigens during intestinal infection which are not expressed during in vitro culture.
Infection and immunity 1989;57(6):1809-15.
1989: Ann-Mari Svennerholm; Jan Holmgren; David A Sack
Development of oral vaccines against enterotoxinogenic Escherichia coli diarrhoea.
Vaccine 1989;7(3):196-8.
1989: Cecil Czerkinsky; M W Russell; Nils Lycke; Marianne Lindblad; Jan Holmgren
Oral administration of a streptococcal antigen coupled to cholera toxin B subunit evokes strong antibody responses in salivary glands and extramucosal tissues.
Infection and immunity 1989;57(4):1072-7.
1989: Nils Lycke; Jan Holmgren
Adoptive transfer of gut mucosal antitoxin memory by isolated B cells 1 year after oral immunization with cholera toxin.
Infection and immunity 1989;57(4):1137-41.
1989: Jan Holmgren; John Clemens; David A Sack; Ann-Mari Svennerholm
New cholera vaccines.
Vaccine 1989;7(2):94-6.
1989: F T Brezicka; S Olling; Ola Nilsson; J Bergh; Jan Holmgren; S Sörenson; F Yngvason; L Lindholm
Immunohistological detection of fucosyl-GM1 ganglioside in human lung cancer and normal tissues with monoclonal antibodies.
Cancer research 1989;49(5):1300-5.
1989: R I Glass; Ann-Mari Svennerholm; Barbara J Stoll; M R Khan; S Huda; M I Huq; Jan Holmgren
Effects of undernutrition on infection with Vibrio cholerae O1 and on response to oral cholera vaccine.
The Pediatric infectious disease journal 1989;8(2):105-9.
1989: Nils Lycke; A K Bromander; Jan Holmgren
Role of local IgA antitoxin-producing cells for intestinal protection against cholera toxin challenge.
International archives of allergy and applied immunology 1989;88(3):273-9.
1989: Nils Lycke; A K Bromander; Lena Ekman; U Karlsson; Jan Holmgren
Cellular basis of immunomodulation by cholera toxin in vitro with possible association to the adjuvant function in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(1):20-7.
1989: J Sanchez; Jan Holmgren
Recombinant system for overexpression of cholera toxin B subunit in Vibrio cholerae as a basis for vaccine development.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):481-5.
1988: L N Larson; C Johansson; L Lindholm; Jan Holmgren
Mouse monoclonal antibodies for experimental immunotherapy promotes killing of tumor cells.
International journal of cancer. Journal international du cancer 1988;42(6):877-82.
1988: J Sanchez; Ann-Mari Svennerholm; Jan Holmgren
Genetic fusion of a non-toxic heat-stable enterotoxin-related decapeptide antigen to cholera toxin B-subunit.
FEBS letters 1988;241(1-2):110-4.
1988: William B Greenough; R I Glass; Jan Holmgren; M R Khan; K M Hossain; I Huq
Receptor blocking, cholera, and Escherichia coli toxins.
The Journal of infectious diseases 1988;158(5):1147-8.
1988: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
Five-year immunologic memory in Swedish volunteers after oral cholera vaccination.
The Journal of infectious diseases 1988;157(2):374-7.
1988: Ann-Mari Svennerholm; Y L Vidal; Jan Holmgren; M M McConnell; B Rowe
Role of PCF8775 antigen and its coli surface subcomponents for colonization, disease, and protective immunogenicity of enterotoxigenic Escherichia coli in rabbits.
Infection and immunity 1988;56(2):523-8.
1988: B E Persson; E Ståhle; L Påhlman; B Glimelius; Jan Holmgren
CA-50 as a tumour marker for monitoring colorectal cancer: antigen rises in patients postoperatively precede clinical manifestations of recurrence.
European journal of cancer & clinical oncology 1988;24(2):241-6.
1988: Marianne Jertborn; Ann-Mari Svennerholm; Jan Holmgren
IgG and IgA subclass distribution of antitoxin antibody responses after oral cholera vaccination or cholera disease.
International archives of allergy and applied immunology 1988;85(3):358-63.
1988: Jan Holmgren; Ann-Mari Svennerholm; L Gothefors; Marianne Jertborn; Barbara J Stoll
Enterotoxigenic Escherichia coli diarrhea in an endemic area prepares the intestine for an anamnestic immunoglobulin A antitoxin response to oral cholera B subunit vaccination.
Infection and immunity 1988;56(1):230-3.
1988: Nils Lycke; Jan Holmgren
Mucosal immune response to cholera toxin--cellular basis of memory and adjuvant action.
Monographs in allergy 1988;24():274-81.
1988: B E Persson; E Ståhle; L Påhlman; B Glimelius; Ola Nilsson; L Lindholm; B Norrgård-Pedersen; Jan Holmgren
A clinical study of CA-50 as a tumour marker for monitoring of colorectal cancer.
Medical oncology and tumor pharmacotherapy 1988;5(3):165-71.
1987: Jan Holmgren; Ann-Mari Svennerholm; John Clemens; David A Sack; Robert E Black; Myron M Levine
An oral B subunit-whole cell vaccine against cholera: from concept to successful field trial.
Advances in experimental medicine and biology 1987;216B():1649-60.
1986: Nils Lycke; Ann-Mari Svennerholm; Jan Holmgren
Strong biotype and serotype cross-protective antibacterial and antitoxic immunity in rabbits after cholera infection.
Microbial pathogenesis 1986;1(4):361-71.
1986: John D Clemens; M Jertborn; David A Sack; Bonita Stanton; Jan Holmgren; M R Khan; S Huda
Effect of neutralization of gastric acid on immune responses to an oral B subunit, killed whole-cell cholera vaccine.
The Journal of infectious diseases 1986;154(1):175-8.
1986: Barbara J Stoll; Ann-Mari Svennerholm; L Gothefors; D Barua; S Huda; Jan Holmgren
Local and systemic antibody responses to naturally acquired enterotoxigenic Escherichia coli diarrhea in an endemic area.
The Journal of infectious diseases 1986;153(3):527-34.
1986: Ola Nilsson; F T Brezicka; Jan Holmgren; S Sörenson; L Svennerholm; F Yngvason; L Lindholm
Detection of a ganglioside antigen associated with small cell lung carcinomas using monoclonal antibodies directed against fucosyl-GM1.
Cancer research 1986;46(3):1403-7.
1985: R I Glass; Jan Holmgren; C E Haley; M R Khan; Ann-Mari Svennerholm; Barbara J Stoll; K M Belayet Hossain; Robert E Black; Muhammad B. Yunus; D Barua
Predisposition for cholera of individuals with O blood group. Possible evolutionary significance.
American journal of epidemiology 1985;121(6):791-6.
1985: R I Glass; Ann-Mari Svennerholm; M R Khan; S Huda; M I Huq; Jan Holmgren
Seroepidemiological studies of El Tor cholera in Bangladesh: association of serum antibody levels with protection.
The Journal of infectious diseases 1985;151(2):236-42.
1984: Ann-Mari Svennerholm; Marianne Jertborn; L Gothefors; A M Karim; David A Sack; Jan Holmgren
Mucosal antitoxic and antibacterial immunity after cholera disease and after immunization with a combined B subunit-whole cell vaccine.
The Journal of infectious diseases 1984;149(6):884-93.
1984: R I Glass; Jan Holmgren; M R Khan; K M Hossain; M I Huq; William B Greenough
A randomized, controlled trial of the toxin-blocking effects of B subunit in family members of patients with cholera.
The Journal of infectious diseases 1984;149(4):495-500.
1983: R I Glass; Ann-Mari Svennerholm; Barbara J Stoll; M R Khan; K M Hossain; M I Huq; Jan Holmgren
Protection against cholera in breast-fed children by antibodies in breast milk.
The New England journal of medicine 1983;308(23):1389-92.
1983: L Lindholm; Jan Holmgren; M Wikström; U Karlsson; K Andersson; Nils Lycke
Monoclonal antibodies to cholera toxin with special reference to cross-reactions with Escherichia coli heat-labile enterotoxin.
Infection and immunity 1983;40(2):570-6.
1983: Ann-Mari Svennerholm; Marianne Jertborn; L Gothefors; A Karim; David A Sack; Jan Holmgren
Current status of an oral B subunit whole cell cholera vaccine.
Developments in biological standardization 1983;53():73-9.
1981: William B Greenough; Barbara J Stoll; Jan Holmgren; L Svennerholm; P Fredman; P K Bardhan; I Huq
Toxin absorption in cholera.
Lancet 1981;2(8239):208.
1980: Barbara J Stoll; Jan Holmgren; P K Bardhan; I Huq; William B Greenough; P Fredman; L Svennerholm
Binding of intraluminal toxin in cholera: trial of GM1 ganglioside charcoal.
Lancet 1980;2(8200):888-91.
1971: Jan Holmgren; Ivar Lönnroth; O Ouchterlony
Immunochemical Studies of Two Cholera Toxin-Containing Standard Culture Filtrate Preparations of Vibrio cholerae.
Infection and immunity 1971;3(6):747-55.