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Florian Holsboer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Refojo Damian; Holsboer Florian
CRH signaling.
Yehuda Rachel; Cai Guiqing; Golier Julia A; Sarapas Casey; Galea Sandro; Ising Marcus; Rein Theo; Schmeidler James; Müller-Myhsok Bertram; Holsboer Florian; Buxbaum Joseph D
Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.
Holsboer Florian
[Interview with professor Florian Holsboer (interview by Angelika Staub)]

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All Publications

2009: Refojo Damian; Holsboer Florian
CRH signaling.
Annals of the New York Academy of Sciences 2009;1179():106-19.
2009: Yehuda Rachel; Cai Guiqing; Golier Julia A; Sarapas Casey; Galea Sandro; Ising Marcus; Rein Theo; Schmeidler James; Müller-Myhsok Bertram; Holsboer Florian; Buxbaum Joseph D
Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.
Biological psychiatry 2009;66(7):708-11.
2009: Holsboer Florian
[Interview with professor Florian Holsboer (interview by Angelika Staub)]
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege / Deutsche Gesellschaft für Sozialpädiatrie und Deutsche Gesellschaft für Kinderheilkunde 2009;28(9):380-1.
2009: Ising Marcus; Lucae Susanne; Binder Elisabeth B; Bettecken Thomas; Uhr Manfred; Ripke Stephan; Kohli Martin A; Hennings Johannes M; Horstmann Sonja; Kloiber Stefan; Menke Andreas; Bondy Brigitta; Rupprecht Rainer; Domschke Katharina; Baune Bernhard T; Arolt Volker; Rush A John; Holsboer Florian; Müller-Myhsok Bertram
A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.
Archives of general psychiatry 2009;66(9):966-75.
2009: Siegmund Anja; Dahlhoff Maik; Habersetzer Ursula; Mederer Anna; Wolf Eckhard; Holsboer Florian; Wotjak Carsten T
Maternal inexperience as a risk factor of innate fear and PTSD-like symptoms in mice.
Journal of psychiatric research 2009;43(14):1156-65.
2009: Zimmermann Ulrich S; Buchmann Arlette F; Spring Constance; Uhr Manfred; Holsboer Florian; Wittchen Hans-Ulrich
Ethanol administration dampens the prolactin response to psychosocial stress exposure in sons of alcohol-dependent fathers.
Psychoneuroendocrinology 2009;34(7):996-1003.
2009: Inkster Becky; Nichols Thomas E; Saemann Philipp G; Auer Dorothee P; Holsboer Florian; Muglia Pierandrea; Matthews Paul M
Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder.
Archives of general psychiatry 2009;66(7):721-8.
2009: Rupprecht Rainer; Rammes Gerhard; Eser Daniela; Baghai Thomas C; Schüle Cornelius; Nothdurfter Caroline; Troxler Thomas; Gentsch Conrad; Kalkman Hans O; Chaperon Frederique; Uzunov Veska; McAllister Kevin H; Bertaina-Anglade Valerie; La Rochelle Christophe Drieu; Tuerck Dietrich; Floesser Annette; Kiese Beate; Schumacher Michael; Landgraf Rainer; Holsboer Florian; Kucher Klaus
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.
Science (New York, N.Y.) 2009;325(5939):490-3.
2009: Heck A; Lieb R; Ellgas A; Pfister H; Lucae S; Roeske D; Pütz B; Müller-Myhsok B; Uhr M; Holsboer F; Ising M
Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking.
Genes, brain, and behavior 2009;8(4):464-72.
2009: Schmidt Mathias V; Sterlemann Vera; Wagner Klaus; Niederleitner Bertram; Ganea Karin; Liebl Claudia; Deussing Jan M; Berger Stefan; Schütz Günther; Holsboer Florian; Müller Marianne B
Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences.
Endocrinology 2009;150(6):2709-16.
2009: Thoeringer C K; Ripke S; Unschuld P G; Lucae S; Ising M; Bettecken T; Uhr M; Keck M E; Mueller-Myhsok B; Holsboer F; Binder E B; Erhardt A
The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(6):649-57.
2009: Laenger Anna; Lang-Rollin Isabelle; Kozany Christian; Zschocke Jürgen; Zimmermann Nicole; Rüegg Joëlle; Holsboer Florian; Hausch Felix; Rein Theo
XAP2 inhibits glucocorticoid receptor activity in mammalian cells.
FEBS letters 2009;583(9):1493-8.
2009: Liberman Ana C; Druker Jimena; Refojo Damian; Holsboer Florian; Arzt Eduardo
Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1558-71.
2009: Risbrough Victoria B; Geyer Mark A; Hauger Richard L; Coste Sarah; Stenzel-Poore Mary; Wurst Wolfgang; Holsboer Florian
CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(6):1494-503.
2009: Kalus Stefanie; Kneib Thomas; Steiger Axel; Holsboer Florian; Yassouridis Alexander
A new strategy to analyze possible association structures between dynamic nocturnal hormone activities and sleep alterations in humans.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R1216-27.
2009: Künzel Heike E; Ackl Nibal; Hatzinger Martin; Held Katja; Holsboer-Trachsler Edith; Ising Marcus; Kaschka Wolfgang; Kasper Siegfried; Konstantinidis Anastasios; Sonntag Annette; Uhr Manfred; Yassouridis Alexander; Holsboer Florian; Steiger Axel
Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial.
Journal of psychiatric research 2009;43(7):702-10.
2009: Silberstein S; Vogl A M; Refojo D; Senin S A; Wurst W; Holsboer F; Deussing J M; Arzt E
Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.
Neuroscience 2009;159(2):610-7.
2009: Seemüller Florian; Riedel Michael; Obermeier Michael; Bauer Michael; Adli Mazda; Mundt Christoph; Holsboer Florian; Brieger Peter; Laux Gerd; Bender Wolfram; Heuser Isabella; Zeiler Joachim; Gaebel Wolfgang; Jäger Markus; Henkel Verena; Möller Hans-Jürgen
The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(2):181-9.
2009: Silberstein Susana; Vogl Annette M; Bonfiglio Juán José; Wurst Wolfgang; Holsboer Florian; Arzt Eduardo; Deussing Jan M; Refojo Damián
Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models.
Annals of the New York Academy of Sciences 2009;1153():120-30.
2009: Liberman Ana C; Druker Jimena; Garcia Fernando Aprile; Holsboer Florian; Arzt Eduardo
Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions.
Annals of the New York Academy of Sciences 2009;1153():6-13.
2009: Horstmann Sonja; Dose Tatjana; Lucae Susanne; Kloiber Stefan; Menke Andreas; Hennings Johannes; Spieler Derek; Uhr Manfred; Holsboer Florian; Ising Marcus
Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action.
Psychoneuroendocrinology 2009;34(2):238-48.
2009: Siegmund Anja; Kaltwasser Sebastian F; Holsboer Florian; Czisch Michael; Wotjak Carsten T
Hippocampal N-acetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice.
Biological psychiatry 2009;65(3):258-62.
2009: Hennings Johannes M; Owashi Toshimi; Binder Elisabeth B; Horstmann Sonja; Menke Andreas; Kloiber Stefan; Dose Tatjana; Wollweber Bastian; Spieler Derek; Messer Thomas; Lutz Rita; Künzel Heike; Bierner Thomas; Pollmächer Thomas; Pfister Hildegard; Nickel Thomas; Sonntag Annette; Uhr Manfred; Ising Marcus; Holsboer Florian; Lucae Susanne
Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project.
Journal of psychiatric research 2009;43(3):215-29.
2009: Erhardt A; Müller M B; Rödel A; Welt T; Ohl F; Holsboer F; Keck M E
Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775.
Journal of psychopharmacology (Oxford, England) 2009;23(1):31-9.
2009: Heck Angela; Lieb Roselind; Ellgas Andrea; Pfister Hildegard; Lucae Susanne; Erhardt Angelika; Himmerich Hubertus; Horstmann Sonja; Kloiber Stefan; Ripke Stephan; Müller-Myhsok Bertram; Bettecken Thomas; Uhr Manfred; Holsboer Florian; Ising Marcus
Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(1):104-14.
2009: Czisch Michael; Wehrle Renate; Stiegler Andrea; Peters Henning; Andrade Katia; Holsboer Florian; Sämann Philipp G
Acoustic oddball during NREM sleep: a combined EEG/fMRI study.
PloS one 2009;4(8):e6749.
2009: Chechko Natalya; Wehrle Renate; Erhardt Angelika; Holsboer Florian; Czisch Michael; Sämann Philipp G
Unstable prefrontal response to emotional conflict and activation of lower limbic structures and brainstem in remitted panic disorder.
PloS one 2009;4(5):e5537.
2009: Bunck Mirjam; Czibere Ludwig; Horvath Charlotte; Graf Cornelia; Frank Elisabeth; Kessler Melanie S; Murgatroyd Chris; Müller-Myhsok Bertram; Gonik Mariya; Weber Peter; Pütz Benno; Muigg Patrik; Panhuysen Markus; Singewald Nicolas; Bettecken Thomas; Deussing Jan M; Holsboer Florian; Spengler Dietmar; Landgraf Rainer
A hypomorphic vasopressin allele prevents anxiety-related behavior.
PloS one 2009;4(4):e5129.
2009: Touma Chadi; Fenzl Thomas; Ruschel Jörg; Palme Rupert; Holsboer Florian; Kimura Mayumi; Landgraf Rainer
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression.
PloS one 2009;4(1):e4325.
2008: Schmidt Ulrike; Holsboer Florian; Rein Theo
Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):E101; author reply E102.
2008: Lu A; Steiner M A; Whittle N; Vogl A M; Walser S M; Ableitner M; Refojo D; Ekker M; Rubenstein J L; Stalla G K; Singewald N; Holsboer F; Wotjak C T; Wurst W; Deussing J M
Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system.
Molecular psychiatry 2008;13(11):989.
2008: Wöhr Markus; Dahlhoff Maik; Wolf Eckhard; Holsboer Florian; Schwarting Rainer K W; Wotjak Carsten T
Effects of genetic background, gender, and early environmental factors on isolation-induced ultrasonic calling in mouse pups: an embryo-transfer study.
Behavior genetics 2008;38(6):579-95.
2008: Sillaber Inge; Panhuysen Markus; Henniger Markus S H; Ohl Frauke; Kühne Claudia; Pütz Benno; Pohl Thomas; Deussing Jan M; Paez-Pereda Marcelo; Holsboer Florian
Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine.
Psychopharmacology 2008;200(4):557-72.
2008: Lu A; Steiner M A; Whittle N; Vogl A M; Walser S M; Ableitner M; Refojo D; Ekker M; Rubenstein J L; Stalla G K; Singewald N; Holsboer F; Wotjak C T; Wurst W; Deussing J M
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior.
Molecular psychiatry 2008;13(11):1028-42.
2008: Hanstein R; Lu A; Wurst W; Holsboer F; Deussing J M; Clement A B; Behl C
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Neuroscience 2008;156(3):712-21.
2008: Keck Martin E; Kern Nikola; Erhardt Angelika; Unschuld Paul G; Ising Marcus; Salyakina Daria; Müller Marianne B; Knorr Carolin C; Lieb Roselind; Hohoff Christa; Krakowitzky Petra; Maier Wolfgang; Bandelow Borwin; Fritze Jürgen; Deckert Jürgen; Holsboer Florian; Müller-Myhsok Bertram; Binder Elisabeth B
Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(7):1196-204.
2008: Ströhle Andreas; Scheel Michael; Modell Sieglinde; Holsboer Florian
Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder.
Journal of psychiatric research 2008;42(14):1185-8.
2008: Friess Elisabeth; Schmid Dagmar; Modell Sieglinde; Brunner Hans; Lauer Christoph J; Holsboer Florian; Ising Marcus
Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders.
Journal of psychiatric research 2008;42(14):1154-62.
2008: Schmid Dagmar A; Brunner Hans; Lauer Christoph J; Uhr Manfred; Yassouridis Alexander; Holsboer Florian; Friess Elisabeth
Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression.
Journal of psychiatric research 2008;42(12):991-9.
2008: Reckow S; Gormanns P; Holsboer F; Turck C W
Psychiatric disorders biomarker identification: from proteomics to systems biology.
Pharmacopsychiatry 2008;41 Suppl 1():S70-7.
2008: Kronsbein Helena C; Jastorff Archana M; Maccarrone Giuseppina; Stalla Günter; Wurst Wolfgang; Holsboer Florian; Turck Christoph W; Deussing Jan M
CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells.
Molecular and cellular endocrinology 2008;292(1-2):1-10.
2008: Himmerich H; Fulda S; Linseisen J; Seiler H; Wolfram G; Himmerich S; Gedrich K; Kloiber S; Lucae S; Ising M; Uhr M; Holsboer F; Pollmächer T
Depression, comorbidities and the TNF-alpha system.
European psychiatry : the journal of the Association of European Psychiatrists 2008;23(6):421-9.
2008: Holsboer Florian
How can we realize the promise of personalized antidepressant medicines?
Nature reviews. Neuroscience 2008;9(8):638-46.
2008: Friess Elisabeth; Modell Sieglinde; Brunner Hans; Tagaya Hirokuni; Lauer Christoph J; Holsboer Florian; Ising Marcus
The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects.
European archives of psychiatry and clinical neuroscience 2008;258(5):285-91.
2008: Ambrosius Urte; Lietzenmaier Sonja; Wehrle Renate; Wichniak Adam; Kalus Stefanie; Winkelmann Juliane; Bettecken Thomas; Holsboer Florian; Yassouridis Alexander; Friess Elisabeth
Heritability of sleep electroencephalogram.
Biological psychiatry 2008;64(4):344-8.
2008: Ising Marcus; Depping Anna-Mareike; Siebertz Anna; Lucae Susanne; Unschuld Paul G; Kloiber Stefan; Horstmann Sonja; Uhr Manfred; Müller-Myhsok Bertram; Holsboer Florian
Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.
The European journal of neuroscience 2008;28(2):389-98.
2008: Menke Andreas; Lucae Susanne; Kloiber Stefan; Horstmann Sonja; Bettecken Thomas; Uhr Manfred; Ripke Stephan; Ising Marcus; Müller-Myhsok Bertram; Holsboer Florian; Binder Elisabeth B
Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation.
The American journal of psychiatry 2008;165(7):917-8.
2008: Tsolakidou A; Trümbach D; Panhuysen M; Pütz B; Deussing J; Wurst W; Sillaber I; Holsboer F; Rein T
Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways.
Molecular and cellular neurosciences 2008;38(3):444-52.
2008: Touma Chadi; Bunck Mirjam; Glasl Lisa; Nussbaumer Markus; Palme Rupert; Stein Hendrik; Wolferstätter Michael; Zeh Ramona; Zimbelmann Marina; Holsboer Florian; Landgraf Rainer
Mice selected for high versus low stress reactivity: a new animal model for affective disorders.
Psychoneuroendocrinology 2008;33(6):839-62.
2008: Steiner M A; Wanisch K; Monory K; Marsicano G; Borroni E; Bächli H; Holsboer F; Lutz B; Wotjak C T
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.
The pharmacogenomics journal 2008;8(3):196-208.
2008: Holsboer Florian; Ising Marcus
Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists.
European journal of pharmacology 2008;583(2-3):350-7.
2008: Erhardt A; Lucae S; Kern N; Unschuld P G; Ising M; Lieb R; Uhr M; Hohoff C; Deckert J; Bandelow B; Maier W; Binder E B; Müller-Myhsok B; Keck M E; Holsboer F
Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks.
Molecular psychiatry 2008;13(3):242-3.
2008: Sterlemann Vera; Ganea Karin; Liebl Claudia; Harbich Daniela; Alam Stephanie; Holsboer Florian; Müller Marianne B; Schmidt Mathias V
Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders.
Hormones and behavior 2008;53(2):386-94.
2008: Winkelmann Juliane; Lichtner Peter; Schormair Barbara; Uhr Manfred; Hauk Stephanie; Stiasny-Kolster Karin; Trenkwalder Claudia; Paulus Walter; Peglau Ines; Eisensehr Ilonka; Illig Thomas; Wichmann H-Erich; Pfister Hildegard; Golic Jelena; Bettecken Thomas; Pütz Benno; Holsboer Florian; Meitinger Thomas; Müller-Myhsok Bertram
Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome.
Movement disorders : official journal of the Movement Disorder Society 2008;23(3):350-8.
2008: Yu Shuang; Holsboer Florian; Almeida Osborne F X
Neuronal actions of glucocorticoids: focus on depression.
The Journal of steroid biochemistry and molecular biology 2008;108(3-5):300-9.
2008: Uhr Manfred; Tontsch Alina; Namendorf Christian; Ripke Stephan; Lucae Susanne; Ising Marcus; Dose Tatjana; Ebinger Martin; Rosenhagen Marcus; Kohli Martin; Kloiber Stefan; Salyakina Daria; Bettecken Thomas; Specht Michael; Pütz Benno; Binder Elisabeth B; Müller-Myhsok Bertram; Holsboer Florian
Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression.
Neuron 2008;57(2):203-9.
2008: Steiner Michel A; Marsicano Giovanni; Nestler Eric J; Holsboer Florian; Lutz Beat; Wotjak Carsten T
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
Psychoneuroendocrinology 2008;33(1):54-67.
2008: Unschuld Paul G; Ising Marcus; Erhardt Angelika; Lucae Susanne; Kohli Martin; Kloiber Stefan; Salyakina Daria; Thoeringer Christoph K; Kern Nikola; Lieb Roselind; Uhr Manfred; Binder Elisabeth B; Müller-Myhsok Bertram; Holsboer Florian; Keck Martin E
Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder.
Journal of affective disorders 2008;105(1-3):177-84.
2007: Ising Marcus; Holsboer Florian
CRH-sub-1 receptor antagonists for the treatment of depression and anxiety.
Experimental and clinical psychopharmacology 2007;15(6):519-28.
2007: Kessler Melanie S; Murgatroyd Chris; Bunck Mirjam; Czibere Ludwig; Frank Elisabeth; Jacob Wolfgang; Horvath Charlotte; Muigg Patrik; Holsboer Florian; Singewald Nicolas; Spengler Dietmar; Landgraf Rainer
Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice.
The European journal of neuroscience 2007;26(10):2857-64.
2007: Carbia-Nagashima Alberto; Gerez Juan; Perez-Castro Carolina; Paez-Pereda Marcelo; Silberstein Susana; Stalla Günter K; Holsboer Florian; Arzt Eduardo
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
Cell 2007;131(2):309-23.
2007: Thoeringer Christoph K; Binder Elisabeth B; Salyakina Daria; Erhardt Angelika; Ising Marcus; Unschuld Paul G; Kern Nikola; Lucae Susanne; Brueckl Tanja M; Mueller Marianne B; Fuchs Brigitte; Puetz Benno; Lieb Roselind; Uhr Manfred; Holsboer Florian; Mueller-Myhsok Bertram; Keck Martin E
Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks.
Journal of psychiatric research 2007;41(7):579-84.
2007: Ising Marcus; Zimmermann Ulrich S; Künzel Heike E; Uhr Manfred; Foster Alan C; Learned-Coughlin Susan M; Holsboer Florian; Grigoriadis Dimitri E
High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(9):1941-9.
2007: Reppermund Simone; Zihl Josef; Lucae Susanne; Horstmann Sonja; Kloiber Stefan; Holsboer Florian; Ising Marcus
Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation.
Biological psychiatry 2007;62(5):400-6.
2007: Winkelmann Juliane; Schormair Barbara; Lichtner Peter; Ripke Stephan; Xiong Lan; Jalilzadeh Shapour; Fulda Stephany; Pütz Benno; Eckstein Gertrud; Hauk Stephanie; Trenkwalder Claudia; Zimprich Alexander; Stiasny-Kolster Karin; Oertel Wolfgang; Bachmann Cornelius G; Paulus Walter; Peglau Ines; Eisensehr Ilonka; Montplaisir Jacques; Turecki Gustavo; Rouleau Guy; Gieger Christian; Illig Thomas; Wichmann H-Erich; Holsboer Florian; Müller-Myhsok Bertram; Meitinger Thomas
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
Nature genetics 2007;39(8):1000-6.
2007: Deussing Jan M; Kühne Claudia; Pütz Benno; Panhuysen Markus; Breu Johannes; Stenzel-Poore Mary P; Holsboer Florian; Wurst Wolfgang
Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(8):1476-95.
2007: Kloiber Stefan; Ising Marcus; Reppermund Simone; Horstmann Sonja; Dose Tatjana; Majer Matthias; Zihl Josef; Pfister Hildegard; Unschuld Paul G; Holsboer Florian; Lucae Susanne
Overweight and obesity affect treatment response in major depression.
Biological psychiatry 2007;62(4):321-6.
2007: Erhardt Angelika; Lucae Susanne; Unschuld Paul G; Ising Marcus; Kern Nikola; Salyakina Daria; Lieb Roselind; Uhr Manfred; Binder Elisabeth B; Keck Martin E; Müller-Myhsok Bertram; Holsboer Florian
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders.
Journal of affective disorders 2007;101(1-3):159-68.
2007: Thoeringer Christoph K; Sillaber Inge; Roedel Angelika; Erhardt Angelika; Mueller Marianne B; Ohl Frauke; Holsboer Florian; Keck Martin E
The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice.
Psychoneuroendocrinology 2007;32(6):746-57.
2007: Ising Marcus; Horstmann Sonja; Kloiber Stefan; Lucae Susanne; Binder Elisabeth B; Kern Nikola; Künzel Heike E; Pfennig Andrea; Uhr Manfred; Holsboer Florian
Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?
Biological psychiatry 2007;62(1):47-54.
2007: Schmidt M V; Sterlemann V; Ganea K; Liebl C; Alam S; Harbich D; Greetfeld M; Uhr M; Holsboer F; Müller M B
Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence.
Psychoneuroendocrinology 2007;32(5):417-29.
2007: Unschuld Paul G; Ising Marcus; Erhardt Angelika; Lucae Susanne; Kloiber Stefan; Kohli Martin; Salyakina Daria; Welt Tobias; Kern Nikola; Lieb Roselind; Uhr Manfred; Binder Elisabeth B; Müller-Myhsok Bertram; Holsboer Florian; Keck Martin E
Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(4):424-9.
2007: Liberman Ana C; Refojo Damian; Druker Jimena; Toscano Marta; Rein Theo; Holsboer Florian; Arzt Eduardo
The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1177-88.
2007: Vedder Helmut; Schreiber Wolfgang; Schuld Andreas; Kainz Martin; Lauer Christoph Johannes; Krieg Jürgen-Christian; Holsboer Florian; Pollmächer Thomas
Immune-endocrine host response to endotoxin in major depression.
Journal of psychiatric research 2007;41(3-4):280-9.
2007: Wehrle Renate; Kaufmann Christian; Wetter Thomas C; Holsboer Florian; Auer Dorothee P; Pollmächer Thomas; Czisch Michael
Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods.
The European journal of neuroscience 2007;25(3):863-71.
2007: Then Bergh Florian; Kümpfel Tania; Yassouridis Alexander; Lechner Christian; Holsboer Florian; Trenkwalder Claudia
Acute and chronic neuroendocrine effects of interferon-beta 1a in multiple sclerosis.
Clinical endocrinology 2007;66(2):295-303.
2007: Marsch Rudolph; Foeller Elisabeth; Rammes Gerhard; Bunck Mirjam; Kössl Manfred; Holsboer Florian; Zieglgänsberger Walter; Landgraf Rainer; Lutz Beat; Wotjak Carsten T
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(4):832-9.
2007: Himmerich Hubertus; Zimmermann Petra; Ising Marcus; Kloiber Stefan; Lucae Susanne; Kunzel Heike E; Binder Elisabeth B; Holsboer Florian; Uhr Manfred
Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment.
Neuropsychobiology 2007;55(1):28-35.
2006: Welt Tobias; Engelmann Mario; Renner Ulrich; Erhardt Angelika; Müller Marianne B; Landgraf Rainer; Holsboer Florian; Keck Martin E
Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(12):2573-9.
2006: Druker Jimena; Liberman Ana C; Acuña Matías; Giacomini Damiana; Refojo Damián; Silberstein Susana; Pereda Marcelo Paez; Stalla Günter K; Holsboer Florian; Arzt Eduardo
Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases.
Annals of the New York Academy of Sciences 2006;1088():297-306.
2006: Maccarrone Giuseppina; Kolb Nikolaus; Teplytska Larysa; Birg Isabel; Zollinger Richard; Holsboer Florian; Turck Christoph W
Phosphopeptide enrichment by IEF.
Electrophoresis 2006;27(22):4585-95.
2006: Schmidt M V; Levine S; Alam S; Harbich D; Sterlemann V; Ganea K; de Kloet E R; Holsboer F; Müller M B
Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse.
Journal of neuroendocrinology 2006;18(11):865-74.
2006: Baghai T C; Binder E B; Schule C; Salyakina D; Eser D; Lucae S; Zwanzger P; Haberger C; Zill P; Ising M; Deiml T; Uhr M; Illig T; Wichmann H-E; Modell S; Nothdurfter C; Holsboer F; Müller-Myhsok B; Möller H-J; Rupprecht R; Bondy B
Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism.
Molecular psychiatry 2006;11(11):1003-15.
2006: Erhardt Angelika; Ising Marcus; Unschuld Paul Gerson; Kern Nikola; Lucae Susanne; Pütz Benno; Uhr Manfred; Binder Elisabeth B; Holsboer Florian; Keck Martin E
Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(11):2515-22.
2006: Schmidt M V; Deussing J M; Oitzl M S; Ohl F; Levine S; Wurst W; Holsboer F; Müller M B; de Kloet E R
Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice.
The European journal of neuroscience 2006;24(8):2291-8.
2006: Roedel Angelika; Storch Corinna; Holsboer Florian; Ohl Frauke
Effects of light or dark phase testing on behavioural and cognitive performance in DBA mice.
Laboratory animals 2006;40(4):371-81.
2006: Himmerich Hubertus; Binder Elisabeth B; Künzel Heike E; Schuld Andreas; Lucae Susanne; Uhr Manfred; Pollmächer Thomas; Holsboer Florian; Ising Marcus
Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis.
Biological psychiatry 2006;60(8):882-8.
2006: Nguyen Ngoc Khoi; Keck Martin E; Hetzenauer Alfred; Thoeringer Christoph K; Wurst Wolfgang; Deussing Jan M; Holsboer Florian; Müller Marianne B; Singewald Nicolas
Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge.
Psychopharmacology 2006;188(3):374-85.
2006: Arzt Eduardo; Holsboer Florian
CRF signaling: molecular specificity for drug targeting in the CNS.
Trends in pharmacological sciences 2006;27(10):531-8.
2006: Ditzen Claudia; Jastorff Archana M; Kessler Melanie S; Bunck Mirjam; Teplytska Larysa; Erhardt Angelika; Krömer Simone A; Varadarajulu Jeeva; Targosz Bianca-Sabrina; Sayan-Ayata Eser F; Holsboer Florian; Landgraf Rainer; Turck Christoph W
Protein biomarkers in a mouse model of extremes in trait anxiety.
Molecular & cellular proteomics : MCP 2006;5(10):1914-20.
2006: Friess Elisabeth; Kuempfel Tania; Modell Sieglinde; Winkelmann Juliane; Holsboer Florian; Ising Marcus; Trenkwalder Claudia
Paroxetine treatment improves motor symptoms in patients with multiple system atrophy.
Parkinsonism & related disorders 2006;12(7):432-7.
2006: Schüssler P; Yassouridis A; Uhr M; Kluge M; Weikel J; Holsboer F; Steiger A
Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E549-56.
2006: Castillo Victor; Giacomini Damiana; Páez-Pereda Marcelo; Stalla Johanna; Labeur Marta; Theodoropoulou Marily; Holsboer Florian; Grossman Ashley B; Stalla Günter K; Arzt Eduardo
Retinoic acid as a novel medical therapy for Cushing's disease in dogs.
Endocrinology 2006;147(9):4438-44.
2006: Lucae Susanne; Salyakina Daria; Barden Nicholas; Harvey Mario; Gagné Bernard; Labbé Michel; Binder Elisabeth B; Uhr Manfred; Paez-Pereda Marcelo; Sillaber Inge; Ising Marcus; Brückl Tanja; Lieb Roselind; Holsboer Florian; Müller-Myhsok Bertram
P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.
Human molecular genetics 2006;15(16):2438-45.
2006: Schuld A; Birkmann S; Beitinger P; Haack M; Kraus T; Dalal M A; Holsboer F; Pollmächer T
Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2006;114(6):322-8.
2006: Barden Nicholas; Harvey Mario; Gagné Bernard; Shink Eric; Tremblay Monique; Raymond Catherine; Labbé Michel; Villeneuve André; Rochette Denis; Bordeleau Lise; Stadler Herbert; Holsboer Florian; Müller-Myhsok Bertram
Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006;141B(4):374-82.
2006: Müller Marianne B; Holsboer Florian
Mice with mutations in the HPA-system as models for symptoms of depression.
Biological psychiatry 2006;59(12):1104-15.
2006: Post Anke; Ackl Nibal; Rücker Monika; Schreiber Yvonne; Binder Elisabeth B; Ising Marcus; Sonntag Annette; Holsboer Florian; Almeida Osborne F X
Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression.
Biological psychiatry 2006;59(9):858-62.
2006: van Rossum Elisabeth F C; Binder Elisabeth B; Majer Matthias; Koper Jan W; Ising Marcus; Modell Sieglinde; Salyakina Daria; Lamberts Steven W J; Holsboer Florian
Polymorphisms of the glucocorticoid receptor gene and major depression.
Biological psychiatry 2006;59(8):681-8.
2006: Kaufmann C; Wehrle R; Wetter T C; Holsboer F; Auer D P; Pollmächer T; Czisch M
Brain activation and hypothalamic functional connectivity during human non-rapid eye movement sleep: an EEG/fMRI study.
Brain : a journal of neurology 2006;129(Pt 3):655-67.
2006: Ising Marcus; Holsboer Florian
Genetics of stress response and stress-related disorders.
Dialogues in clinical neuroscience 2006;8(4):433-44.
2006: Then Bergh Florian; Kümpfel Tania; Schumann Erina; Held Ulrike; Schwan Michaela; Blazevic Mirjana; Wismüller Axel; Holsboer Florian; Yassouridis Alexander; Uhr Manfred; Weber Frank; Daumer Martin; Trenkwalder Claudia; Auer Dorothee P
Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations.
BMC neurology 2006;6():19.
2006: Binder Elisabeth B; Holsboer Florian
Pharmacogenomics and antidepressant drugs.
Annals of medicine 2006;38(2):82-94.
2005: Brunner Jürgen; Bronisch Thomas; Uhr Manfred; Ising Marcus; Binder Elisabeth; Holsboer Florian; Turck Christoph W
Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters.
European archives of psychiatry and clinical neuroscience 2005;255(6):438-40.
2005: Holsboer Florian
Unipolar versus bipolar disorder: a distinction not helpful for studies of causality.
Current psychiatry reports 2005;7(6):405-7.
2005: Eisensamer Brigitte; Uhr Manfred; Meyr Sabrina; Gimpl Gerald; Deiml Tobias; Rammes Gerhard; Lambert Jeremy J; Zieglgänsberger Walter; Holsboer Florian; Rupprecht Rainer
Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(44):10198-206.
2005: Modell Sieglinde; Ising Marcus; Holsboer Florian; Lauer Christoph Johannes
The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands.
Biological psychiatry 2005;58(9):694-9.
2005: Paez-Pereda Marcelo; Giacomini Damiana; Echenique Carlos; Stalla Günter K; Holsboer Florian; Arzt Eduardo
Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs.
Current drug targets. Immune, endocrine and metabolic disorders 2005;5(3):259-67.
2005: Schumacher Johannes; Jamra Rami Abou; Becker Tim; Ohlraun Stephanie; Klopp Norman; Binder Elisabeth B; Schulze Thomas G; Deschner Monika; Schmäl Christine; Höfels Susanne; Zobel Astrid; Illig Thomas; Propping Peter; Holsboer Florian; Rietschel Marcella; Nöthen Markus M; Cichon Sven
Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression.
Biological psychiatry 2005;58(4):307-14.
2005: Crochemore C; Lu J; Wu Y; Liposits Z; Sousa N; Holsboer F; Almeida O F X
Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation.
Molecular psychiatry 2005;10(8):790-8.
2005: Holsboer Florian
The future of antidepressant pharmacogenetics is arriving. Introduction.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(6):996-8.
2005: Ising Marcus; Künzel Heike E; Binder Elisabeth B; Nickel Thomas; Modell Sieglinde; Holsboer Florian
The combined dexamethasone/CRH test as a potential surrogate marker in depression.
Progress in neuro-psychopharmacology & biological psychiatry 2005;29(6):1085-93.
2005: de Kloet E Ron; Joëls Marian; Holsboer Florian
Stress and the brain: from adaptation to disease.
Nature reviews. Neuroscience 2005;6(6):463-75.
2005: Post Anke; Ohl Frauke; Almeida Osborne F X; Binder Elisabeth B; Rücker Monika; Welt Sandra; Binder Elke; Holsboer Florian; Sillaber Inge
Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919).
Psychopharmacology 2005;180(1):150-8.
2005: Wehrle Renate; Czisch Michael; Kaufmann Christian; Wetter Thomas C; Holsboer Florian; Auer Dorothee P; Pollmächer Thomas
Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study.
Neuroreport 2005;16(8):853-7.
2005: Krömer Simone A; Kessler Melanie S; Milfay Dale; Birg Isabel N; Bunck Mirjam; Czibere Ludwig; Panhuysen Markus; Pütz Benno; Deussing Jan M; Holsboer Florian; Landgraf Rainer; Turck Christoph W
Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(17):4375-84.
2005: Refojo Damián; Echenique Carlos; Müller Marianne B; Reul Johannes M H M; Deussing Jan M; Wurst Wolfgang; Sillaber Inge; Paez-Pereda Marcelo; Holsboer Florian; Arzt Eduardo
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6183-8.
2005: Keck Martin E; Sartori Simone B; Welt Tobias; Müller Marianne B; Ohl Frauke; Holsboer Florian; Landgraf Rainer; Singewald Nicolas
Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment.
Journal of neurochemistry 2005;92(5):1170-9.
2005: Schmidt M V; Levine S; Oitzl M S; van der Mark M; Müller M B; Holsboer F; de Kloet E R
Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse.
Endocrinology 2005;146(3):1458-64.
2005: Künzel Heike E; Ising Marcus; Zobel Astrid W; Nickel Thomas; Ackl Nibal; Sonntag Annette; Holsboer Florian; Uhr Manfred
Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression.
Journal of psychiatric research 2005;39(2):173-7.
2005: Gottschalk Michaela; Kümpfel Tania; Flachenecker Peter; Uhr Manfred; Trenkwalder Claudia; Holsboer Florian; Weber Frank
Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.
Archives of neurology 2005;62(2):277-80.
2005: Pfennig Andrea; Kunzel Heike E; Kern Nikola; Ising Marcus; Majer Matthias; Fuchs Brigitte; Ernst Gertrud; Holsboer Florian; Binder Elisabeth B
Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression.
Biological psychiatry 2005;57(4):336-42.
2005: Wochnik Gabriela M; Rüegg Joëlle; Abel G Alexander; Schmidt Ulrike; Holsboer Florian; Rein Theo
FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.
The Journal of biological chemistry 2005;280(6):4609-16.
2005: Vila Greisa; Papazoglou Maria; Stalla Johanna; Theodoropoulou Marily; Stalla Günter K; Holsboer Florian; Paez-Pereda Marcelo
Sonic hedgehog regulates CRH signal transduction in the adult pituitary.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(2):281-3.
2005: Tichomirowa M A; Keck M E; Schneider H J; Paez-Pereda M; Renner U; Holsboer F; Stalla G K
Endocrine disturbances in depression.
Journal of endocrinological investigation 2005;28(1):89-99.
2005: Winkelmann J; Prager M; Lieb R; Pfister H; Spiegel B; Wittchen H-U; Holsboer F; Trenkwalder C; Ströhle A
"Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome.
Journal of neurology 2005;252(1):67-71.
2005: Ising M; Lauer C J; Holsboer F; Modell S
The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands.
Journal of psychiatric research 2005;39(1):21-8.
2005: Keck Martin E; Ohl Frauke; Holsboer Florian; Müller Marianne B
Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders.
Neuroscience and biobehavioral reviews 2005;29(4-5):867-89.
2004: Majer M; Ising M; Künzel H; Binder E B; Holsboer F; Modell S; Zihl J
Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders.
Psychological medicine 2004;34(8):1453-63.
2004: Rüegg Joëlle; Holsboer Florian; Turck Christoph; Rein Theo
Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells.
Molecular and cellular biology 2004;24(21):9371-82.
2004: Murck Harald; Held Katja; Ziegenbein Marc; Künzel Heike; Holsboer Florian; Steiger Axel
Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG.
Psychoneuroendocrinology 2004;29(9):1205-11.
2004: Wichniak Adam; Brunner Hans; Ising Marcus; Pedrosa Gil Francisco; Holsboer Florian; Friess Elisabeth
Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression.
Psychoneuroendocrinology 2004;29(9):1101-8.
2004: Murgatroyd Chris; Wigger Alexandra; Frank Elisabeth; Singewald Nicolas; Bunck Mirjam; Holsboer Florian; Landgraf Rainer; Spengler Dietmar
Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(35):7762-70.
2004: Kalisch Raffael; Salomé Nicolas; Platzer Stefan; Wigger Alexandra; Czisch Michael; Sommer Wolfgang; Singewald Nicolas; Heilig Markus; Berthele Achim; Holsboer Florian; Landgraf Rainer; Auer Dorothee P
High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats.
NeuroImage 2004;23(1):382-91.
2004: Rammes G; Eisensamer B; Ferrari U; Shapa M; Gimpl G; Gilling K; Parsons C; Riering K; Hapfelmeier G; Bondy B; Zieglgänsberger W; Holsboer F; Rupprecht R
Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner.
Molecular psychiatry 2004;9(9):846-58, 818.
2004: Oertel H; Schneider H J; Stalla G K; Holsboer F; Zihl J
The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism.
Psychoneuroendocrinology 2004;29(7):839-50.
2004: Maccarrone Giuseppina; Milfay Dale; Birg Isabel; Rosenhagen Marcus; Holsboer Florian; Grimm Rudolf; Bailey Jerome; Zolotarjova Nina; Turck Christoph W
Mining the human cerebrospinal fluid proteome by immunodepletion and shotgun mass spectrometry.
Electrophoresis 2004;25(14):2402-12.
2004: Czisch Michael; Wehrle Renate; Kaufmann Christian; Wetter Thomas C; Holsboer Florian; Pollmächer Thomas; Auer Dorothee P
Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates.
The European journal of neuroscience 2004;20(2):566-74.
2004: Zimmermann U; Spring K; Wittchen H-U; Himmerich H; Landgraf R; Uhr M; Holsboer F
Arginine vasopressin and adrenocorticotropin secretion in response to psychosocial stress is attenuated by ethanol in sons of alcohol-dependent fathers.
Journal of psychiatric research 2004;38(4):385-93.
2004: Keck Martin E; Holsboer Florian; Müller Marianne B
Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders.
Annals of the New York Academy of Sciences 2004;1018():445-57.
2004: Lauer Christoph J; Modell Sieglinde; Schreiber Wolfgang; Krieg Jürgen-Christian; Holsboer Florian
Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86.
Journal of clinical psychopharmacology 2004;24(3):356-7.
2004: Zimmermann Ulrich; Spring Konstanze; Kunz-Ebrecht Sabine Ruth; Uhr Manfred; Wittchen Hans-Ulrich; Holsboer Florian
Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(6):1156-65.
2004: Zimmerman U; Spring K; Koller G; Holsboer F; Soyka M
Hypothalamic-pituitary-adrenal system regulation in recently detoxified alcoholics is not altered by one week of treatment with acamprosate.
Pharmacopsychiatry 2004;37(3):98-102.
2004: Kovalovsky Damian; Paez Pereda Marcelo; Labeur Marta; Renner Ulrich; Holsboer Florian; Stalla Günter K; Arzt Eduardo
Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs.
FEBS letters 2004;563(1-3):229-33.
2004: Zimmermann Ulrich; Spring Konstanze; Wittchen Hans-Ulrich; Holsboer Florian
Effects of ethanol administration and induction of anxiety-related affective states on the acoustic startle reflex in sons of alcohol-dependent fathers.
Alcoholism, clinical and experimental research 2004;28(3):424-32.
2004: Held K; Künzel H; Ising M; Schmid D A; Zobel A; Murck H; Holsboer F; Steiger A
Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression.
Journal of psychiatric research 2004;38(2):129-36.
2004: Friess Elisabeth; Tagaya Hirokuni; Grethe Claus; Trachsel Lorenz; Holsboer Florian
Acute cortisol administration promotes sleep intensity in man.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(3):598-604.
2004: Wochnik Gabriela M; Young Jason C; Schmidt Ulrike; Holsboer Florian; Hartl F Ulrich; Rein Theo
Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.
FEBS letters 2004;560(1-3):35-8.
2004: Storch Corinna; Höhne Arnold; Holsboer Florian; Ohl Frauke
Activity patterns as a correlate for sleep-wake behaviour in mice.
Journal of neuroscience methods 2004;133(1-2):173-9.
2004: Müller Marianne B; Uhr Manfred; Holsboer Florian; Keck Martin E
Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice.
Neuroendocrinology 2004;79(1):1-12.
2004: Keck Martin E; Müller Marianne B; Binder Elisabeth B; Sonntag Annette; Holsboer Florian
Ziprasidone-related tardive dyskinesia.
The American journal of psychiatry 2004;161(1):175-6.
2004: Wigger Alexandra; Sánchez Mar M; Mathys Kenneth C; Ebner Karl; Frank Elisabeth; Liu Dong; Kresse Adelheid; Neumann Inga D; Holsboer Florian; Plotsky Paul M; Landgraf Rainer
Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(1):1-14.
2003: Holsboer Florian
High-quality antidepressant discovery by understanding stress hormone physiology.
Annals of the New York Academy of Sciences 2003;1007():394-404.
2003: Künzel H E; Binder E B; Nickel T; Ising M; Fuchs B; Majer M; Pfennig A; Ernst G; Kern N; Schmid D A; Uhr M; Holsboer F; Modell S
Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2169-78.
2003: Oshima Akihiko; Flachskamm Cornelia; Reul Johannes M H M; Holsboer Florian; Linthorst Astrid C E
Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2148-59.
2003: Eisensamer B; Rammes G; Gimpl G; Shapa M; Ferrari U; Hapfelmeier G; Bondy B; Parsons C; Gilling K; Zieglgänsberger W; Holsboer F; Rupprecht R
Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor.
Molecular psychiatry 2003;8(12):994-1007.
2003: Künzel Heike E; Zobel Astrid W; Nickel Thomas; Ackl Nibal; Uhr Manfred; Sonntag Annette; Ising Marcus; Holsboer Florian
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.
Journal of psychiatric research 2003;37(6):525-33.
2003: Schuld Andreas; Schmid Dagmar A; Haack Monika; Holsboer Florian; Friess Elisabeth; Pollmächer Thomas
Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone.
Journal of psychiatric research 2003;37(6):463-70.
2003: Müller Marianne B; Keck Martin E; Binder Elisabeth B; Kresse Adelheid E; Hagemeyer Thomas P; Landgraf Rainer; Holsboer Florian; Uhr Manfred
ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(11):1991-9.
2003: Uhr Manfred; Grauer Markus T; Holsboer Florian
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption.
Biological psychiatry 2003;54(8):840-6.
2003: Müller Marianne B; Zimmermann Stephan; Sillaber Inge; Hagemeyer Thomas P; Deussing Jan M; Timpl Peter; Kormann Michael S D; Droste Susanne K; Kühn Ralf; Reul Johannes M H M; Holsboer Florian; Wurst Wolfgang
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Nature neuroscience 2003;6(10):1100-7.
2003: Rosenhagen Marcus C; Soti Csaba; Schmidt Ulrike; Wochnik Gabriela M; Hartl F Ulrich; Holsboer Florian; Young Jason C; Rein Theo
The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation.
Molecular endocrinology (Baltimore, Md.) 2003;17(10):1991-2001.
2003: Herr Alexandra S; Tsolakidou Amalia F; Yassouridis Alexander; Holsboer Florian; Rein Theo
Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro.
Neuroendocrinology 2003;78(1):12-22.
2003: van Gaalen M M; Stenzel-Poore M; Holsboer F; Steckler T
Reduced attention in mice overproducing corticotropin-releasing hormone.
Behavioural brain research 2003;142(1-2):69-79.
2003: Bachmann Cornelius G; Linthorst Astrid C E; Holsboer Florian; Reul Johannes M H M
Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1056-67.
2003: Refojo Damián; Liberman Ana C; Giacomini Damiana; Carbia Nagashima Alberto; Graciarena Mariana; Echenique Carlos; Paez Pereda Marcelo; Stalla Günter; Holsboer Florian; Arzt Eduardo
Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells.
Annals of the New York Academy of Sciences 2003;992():196-204.
2003: Peñalva Rosana G; Lancel Marike; Flachskamm Cornelia; Reul Johannes M H M; Holsboer Florian; Linthorst Astrid C E
Effect of sleep and sleep deprivation on serotonergic neurotransmission in the hippocampus: a combined in vivo microdialysis/EEG study in rats.
The European journal of neuroscience 2003;17(9):1896-906.
2003: Modell Sieglinde; Huber Johannes; Holsboer Florian; Lauer Christoph J
The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolarity.
Journal of affective disorders 2003;74(2):173-84.
2003: Nickel Thomas; Sonntag Annette; Schill Julia; Zobel Astrid W; Ackl Nibal; Brunnauer Alexander; Murck Harald; Ising Marcus; Yassouridis Alexander; Steiger Axel; Zihl Josef; Holsboer Florian
Clinical and neurobiological effects of tianeptine and paroxetine in major depression.
Journal of clinical psychopharmacology 2003;23(2):155-68.
2003: Murck H; Nickel T; Künzel H; Antonijevic I A; Schill J; Zobel A; Steiger A; Sonntag A; Holsboer F
State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):348-58.
2003: Keck Martin E; Welt Tobias; Müller Marianne B; Uhr Manfred; Ohl Frauke; Wigger Alexandra; Toschi Nicola; Holsboer Florian; Landgraf Rainer
Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):235-43.
2003: Ströhle Andreas; Romeo Elena; di Michele Flavia; Pasini Augusto; Hermann Bettina; Gajewsky Gisela; Holsboer Florian; Rupprecht Rainer
Induced panic attacks shift gamma-aminobutyric acid type A receptor modulatory neuroactive steroid composition in patients with panic disorder: preliminary results.
Archives of general psychiatry 2003;60(2):161-8.
2003: Paez-Pereda Marcelo; Giacomini Damiana; Refojo Damian; Nagashima Alberto Carbia; Hopfner Ursula; Grubler Yvonne; Chervin Alberto; Goldberg Victoria; Goya Rodolfo; Hentges Shane T; Low Malcolm J; Holsboer Florian; Stalla Gunter K; Arzt Eduardo
Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1034-9.
2003: Hoffmann Anke; Ciani Elisabetta; Boeckardt Joel; Holsboer Florian; Journot Laurent; Spengler Dietmar
Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding.
Molecular and cellular biology 2003;23(3):988-1003.
2003: Schmidt Ulrike; Wochnik Gabriela M; Rosenhagen Marcus C; Young Jason C; Hartl F Ulrich; Holsboer Florian; Rein Theo
Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor.
The Journal of biological chemistry 2003;278(7):4926-31.
2003: Keck M E; Welt T; Müller M B; Landgraf R; Holsboer F
The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats.
Pharmacopsychiatry 2003;36(1):27-31.
2003: Holsboer Florian
Corticotropin-releasing hormone modulators and depression.
Current opinion in investigational drugs (London, England : 2000) 2003;4(1):46-50.
2003: Ohl Frauke; Roedel Angelika; Binder Elke; Holsboer Florian
Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice.
The European journal of neuroscience 2003;17(1):128-36.
2003: Zimmermann Ulrich; Hundt Wolfgang; Spring Konstanze; Grabner Andreas; Holsboer Florian
Hypothalamic-pituitary-adrenal system adaptation to detoxification in alcohol-dependent patients is affected by family history of alcoholism.
Biological psychiatry 2003;53(1):75-84.
2003: Mitev Y A; Darwish M; Wolf S S; Holsboer F; Almeida O F X; Patchev V K
Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection.
Neuroscience 2003;120(2):541-9.
2003: Schmidt M V; Oitzl M S; Müller M B; Ohl F; Wurst W; Holsboer F; Levine S; De Kloet E R
Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice.
Neuroscience 2003;119(2):589-95.
2002: Linthorst Astrid C E; Peñalva Rosana G; Flachskamm Cornelia; Holsboer Florian; Reul Johannes M H M
Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism.
The European journal of neuroscience 2002;16(12):2441-52.
2002: Refojo Damian; Kovalovsky Damian; Young Juan I; Rubinstein Marcelo; Holsboer Florian; Reul Johannes M H M; Low Malcolm J; Arzt Eduardo
Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice.
Journal of neuroimmunology 2002;131(1-2):126-34.
2002: Modell Sieglinde; Ising Marcus; Holsboer Florian; Lauer Christoph J
The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time.
Biological psychiatry 2002;52(5):430-7.
2002: Uhr M; Holsboer F; Müller M B
Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins.
Journal of neuroendocrinology 2002;14(9):753-9.
2002: van Gaalen M M; Reul J H M; Gesing A; Stenzel-Poore M P; Holsboer F; Steckler T
Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge.
Genes, brain, and behavior 2002;1(3):174-7.
2002: Keck M E; Welt T; Müller M B; Erhardt A; Ohl F; Toschi N; Holsboer F; Sillaber I
Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system.
Neuropharmacology 2002;43(1):101-9.
2002: Lancel Marike; Müller-Preuss Peter; Wigger Alexandra; Landgraf Rainer; Holsboer Florian
The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety.
Journal of psychiatric research 2002;36(4):197-208.
2002: Kovalovsky Damián; Refojo Damián; Liberman Ana Clara; Hochbaum Daniel; Pereda Marcelo Paez; Coso Omar A; Stalla Günter K; Holsboer Florian; Arzt Eduardo
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
Molecular endocrinology (Baltimore, Md.) 2002;16(7):1638-51.
2002: Schumann Erina M; Kümpfel Tania; Then Bergh Florian; Trenkwalder Claudia; Holsboer Florian; Auer Dorothee P
Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume.
Annals of neurology 2002;51(6):763-7.
2002: van Gaalen Marcel M; Stenzel-Poore Mary P; Holsboer Florian; Steckler Thomas
Effects of transgenic overproduction of CRH on anxiety-like behaviour.
The European journal of neuroscience 2002;15(12):2007-15.
2002: Ohl Frauke; Roedel Angelika; Storch Corinna; Holsboer Florian; Landgraf Rainer
Cognitive performance in rats differing in their inborn anxiety.
Behavioral neuroscience 2002;116(3):464-71.
2002: Abel G Alexander; Wochnik Gabriela M; Rüegg Joëlle; Rouyer Audrey; Holsboer Florian; Rein Theo
Activity of the GR in G2 and mitosis.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1352-66.
2002: Sillaber Inge; Rammes Gerhard; Zimmermann Stephan; Mahal Beatrice; Zieglgänsberger Walter; Wurst Wolfgang; Holsboer Florian; Spanagel Rainer
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
Science (New York, N.Y.) 2002;296(5569):931-3.
2002: Czisch Michael; Wetter Thomas C; Kaufmann Christian; Pollmächer Thomas; Holsboer Florian; Auer Dorothee P
Altered processing of acoustic stimuli during sleep: reduced auditory activation and visual deactivation detected by a combined fMRI/EEG study.
NeuroImage 2002;16(1):251-8.
2002: Landgrebe J; Welzl G; Metz T; van Gaalen M M; Ropers H; Wurst W; Holsboer F
Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling.
Journal of psychiatric research 2002;36(3):119-29.
2002: Müller Marianne; Holsboer Florian; Keck Martin E
Genetic modification of corticosteroid receptor signalling: novel insights into pathophysiology and treatment strategies of human affective disorders.
Neuropeptides 2002;36(2-3):117-31.
2002: Otte Christian; Kellner Michael; Arlt Josef; Jahn Holger; Holsboer Florian; Wiedemann Klaus
Prolactin but not ACTH increases during sodium lactate-induced panic attacks.
Psychiatry research 2002;109(2):201-5.
2002: Bilang-Bleuel A; Rech J; De Carli S; Holsboer F; Reul J M H M
Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat.
The European journal of neuroscience 2002;15(6):1048-60.
2002: Post Anke; Rücker Monika; Ohl Frauke; Uhr Manfred; Holsboer Florian; Almeida Osborne F X; Michaelidis Theologos M
Mechanisms underlying the protective potential of alpha-tocopherol (vitamin E) against haloperidol-associated neurotoxicity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(3):397-407.
2002: Reul Johannes M H M; Holsboer Florian
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.
Current opinion in pharmacology 2002;2(1):23-33.
2002: Muller Igaz Lionel; Refojo Damian; Costas Monica A; Holsboer Florian; Arzt Eduardo
CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death.
Biochimica et biophysica acta 2002;1542(1-3):139-48.
2002: Ströhle Andreas; Romeo Elena; di Michele Flavia; Pasini Augusto; Yassouridis Alexander; Holsboer Florian; Rupprecht Rainer
GABA(A) receptor-modulating neuroactive steroid composition in patients with panic disorder before and during paroxetine treatment.
The American journal of psychiatry 2002;159(1):145-7.
2002: Keck Martin E; Wigger Alexandra; Welt Tobias; Müller Marianne B; Gesing Angela; Reul Johannes M H M; Holsboer Florian; Landgraf Rainer; Neumann Inga D
Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(1):94-105.
2002: Peñalva R G; Flachskamm C; Zimmermann S; Wurst W; Holsboer F; Reul J M H M; Linthorst A C E
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice.
Neuroscience 2002;109(2):253-66.
2001: Müller M B; Lucassen P J; Yassouridis A; Hoogendijk W J; Holsboer F; Swaab D F
Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus.
The European journal of neuroscience 2001;14(10):1603-12.
2001: Modell S; Holsboer F
Current scientific programmes in German neurosciences: supported by official sponsors.
Pharmacopsychiatry 2001;34(6):I-VII.
2001: Rupprecht R; di Michele F; Hermann B; Ströhle A; Lancel M; Romeo E; Holsboer F
Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology.
Brain research. Brain research reviews 2001;37(1-3):59-67.
2001: Preil J; Müller M B; Gesing A; Reul J M; Sillaber I; van Gaalen M M; Landgrebe J; Holsboer F; Stenzel-Poore M; Wurst W
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2.
Endocrinology 2001;142(11):4946-55.
2001: Holsboer F
Antidepressant drug discovery in the postgenomic era.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2001;2(4):165-77.
2001: Ströhle A; Kellner M; Holsboer F; Wiedemann K
Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder.
The American journal of psychiatry 2001;158(9):1514-6.
2001: Müller M B; Preil J; Renner U; Zimmermann S; Kresse A E; Stalla G K; Keck M E; Holsboer F; Wurst W
Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation.
Endocrinology 2001;142(9):4150-3.
2001: Refojo D; Liberman A C; Holsboer F; Arzt E
Transcription factor-mediated molecular mechanisms involved in the functional cross-talk between cytokines and glucocorticoids.
Immunology and cell biology 2001;79(4):385-94.
2001: Stefferl A; Storch M K; Linington C; Stadelmann C; Lassmann H; Pohl T; Holsboer F; Tilders F J; Reul J M
Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone.
Endocrinology 2001;142(8):3616-24.
2001: Wigger A; Loerscher P; Weissenbacher P; Holsboer F; Landgraf R
Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety.
Behavior genetics 2001;31(4):371-82.
2001: Holsboer F
Prospects for antidepressant drug discovery.
Biological psychology 2001;57(1-3):47-65.
2001: Steckler T; Holsboer F
Interaction between the cholinergic system and CRH in the modulation of spatial discrimination learning in mice.
Brain research 2001;906(1-2):46-59.
2001: Gesing A; Bilang-Bleuel A; Droste S K; Linthorst A C; Holsboer F; Reul J M
Psychological stress increases hippocampal mineralocorticoid receptor levels: involvement of corticotropin-releasing hormone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(13):4822-9.
2001: Ohl F; Sillaber I; Binder E; Keck M E; Holsboer F
Differential analysis of behavior and diazepam-induced alterations in C57BL/6N and BALB/c mice using the modified hole board test.
Journal of psychiatric research 2001;35(3):147-54.
2001: Hundt W; Zimmermann U; Pöttig M; Spring K; Holsboer F
The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal.
Alcoholism, clinical and experimental research 2001;25(5):687-91.
2001: Keck M E; Holsboer F
Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders.
Peptides 2001;22(5):835-44.
2001: Then Bergh F; Kümpfel T; Grasser A; Rupprecht R; Holsboer F; Trenkwalder C
Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial.
The Journal of clinical endocrinology and metabolism 2001;86(4):1610-5.
2001: Schmidt P; Holsboer F; Spengler D
Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subunits and the phosphoinositide 3-kinase pathway.
Molecular endocrinology (Baltimore, Md.) 2001;15(4):553-64.
2001: Keck M E; Welt T; Post A; Müller M B; Toschi N; Wigger A; Landgraf R; Holsboer F; Engelmann M
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(4):337-49.
2001: Zobel A W; Nickel T; Sonntag A; Uhr M; Holsboer F; Ising M
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study.
Journal of psychiatric research 2001;35(2):83-94.
2001: Rosenhagen M C; Young J C; Wochnik G M; Herr A S; Schmidt U; Hartl F U; Holsboer F; Rein T
Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins.
Biological chemistry 2001;382(3):499-504.
2001: Steckler T; Holsboer F
Conditioned activity to amphetamine in transgenic mice expressing an antisense RNA against the glucocorticoid receptor.
Behavioral neuroscience 2001;115(1):207-19.
2001: Friess E; Kuempfel T; Winkelmann J; Schmid D; Uhr M; Rupprecht R; Holsboer F; Trenkwalder C
Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy.
Archives of neurology 2001;58(2):241-6.
2001: Steckler T; Rammes G; Sauvage M; van Gaalen M M; Weis C; Zieglgänsberger W; Holsboer F
Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice.
Journal of psychiatric research 2001;35(1):29-42.
2001: Holsboer F
Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy.
Journal of affective disorders 2001;62(1-2):77-91.
2001: Krieg J C; Lauer C J; Schreiber W; Modell S; Holsboer F
Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the 'Munich vulnerability study'.
Journal of affective disorders 2001;62(1-2):33-7.
2001: Keck M E; Welt T; Wigger A; Renner U; Engelmann M; Holsboer F; Landgraf R
The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.
The European journal of neuroscience 2001;13(2):373-80.
2001: Schuld A; Kraus T; Haack M; Hinze-Selch D; Zobel A W; Holsboer F; Pollmächer T
Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients.
Psychoneuroendocrinology 2001;26(1):65-76.
2000: Schuld A; Mullington J; Friess E; Hermann D M; Galanos C; Holsboer F; Pollmächer T
Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.
The Journal of clinical endocrinology and metabolism 2000;85(12):4624-9.
2000: Holsboer F
The stress hormone system is back on the map.
Current psychiatry reports 2000;2(6):454-6.
2000: Post A; Crochemore C; Uhr M; Holsboer F; Behl C
Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro.
The European journal of neuroscience 2000;12(12):4331-7.
2000: Sauvage M; Brabet P; Holsboer F; Bockaert J; Steckler T
Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks.
Brain research. Molecular brain research 2000;84(1-2):79-89.
2000: Müller M B; Landgraf R; Preil J; Sillaber I; Kresse A E; Keck M E; Zimmermann S; Holsboer F; Wurst W
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
Endocrinology 2000;141(11):4262-9.
2000: Holsboer F
The corticosteroid receptor hypothesis of depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;23(5):477-501.
2000: Kümpfel T; Then Bergh F; Pollmächer T; Holsboer F; Trenkwalder C
Acute effects of interferon beta-1a on plasma cytokine levels in patients with MS.
Neurology 2000;55(8):1231-3.
2000: Schuld A; Blum W F; Uhr M; Haack M; Kraus T; Holsboer F; Pollmächer T
Reduced leptin levels in human narcolepsy.
Neuroendocrinology 2000;72(4):195-8.
2000: Keck M E; Sillaber I; Ebner K; Welt T; Toschi N; Kaehler S T; Singewald N; Philippu A; Elbel G K; Wotjak C T; Holsboer F; Landgraf R; Engelmann M
Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain.
The European journal of neuroscience 2000;12(10):3713-20.
2000: Reul J M; Gesing A; Droste S; Stec I S; Weber A; Bachmann C; Bilang-Bleuel A; Holsboer F; Linthorst A C
The brain mineralocorticoid receptor: greedy for ligand, mysterious in function.
European journal of pharmacology 2000;405(1-3):235-49.
2000: Kovalovsky D; Refojo D; Holsboer F; Arzt E
Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production.
Journal of neuroimmunology 2000;109(1):23-9.
2000: Hermann B; Landgraf R; Keck M E; Wigger A; Morrow A L; Ströhle A; Holsboer F; Rupprecht R
Pharmacological characterisation of cortical gamma-aminobutyric acid type A (GABAA) receptors in two Wistar rat lines selectively bred for high and low anxiety-related behaviour.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2000;1(3):137-43.
2000: Steckler T; Sauvage M; Holsboer F
Glucocorticoid receptor impairment enhances impulsive responding in transgenic mice performing on a simultaneous visual discrimination task.
The European journal of neuroscience 2000;12(7):2559-69.
2000: Heuser I; Deuschle M; Weber B; Stalla G K; Holsboer F
Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone.
Psychoneuroendocrinology 2000;25(5):513-8.
2000: Schiffelholz T; Holsboer F; Lancel M
High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats.
Physiology & behavior 2000;69(4-5):399-404.
2000: Müller M B; Keck M E; Zimmermann S; Holsboer F; Wurst W
Disruption of feeding behavior in CRH receptor 1-deficient mice is dependent on glucocorticoids.
Neuroreport 2000;11(9):1963-6.
2000: Antonijevic I A; Murck H; Bohlhalter S; Frieboes R M; Holsboer F; Steiger A
Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men.
Neuropharmacology 2000;39(8):1474-81.
2000: Ströhle A; Pasini A; Romeo E; Hermann B; Spalletta G; di Michele F; Holsboer F; Rupprecht R
Fluoxetine decreases concentrations of 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone (THDOC) in major depression.
Journal of psychiatric research 2000;34(3):183-6.
2000: Zobel A W; Nickel T; Künzel H E; Ackl N; Sonntag A; Ising M; Holsboer F
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.
Journal of psychiatric research 2000;34(3):171-81.
2000: Keck M E; Hatzinger M; Wotjak C T; Landgraf R; Holsboer F; Neumann I D
Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats.
The European journal of neuroscience 2000;12(4):1487-94.
2000: Tagaya H; Trachsel L; Murck H; Antonijevic I; Steiger A; Holsboer F; Friess E
Temporal EEG dynamics of non-REM sleep episodes in humans.
Brain research 2000;861(2):233-40.
2000: Mullington J; Korth C; Hermann D M; Orth A; Galanos C; Holsboer F; Pollmächer T
Dose-dependent effects of endotoxin on human sleep.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(4):R947-55.
2000: Almeida O F; Condé G L; Crochemore C; Demeneix B A; Fischer D; Hassan A H; Meyer M; Holsboer F; Michaelidis T M
Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(5):779-90.
2000: Herr A S; Wochnik G M; Rosenhagen M C; Holsboer F; Rein T
Rifampicin is not an activator of glucocorticoid receptor.
Molecular pharmacology 2000;57(4):732-7.
2000: Uhr M; Steckler T; Yassouridis A; Holsboer F
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(4):380-7.
2000: Neumann I D; Wigger A; Torner L; Holsboer F; Landgraf R
Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus.
Journal of neuroendocrinology 2000;12(3):235-43.
2000: Ströhle A; Holsboer F; Rupprecht R
Increased ACTH concentrations associated with cholecystokinin tetrapeptide-induced panic attacks in patients with panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2000;22(3):251-6.
2000: Auer D P; Pütz B; Kraft E; Lipinski B; Schill J; Holsboer F
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Biological psychiatry 2000;47(4):305-13.
2000: Hatzinger M; Wotjak C T; Naruo T; Simchen R; Keck M E; Landgraf R; Holsboer F; Neumann I D
Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats.
The Journal of endocrinology 2000;164(2):197-205.
2000: Kellner M; Wiedemann K; Yassouridis A; Levengood R; Guo L S; Holsboer F; Yehuda R
Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder.
Biological psychiatry 2000;47(2):107-11.
2000: Linthorst A C; Flachskamm C; Barden N; Holsboer F; Reul J M
Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice.
The European journal of neuroscience 2000;12(1):283-91.
2000: Arzt E; Kovalovsky D; Igaz L M; Costas M; Plazas P; Refojo D; Páez-Pereda M; Reul J M; Stalla G; Holsboer F
Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action.
Annals of the New York Academy of Sciences 2000;917():672-7.
2000: Reul J M; Bilang-Bleuel A; Droste S; Linthorst A C; Holsboer F; Gesing A
New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders.
Zeitschrift für Rheumatologie 2000;59 Suppl 2():II/22-5.
1999: Kümpfel T; Then Bergh F; Friess E; Uhr M; Yassouridis A; Trenkwalder C; Holsboer F
Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis.
Neuroendocrinology 1999;70(6):431-8.
1999: Steckler T; Holsboer F
Corticotropin-releasing hormone receptor subtypes and emotion.
Biological psychiatry 1999;46(11):1480-508.
1999: Behl C; Holsboer F
The female sex hormone oestrogen as a neuroprotectant.
Trends in pharmacological sciences 1999;20(11):441-4.
1999: Stefferl A; Linington C; Holsboer F; Reul J M
Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat.
Endocrinology 1999;140(11):4932-8.
1999: Engelmann M; Ebner K; Landgraf R; Holsboer F; Wotjak1 C T
Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats.
Journal of neuroendocrinology 1999;11(11):867-72.
1999: Antonijevic I A; Murck H; Frieboes R; Holsboer F; Steiger A
On the gender differences in sleep-endocrine regulation in young normal humans.
Neuroendocrinology 1999;70(4):280-7.
1999: Then Bergh F; Kümpfel T; Trenkwalder C; Rupprecht R; Holsboer F
Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS.
Neurology 1999;53(4):772-7.
1999: Kovalovsky D; Pereda M P; Stalla G K; Holsboer F; Arzt E
Differential regulation of interleukin-1 receptor antagonist by proopiomelanocortin peptides adrenocorticotropic hormone and beta-endorphin.
Neuroimmunomodulation 1999;6(5):367-72.
1999: Rupprecht R; Holsboer F
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Trends in neurosciences 1999;22(9):410-6.
1999: Stöhr T; Almeida O F; Landgraf R; Shippenberg T S; Holsboer F; Spanagel R
Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats.
Behavioural brain research 1999;103(1):85-93.
1999: Steckler T; Holsboer F
Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function.
Behavioural brain research 1999;102(1-2):151-63.
1999: Wetzel C H; Vedder H; Holsboer F; Zieglgänsberger W; Deisz R A
Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons.
British journal of pharmacology 1999;127(4):863-8.
1999: Zobel A W; Yassouridis A; Frieboes R M; Holsboer F
Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression.
The American journal of psychiatry 1999;156(6):949-51.
1999: Landgraf R; Wigger A; Holsboer F; Neumann I D
Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour.
Journal of neuroendocrinology 1999;11(6):405-7.
1999: Holsboer F
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.
Journal of psychiatric research 1999;33(3):181-214.
1999: Then Bergh F; Grasser A; Trenkwalder C; Backmund H; Holsboer F; Rupprecht R
Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
Journal of neurology 1999;246(4):292-8.
1999: Steckler T; Weis C; Sauvage M; Mederer A; Holsboer F
Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function.
Behavioural brain research 1999;100(1-2):77-89.
1999: Schuld A; Mullington J; Hermann D; Hinze-Selch D; Fenzel T; Holsboer F; Pollmächer T
Effects of granulocyte colony-stimulating factor on night sleep in humans.
The American journal of physiology 1999;276(4 Pt 2):R1149-55.
1999: Liebsch G; Landgraf R; Engelmann M; Lörscher P; Holsboer F
Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain.
Journal of psychiatric research 1999;33(2):153-63.
1999: Ebner K; Wotjak C T; Holsboer F; Landgraf R; Engelmann M
Vasopressin released within the septal brain area during swim stress modulates the behavioural stress response in rats.
The European journal of neuroscience 1999;11(3):997-1002.
1999: Ströhle A; Kellner M; Holsboer F; Wiedemann K
Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder.
Biological psychiatry 1999;45(3):321-6.
1999: Ströhle A; Romeo E; Hermann B; Pasini A; Spalletta G; di Michele F; Holsboer F; Rupprecht R
Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery.
Biological psychiatry 1999;45(3):274-7.
1999: Perez Castro C; Peñalva R; Páez Pereda M; Renner U; Reul J M; Stalla G K; Holsboer F; Arzt E
Early activation of thyrotropin-releasing-hormone and prolactin plays a critical role during a T cell-dependent immune response.
Endocrinology 1999;140(2):690-7.
1999: Rupprecht R; Holsboer F
Neuropsychopharmacological properties of neuroactive steroids.
Steroids 1999;64(1-2):83-91.
1999: Linthorst A C; Karanth S; Barden N; Holsboer F; Reul M H
Impaired glucocorticoid receptor function evolves in aberrant physiological responses to bacterial endotoxin.
The European journal of neuroscience 1999;11(1):178-86.
1999: Lancel M; Faulhaber J; Holsboer F; Rupprecht R
The GABA(A) receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone.
Psychopharmacology 1999;141(2):213-9.
1999: Hassan A H; Patchev V K; von Rosenstiel P; Holsboer F; Almeida O F
Plasticity of hippocampal corticosteroid receptors during aging in the rat.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):115-22.
1999: Holsboer F
Neuroendocrine studies and antidepressant drug development.
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 1999;101(9):711-6.
1999: Frieboes R M; Müller U; Murck H; von Cramon D Y; Holsboer F; Steiger A
Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury.
The Journal of neuropsychiatry and clinical neurosciences 1999;11(3):354-60.
1998: Engelmann M; Landgraf R; Lörscher P; Conzelmann C; Probst J C; Holsboer F; Reul J M
Downregulation of brain mineralocorticoid and glucocorticoid receptor by antisense oligodeoxynucleotide treatment fails to alter spatial navigation in rats.
European journal of pharmacology 1998;361(1):17-26.
1998: Lauer C J; Schreiber W; Modell S; Holsboer F; Krieg J C
The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation.
Journal of psychiatric research 1998;32(6):393-401.
1998: Rupprecht R; Ströhle A; Hermann B; di Michele F; Spalletta G; Pasini A; Holsboer F; Romeo E
Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers.
Biological psychiatry 1998;44(9):912-4.
1998: Liebsch G; Linthorst A C; Neumann I D; Reul J M; Holsboer F; Landgraf R
Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):381-96.
1998: Lauer C J; von Zerssen D; Schreiber W; Modell S; Holsboer F; Krieg J C
The pre-morbid psychometric profile is stable over time in subjects at high familial risk for affective disorders.
Journal of affective disorders 1998;51(1):45-53.
1998: Post A; Holsboer F; Behl C
Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8236-46.
1998: Wiedemann K; Hirschmann M; Knaudt K; Rupprecht R; Seier F E; Holsboer F
Sleep endocrine effects of megestrol acetate in healthy men.
Journal of neuroendocrinology 1998;10(9):719-27.
1998: Wetzel C H; Hermann B; Behl C; Pestel E; Rammes G; Zieglgänsberger W; Holsboer F; Rupprecht R
Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor.
Molecular endocrinology (Baltimore, Md.) 1998;12(9):1441-51.
1998: Liebsch G; Montkowski A; Holsboer F; Landgraf R
Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour.
Behavioural brain research 1998;94(2):301-10.
1998: Wotjak C T; Ganster J; Kohl G; Holsboer F; Landgraf R; Engelmann M
Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons.
Neuroscience 1998;85(4):1209-22.
1998: Skutella T; Probst J C; Renner U; Holsboer F; Behl C
Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety.
Neuroscience 1998;85(3):795-805.
1998: Hinze-Selch D; Becker E W; Stein G M; Berg P A; Mullington J; Holsboer F; Pollmächer T
Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(2):114-22.
1998: Neumann I D; Wigger A; Liebsch G; Holsboer F; Landgraf R
Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour.
Psychoneuroendocrinology 1998;23(5):449-63.
1998: Kovalovsky D; Páez Pereda M; Sauer J; Perez Castro C; Nahmod V E; Stalla G K; Holsboer F; Arzt E
The Th1 and Th2 cytokines IFN-gamma and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: involvement of IL-1.
European journal of immunology 1998;28(7):2075-85.
1998: Sillaber I; Montkowski A; Landgraf R; Barden N; Holsboer F; Spanagel R
Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide.
Neuroscience 1998;85(2):415-25.
1998: Ströhle A; Poettig M; Barden N; Holsboer F; Montkowski A
Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction.
Neuroreport 1998;9(9):2099-102.
1998: Timpl P; Spanagel R; Sillaber I; Kresse A; Reul J M; Stalla G K; Blanquet V; Steckler T; Holsboer F; Wurst W
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nature genetics 1998;19(2):162-6.
1998: Arzt E; Páez Pereda M; Costas M; Sauer J; Renner U; Holsboer F; Stalla G K
Cytokine expression and molecular mechanisms of their auto/paracrine regulation of anterior pituitary function and growth.
Annals of the New York Academy of Sciences 1998;840():525-31.
1998: Montkowski A; Jahn H; Ströhle A; Poettig M; Holsboer F; Wiedemann K
C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats.
Brain research 1998;792(2):358-60.
1998: Ströhle A; Kellner M; Yassouridis A; Holsboer F; Wiedemann K
Effect of flumazenil in lactate-sensitive patients with panic disorder.
The American journal of psychiatry 1998;155(5):610-2.
1998: Lezoualc'h F; Sagara Y; Holsboer F; Behl C
High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(9):3224-32.
1998: Hinze-Selch D; Wetter T C; Zhang Y; Lu H C; Albert E D; Mullington J; Wekerle H; Holsboer F; Pollmächer T
In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
Neurology 1998;50(4):1149-52.
1998: Modell S; Lauer C J; Schreiber W; Huber J; Krieg J C; Holsboer F
Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;18(4):253-62.
1998: Behl C; Holsboer F
[Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection]
Fortschritte der Neurologie-Psychiatrie 1998;66(3):113-21.
1998: Ströhle A; Kellner M; Holsboer F; Wiedemann K
Atrial natriuretic hormone decreases endocrine response to a combined dexamethasone-corticotropin-releasing hormone test.
Biological psychiatry 1998;43(5):371-5.
1998: Kellner M; Knaudt K; Jahn H; Holsboer F; Wiedemann K
Atrial natriuretic hormone in lactate-induced panic attacks: mode of release and endocrine and pathophysiological consequences.
Journal of psychiatric research 1998;32(1):37-48.
1998: Wiedemann K; Lauer C J; Hirschmann M; Knaudt K; Holsboer F
Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men.
The American journal of physiology 1998;274(1 Pt 1):E139-45.
1998: Heuser I; Bissette G; Dettling M; Schweiger U; Gotthardt U; Schmider J; Lammers C H; Nemeroff C B; Holsboer F
Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment.
Depression and anxiety 1998;8(2):71-9.
1998: Hemmeter U; Rothe B; Guldner J; Holsboer F; Steiger A
Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers.
Neuropsychobiology 1998;38(1):25-31.
1997: Steiger A; Holsboer F
Neuropeptides and human sleep.
Sleep 1997;20(11):1038-52.
1997: Wiedemann K; Holsboer F
The effect of repeated human corticotropin-releasing hormone administration on dexamethasone-suppressed pituitary-adrenocortical activity in healthy subjects.
Biological psychiatry 1997;42(10):882-8.
1997: Lancel M; Mathias S; Schiffelholz T; Behl C; Holsboer F
Soluble tumor necrosis factor receptor (p75) does not attenuate the sleep changes induced by lipopolysaccharide in the rat during the dark period.
Brain research 1997;770(1-2):184-91.
1997: Guldner J; Schier T; Friess E; Colla M; Holsboer F; Steiger A
Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly.
Neurobiology of aging 1997;18(5):491-5.
1997: Barden N; Stec I S; Montkowski A; Holsboer F; Reul J M
Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor.
Neuroendocrinology 1997;66(3):212-20.
1997: Steiger A; Holsboer F
Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission.
Psychiatry research 1997;72(2):81-8.
1997: Lancel M; Faulhaber J; Schiffelholz T; Romeo E; Di Michele F; Holsboer F; Rupprecht R
Allopregnanolone affects sleep in a benzodiazepine-like fashion.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1213-8.
1997: Karanth S; Linthorst A C; Stalla G K; Barden N; Holsboer F; Reul J M
Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function.
Endocrinology 1997;138(8):3476-85.
1997: Bohlhalter S; Murck H; Holsboer F; Steiger A
Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects.
Neurobiology of aging 1997;18(4):423-9.
1997: Schöbitz B; Pezeshki G; Probst J C; Reul J M; Skutella T; Stöhr T; Holsboer F; Spanagel R
Centrally administered oligodeoxynucleotides in rats: occurrence of non-specific effects.
European journal of pharmacology 1997;331(2-3):97-107.
1997: Frieboes R M; Murck H; Wiedemann K; Holsboer F; Steiger A
Open clinical trial on the sigma ligand panamesine in patients with schizophrenia.
Psychopharmacology 1997;132(1):82-8.
1997: Montkowski A; Poettig M; Mederer A; Holsboer F
Behavioural performance in three substrains of mouse strain 129.
Brain research 1997;762(1-2):12-8.
1997: Linthorst A C; Flachskamm C; Hopkins S J; Hoadley M E; Labeur M S; Holsboer F; Reul J M
Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(11):4448-60.
1997: Behl C; Trapp T; Skutella T; Holsboer F
Protection against oxidative stress-induced neuronal cell death--a novel role for RU486.
The European journal of neuroscience 1997;9(5):912-20.
1997: Friess E; Tagaya H; Trachsel L; Holsboer F; Rupprecht R
Progesterone-induced changes in sleep in male subjects.
The American journal of physiology 1997;272(5 Pt 1):E885-91.
1997: Frieboes R M; Murck H; Schier T; Holsboer F; Steiger A
Somatostatin impairs sleep in elderly human subjects.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(5):339-45.
1997: Kellner M; Yassouridis A; Manz B; Steiger A; Holsboer F; Wiedemann K
Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?
Neuroendocrinology 1997;65(4):284-90.
1997: Behl C; Skutella T; Lezoualc'h F; Post A; Widmann M; Newton C J; Holsboer F
Neuroprotection against oxidative stress by estrogens: structure-activity relationship.
Molecular pharmacology 1997;51(4):535-41.
1997: Lauer C J; Bronisch T; Kainz M; Schreiber W; Holsboer F; Krieg J C
Pre-morbid psychometric profile of subjects at high familial risk for affective disorder.
Psychological medicine 1997;27(2):355-62.
1997: Schier T; Guldner J; Colla M; Holsboer F; Steiger A
Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration.
Journal of neuroendocrinology 1997;9(3):201-5.
1997: Modell S; Yassouridis A; Huber J; Holsboer F
Corticosteroid receptor function is decreased in depressed patients.
Neuroendocrinology 1997;65(3):216-22.
1997: Ströhle A; Jahn H; Montkowski A; Liebsch G; Boll E; Landgraf R; Holsboer F; Wiedemann K
Central and peripheral administration of atriopeptin is anxiolytic in rats.
Neuroendocrinology 1997;65(3):210-5.
1997: Reul J M; Probst J C; Skutella T; Hirschmann M; Stec I S; Montkowski A; Landgraf R; Holsboer F
Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides.
Neuroendocrinology 1997;65(3):189-99.
1997: Patchev V K; Montkowski A; Rouskova D; Koranyi L; Holsboer F; Almeida O F
Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.
The Journal of clinical investigation 1997;99(5):962-6.
1997: Montkowski A; Holsboer F
Intact spatial learning and memory in transgenic mice with reduced BDNF.
Neuroreport 1997;8(3):779-82.
1997: Skutella T; Schwarting R K; Huston J P; Sillaber I; Probst J C; Holsboer F; Spanagel R
Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour.
The European journal of neuroscience 1997;9(2):210-20.
1997: Almeida O F; Canoine V; Ali S; Holsboer F; Patchev V K
Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression.
Journal of neuroendocrinology 1997;9(2):129-34.
1997: Pollmãcher T; Hinze-Selch D; Mullington J; Fenzel T; Holsboer F
Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia.
Archives of general psychiatry 1997;54(1):89-90.
1997: Lauer C J; Schreiber W; Pollmächer T; Holsboer F; Krieg J C
Sleep in schizophrenia: a polysomnographic study on drug-naive patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1997;16(1):51-60.
1997: Behl C; Lezoualc'h F; Trapp T; Widmann M; Skutella T; Holsboer F
Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro.
Endocrinology 1997;138(1):101-6.
1996: Wotjak C T; Kubota M; Liebsch G; Montkowski A; Holsboer F; Neumann I; Landgraf R
Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion?
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(23):7725-32.
1996: Hatzinger M; Reul J M; Landgraf R; Holsboer F; Neumann I
Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging.
Neuroendocrinology 1996;64(5):349-56.
1996: Pollmächer T; Mullington J; Korth C; Schreiber W; Hermann D; Orth A; Galanos C; Holsboer F
Diurnal variations in the human host response to endotoxin.
The Journal of infectious diseases 1996;174(5):1040-5.
1996: Lezoualc'h F; Rupprecht R; Holsboer F; Behl C
Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol.
Brain research 1996;738(1):176-9.
1996: Murck H; Guldner J; Colla-Müller M; Frieboes R M; Schier T; Wiedemann K; Holsboer F; Steiger A
VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men.
The American journal of physiology 1996;271(4 Pt 2):R905-11.
1996: Lancel M; Faulhaber J; Holsboer F; Rupprecht R
Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators.
The American journal of physiology 1996;271(4 Pt 1):E763-72.
1996: Mullington J; Hermann D; Holsboer F; Pollmächer T
Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.
Neuroendocrinology 1996;64(3):233-41.
1996: Costas M; Trapp T; Pereda M P; Sauer J; Rupprecht R; Nahmod V E; Reul J M; Holsboer F; Arzt E
Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.
The Journal of clinical investigation 1996;98(6):1409-16.
1996: Hermann B; Wetzel C H; Pestel E; Zieglgänsberger W; Holsboer F; Rupprecht R
Functional antagonistic properties of clozapine at the 5-HT3 receptor.
Biochemical and biophysical research communications 1996;225(3):957-60.
1996: Páez Pereda M; Perez Castro C; Costas M; Nahmod V E; Stalla G K; Holsboer F; Arzt E
Glucocorticoids inhibit the autoregulatory induction of interleukin-1 in monocytes after endotoxin stimulation.
Neuroimmunomodulation 1996;3(4):227-32.
1996: Schreiber W; Lauer C J; Krumrey K; Holsboer F; Krieg J C
Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;15(1):7-15.
1996: Hassan A H; von Rosenstiel P; Patchev V K; Holsboer F; Almeida O F
Exacerbation of apoptosis in the dentate gyrus of the aged rat by dexamethasone and the protective role of corticosterone.
Experimental neurology 1996;140(1):43-52.
1996: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway.
Neuroscience 1996;72(4):989-97.
1996: Engelmann M; Thrivikraman K V; Su Y; Nemeroff C B; Montkowski A; Landgraf R; Holsboer F; Plotsky P M
Endocrine and behavioral effects of airpuff-startle in rats.
Psychoneuroendocrinology 1996;21(4):391-400.
1996: Rupprecht R; Berning B; Hauser C A; Holsboer F; Reul J M
Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship.
European journal of pharmacology 1996;303(3):227-34.
1996: Trapp T; Holsboer F
Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action.
Trends in pharmacological sciences 1996;17(4):145-9.
1996: Behl C; Lezoulac'h F; Widmann M; Rupprecht R; Holsboer F
Oxidative stress-resistant cells are protected against haloperidol toxicity.
Brain research 1996;717(1-2):193-5.
1996: Holsboer F; Barden N
Antidepressants and hypothalamic-pituitary-adrenocortical regulation.
Endocrine reviews 1996;17(2):187-205.
1996: Spanagel B; Stöhr T; Barden N; Holsboer F
Morphine-induced locomotor and neurochemical stimulation is enhanced in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1996;8(2):93-7.
1996: Hauser C A; Wetzel C H; Rupprecht R; Holsboer F
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Biochemical and biophysical research communications 1996;219(2):531-6.
1996: Pollmächer T; Korth C; Mullington J; Schreiber W; Sauer J; Vedder H; Galanos C; Holsboer F
Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men.
Blood 1996;87(3):900-5.
1996: Rupprecht R; Hauser C A; Trapp T; Holsboer F
Neurosteroids: molecular mechanisms of action and psychopharmacological significance.
The Journal of steroid biochemistry and molecular biology 1996;56(1-6 Spec No):163-8.
1996: Sauer J; Castren M; Hopfner U; Holsboer F; Stalla G K; Arzt E
Inhibition of lipopolysaccharide-induced monocyte interleukin-1 receptor antagonist synthesis by cortisol: involvement of the mineralocorticoid receptor.
The Journal of clinical endocrinology and metabolism 1996;81(1):73-9.
1996: Heuser I J; Schweiger U; Gotthardt U; Schmider J; Lammers C H; Dettling M; Yassouridis A; Holsboer F
Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects.
The American journal of psychiatry 1996;153(1):93-9.
1996: Sonntag A; Rothe B; Guldner J; Yassouridis A; Holsboer F; Steiger A
Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression.
Depression 1996;4(1):1-13.
1996: Hartmann A; Krumrey K; Vogl L; Dirlich G; Holsboer F; Heuser-Link M
Changes in late auditory evoked potentials induced by corticotropin-releasing hormone and corticotropin fragment 4-9 in male controls.
Neuropsychobiology 1996;33(2):90-6.
1996: Grasser A; Möller A; Backmund H; Yassouridis A; Holsboer F
Heterogeneity of hypothalamic-pituitary-adrenal system response to a combined dexamethasone-CRH test in multiple sclerosis.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104(1):31-7.
1995: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Intraperitoneal administration of bacterial endotoxin enhances noradrenergic neurotransmission in the rat preoptic area: relationship with body temperature and hypothalamic--pituitary--adrenocortical axis activity.
The European journal of neuroscience 1995;7(12):2418-30.
1995: Lammers C H; Garcia-Borreguero D; Schmider J; Gotthardt U; Dettling M; Holsboer F; Heuser I J
Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II.
Biological psychiatry 1995;38(12):803-7.
1995: Schmider J; Lammers C H; Gotthardt U; Dettling M; Holsboer F; Heuser I J
Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I.
Biological psychiatry 1995;38(12):797-802.
1995: Behl C; Rupprecht R; Skutella T; Holsboer F
Haloperidol-induced cell death--mechanism and protection with vitamin E in vitro.
Neuroreport 1995;7(1):360-4.
1995: Spanagel R; Montkowski A; Allingham K; Stöhr T; Shoaib M; Holsboer F; Landgraf R
Anxiety: a potential predictor of vulnerability to the initiation of ethanol self-administration in rats.
Psychopharmacology 1995;122(4):369-73.
1995: Paez Pereda M; Sauer J; Perez Castro C; Finkielman S; Stalla G K; Holsboer F; Arzt E
Corticotropin-releasing hormone differentially modulates the interleukin-1 system according to the level of monocyte activation by endotoxin.
Endocrinology 1995;136(12):5504-10.
1995: Guldner J; Trachsel L; Kratschmayr C; Rothe B; Holsboer F; Steiger A
Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men.
Psychopharmacology 1995;122(2):115-21.
1995: Kellner M; Holsboer F; Heuser I
Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression.
Psychiatry research 1995;59(1-2):157-60.
1995: Montkowski A; Barden N; Wotjak C; Stec I; Ganster J; Meaney M; Engelmann M; Reul J M; Landgraf R; Holsboer F
Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.
Journal of neuroendocrinology 1995;7(11):841-5.
1995: Behl C; Widmann M; Trapp T; Holsboer F
17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.
Biochemical and biophysical research communications 1995;216(2):473-82.
1995: Liebsch G; Landgraf R; Gerstberger R; Probst J C; Wotjak C T; Engelmann M; Holsboer F; Montkowski A
Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats.
Regulatory peptides 1995;59(2):229-39.
1995: Holsboer F; Lauer C J; Schreiber W; Krieg J C
Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders.
Neuroendocrinology 1995;62(4):340-7.
1995: Trapp T; Holsboer F
Ligand-induced conformational changes in the mineralocorticoid receptor analyzed by protease mapping.
Biochemical and biophysical research communications 1995;215(1):286-91.
1995: Raiden S; Polack E; Nahmod V; Labeur M; Holsboer F; Arzt E
TRH receptor on immune cells: in vitro and in vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH.
Journal of clinical immunology 1995;15(5):242-9.
1995: Kellner M; Herzog L; Yassouridis A; Holsboer F; Wiedemann K
Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic.
The American journal of psychiatry 1995;152(9):1365-7.
1995: Castrén M; Patchev V K; Almeida O F; Holsboer F; Trapp T; Castrén E
Regulation of rat mineralocorticoid receptor expression in neurons by progesterone.
Endocrinology 1995;136(9):3800-6.
1995: Seifritz E; Hemmeter U; Trachsel L; Lauer C J; Hatzinger M; Emrich H M; Holsboer F; Holsboer-Trachsler E
Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls.
Psychopharmacology 1995;120(4):449-56.
1995: Wiegers G J; Labeur M S; Stec I E; Klinkert W E; Holsboer F; Reul J M
Glucocorticoids accelerate anti-T cell receptor-induced T cell growth.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1893-902.
1995: Landgraf R; Gerstberger R; Montkowski A; Probst J C; Wotjak C T; Holsboer F; Engelmann M
V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4250-8.
1995: Labeur M S; Arzt E; Wiegers G J; Holsboer F; Reul J M
Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression.
Endocrinology 1995;136(6):2678-88.
1995: Castrén M; Trapp T; Berninger B; Castrén E; Holsboer F
Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids.
Journal of molecular endocrinology 1995;14(3):285-93.
1995: Lancel M; Crönlein J; Müller-Preuss P; Holsboer F
Lipopolysaccharide increases EEG delta activity within non-REM sleep and disrupts sleep continuity in rats.
The American journal of physiology 1995;268(5 Pt 2):R1310-8.
1995: Schöbitz B; Pezeshki G; Pohl T; Hemmann U; Heinrich P C; Holsboer F; Reul J M
Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(8):659-64.
1995: Frieboes R M; Murck H; Maier P; Schier T; Holsboer F; Steiger A
Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man.
Neuroendocrinology 1995;61(5):584-9.
1995: Gotthardt U; Schweiger U; Fahrenberg J; Lauer C J; Holsboer F; Heuser I
Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression.
The American journal of physiology 1995;268(4 Pt 2):R865-73.
1995: Landgraf R; Neumann I; Holsboer F; Pittman Q J
Interleukin-1 beta stimulates both central and peripheral release of vasopressin and oxytocin in the rat.
The European journal of neuroscience 1995;7(4):592-8.
1995: Linthorst A C; Flachskamm C; Müller-Preuss P; Holsboer F; Reul J M
Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2920-34.
1995: Teschemacher A; Zeise M L; Holsboer F; Zieglgänsberger W
The neuroactive steroid 5 alpha-tetrahydrodeoxycorticosterone increases GABAergic postsynaptic inhibition in rat neocortical neurons in vitro.
Journal of neuroendocrinology 1995;7(3):233-40.
1995: Lauer C J; Schreiber W; Holsboer F; Krieg J C
In quest of identifying vulnerability markers for psychiatric disorders by all-night polysomnography.
Archives of general psychiatry 1995;52(2):145-53.
1995: Friess E; Trachsel L; Guldner J; Schier T; Steiger A; Holsboer F
DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range.
The American journal of physiology 1995;268(1 Pt 1):E107-13.
1995: Sauer J; Polack E; Wikinski S; Holsboer F; Stalla G K; Arzt E
The glucocorticoid sensitivity of lymphocytes changes according to the activity of the hypothalamic-pituitary-adrenocortical system.
Psychoneuroendocrinology 1995;20(3):269-80.
1995: Kellner M; Herzog L; Holsboer F; Wiedemann K
Circadian changes in the sensitivity of the corticotropin-releasing hormone-stimulated HPA system after arginine vasopressin and atrial natriuretic hormone in human male controls.
Psychoneuroendocrinology 1995;20(5):515-24.
1995: Friess E; Wiedemann K; Steiger A; Holsboer F
The hypothalamic-pituitary-adrenocortical system and sleep in man.
Advances in neuroimmunology 1995;5(2):111-25.
1995: Hartmann A; Dietl T; Krumrey K; Vogl L; Dirlich G; Holsboer F; Heuser-Link M
Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls.
Peptides 1995;16(4):657-63.
1994: Trapp T; Rupprecht R; Castrén M; Reul J M; Holsboer F
Heterodimerization between mineralocorticoid and glucocorticoid receptor: a new principle of glucocorticoid action in the CNS.
Neuron 1994;13(6):1457-62.
1994: Wiegers G J; Reul J M; Holsboer F; de Kloet E R
Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro.
Endocrinology 1994;135(6):2351-7.
1994: Schweiger U; Deuschle M; Körner A; Lammers C H; Schmider J; Gotthardt U; Holsboer F; Heuser I
Low lumbar bone mineral density in patients with major depression.
The American journal of psychiatry 1994;151(11):1691-3.
1994: Reul J M; Labeur M S; Grigoriadis D E; De Souza E B; Holsboer F
Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide.
Neuroendocrinology 1994;60(5):509-19.
1994: Damm K; Rupprecht R; Holsboer F
The binary corticosteroid response: transcriptional regulation by mineralo- and glucocorticoid receptors.
Annals of the New York Academy of Sciences 1994;746():79-87; discussion 87-8.
1994: Holsboer F; Grasser A; Friess E; Wiedemann K
Steroid effects on central neurons and implications for psychiatric and neurological disorders.
Annals of the New York Academy of Sciences 1994;746():345-59; discussion 359-61.
1994: Skutella T; Criswell H; Moy S; Probst J C; Breese G R; Jirikowski G F; Holsboer F
Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat.
Neuroreport 1994;5(16):2181-5.
1994: Skutella T; Stöhr T; Probst J C; Ramalho-Ortigao F J; Holsboer F; Jirikowski G F
Antisense oligodeoxynucleotides for in vivo targeting of corticotropin-releasing hormone mRNA: comparison of phosphorothioate and 3'-inverted probe performance.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1994;26(10):460-4.
1994: Rothe B; Guldner J; Hohlfeldt E; Lauer C J; Pollmächer T; Holsboer F; Steiger A
Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1994;11(2):101-6.
1994: Skutella T; Montkowski A; Stöhr T; Probst J C; Landgraf R; Holsboer F; Jirikowski G F
Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats.
Cellular and molecular neurobiology 1994;14(5):579-88.
1994: Patchev V K; Shoaib M; Holsboer F; Almeida O F
The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus.
Neuroscience 1994;62(1):265-71.
1994: Linthorst A C; Flachskamm C; Holsboer F; Reul J M
Local administration of recombinant human interleukin-1 beta in the rat hippocampus increases serotonergic neurotransmission, hypothalamic-pituitary-adrenocortical axis activity, and body temperature.
Endocrinology 1994;135(2):520-32.
1994: Wiedemann K; Lauer C; Pollmächer T; Holsboer F
Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males.
The American journal of physiology 1994;267(1 Pt 1):E109-14.
1994: Heuser I; Yassouridis A; Holsboer F
The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.
Journal of psychiatric research 1994;28(4):341-56.
1994: Reul J M; Stec I; Wiegers G J; Labeur M S; Linthorst A C; Arzt E; Holsboer F
Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats.
The Journal of clinical investigation 1994;93(6):2600-7.
1994: Lancel M; Crönlein T A; Müller-Preuss P; Holsboer F
Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam.
Brain research 1994;646(1):85-94.
1994: Trachsel L; Schreiber W; Holsboer F; Pollmächer T
Endotoxin enhances EEG alpha and beta power in human sleep.
Sleep 1994;17(2):132-9.
1994: Heuser I J; Gotthardt U; Schweiger U; Schmider J; Lammers C H; Dettling M; Holsboer F
Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender.
Neurobiology of aging 1994;15(2):227-31.
1994: Arzt E; Sauer J; Pollmächer T; Labeur M; Holsboer F; Reul J M; Stalla G K
Glucocorticoids suppress interleukin-1 receptor antagonist synthesis following induction by endotoxin.
Endocrinology 1994;134(2):672-7.
1994: Stec I; Barden N; Reul J M; Holsboer F
Dexamethasone nonsuppression in transgenic mice expressing antisense RNA to the glucocorticoid receptor.
Journal of psychiatric research 1994;28(1):1-5.
1994: Steiger A; Guldner J; Lauer C J; Meschenmoser C; Pollmächer T; Holsboer F
Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls.
Psychopharmacology 1994;113(3-4):334-8.
1994: Steiger A; Benkert O; Holsboer F
Effects of long-term treatment with the MAO-A inhibitor moclobemide on sleep EEG and nocturnal hormonal secretion in normal men.
Neuropsychobiology 1994;30(2-3):101-5.
1993: Wiegers G J; Croiset G; Reul J M; Holsboer F; de Kloet E R
Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro.
The American journal of physiology 1993;265(6 Pt 1):E825-30.
1993: Schöbitz B; de Kloet E R; Sutanto W; Holsboer F
Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain.
The European journal of neuroscience 1993;5(11):1426-35.
1993: Rupprecht R; Reul J M; van Steensel B; Spengler D; Söder M; Berning B; Holsboer F; Damm K
Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands.
European journal of pharmacology 1993;247(2):145-54.
1993: Rupprecht R; Reul J M; Trapp T; van Steensel B; Wetzel C; Damm K; Zieglgänsberger W; Holsboer F
Progesterone receptor-mediated effects of neuroactive steroids.
Neuron 1993;11(3):523-30.
1993: Steiger A; Trachsel L; Guldner J; Hemmeter U; Rothe B; Rupprecht R; Vedder H; Holsboer F
Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation.
Brain research 1993;615(2):267-74.
1993: Reul J M; Stec I; Söder M; Holsboer F
Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.
Endocrinology 1993;133(1):312-20.
1993: Steiger A; Rupprecht R; Spengler D; Guldner J; Hemmeter U; Rothe B; Damm K; Holsboer F
Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity.
Journal of psychiatric research 1993;27(3):275-84.
1993: Schreiber W; Pollmächer T; Fassbender K; Gudewill S; Vedder H; Wiedemann K; Galanos C; Holsboer F
Endotoxin- and corticotropin-releasing hormone-induced release of ACTH and cortisol. A comparative study in men.
Neuroendocrinology 1993;58(1):123-8.
1993: Heuser I; Heuser-Link M; Gotthardt U; Grasser A; Holsboer F
Behavioral effects of a synthetic corticotropin 4-9 analog in patients with depression and patients with Alzheimer's disease.
Journal of clinical psychopharmacology 1993;13(3):171-4.
1993: Pollmächer T; Schreiber W; Gudewill S; Vedder H; Fassbender K; Wiedemann K; Trachsel L; Galanos C; Holsboer F
Influence of endotoxin on nocturnal sleep in humans.
The American journal of physiology 1993;264(6 Pt 2):R1077-83.
1993: Steiger A; Gerken A; Benkert O; Holsboer F
Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 1993;3(2):117-26.
1993: Steiger A; Holsboer F; Benkert O
Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls.
Acta psychiatrica Scandinavica 1993;87(5):358-63.
1993: Rupprecht R; Arriza J L; Spengler D; Reul J M; Evans R M; Holsboer F; Damm K
Transactivation and synergistic properties of the mineralocorticoid receptor: relationship to the glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1993;7(4):597-603.
1993: Vedder H; Weiss I; Holsboer F; Reul J M
Glucocorticoid and mineralocorticoid receptors in rat neocortical and hippocampal brain cells in culture: characterization and regulatory studies.
Brain research 1993;605(1):18-24.
1993: Steiger A; von Bardeleben U; Guldner J; Lauer C; Rothe B; Holsboer F
The sleep EEG and nocturnal hormonal secretion studies on changes during the course of depression and on effects of CNS-active drugs.
Progress in neuro-psychopharmacology & biological psychiatry 1993;17(1):125-37.
1993: Almeida O F; Hassan A H; Holsboer F
Intrahypothalamic neuroendocrine actions of corticotropin-releasing factor.
Ciba Foundation symposium 1993;172():151-69; discussion 169-72.
1993: Vedder H; Parlow F; Zieglgänsberger W; Holsboer F
Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells.
Experimental and clinical endocrinology 1993;101(3):161-5.
1992: Garcia-Borreguero D; Lauer C J; Ozdaglar A; Wiedemann K; Holsboer F; Krieg J C
Brofaromine in panic disorder: a pilot study with a new reversible inhibitor of monoamine oxidase-A.
Pharmacopsychiatry 1992;25(6):261-4.
1992: Spengler D; Rupprecht R; Van L P; Holsboer F
Identification and characterization of a 3',5'-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1931-41.
1992: Lauer C J; Krieg J C; Garcia-Borreguero D; Ozdaglar A; Holsboer F
Panic disorder and major depression: a comparative electroencephalographic sleep study.
Psychiatry research 1992;44(1):41-54.
1992: Steiger A; Guldner J; Hemmeter U; Rothe B; Wiedemann K; Holsboer F
Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls.
Neuroendocrinology 1992;56(4):566-73.
1992: Schöbitz B; Holsboer F; Kikkert R; Sutanto W; De Kloet E R
Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats.
Endocrine regulations 1992;26(3):103-9.
1992: Schreiber W; Lauer C J; Krumrey K; Holsboer F; Krieg J C
Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders.
Biological psychiatry 1992;32(1):79-90.
1992: Reul J M; Söder M; Holsboer F
The hypothalamic-pituitary-adrenocortical (HPA) system and anti-depressive drug (AD) action.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():584A-585A.
1992: Holsboer F
Serotonin and sleep regulation.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():349A-350A.
1992: Gudewill S; Pollmächer T; Vedder H; Schreiber W; Fassbender K; Holsboer F
Nocturnal plasma levels of cytokines in healthy men.
European archives of psychiatry and clinical neuroscience 1992;242(1):53-6.
1992: Holsboer F; Wiedemann K; Rupprecht R; Steiger A
Effects of corticosteroids and neurosteroids on sleep EEG.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():588A-589A.
1992: Holsboer F; Spengler D; Heuser I
The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia.
Progress in brain research 1992;93():385-417.
1992: Wiedemann K; Lauer C; Loycke A; Pollmächer T; Durst P; Machér J P; Holsboer F
Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern.
European archives of psychiatry and clinical neuroscience 1992;241(6):372-5.
1992: Heuser I J; Holsboer F
The CRH-stimulation test in affective and anxiety disorder: comparison to physical stress.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():159A-160A.
1992: Kellner M; Wiedemann K; Holsboer F
Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man.
Life sciences 1992;50(24):1835-42.
1991: Wiedemann K; von Bardeleben U; Holsboer F
Influence of human corticotropin-releasing hormone and adrenocorticotropin upon spontaneous growth hormone secretion.
Neuroendocrinology 1991;54(5):462-8.
1991: Wetzel H; von Bardeleben U; Holsboer F; Benkert O
[Zotepine versus perazine in patients with paranoid schizophrenia: a double-blind controlled trial of its effectiveness]
Fortschritte der Neurologie-Psychiatrie 1991;59 Suppl 1():23-9.
1991: Steiger A; Guldner J; Knisatschek H; Rothe B; Lauer C; Holsboer F
Effects of an ACTH/MSH(4-9) analog (HOE 427) on the sleep EEG and nocturnal hormonal secretion in humans.
Peptides 1991;12(5):1007-10.
1991: Heuser I J; Wark H J; Keul J; Holsboer F
Hypothalamic-pituitary-adrenal axis function in elderly endurance athletes.
The Journal of clinical endocrinology and metabolism 1991;73(3):485-8.
1991: von Bardeleben U; Holsboer F
Effect of age on the cortisol response to human corticotropin-releasing hormone in depressed patients pretreated with dexamethasone.
Biological psychiatry 1991;29(10):1042-50.
1991: Wiegand M; Möller A A; Schreiber W; Krieg J C; Holsboer F
Alterations of nocturnal sleep in patients with HIV infection.
Acta neurologica Scandinavica 1991;83(2):141-2.
1991: Heuser I J; Holsboer F
Research activity at the Max Planck Institute for Psychiatry (Munich): depression in later life.
International psychogeriatrics / IPA 1991;3(1):75-8.
1991: Wiegand M; Möller A A; Schreiber W; Krieg J C; Fuchs D; Wachter H; Holsboer F
Nocturnal sleep EEG in patients with HIV infection.
European archives of psychiatry and clinical neuroscience 1991;240(3):153-8.
1991: Steiger A; von Bardeleben U; Wiedemann K; Holsboer F
Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission.
Journal of psychiatric research 1991;25(4):169-77.
1991: Wetzel H; Wiedemann K; Holsboer F; Benkert O
Savoxepine: invalidation of an "atypical" neuroleptic response pattern predicted by animal models in an open clinical trial with schizophrenic patients.
Psychopharmacology 1991;103(2):280-3.
1990: Baybutt H N; Holsboer F
Inhibition of macrophage differentiation and function by cortisol.
Endocrinology 1990;127(1):476-80.
1990: Wiedemann K; Holsboer F
The effect of dexamethasone dosage upon plasma cortisol and dexamethasone during the DST.
Journal of affective disorders 1990;19(2):133-7.
1990: Wiedemann K; Benkert O; Holsboer F
B-HT 920--a novel dopamine autoreceptor agonist in the treatment of patients with schizophrenia.
Pharmacopsychiatry 1990;23(1):50-5.
1990: Krieg J C; Lauer C J; Hermle L; von Bardeleben U; Pollmächer T; Holsboer F
Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results.
Neuropsychobiology 1990;23(2):57-67.
1989: Bardeleben U; Holsboer F
Cortisol response to a combined dexamethasone-human corticotrophin-releasing hormone challenge in patients with depression.
Journal of neuroendocrinology 1989;1(6):485-8.
1989: Steiger A; von Bardeleben U; Herth T; Holsboer F
Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery.
Journal of affective disorders 1989;16(2-3):189-95.
1989: von Bardeleben U; Holsboer F; Gerken A; Benkert O
Mood elevating effect of fluoxetine in a diagnostically homogeneous inpatient population with major depressive disorder.
International clinical psychopharmacology 1989;4 Suppl 1():31-5.
1989: von Bardeleben U; Steiger A; Gerken A; Holsboer F
Effects of fluoxetine upon pharmacoendocrine and sleep-EEG parameters in normal controls.
International clinical psychopharmacology 1989;4 Suppl 1():1-5.
1989: Lauer C; Schreiber W; Berger M; Pirke K M; Holsboer F; Krieg J C
The effect of neuroendocrine secretion on brain morphology and EEG sleep in patients with eating disorders.
European archives of psychiatry and neurological sciences 1989;238(4):208-12.
1989: Schlegel S; von Bardeleben U; Wiedemann K; Frommberger U; Holsboer F
Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression.
Psychoneuroendocrinology 1989;14(3):209-16.
1989: Holsboer F
Psychiatric implications of altered limbic-hypothalamic-pituitary-adrenocortical activity.
European archives of psychiatry and neurological sciences 1989;238(5-6):302-22.
1989: von Bardeleben U; Heuser I; Holsboer F
Human CRH stimulation response during acute withdrawal and after medium-term abstention from alcohol abuse.
Psychoneuroendocrinology 1989;14(6):441-9.
1989: Steiger A; Benkert O; Wöhrmann S; Steinseifer D; Holsboer F
Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls.
Neuropsychobiology 1989;21(2):71-5.
1988: von Bardeleben U; Stalla G K; Müller O A; Holsboer F
Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment.
Biological psychiatry 1988;24(7):782-6.
1988: Holsboer F; von Bardeleben U; Steiger A
Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man.
Neuroendocrinology 1988;48(1):32-8.
1988: von Bardeleben U; Wiedemann K; Stalla G K; Müller O A; Holsboer F
Exaggerated corticotrophic cell response to human corticotropin-releasing hormone in two patients during long-term carbamazepine treatment.
Biological psychiatry 1988;24(3):331-5.
1988: Heuser I; von Bardeleben U; Boll E; Holsboer F
Response of ACTH and cortisol to human corticotropin-releasing hormone after short-term abstention from alcohol abuse.
Biological psychiatry 1988;24(3):316-21.
1988: von Bardeleben U; Holsboer F
Human corticotropin releasing hormone: clinical studies in patients with affective disorders, alcoholism, panic disorder and in normal controls.
Progress in neuro-psychopharmacology & biological psychiatry 1988;12 Suppl():S165-87.
1988: Holsboer F
Implications of altered limbic-hypothalamic-pituitary-adrenocortical (LHPA)-function for neurobiology of depression.
Acta psychiatrica Scandinavica. Supplementum 1988;341():72-111.
1988: Holsboer F; Stalla G K; von Bardeleben U; Hammann K; Müller H; Müller O A
Acute adrenocortical stimulation by recombinant gamma interferon in human controls.
Life sciences 1988;42(1):1-5.
1987: Wiedemann K; Holsboer F
Plasma dexamethasone kinetics during the DST after oral and intravenous administration of the test drug.
Biological psychiatry 1987;22(11):1340-8.
1987: Steiger A; Holsboer F; Gerken A; Demisch L; Benkert O
Results of an open clinical trial of brofaromine (CGP 11 305 A), a competitive, selective, and short-acting inhibitor of MAO-A in major endogenous depression.
Pharmacopsychiatry 1987;20(6):262-9.
1987: Steiger A; Herth T; Holsboer F
Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls.
Acta endocrinologica 1987;116(1):36-42.
1987: Holsboer F; von Bardeleben U; Buller R; Heuser I; Steiger A
Stimulation response to corticotropin-releasing hormone (CRH) in patients with depression, alcoholism and panic disorder.
Hormone and metabolic research. Supplement series 1987;16():80-8.
1986: Holsboer F; Wiedemann K; Boll E
Shortened dexamethasone half-life in depressed dexamethasone nonsuppressors.
Archives of general psychiatry 1986;43(8):813-5.
1986: Holsboer F; Gerken A; von Bardeleben U; Grimm W; Beyer H; Müller O A; Stalla G K
Human corticotropin-releasing hormone in depression--correlation with thyrotropin secretion following thyrotropin-releasing hormone.
Biological psychiatry 1986;21(7):601-11.
1986: Holsboer F; Philipp M; Steiger A; Gerken A
Multisteroid analysis after DST in depressed patients--a controlled study.
Journal of affective disorders 1986;10(3):241-9.
1986: Holsboer F; Wiedemann K; Gerken A; Boll E
The plasma dexamethasone variable in depression: test-retest studies and early biophase kinetics.
Psychiatry research 1986;17(2):97-103.
1985: Holsboer F; Gerken A; von Bardeleben U; Grimm W; Stalla G K; Müller O A
Relationship between pituitary responses to human corticotropin-releasing factor and thyrotropin-releasing hormone in depressives and normal controls.
European journal of pharmacology 1985;110(1):153-4.
1984: Holsboer F; Gerken A; Steiger A; Fass V
Mean 14.00-17.00 h plasma cortisol concentration and its relationship to the 1 mg-dexamethasone suppression response in depressives and controls.
Acta psychiatrica Scandinavica 1984;69(5):383-90.
1984: Holsboer F; Doerr H G; Gerken A; Müller O A; Sippell W G
Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers.
Psychiatry research 1984;11(1):15-23.
1984: Holsboer F; Müller O A; Doerr H G; Sippell W G; Stalla G K; Gerken A; Steiger A; Boll E; Benkert O
ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression.
Psychoneuroendocrinology 1984;9(2):147-60.

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