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Uffe Holmskov

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Chemicals & Drugs

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Helle Wulf-Johansson; Qihua Tan; Mikael Thinggaard; Kaare Christensen; Uffe Holmskov; Sofie Lock Johansson; Anders Schlosser; Grith Lykke Sorensen
Circulating surfactant protein D is associated to mortality in elderly women: a twin study.
Dorte Holm; Dorte Rosenbek Fink; Jesper Bonnet Moeller; Ole Nielsen; Anders Schlosser; Maria Abildgaard Steffensen; Uffe Holmskov
Characterization of a novel human scavenger receptor cysteine-rich molecule SCART1 expressed by lymphocytes.
Jens Madsen; Jan Mollenhauer; Ole Nielsen; Grith Lykke Sorensen; Lars Thim; Ida Tornøe; Claus Fenger; Uffe Holmskov
A Variant Form of the Human Deleted in Malignant Brain Tumor 1 (DMBT1) Gene Shows Increased Expression in Inflammatory Bowel Diseases and Interacts with Dimeric Trefoil Factor 3 (TFF3).

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2013: Helle Wulf-Johansson; Qihua Tan; Mikael Thinggaard; Kaare Christensen; Uffe Holmskov; Sofie Lock Johansson; Anders Schlosser; Grith Lykke Sorensen
Circulating surfactant protein D is associated to mortality in elderly women: a twin study.
Immunobiology 2013;218(5):712-7.
2013: Dorte Holm; Dorte Rosenbek Fink; Jesper Bonnet Moeller; Ole Nielsen; Anders Schlosser; Maria Abildgaard Steffensen; Uffe Holmskov
Characterization of a novel human scavenger receptor cysteine-rich molecule SCART1 expressed by lymphocytes.
Immunobiology 2013;218(3):408-17.
2013: Jens Madsen; Jan Mollenhauer; Ole Nielsen; Grith Lykke Sorensen; Lars Thim; Ida Tornøe; Claus Fenger; Uffe Holmskov
A Variant Form of the Human Deleted in Malignant Brain Tumor 1 (DMBT1) Gene Shows Increased Expression in Inflammatory Bowel Diseases and Interacts with Dimeric Trefoil Factor 3 (TFF3).
PloS one 2013;8(5):e64441.
2012: Nina Vitashenkova; Lars Vitved; Anthony Willis; Søren Hansen; Alexandra D Kharazova; Rikke Leth-Larsen; Kit Peiter Lund; Jesper Bonnet Moeller; Anders Schlosser; Karsten Skjødt; Grith Lykke Sorensen; Ida Tornøe; Uffe Holmskov
Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family.
The Journal of biological chemistry 2012;287(51):42846-55.
2012: Jesper Bonnet Moeller; Søren K Moestrup; Jan Mollenhauer; Maria E Nielsen; Marianne J Nielsen; Ole Nielsen; Martin P Reichhardt; Anders Schlosser; Grith L Sorensen; Ida Tornøe; Jørn Grønlund; Ole N Jensen; Jan S Jørgensen; Uffe Holmskov
CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(5):2399-409.
2012: Lana Selman; Karsten Skjodt; A Waters; P L Beales; J Brandt; M L Henriksen; Uffe Holmskov; T J D Jørgensen; Claus Nielsen; Y Palarasah; Soren Hansen
An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1).
Journal of immunological methods 2012;375(1-2):182-8.
2012: Youssif M Ali; Peter W Andrew; Thomas Dudler; Yuichi Endo; Teizo Fujita; Umakhanth V Girija; Kashif S Haleem; Soren Hansen; Uffe Holmskov; Aras Kadioglu; Nicholas J Lynch; Gregory L Stahl; Cordula M Stover; Kazue Takahashi; Russell Wallis; Wilhelm J Schwaeble
The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.
PLoS pathogens 2012;8(7):e1002793.
2012: Jacob V Stidsen; Peter Bie; Pernille B L Hansen; Samuel Hawgood; Uffe Holmskov; Karin Kejling; Reza Khorooshi; Katrine L Kirketerp-Møller; Susanne Mandrup; Claus Henrik Nielsen; Ole Nielsen; Trevor Owens; Martin K U Rahbek; Grith L Sørensen
Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia.
PloS one 2012;7(4):e35066.
2011: Vanesa Gabriela Martínez; Søren Kragh Moestrup; Jan Mollenhauer; Uffe Holmskov; Francisco Lozano
The conserved scavenger receptor cysteine-rich superfamily in therapy and diagnosis.
Pharmacological reviews 2011;63(4):967-1000.
2011: A F Christensen; S V Hoegh; Uffe Holmskov; Kim Hørslev-Petersen; Tine Lottenburger; Grith L Sørensen; Ida Tornoe; Peter Junker
Circadian rhythm and the influence of physical activity on circulating surfactant protein D in early and long-standing rheumatoid arthritis.
Rheumatology international 2011;31(12):1617-23.
2011: Annelyse Duvoix; Elena Miranda; Juan Perez; Grith L Sorensen; Uffe Holmskov; Bruce C Trapnell; Jens Madsen; Howard W Clark; Lisa D Edwards; Bruce E Miller; Ruth M Tal-Singer; David A Lomas
Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD.
COPD 2011;8(2):79-95.
2011: Cristina Miró-Julià; Sandra Roselló; Vanesa G Martínez; Dorte R Fink; Cristina Escoda-Ferran; Olga Padilla; Citlali Vázquez-Echeverría; Paula Espinal-Marin; Cristina Pujades; Angeles García-Pardo; Jordi Vila; Carles Serra-Pagès; Uffe Holmskov; José Yélamos; Francisco Lozano
Molecular and functional characterization of mouse S5D-SRCRB: a new group B member of the scavenger receptor cysteine-rich superfamily.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(4):2344-54.
2011: Pernille Lund Hansen; Stephanie Blaich; Caroline End; Steffen Schmidt; Jesper B Moeller; Uffe Holmskov; Jan Mollenhauer
The pattern recognition molecule deleted in malignant brain tumors 1 (DMBT1) and synthetic mimics inhibit liposomal nucleic acid delivery.
Chemical communications (Cambridge, England) 2011;47(1):188-90.
2011: Theresa Thomsen; Anders Schlosser; Uffe Holmskov; Grith L Sorensen
Ficolins and FIBCD1: soluble and membrane bound pattern recognition molecules with acetyl group selectivity.
Molecular immunology 2011;48(4):369-81.
2010: Karen Duus; Nicole M Thielens; Monique Lacroix; Pascale Tacnet; Philippe Frachet; Uffe Holmskov; Gunnar Houen
CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.
The FEBS journal 2010;277(23):4956-64.
2010: Soren Hansen; Lana Selman; Nades Palaniyar; Karel Ziegler; Jette Brandt; Anette Kliem; Maiken Jonasson; Mikkel-Ole Skjoedt; Ole Nielsen; Kevan Hartshorn; Thomas J D Jørgensen; Karsten Skjødt; Uffe Holmskov
Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(10):6096-104.
2010: Thomas Krogh-Meibom; Klaus L Ingvartsen; Ida Tornoe; Nades Palaniyar; Anthony C Willis; Uffe Holmskov
A simple two-step purification procedure for the iC3b binding collectin conglutinin.
Journal of immunological methods 2010;362(1-2):204-8.
2010: Kevan L Hartshorn; Mitchell R White; Michael Rynkiewicz; Grith Sorensen; Uffe Holmskov; James Head; Erika C Crouch
Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.
American journal of physiology. Lung cellular and molecular physiology 2010;299(3):L384-92.
2010: Kevan L Hartshorn; Mitchell R White; Kelly Smith; Glorian Sorensen; Y Kuroki; Uffe Holmskov; J Head; Erika C Crouch
Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity.
Scandinavian journal of immunology 2010;72(1):22-30.
2010: Hanne Vebert Olesen; Uffe Holmskov; Peter Oluf Schiøtz; Grith Lykke Sørensen
Serum-surfactant SP-D correlates inversely to lung function in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2010;9(4):257-62.
2010: Jens Madsen; Jan Mollenhauer; Uffe Holmskov
Review: Gp-340/DMBT1 in mucosal innate immunity.
Innate immunity 2010;16(3):160-7.
2010: Dorte Rosenbek Fink; Dorte Holm; Anders Schlosser; Ole Nielsen; Markus Latta; Francisco Lozano; Uffe Holmskov
Elevated numbers of SCART1+ gammadelta T cells in skin inflammation and inflammatory bowel disease.
Molecular immunology 2010;47(9):1710-8.
2010: Silje Vermedal Hoegh; Grith Lykke Sorensen; Ida Tornoe; Tine Lottenburger; Henriette Ytting; Hans Jørgen Nielsen; Peter Junker; Uffe Holmskov
Long-term stability and circadian variation in circulating levels of surfactant protein D.
Immunobiology 2010;215(4):314-20.
2010: Theresa Thomsen; Jesper Bonnet Moeller; Anders Schlosser; Grith L Sorensen; Søren K Moestrup; Nades Palaniyar; Russell Wallis; Jan Mollenhauer; Uffe Holmskov
The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition.
The Journal of biological chemistry 2010;285(2):1229-38.
2010: Anne Friesgaard Christensen; Grith Lykke Sørensen; Kim Hørslev-Petersen; Uffe Holmskov; Hanne Merete Lindegaard; Kirsten Junker; Merete Lund Hetland; Kristian Stengaard-Pedersen; Søren Jacobsen; Tine Lottenburger; Torkell Ellingsen; Lis Smedegaard Andersen; Ib Hansen; Henrik Skjødt; Jens Kristian Pedersen; Ulrik Birk Lauridsen; Anders Svendsen; Ulrik Tarp; Jan Pødenphant; Aage Vestergaard; Anne Grethe Jurik; Mikkel Østergaard; Peter Junker
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.
Arthritis research & therapy 2010;12(2):R39.
2010: Kevan L Hartshorn; Mitchell R White; Tesfaldet Tecle; Grith Sorensen; Uffe Holmskov; Erika C Crouch
Viral aggregating and opsonizing activity in collectin trimers.
American journal of physiology. Lung cellular and molecular physiology 2010;298(1):L79-88.
2009: Silje Vermedal Hoegh; Anne Voss; Grith L Sorensen; Anette Høj; Christian Bendixen; Peter Junker; Uffe Holmskov
Circulating surfactant protein D is decreased in systemic lupus erythematosus.
The Journal of rheumatology 2009;36(11):2449-53.
2009: Anders Schlosser; Theresa Thomsen; Jesper Bonnet Moeller; Ole Nielsen; Ida Tornøe; Jan Mollenhauer; Søren K Moestrup; Uffe Holmskov
Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3800-9.
2009: Grith L Sorensen; Silje V Hoegh; Rikke Leth-Larsen; Theresa H Thomsen; C Floridon; Kelly Smith; Karin Kejling; Ida Tornoe; Erika C Crouch; Uffe Holmskov
Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction.
Molecular immunology 2009;46(15):3060-9.
2009: Y P Wu; Z H Liu; R Wei; S D Pan; N Y Mao; B Chen; J J Han; F S Zhang; Uffe Holmskov; Zuo-Li Xia; P G de Groot; K B M Reid; W B Xu; Grith L Sorensen
Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
Scandinavian journal of immunology 2009;69(6):508-15.
2009: Dorte Holm; Dorte Rosenbek Fink; Jørn Grønlund; Søren Hansen; Uffe Holmskov
Cloning and characterization of SCART1, a novel scavenger receptor cysteine-rich type I transmembrane molecule.
Molecular immunology 2009;46(8-9):1663-72.
2009: Christian Mölleken; Barbara Sitek; Corinna Henkel; Gereon Poschmann; Bence Sipos; Sebastian Wiese; Bettina Warscheid; Christoph Broelsch; Markus Reiser; Scott L Friedman; Ida Tornøe; Anders Schlosser; Günter Klöppel; Wolff Schmiegel; Helmut E Meyer; Uffe Holmskov; Kai Stühler
Detection of novel biomarkers of liver cirrhosis by proteomic analysis.
Hepatology (Baltimore, Md.) 2009;49(4):1257-66.
2009: Caroline End; Floris J Bikker; Marcus Renner; Gaby Bergmann; Stefan Lyer; Stephanie Blaich; Melanie Hudler; Burkhard Helmke; Nikolaus Gassler; Frank Autschbach; Antoon J M Ligtenberg; Axel Benner; Uffe Holmskov; Peter Schirmacher; Arie V Nieuw Amerongen; Philip Rosenstiel; Christian Sina; Andre Franke; Mathias Hafner; Petra Kioschis; Stefan Schreiber; Annemarie Poustka; Jan Mollenhauer
DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands.
European journal of immunology 2009;39(3):833-42.
2009: Mary Y K Lee; Grith L Sørensen; Uffe Holmskov; Paul M Vanhoutte
The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging.
Molecular immunology 2009;46(6):1050-7.
2008: Lana Selman; Karsten Skjodt; Ole Nielsen; C Floridon; Uffe Holmskov; Soren Hansen
Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues.
Molecular immunology 2008;45(11):3278-88.
2008: Tesfaldet Tecle; Mitchell R White; Grith L Sorensen; Donald Gantz; Nilgun Kacak; Uffe Holmskov; Kelly Smith; Erika C Crouch; Kevan L Hartshorn
Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus.
The Biochemical journal 2008;412(2):323-9.
2008: Asbjørg Stray-Pedersen; Ashild Vege; Asbjorg Stray-Pedersen; Uffe Holmskov; Torleiv O Rognum
Post-neonatal drop in alveolar SP-A expression: biological significance for increased vulnerability to SIDS?
Pediatric pulmonology 2008;43(2):160-8.
2008: Soren Hansen; Vivi Schmidt; Maria Abildgaard Steffensen; Pia Hoennerup Jensen; Morten F Gjerstorff; Steffen Thiel; Uffe Holmskov
An enzyme-linked immunosorbent assay (ELISA) for quantification of mouse surfactant protein D (SP-D).
Journal of immunological methods 2008;330(1-2):75-85.
2008: S V Hoegh; Hanne Merete Lindegaard; Grith L Sorensen; Anette Høj; Christian Bendixen; Peter Junker; Uffe Holmskov
Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Scandinavian journal of immunology 2008;67(1):71-6.
2007: Marcus Renner; Gaby Bergmann; Inge Krebs; Caroline End; Stefan Lyer; Frank Hilberg; Burkhard Helmke; Nikolaus Gassler; Frank Autschbach; Floris J Bikker; Olga Strobel-Freidekind; Sabine Gronert-Sum; Axel Benner; Stephanie Blaich; Rainer Wittig; Melanie Hudler; Antoon J M Ligtenberg; Jens Madsen; Uffe Holmskov; Vito Annese; Anna Latiano; Peter Schirmacher; Arie V Nieuw Amerongen; Mauro D'Amato; Petra Kioschis; Mathias Hafner; Annemarie Poustka; Jan Mollenhauer
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.
Gastroenterology 2007;133(5):1499-509.
2007: Esben Thormann; Jakob K Dreyer; Adam Cohen Simonsen; Per Lyngs Hansen; Søren Hansen; Uffe Holmskov; Ole G Mouritsen
Dynamic strength of the interaction between lung surfactant protein D (SP-D) and saccharide ligands.
Biochemistry 2007;46(43):12231-7.
2007: X M Zhao; Y P Wu; R Wei; H X Cai; Ida Tornoe; J J Han; Y Wang; P G de Groot; Uffe Holmskov; Zuo-Li Xia; Grith L Sorensen
Plasma surfactant protein D levels and the relation to body mass index in a chinese population.
Scandinavian journal of immunology 2007;66(1):71-6.
2007: Mads Nybo; Kjeld Andersen; Grith L Sorensen; Annette Lolk; Per Kragh-Sorensen; Uffe Holmskov
Serum surfactant protein D is correlated to development of dementia and augmented mortality.
Clinical immunology (Orlando, Fla.) 2007;123(3):333-7.
2007: Jens Madsen; Ole Nielsen; Ida Tornøe; Lars Thim; Uffe Holmskov
Tissue localization of human trefoil factors 1, 2, and 3.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(5):505-13.
2007: Grith Lykke Sorensen; Steffen Husby; Uffe Holmskov
Surfactant protein A and surfactant protein D variation in pulmonary disease.
Immunobiology 2007;212(4-5):381-416.
2007: Rikke Leth-Larsen; Fei Zhong; Vincent T K Chow; Uffe Holmskov; Jinhua Lu
The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages.
Immunobiology 2007;212(3):201-11.
2007: Kevan L Hartshorn; Mitchell R White; Tesfaldet Tecle; Ida Tornoe; Grith L Sorensen; Erika C Crouch; Uffe Holmskov
Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D.
Respiratory research 2007;8():9.
2007: Grith L Sorensen; Inge Petersen; Steffen Thiel; Mogens Fenger; Kaare Christensen; Kirsten Ohm Kyvik; Thorkild I A Sørensen; Uffe Holmskov; Jens Christian Jensenius
Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity.
Genetic epidemiology 2007;31(1):31-41.
2007: Soren Hansen; Bernice Lo; Kathy Evans; Pavlos Neophytou; Uffe Holmskov; Jo Rae Wright
Surfactant protein D augments bacterial association but attenuates major histocompatibility complex class II presentation of bacterial antigens.
American journal of respiratory cell and molecular biology 2007;36(1):94-102.
2006: Grith L Sorensen; Jacob v B Hjelmborg; Rikke Leth-Larsen; V Schmidt; Mogens Fenger; Francis Poulain; Samuel Hawgood; Thorkild I A Sørensen; Kirsten Ohm Kyvik; Uffe Holmskov
Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice.
Scandinavian journal of immunology 2006;64(6):633-8.
2006: Anders Schlosser; T Thomsen; J Michael Shipley; Patrick W Hein; F Brasch; Ida Tornøe; Ole Nielsen; Karsten Skjødt; Nades Palaniyar; W Steinhilber; Francis X McCormack; Uffe Holmskov
Microfibril-associated protein 4 binds to surfactant protein A (SP-A) and colocalizes with SP-A in the extracellular matrix of the lung.
Scandinavian journal of immunology 2006;64(2):104-16.
2006: Erika C Crouch; Kelly Smith; Barbara McDonald; David Briner; Bruce Linders; Joseph McDonald; Uffe Holmskov; James Head; Kevan L Hartshorn
Species differences in the carbohydrate binding preferences of surfactant protein D.
American journal of respiratory cell and molecular biology 2006;35(1):84-94.
2006: Kevan L Hartshorn; Mitchell R White; Tesfaldet Tecle; Uffe Holmskov; Erika C Crouch
Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6962-72.
2006: Marianne Dahl; Uffe Holmskov; Steffen Husby; Pekka Olavi Juvonen
Surfactant protein D levels in umbilical cord blood and capillary blood of premature infants. The influence of perinatal factors.
Pediatric research 2006;59(6):806-10.
2006: Grith L Sorensen; Jens Madsen; Karin Kejling; Ida Tornoe; Ole Nielsen; Paul Townsend; Francis Poulain; Claus Henrik Nielsen; Kenneth B M Reid; Samuel Hawgood; Erling Falk; Uffe Holmskov
Surfactant protein D is proatherogenic in mice.
American journal of physiology. Heart and circulatory physiology 2006;290(6):H2286-94.
2006: Grith L Sørensen; Jacob v B Hjelmborg; Kirsten Ohm Kyvik; Mogens Fenger; Anette Høj; Christian Bendixen; Thorkild I A Sørensen; Uffe Holmskov
Genetic and environmental influences of surfactant protein D serum levels.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L1010-7.
2006: Helle R Juul-Madsen; Thomas Krogh-Meibom; Mark Henryon; Nades Palaniyar; Peter M H Heegaard; Stig Purup; Anthony C Willis; Ida Tornøe; Klaus L Ingvartsen; Søren Hansen; Uffe Holmskov
Identification and characterization of porcine mannan-binding lectin A (pMBL-A), and determination of serum concentration heritability.
Immunogenetics 2006;58(2-3):129-37.
2006: Thomas Hohwy; Kristian Otkjaer; Jens Madsen; Gritt Søerensen; Ole Nielsen; Christian Vestergaard; Torben Steiniche; Uffe Holmskov; Hans Lomholt
Surfactant protein D in atopic dermatitis and psoriasis.
Experimental dermatology 2006;15(3):168-74.
2006: Kevan L Hartshorn; Antoon J M Ligtenberg; Mitchell R White; Martin van Eijk; Max Hartshorn; Lily Pemberton; Uffe Holmskov; Erika Crouch
Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation.
The Biochemical journal 2006;393(Pt 2):545-53.
2005: Joseph Meschi; Erika C Crouch; Paul Skolnik; Khabirah Yahya; Uffe Holmskov; Rikke Leth-Larsen; Ida Tornoe; Tesfaldet Tecle; Mitchell R White; Kevan L Hartshorn
Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.
The Journal of general virology 2005;86(Pt 11):3097-107.
2005: Marianne Dahl; Pekka Olavi Juvonen; Uffe Holmskov; Steffen Husby
Surfactant protein D in newborn infants: factors influencing surfactant protein D levels in umbilical cord blood and capillary blood.
Pediatric research 2005;58(5):908-12.
2005: Mitchell R White; Erika Crouch; Jenny Vesona; Paul J Tacken; Joseph J Batenburg; Rikke Leth-Larsen; Uffe Holmskov; Kevan L Hartshorn
Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus.
American journal of physiology. Lung cellular and molecular physiology 2005;289(4):L606-16.
2005: Charlotte M Soerensen; Uffe Holmskov; Bent Aalbaek; Mette Boye; Peter M H Heegaard; Ole Lerberg Nielsen
Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue.
Immunology 2005;115(4):526-35.
2005: Weiqun Kang; Ole Nielsen; Claus Fenger; Graham Leslie; Uffe Holmskov; Kenneth B M Reid
Induction of DMBT1 expression by reduced ERK activity during a gastric mucosa differentiation-like process and its association with human gastric cancer.
Carcinogenesis 2005;26(6):1129-37.
2005: Mitchell R White; Erika Crouch; Martin van Eijk; Max Hartshorn; Lily Pemberton; Ida Tornoe; Uffe Holmskov; Kevan L Hartshorn
Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor.
American journal of physiology. Lung cellular and molecular physiology 2005;288(5):L831-40.
2005: Erika Crouch; Yizheng Tu; David Briner; Barbara McDonald; Kelly Smith; Uffe Holmskov; Kevan L Hartshorn
Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus.
The Journal of biological chemistry 2005;280(17):17046-56.
2005: Rikke Leth-Larsen; Peter Garred; Henriette Jensenius; Joseph Meschi; Kevan L Hartshorn; Jens Madsen; Ida Tornoe; Hans O Madsen; Grith L Sørensen; Erika Crouch; Uffe Holmskov
A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1532-8.
2005: C M Soerensen; Ole Lerberg Nielsen; A Willis; Peter M H Heegaard; Uffe Holmskov
Purification, characterization and immunolocalization of porcine surfactant protein D.
Immunology 2005;114(1):72-82.
2004: Thomas Krogh-Meibom; Uffe Holmskov; Peter Løvendahl; Klaus L Ingvartsen
A time-resolved immunofluorometric assay for quantification of collectin-43.
Journal of immunological methods 2004;295(1-2):161-7.
2004: Morten F Gjerstorff; Soren Hansen; B Jensen; B Dueholm; P Horn; Christian Bendixen; Uffe Holmskov
The genes encoding bovine SP-A, SP-D, MBL-A, conglutinin, CL-43 and CL-46 form a distinct collectin locus on Bos taurus chromosome 28 (BTA28) at position q.1.8-1.9.
Animal genetics 2004;35(4):333-7.
2004: Morten F Gjerstorff; Jens Madsen; Christian Bendixen; Uffe Holmskov; Soren Hansen
Genomic and molecular characterization of bovine surfactant protein D (SP-D).
Molecular immunology 2004;41(4):369-76.
2004: Charlotte H Jensen; Eva Irene Jauho; Eric Santoni-Rugiu; Uffe Holmskov; Børge Teisner; Niels Tygstrup; Hanne Cathrine Bisgaard
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1.
The American journal of pathology 2004;164(4):1347-59.
2004: Thomas Krogh-Meibom; Uffe Holmskov; Peter Løvendahl; NI Nielsen; Klaus L Ingvartsen
A time-resolved immunofluorometric assay for quantification of the bovine collectin conglutinin.
Journal of immunological methods 2004;286(1-2):87-96.
2004: Claus Gravholt; Rikke Leth-Larsen; Anna Lis Lauridsen; Steffen Thiel; Troels Krarup Hansen; Uffe Holmskov; Rune Weis Naeraa; Jens Sandahl Christiansen
The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2004;150(3):355-62.
2004: Rikke Leth-Larsen; C Floridon; Ole Nielsen; Uffe Holmskov
Surfactant protein D in the female genital tract.
Molecular human reproduction 2004;10(3):149-54.
2004: Jan Mollenhauer; Burkhard Helmke; Daniel Medina; Gaby Bergmann; Nikolaus Gassler; Hanna Müller; Stefan Lyer; Laura Diedrichs; Marcus Renner; Rainer Wittig; Stephanie Blaich; Ute Hamann; Jens Madsen; Uffe Holmskov; Floris J Bikker; Antoon J M Ligtenberg; Anette Carlén; Jan Olsson; Herwart F Otto; Bert O'Malley; Annemarie Poustka
Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.
Genes, chromosomes & cancer 2004;39(3):185-94.
2004: Morten F Gjerstorff; B Dueholm; Christian Bendixen; Uffe Holmskov; Soren Hansen
Assignment of the surfactant protein A gene (SFTPA) to bovine chromosome 28q1.8-->q1.9 by radiation hybrid mapping.
Cytogenetic and genome research 2004;106(1):142.
2004: Maria-Rosa Sarrias; Jørn Grønlund; Olga Padilla; Jens Madsen; Uffe Holmskov; Francisco Lozano
The Scavenger Receptor Cysteine-Rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system.
Critical reviews in immunology 2004;24(1):1-37.
2003: Kevan L Hartshorn; Mitchell R White; Tirsit Mogues; Toon Ligtenberg; Erika Crouch; Uffe Holmskov
Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1066-76.
2003: Jens Madsen; Ida Tornoe; Ole Nielsen; Claus Koch; Wolfram Steinhilber; Uffe Holmskov
Expression and localization of lung surfactant protein A in human tissues.
American journal of respiratory cell and molecular biology 2003;29(5):591-7.
2003: Jens Madsen; Ida Tornøe; Ole Nielsen; Mette Lausen; Inge Krebs; Jan Mollenhauer; Gaby Kollender; Annemarie Poustka; Karsten Skjødt; Uffe Holmskov
CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D.
European journal of immunology 2003;33(8):2327-36.
2003: Rikke Leth-Larsen; Claudia Nordenbaek; Ida Tornoe; Vivi Moeller; Anders Schlosser; Claus Koch; Børge Teisner; Peter Junker; Uffe Holmskov
Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia small star, filled.
Clinical immunology (Orlando, Fla.) 2003;108(1):29-37.
2003: Jan Mollenhauer; Martin Deichmann; Burkhard Helmke; Hanna Müller; Gaby Kollender; Uffe Holmskov; Toon Ligtenberg; Inge Krebs; Stefan Wiemann; Ursula Bantel-Schaal; Jens Madsen; Floris J Bikker; Sabine M Klauck; Herwart F Otto; Gerhard Moldenhauer; Annemarie Poustka
Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer.
International journal of cancer. Journal international du cancer 2003;105(2):149-57.
2003: Alex Lund Laursen; Niels Obel; Uffe Holmskov; Jens C Jensenius; El Moukhtar Aliouat; Paul L Andersen
Activation of the respiratory burst by Pneumocystis carinii. Efficiency of different antibody isotypes, complement, lung surfactant protein D, and mannan-binding lectin.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(3):405-15.
2003: Soren Hansen; Dorte Holm; Vivi Moeller; Lars Vitved; Christian Bendixen; Karsten Skjoedt; Uffe Holmskov
Genomic and molecular characterization of CL-43 and its proximal promoter.
Biochimica et biophysica acta 2003;1625(1):1-10.
2003: Hans Jürgen Hoffmann; Martin Iversen; Ivan Brandslund; Torben Sigsgaard; Øyvind Omland; Claus Oxvig; Uffe Holmskov; Leif Bjermer; Jens Christian Jensenius; Ronald Dahl
Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings.
Annals of agricultural and environmental medicine : AAEM 2003;10(1):53-60.
2003: Uffe Holmskov; Steffen Thiel; Jens C Jensenius
Collections and ficolins: humoral lectins of the innate immune defense.
Annual review of immunology 2003;21():547-78.
2002: Weiqun Kang; Ole Nielsen; C Fenger; J Madsen; S Hansen; Ida Tornoe; Paul Eggleton; Kenneth B M Reid; Uffe Holmskov
The scavenger receptor, cysteine-rich domain-containing molecule gp-340 is differentially regulated in epithelial cell lines by phorbol ester.
Clinical and experimental immunology 2002;130(3):449-58.
2002: Soren Hansen; Dorte Holm; Vivi Moeller; Lars Vitved; Christian Bendixen; Kenneth B M Reid; Karsten Skjoedt; Uffe Holmskov
CL-46, a novel collectin highly expressed in bovine thymus and liver.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5726-34.
2002: Jan Mollenhauer; Hanna Müller; Gaby Kollender; Stefan Lyer; Laura Diedrichs; Burkhard Helmke; Uffe Holmskov; Toon Ligtenberg; Stephan Herbertz; Inge Krebs; Jens Madsen; Floris J Bikker; Liane Schmitt; Stefan Wiemann; Wolfram Scheurlen; Herwart F Otto; Andreas von Deimling; Annemarie Poustka
The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer.
Genes, chromosomes & cancer 2002;35(3):242-55.
2002: Hanne Cathrine Bisgaard; Uffe Holmskov; Eric Santoni-Rugiu; Péter Nagy; Ole Nielsen; Peter Ott; Ester Hage; Kim Dalhoff; Lene Juel Rasmussen; Niels Tygstrup
Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1.
The American journal of pathology 2002;161(4):1187-98.
2002: Jan Mollenhauer; Burkhard Helmke; Hanna Müller; Gaby Kollender; Stefan Lyer; Laura Diedrichs; Uffe Holmskov; Toon Ligtenberg; Stephan Herbertz; Inge Krebs; Stefan Wiemann; Jens Madsen; Floris J Bikker; Liane Schmitt; Herwart F Otto; Annemarie Poustka
Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomas.
Genes, chromosomes & cancer 2002;35(2):164-9.
2002: Søren Hansen; Uffe Holmskov
Lung surfactant protein D (SP-D) and the molecular diverted descendants: conglutinin, CL-43 and CL-46.
Immunobiology 2002;205(4-5):498-517.
2002: Soren Hansen; Vivi Moeller; Dorte Holm; Lars Vitved; Christian Bendixen; Karsten Skjodt; Uffe Holmskov
Novel characterisation of the gene encoding conglutinin reveals that previously characterised promoter corresponds to the CL-43 promoter.
Molecular immunology 2002;39(1-2):39-43.
2002: Kevan L Hartshorn; Uffe Holmskov; Soren Hansen; Pengnian Zhang; Joseph Meschi; Tirsit Mogues; Mitchell R White; Erika C Crouch
Distinctive anti-influenza properties of recombinant collectin 43.
The Biochemical journal 2002;366(Pt 1):87-96.
2002: Steffen Husby; Anne Maria Herskind; Jens Christian Jensenius; Uffe Holmskov
Heritability estimates for the constitutional levels of the collectins mannan-binding lectin and lung surfactant protein D. A study of unselected like-sexed mono- and dizygotic twins at the age of 6-9 years.
Immunology 2002;106(3):389-94.
2002: Floris J Bikker; Antoon J M Ligtenberg; Jacqueline E van der Wal; P A M van den Keijbus; Uffe Holmskov; Enno C I Veerman; Arie V Nieuw Amerongen
Immunohistochemical detection of salivary agglutinin/gp-340 in human parotid, submandibular, and labial salivary glands.
Journal of dental research 2002;81(2):134-9.
2002: Jan Mollenhauer; Burkhard Helmke; Hanna Müller; Gaby Kollender; Inge Krebs; Stefan Wiemann; Uffe Holmskov; Jens Madsen; Herwart F Otto; Annemarie Poustka
An integrative model on the role of DMBT1 in epithelial cancer.
Cancer detection and prevention 2002;26(4):266-74.
2001: Jan Mollenhauer; Stephan Herbertz; Burkhard Helmke; Gaby Kollender; Inge Krebs; Jens Madsen; Uffe Holmskov; K Sorger; Liane Schmitt; Stefan Wiemann; Herwart F Otto; Hermann-Josef Gröne; Annemarie Poustka
Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer.
Cancer research 2001;61(24):8880-6.
2001: Toon Ligtenberg; Floris J Bikker; Jasper Groenink; Ida Tornoe; Rikke Leth-Larsen; Enno C I Veerman; Arie V Nieuw Amerongen; Uffe Holmskov
Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340.
The Biochemical journal 2001;359(Pt 1):243-8.
2000: J Gronlund; Lars Vitved; Mette Lausen; Karsten Skjodt; Uffe Holmskov
Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6406-15.
2000: T Berg; Rikke Leth-Larsen; Uffe Holmskov; Peter Højrup
Structural characterisation of human proteinosis surfactant protein A.
Biochimica et biophysica acta 2000;1543(1):159-73.
2000: Lars Vitved; Uffe Holmskov; Claus Koch; Børge Teisner; Soren Hansen; Jan Salomonsen; Karsten Skjødt
The homologue of mannose-binding lectin in the carp family Cyprinidae is expressed at high level in spleen, and the deduced primary structure predicts affinity for galactose.
Immunogenetics 2000;51(11):955-64.
2000: Jens Madsen; Anette Kliem; Ida Tornoe; Karsten Skjodt; Claus Koch; Uffe Holmskov
Localization of lung surfactant protein D on mucosal surfaces in human tissues.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(11):5866-70.
2000: Jan Mollenhauer; Stephan Herbertz; Uffe Holmskov; M Tolnay; Inge Krebs; A Merlo; H D Schrøder; D Maier; Frank Breitling; Stefan Wiemann; Hermann-Josef Gröne; Annemarie Poustka
DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer.
Cancer research 2000;60(6):1704-10.
2000: S Hansen; Steffen Thiel; A Willis; Uffe Holmskov; Jens C Jensenius
Purification and characterization of two mannan-binding lectins from mouse serum.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2610-8.
2000: Cordula M Stover; J Schleypen; J Grønlund; Michael R Speicher; Wilhelm J Schwaeble; Uffe Holmskov
Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.
Cytogenetics and cell genetics 2000;90(3-4):246-7.
2000: Uffe Holmskov
Collectins and collectin receptors in innate immunity.
APMIS. Supplementum 2000;100():1-59.
1999: Mette Lausen; N Lynch; Anders Schlosser; Ida Tornoe; S G Saekmose; Børge Teisner; A C Willis; Erika Crouch; Wilhelm J Schwaeble; Uffe Holmskov
Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D.
The Journal of biological chemistry 1999;274(45):32234-40.
1999: Jan Mollenhauer; Uffe Holmskov; Stefan Wiemann; Inge Krebs; Stephan Herbertz; Jens Madsen; Petra Kioschis; Johannes F Coy; Annemarie Poustka
The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability.
Oncogene 1999;18(46):6233-40.
1999: Uffe Holmskov
Lung surfactant proteins (SP-A and SP-D) in non-adaptive host responses to infection.
Journal of leukocyte biology 1999;66(5):747-52.
1999: Rikke Leth-Larsen; Uffe Holmskov; Peter Højrup
Structural characterization of human and bovine lung surfactant protein D.
The Biochemical journal 1999;343 Pt 3():645-52.
1999: Uffe Holmskov; Jan Mollenhauer; Jens Madsen; Lars Vitved; J Gronlund; Ida Tornoe; Anette Kliem; Kenneth B M Reid; Annemarie Poustka; Karsten Skjodt
Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(19):10794-9.
1999: PR Lawson; V C Perkins; Uffe Holmskov; Kenneth B M Reid
Genomic organization of the mouse gene for lung surfactant protein D.
American journal of respiratory cell and molecular biology 1999;20(5):953-63.
1998: Uffe Holmskov; J C Jensenius; Ida Tornøe; Peter Løvendahl
The plasma levels of coglutinin are heritable in cattle and low levels predispose to infection.
Immunology 1998;93(3):431-6.
1997: Charlotte H Jensen; TN Krogh; René K Støving; Uffe Holmskov; Børge Teisner
Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function.
Clinica chimica acta; international journal of clinical chemistry 1997;268(1-2):1-20.
1997: Uffe Holmskov; P Lawson; Børge Teisner; Ida Tornoe; A C Willis; C Morgan; Claus Koch; Kenneth B M Reid
Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.
The Journal of biological chemistry 1997;272(21):13743-9.
1997: Steffen Thiel; Thomas Vorup-Jensen; Cordula M Stover; Wilhelm J Schwaeble; S B Laursen; K Poulsen; A C Willis; P Eggleton; S Hansen; Uffe Holmskov; KB Reid; Jens C Jensenius
A second serine protease associated with mannan-binding lectin that activates complement.
Nature 1997;386(6624):506-10.
1996: Uffe Holmskov; P B Fischer; A Rothmann; Peter Højrup
Affinity and kinetic analysis of the bovine plasma C-type lectin collectin-43 (CL-43) interacting with mannan.
FEBS letters 1996;393(2-3):314-6.
1996: Boon L Lim; Uffe Holmskov
Expression of the carbohydrate recognition domain of bovine conglutinin and demonstration of its binding to iC3b and yeast mannan.
Biochemical and biophysical research communications 1996;218(1):260-6.
1995: Uffe Holmskov; Steen B Laursen; R Malhotra; H Wiedemann; R Timpl; G R Stuart; Ida Tornøe; P S Madsen; Kenneth B M Reid; Jens C Jensenius
Comparative study of the structural and functional properties of a bovine plasma C-type lectin, collectin-43, with other collectins.
The Biochemical journal 1995;305 ( Pt 3)():889-96.
1994: Boon L Lim; J Y Wang; Uffe Holmskov; Hans Hoppe; Kenneth B M Reid
Expression of the carbohydrate recognition domain of lung surfactant protein D and demonstration of its binding to lipopolysaccharides of gram-negative bacteria.
Biochemical and biophysical research communications 1994;202(3):1674-80.
1994: R Malhotra; J Lu; Uffe Holmskov; Robert B Sim
Collectins, collectin receptors and the lectin pathway of complement activation.
Clinical and experimental immunology 1994;97 Suppl 2():4-9.
1994: Boon L Lim; Antony C Willis; Kenneth B M Reid; J Lu; Steen B Laursen; Jens C Jensenius; Uffe Holmskov
Primary structure of bovine collectin-43 (CL-43). Comparison with conglutinin and lung surfactant protein-D.
The Journal of biological chemistry 1994;269(16):11820-4.
1994: Steen B Laursen; Steffen Thiel; Børge Teisner; Uffe Holmskov; Y Wang; Robert B Sim; Jens C Jensenius
Bovine conglutinin binds to an oligosaccharide determinant presented by iC3b, but not by C3, C3b or C3c.
Immunology 1994;81(4):648-54.
1994: P Holt; Uffe Holmskov; Steffen Thiel; Børge Teisner; Peter Højrup; Jens C Jensenius
Purification and characterization of mannan-binding protein from mouse serum.
Scandinavian journal of immunology 1994;39(2):202-8.
1994: Jens C Jensenius; Steen B Laursen; Y Zheng; Uffe Holmskov
Conglutinin and CL-43, two collagenous C-type lectins (collectins) in bovine serum.
Biochemical Society transactions 1994;22(1):95-100.
1993: Uffe Holmskov; Jens C Jensenius
Structure and function of collectins: humoral C-type lectins with collagenous regions.
Behring Institute Mitteilungen 1993;(93):224-35.
1993: J Lu; H Wiedemann; Uffe Holmskov; Steffen Thiel; R Timpl; Kenneth B M Reid
Structural similarity between lung surfactant protein D and conglutinin. Two distinct, C-type lectins containing collagen-like sequences.
European journal of biochemistry / FEBS 1993;215(3):793-9.
1993: Uffe Holmskov; Børge Teisner; Antony C Willis; Kenneth B M Reid; Jens C Jensenius
Purification and characterization of a bovine serum lectin (CL-43) with structural homology to conglutinin and SP-D and carbohydrate specificity similar to mannan-binding protein.
The Journal of biological chemistry 1993;268(14):10120-5.
1993: Uffe Holmskov; P Holt; Kenneth B M Reid; Antony C Willis; Børge Teisner; Jens C Jensenius
Purification and characterization of bovine mannan-binding protein.
Glycobiology 1993;3(2):147-53.
1992: Steffen Thiel; Uffe Holmskov; L Hviid; Steen B Laursen; Jens C Jensenius
The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response.
Clinical and experimental immunology 1992;90(1):31-5.
1992: Uffe Holmskov; Børge Teisner; N T Pedersen; Steen B Laursen; H B Rasmussen; Jens C Jensenius
Tissue localization of conglutinin, a bovine C-type lectin.
Immunology 1992;76(1):169-73.