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Florian Holsboer

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Jimena Druker; Juan Gerez; Florian Holsboer; Jorge A Iniguez-Lluhi; Ana C Liberman; Marcelo Paez-Pereda; Theo Rein; María Antunica-Noguerol; Eduardo Arzt
RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity.
A Menke; Hildegard Pfister; J Rubel; Manfred Uhr; Tanja Brückl; Florian Holsboer; T Klengel; Susanne Lucae; Elisabeth B Binder
Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.
Juan J Bonfiglio; Damiana Giacomini; Florian Holsboer; Carolina Inda; Giuseppina Maccarrone; Damian Refojo; Sergio Senin; Eduardo Arzt; Christoph W Turck; Susana Silberstein
B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.

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2013: Jimena Druker; Juan Gerez; Florian Holsboer; Jorge A Iniguez-Lluhi; Ana C Liberman; Marcelo Paez-Pereda; Theo Rein; María Antunica-Noguerol; Eduardo Arzt
RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity.
Molecular and cellular biology 2013;33(11):2116-27.
2013: A Menke; Hildegard Pfister; J Rubel; Manfred Uhr; Tanja Brückl; Florian Holsboer; T Klengel; Susanne Lucae; Elisabeth B Binder
Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.
Genes, brain, and behavior 2013;12(3):289-96.
2013: Juan J Bonfiglio; Damiana Giacomini; Florian Holsboer; Carolina Inda; Giuseppina Maccarrone; Damian Refojo; Sergio Senin; Eduardo Arzt; Christoph W Turck; Susana Silberstein
B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.
Molecular endocrinology (Baltimore, Md.) 2013;27(3):491-510.
2013: Christian Webhofer; Walter Zieglgänsberger; John M Asara; Philipp Gormanns; Florian Holsboer; Maria Lebar; Tonia Ludwig; Giuseppina Maccarrone; Benno Pütz; Stefan Reckow; Inge Sillaber; Christoph W Turck
Proteomic and metabolomic profiling reveals time-dependent changes in hippocampal metabolism upon paroxetine treatment and biomarker candidates.
Journal of psychiatric research 2013;47(3):289-98.
2013: Klaus V Wagner; Xiao-Dong Wang; Miriam Wolf; Nils C Gassen; Jakob Hartmann; Florian Holsboer; Christiana Labermaier; Claudia Liebl; Katharina Mangold; Marianne B Müller; Theo Rein; Mathias V Schmidt
Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(9):3857-64.
2013: Stephany Fulda; Tatjana Dose; Florian Holsboer; Stefan Kloiber; Susanne Lucae; Ludwig Schaaf; Johannes Hennings
Mirtazapine Provokes Periodic Leg Movements during Sleep in Young Healthy Men.
Sleep 2013;36(5):661-9.
2013: Julien Dine; Matthias Eder; Florian Holsboer; Irina A Ionescu; Rainer Landgraf; Jens Stepan; Yi-Chun Yen; Ulrike Schmidt
Identification of a role for the ventral hippocampus in neuropeptide s-elicited anxiolysis.
PloS one 2013;8(3):e60219.
2013: Juan Gerez; Florian Holsboer; Marcelo Paez-Pereda; Gustavo Sevlever; Susana Silberstein; Lucas Tedesco; Adrián G Turjanski; Mercedes B Fuertes; Eduardo Arzt
In silico structural and functional characterization of the RSUME splice variants.
PloS one 2013;8(2):e57795.
2013: Torsten Klengel; Helen S Mayberg; Divya Mehta; Kristina B Mercer; Charles B Nemeroff; Thaddeus W W Pace; Carmine M Pariante; Jens C Pruessner; Theo Rein; Kerry J Ressler; Monika Rex-Haffner; Christoph Anacker; Bekh Bradley; Christine M Heim; Florian Holsboer; Elisabeth B Binder
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.
Nature neuroscience 2013;16(1):33-41.
2012: Felix Hausch; Florian Holsboer
The seven pillars of molecular pharmacology: GPCR research honored with Nobel Prize for chemistry.
Angewandte Chemie (International ed. in English) 2012;51(49):12172-5.
2012: Klaus V Wagner; Xiao-Dong Wang; Manfred Uhr; Jakob Hartmann; Florian Holsboer; Christiana Labermaier; Claudia Liebl; Daria Marinescu; Marianne B Müller; Sebastian H Scharf; Mathias V Schmidt
Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(13):2797-808.
2012: Jakob Hartmann; Felix Hausch; Florian Holsboer; Daria Marinescu; Marianne B Müller; Theo Rein; Sebastian H Scharf; Nina Dedic; Jan M Deussing; Ulrike Schmidt; Klaus V Wagner; Xiao-Dong Wang; Mathias V Schmidt
Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice.
Psychoneuroendocrinology 2012;37(12):2009-21.
2012: Nicole Zimmermann; Jürgen Zschocke; Florian Holsboer; Tatjana Perisic; Shuang Yu; Theo Rein
Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels.
The Biochemical journal 2012;448(1):93-102.
2012: Felix Hausch; Florian Holsboer
Structural biology: Snapshot of an activated peptide receptor.
Nature 2012;490(7421):492-3.
2012: Cornelia Graf; Florian Holsboer; Claudia Kuehne; Markus Panhuysen; Benno Pütz; Peter Weber; Wolfgang Wurst; Jan M Deussing
Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells.
Molecular and cellular endocrinology 2012;362(1-2):29-38.
2012: Victor I Spoormaker; Thomas C Wetter; Kátia C Andrade; Martin Dresler; Roberto Goya-Maldonado; Florian Holsboer; Sara A Kiem; Philipp G Sämann; Manuel S Schröter; Michael Czisch
Effects of rapid eye movement sleep deprivation on fear extinction recall and prediction error signaling.
Human brain mapping 2012;33(10):2362-76.
2012: Tatjana Perisic; Theo Rein; Florian Holsboer; Jürgen Zschocke
The CpG island shore of the GLT-1 gene acts as a methylation-sensitive enhancer.
Glia 2012;60(9):1345-55.
2012: Xiao-Dong Wang; Wolfgang Wurst; Jan M Deussing; Florian Holsboer; Christiana Labermaier; Marianne B Müller; Mathias V Schmidt
Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1.
The European journal of neuroscience 2012;36(3):2360-7.
2012: Stefan Kloiber; Bertram Müller-Myhsok; Darina Czamara; Johannes Hennings; Florian Holsboer; Nazanin Karbalai; Susanne Lucae
ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples.
Journal of psychiatric research 2012;46(8):973-9.
2012: Mathias V Schmidt; Florian Holsboer; Marcelo Paez-Pereda; Felix Hausch
The prospect of FKBP51 as a drug target.
ChemMedChem 2012;7(8):1351-9.
2012: Martin Dresler; Florian Holsboer; Stefan P Koch; Hellmuth Obrig; Philipp G Sämann; Victor I Spoormaker; Axel Steiger; Renate Wehrle; Michael Czisch
Neural correlates of dream lucidity obtained from contrasting lucid versus non-lucid REM sleep: a combined EEG/fMRI case study.
Sleep 2012;35(7):1017-20.
2012: Nina Dedic; Martin Ableitner; Florian Holsboer; Mayumi Kimura; Claudia Kühne; Ailing Lu; Cristoph P Romanowski; Marcel Schieven; Chadi Touma; Wolfgang Wurst; Jan M Deussing
Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice.
Cellular and molecular neurobiology 2012;32(5):815-28.
2012: Guy Griebel; Florian Holsboer
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Nature reviews. Drug discovery 2012;11(6):462-78.
2012: F Weber; C Wolf; Florian Holsboer; B Müller-Myhsok; M Uhr; Achim Berthele; Thomas Bettecken; D Buck; Sabine Cepok; H P Hartung; B Hemmer
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients.
The pharmacogenomics journal 2012;12(3):238-45.
2012: Irina A Ionescu; Rainer Landgraf; Yi-Chun Yen; Dominik R Buell; Julien Dine; Matthias Eder; Leonie Herrmann; Florian Holsboer; Ulrike Schmidt
Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(6):1323-37.
2012: Andreas Menke; Bertram Müller-Myhsok; Benno Pütz; Monika Rex-Haffner; Jennifer Rubel; Manfred Uhr; Peter Weber; Jan M Deussing; Mariya Gonik; Florian Holsboer; Torsten Klengel; Susanne Lucae; Divya Mehta; Janine Arloth; Elisabeth B Binder
Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(6):1455-64.
2012: Franziska Degenhardt; Magdalena Gross; Andreas Heinz; Stefan Herms; Per Hoffmann; Florian Holsboer; Christoph Lange; Susanne Lucae; Wolfgang Maier; Manuel Mattheisen; Sandra Meier; Andreas Meyer-Lindenberg; Susanne Moebus; Thomas W Mühleisen; Bertram Müller-Myhsok; Markus M Nöthen; Lutz Priebe; Marcella Rietschel; Jana Strohmaier; Henrik Walter; Christiane Wolf; René Breuer; Sven Cichon
Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2012;159B(3):263-73.
2012: Ana C Liberman; Damian Refojo; Maria Antunica-Noguerol; Florian Holsboer; Eduardo Arzt
Underlying mechanisms of cAMP- and glucocorticoid-mediated inhibition of FasL expression in activation-induced cell death.
Molecular immunology 2012;50(4):220-35.
2012: Andreas Menke; Bertram Müller-Myhsok; Philipp G Sämann; Darina Czamara; Michael Czisch; Angela Heck; Johannes Hennings; Florian Holsboer; Stefan Kloiber; Martin A Kohli; Susanne Lucae; Elisabeth B Binder
Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes.
Psychoneuroendocrinology 2012;37(4):565-75.
2012: Claudia Ditzen; Florian Holsboer; Archana M Jastorff; Giuseppina Maccarrone; Christine A Miller; Ning Tang; Larysa Teplytska; Manfred Uhr; Alexander Yassouridis; Thomas Bronisch; Christoph W Turck
Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(4):1013-25.
2012: Becky Inkster; Andrew Kertesz; Inge Loy-English; Dorothee P Auer; Michael Borrie; Nicola Filippini; Rachel A Gibson; Danilo A Guzman; Florian Holsboer; Emilio Merlo Pich; Pierandrea Muglia; Thomas E Nichols; Anil W Rao; Khanum Ridler; Philipp G Saemann; Federica Tozzi; Sally Wetten; Brandon Whitcher; Julie Williams; Paul M Matthews
Genetic variation in GOLM1 and prefrontal cortical volume in Alzheimer's disease.
Neurobiology of aging 2012;33(3):457-65.
2012: Elisabeth B Binder; Florian Holsboer
Low cortisol and risk and resilience to stress-related psychiatric disorders.
Biological psychiatry 2012;71(4):282-3.
2012: Alana Knapman; Rainer Landgraf; Daniel Martins-de-Souza; Michael Czisch; Florian Holsboer; Sebastian F Kaltwasser; Christoph W Turck; Chadi Touma
Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism.
The European journal of neuroscience 2012;35(3):412-22.
2012: Mariya Gonik; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Bertram Müller-Myhsok; Benno Pütz; Chadi Touma; Yi-Chun Yen; Thomas Bettecken; Mirjam Bunck; Darina Czamara; Elisabeth Frank; Ludwig Czibere
The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety.
BMC genomics 2012;13():579.
2012: K Ganea; D Harbich; Florian Holsboer; C Liebl; Susanne Lucae; A Menke; Gerhard Rammes; Mathias V Schmidt; Inge Sillaber; V Sterlemann; Corinna Storch; Manfred Uhr; E B Binder; Marianne B Müller
Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response.
Translational psychiatry 2012;2():e177.
2012: Leonie Herrmann; Florian Holsboer; Irina A Ionescu; Dominik R Buell; Yulia Golub; Kathrin Henes; Nancy Xin Ru Wang; Carsten T Wotjak; Ulrike Schmidt
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
PloS one 2012;7(8):e42603.
2012: Anup G Pillai; Danielle de Jong; Jan-Michael Heinzmann; Florian Holsboer; Marian Joëls; Sofia Kanatsou; Alana Knapman; Harm Krugers; Rainer Landgraf; Chadi Touma
Dendritic morphology of hippocampal and amygdalar neurons in adolescent mice is resilient to genetic differences in stress reactivity.
PloS one 2012;7(6):e38971.
2012: Jens Plag; Lena Pyrkosch; Katharina Gaudlitz; Florian Holsboer; André Wittmann; Alexander Yassouridis; Elisabeth Zschucke; Andreas Ströhle
Distinct panicogenic activity of sodium lactate and cholecystokinin tetrapeptide in patients with panic disorder.
Current pharmaceutical design 2012;18(35):5619-26.
2012: Michael Czisch; Helga A Harsay; Florian Holsboer; Philipp G Sämann; Renate Wehrle; Thomas C Wetter; Sean P A Drummond
On the Need of Objective Vigilance Monitoring: Effects of Sleep Loss on Target Detection and Task-Negative Activity Using Combined EEG/fMRI.
Frontiers in neurology 2012;3():67.
2012: Ana C Liberman; Joao Palermo-Neto; Marcelo J Perone; Maria Antunica-Noguerol; Carla N Castro; Karolien De Bosscher; Jimena Druker; Viviane Ferraz-de-Paula; Sarah Gerlo; Guy Haegeman; Florian Holsboer; Eduardo Arzt
Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.
PloS one 2012;7(4):e35155.
2012: Jakob Hartmann; Felix Hausch; Florian Holsboer; Claudia Liebl; Marianne B Müller; Theo Rein; Sebastian H Scharf; Ulrike Schmidt; David F Smith; Chadi Touma; Klaus V Wagner; Xiao-Dong Wang; Miriam Wolf; Joyce Cheung-Flynn; Marc Cox; Mathias V Schmidt
The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.
Neuropharmacology 2012;62(1):332-9.
2011: Yaoyang Zhang; Michaela D Filiou; Elisabeth Frank; Philipp Gormanns; Boris Hambsch; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Giuseppina Maccarrone; Stefan Reckow; Christoph W Turck
Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways.
Molecular & cellular proteomics : MCP 2011;10(12):M111.008110.
2011: Michaela D Filiou; Elisabeth Frank; Philipp Gormanns; Boris Hambsch; Florian Holsboer; Melanie Keßler; Rainer Landgraf; Tonia Ludwig; Giuseppina Maccarrone; Markus Nussbaumer; Stefan Reckow; Larysa Teplytska; Alexander Yassouridis; Yaoyang Zhang; Mirjam Bunck; Christoph W Turck
Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways.
Biological psychiatry 2011;70(11):1074-82.
2011: Chadi Touma; Mathias V Schmidt; Ulrike Schmidt; Anna Siebertz; Dominik R Büll; Joyce Cheung-Flynn; Marc Cox; Anna-Mareike Depping; Nils Christian Gassen; Jakob Hartmann; Felix Hausch; Jan-Michael Heinzmann; Leonie Herrmann; Florian Holsboer; Irina A Ionescu; Marcus Ising; Alana Knapman; Theo Rein
FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior.
Biological psychiatry 2011;70(10):928-36.
2011: Martin Dresler; Florian Holsboer; Stefan P Koch; Hellmuth Obrig; Philipp G Sämann; Victor I Spoormaker; Axel Steiger; Renate Wehrle; Michael Czisch
Dreamed movement elicits activation in the sensorimotor cortex.
Current biology : CB 2011;21(21):1833-7.
2011: Mathias V Schmidt; Jan-Philip Schülke; Michael G Stewart; Michael Stiess; Dietrich Trümbach; Christoph Turck; Gabriela M Wochnik; Wolfgang Wurst; Walter Zieglgänsberger; Nicole Zimmermann; Charilaos Avrabos; Jörg Bock; Frank Bradke; Heather A Davies; Matthias Eder; Florian Holsboer; Claudia Liebl; Marianne B Müller; Sebastian H Scharf; Theo Rein
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17213-8.
2011: Petra Zimmermann; Elisabeth B Binder; Tanja Brückl; Avshalom Caspi; Florian Holsboer; Roselind Lieb; Terrie E Moffitt; Agnes Nocon; Hildegard Pfister; Manfred Uhr; Marcus Ising
Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study.
The American journal of psychiatry 2011;168(10):1107-16.
2011: Becky Inkster; Dorothee P Auer; Florian Holsboer; Emilio Merlo Pich; Pierandrea Muglia; Thomas E Nichols; Anil W Rao; Khanum Ridler; Philipp G Saemann; Federica Tozzi; Paul M Matthews
Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms.
Journal of neuroimaging : official journal of the American Society of Neuroimaging 2011;21(4):375-82.
2011: Damian Refojo; Marion Schumacher; Günther Schütz; Martin Schweizer; Inge Sillaber; Christoph K Thoeringer; Chadi Touma; Annette M Vogl; Gregor von Wolff; Carsten T Wotjak; Wolfgang Wurst; Matthias Eder; Stefanie Ehrenberg; David Engblom; Florian Holsboer; Claudia Kuehne; Klaus-Armin Nave; Charilaos Avrabos; Nina Dedic; Jan M Deussing
Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.
Science (New York, N.Y.) 2011;333(6051):1903-7.
2011: Xiao-Dong Wang; Miriam Wolf; Wolfgang Wurst; Michael G Stewart; Tallie Z Baram; Jan M Deussing; Florian Holsboer; Igor Kraev; Claudia Liebl; Marianne B Müller; Gerhard Rammes; Courtney J Rice; Sebastian H Scharf; Mathias V Schmidt
Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(38):13625-34.
2011: Divya Mehta; Andreas Menke; Kristina B Mercer; Bertram Müller-Myhsok; Benno Pütz; Kerry J Ressler; Monika Rex-Haffner; Jennifer Rubel; Bekh Bradley; Mariya Gonik; Florian Holsboer; Torsten Klengel; Elisabeth B Binder
Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.
Archives of general psychiatry 2011;68(9):901-10.
2011: Philipp G Sämann; Victor I Spoormaker; Carolin Tully; Renate Wehrle; David Hoehn; Florian Holsboer; Henning Peters; Michael Czisch
Development of the brain's default mode network from wakefulness to slow wave sleep.
Cerebral cortex (New York, N.Y. : 1991) 2011;21(9):2082-93.
2011: Jeeva Varadarajulu; Maria Lebar; Gurumoorthy Krishnamoorthy; Sonja Habelt; Jia Lu; I Bernard Weinstein; Haiyang Li; Florian Holsboer; Christoph W Turck; Chadi Touma
Increased anxiety-related behaviour in Hint1 knockout mice.
Behavioural brain research 2011;220(2):305-11.
2011: Magdalena C Denk; Angelika Erhardt-Lehmann; Florian Holsboer; Christiane Rewerts; Christoph W Turck
Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation.
The American journal of psychiatry 2011;168(7):751-2.
2011: Jürgen Zschocke; Nicole Zimmermann; B Berning; Vanessa Ganal; Florian Holsboer; Theo Rein
Antidepressant drugs diversely affect autophagy pathways in astrocytes and neurons--dissociation from cholesterol homeostasis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(8):1754-68.
2011: Philipp Gormanns; Florian Holsboer; Nikola S Mueller; Claudia Ditzen; Simone Wolf; Christoph W Turck
Phenome-transcriptome correlation unravels anxiety and depression related pathways.
Journal of psychiatric research 2011;45(7):973-9.
2011: Luanna Dixson; Khanum Ridler; Thomas E Nichols; Philipp G Saemann; Dorothee P Auer; Florian Holsboer; Pierandrea Muglia; Paul M Matthews; Becky Inkster
Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls.
Psychoneuroendocrinology 2011;36(6):929-34.
2011: Xiao-Dong Wang; Yuncai Chen; Miriam Wolf; Klaus V Wagner; Claudia Liebl; Sebastian H Scharf; Daniela Harbich; Bianca Mayer; Wolfgang Wurst; Florian Holsboer; Jan M Deussing; Tallie Z Baram; Marianne B Müller; Mathias V Schmidt
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.
Neurobiology of disease 2011;42(3):300-10.
2011: S Nischwitz; Sabine Cepok; A Kroner; C Wolf; M Knop; F Müller-Sarnowski; Hildegard Pfister; P Rieckmann; B Hemmer; Marcus Ising; Manfred Uhr; Thomas Bettecken; Florian Holsboer; Bertram Müller-Myhsok; F Weber
More CLEC16A gene variants associated with multiple sclerosis.
Acta neurologica Scandinavica 2011;123(6):400-6.
2011: Yulia Golub; Sebastian F Kaltwasser; Christoph P Mauch; Leonie Herrmann; Ulrike Schmidt; Florian Holsboer; Michael Czisch; Carsten T Wotjak
Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder.
Journal of psychiatric research 2011;45(5):650-9.
2011: Marcelo Paez-Pereda; Felix Hausch; Florian Holsboer
Corticotropin releasing factor receptor antagonists for major depressive disorder.
Expert opinion on investigational drugs 2011;20(4):519-35.
2011: Tony Kam-Thong; Darina Czamara; Koji Tsuda; Karsten Borgwardt; Cathryn M Lewis; Angelika Erhardt-Lehmann; Bernhard Hemmer; Peter Rieckmann; Markus Daake; Frank Weber; Christiane Wolf; Andreas Ziegler; Benno Pütz; Florian Holsboer; Bernhard Schölkopf; Bertram Müller-Myhsok
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units.
European journal of human genetics : EJHG 2011;19(4):465-71.
2011: Juan J Bonfiglio; Giuseppina Maccarrone; Christiane Rewerts; Florian Holsboer; Eduardo Arzt; Christoph W Turck; Susana Silberstein
Characterization of the B-Raf interactome in mouse hippocampal neuronal cells.
Journal of proteomics 2011;74(2):186-98.
2011: Gregor von Wolff; Charilaos Avrabos; Jens Stepan; Wolfgang Wurst; Jan M Deussing; Florian Holsboer; Matthias Eder
Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation.
Journal of psychiatric research 2011;45(2):256-61.
2011: Ludwig Czibere; Nafees Ahmad; Laura A Baur; Mirjam Bunck; Katja Gemmeke; Cornelia Graf; Boris Hambsch; Florian Holsboer; Claudia Kühne; Rainer Landgraf; Markus Panhuysen; Christoph Peters; Benno Pütz; Thomas Reinheckel; Gabriele Rieder; Andrea Steiner; Peter Weber; Regina Widner; Anke Wittmann; Jan M Deussing
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.
PloS one 2011;6(8):e23604.
2011: Shuang Yu; Florian Holsboer; Nuno Sousa; Silei Yang; Osborne F X Almeida
Glucocorticoid regulation of astrocytic fate and function.
PloS one 2011;6(7):e22419.
2011: Juan José Bonfiglio; Florian Holsboer; Carolina Inda; Damian Refojo; Eduardo Arzt; Susana Silberstein
The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved.
Neuroendocrinology 2011;94(1):12-20.
2011: Casey Sarapas; Guiqing Cai; Linda M Bierer; Julia A Golier; Sandro Galea; Marcus Ising; Theo Rein; James Schmeidler; Bertram Müller-Myhsok; Manfred Uhr; Florian Holsboer; Joseph Buxbaum; Rachel Yehuda
Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks.
Disease markers 2011;30(2-3):101-10.
2011: Ulrike Schmidt; Florian Holsboer; Theo Rein
Epigenetic aspects of posttraumatic stress disorder.
Disease markers 2011;30(2-3):77-87.
2011: Thomas Fenzl; Chadi Touma; Christoph Pn Romanowski; Jörg Ruschel; Florian Holsboer; Rainer Landgraf; Mayumi Kimura; Alexander Yassouridis
Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression.
BMC neuroscience 2011;12():29.
2011: Verena Henkel; Florian Seemüller; M Obermeier; Mazda Adli; M Bauer; K Kronmüller; Florian Holsboer; Peter Brieger; Gerd Laux; W Bender; I Heuser; Joachim Zeiler; Wolfgang Gaebel; A Mayr; Michael Riedel; Hans-Jürgen Möller
Relationship between baseline severity of depression and antidepressant treatment outcome.
Pharmacopsychiatry 2011;44(1):27-32.
2011: Boadie W Dunlop; Yara Betancourt; Elisabeth B Binder; Christine Heim; Florian Holsboer; Marcus Ising; Melissa McKenzie; Tanja Mletzko; Hildegard Pfister; Charles Nemeroff; W. Edward Craighead; Helen S Mayberg
Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder.
Journal of psychiatric research 2011;45(1):24-8.
2010: Mathias V Schmidt; Dietrich Trümbach; Peter Weber; Klaus Wagner; Sebastian H Scharf; Claudia Liebl; Nicole Datson; Christian Namendorf; Tamara Gerlach; Claudia Kühne; Manfred Uhr; Jan M Deussing; Wolfgang Wurst; Elisabeth B Binder; Florian Holsboer; Marianne B Müller
Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(50):16949-58.
2010: Philipp G Sämann; Carolin Tully; Victor I Spoormaker; Thomas C Wetter; Florian Holsboer; Renate Wehrle; Michael Czisch
Increased sleep pressure reduces resting state functional connectivity.
Magma (New York, N.Y.) 2010;23(5-6):375-89.
2010: Victor I Spoormaker; A Sturm; K C Andrade; M S Schröter; R Goya-Maldonado; Florian Holsboer; Thomas C Wetter; Philipp G Sämann; Michael Czisch
The neural correlates and temporal sequence of the relationship between shock exposure, disturbed sleep and impaired consolidation of fear extinction.
Journal of psychiatric research 2010;44(16):1121-8.
2010: Becky Inkster; Thomas E Nichols; Philipp G Saemann; Dorothee P Auer; Florian Holsboer; Pierandrea Muglia; Paul Matthews
Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression.
NeuroImage 2010;53(3):908-17.
2010: Florian Seemüller; Hans-Jürgen Möller; Michael Obermeier; Mazda Adli; Michael Bauer; Klaus Kronmüller; Florian Holsboer; Peter Brieger; Gerd Laux; Wolfram Bender; Isabella Heuser; Joachim Zeiler; Wolfgang Gaebel; Rebecca Schennach-Wolff; Verena Henkel; Michael Riedel
Do efficacy and effectiveness samples differ in antidepressant treatment outcome? An analysis of eligibility criteria in randomized controlled trials.
The Journal of clinical psychiatry 2010;71(11):1425-33.
2010: J-M Heinzmann; Christoph K Thoeringer; Alana Knapman; Rupert Palme; Florian Holsboer; Manfred Uhr; Rainer Landgraf; Chadi Touma
Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study.
Journal of neuroendocrinology 2010;22(11):1187-97.
2010: Sandra Nischwitz; Sabine Cepok; Antje Kroner; Christiane Wolf; Matthias Knop; Felix Müller-Sarnowski; Hildegard Pfister; Darina Roeske; Peter Rieckmann; Bernhard Hemmer; Marcus Ising; Manfred Uhr; Thomas Bettecken; Florian Holsboer; Bertram Müller-Myhsok; Frank Weber
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
Journal of neuroimmunology 2010;227(1-2):162-6.
2010: Liqun Luo; Eugenio Rodriguez; Karim Jerbi; Jean-Philippe Lachaux; Jacques Martinerie; Maurizio Corbetta; Gordon L Shulman; Daniele Piomelli; Gina G Turrigiano; Sacha B Nelson; Marian Joëls; E Ronald de Kloet; Florian Holsboer; David M Amodio; Chris D Frith; Michelle L Block; Luigi Zecca; Jau-Shyong Hong; Robert Dantzer; Keith W Kelley; A D Craig
Ten years of Nature Reviews Neuroscience: insights from the highly cited.
Nature reviews. Neuroscience 2010;11(10):718-26.
2010: Rachel Yehuda; Janine D Flory; Laura C Pratchett; Joseph Buxbaum; Marcus Ising; Florian Holsboer
Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD.
Psychopharmacology 2010;212(3):405-17.
2010: Carsten Hohoff; Emma L Mullings; Susan V Heatherley; Christine M Freitag; Lisa C Neumann; Katharina Domschke; Petra Krakowitzky; Matthias Rothermundt; Martin E Keck; Erhardt Angelika; Paul G Unschuld; Christian Jacob; Jürgen Fritze; Borwin Bandelow; Wolfgang Maier; Florian Holsboer; Peter J Rogers; Jürgen Deckert
Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality.
Journal of psychiatric research 2010;44(14):930-7.
2010: Maik Dahlhoff; Anja Siegmund; Y Golub; Eckhard Wolf; Florian Holsboer; Carsten T Wotjak
AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms.
Neuroscience 2010;169(3):1216-26.
2010: Alana Knapman; J-M Heinzmann; Florian Holsboer; Rainer Landgraf; Chadi Touma
Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice.
Neurobiology of learning and memory 2010;94(2):145-52.
2010: Jan M Deussing; Johannes Breu; Claudia Kühne; Magdalena Kallnik; Mirjam Bunck; Lisa Glasl; Yi-Chun Yen; Mathias V Schmidt; Regine Zurmühlen; Annette M Vogl; Valérie Gailus-Durner; Helmut Fuchs; Sabine M Hölter; Carsten T Wotjak; Rainer Landgraf; Martin Hrabé De Angelis; Florian Holsboer; Wolfgang Wurst
Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(27):9103-16.
2010: Alana Knapman; J-M Heinzmann; Rainer Hellweg; Florian Holsboer; Rainer Landgraf; Chadi Touma
Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders.
Journal of psychiatric research 2010;44(9):566-75.
2010: C Ditzen; J Varadarajulu; Ludwig Czibere; M Gonik; B S Targosz; B Hambsch; Thomas Bettecken; Melanie Keßler; Elisabeth Frank; Mirjam Bunck; Larysa Teplytska; Erhardt Angelika; Florian Holsboer; Bertram Müller-Myhsok; Rainer Landgraf; Christoph W Turck
Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways.
Molecular psychiatry 2010;15(7):702-11.
2010: Stefan Kloiber; M A Kohli; T Brueckl; S Ripke; Marcus Ising; Manfred Uhr; A Menke; Paul G Unschuld; Sonja Horstmann; Daria Salyakina; Bertram Muller-Myhsok; Elisabeth B Binder; Florian Holsboer; Susanne Lucae
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression.
Molecular psychiatry 2010;15(7):736-47.
2010: Paul G Unschuld; Marcus Ising; Darina Roeske; Erhardt Angelika; Michael Specht; Stefan Kloiber; Manfred Uhr; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(7):1583-92.
2010: Caroline Nothdurfter; Sascha Tanasic; Barbara Di Benedetto; Gerhard Rammes; Eva-Maria Wagner; Thomas Kirmeier; Vanessa Ganal; Julia S Kessler; Theo Rein; Florian Holsboer; Rainer Rupprecht
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(7):1510-9.
2010: Mathias V Schmidt; S H Scharf; V Sterlemann; K Ganea; C Liebl; Florian Holsboer; Marianne B Müller
High susceptibility to chronic social stress is associated with a depression-like phenotype.
Psychoneuroendocrinology 2010;35(5):635-43.
2010: Florian Seemüller; Michael Riedel; Michael Obermeier; Michael Bauer; Mazda Adli; Klaus Kronmüller; Florian Holsboer; Peter Brieger; Gerd Laux; Wolfram Bender; Isabella Heuser; Joachim Zeiler; Wolfgang Gaebel; Eva Dichgans; Roland Bottländer; Richard Musil; Hans-Jürgen Möller
Outcomes of 1014 naturalistically treated inpatients with major depressive episode.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010;20(5):346-55.
2010: Christoph K Thoeringer; Erhardt Angelika; Inge Sillaber; M B Mueller; frauke ohl; Florian Holsboer; Martin E Keck
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.
Journal of psychopharmacology (Oxford, England) 2010;24(5):733-43.
2010: Christoph P N Romanowski; Thomas Fenzl; Cornelia Flachskamm; Wolfgang Wurst; Florian Holsboer; Jan M Deussing; Mayumi Kimura
Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice.
Sleep 2010;33(4):427-36.
2010: Martin A Kohli; Daria Salyakina; Andrea Pfennig; Susanne Lucae; Sonja Horstmann; Andreas Menke; Stefan Kloiber; Johannes Hennings; Bekh B Bradley; Kerry J Ressler; Manfred Uhr; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.
Archives of general psychiatry 2010;67(4):348-59.
2010: Mathias V Schmidt; S H Scharf; C Liebl; D Harbich; B Mayer; Florian Holsboer; Marianne B Müller
A novel chronic social stress paradigm in female mice.
Hormones and behavior 2010;57(4-5):415-20.
2010: Francis McMajon; Nirmala Akula; Thomas G. Schulze; Pierandrea Muglia; Federica Tozzi; Sevilla D Detera-Wadleigh; C J M Steele; René Breuer; Jana Strohmaier; Jens R Wendland; Manuel Mattheisen; Thomas W Mühleisen; Wolfgang Maier; Markus M Nöthen; Sven Cichon; Anne Farmer; John B Vincent; Florian Holsboer; Martin Preisig; Marcella Rietschel
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.
Nature genetics 2010;42(2):128-31.
2010: Sonja Horstmann; Susanne Lucae; Andreas Menke; Johannes M Hennings; Marcus Ising; Darina Roeske; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(3):727-40.
2010: Tatjana Perisic; Nicole Zimmermann; Thomas Kirmeier; Maria Asmus; Francesca Tuorto; Manfred Uhr; Florian Holsboer; Theo Rein; Jürgen Zschocke
Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(3):792-805.
2010: M Kimura; Peter Müller-Preuss; A Lu; E Wiesner; Cornelia Flachskamm; Wolfgang Wurst; Florian Holsboer; Jan M Deussing
Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep.
Molecular psychiatry 2010;15(2):154-65.
2010: Dietrich Trümbach; Cornelia Graf; Benno Pütz; Claudia Kühne; Markus Panhuysen; Peter Weber; Florian Holsboer; Wolfgang Wurst; Gerhard Welzl; Jan M Deussing
Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models.
BMC systems biology 2010;4():159.
2010: Amalia F Tsolakidou; Ludwig Czibere; Benno Pütz; Dietrich Trümbach; Markus Panhuysen; Jan M Deussing; Wolfgang Wurst; Inge Sillaber; Rainer Landgraf; Florian Holsboer; Theo Rein
Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein.
BMC genomics 2010;11():546.
2010: Marta Labeur; Florian Holsboer
Molecular mechanisms of glucocorticoid receptor signaling.
Medicina 2010;70(5):457-62.
2010: Shuang Yu; Alexandre V Patchev; Yan Wu; Jie Lu; Florian Holsboer; Jing-Zhong Zhang; Nuno Sousa; Osborne F X Almeida
Depletion of the neural precursor cell pool by glucocorticoids.
Annals of neurology 2010;67(1):21-30.
2010: Enrico Domenici; David R Willé; Federica Tozzi; Inga Prokopenko; Sam Miller; Astrid McKeown; Claire Brittain; Dan Rujescu; Ina Giegling; Christoph W Turck; Florian Holsboer; Edward T Bullmore; Lefkos Middleton; Emilio Merlo Pich; Robert Alexander; Pierandrea Muglia
Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections.
PloS one 2010;5(2):e9166.
2010: Petra Schüssler; Alexander Yassouridis; Manfred Uhr; Michael Kluge; Philipp Bleninger; Florian Holsboer; Axel Steiger
Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol.
Neuropsychobiology 2010;61(3):113-21.
2010: Susanne Lucae; Marcus Ising; Sonja Horstmann; Bernhard T Baune; Volker Arolt; Bertram Müller-Myhsok; Florian Holsboer; Katharina Domschke
HTR2A gene variation is involved in antidepressant treatment response.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010;20(1):65-8.
2010: Florian Holsboer; Marcus Ising
Stress hormone regulation: biological role and translation into therapy.
Annual review of psychology 2010;61():81-109, C1-11.
2009: Paul G Unschuld; Marcus Ising; Michael Specht; Erhardt Angelika; Stephan Ripke; Angela Heck; Stefan Kloiber; Verica Straub; Tanja Brueckl; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(8):1100-9.
2009: Petra Zimmermann; Tanja Brückl; Agnes Nocon; Hildegard Pfister; Roselind Lieb; Hans-Ulrich Wittchen; Florian Holsboer; Jules Angst
Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity.
Archives of general psychiatry 2009;66(12):1341-52.
2009: Chris Murgatroyd; Alexandre V Patchev; Yonghe Wu; Vincenzo Micale; Yvonne Bockmühl; Dieter Fischer; Florian Holsboer; Carsten T Wotjak; Osborne F X Almeida; Dietmar Spengler
Dynamic DNA methylation programs persistent adverse effects of early-life stress.
Nature neuroscience 2009;12(12):1559-66.
2009: Archana M Jastorff; Katrin Haegler; Giuseppina Maccarrone; Florian Holsboer; Frank Weber; Tjalf Ziemssen; Christoph W Turck
Regulation of proteins mediating neurodegeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.
Proteomics. Clinical applications 2009;3(11):1273-87.
2009: Damian Refojo; Florian Holsboer
CRH signaling. Molecular specificity for drug targeting in the CNS.
Annals of the New York Academy of Sciences 2009;1179():106-19.
2009: Rachel Yehuda; Guiqing Cai; Julia A Golier; Casey Sarapas; Sandro Galea; Marcus Ising; Theo Rein; James Schmeidler; Bertram Müller-Myhsok; Florian Holsboer; Joseph Buxbaum
Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.
Biological psychiatry 2009;66(7):708-11.
2009: Florian Holsboer
[Interview with professor Florian Holsboer (interview by Angelika Staub)].
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft für Sozialpädiatrie und Deutsche Gesellschaft für Kinderheilkunde 2009;28(9):380-1.
2009: Marcus Ising; Susanne Lucae; Elisabeth B Binder; Thomas Bettecken; Manfred Uhr; Stephan Ripke; Martin A Kohli; Johannes M Hennings; Sonja Horstmann; Stefan Kloiber; Andreas Menke; Brigitta Bondy; Rainer Rupprecht; Katharina Domschke; Bernhard T Baune; Volker Arolt; john rush; Florian Holsboer; Bertram Müller-Myhsok
A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.
Archives of general psychiatry 2009;66(9):966-75.
2009: Anja Siegmund; Maik Dahlhoff; Ursula Habersetzer; Anna Mederer; Eckhard Wolf; Florian Holsboer; Carsten T Wotjak
Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice.
Journal of psychiatric research 2009;43(14):1156-65.
2009: Ulrich S Zimmermann; Arlette F Buchmann; Constance Spring; Manfred Uhr; Florian Holsboer; Hans-Ulrich Wittchen
Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers.
Psychoneuroendocrinology 2009;34(7):996-1003.
2009: Rainer Rupprecht; Gerhard Rammes; Daniela Eser; Thomas C Baghai; Cornelius Schüle; Caroline Nothdurfter; Thomas Troxler; Conrad Gentsch; Hans O Kalkman; Frederique CHAPERON; Veska Uzunov; Kevin H McAllister; Valerie Bertaina-Anglade; Christophe Drieu La Rochelle; Dietrich Tuerck; Annette Floesser; Beate Kiese; Michael Schumacher; Rainer Landgraf; Florian Holsboer; Klaus Kucher
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.
Science (New York, N.Y.) 2009;325(5939):490-3.
2009: Becky Inkster; Thomas E Nichols; Philipp G Saemann; Dorothee P Auer; Florian Holsboer; Pierandrea Muglia; Paul Matthews
Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder.
Archives of general psychiatry 2009;66(7):721-8.
2009: A Heck; Roselind Lieb; A Ellgas; Hildegard Pfister; Susanne Lucae; D Roeske; Benno Pütz; Bertram Müller-Myhsok; Manfred Uhr; Florian Holsboer; Marcus Ising
Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking.
Genes, brain, and behavior 2009;8(4):464-72.
2009: Mathias V Schmidt; V Sterlemann; Klaus Wagner; Bertram Niederleitner; K Ganea; Claudia Liebl; Jan M Deussing; Stefan Berger; Günther Schütz; Florian Holsboer; Marianne B Müller
Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.
Endocrinology 2009;150(6):2709-16.
2009: Christoph K Thoeringer; S Ripke; Paul G Unschuld; Susanne Lucae; Marcus Ising; Thomas Bettecken; Manfred Uhr; Martin E Keck; B Mueller-Myhsok; Florian Holsboer; Elisabeth B Binder; Erhardt Angelika
The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(6):649-57.
2009: Anna Laenger; Isabelle Lang-Rollin; Christian Kozany; Jürgen Zschocke; Nicole Zimmermann; Joëlle Rüegg; Florian Holsboer; Felix Hausch; Theo Rein
XAP2 inhibits glucocorticoid receptor activity in mammalian cells.
FEBS letters 2009;583(9):1493-8.
2009: Ana C Liberman; Jimena Druker; Damian Refojo; Florian Holsboer; Eduardo Arzt
Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1558-71.
2009: Victoria B Risbrough; Mark A Geyer; Richard L Hauger; Sarah C Coste; Mary P Stenzel-Poore; Wolfgang Wurst; Florian Holsboer
CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1494-503.
2009: Stefanie Kalus; Thomas Kneib; Axel Steiger; Florian Holsboer; Alexander Yassouridis
A new strategy to analyze possible association structures between dynamic nocturnal hormone activities and sleep alterations in humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R1216-27.
2009: Heike E Künzel; Nibal Ackl; Martin Hatzinger; Katja Held; Edith Holsboer-Trachsler; Marcus Ising; Wolfgang Kaschka; Siegfried Kasper; Anastasios Konstantinidis; Annette Sonntag; Manfred Uhr; Alexander Yassouridis; Florian Holsboer; Axel Steiger
Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial.
Journal of psychiatric research 2009;43(7):702-10.
2009: Susana Silberstein; A M Vogl; Damian Refojo; S A Senin; Wolfgang Wurst; Florian Holsboer; Jan M Deussing; Eduardo Arzt
Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.
Neuroscience 2009;159(2):610-7.
2009: Florian Seemüller; Michael Riedel; Michael Obermeier; Michael Bauer; Mazda Adli; Christoph Mundt; Florian Holsboer; Peter Brieger; Gerd Laux; Wolfram Bender; Isabella Heuser; Joachim Zeiler; Wolfgang Gaebel; Markus Jäger; Verena Henkel; Hans-Jürgen Möller
The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(2):181-9.
2009: Susana Silberstein; Annette M Vogl; Juán José Bonfiglio; Wolfgang Wurst; Florian Holsboer; Eduardo Arzt; Jan M Deussing; Damian Refojo
Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models.
Annals of the New York Academy of Sciences 2009;1153():120-30.
2009: Ana C Liberman; Jimena Druker; Fernando Aprile Garcia; Florian Holsboer; Eduardo Arzt
Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions.
Annals of the New York Academy of Sciences 2009;1153():6-13.
2009: Sonja Horstmann; Tatjana Dose; Susanne Lucae; Stefan Kloiber; Andreas Menke; Johannes Hennings; Derek Spieler; Manfred Uhr; Florian Holsboer; Marcus Ising
Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action.
Psychoneuroendocrinology 2009;34(2):238-48.
2009: Anja Siegmund; Sebastian F Kaltwasser; Florian Holsboer; Michael Czisch; Carsten T Wotjak
Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice.
Biological psychiatry 2009;65(3):258-62.
2009: Angela Heck; Roselind Lieb; Andrea Ellgas; Hildegard Pfister; Susanne Lucae; Erhardt Angelika; Hubertus Himmerich; Sonja Horstmann; Stefan Kloiber; Stephan Ripke; Bertram Müller-Myhsok; Thomas Bettecken; Manfred Uhr; Florian Holsboer; Marcus Ising
Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(1):104-14.
2009: Michael Czisch; Renate Wehrle; Andrea Stiegler; Henning Peters; Katia Andrade; Florian Holsboer; Philipp G Sämann
Acoustic oddball during NREM sleep: a combined EEG/fMRI study.
PloS one 2009;4(8):e6749.
2009: Natalya Chechko; Renate Wehrle; Erhardt Angelika; Florian Holsboer; Michael Czisch; Philipp G Sämann
Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder.
PloS one 2009;4(5):e5537.
2009: Mirjam Bunck; Ludwig Czibere; Charlotte Horvath; Cornelia Graf; Elisabeth Frank; Melanie Keßler; Chris Murgatroyd; Bertram Müller-Myhsok; Mariya Gonik; Peter Weber; Benno Pütz; Patrik Muigg; Markus Panhuysen; Nicolas Singewald; Thomas Bettecken; Jan M Deussing; Florian Holsboer; Dietmar Spengler; Rainer Landgraf
A hypomorphic vasopressin allele prevents anxiety-related behavior.
PloS one 2009;4(4):e5129.
2009: Chadi Touma; Thomas Fenzl; Jörg Ruschel; Rupert Palme; Florian Holsboer; Mayumi Kimura; Rainer Landgraf
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression.
PloS one 2009;4(1):e4325.
2009: Johannes M Hennings; Toshimi Owashi; Elisabeth B Binder; Sonja Horstmann; Andreas Menke; Stefan Kloiber; Tatjana Dose; Bastian Wollweber; Derek Spieler; Thomas Messer; Rita Lutz; Heike E Künzel; Thomas Bierner; Thomas Pollmächer; Hildegard Pfister; Thomas Nickel; Annette Sonntag; Manfred Uhr; Marcus Ising; Florian Holsboer; Susanne Lucae
Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project.
Journal of psychiatric research 2009;43(3):215-29.
2009: Erhardt Angelika; M B Müller; A Rödel; Tobias Welt; frauke ohl; Florian Holsboer; M E Keck
Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775.
Journal of psychopharmacology (Oxford, England) 2009;23(1):31-9.
2008: Ulrike Schmidt; Florian Holsboer; Theo Rein
Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):E101; author reply E102.
2008: A Lu; Michel Steiner; N Whittle; A M Vogl; S M Walser; M Ableitner; Damian Refojo; M Ekker; J L Rubenstein; Günter K Stalla; Nicolas Singewald; Florian Holsboer; Carsten T Wotjak; Wolfgang Wurst; Jan M Deussing
Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system.
Molecular psychiatry 2008;13(11):989.
2008: Markus Wöhr; Maik Dahlhoff; Eckhard Wolf; Florian Holsboer; Rainer K W Schwarting; Carsten T Wotjak
Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study.
Behavior genetics 2008;38(6):579-95.
2008: Inge Sillaber; Markus Panhuysen; Markus S H Henniger; frauke ohl; Claudia Kühne; Benno Pütz; Thomas Pohl; Jan M Deussing; Marcelo Paez-Pereda; Florian Holsboer
Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine.
Psychopharmacology 2008;200(4):557-72.
2008: A Lu; Michel Steiner; N Whittle; A M Vogl; S M Walser; M Ableitner; Damian Refojo; M Ekker; J L Rubenstein; Günter K Stalla; Nicolas Singewald; Florian Holsboer; Carsten T Wotjak; Wolfgang Wurst; Jan M Deussing
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.
Molecular psychiatry 2008;13(11):1028-42.
2008: R Hanstein; A Lu; W Wurst; Florian Holsboer; J M Deussing; A B Clement; Christian Behl
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Neuroscience 2008;156(3):712-21.
2008: Martin E Keck; Nikola Kern; Erhardt Angelika; Paul G Unschuld; Marcus Ising; Daria Salyakina; Marianne B Müller; Carolin C Knorr; Roselind Lieb; Christa Hohoff; Petra Krakowitzky; Wolfgang Maier; Borwin Bandelow; Jürgen Fritze; Jürgen Deckert; Florian Holsboer; Bertram Müller-Myhsok; Elisabeth B Binder
Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(7):1196-204.
2008: Andreas Ströhle; Michael Scheel; Sieglinde Modell; Florian Holsboer
Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder.
Journal of psychiatric research 2008;42(14):1185-8.
2008: Elisabeth Friess; Dagmar Schmid; Sieglinde Modell; Hans Brunner; Christoph J Lauer; Florian Holsboer; Marcus Ising
Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders.
Journal of psychiatric research 2008;42(14):1154-62.
2008: Dagmar A Schmid; Hans Brunner; Christoph J Lauer; Manfred Uhr; Alexander Yassouridis; Florian Holsboer; Elisabeth Friess
Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression.
Journal of psychiatric research 2008;42(12):991-9.
2008: Helena C Kronsbein; Archana M Jastorff; Giuseppina Maccarrone; Günter K Stalla; Wolfgang Wurst; Florian Holsboer; Christoph W Turck; Jan M Deussing
CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells.
Molecular and cellular endocrinology 2008;292(1-2):1-10.
2008: S Reckow; P Gormanns; Florian Holsboer; C W Turck
Psychiatric disorders biomarker identification: from proteomics to systems biology.
Pharmacopsychiatry 2008;41 Suppl 1():S70-7.
2008: Hubertus Himmerich; Stephany Fulda; Jakob Linseisen; Henrike Seiler; Günther Wolfram; Stephanie Himmerich; Kurt Gedrich; Stefan Kloiber; Susanne Lucae; M Ising; Manfred Uhr; Florian Holsboer; Thomas Pollmächer
Depression, comorbidities and the TNF-alpha system.
European psychiatry : the journal of the Association of European Psychiatrists 2008;23(6):421-9.
2008: Urte Ambrosius; Sonja Lietzenmaier; Renate Wehrle; Adam Wichniak; Stefanie Kalus; Juliane Winkelmann; Thomas Bettecken; Florian Holsboer; Alexander Yassouridis; Elisabeth Friess
Heritability of sleep electroencephalogram.
Biological psychiatry 2008;64(4):344-8.
2008: Florian Holsboer
How can we realize the promise of personalized antidepressant medicines?
Nature reviews. Neuroscience 2008;9(8):638-46.
2008: Elisabeth Friess; Sieglinde Modell; Hans Brunner; Hirokuni Tagaya; Christoph J Lauer; Florian Holsboer; Marcus Ising
The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects.
European archives of psychiatry and clinical neuroscience 2008;258(5):285-91.
2008: Marcus Ising; Anna-Mareike Depping; Anna Siebertz; Susanne Lucae; Paul G Unschuld; Stefan Kloiber; Sonja Horstmann; Manfred Uhr; Bertram Müller-Myhsok; Florian Holsboer
Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.
The European journal of neuroscience 2008;28(2):389-98.
2008: Andreas Menke; Susanne Lucae; Stefan Kloiber; Sonja Horstmann; Thomas Bettecken; Manfred Uhr; Stephan Ripke; Marcus Ising; Bertram Müller-Myhsok; Florian Holsboer; Elisabeth B Binder
Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation.
The American journal of psychiatry 2008;165(7):917-8.
2008: Amalia F Tsolakidou; D Trümbach; Markus Panhuysen; Benno Pütz; Jan M Deussing; Wolfgang Wurst; Inge Sillaber; Florian Holsboer; Theo Rein
Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways.
Molecular and cellular neurosciences 2008;38(3):444-52.
2008: Chadi Touma; Mirjam Bunck; Lisa Glasl; Markus Nussbaumer; Rupert Palme; Hendrik Stein; Michael Wolferstätter; Ramona Zeh; Marina Zimbelmann; Florian Holsboer; Rainer Landgraf
Mice selected for high versus low stress reactivity: a new animal model for affective disorders.
Psychoneuroendocrinology 2008;33(6):839-62.
2008: Michel Steiner; K Wanisch; Krisztina Monory; Giovanni Marsicano; E Borroni; H Bächli; Florian Holsboer; Beat Lutz; Carsten T Wotjak
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.
The pharmacogenomics journal 2008;8(3):196-208.
2008: Florian Holsboer; Marcus Ising
Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists.
European journal of pharmacology 2008;583(2-3):350-7.
2008: Erhardt Angelika; Susanne Lucae; Nikola Kern; Paul G Unschuld; Marcus Ising; Roselind Lieb; Manfred Uhr; Carsten Hohoff; Jürgen Deckert; B Bandelow; Wolfgang Maier; Elisabeth B Binder; Bertram Müller-Myhsok; Martin E Keck; Florian Holsboer
Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks.
Molecular psychiatry 2008;13(3):242-3.
2008: Juliane Winkelmann; Peter Lichtner; Barbara Schormair; Manfred Uhr; Stephanie Hauk; Karin Stiasny-Kolster; Claudia Trenkwalder; Walter Paulus; Ines Peglau; Ilonka Eisensehr; Thomas Illig; H-Erich Wichmann; Hildegard Pfister; Jelena Golic; Thomas Bettecken; Benno Pütz; Florian Holsboer; Thomas Meitinger; Bertram Müller-Myhsok
Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome.
Movement disorders : official journal of the Movement Disorder Society 2008;23(3):350-8.
2008: V Sterlemann; K Ganea; Claudia Liebl; Daniela Harbich; Stephanie Alam; Florian Holsboer; Marianne B Müller; Mathias V Schmidt
Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders.
Hormones and behavior 2008;53(2):386-94.
2008: Shuang Yu; Florian Holsboer; Osborne Almeida
Neuronal actions of glucocorticoids: focus on depression.
The Journal of steroid biochemistry and molecular biology 2008;108(3-5):300-9.
2008: Manfred Uhr; Alina Tontsch; Christian Namendorf; Stephan Ripke; Susanne Lucae; Marcus Ising; Tatjana Dose; Martin Ebinger; Marcus C Rosenhagen; Martin Kohli; Stefan Kloiber; Daria Salyakina; Thomas Bettecken; Michael Specht; Benno Pütz; Elisabeth B Binder; Bertram Müller-Myhsok; Florian Holsboer
Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression.
Neuron 2008;57(2):203-9.
2008: Michel Steiner; Giovanni Marsicano; Eric J Nestler; Florian Holsboer; Beat Lutz; Carsten T Wotjak
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
Psychoneuroendocrinology 2008;33(1):54-67.
2008: Paul G Unschuld; Marcus Ising; Erhardt Angelika; Susanne Lucae; Martin Kohli; Stefan Kloiber; Daria Salyakina; Christoph K Thoeringer; Nikola Kern; Roselind Lieb; Manfred Uhr; Elisabeth B Binder; Bertram Müller-Myhsok; Florian Holsboer; Martin E Keck
Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder.
Journal of affective disorders 2008;105(1-3):177-84.
2007: Marcus Ising; Florian Holsboer
CRH-sub-1 receptor antagonists for the treatment of depression and anxiety.
Experimental and clinical psychopharmacology 2007;15(6):519-28.
2007: Melanie Keßler; Chris Murgatroyd; Mirjam Bunck; Ludwig Czibere; Elisabeth Frank; Wolfgang Jacob; Charlotte Horvath; Patrik Muigg; Florian Holsboer; Nicolas Singewald; Dietmar Spengler; Rainer Landgraf
Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.
The European journal of neuroscience 2007;26(10):2857-64.
2007: Alberto Carbia Nagashima; Juan Gerez; Carolina Perez-Castro; Marcelo Paez-Pereda; Susana Silberstein; Günter K Stalla; Florian Holsboer; Eduardo Arzt
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
Cell 2007;131(2):309-23.
2007: Christoph K Thoeringer; Elisabeth B Binder; Daria Salyakina; Erhardt Angelika; Marcus Ising; Paul G Unschuld; Nikola Kern; Susanne Lucae; Tanja M Brueckl; Marianne B Mueller; Brigitte Fuchs; Benno Pütz; Roselind Lieb; Manfred Uhr; Florian Holsboer; Bertram Mueller-Myhsok; Martin E Keck
Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks.
Journal of psychiatric research 2007;41(7):579-84.
2007: Marcus Ising; Ulrich Zimmermann; Heike E Künzel; Manfred Uhr; Alan C Foster; Susan M Learned-Coughlin; Florian Holsboer; Dimitri E Grigoriadis
High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(9):1941-9.
2007: Simone Reppermund; Josef Zihl; Susanne Lucae; Sonja Horstmann; Stefan Kloiber; Florian Holsboer; Marcus Ising
Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation.
Biological psychiatry 2007;62(5):400-6.
2007: Stefan Kloiber; Marcus Ising; Simone Reppermund; Sonja Horstmann; Tatjana Dose; Matthias Majer; Josef Zihl; Hildegard Pfister; Paul G Unschuld; Florian Holsboer; Susanne Lucae
Overweight and obesity affect treatment response in major depression.
Biological psychiatry 2007;62(4):321-6.
2007: Juliane Winkelmann; Barbara Schormair; Peter Lichtner; Stephan Ripke; Lan Xiong; Shapour Jalilzadeh; Stephany Fulda; Benno Pütz; Gertrud Eckstein; Stephanie Hauk; Claudia Trenkwalder; Alexander Zimprich; Karin Stiasny-Kolster; Wolfgang H Oertel; Cornelius G Bachmann; Walter Paulus; Ines Peglau; Ilonka Eisensehr; Jacques Montplaisir; Gustavo Turecki; Guy Rouleau; Christian Gieger; Thomas Illig; H-Erich Wichmann; Florian Holsboer; Bertram Müller-Myhsok; Thomas Meitinger
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
Nature genetics 2007;39(8):1000-6.
2007: Jan M Deussing; Claudia Kühne; Benno Pütz; Markus Panhuysen; Johannes Breu; Mary P Stenzel-Poore; Florian Holsboer; Wolfgang Wurst
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(8):1476-95.
2007: Erhardt Angelika; Susanne Lucae; Paul G Unschuld; Marcus Ising; Nikola Kern; Daria Salyakina; Roselind Lieb; Manfred Uhr; Elisabeth B Binder; Martin E Keck; Bertram Müller-Myhsok; Florian Holsboer
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
Journal of affective disorders 2007;101(1-3):159-68.
2007: Christoph K Thoeringer; Inge Sillaber; Angelika Roedel; Erhardt Angelika; Marianne B Mueller; frauke ohl; Florian Holsboer; Martin E Keck
The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice.
Psychoneuroendocrinology 2007;32(6):746-57.
2007: Marcus Ising; Sonja Horstmann; Stefan Kloiber; Susanne Lucae; Elisabeth B Binder; Nikola Kern; Heike E Künzel; Andrea Pfennig; Manfred Uhr; Florian Holsboer
Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
Biological psychiatry 2007;62(1):47-54.
2007: Paul G Unschuld; Marcus Ising; Erhardt Angelika; Susanne Lucae; Stefan Kloiber; Martin Kohli; Daria Salyakina; Tobias Welt; Nikola Kern; Roselind Lieb; Manfred Uhr; Elisabeth B Binder; Bertram Müller-Myhsok; Florian Holsboer; Martin E Keck
Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(4):424-9.
2007: Mathias V Schmidt; V Sterlemann; K Ganea; C Liebl; S Alam; D Harbich; M Greetfeld; Manfred Uhr; Florian Holsboer; Marianne B Müller
Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence.
Psychoneuroendocrinology 2007;32(5):417-29.
2007: Ana C Liberman; Damian Refojo; Jimena Druker; Marta Toscano; Theo Rein; Florian Holsboer; Eduardo Arzt
The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1177-88.
2007: Helmut Vedder; Wolfgang Schreiber; Andreas Schuld; Martin Kainz; Christoph J Lauer; Jürgen-Christian Krieg; Florian Holsboer; Thomas Pollmächer
Immune-endocrine host response to endotoxin in major depression.
Journal of psychiatric research 2007;41(3-4):280-9.
2007: Renate Wehrle; Christian Kaufmann; Thomas C Wetter; Florian Holsboer; Dorothee P Auer; Thomas Pollmächer; Michael Czisch
Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods.
The European journal of neuroscience 2007;25(3):863-71.
2007: Florian Then Bergh; Tania Kümpfel; Alexander Yassouridis; Christian Lechner; Florian Holsboer; Claudia Trenkwalder
Acute and chronic neuroendocrine effects of interferon-beta 1a in multiple sclerosis.
Clinical endocrinology 2007;66(2):295-303.
2007: Rudolph Marsch; Elisabeth Foeller; Gerhard Rammes; Mirjam Bunck; Manfred Kössl; Florian Holsboer; Walter Zieglgänsberger; Rainer Landgraf; Beat Lutz; Carsten T Wotjak
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):832-9.
2007: Hubertus Himmerich; Petra Zimmermann; Marcus Ising; Stefan Kloiber; Susanne Lucae; Heike E Kunzel; Elisabeth B Binder; Florian Holsboer; Manfred Uhr
Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment.
Neuropsychobiology 2007;55(1):28-35.
2006: Tobias Welt; Mario Engelmann; Ulrich Renner; Erhardt Angelika; Marianne B Müller; Rainer Landgraf; Florian Holsboer; Martin E Keck
Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2573-9.
2006: Jimena Druker; Ana C Liberman; Matías Acuña; Damiana Giacomini; Damian Refojo; Susana Silberstein; Marcelo Paez Pereda; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases.
Annals of the New York Academy of Sciences 2006;1088():297-306.
2006: Giuseppina Maccarrone; Nikolaus Kolb; Larysa Teplytska; Isabel Birg; Richard Zollinger; Florian Holsboer; Christoph W Turck
Phosphopeptide enrichment by IEF.
Electrophoresis 2006;27(22):4585-95.
2006: Mathias V Schmidt; Seymour Levine; S Alam; D Harbich; V Sterlemann; K Ganea; Ron de Kloet; Florian Holsboer; Marianne B Müller
Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse.
Journal of neuroendocrinology 2006;18(11):865-74.
2006: Thomas C Baghai; Elisabeth B Binder; Cornelius Schule; Daria Salyakina; Daniela Eser; Susanne Lucae; Peter Zwanzger; C Haberger; Peter Zill; Marcus Ising; Tobias Deiml; Manfred Uhr; T Illig; H-E Wichmann; Sieglinde Modell; Caroline Nothdurfter; Florian Holsboer; Bertram Müller-Myhsok; Hans-Jürgen Möller; Rainer Rupprecht; Brigitta Bondy
Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism.
Molecular psychiatry 2006;11(11):1003-15.
2006: Erhardt Angelika; Marcus Ising; Paul G Unschuld; Nikola Kern; Susanne Lucae; Benno Pütz; Manfred Uhr; Elisabeth B Binder; Florian Holsboer; Martin E Keck
Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(11):2515-22.
2006: Hubertus Himmerich; Elisabeth B Binder; Heike E Künzel; Andreas Schuld; Susanne Lucae; Manfred Uhr; Thomas Pollmächer; Florian Holsboer; Marcus Ising
Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis.
Biological psychiatry 2006;60(8):882-8.
2006: Mathias V Schmidt; Jan M Deussing; Melly S Oitzl; frauke ohl; Seymour Levine; Wolfgang Wurst; Florian Holsboer; Marianne B Müller; Ron de Kloet
Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice.
The European journal of neuroscience 2006;24(8):2291-8.
2006: Angelika Roedel; Corinna Storch; Florian Holsboer; frauke ohl
Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice.
Laboratory animals 2006;40(4):371-81.
2006: Ngoc Khoi Nguyen; Martin E Keck; Alfred Hetzenauer; Christoph K Thoeringer; Wolfgang Wurst; Jan M Deussing; Florian Holsboer; Marianne B Müller; Nicolas Singewald
Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge.
Psychopharmacology 2006;188(3):374-85.
2006: Eduardo Arzt; Florian Holsboer
CRF signaling: molecular specificity for drug targeting in the CNS.
Trends in pharmacological sciences 2006;27(10):531-8.
2006: Claudia Ditzen; Archana M Jastorff; Melanie Keßler; Mirjam Bunck; Larysa Teplytska; Erhardt Angelika; Simone A Krömer; Jeeva Varadarajulu; Bianca-Sabrina Targosz; Eser F Sayan-Ayata; Florian Holsboer; Rainer Landgraf; Christoph W Turck
Protein biomarkers in a mouse model of extremes in trait anxiety.
Molecular & cellular proteomics : MCP 2006;5(10):1914-20.
2006: Elisabeth Friess; Tania Kuempfel; Sieglinde Modell; Juliane Winkelmann; Florian Holsboer; Marcus Ising; Claudia Trenkwalder
Paroxetine treatment improves motor symptoms in patients with multiple system atrophy.
Parkinsonism & related disorders 2006;12(7):432-7.
2006: Petra Schüssler; Alexander Yassouridis; Manfred Uhr; Michael Kluge; Jutta C Weikel; Florian Holsboer; Axel Steiger
Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E549-56.
2006: Victor Castillo; Damiana Giacomini; Marcelo Páez-Pereda; Johanna Stalla; Marta Labeur; Marily Theodoropoulou; Florian Holsboer; Ashley B Grossman; Günter K Stalla; Eduardo Arzt
Retinoic acid as a novel medical therapy for Cushing's disease in dogs.
Endocrinology 2006;147(9):4438-44.
2006: Susanne Lucae; Daria Salyakina; Nicholas Barden; Mario Harvey; Bernard Gagné; Michel Labbé; Elisabeth B Binder; Manfred Uhr; Marcelo Paez-Pereda; Inge Sillaber; Marcus Ising; Tanja Brückl; Roselind Lieb; Florian Holsboer; Bertram Müller-Myhsok
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.
Human molecular genetics 2006;15(16):2438-45.
2006: Marianne B Müller; Florian Holsboer
Mice with mutations in the HPA-system as models for symptoms of depression.
Biological psychiatry 2006;59(12):1104-15.
2006: Nicholas Barden; Mario Harvey; Bernard Gagné; Eric Shink; Monique Tremblay; Catherine Raymond; Michel Labbé; André Villeneuve; Denis Rochette; Lise Bordeleau; Herbert Stadler; Florian Holsboer; Bertram Müller-Myhsok
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(4):374-82.
2006: Andreas Schuld; S Birkmann; Pierre A Beitinger; Monika Haack; Thomas Kraus; Mira A Dalal; Florian Holsboer; Thomas Pollmächer
Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2006;114(6):322-8.
2006: Anke Post; Nibal Ackl; Monika Rücker; Yvonne A Schreiber; Elisabeth B Binder; Marcus Ising; Annette Sonntag; Florian Holsboer; Osborne Almeida
Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression.
Biological psychiatry 2006;59(9):858-62.
2006: Elisabeth F C van Rossum; Elisabeth B Binder; Matthias Majer; Jan W Koper; Marcus Ising; Sieglinde Modell; Daria Salyakina; Steven W J Lamberts; Florian Holsboer
Polymorphisms of the glucocorticoid receptor gene and major depression.
Biological psychiatry 2006;59(8):681-8.
2006: Christian Kaufmann; Renate Wehrle; Thomas C Wetter; Florian Holsboer; Dorothee P Auer; Thomas Pollmächer; Michael Czisch
Brain activation and hypothalamic functional connectivity during human non-rapid eye movement sleep: an EEG/fMRI study.
Brain : a journal of neurology 2006;129(Pt 3):655-67.
2006: Marcus Ising; Florian Holsboer
Genetics of stress response and stress-related disorders.
Dialogues in clinical neuroscience 2006;8(4):433-44.
2006: Florian Then Bergh; Tania Kümpfel; Erina M Schumann; Ulrike Held; Michaela Schwan; Mirjana Blazevic; Axel Wismüller; Florian Holsboer; Alexander Yassouridis; Manfred Uhr; Frank Weber; Martin Daumer; Claudia Trenkwalder; Dorothee P Auer
Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations.
BMC neurology 2006;6():19.
2006: Elisabeth B Binder; Florian Holsboer
Pharmacogenomics and antidepressant drugs.
Annals of medicine 2006;38(2):82-94.
2005: Jürgen Brunner; Thomas Bronisch; Manfred Uhr; Marcus Ising; Elisabeth Binder; Florian Holsboer; Christoph W Turck
Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters.
European archives of psychiatry and clinical neuroscience 2005;255(6):438-40.
2005: Florian Holsboer
Unipolar versus bipolar disorder: a distinction not helpful for studies of causality.
Current psychiatry reports 2005;7(6):405-7.
2005: Brigitte Eisensamer; Manfred Uhr; Sabrina Meyr; Gerald Gimpl; Tobias Deiml; Gerhard Rammes; Jeremy J Lambert; Walter Zieglgänsberger; Florian Holsboer; Rainer Rupprecht
Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(44):10198-206.
2005: Sieglinde Modell; Marcus Ising; Florian Holsboer; Christoph J Lauer
The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands.
Biological psychiatry 2005;58(9):694-9.
2005: Marcelo Paez-Pereda; Damiana Giacomini; Carlos Echenique; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(3):259-67.
2005: Johannes Schumacher; Rami Abou Jamra; Tim Becker; Stephanie Ohlraun; Norman Klopp; Elisabeth B Binder; Thomas G. Schulze; Monika Deschner; Christine Schmäl; Susanne Höfels; Astrid Zobel; Thomas Illig; Peter Propping; Florian Holsboer; Marcella Rietschel; Markus M Nöthen; Sven Cichon
Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.
Biological psychiatry 2005;58(4):307-14.
2005: Christophe Crochemore; J Lu; Y Wu; Z Liposits; Nuno Sousa; Florian Holsboer; Osborne Almeida
Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation.
Molecular psychiatry 2005;10(8):790-8.
2005: Florian Holsboer
The future of antidepressant pharmacogenetics is arriving. Introduction.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(6):996-8.
2005: Marcus Ising; Heike E Künzel; Elisabeth B Binder; Thomas Nickel; Sieglinde Modell; Florian Holsboer
The combined dexamethasone/CRH test as a potential surrogate marker in depression.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(6):1085-93.
2005: Ron de Kloet; Marian Joëls; Florian Holsboer
Stress and the brain: from adaptation to disease.
Nature reviews. Neuroscience 2005;6(6):463-75.
2005: Anke Post; frauke ohl; Osborne Almeida; Elisabeth B Binder; Monika Rücker; Sandra Welt; Elisabeth B Binder; Florian Holsboer; Inge Sillaber
Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919).
Psychopharmacology 2005;180(1):150-8.
2005: Renate Wehrle; Michael Czisch; Christian Kaufmann; Thomas C Wetter; Florian Holsboer; Dorothee P Auer; Thomas Pollmächer
Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study.
Neuroreport 2005;16(8):853-7.
2005: Simone A Krömer; Melanie Keßler; Dale Milfay; Isabel Birg; Mirjam Bunck; Ludwig Czibere; Markus Panhuysen; Benno Pütz; Jan M Deussing; Florian Holsboer; Rainer Landgraf; Christoph W Turck
Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4375-84.
2005: Damian Refojo; Carlos Echenique; Marianne B Müller; Johannes M H M Reul; Jan M Deussing; Wolfgang Wurst; Inge Sillaber; Marcelo Paez-Pereda; Florian Holsboer; Eduardo Arzt
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6183-8.
2005: Martin E Keck; Simone B Sartori; Tobias Welt; Marianne B Müller; frauke ohl; Florian Holsboer; Rainer Landgraf; Nicolas Singewald
Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment.
Journal of neurochemistry 2005;92(5):1170-9.
2005: Mathias V Schmidt; M Schmidt; Seymour Levine; Melly S Oitzl; Maaike H van der Mark; Marianne B Müller; Florian Holsboer; Ron de Kloet
Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse.
Endocrinology 2005;146(3):1458-64.
2005: Heike E Künzel; Marcus Ising; Astrid Zobel; Thomas Nickel; Nibal Ackl; Annette Sonntag; Florian Holsboer; Manfred Uhr
Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression.
Journal of psychiatric research 2005;39(2):173-7.
2005: Andrea Pfennig; Heike E Kunzel; Nikola Kern; Marcus Ising; Matthias Majer; Brigitte Fuchs; Gertrud Ernst; Florian Holsboer; Elisabeth B Binder
Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression.
Biological psychiatry 2005;57(4):336-42.
2005: Gabriela M Wochnik; Joëlle Rüegg; G Alexander Abel; Ulrike Schmidt; Florian Holsboer; Theo Rein
FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.
The Journal of biological chemistry 2005;280(6):4609-16.
2005: Michaela Gottschalk; Tania Kümpfel; Peter Flachenecker; Manfred Uhr; Claudia Trenkwalder; Florian Holsboer; Frank Weber
Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.
Archives of neurology 2005;62(2):277-80.
2005: Greisa Vila; Maria Papazoglou; Johanna Stalla; Marily Theodoropoulou; Günter K Stalla; Florian Holsboer; Marcelo Paez-Pereda
Sonic hedgehog regulates CRH signal transduction in the adult pituitary.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):281-3.
2005: Martin E Keck; frauke ohl; Florian Holsboer; Marianne B Müller
Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders.
Neuroscience and biobehavioral reviews 2005;29(4-5):867-89.
2005: Maria Tichomirowa; M E Keck; Harald Jörn Schneider; Marcelo Paez-Pereda; Ulrich Renner; Florian Holsboer; Günter K Stalla
Endocrine disturbances in depression.
Journal of endocrinological investigation 2005;28(1):89-99.
2005: Juliane Winkelmann; M Prager; Roselind Lieb; Hildegard Pfister; B Spiegel; Hans-Ulrich Wittchen; Florian Holsboer; Claudia Trenkwalder; Andreas Ströhle
"Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome.
Journal of neurology 2005;252(1):67-71.
2005: Marcus Ising; Christoph J Lauer; Florian Holsboer; Sieglinde Modell
The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands.
Journal of psychiatric research 2005;39(1):21-8.
2004: Matthias Majer; Marcus Ising; Heike E Künzel; Elisabeth B Binder; Florian Holsboer; Sieglinde Modell; Josef Zihl
Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders.
Psychological medicine 2004;34(8):1453-63.
2004: Joëlle Rüegg; Florian Holsboer; Christoph Turck; Theo Rein
Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells.
Molecular and cellular biology 2004;24(21):9371-82.
2004: Harald Murck; Katja Held; Marc Ziegenbein; Heike E Künzel; Florian Holsboer; Axel Steiger
Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG.
Psychoneuroendocrinology 2004;29(9):1205-11.
2004: Adam Wichniak; Hans Brunner; Marcus Ising; Francisco Pedrosa Gil; Florian Holsboer; Elisabeth Friess
Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression.
Psychoneuroendocrinology 2004;29(9):1101-8.
2004: Chris Murgatroyd; Alexandra Wigger; Elisabeth Frank; Nicolas Singewald; Mirjam Bunck; Florian Holsboer; Rainer Landgraf; Dietmar Spengler
Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(35):7762-70.
2004: Raffael Kalisch; Nicolas Salomé; Stefan Platzer; Alexandra Wigger; Michael Czisch; Wolfgang Sommer; Nicolas Singewald; Markus Heilig; Achim Berthele; Florian Holsboer; Rainer Landgraf; Dorothee P Auer
High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats.
NeuroImage 2004;23(1):382-91.
2004: Gerhard Rammes; Brigitte Eisensamer; U Ferrari; M Shapa; Gerald Gimpl; K Gilling; C Parsons; K Riering; Gerhard Hapfelmeier; B Bondy; Walter Zieglgänsberger; Florian Holsboer; Rainer Rupprecht
Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner.
Molecular psychiatry 2004;9(9):846-58, 818.
2004: Heide Oertel; Harald Jörn Schneider; Günter K Stalla; Florian Holsboer; Josef Zihl
The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism.
Psychoneuroendocrinology 2004;29(7):839-50.
2004: Giuseppina Maccarrone; Dale Milfay; Isabel Birg; Marcus C Rosenhagen; Florian Holsboer; Rudolf Grimm; Jerome Bailey; Nina Zolotarjova; Christoph W Turck
Mining the human cerebrospinal fluid proteome by immunodepletion and shotgun mass spectrometry.
Electrophoresis 2004;25(14):2402-12.
2004: Michael Czisch; Renate Wehrle; Christian Kaufmann; Thomas C Wetter; Florian Holsboer; Thomas Pollmächer; Dorothee P Auer
Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates.
The European journal of neuroscience 2004;20(2):566-74.
2004: Ulrich Zimmermann; Konstanze Spring; Hans-Ulrich Wittchen; Hubertus Himmerich; Rainer Landgraf; Manfred Uhr; Florian Holsboer
Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers.
Journal of psychiatric research 2004;38(4):385-93.
2004: Martin E Keck; Florian Holsboer; Marianne B Müller
Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders.
Annals of the New York Academy of Sciences 2004;1018():445-57.
2004: Christoph J Lauer; Sieglinde Modell; Wolfgang Schreiber; Jürgen-Christian Krieg; Florian Holsboer
Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86.
Journal of clinical psychopharmacology 2004;24(3):356-7.
2004: Ulrich Zimmermann; Konstanze Spring; Sabine Ruth Kunz-Ebrecht; Manfred Uhr; Hans-Ulrich Wittchen; Florian Holsboer
Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(6):1156-65.
2004: U Zimmerman; K Spring; G Koller; Florian Holsboer; M Soyka
Hypothalamic-pituitary-adrenal system regulation in recently detoxified alcoholics is not altered by one week of treatment with acamprosate.
Pharmacopsychiatry 2004;37(3):98-102.
2004: Damian Kovalovsky; Marcelo Paez-Pereda; Marta Labeur; Ulrich Renner; Florian Holsboer; Günter K Stalla; Eduardo Arzt
Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs.
FEBS letters 2004;563(1-3):229-33.
2004: Ulrich Zimmermann; Konstanze Spring; Hans-Ulrich Wittchen; Florian Holsboer
Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers.
Alcoholism, clinical and experimental research 2004;28(3):424-32.
2004: Katja Held; Heike E Künzel; Marcus Ising; Dagmar A Schmid; Astrid Zobel; Harald Murck; Florian Holsboer; Axel Steiger
Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression.
Journal of psychiatric research 2004;38(2):129-36.
2004: Elisabeth Friess; Hirokuni Tagaya; Claus Grethe; Lorenz Trachsel; Florian Holsboer
Acute cortisol administration promotes sleep intensity in man.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(3):598-604.
2004: Gabriela M Wochnik; Jason C Young; Ulrike Schmidt; Florian Holsboer; F Ulrich Hartl; Theo Rein
Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.
FEBS letters 2004;560(1-3):35-8.
2004: Corinna Storch; Arnold Höhne; Florian Holsboer; frauke ohl
Activity patterns as a correlate for sleep-wake behaviour in mice.
Journal of neuroscience methods 2004;133(1-2):173-9.
2004: Marianne B Müller; Manfred Uhr; Florian Holsboer; Martin E Keck
Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice.
Neuroendocrinology 2004;79(1):1-12.
2004: Martin E Keck; Marianne B Müller; Elisabeth B Binder; Annette Sonntag; Florian Holsboer
Ziprasidone-related tardive dyskinesia.
The American journal of psychiatry 2004;161(1):175-6.
2004: Alexandra Wigger; Mar M Sánchez; Kenneth C Mathys; Karl Ebner; Elisabeth Frank; Dong Liu; Adelheid E Kresse; Inga D Neumann; Florian Holsboer; Paul M Plotsky; Rainer Landgraf
Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):1-14.
2003: Florian Holsboer
High-quality antidepressant discovery by understanding stress hormone physiology.
Annals of the New York Academy of Sciences 2003;1007():394-404.
2003: Heike E Künzel; Elisabeth B Binder; Thomas Nickel; Marcus Ising; Brigitte Fuchs; Matthias Majer; Andrea Pfennig; G Ernst; Nikola Kern; Dagmar A Schmid; Manfred Uhr; Florian Holsboer; Sieglinde Modell
Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2169-78.
2003: Akihiko Oshima; Cornelia Flachskamm; Johannes M H M Reul; Florian Holsboer; Astrid C E Linthorst
Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2148-59.
2003: Brigitte Eisensamer; Gerhard Rammes; Gerald Gimpl; M Shapa; U Ferrari; Gerhard Hapfelmeier; B Bondy; C Parsons; K Gilling; Walter Zieglgänsberger; Florian Holsboer; Rainer Rupprecht
Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor.
Molecular psychiatry 2003;8(12):994-1007.
2003: Heike E Künzel; Astrid Zobel; Thomas Nickel; Nibal Ackl; Manfred Uhr; Annette Sonntag; Marcus Ising; Florian Holsboer
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.
Journal of psychiatric research 2003;37(6):525-33.
2003: Andreas Schuld; Dagmar A Schmid; Monika Haack; Florian Holsboer; Elisabeth Friess; Thomas Pollmächer
Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone.
Journal of psychiatric research 2003;37(6):463-70.
2003: Marianne B Müller; Martin E Keck; Elisabeth B Binder; Adelheid E Kresse; Thomas P Hagemeyer; Rainer Landgraf; Florian Holsboer; Manfred Uhr
ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1991-9.
2003: Manfred Uhr; Markus T Grauer; Florian Holsboer
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption.
Biological psychiatry 2003;54(8):840-6.
2003: Marianne B Müller; Stephan Zimmermann; Inge Sillaber; Thomas P Hagemeyer; Jan M Deussing; Peter Timpl; Michael S D Kormann; Susanne K Droste; Ralf Kühn; Johannes M H M Reul; Florian Holsboer; Wolfgang Wurst
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Nature neuroscience 2003;6(10):1100-7.
2003: Marcus C Rosenhagen; Csaba Söti; Ulrike Schmidt; Gabriela M Wochnik; F Ulrich Hartl; Florian Holsboer; Jason C Young; Theo Rein
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):1991-2001.
2003: Alexandra S Herr; Amalia F Tsolakidou; Alexander Yassouridis; Florian Holsboer; Theo Rein
Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro.
Neuroendocrinology 2003;78(1):12-22.
2003: Marcel M van Gaalen; Mary P Stenzel-Poore; Florian Holsboer; Thomas Steckler
Reduced attention in mice overproducing corticotropin-releasing hormone.
Behavioural brain research 2003;142(1-2):69-79.
2003: Cornelius G Bachmann; Astrid C E Linthorst; Florian Holsboer; Johannes M H M Reul
Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1056-67.
2003: Damian Refojo; Ana C Liberman; Damiana Giacomini; Alberto Carbia Nagashima; Mariana Graciarena; Carlos Echenique; Marcelo Paez-Pereda; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells.
Annals of the New York Academy of Sciences 2003;992():196-204.
2003: Rosana G Peñalva; Marike Lancel; Cornelia Flachskamm; Johannes M H M Reul; Florian Holsboer; Astrid C E Linthorst
Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats.
The European journal of neuroscience 2003;17(9):1896-906.
2003: Sieglinde Modell; Johannes Huber; Florian Holsboer; Christoph J Lauer
The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolarity.
Journal of affective disorders 2003;74(2):173-84.
2003: Thomas Nickel; Annette Sonntag; Julia Schill; Astrid Zobel; Nibal Ackl; Alexander Brunnauer; Harald Murck; Marcus Ising; Alexander Yassouridis; Axel Steiger; Josef Zihl; Florian Holsboer
Clinical and neurobiological effects of tianeptine and paroxetine in major depression.
Journal of clinical psychopharmacology 2003;23(2):155-68.
2003: Ulrike Schmidt; Gabriela M Wochnik; Marcus C Rosenhagen; Jason C Young; F Ulrich Hartl; Florian Holsboer; Theo Rein
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor.
The Journal of biological chemistry 2003;278(7):4926-31.
2003: Marcelo Paez-Pereda; Damiana Giacomini; Damian Refojo; Alberto Carbia Nagashima; Ursula Hopfner; Yvonne Grubler; Alberto Chervin; Victoria Goldberg; Rodolfo Goya; Shane T Hentges; Malcolm J Low; Florian Holsboer; Günter K Stalla; Eduardo Arzt
Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1034-9.
2003: Harald Murck; Thomas Nickel; Heike E Künzel; Irina A Antonijevic; Julia Schill; Astrid Zobel; Axel Steiger; Annette Sonntag; Florian Holsboer
State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):348-58.
2003: Martin E Keck; Tobias Welt; Marianne B Müller; Manfred Uhr; frauke ohl; Alexandra Wigger; Nicola Toschi; Florian Holsboer; Rainer Landgraf
Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):235-43.
2003: Andreas Ströhle; Elena Romeo; Flavia di Michele; Augusto Pasini; Bettina Hermann; Gisela Gajewsky; Florian Holsboer; Rainer Rupprecht
Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results.
Archives of general psychiatry 2003;60(2):161-8.
2003: Anke Hoffmann; Elisabetta Ciani; Joel Boeckardt; Florian Holsboer; Laurent Journot; Dietmar Spengler
Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.
Molecular and cellular biology 2003;23(3):988-1003.
2003: Yuri A Mitev; MH Darwish; Siegmund S Wolf; Florian Holsboer; Osborne Almeida; Vladimir Patchev
Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection.
Neuroscience 2003;120(2):541-9.
2003: Mathias V Schmidt; M Schmidt; Melly S Oitzl; Marianne B Müller; frauke ohl; Wolfgang Wurst; Florian Holsboer; Seymour Levine; Ron de Kloet
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice.
Neuroscience 2003;119(2):589-95.
2003: Martin E Keck; Tobias Welt; Marianne B Müller; Rainer Landgraf; Florian Holsboer
The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats.
Pharmacopsychiatry 2003;36(1):27-31.
2003: Florian Holsboer
Corticotropin-releasing hormone modulators and depression.
Current opinion in investigational drugs (London, England : 2000) 2003;4(1):46-50.
2003: frauke ohl; Angelika Roedel; Elisabeth B Binder; Florian Holsboer
Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice.
The European journal of neuroscience 2003;17(1):128-36.
2003: Ulrich Zimmermann; Wolfgang Hundt; Konstanze Spring; Andreas Grabner; Florian Holsboer
Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism.
Biological psychiatry 2003;53(1):75-84.
2002: Astrid C E Linthorst; Rosana G Peñalva; Cornelia Flachskamm; Florian Holsboer; Johannes M H M Reul
Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism.
The European journal of neuroscience 2002;16(12):2441-52.
2002: Damian Refojo; Damian Kovalovsky; Juan I Young; Marcelo Rubinstein; Florian Holsboer; Johannes M H M Reul; Malcolm J Low; Eduardo Arzt
Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice.
Journal of neuroimmunology 2002;131(1-2):126-34.
2002: Sieglinde Modell; Marcus Ising; Florian Holsboer; Christoph J Lauer
The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time.
Biological psychiatry 2002;52(5):430-7.
2002: M Uhr; Florian Holsboer; Marianne B Müller
Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins.
Journal of neuroendocrinology 2002;14(9):753-9.
2002: Marcel M van Gaalen; J H M Reul; Angela Gesing; Mary P Stenzel-Poore; Florian Holsboer; Thomas Steckler
Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge.
Genes, brain, and behavior 2002;1(3):174-7.
2002: Martin E Keck; Tobias Welt; Marianne B Müller; Erhardt Angelika; frauke ohl; Nicola Toschi; Florian Holsboer; Inge Sillaber
Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system.
Neuropharmacology 2002;43(1):101-9.
2002: Marike Lancel; Peter Müller-Preuss; Alexandra Wigger; Rainer Landgraf; Florian Holsboer
The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety.
Journal of psychiatric research 2002;36(4):197-208.
2002: Damian Kovalovsky; Damian Refojo; Ana C Liberman; Daniel Hochbaum; Marcelo Paez Pereda; Omar A Coso; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1638-51.
2002: Erina M Schumann; Tania Kümpfel; Florian Then Bergh; Claudia Trenkwalder; Florian Holsboer; Dorothee P Auer
Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume.
Annals of neurology 2002;51(6):763-7.
2002: Marcel M van Gaalen; Mary P Stenzel-Poore; Florian Holsboer; Thomas Steckler
Effects of transgenic overproduction of CRH on anxiety-like behaviour.
The European journal of neuroscience 2002;15(12):2007-15.
2002: frauke ohl; Angelika Roedel; Corinna Storch; Florian Holsboer; Rainer Landgraf
Cognitive performance in rats differing in their inborn anxiety.
Behavioral neuroscience 2002;116(3):464-71.
2002: G Alexander Abel; Gabriela M Wochnik; Joëlle Rüegg; Audrey Rouyer; Florian Holsboer; Theo Rein
Activity of the GR in G2 and mitosis.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1352-66.
2002: Inge Sillaber; Gerhard Rammes; Stephan Zimmermann; Beatrice Mahal; Walter Zieglgänsberger; Wolfgang Wurst; Florian Holsboer; Rainer Spanagel
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
Science (New York, N.Y.) 2002;296(5569):931-3.
2002: Michael Czisch; Thomas C Wetter; Christian Kaufmann; Thomas Pollmächer; Florian Holsboer; Dorothee P Auer
Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study.
NeuroImage 2002;16(1):251-8.
2002: Jobst Landgrebe; Gerhard Welzl; T Metz; Marcel M van Gaalen; H Ropers; Wolfgang Wurst; Florian Holsboer
Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling.
Journal of psychiatric research 2002;36(3):119-29.
2002: Marianne Müller; Florian Holsboer; Martin E Keck
Genetic modification of corticosteroid receptor signalling: novel insights into pathophysiology and treatment strategies of human affective disorders.
Neuropeptides 2002;36(2-3):117-31.
2002: Christian Otte; Michael Kellner; Josef Arlt; Holger Jahn; Florian Holsboer; Klaus Wiedemann
Prolactin but not ACTH increases during sodium lactate-induced panic attacks.
Psychiatry research 2002;109(2):201-5.
2002: Johannes M H M Reul; Florian Holsboer
On the role of corticotropin-releasing hormone receptors in anxiety and depression.
Dialogues in clinical neuroscience 2002;4(1):31-46.
2002: Alicia Bilang-Bleuel; J Rech; Sonja De Carli; Florian Holsboer; Johannes M H M Reul
Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat.
The European journal of neuroscience 2002;15(6):1048-60.
2002: Anke Post; Monika Rücker; frauke ohl; Manfred Uhr; Florian Holsboer; Osborne Almeida; Theologos M Michaelidis
Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(3):397-407.
2002: Johannes M H M Reul; Florian Holsboer
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.
Current opinion in pharmacology 2002;2(1):23-33.
2002: Lionel Muller Igaz; Damian Refojo; Monica Costas; Florian Holsboer; Eduardo Arzt
CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death.
Biochimica et biophysica acta 2002;1542(1-3):139-48.
2002: Rosana G Peñalva; Cornelia Flachskamm; Stephan Zimmermann; Wolfgang Wurst; Florian Holsboer; Johannes M H M Reul; Astrid C E Linthorst
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice.
Neuroscience 2002;109(2):253-66.
2002: Andreas Ströhle; Elena Romeo; Flavia di Michele; Augusto Pasini; Alexander Yassouridis; Florian Holsboer; Rainer Rupprecht
GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment.
The American journal of psychiatry 2002;159(1):145-7.
2002: Martin E Keck; Alexandra Wigger; Tobias Welt; Marianne B Müller; Angela Gesing; Johannes M H M Reul; Florian Holsboer; Rainer Landgraf; Inga D Neumann
Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(1):94-105.
2001: Marianne B Müller; P J Lucassen; A Yassouridis; W J Hoogendijk; Florian Holsboer; Dick F Swaab
Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.
The European journal of neuroscience 2001;14(10):1603-12.
2001: Sieglinde Modell; Florian Holsboer
Current scientific programmes in German neurosciences: supported by official sponsors.
Pharmacopsychiatry 2001;34(6):I-VII.
2001: Rainer Rupprecht; Flavia di Michele; Bettina Hermann; Andreas Ströhle; Marike Lancel; Elena Romeo; Florian Holsboer
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology.
Brain research. Brain research reviews 2001;37(1-3):59-67.
2001: J Preil; Marianne B Müller; Angela Gesing; Johannes M H M Reul; Inge Sillaber; Marcel M van Gaalen; Jobst Landgrebe; Florian Holsboer; Mary P Stenzel-Poore; Wolfgang Wurst
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2.
Endocrinology 2001;142(11):4946-55.
2001: Florian Holsboer
Antidepressant drug discovery in the postgenomic era.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2001;2(4):165-77.
2001: Andreas Ströhle; M Kellner; Florian Holsboer; Klaus Wiedemann
Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder.
The American journal of psychiatry 2001;158(9):1514-6.
2001: Marianne B Müller; J Preil; Ulrich Renner; Stephan Zimmermann; Adelheid E Kresse; Günter K Stalla; Martin E Keck; Florian Holsboer; Wolfgang Wurst
Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation.
Endocrinology 2001;142(9):4150-3.
2001: Damian Refojo; Ana C Liberman; Florian Holsboer; Eduardo Arzt
Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids.
Immunology and cell biology 2001;79(4):385-94.
2001: Andreas Stefferl; Maria K Storch; Christopher Linington; Christine Stadelmann; Hans Lassmann; T Pohl; Florian Holsboer; Fred J H Tilders; Johannes M H M Reul
Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone.
Endocrinology 2001;142(8):3616-24.
2001: Thomas Steckler; Florian Holsboer
Interaction between the cholinergic system and CRH in the modulation of spatial discrimination learning in mice.
Brain research 2001;906(1-2):46-59.
2001: Alexandra Wigger; P Loerscher; P Weissenbacher; Florian Holsboer; Rainer Landgraf
Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety.
Behavior genetics 2001;31(4):371-82.
2001: Florian Holsboer
Prospects for antidepressant drug discovery.
Biological psychology 2001;57(1-3):47-65.
2001: Angela Gesing; Alicia Bilang-Bleuel; Susanne K Droste; Astrid C E Linthorst; Florian Holsboer; Johannes M H M Reul
Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4822-9.
2001: frauke ohl; Inge Sillaber; Elisabeth B Binder; Martin E Keck; Florian Holsboer
Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test.
Journal of psychiatric research 2001;35(3):147-54.
2001: Wolfgang Hundt; Ulrich Zimmermann; M Pöttig; Konstanze Spring; Florian Holsboer
The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal.
Alcoholism, clinical and experimental research 2001;25(5):687-91.
2001: Martin E Keck; Florian Holsboer
Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders.
Peptides 2001;22(5):835-44.
2001: Florian Then Bergh; Tania Kümpfel; A Grasser; R Rupprecht; Florian Holsboer; Claudia Trenkwalder
Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial.
The Journal of clinical endocrinology and metabolism 2001;86(4):1610-5.
2001: P Schmidt; Florian Holsboer; Dietmar Spengler
Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.
Molecular endocrinology (Baltimore, Md.) 2001;15(4):553-64.
2001: Martin E Keck; Tobias Welt; Anke Post; Marianne B Müller; Nicola Toschi; Alexandra Wigger; Rainer Landgraf; Florian Holsboer; Mario Engelmann
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(4):337-49.
2001: Astrid Zobel; Thomas Nickel; Annette Sonntag; Manfred Uhr; Florian Holsboer; Marcus Ising
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study.
Journal of psychiatric research 2001;35(2):83-94.
2001: Marcus C Rosenhagen; Jason C Young; Gabriela M Wochnik; Alexandra S Herr; Ulrike Schmidt; F Ulrich Hartl; Florian Holsboer; Theo Rein
Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.
Biological chemistry 2001;382(3):499-504.
2001: T Steckler; Florian Holsboer
Conditioned activity to amphetamine in transgenic mice expressing an antisense RNA against the glucocorticoid receptor.
Behavioral neuroscience 2001;115(1):207-19.
2001: Elisabeth Friess; T Kuempfel; Juliane Winkelmann; D Schmid; Manfred Uhr; Rainer Rupprecht; Florian Holsboer; Claudia Trenkwalder
Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy.
Archives of neurology 2001;58(2):241-6.
2001: Thomas Steckler; Gerhard Rammes; M Sauvage; Marcel M van Gaalen; C Weis; W Zieglgänsberger; Florian Holsboer
Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice.
Journal of psychiatric research 2001;35(1):29-42.
2001: Florian Holsboer
Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy.
Journal of affective disorders 2001;62(1-2):77-91.
2001: Jürgen-Christian Krieg; Christoph J Lauer; Wolfgang Schreiber; Sieglinde Modell; Florian Holsboer
Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the 'Munich vulnerability study'.
Journal of affective disorders 2001;62(1-2):33-7.
2001: Martin E Keck; Tobias Welt; Alexandra Wigger; Ulrich Renner; Mario Engelmann; Florian Holsboer; Rainer Landgraf
The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.
The European journal of neuroscience 2001;13(2):373-80.
2001: Andreas Schuld; Thomas Kraus; Monika Haack; Dunja Hinze-Selch; Astrid Zobel; Florian Holsboer; Thomas Pollmächer
Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients.
Psychoneuroendocrinology 2001;26(1):65-76.
2000: M Sauvage; Philippe Brabet; Florian Holsboer; Joël Bockaert; Thomas Steckler
Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks.
Brain research. Molecular brain research 2000;84(1-2):79-89.
2000: Andreas Schuld; Janet M Mullington; Elisabeth Friess; DM Hermann; C Galanos; Florian Holsboer; Thomas Pollmächer
Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.
The Journal of clinical endocrinology and metabolism 2000;85(12):4624-9.
2000: Florian Holsboer
The stress hormone system is back on the map.
Current psychiatry reports 2000;2(6):454-6.
2000: A Post; Christophe Crochemore; M Uhr; Florian Holsboer; Christian Behl
Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro.
The European journal of neuroscience 2000;12(12):4331-7.
2000: Marianne B Müller; Rainer Landgraf; J Preil; Inge Sillaber; Adelheid E Kresse; Martin E Keck; Stephan Zimmermann; Florian Holsboer; Wolfgang Wurst
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
Endocrinology 2000;141(11):4262-9.
2000: Florian Holsboer
The corticosteroid receptor hypothesis of depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(5):477-501.
2000: Tania Kümpfel; Florian Then Bergh; Thomas Pollmächer; Florian Holsboer; Claudia Trenkwalder
Acute effects of interferon beta-1a on plasma cytokine levels in patients with MS.
Neurology 2000;55(8):1231-3.
2000: Andreas Schuld; Werner Blum; Manfred Uhr; Monika Haack; T Kraus; Florian Holsboer; Thomas Pollmächer
Reduced leptin levels in human narcolepsy.
Neuroendocrinology 2000;72(4):195-8.
2000: Martin E Keck; Inge Sillaber; Karl Ebner; Tobias Welt; Nicola Toschi; Stefan T Kaehler; Nicolas Singewald; Athineos Philippou; Gregor Elbel; Carsten T Wotjak; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain.
The European journal of neuroscience 2000;12(10):3713-20.
2000: Johannes M H M Reul; Angela Gesing; Susanne K Droste; IS Stec; A Weber; Cornelius G Bachmann; Alicia Bilang-Bleuel; Florian Holsboer; Astrid C E Linthorst
The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.
European journal of pharmacology 2000;405(1-3):235-49.
2000: Damian Kovalovsky; Damian Refojo; Florian Holsboer; Eduardo Arzt
Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.
Journal of neuroimmunology 2000;109(1):23-9.
2000: Bettina Hermann; R Landgraf; Martin E Keck; Alexandra Wigger; A Leslie Morrow; Andreas Ströhle; Florian Holsboer; Rainer Rupprecht
Pharmacological characterisation of cortical gamma-aminobutyric acid type A (GABAA) receptors in two Wistar rat lines selectively bred for high and low anxiety-related behaviour.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2000;1(3):137-43.
2000: Thomas Steckler; M Sauvage; Florian Holsboer
Glucocorticoid receptor impairment enhances impulsive responding in transgenic mice performing on a simultaneous visual discrimination task.
The European journal of neuroscience 2000;12(7):2559-69.
2000: Isabella Heuser; Michael Deuschle; B Weber; Günter K Stalla; Florian Holsboer
Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone.
Psychoneuroendocrinology 2000;25(5):513-8.
2000: Marianne B Müller; Martin E Keck; Stephan Zimmermann; Florian Holsboer; Wolfgang Wurst
Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids.
Neuroreport 2000;11(9):1963-6.
2000: Irina A Antonijevic; Harald Murck; S Bohlhalter; Ralf-Michael Frieboes; Florian Holsboer; Axel Steiger
Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men.
Neuropharmacology 2000;39(8):1474-81.
2000: Thomas Schiffelholz; Florian Holsboer; Marike Lancel
High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats.
Physiology & behavior 2000;69(4-5):399-404.
2000: Andreas Ströhle; Augusto Pasini; Elena Romeo; Bettina Hermann; Gianfranco Spalletta; Flavia di Michele; Florian Holsboer; Rainer Rupprecht
Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression.
Journal of psychiatric research 2000;34(3):183-6.
2000: Astrid Zobel; Thomas Nickel; Heike E Künzel; Nibal Ackl; Annette Sonntag; Marcus Ising; Florian Holsboer
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.
Journal of psychiatric research 2000;34(3):171-81.
2000: Hirokuni Tagaya; Lorenz Trachsel; Harald Murck; Irina A Antonijevic; Axel Steiger; Florian Holsboer; Elisabeth Friess
Temporal EEG dynamics of non-REM sleep episodes in humans.
Brain research 2000;861(2):233-40.
2000: Martin E Keck; M Hatzinger; Carsten T Wotjak; Rainer Landgraf; Florian Holsboer; Inga D Neumann
Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats.
The European journal of neuroscience 2000;12(4):1487-94.
2000: Janet M Mullington; C Korth; DM Hermann; A Orth; C Galanos; Florian Holsboer; Thomas Pollmächer
Dose-dependent effects of endotoxin on human sleep.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R947-55.
2000: Osborne Almeida; G L Condé; Christophe Crochemore; B A Demeneix; Dieter Fischer; AH Hassan; M Meyer; Florian Holsboer; Theologos M Michaelidis
Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):779-90.
2000: Alexandra S Herr; Gabriela M Wochnik; Marcus C Rosenhagen; Florian Holsboer; Theo Rein
Rifampicin is not an activator of glucocorticoid receptor.
Molecular pharmacology 2000;57(4):732-7.
2000: Manfred Uhr; Thomas Steckler; Alexander Yassouridis; Florian Holsboer
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(4):380-7.
2000: Inga D Neumann; Alexandra Wigger; Luz Torner; Florian Holsboer; Rainer Landgraf
Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus.
Journal of neuroendocrinology 2000;12(3):235-43.
2000: Andreas Ströhle; Florian Holsboer; Rainer Rupprecht
Increased ACTH concentrations associated with cholecystokinin tetrapeptide-induced panic attacks in patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(3):251-6.
2000: Dorothee P Auer; Benno Pütz; Eduard Kraft; B Lipinski; Julia Schill; Florian Holsboer
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Biological psychiatry 2000;47(4):305-13.
2000: M Hatzinger; Carsten T Wotjak; T Naruo; R Simchen; Martin E Keck; Rainer Landgraf; Florian Holsboer; Inga D Neumann
Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats.
The Journal of endocrinology 2000;164(2):197-205.
2000: M Kellner; Klaus Wiedemann; Alexander Yassouridis; R Levengood; L S Guo; Florian Holsboer; Rachel Yehuda
Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder.
Biological psychiatry 2000;47(2):107-11.
2000: Eduardo Arzt; Damian Kovalovsky; Lionel Igaz; Monica Costas; Paola V Plazas; Damian Refojo; Marcelo Páez-Pereda; Johannes M H M Reul; Günter K Stalla; Florian Holsboer
Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action.
Annals of the New York Academy of Sciences 2000;917():672-7.
2000: Johannes M H M Reul; Alicia Bilang-Bleuel; Susanne K Droste; Astrid C E Linthorst; Florian Holsboer; Angela Gesing
New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders.
Zeitschrift für Rheumatologie 2000;59 Suppl 2():II/22-5.
2000: Astrid C E Linthorst; Cornelia Flachskamm; Nicholas Barden; Florian Holsboer; Johannes M H M Reul
Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice.
The European journal of neuroscience 2000;12(1):283-91.
1999: Tania Kümpfel; Florian Then Bergh; Elisabeth Friess; Manfred Uhr; Alexander Yassouridis; Claudia Trenkwalder; Florian Holsboer
Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis.
Neuroendocrinology 1999;70(6):431-8.
1999: Thomas Steckler; Florian Holsboer
Corticotropin-releasing hormone receptor subtypes and emotion.
Biological psychiatry 1999;46(11):1480-508.
1999: Christian Behl; Florian Holsboer
The female sex hormone oestrogen as a neuroprotectant.
Trends in pharmacological sciences 1999;20(11):441-4.
1999: Andreas Stefferl; Christopher Linington; Florian Holsboer; Johannes M H M Reul
Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat.
Endocrinology 1999;140(11):4932-8.
1999: Mario Engelmann; Karl Ebner; Rainer Landgraf; Florian Holsboer; C T Wotjak1
Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats.
Journal of neuroendocrinology 1999;11(11):867-72.
1999: Irina A Antonijevic; Harald Murck; Ralf-Michael Frieboes; Florian Holsboer; Axel Steiger
On the gender differences in sleep-endocrine regulation in young normal humans.
Neuroendocrinology 1999;70(4):280-7.
1999: Florian Then Bergh; Tania Kümpfel; Claudia Trenkwalder; R Rupprecht; Florian Holsboer
Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS.
Neurology 1999;53(4):772-7.
1999: Damian Kovalovsky; Marcelo Paez Pereda; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Differential regulation of interleukin-1 receptor antagonist by proopiomelanocortin peptides adrenocorticotropic hormone and beta-endorphin.
Neuroimmunomodulation 1999;6(5):367-72.
1999: Rainer Rupprecht; Florian Holsboer
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Trends in neurosciences 1999;22(9):410-6.
1999: Thomas Stoehr; Osborne Almeida; Rainer Landgraf; T S Shippenberg; Florian Holsboer; Rainer Spanagel
Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats.
Behavioural brain research 1999;103(1):85-93.
1999: Thomas Steckler; Florian Holsboer
Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function.
Behavioural brain research 1999;102(1-2):151-63.
1999: CH Wetzel; Helmut Vedder; Florian Holsboer; Walter Zieglgänsberger; RA Deisz
Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons.
British journal of pharmacology 1999;127(4):863-8.
1999: Astrid Zobel; Alexander Yassouridis; Ralf-Michael Frieboes; Florian Holsboer
Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression.
The American journal of psychiatry 1999;156(6):949-51.
1999: Rainer Landgraf; Alexandra Wigger; Florian Holsboer; Inga D Neumann
Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour.
Journal of neuroendocrinology 1999;11(6):405-7.
1999: Florian Holsboer
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.
Journal of psychiatric research 1999;33(3):181-214.
1999: Florian Then Bergh; A Grasser; Claudia Trenkwalder; Herbert Backmund; Florian Holsboer; R Rupprecht
Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
Journal of neurology 1999;246(4):292-8.
1999: Thomas Steckler; C Weis; M Sauvage; Anna Mederer; Florian Holsboer
Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function.
Behavioural brain research 1999;100(1-2):77-89.
1999: Andreas Schuld; Janet M Mullington; D Hermann; Dunja Hinze-Selch; T Fenzel; Florian Holsboer; Thomas Pollmächer
Effects of granulocyte colony-stimulating factor on night sleep in humans.
The American journal of physiology 1999;276(4 Pt 2):R1149-55.
1999: G Liebsch; Rainer Landgraf; Mario Engelmann; P Lörscher; Florian Holsboer
Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain.
Journal of psychiatric research 1999;33(2):153-63.
1999: Karl Ebner; Carsten T Wotjak; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Vasopressin released within the septal brain area during swim stress modulates the behavioural stress response in rats.
The European journal of neuroscience 1999;11(3):997-1002.
1999: Andreas Ströhle; M Kellner; Florian Holsboer; Klaus Wiedemann
Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder.
Biological psychiatry 1999;45(3):321-6.
1999: Andreas Ströhle; Elena Romeo; Bettina Hermann; Augusto Pasini; Gianfranco Spalletta; Flavia di Michele; Florian Holsboer; Rainer Rupprecht
Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery.
Biological psychiatry 1999;45(3):274-7.
1999: Carolina Perez-Castro; Rosana G Peñalva; Marcelo Páez-Pereda; Ulrich Renner; Johannes M H M Reul; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response.
Endocrinology 1999;140(2):690-7.
1999: Florian Holsboer
Neuroendocrine studies and antidepressant drug development.
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 1999;101(9):711-6.
1999: Ralf-Michael Frieboes; Ulrich Müller; Harald Murck; D Yves von Cramon; Florian Holsboer; Axel Steiger
Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury.
The Journal of neuropsychiatry and clinical neurosciences 1999;11(3):354-60.
1999: Rainer Rupprecht; Florian Holsboer
Neuropsychopharmacological properties of neuroactive steroids.
Steroids 1999;64(1-2):83-91.
1999: Astrid C E Linthorst; S Karanth; Nicholas Barden; Florian Holsboer; M H Reul
Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin.
The European journal of neuroscience 1999;11(1):178-86.
1999: Marike Lancel; J Faulhaber; Florian Holsboer; Rainer Rupprecht
The GABA(A) receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone.
Psychopharmacology 1999;141(2):213-9.
1999: AH Hassan; Vladimir Patchev; P von Rosenstiel; Florian Holsboer; Osborne Almeida
Plasticity of hippocampal corticosteroid receptors during aging in the rat.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):115-22.
1998: Mario Engelmann; Rainer Landgraf; P Lörscher; C Conzelmann; JC Probst; Florian Holsboer; Johannes M H M Reul
Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats.
European journal of pharmacology 1998;361(1):17-26.
1998: Christoph J Lauer; Wolfgang Schreiber; Sieglinde Modell; Florian Holsboer; Jürgen-Christian Krieg
The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation.
Journal of psychiatric research 1998;32(6):393-401.
1998: Rainer Rupprecht; Andreas Ströhle; Bettina Hermann; Flavia di Michele; Gianfranco Spalletta; Augusto Pasini; Florian Holsboer; Elena Romeo
Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers.
Biological psychiatry 1998;44(9):912-4.
1998: G Liebsch; Astrid C E Linthorst; Inga D Neumann; Johannes M H M Reul; Florian Holsboer; Rainer Landgraf
Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):381-96.
1998: A Post; Florian Holsboer; Christian Behl
Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8236-46.
1998: Christoph J Lauer; Detlev von Zerssen; Wolfgang Schreiber; Sieglinde Modell; Florian Holsboer; Jürgen-Christian Krieg
The pre-morbid psychometric profile is stable over time in subjects at high familial risk for affective disorders.
Journal of affective disorders 1998;51(1):45-53.
1998: Klaus Wiedemann; M Hirschmann; K Knaudt; R Rupprecht; F E Seier; Florian Holsboer
Sleep endocrine effects of megestrol acetate in healthy men.
Journal of neuroendocrinology 1998;10(9):719-27.
1998: CH Wetzel; B Hermann; Christian Behl; E Pestel; Gerhard Rammes; Walter Zieglgänsberger; Florian Holsboer; Rainer Rupprecht
Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor.
Molecular endocrinology (Baltimore, Md.) 1998;12(9):1441-51.
1998: G Liebsch; Alexandra Montkowski; Florian Holsboer; Rainer Landgraf
Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour.
Behavioural brain research 1998;94(2):301-10.
1998: Carsten T Wotjak; J Ganster; G Kohl; Florian Holsboer; Rainer Landgraf; Mario Engelmann
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons.
Neuroscience 1998;85(4):1209-22.
1998: Thomas Skutella; JC Probst; Ulrich Renner; Florian Holsboer; Christian Behl
Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety.
Neuroscience 1998;85(3):795-805.
1998: Dunja Hinze-Selch; EW Becker; Gerburg M Stein; Peter A Berg; Janet M Mullington; Florian Holsboer; Thomas Pollmächer
Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(2):114-22.
1998: Inga D Neumann; Alexandra Wigger; G Liebsch; Florian Holsboer; Rainer Landgraf
Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour.
Psychoneuroendocrinology 1998;23(5):449-63.
1998: Damian Kovalovsky; Marcelo Páez-Pereda; J Sauer; Carolina Perez-Castro; Victor E Nahmod; Günter K Stalla; Florian Holsboer; Eduardo Arzt
The Th1 and Th2 cytokines IFN-gamma and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: involvement of IL-1.
European journal of immunology 1998;28(7):2075-85.
1998: Inge Sillaber; Alexandra Montkowski; Rainer Landgraf; Nicholas Barden; Florian Holsboer; Rainer Spanagel
Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide.
Neuroscience 1998;85(2):415-25.
1998: A Ströhle; M Poettig; Nicholas Barden; Florian Holsboer; Alexandra Montkowski
Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction.
Neuroreport 1998;9(9):2099-102.
1998: P Timpl; Rainer Spanagel; Inge Sillaber; Adelheid E Kresse; Johannes M H M Reul; Günter K Stalla; V Blanquet; Thomas Steckler; Florian Holsboer; Wolfgang Wurst
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nature genetics 1998;19(2):162-6.
1998: Alexandra Montkowski; Holger Jahn; A Ströhle; M Poettig; Florian Holsboer; Klaus Wiedemann
C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats.
Brain research 1998;792(2):358-60.
1998: Eduardo Arzt; Marcelo Páez-Pereda; Monica Costas; J Sauer; Ulrich Renner; Florian Holsboer; Günter K Stalla
Cytokine expression and molecular mechanisms of their auto/paracrine regulation of anterior pituitary function and growth.
Annals of the New York Academy of Sciences 1998;840():525-31.
1998: Andreas Ströhle; M Kellner; Alexander Yassouridis; Florian Holsboer; Klaus Wiedemann
Effect of flumazenil in lactate-sensitive patients with panic disorder.
The American journal of psychiatry 1998;155(5):610-2.
1998: F Lezoualc'h; Y Sagara; Florian Holsboer; Christian Behl
High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(9):3224-32.
1998: Dunja Hinze-Selch; Thomas C Wetter; Y Zhang; H C Lu; Ekkehard D Albert; Janet M Mullington; H Wekerle; Florian Holsboer; Thomas Pollmächer
In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
Neurology 1998;50(4):1149-52.
1998: Sieglinde Modell; Christoph J Lauer; Wolfgang Schreiber; Johannes Huber; Jürgen-Christian Krieg; Florian Holsboer
Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(4):253-62.
1998: Christian Behl; Florian Holsboer
[Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection].
Fortschritte der Neurologie-Psychiatrie 1998;66(3):113-21.
1998: Andreas Ströhle; M Kellner; Florian Holsboer; Klaus Wiedemann
Atrial natriuretic hormone decreases endocrine response to a combined dexamethasone-corticotropin-releasing hormone test.
Biological psychiatry 1998;43(5):371-5.
1998: Isabella Heuser; Garth Bissette; Michael Dettling; U Schweiger; U Gotthardt; Jürgen Schmider; Claas-Hinrich Lammers; Charles Nemeroff; Florian Holsboer
Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment.
Depression and anxiety 1998;8(2):71-9.
1998: U Hemmeter; B Rothe; J Guldner; Florian Holsboer; Axel Steiger
Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers.
Neuropsychobiology 1998;38(1):25-31.
1998: M Kellner; K Knaudt; Holger Jahn; Florian Holsboer; Klaus Wiedemann
Atrial natriuretic hormone in lactate-induced panic attacks: mode of release and endocrine and pathophysiological consequences.
Journal of psychiatric research 1998;32(1):37-48.
1998: Klaus Wiedemann; Christoph J Lauer; M Hirschmann; K Knaudt; Florian Holsboer
Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men.
The American journal of physiology 1998;274(1 Pt 1):E139-45.
1997: Klaus Wiedemann; Florian Holsboer
The effect of repeated human corticotropin-releasing hormone administration on dexamethasone-suppressed pituitary-adrenocortical activity in healthy subjects.
Biological psychiatry 1997;42(10):882-8.
1997: Axel Steiger; Florian Holsboer
Neuropeptides and human sleep.
Sleep 1997;20(11):1038-52.
1997: Marike Lancel; Stefan Mathias; Thomas Schiffelholz; Christian Behl; Florian Holsboer
Soluble tumor necrosis factor receptor (p75) does not attenuate the sleep changes induced by lipopolysaccharide in the rat during the dark period.
Brain research 1997;770(1-2):184-91.
1997: Axel Steiger; Florian Holsboer
Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission.
Psychiatry research 1997;72(2):81-8.
1997: J Guldner; T Schier; Elisabeth Friess; M Colla; Florian Holsboer; Axel Steiger
Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly.
Neurobiology of aging 1997;18(5):491-5.
1997: Nicholas Barden; IS Stec; Alexandra Montkowski; Florian Holsboer; Johannes M H M Reul
Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor.
Neuroendocrinology 1997;66(3):212-20.
1997: Marike Lancel; J Faulhaber; Thomas Schiffelholz; Elena Romeo; Flavia di Michele; Florian Holsboer; Rainer Rupprecht
Allopregnanolone affects sleep in a benzodiazepine-like fashion.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1213-8.
1997: S Karanth; Astrid C E Linthorst; Günter K Stalla; Nicholas Barden; Florian Holsboer; Johannes M H M Reul
Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function.
Endocrinology 1997;138(8):3476-85.
1997: B Schöbitz; G Pezeshki; JC Probst; Johannes M H M Reul; Thomas Skutella; Thomas Stoehr; Florian Holsboer; Rainer Spanagel
Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects.
European journal of pharmacology 1997;331(2-3):97-107.
1997: Alexandra Montkowski; M Poettig; Anna Mederer; Florian Holsboer
Behavioural performance in three substrains of mouse strain 129.
Brain research 1997;762(1-2):12-8.
1997: S Bohlhalter; Harald Murck; Florian Holsboer; Axel Steiger
Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects.
Neurobiology of aging 1997;18(4):423-9.
1997: Ralf-Michael Frieboes; Harald Murck; Klaus Wiedemann; Florian Holsboer; Axel Steiger
Open clinical trial on the sigma ligand panamesine in patients with schizophrenia.
Psychopharmacology 1997;132(1):82-8.
1997: Astrid C E Linthorst; Cornelia Flachskamm; Stephen J Hopkins; Margaret E Hoadley; Marta Labeur; Florian Holsboer; Johannes M H M Reul
Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4448-60.
1997: Christian Behl; T Trapp; Thomas Skutella; Florian Holsboer
Protection against oxidative stress-induced neuronal cell death--a novel role for RU486.
The European journal of neuroscience 1997;9(5):912-20.
1997: Elisabeth Friess; Hirokuni Tagaya; Lorenz Trachsel; Florian Holsboer; Rainer Rupprecht
Progesterone-induced changes in sleep in male subjects.
The American journal of physiology 1997;272(5 Pt 1):E885-91.
1997: Ralf-Michael Frieboes; Harald Murck; T Schier; Florian Holsboer; Axel Steiger
Somatostatin impairs sleep in elderly human subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(5):339-45.
1997: M Kellner; Alexander Yassouridis; B Manz; Axel Steiger; Florian Holsboer; Klaus Wiedemann
Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?
Neuroendocrinology 1997;65(4):284-90.
1997: Christian Behl; Thomas Skutella; F Lezoualc'h; A Post; M Widmann; Christopher J Newton; Florian Holsboer
Neuroprotection against oxidative stress by estrogens: structure-activity relationship.
Molecular pharmacology 1997;51(4):535-41.
1997: Christoph J Lauer; Thomas Bronisch; M Kainz; Wolfgang Schreiber; Florian Holsboer; Jürgen-Christian Krieg
Pre-morbid psychometric profile of subjects at high familial risk for affective disorder.
Psychological medicine 1997;27(2):355-62.
1997: T Schier; J Guldner; M Colla; Florian Holsboer; Axel Steiger
Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration.
Journal of neuroendocrinology 1997;9(3):201-5.
1997: Sieglinde Modell; Alexander Yassouridis; Johannes Huber; Florian Holsboer
Corticosteroid receptor function is decreased in depressed patients.
Neuroendocrinology 1997;65(3):216-22.
1997: A Ströhle; Holger Jahn; Alexandra Montkowski; G Liebsch; E Boll; Rainer Landgraf; Florian Holsboer; Klaus Wiedemann
Central and peripheral administration of atriopeptin is anxiolytic in rats.
Neuroendocrinology 1997;65(3):210-5.
1997: Johannes M H M Reul; JC Probst; Thomas Skutella; M Hirschmann; IS Stec; Alexandra Montkowski; Rainer Landgraf; Florian Holsboer
Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.
Neuroendocrinology 1997;65(3):189-99.
1997: Vladimir Patchev; Alexandra Montkowski; D Rouskova; L Koranyi; Florian Holsboer; Osborne Almeida
Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.
The Journal of clinical investigation 1997;99(5):962-6.
1997: Alexandra Montkowski; Florian Holsboer
Intact spatial learning and memory in transgenic mice with reduced BDNF.
Neuroreport 1997;8(3):779-82.
1997: Thomas Skutella; R K Schwarting; J P Huston; Inge Sillaber; JC Probst; Florian Holsboer; Rainer Spanagel
Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour.
The European journal of neuroscience 1997;9(2):210-20.
1997: Osborne Almeida; V Canoine; S Ali; Florian Holsboer; Vladimir Patchev
Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression.
Journal of neuroendocrinology 1997;9(2):129-34.
1997: T Pollmãcher; Dunja Hinze-Selch; Janet M Mullington; T Fenzel; Florian Holsboer
Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia.
Archives of general psychiatry 1997;54(1):89-90.
1997: Christoph J Lauer; Wolfgang Schreiber; Thomas Pollmächer; Florian Holsboer; Jürgen-Christian Krieg
Sleep in schizophrenia: a polysomnographic study on drug-naive patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(1):51-60.
1997: Christian Behl; F Lezoualc'h; T Trapp; M Widmann; Thomas Skutella; Florian Holsboer
Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro.
Endocrinology 1997;138(1):101-6.
1996: Carsten T Wotjak; M Kubota; G Liebsch; Alexandra Montkowski; Florian Holsboer; I Neumann; Rainer Landgraf
Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion?
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7725-32.
1996: M Hatzinger; Johannes M H M Reul; Rainer Landgraf; Florian Holsboer; I Neumann
Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging.
Neuroendocrinology 1996;64(5):349-56.
1996: Thomas Pollmächer; Janet M Mullington; C Korth; Wolfgang Schreiber; D Hermann; A Orth; C Galanos; Florian Holsboer
Diurnal variations in the human host response to endotoxin.
The Journal of infectious diseases 1996;174(5):1040-5.
1996: F Lezoualc'h; Rainer Rupprecht; Florian Holsboer; Christian Behl
Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol.
Brain research 1996;738(1):176-9.
1996: Harald Murck; J Guldner; M Colla-Müller; Ralf-Michael Frieboes; T Schier; Klaus Wiedemann; Florian Holsboer; Axel Steiger
VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men.
The American journal of physiology 1996;271(4 Pt 2):R905-11.
1996: Marike Lancel; J Faulhaber; Florian Holsboer; Rainer Rupprecht
Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators.
The American journal of physiology 1996;271(4 Pt 1):E763-72.
1996: M Costas; T Trapp; Marcelo Paez Pereda; J Sauer; R Rupprecht; V E Nahmod; Johannes M H M Reul; Florian Holsboer; Monica Costas
Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.
The Journal of clinical investigation 1996;98(6):1409-16.
1996: Janet M Mullington; D Hermann; Florian Holsboer; Thomas Pollmächer
Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.
Neuroendocrinology 1996;64(3):233-41.
1996: B Hermann; Christian H Wetzel; E Pestel; Walter Zieglgänsberger; Florian Holsboer; Rainer Rupprecht
Functional antagonistic properties of clozapine at the 5-HT3 receptor.
Biochemical and biophysical research communications 1996;225(3):957-60.
1996: Marcelo Páez-Pereda; Carolina Perez-Castro; M Costas; V E Nahmod; Günter K Stalla; Florian Holsboer; Monica Costas
Glucocorticoids inhibit the autoregulatory induction of interleukin-1 in monocytes after endotoxin stimulation.
Neuroimmunomodulation 1996;3(4):227-32.
1996: Wolfgang Schreiber; Christoph J Lauer; K Krumrey; Florian Holsboer; Jürgen-Christian Krieg
Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(1):7-15.
1996: A H Hassan; P von Rosenstiel; Vladimir Patchev; Florian Holsboer; Osborne Almeida
Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone.
Experimental neurology 1996;140(1):43-52.
1996: Astrid C E Linthorst; C Flachskamm; Florian Holsboer; Johannes M H M Reul
Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway.
Neuroscience 1996;72(4):989-97.
1996: Rainer Rupprecht; B Berning; C A Hauser; Florian Holsboer; Johannes M H M Reul
Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship.
European journal of pharmacology 1996;303(3):227-34.
1996: Mario Engelmann; Kv Thrivikraman; Y Su; Charles Nemeroff; Alexandra Montkowski; Rainer Landgraf; Florian Holsboer; Paul M Plotsky
Endocrine and behavioral effects of airpuff-startle in rats.
Psychoneuroendocrinology 1996;21(4):391-400.
1996: Christian Behl; F Lezoulac'h; M Widmann; Rainer Rupprecht; Florian Holsboer
Oxidative stress-resistant cells are protected against haloperidol toxicity.
Brain research 1996;717(1-2):193-5.
1996: T Trapp; Florian Holsboer
Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action.
Trends in pharmacological sciences 1996;17(4):145-9.
1996: Florian Holsboer; N Barden
Antidepressants and hypothalamic-pituitary-adrenocortical regulation.
Endocrine reviews 1996;17(2):187-205.
1996: C A Hauser; Christian H Wetzel; Rainer Rupprecht; Florian Holsboer
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Biochemical and biophysical research communications 1996;219(2):531-6.
1996: B Spanagel; Thomas Stoehr; N Barden; Florian Holsboer
Morphine-induced locomotor and neurochemical stimulation is enhanced in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1996;8(2):93-7.
1996: Thomas Pollmächer; C Korth; Janet M Mullington; Wolfgang Schreiber; J Sauer; Helmut Vedder; C Galanos; Florian Holsboer
Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men.
Blood 1996;87(3):900-5.
1996: A Sonntag; B Rothe; J Guldner; Alexander Yassouridis; Florian Holsboer; Axel Steiger
Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression.
Depression 1996;4(1):1-13.
1996: A Hartmann; K Krumrey; Luise Vogl; Gerhard Dirlich; Florian Holsboer; M Heuser-Link
Changes in late auditory evoked potentials induced by corticotropin-releasing hormone and corticotropin fragment 4-9 in male controls.
Neuropsychobiology 1996;33(2):90-6.
1996: A Grasser; A Möller; Herbert Backmund; Alexander Yassouridis; Florian Holsboer
Heterogeneity of hypothalamic-pituitary-adrenal system response to a combined dexamethasone-CRH test in multiple sclerosis.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104(1):31-7.
1996: Rainer Rupprecht; C A Hauser; T Trapp; Florian Holsboer
Neurosteroids: molecular mechanisms of action and psychopharmacological significance.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):163-8.
1996: J Sauer; M Castren; Ursula Hopfner; Florian Holsboer; Günter K Stalla; Eduardo Arzt
Inhibition of lipopolysaccharide-induced monocyte interleukin-1 receptor antagonist synthesis by cortisol: involvement of the mineralocorticoid receptor.
The Journal of clinical endocrinology and metabolism 1996;81(1):73-9.
1996: Isabella Heuser; U Schweiger; U Gotthardt; Jürgen Schmider; Claas-Hinrich Lammers; M Dettling; Alexander Yassouridis; Florian Holsboer
Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects.
The American journal of psychiatry 1996;153(1):93-9.
1995: Christian Behl; Rainer Rupprecht; Thomas Skutella; Florian Holsboer
Haloperidol-induced cell death--mechanism and protection with vitamin E in vitro.
Neuroreport 1995;7(1):360-4.
1995: Claas-Hinrich Lammers; D Garcia-Borreguero; Jürgen Schmider; U Gotthardt; M Dettling; Florian Holsboer; Isabella Heuser
Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II.
Biological psychiatry 1995;38(12):803-7.
1995: Jürgen Schmider; Claas-Hinrich Lammers; U Gotthardt; M Dettling; Florian Holsboer; Isabella Heuser
Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I.
Biological psychiatry 1995;38(12):797-802.
1995: Astrid C E Linthorst; C Flachskamm; Florian Holsboer; Johannes M H M Reul
Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity.
The European journal of neuroscience 1995;7(12):2418-30.
1995: Rainer Spanagel; Alexandra Montkowski; K Allingham; Thomas Stoehr; M Shoaib; Florian Holsboer; Rainer Landgraf
Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats.
Psychopharmacology 1995;122(4):369-73.
1995: M Paez Pereda; J Sauer; Carolina Perez-Castro; Samuel Finkielman; Günter K Stalla; Florian Holsboer; Eduardo Arzt
Corticotropin-releasing hormone differentially modulates the interleukin-1 system according to the level of monocyte activation by endotoxin.
Endocrinology 1995;136(12):5504-10.
1995: M Kellner; Florian Holsboer; I Heuser
Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression.
Psychiatry research 1995;59(1-2):157-60.
1995: Christian Behl; M Widmann; T Trapp; Florian Holsboer
17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.
Biochemical and biophysical research communications 1995;216(2):473-82.
1995: J Guldner; L Trachsel; C Kratschmayr; B Rothe; Florian Holsboer; Axel Steiger
Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men.
Psychopharmacology 1995;122(2):115-21.
1995: Alexandra Montkowski; N Barden; Carsten T Wotjak; I Stec; J Ganster; M Meaney; Mario Engelmann; Johannes M H M Reul; Rainer Landgraf; Florian Holsboer
Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1995;7(11):841-5.
1995: G Liebsch; Rainer Landgraf; R Gerstberger; JC Probst; Carsten T Wotjak; Mario Engelmann; Florian Holsboer; Alexandra Montkowski
Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats.
Regulatory peptides 1995;59(2):229-39.
1995: T Trapp; Florian Holsboer
Ligand-induced conformational changes in the mineralocorticoid receptor analyzed by protease mapping.
Biochemical and biophysical research communications 1995;215(1):286-91.
1995: Florian Holsboer; C J Lauer; Wolfgang Schreiber; J C Krieg
Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders.
Neuroendocrinology 1995;62(4):340-7.
1995: Silvina Raiden; E Polack; V Nahmod; Marta Labeur; Florian Holsboer; Eduardo Arzt
TRH receptor on immune cells: in vitro and in vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH.
Journal of clinical immunology 1995;15(5):242-9.
1995: M Kellner; L Herzog; Alexander Yassouridis; Florian Holsboer; Klaus Wiedemann
Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic.
The American journal of psychiatry 1995;152(9):1365-7.
1995: M Castrén; Vladimir Patchev; Osborne Almeida; Florian Holsboer; T Trapp; Eero Castrén
Regulation of rat mineralocorticoid receptor expression in neurons by progesterone.
Endocrinology 1995;136(9):3800-6.
1995: G Jan Wiegers; Marta Labeur; I E Stec; W E Klinkert; Florian Holsboer; Johannes M H M Reul
Glucocorticoids accelerate anti-T cell receptor-induced T cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1893-902.
1995: E Seifritz; Ulrich M Hemmeter; L Trachsel; C J Lauer; Martin Hatzinger; H M Emrich; Florian Holsboer; Edith Holsboer-Trachsler
Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls.
Psychopharmacology 1995;120(4):449-56.
1995: Rainer Landgraf; R Gerstberger; Alexandra Montkowski; JC Probst; Carsten T Wotjak; Florian Holsboer; Mario Engelmann
V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4250-8.
1995: Marta Labeur; Eduardo Arzt; G Jan Wiegers; Florian Holsboer; Johannes M H M Reul
Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression.
Endocrinology 1995;136(6):2678-88.
1995: M Castrén; T Trapp; B Berninger; Eero Castrén; Florian Holsboer
Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids.
Journal of molecular endocrinology 1995;14(3):285-93.
1995: Marike Lancel; J Crönlein; P Müller-Preuss; Florian Holsboer
Lipopolysaccharide increases EEG delta activity within non-REM sleep and disrupts sleep continuity in rats.
The American journal of physiology 1995;268(5 Pt 2):R1310-8.
1995: B Schöbitz; G Pezeshki; T Pohl; U Hemmann; P C Heinrich; Florian Holsboer; Johannes M H M Reul
Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(8):659-64.
1995: Ralf-Michael Frieboes; Harald Murck; P Maier; T Schier; Florian Holsboer; Axel Steiger
Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man.
Neuroendocrinology 1995;61(5):584-9.
1995: U Gotthardt; U Schweiger; J Fahrenberg; Christoph J Lauer; Florian Holsboer; Isabella Heuser
Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression.
The American journal of physiology 1995;268(4 Pt 2):R865-73.
1995: Rainer Landgraf; I Neumann; Florian Holsboer; Q J Pittman
Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat.
The European journal of neuroscience 1995;7(4):592-8.
1995: Astrid C E Linthorst; C Flachskamm; P Müller-Preuss; Florian Holsboer; Johannes M H M Reul
Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2920-34.
1995: A Teschemacher; M L Zeise; Florian Holsboer; Walter Zieglgänsberger
The neuroactive steroid 5 alpha-tetrahydrodeoxycorticosterone increases GABAergic postsynaptic inhibition in rat neocortical neurons in vitro.
Journal of neuroendocrinology 1995;7(3):233-40.
1995: Christoph J Lauer; Wolfgang Schreiber; Florian Holsboer; Jürgen-Christian Krieg
In quest of identifying vulnerability markers for psychiatric disorders by all-night polysomnography.
Archives of general psychiatry 1995;52(2):145-53.
1995: Elisabeth Friess; L Trachsel; J Guldner; T Schier; Axel Steiger; Florian Holsboer
DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range.
The American journal of physiology 1995;268(1 Pt 1):E107-13.
1995: J Sauer; E Polack; S Wikinski; Florian Holsboer; Günter K Stalla; Eduardo Arzt
The glucocorticoid sensitivity of lymphocytes changes according to the activity of the hypothalamic-pituitary-adrenocortical system.
Psychoneuroendocrinology 1995;20(3):269-80.
1995: M Kellner; L Herzog; Florian Holsboer; Klaus Wiedemann
Circadian changes in the sensitivity of the corticotropin-releasing hormone-stimulated HPA system after arginine vasopressin and atrial natriuretic hormone in human male controls.
Psychoneuroendocrinology 1995;20(5):515-24.
1995: Elisabeth Friess; Klaus Wiedemann; Axel Steiger; Florian Holsboer
The hypothalamic-pituitary-adrenocortical system and sleep in man.
Advances in neuroimmunology 1995;5(2):111-25.
1995: A Hartmann; Thomas Dietl; K Krumrey; Luise Vogl; Gerhard Dirlich; Florian Holsboer; M Heuser-Link
Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls.
Peptides 1995;16(4):657-63.
1994: T Trapp; Rainer Rupprecht; M Castrén; Johannes M H M Reul; Florian Holsboer
Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.
Neuron 1994;13(6):1457-62.
1994: G Jan Wiegers; Johannes M H M Reul; Florian Holsboer; Ron de Kloet
Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro.
Endocrinology 1994;135(6):2351-7.
1994: K Damm; Rainer Rupprecht; Florian Holsboer
The binary corticosteroid response: transcriptional regulation by mineralo- and glucocorticoid receptors.
Annals of the New York Academy of Sciences 1994;746():79-87; discussion 87-8.
1994: Florian Holsboer; A Grasser; Elisabeth Friess; Klaus Wiedemann
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Annals of the New York Academy of Sciences 1994;746():345-59; discussion 359-61.
1994: U Schweiger; Michael Deuschle; A Körner; Claas-Hinrich Lammers; Jürgen Schmider; U Gotthardt; Florian Holsboer; Isabella Heuser
Low lumbar bone mineral density in patients with major depression.
The American journal of psychiatry 1994;151(11):1691-3.
1994: Johannes M H M Reul; Marta Labeur; D E Grigoriadis; E B De Souza; Florian Holsboer
Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide.
Neuroendocrinology 1994;60(5):509-19.
1994: Thomas Skutella; Hugh E Criswell; Sheryl S Moy; JC Probst; George R Breese; G F Jirikowski; Florian Holsboer
Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat.
Neuroreport 1994;5(16):2181-5.
1994: Thomas Skutella; Thomas Stoehr; JC Probst; F J Ramalho-Ortigao; Florian Holsboer; G F Jirikowski
Antisense oligodeoxynucleotides for in vivo targeting of corticotropin-releasing hormone mRNA: comparison of phosphorothioate and 3'-inverted probe performance.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1994;26(10):460-4.
1994: B Rothe; J Guldner; E Hohlfeldt; Christoph J Lauer; Thomas Pollmächer; Florian Holsboer; Axel Steiger
Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;11(2):101-6.
1994: Thomas Skutella; Alexandra Montkowski; Thomas Stoehr; JC Probst; Rainer Landgraf; Florian Holsboer; G F Jirikowski
Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats.
Cellular and molecular neurobiology 1994;14(5):579-88.
1994: Vladimir Patchev; M Shoaib; Florian Holsboer; Osborne Almeida
The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
Neuroscience 1994;62(1):265-71.
1994: Astrid C E Linthorst; C Flachskamm; Florian Holsboer; Johannes M H M Reul
Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature.
Endocrinology 1994;135(2):520-32.
1994: Klaus Wiedemann; Christoph J Lauer; Thomas Pollmächer; Florian Holsboer
Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males.
The American journal of physiology 1994;267(1 Pt 1):E109-14.
1994: Isabella Heuser; Alexander Yassouridis; Florian Holsboer
The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.
Journal of psychiatric research 1994;28(4):341-56.
1994: Johannes M H M Reul; I Stec; G Jan Wiegers; Marta Labeur; Astrid C E Linthorst; Eduardo Arzt; Florian Holsboer
Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats.
The Journal of clinical investigation 1994;93(6):2600-7.
1994: Marike Lancel; T A Crönlein; P Müller-Preuss; Florian Holsboer
Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam.
Brain research 1994;646(1):85-94.
1994: L Trachsel; Wolfgang Schreiber; Florian Holsboer; Thomas Pollmächer
Endotoxin enhances EEG alpha and beta power in human sleep.
Sleep 1994;17(2):132-9.
1994: Isabella Heuser; U Gotthardt; U Schweiger; Jürgen Schmider; Claas-Hinrich Lammers; M Dettling; Florian Holsboer
Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender.
Neurobiology of aging 1994;15(2):227-31.
1994: Eduardo Arzt; J Sauer; Thomas Pollmächer; Marta Labeur; Florian Holsboer; Johannes M H M Reul; Günter K Stalla
Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin.
Endocrinology 1994;134(2):672-7.
1994: I Stec; N Barden; Johannes M H M Reul; Florian Holsboer
Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor.
Journal of psychiatric research 1994;28(1):1-5.
1994: Axel Steiger; J Guldner; Christoph J Lauer; C Meschenmoser; Thomas Pollmächer; Florian Holsboer
Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls.
Psychopharmacology 1994;113(3-4):334-8.
1994: Axel Steiger; Otto Benkert; Florian Holsboer
Effects of long-term treatment with the MAO-A inhibitor moclobemide on sleep EEG and nocturnal hormonal secretion in normal men.
Neuropsychobiology 1994;30(2-3):101-5.
1993: G Jan Wiegers; G Croiset; Johannes M H M Reul; Florian Holsboer; Ron de Kloet
Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro.
The American journal of physiology 1993;265(6 Pt 1):E825-30.
1993: B Schöbitz; Ron de Kloet; W Sutanto; Florian Holsboer
Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain.
The European journal of neuroscience 1993;5(11):1426-35.
1993: Rainer Rupprecht; Johannes M H M Reul; B van Steensel; Dietmar Spengler; M Söder; B Berning; Florian Holsboer; K Damm
Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.
European journal of pharmacology 1993;247(2):145-54.
1993: Rainer Rupprecht; Johannes M H M Reul; T Trapp; B van Steensel; Christian H Wetzel; K Damm; Walter Zieglgänsberger; Florian Holsboer
Progesterone receptor-mediated effects of neuroactive steroids.
Neuron 1993;11(3):523-30.
1993: Axel Steiger; L Trachsel; J Guldner; Ulrich M Hemmeter; B Rothe; Rainer Rupprecht; Helmut Vedder; Florian Holsboer
Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation.
Brain research 1993;615(2):267-74.
1993: Johannes M H M Reul; I Stec; M Söder; Florian Holsboer
Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.
Endocrinology 1993;133(1):312-20.
1993: Axel Steiger; Rainer Rupprecht; Dietmar Spengler; J Guldner; Ulrich M Hemmeter; B Rothe; K Damm; Florian Holsboer
Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity.
Journal of psychiatric research 1993;27(3):275-84.
1993: Wolfgang Schreiber; Thomas Pollmächer; K Fassbender; S Gudewill; Helmut Vedder; Klaus Wiedemann; C Galanos; Florian Holsboer
Endotoxin- and corticotropin-releasing hormone-induced release of ACTH and cortisol. A comparative study in men.
Neuroendocrinology 1993;58(1):123-8.
1993: Isabella Heuser; M Heuser-Link; U Gotthardt; A Grasser; Florian Holsboer
Behavioral effects of a synthetic corticotropin 4-9 analog in patients with depression and patients with Alzheimer's disease.
Journal of clinical psychopharmacology 1993;13(3):171-4.
1993: Thomas Pollmächer; Wolfgang Schreiber; S Gudewill; Helmut Vedder; K Fassbender; Klaus Wiedemann; L Trachsel; C Galanos; Florian Holsboer
Influence of endotoxin on nocturnal sleep in humans.
The American journal of physiology 1993;264(6 Pt 2):R1077-83.
1993: Axel Steiger; A Gerken; Otto Benkert; Florian Holsboer
Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1993;3(2):117-26.
1993: Axel Steiger; Florian Holsboer; Otto Benkert
Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls.
Acta psychiatrica Scandinavica 1993;87(5):358-63.
1993: Rainer Rupprecht; J L Arriza; Dietmar Spengler; Johannes M H M Reul; R M Evans; Florian Holsboer; K Damm
Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1993;7(4):597-603.
1993: Helmut Vedder; I Weiss; Florian Holsboer; J M Reul
Glucocorticoid and mineralocorticoid receptors in rat neocortical and hippocampal brain cells in culture: characterization and regulatory studies.
Brain research 1993;605(1):18-24.
1993: Osborne Almeida; A H Hassan; Florian Holsboer
Intrahypothalamic neuroendocrine actions of corticotropin-releasing factor.
Ciba Foundation symposium 1993;172():151-69; discussion 169-72.
1993: Axel Steiger; U von Bardeleben; J Guldner; Christoph J Lauer; B Rothe; Florian Holsboer
The sleep EEG and nocturnal hormonal secretion studies on changes during the course of depression and on effects of CNS-active drugs.
Progress in neuro-psychopharmacology & biological psychiatry 1993;17(1):125-37.
1993: Helmut Vedder; F Parlow; Walter Zieglgänsberger; Florian Holsboer
Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells.
Experimental and clinical endocrinology 1993;101(3):161-5.
1992: D Garcia-Borreguero; Christoph J Lauer; A Ozdaglar; Klaus Wiedemann; Florian Holsboer; Jürgen-Christian Krieg
Brofaromine in panic disorder: a pilot study with a new reversible inhibitor of monoamine oxidase-A.
Pharmacopsychiatry 1992;25(6):261-4.
1992: Dietmar Spengler; Rainer Rupprecht; L P Van; Florian Holsboer
Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1931-41.
1992: Christoph J Lauer; Jürgen-Christian Krieg; D Garcia-Borreguero; A Ozdaglar; Florian Holsboer
Panic disorder and major depression: a comparative electroencephalographic sleep study.
Psychiatry research 1992;44(1):41-54.
1992: Axel Steiger; J Guldner; Ulrich M Hemmeter; B Rothe; Klaus Wiedemann; Florian Holsboer
Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls.
Neuroendocrinology 1992;56(4):566-73.
1992: B Schöbitz; Florian Holsboer; R Kikkert; W Sutanto; Ron de Kloet
Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats.
Endocrine regulations 1992;26(3):103-9.
1992: Wolfgang Schreiber; Christoph J Lauer; K Krumrey; Florian Holsboer; Jürgen-Christian Krieg
Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders.
Biological psychiatry 1992;32(1):79-90.
1992: Johannes M H M Reul; M Söder; Florian Holsboer
The hypothalamic-pituitary-adrenocortical (HPA) system and anti-depressive drug (AD) action.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():584A-585A.
1992: Florian Holsboer
Serotonin and sleep regulation.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():349A-350A.
1992: S Gudewill; Thomas Pollmächer; Helmut Vedder; Wolfgang Schreiber; K Fassbender; Florian Holsboer
Nocturnal plasma levels of cytokines in healthy men.
European archives of psychiatry and clinical neuroscience 1992;242(1):53-6.
1992: Florian Holsboer; K Wiedemann; R Rupprecht; A Steiger
Effects of corticosteroids and neurosteroids on sleep EEG.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():588A-589A.
1992: Florian Holsboer; Dietmar Spengler; I Heuser
The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia.
Progress in brain research 1992;93():385-417.
1992: Klaus Wiedemann; Christoph J Lauer; A Loycke; Thomas Pollmächer; P Durst; J P Machér; Florian Holsboer
Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern.
European archives of psychiatry and clinical neuroscience 1992;241(6):372-5.
1992: I J Heuser; Florian Holsboer
The CRH-stimulation test in affective and anxiety disorder: comparison to physical stress.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():159A-160A.
1992: M Kellner; Klaus Wiedemann; Florian Holsboer
Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man.
Life sciences 1992;50(24):1835-42.
1991: Klaus Wiedemann; U von Bardeleben; Florian Holsboer
Influence of human corticotropin-releasing hormone and adrenocorticotropin upon spontaneous growth hormone secretion.
Neuroendocrinology 1991;54(5):462-8.
1991: Hermann Wetzel; U von Bardeleben; Florian Holsboer; Otto Benkert
[Zotepine versus perazine in patients with paranoid schizophrenia: a double-blind controlled trial of its effectiveness].
Fortschritte der Neurologie-Psychiatrie 1991;59 Suppl 1():23-9.
1991: Axel Steiger; J Guldner; H Knisatschek; B Rothe; Christoph J Lauer; Florian Holsboer
Effects of an ACTH/MSH(4-9) analog (HOE 427) on the sleep EEG and nocturnal hormonal secretion in humans.
Peptides 1991;12(5):1007-10.
1991: Isabella Heuser; H J Wark; J Keul; Florian Holsboer
Hypothalamic-pituitary-adrenal axis function in elderly endurance athletes.
The Journal of clinical endocrinology and metabolism 1991;73(3):485-8.
1991: U von Bardeleben; Florian Holsboer
Effect of age on the cortisol response to human corticotropin-releasing hormone in depressed patients pretreated with dexamethasone.
Biological psychiatry 1991;29(10):1042-50.
1991: M Wiegand; A A Möller; Wolfgang Schreiber; Jürgen-Christian Krieg; Florian Holsboer
Alterations of nocturnal sleep in patients with HIV infection.
Acta neurologica Scandinavica 1991;83(2):141-2.
1991: I J Heuser; Florian Holsboer
Research activity at the Max Planck Institute for Psychiatry (Munich): depression in later life.
International psychogeriatrics / IPA 1991;3(1):75-8.
1991: M Wiegand; A A Möller; Wolfgang Schreiber; Jürgen-Christian Krieg; D Fuchs; H Wachter; Florian Holsboer
Nocturnal sleep EEG in patients with HIV infection.
European archives of psychiatry and clinical neuroscience 1991;240(3):153-8.
1991: Axel Steiger; U von Bardeleben; Klaus Wiedemann; Florian Holsboer
Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission.
Journal of psychiatric research 1991;25(4):169-77.
1991: Hermann Wetzel; Klaus Wiedemann; Florian Holsboer; Otto Benkert
Savoxepine: invalidation of an "atypical" neuroleptic response pattern predicted by animal models in an open clinical trial with schizophrenic patients.
Psychopharmacology 1991;103(2):280-3.
1990: H N Baybutt; Florian Holsboer
Inhibition of macrophage differentiation and function by cortisol.
Endocrinology 1990;127(1):476-80.
1990: K Wiedemann; Florian Holsboer
The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.
Journal of affective disorders 1990;19(2):133-7.
1990: J C Krieg; Christoph J Lauer; Leopold Hermle; U von Bardeleben; T Pollmächer; Florian Holsboer
Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results.
Neuropsychobiology 1990;23(2):57-67.
1990: K Wiedemann; Otto Benkert; Florian Holsboer
B-HT 920--a novel dopamine autoreceptor agonist in the treatment of patients with schizophrenia.
Pharmacopsychiatry 1990;23(1):50-5.
1989: U Bardeleben; Florian Holsboer
Cortisol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression.
Journal of neuroendocrinology 1989;1(6):485-8.
1989: Axel Steiger; U von Bardeleben; T Herth; Florian Holsboer
Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery.
Journal of affective disorders 1989;16(2-3):189-95.
1989: Christoph J Lauer; W Schreiber; Mathias Berger; K M Pirke; Florian Holsboer; J C Krieg
The effect of neuroendocrine secretion on brain morphology and EEG sleep in patients with eating disorders.
European archives of psychiatry and neurological sciences 1989;238(4):208-12.
1989: S Schlegel; U von Bardeleben; Klaus Wiedemann; U Frommberger; Florian Holsboer
Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression.
Psychoneuroendocrinology 1989;14(3):209-16.
1989: Florian Holsboer
Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity.
European archives of psychiatry and neurological sciences 1989;238(5-6):302-22.
1989: U von Bardeleben; Florian Holsboer; A Gerken; Otto Benkert
Mood elevating effect of fluoxetine in a diagnostically homogeneous inpatient population with major depressive disorder.
International clinical psychopharmacology 1989;4 Suppl 1():31-5.
1989: U von Bardeleben; I Heuser; Florian Holsboer
Human CRH stimulation response during acute withdrawal and after medium-term abstention from alcohol abuse.
Psychoneuroendocrinology 1989;14(6):441-9.
1989: U von Bardeleben; Axel Steiger; A Gerken; Florian Holsboer
Effects of fluoxetine upon pharmacoendocrine and sleep-EEG parameters in normal controls.
International clinical psychopharmacology 1989;4 Suppl 1():1-5.
1989: Axel Steiger; Otto Benkert; S Wöhrmann; D Steinseifer; Florian Holsboer
Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls.
Neuropsychobiology 1989;21(2):71-5.
1988: U von Bardeleben; G K Stalla; O A Müller; Florian Holsboer
Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment.
Biological psychiatry 1988;24(7):782-6.
1988: Florian Holsboer; U von Bardeleben; Axel Steiger
Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man.
Neuroendocrinology 1988;48(1):32-8.
1988: U von Bardeleben; Klaus Wiedemann; G K Stalla; O A Müller; Florian Holsboer
Exaggerated corticotrophic cell response to human corticotropin-releasing hormone in two patients during long-term carbamazepine treatment.
Biological psychiatry 1988;24(3):331-5.
1988: I Heuser; U von Bardeleben; E Boll; Florian Holsboer
Response of ACTH and cortisol to human corticotropin-releasing hormone after short-term abstention from alcohol abuse.
Biological psychiatry 1988;24(3):316-21.
1988: U von Bardeleben; Florian Holsboer
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls.
Progress in neuro-psychopharmacology & biological psychiatry 1988;12 Suppl():S165-87.
1988: Florian Holsboer
Implications of altered limbic-hypothalamic-pituitary-adrenocortical (LHPA)-function for neurobiology of depression.
Acta psychiatrica Scandinavica. Supplementum 1988;341():72-111.
1988: Florian Holsboer; G K Stalla; U von Bardeleben; K Hammann; H Müller; O A Müller
Acute adrenocortical stimulation by recombinant gamma interferon in human controls.
Life sciences 1988;42(1):1-5.
1987: Klaus Wiedemann; Florian Holsboer
Plasma dexamethasone kinetics during the DST after oral and intravenous administration of the test drug.
Biological psychiatry 1987;22(11):1340-8.
1987: Axel Steiger; Florian Holsboer; A Gerken; Lothar Demisch; Otto Benkert
Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression.
Pharmacopsychiatry 1987;20(6):262-9.
1987: Axel Steiger; T Herth; Florian Holsboer
Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls.
Acta endocrinologica 1987;116(1):36-42.
1987: Florian Holsboer; U von Bardeleben; R Buller; I Heuser; Axel Steiger
Stimulation response to corticotropin-releasing hormone (CRH) in patients with depression, alcoholism and panic disorder.
Hormone and metabolic research. Supplement series 1987;16():80-8.
1986: Florian Holsboer; K Wiedemann; E Boll
Shortened dexamethasone half-life in depressed dexamethasone nonsuppressors.
Archives of general psychiatry 1986;43(8):813-5.
1986: Florian Holsboer; A Gerken; U von Bardeleben; W Grimm; H Beyer; O A Müller; G K Stalla
Human corticotropin-releasing hormone in depression--correlation with thyrotropin secretion following thyrotropin-releasing hormone.
Biological psychiatry 1986;21(7):601-11.
1986: Florian Holsboer; M Philipp; Axel Steiger; A Gerken
Multisteroid analysis after DST in depressed patients--a controlled study.
Journal of affective disorders 1986;10(3):241-9.
1986: Florian Holsboer; Klaus Wiedemann; A Gerken; E Boll
The plasma dexamethasone variable in depression: test-retest studies and early biophase kinetics.
Psychiatry research 1986;17(2):97-103.
1985: Florian Holsboer; A Gerken; U von Bardeleben; W Grimm; G K Stalla; O A Müller
Relationship between pituitary responses to human corticotropin-releasing factor and thyrotropin-releasing hormone in depressives and normal controls.
European journal of pharmacology 1985;110(1):153-4.
1984: Florian Holsboer; A Gerken; Axel Steiger; V Fass
Mean 14.00-17.00 h plasma cortisol concentration and its relationship to the 1 mg-dexamethasone suppression response in depressives and controls.
Acta psychiatrica Scandinavica 1984;69(5):383-90.
1984: Florian Holsboer; H G Doerr; A Gerken; O A Müller; W G Sippell
Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers.
Psychiatry research 1984;11(1):15-23.
1984: Florian Holsboer; O A Müller; H G Doerr; W G Sippell; G K Stalla; A Gerken; Axel Steiger; E Boll; O Benkert
ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression.
Psychoneuroendocrinology 1984;9(2):147-60.