Jens Holst

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Müssig Karsten; Staiger Harald; Machicao Fausto; Machann Jürgen; Schick Fritz; Schäfer Silke A; Claussen Claus D; Holst Jens J; Gallwitz Baptist; Stefan Norbert; Fritsche Andreas; Häring Hans-Ulrich
Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.
Liu Xiaowen; Murali Sangita G; Holst Jens J; Ney Denise M
Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats.
Koopmann Matthew C; Liu Xiaowen; Boehler Christopher J; Murali Sangita G; Holst Jens J; Ney Denise M
Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome.

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2009: Müssig Karsten; Staiger Harald; Machicao Fausto; Machann Jürgen; Schick Fritz; Schäfer Silke A; Claussen Claus D; Holst Jens J; Gallwitz Baptist; Stefan Norbert; Fritsche Andreas; Häring Hans-Ulrich
Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.
Metabolism: clinical and experimental 2009;58(12):1809-11.
2009: Liu Xiaowen; Murali Sangita G; Holst Jens J; Ney Denise M
Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(5):R1554-62.
2009: Koopmann Matthew C; Liu Xiaowen; Boehler Christopher J; Murali Sangita G; Holst Jens J; Ney Denise M
Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome.
JPEN. Journal of parenteral and enteral nutrition 2009;33(6):629-38; discussion 638-9.
2009: Henriksen Dennis B; Alexandersen Peter; Hartmann Bolette; Adrian Charlotte L; Byrjalsen Inger; Bone Henry G; Holst Jens J; Christiansen Claus
Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD.
Bone 2009;45(5):833-42.
2009: Le Gall Maud; Gallois Mélanie; Sève Bernard; Louveau Isabelle; Holst Jens J; Oswald Isabelle P; Lallès Jean-Paul; Guilloteau Paul
Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets.
The British journal of nutrition 2009;102(9):1285-96.
2009: Gelling Richard W; Vuguin Patricia M; Du Xiu Quan; Cui Lingguang; Rømer John; Pederson Raymond A; Leiser Margarita; Sørensen Heidi; Holst Jens J; Fledelius Christian; Johansen Peter B; Fleischer Norman; McIntosh Christopher H S; Nishimura Erica; Charron Maureen J
Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E695-707.
2009: Patti Mary-Elizabeth; Houten Sander M; Bianco Antonio C; Bernier Raquel; Larsen P Reed; Holst Jens J; Badman Michael K; Maratos-Flier Eleftheria; Mun Edward C; Pihlajamaki Jussi; Auwerx Johan; Goldfine Allison B
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Obesity (Silver Spring, Md.) 2009;17(9):1671-7.
2009: Vilsbøll Tina; Holst Jens J; Knop Filip K
The spectrum of antidiabetic actions of GLP-1 in patients with diabetes.
Best practice & research. Clinical endocrinology & metabolism 2009;23(4):453-62.
2009: Deacon Carolyn F; Holst Jens J
Immunoassays for the incretin hormones GIP and GLP-1.
Best practice & research. Clinical endocrinology & metabolism 2009;23(4):425-32.
2009: Christensen Mikkel; Knop Filip K; Holst Jens J; Vilsboll Tina
Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus.
IDrugs : the investigational drugs journal 2009;12(8):503-13.
2009: Bonuccelli Sandra; Muscelli Elza; Gastaldelli Amalia; Barsotti Elisabetta; Astiarraga Brenno D; Holst Jens J; Mari Andrea; Ferrannini Ele
Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E532-7.
2009: Schrader Henning; Menge Bjoern A; Breuer Thomas G K; Ritter Peter R; Uhl Waldemar; Schmidt Wolfgang E; Holst Jens J; Meier Juris J
Impaired glucose-induced glucagon suppression after partial pancreatectomy.
The Journal of clinical endocrinology and metabolism 2009;94(8):2857-63.
2009: Mortensen Lene S; Hartvigsen Merete L; Brader Lea J; Astrup Arne; Schrezenmeir Jürgen; Holst Jens J; Thomsen Claus; Hermansen Kjeld
Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein.
The American journal of clinical nutrition 2009;90(1):41-8.
2009: Müssig Karsten; Staiger Harald; Machicao Fausto; Kirchhoff Kerstin; Guthoff Martina; Schäfer Silke A; Kantartzis Konstantinos; Silbernagel Günther; Stefan Norbert; Holst Jens J; Gallwitz Baptist; Häring Hans-Ulrich; Fritsche Andreas
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.
Diabetes 2009;58(7):1715-20.
2009: Bosch Guido; Verbrugghe Adronie; Hesta Myriam; Holst Jens J; van der Poel Antonius F B; Janssens Geert P J; Hendriks Wouter H
The effects of dietary fibre type on satiety-related hormones and voluntary food intake in dogs.
The British journal of nutrition 2009;102(2):318-25.
2009: Holst Birgitte; Egerod Kristoffer L; Jin Chunyu; Petersen Pia Steen; Østergaard Mette Viberg; Hald Jacob; Sprinkel A M Ejernaes; Størling Joachim; Mandrup-Poulsen Thomas; Holst Jens J; Thams Peter; Orskov Cathrine; Wierup Nils; Sundler Frank; Madsen Ole D; Schwartz Thue W
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Endocrinology 2009;150(6):2577-85.
2009: Sloth Birgitte; Due Anette; Larsen Thomas M; Holst Jens J; Heding Anders; Astrup Arne
The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period.
The British journal of nutrition 2009;101(12):1846-58.
2009: Deacon Carolyn F; Holst Jens J
Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Advances in therapy 2009;26(5):488-99.
2009: Vollmer Kirsten; Gardiwal Husai; Menge Bjoern A; Goetze Oliver; Deacon Carolyn F; Schmidt Wolfgang E; Holst Jens J; Meier Juris J
Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans.
The Journal of clinical endocrinology and metabolism 2009;94(4):1379-85.
2009: Kaji Tatsuru; Tanaka Hiroaki; Redstone Heather; Wallace Laurie E; Holst Jens J; Sigalet David L
Temporal changes in the intestinal growth promoting effects of glucagon-like peptide 2 following intestinal resection.
The Journal of surgical research 2009;152(2):271-80.
2009: Hlebowicz Joanna; Hlebowicz Anna; Lindstedt Sandra; Björgell Ola; Höglund Peter; Holst Jens J; Darwiche Gassan; Almér Lars-Olof
Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects.
The American journal of clinical nutrition 2009;89(3):815-21.
2009: Enç Feruze Yilmaz; Ones Tunç; Akin H Levent; Dede Fuat; Turoglu H Turgut; Ulfer Gözde; Bekiroglu Nural; Haklar Goncagül; Rehfeld Jens F; Holst Jens J; Ulusoy Nefise B; Imeryüz Nese
Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G482-9.
2009: Faerch Kristine; Vaag Allan; Holst Jens J; Hansen Torben; Jørgensen Torben; Borch-Johnsen Knut
Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study.
Diabetes care 2009;32(3):439-44.
2009: Olesen Stine Chabert; Hansen Dorte Lindqvist; Almdal Thomas; Bendtsen Flemming; Nordgaard Inge; Hvolris Lisbeth Edvardsen; Holst Jens J; Naver Lars; Madsbad Sten
[Surgical treatment of diabetes mellitus type 2]
Ugeskrift for laeger 2009;171(8):615-7.
2009: Knop Filip K; Vilsbøll Tina; Holst Jens J
Incretin-based therapy of type 2 diabetes mellitus.
Current protein & peptide science 2009;10(1):46-55.
2009: Greenfield Jerry R; Farooqi I Sadaf; Keogh Julia M; Henning Elana; Habib Abdella M; Blackwood Anthea; Reimann Frank; Holst Jens J; Gribble Fiona M
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.
The American journal of clinical nutrition 2009;89(1):106-13.
2008: Liu Xiaowen; Murali Sangita G; Holst Jens J; Ney Denise M
Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(6):R1794-802.
2008: Kaji Tatsuru; Tanaka Hiroaki; Holst Jens J; Redstone Heather; Wallace Laurie; de Heuval Elaine; Sigalet David L
The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat.
European journal of pharmacology 2008;596(1-3):138-45.
2008: Ellrichmann Mark; Kapelle Mario; Ritter Peter R; Holst Jens J; Herzig Karl-Heinz; Schmidt Wolfgang E; Schmitz Frank; Meier Juris J
Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations.
The Journal of clinical endocrinology and metabolism 2008;93(10):3995-8.
2008: Müssig Karsten; Oncü Arzu; Lindauer Philipp; Heininger Alexandra; Aebert Hermann; Unertl Klaus; Ziemer Gerhard; Häring Hans-Ulrich; Holst Jens J; Gallwitz Baptist
Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes.
The American journal of cardiology 2008;102(5):646-7.
2008: Knop Filip K; Holst Jens J; Vilsbøll Tina
Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility.
IDrugs : the investigational drugs journal 2008;11(7):497-501.
2008: Madsbad Sten; Krarup Thure; Deacon Carolyn F; Holst Jens J
Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials.
Current opinion in clinical nutrition and metabolic care 2008;11(4):491-9.
2008: Robertson Marli A; Sigalet David L; Holst Jens J; Meddings Jon B; Wood Julie; Sharkey Keith A
Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study.
Journal of autism and developmental disorders 2008;38(6):1066-71.
2008: Sørensen Lone B; Cueto Heidi T; Andersen Maja T; Bitz Christian; Holst Jens J; Rehfeld Jens F; Astrup Arne
The effect of salatrim, a low-calorie modified triacylglycerol, on appetite and energy intake.
The American journal of clinical nutrition 2008;87(5):1163-9.
2008: Koopmann Matthew C; Nelson David W; Murali Sangita G; Liu Xiaowen; Brownfield Mark S; Holst Jens J; Ney Denise M
Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats.
JPEN. Journal of parenteral and enteral nutrition 2008;32(3):254-65.
2008: Muscelli Elza; Mari Andrea; Casolaro Arturo; Camastra Stefania; Seghieri Giuseppe; Gastaldelli Amalia; Holst Jens J; Ferrannini Ele
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients.
Diabetes 2008;57(5):1340-8.
2008: Due Anette; Larsen Thomas M; Hermansen Kjeld; Stender Steen; Holst Jens J; Toubro Søren; Martinussen Torben; Astrup Arne
Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets.
The American journal of clinical nutrition 2008;87(4):855-62.
2008: Nilsson Anne C; Ostman Elin M; Holst Jens J; Björck Inger M E
Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.
The Journal of nutrition 2008;138(4):732-9.
2008: Holst Jens J; Deacon Carolyn F; Vilsbøll Tina; Krarup Thure; Madsbad Sten
Glucagon-like peptide-1, glucose homeostasis and diabetes.
Trends in molecular medicine 2008;14(4):161-8.
2008: Nelson David W; Murali Sangita G; Liu Xiaowen; Koopmann Matthew C; Holst Jens J; Ney Denise M
Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1175-84.
2008: Pedersen-Bjergaard Ulrik; Thomsen Carsten E; Høgenhaven Hans; Smed Annelise; Kjaer Troels W; Holst Jens J; Dela Flemming; Hilsted Linda; Frandsen Erik; Pramming Stig; Thorsteinsson Birger
Angiotensin-converting enzyme activity and cognitive impairment during hypoglycaemia in healthy humans.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2008;9(1):37-48.
2008: Laakso M; Zilinskaite J; Hansen T; Boesgaard T Welløv; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst J J; Kuulasmaa T; Hribal M L; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U;
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Diabetologia 2008;51(3):502-11.
2008: Vollmer Kirsten; Holst Jens J; Baller Birgit; Ellrichmann Mark; Nauck Michael A; Schmidt Wolfgang E; Meier Juris J
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance.
Diabetes 2008;57(3):678-87.
2008: Pedersen Nis B; Hjollund Karina R; Johnsen Anders H; Orskov Cathrine; Rosenkilde Mette M; Hartmann Bolette; Holst Jens J
Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects.
Regulatory peptides 2008;146(1-3):310-20.
2008: Azuma Koichiro; Rádiková Zofia; Mancino Juliet; Toledo Frederico G S; Thomas Ernestine; Kangani Cyrous; Dalla Man Chiara; Cobelli Claudio; Holst Jens J; Deacon Carolyn F; He Yanling; Ligueros-Saylan Monica; Serra Denise; Foley James E; Kelley David E
Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2008;93(2):459-64.
2008: Lerche Susanne; Brock Birgitte; Rungby Jørgen; Bøtker Hans E; Møller Niels; Rodell Anders; Bibby Bo Martin; Holst Jens J; Schmitz Ole; Gjedde Albert
Glucagon-like peptide-1 inhibits blood-brain glucose transfer in humans.
Diabetes 2008;57(2):325-31.
2008: Dynesen Anja W; Bardow Allan; Astrup Arne; Petersson Birgit; Holst Jens J; Nauntofte Birgitte
Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa.
The American journal of clinical nutrition 2008;87(1):12-22.
2008: Amin Harish; Holst Jens J; Hartmann Bolette; Wallace Laurie; Wright Jim; Sigalet David L
Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate.
Pediatrics 2008;121(1):e180-6.
2008: Pereira-Fantini Prue M; Nagy Eva S; Thomas Sarah L; Taylor Russell G; Sourial Magdy; Paris Monique C J; Holst Jens J; Fuller Peter J; Bines Julie E
GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome.
Journal of pediatric gastroenterology and nutrition 2008;46(1):20-8.
2008: Rosenstock Julio; Foley James E; Rendell Marc; Landin-Olsson Mona; Holst Jens J; Deacon Carolyn F; Rochotte Erika; Baron Michelle A
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.
Diabetes care 2008;31(1):30-5.
2008: Utzschneider Kristina M; Tong Jenny; Montgomery Brenda; Udayasankar Jayalakshmi; Gerchman Fernando; Marcovina Santica M; Watson Catherine E; Ligueros-Saylan Monica A; Foley James E; Holst Jens J; Deacon Carolyn F; Kahn Steven E
The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose.
Diabetes care 2008;31(1):108-13.
2008: Gottschalck Ida B; Jeppesen Palle B; Hartmann Bolette; Holst Jens J; Henriksen Dennis B
Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome.
Scandinavian journal of gastroenterology 2008;43(11):1304-10.
2008: Deacon Carolyn F; Carr Richard D; Holst Jens J
DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes.
Frontiers in bioscience : a journal and virtual library 2008;13():1780-94.
2007: Sangild Per T; Malo Christiane; Schmidt Mette; Petersen Yvette M; Elnif Jan; Holst Jens J; Buddington Randal K
Glucagon-like peptide 2 has limited efficacy to increase nutrient absorption in fetal and preterm pigs.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(6):R2179-84.
2007: McClean Paula L; Irwin Nigel; Cassidy Roslyn S; Holst Jens J; Gault Victor A; Flatt Peter R
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1746-55.
2007: Knop Filip K; Vilsbøll Tina; Højberg Patricia V; Larsen Steen; Madsbad Sten; Holst Jens J; Krarup Thure
The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Regulatory peptides 2007;144(1-3):123-30.
2007: El-Ouaghlidi Andrea; Rehring Erika; Holst Jens J; Schweizer Anja; Foley James; Holmes David; Nauck Michael A
The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion.
The Journal of clinical endocrinology and metabolism 2007;92(11):4165-71.
2007: Teng Min; Johnson Michael D; Thomas Christine; Kiel Dan; Lakis James N; Kercher Tim; Aytes Shelley; Kostrowicki Jarek; Bhumralkar Dilip; Truesdale Larry; May John; Sidelman Ulla; Kodra Janos T; Jørgensen Anker Steen; Olesen Preben Houlberg; de Jong Johannes Cornelis; Madsen Peter; Behrens Carsten; Pettersson Ingrid; Knudsen Lotte Bjerre; Holst Jens J; Lau Jesper
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Bioorganic & medicinal chemistry letters 2007;17(19):5472-8.
2007: Hagemann Dirk; Holst Jens J; Gethmann Arnica; Banasch Matthias; Schmidt Wolfgang E; Meier Juris J
Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion.
Regulatory peptides 2007;143(1-3):64-8.
2007: Cani Patrice D; Holst Jens J; Drucker Daniel J; Delzenne Nathalie M; Thorens Bernard; Burcelin Rémy; Knauf Claude
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Molecular and cellular endocrinology 2007;276(1-2):18-23.
2007: Meier Juris J; Holst Jens J; Schmidt Wolfgang E; Nauck Michael A
Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E849-56.
2007: Pörksen Sven; Nielsen Lotte B; Kaas Anne; Kocova Mirjana; Chiarelli Francesco; Orskov Cathrine; Holst Jens J; Ploug Kenneth B; Hougaard Philip; Hansen Lars; Mortensen Henrik B;
Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(8):2910-6.
2007: Knop Filip K; Vilsbøll Tina; Højberg Patricia V; Larsen Steen; Madsbad Sten; Vølund Aage; Holst Jens J; Krarup Thure
Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Diabetes 2007;56(8):1951-9.
2007: Holst Jens J; Hartmann Bolette; Gottschalck Ida B; Jeppesen Palle B; Miholic Johannes; Henriksen Dennis Bang
Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate.
Scandinavian journal of gastroenterology 2007;42(7):814-20.
2007: Simonsen Lotte; Pilgaard Sofie; Orskov Cathrine; Rosenkilde Mette M; Hartmann Bolette; Holst Jens J; Deacon Carolyn F
Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G288-95.
2007: Sigalet David L; Wallace Laurie E; Holst Jens J; Martin Gary R; Kaji Tatsuru; Tanaka Hiroaki; Sharkey Keith A
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G211-21.
2007: Nielsen Lotte B; Ploug Kenneth B; Swift Peter; Ørskov Cathrine; Jansen-Olesen Inger; Chiarelli Francesco; Holst Jens J; Hougaard Philip; Pörksen Sven; Holl Reinhard; de Beaufort Carine; Gammeltoft Steen; Rorsman Patrik; Mortensen Henrik B; Hansen Lars;
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156(6):663-71.
2007: Staehr Peter; Hother-Nielsen Ole; Beck-Nielsen Henning; Roden Michael; Stingl Harald; Holst Jens J; Jones Paul K; Chandramouli Visvanathan; Landau Bernard R
Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis.
American journal of physiology. Endocrinology and metabolism 2007;292(5):E1265-9.
2007: Nilsson Mikael; Holst Jens J; Björck Inger Me
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks.
The American journal of clinical nutrition 2007;85(4):996-1004.
2007: Kien C Lawrence; Blauwiekel Ruth; Bunn Janice Y; Jetton Thomas L; Frankel Wendy L; Holst Jens J
Cecal infusion of butyrate increases intestinal cell proliferation in piglets.
The Journal of nutrition 2007;137(4):916-22.
2007: Balas Bogdan; Baig Muhammad R; Watson Catherine; Dunning Beth E; Ligueros-Saylan Monica; Wang Yibin; He Yan-Ling; Darland Celia; Holst Jens J; Deacon Carolyn F; Cusi Kenneth; Mari Andrea; Foley James E; DeFronzo Ralph A
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2007;92(4):1249-55.
2007: Henriksen Dennis B; Alexandersen Peter; Hartmann Bolette; Adrian Charlotte L; Byrjalsen Inger; Bone Henry G; Holst Jens J; Christiansen Claus
Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women.
Bone 2007;40(3):723-9.
2007: de Heer Jocelyn; Holst Jens J
Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1.
Diabetes 2007;56(2):438-43.
2007: Miholic J; Hoffmann M; Holst J J; Lenglinger J; Mittlböck M; Bergmann H; Stacher G
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication.
Surgical endoscopy 2007;21(2):309-14.
2007: Hansen Lene; Hare Kristine J; Hartmann Bolette; Deacon Carolyn F; Ugleholdt Randi K; Plamboeck Astrid; Holst Jens J
Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.
Regulatory peptides 2007;138(2-3):126-32.
2007: Knudsen Lotte Bjerre; Kiel Dan; Teng Min; Behrens Carsten; Bhumralkar Dilip; Kodra János T; Holst Jens J; Jeppesen Claus B; Johnson Michael D; de Jong Johannes Cornelis; Jorgensen Anker Steen; Kercher Tim; Kostrowicki Jarek; Madsen Peter; Olesen Preben H; Petersen Jacob S; Poulsen Fritz; Sidelmann Ulla G; Sturis Jeppe; Truesdale Larry; May John; Lau Jesper
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):937-42.
2007: Nagell Carl Frederic; Pedersen Jan F; Holst Jens J
The antagonistic metabolite of GLP-1, GLP-1 (9-36)amide, does not influence gastric emptying and hunger sensations in man.
Scandinavian journal of gastroenterology 2007;42(1):28-33.
2007: Knop Filip K; Vilsbøll Tina; Larsen Steen; Højberg Patricia V; Vølund Aage; Madsbad Sten; Holst Jens J; Krarup Thure
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E324-30.
2007: He Yan-Ling; Serra Denise; Wang Yibin; Campestrini Joelle; Riviere Gilles-Jacques; Deacon Carolyn F; Holst Jens J; Schwartz Sherwyn; Nielsen Jace C; Ligueros-Saylan Monica
Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.
Clinical pharmacokinetics 2007;46(7):577-88.
2007: Bodé Susan; Hartmann Bolette; Holst Jens J; Greisen Gorm
Glucagon-like peptide-2 in umbilical cord blood from mature infants.
Neonatology 2007;91(1):49-53.
2006: Flint Anne; Møller Bente K; Raben Anne; Sloth Birgitte; Pedersen Dorthe; Tetens Inge; Holst Jens J; Astrup Arne
Glycemic and insulinemic responses as determinants of appetite in humans.
The American journal of clinical nutrition 2006;84(6):1365-73.
2006: Banasch Matthias; Bulut Kerem; Hagemann Dirk; Schrader Henning; Holst Jens J; Schmidt Wolfgang E; Meier Juris J
Glucagon-like peptide 2 inhibits ghrelin secretion in humans.
Regulatory peptides 2006;137(3):173-8.
2006: Muscelli Elza; Mari Andrea; Natali Andrea; Astiarraga Brenno D; Camastra Stefania; Frascerra Silvia; Holst Jens J; Ferrannini Ele
Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1144-50.
2006: Liu Xiaowen; Nelson David W; Holst Jens J; Ney Denise M
Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome.
The American journal of clinical nutrition 2006;84(5):1142-50.
2006: Weickert Martin O; Spranger Joachim; Holst Jens J; Otto Bärbel; Koebnick Corinna; Möhlig Matthias; Pfeiffer Andreas F H
Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety.
The British journal of nutrition 2006;96(5):795-8.
2006: Nelson David W; Liu Xiaowen; Holst Jens J; Raybould Helen E; Ney Denise M
Vagal afferents are essential for maximal resection-induced intestinal adaptive growth in orally fed rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1256-64.
2006: Herman Gary A; Bergman Arthur; Stevens Catherine; Kotey Paul; Yi Bingming; Zhao Peng; Dietrich Bruno; Golor George; Schrodter Andreas; Keymeulen Bart; Lasseter Kenneth C; Kipnes Mark S; Snyder Karen; Hilliard Deborah; Tanen Michael; Cilissen Caroline; De Smet Marina; de Lepeleire Inge; Van Dyck Kristien; Wang Amy Q; Zeng Wei; Davies Michael J; Tanaka Wesley; Holst Jens J; Deacon Carolyn F; Gottesdiener Keith M; Wagner John A
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(11):4612-9.
2006: Deacon Carolyn F; Plamboeck Astrid; Rosenkilde Mette M; de Heer Jocelyn; Holst Jens J
GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E468-75.
2006: Pearson Ewan R; Flechtner Isabelle; Njølstad Pål R; Malecki Maciej T; Flanagan Sarah E; Larkin Brian; Ashcroft Frances M; Klimes Iwar; Codner Ethel; Iotova Violeta; Slingerland Annabelle S; Shield Julian; Robert Jean-Jacques; Holst Jens J; Clark Penny M; Ellard Sian; Søvik Oddmund; Polak Michel; Hattersley Andrew T;
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
The New England journal of medicine 2006;355(5):467-77.
2006: Wachters-Hagedoorn Renate E; Priebe Marion G; Heimweg Janneke A J; Heiner A Marius; Englyst Klaus N; Holst Jens J; Stellaard Frans; Vonk Roel J
The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men.
The Journal of nutrition 2006;136(6):1511-6.
2006: Meier Juris J; Gethmann Arnica; Nauck Michael A; Götze Oliver; Schmitz Frank; Deacon Carolyn F; Gallwitz Baptist; Schmidt Wolfgang E; Holst Jens J
The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1118-23.
2006: Sangild Per T; Siggers Richard H; Schmidt Mette; Elnif Jan; Bjornvad Charlotte R; Thymann Thomas; Grondahl Marie L; Hansen Axel K; Jensen Soeren K; Boye Mette; Moelbak Lars; Buddington Randal K; Weström Björn R; Holst Jens J; Burrin Douglas G
Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs.
Gastroenterology 2006;130(6):1776-92.
2006: Buemann B; Astrup A; Pedersen O; Black E; Holst C; Toubro S; Echwald S; Holst J J; Rasmussen C; Sørensen T I A
Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids.
The Journal of clinical endocrinology and metabolism 2006;91(5):1698-704.
2006: Ugleholdt Randi; Poulsen Marie-Louise H; Holst Peter J; Irminger Jean-Claude; Orskov Cathrine; Pedersen Jens; Rosenkilde Mette M; Zhu Xiaorong; Steiner Donald F; Holst Jens J
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
The Journal of biological chemistry 2006;281(16):11050-7.
2006: Meier Juris J; Nauck Michael A; Kask Bartholomaeus; Holst Jens J; Deacon Carolyn F; Schmidt Wolfgang E; Gallwitz Baptist
Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.
World journal of gastroenterology : WJG 2006;12(12):1874-80.
2006: Blom Wendy A M; Lluch Anne; Stafleu Annette; Vinoy Sophie; Holst Jens J; Schaafsma Gertjan; Hendriks Henk F J
Effect of a high-protein breakfast on the postprandial ghrelin response.
The American journal of clinical nutrition 2006;83(2):211-20.
2006: Blom Wendy A M; Lluch Anne; Vinoy Sophie; Stafleu Annette; van den Berg Robin; Holst Jens J; Kok Frans J; Hendriks Henk F J
Effects of gastric emptying on the postprandial ghrelin response.
American journal of physiology. Endocrinology and metabolism 2006;290(2):E389-95.
2006: Guan Xinfu; Karpen Heidi E; Stephens John; Bukowski John T; Niu Sanyong; Zhang Guangcheng; Stoll Barbara; Finegold Milton J; Holst Jens J; Hadsell Darryl; Nichols Buford L; Burrin Douglas G
GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.
Gastroenterology 2006;130(1):150-64.
2006: Meier Juris J; Nauck Michael A; Pott Andrea; Heinze Kai; Goetze Oliver; Bulut Kerem; Schmidt Wolfgang E; Gallwitz Baptist; Holst Jens J
Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans.
Gastroenterology 2006;130(1):44-54.
2006: Stoll Barbara; Price Pamela T; Reeds Peter J; Chang Xiaoyan; Henry Josef F; van Goudoever Johannes B; Holst Jens J; Burrin Douglas G
Feeding an elemental diet vs a milk-based formula does not decrease intestinal mucosal growth in infant pigs.
JPEN. Journal of parenteral and enteral nutrition 2006;30(1):32-9.
2006: Deacon Carolyn F; Holst Jens J
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.
The international journal of biochemistry & cell biology 2006;38(5-6):831-44.
2005: Fehse Frauke; Trautmann Michael; Holst Jens J; Halseth Amy E; Nanayakkara Nuwan; Nielsen Loretta L; Fineman Mark S; Kim Dennis D; Nauck Michael A
Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(11):5991-7.
2005: Flint Anne; Møller Bente K; Raben Anne; Tetens Inge; Holst Jens J; Astrup Arne
The use of glycaemic index tables to predict glycaemic index of breakfast meals.
The British journal of nutrition 2005;94(1):135-6.
2005: Torekov Signe S; Larsen Lesli H; Glümer Charlotte; Borch-Johnsen Knut; Jørgensen Torben; Holst Jens J; Madsen Ole D; Hansen Torben; Pedersen Oluf
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.
Diabetes 2005;54(7):2261-5.
2005: Meier Juris J; Kemmeries Guido; Holst Jens J; Nauck Michael A
Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects.
Diabetes 2005;54(7):2212-8.
2005: Buemann B; Sørensen T I A; Pedersen O; Black E; Holst C; Toubro S; Echwald S; Holst J J; Rasmussen C; Astrup A
Lower-body fat mass as an independent marker of insulin sensitivity--the role of adiponectin.
International journal of obesity (2005) 2005;29(6):624-31.
2005: Martin G R; Wallace L E; Hartmann B; Holst J J; Demchyshyn L; Toney K; Sigalet D L
Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(3):G431-8.
2005: Schmidt Peter T; Ljung Tryggve; Hartmann Bolette; Hare Kristine J; Holst Jens J; Hellström Per M
Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY.
European journal of gastroenterology & hepatology 2005;17(2):207-12.
2005: Burrin Douglas G; Stoll Barbara; Guan Xinfu; Cui Liwei; Chang Xiaoyan; Holst Jens J
Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets.
Endocrinology 2005;146(1):22-32.
2004: Meier Juris J; Gallwitz Baptist; Kask Bartholomaeus; Deacon Carolyn F; Holst Jens J; Schmidt Wolfgang E; Nauck Michael A
Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.
Diabetes 2004;53 Suppl 3():S220-4.
2004: Nilsson Mikael; Stenberg Marianne; Frid Anders H; Holst Jens J; Björck Inger M E
Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins.
The American journal of clinical nutrition 2004;80(5):1246-53.
2004: Nauck Michael A; El-Ouaghlidi Andrea; Gabrys Bartholomäus; Hücking Katrin; Holst Jens J; Deacon Carolyn F; Gallwitz Baptist; Schmidt Wolfgang E; Meier Juris J
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.
Regulatory peptides 2004;122(3):209-17.
2004: Hansen Lene; Lampert Sarah; Mineo Hitoshi; Holst Jens J
Neural regulation of glucagon-like peptide-1 secretion in pigs.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E939-47.
2004: Paris Monique C; Fuller Peter J; Carstensen Bendix; Nagy Eva; Taylor Russell G; Sourial Magdy; Holst Jens J; Hartmann Bolette; Binesm Julie E
Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens.
Digestive diseases and sciences 2004;49(10):1688-95.
2004: Degerman Eva; Manganiello Vincent; Holst Jens J; Ahrén Bo
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
European journal of pharmacology 2004;498(1-3):319-23.
2004: Deacon Carolyn F; Ahrén Bo; Holst Jens J
Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Expert opinion on investigational drugs 2004;13(9):1091-102.
2004: Sigalet David L; Martin Gary; Meddings Jon; Hartman Bolette; Holst Jens J
GLP-2 levels in infants with intestinal dysfunction.
Pediatric research 2004;56(3):371-6.
2004: Trebbien Ramona; Klarskov Letty; Olesen Mette; Holst Jens J; Carr Richard D; Deacon Carolyn F
Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.
American journal of physiology. Endocrinology and metabolism 2004;287(3):E431-8.
2004: Bartholome Anne L; Albin David M; Baker David H; Holst Jens J; Tappenden Kelly A
Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets.
JPEN. Journal of parenteral and enteral nutrition 2004;28(4):210-22; discussion 222-3.
2004: Flint Anne; Møller Bente K; Raben Anne; Pedersen Dorthe; Tetens Inge; Holst Jens J; Astrup Arne
The use of glycaemic index tables to predict glycaemic index of composite breakfast meals.
The British journal of nutrition 2004;91(6):979-89.
2004: Niinikoski Harri; Stoll Barbara; Guan Xinfu; Kansagra Ketan; Lambert Barry D; Stephens John; Hartmann Bolette; Holst Jens J; Burrin Douglas G
Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets.
The Journal of nutrition 2004;134(6):1467-74.
2004: Calbet Jose A L; Holst Jens J
Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans.
European journal of nutrition 2004;43(3):127-39.
2004: Hansotia Tanya; Baggio Laurie L; Delmeire Dominique; Hinke Simon A; Yamada Yuichiro; Tsukiyama Katsushi; Seino Yutaka; Holst Jens J; Schuit Frans; Drucker D J
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.
Diabetes 2004;53(5):1326-35.
2004: Nauck Michael A; Walberg Jörg; Vethacke Arndt; El-Ouaghlidi Andrea; Senkal Metin; Holst Jens J; Gallwitz Baptist; Schmidt Wolfgang E; Schmiegel W
Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like peptide 1.
Regulatory peptides 2004;118(1-2):89-97.
2004: Hansen Lene; Hartmann Bolette; Mineo Hitoshi; Holst Jens J
Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum.
Regulatory peptides 2004;118(1-2):11-8.
2004: Meier Juris J; Goetze Oliver; Anstipp Jens; Hagemann Dirk; Holst Jens J; Schmidt Wolfgang E; Gallwitz Baptist; Nauck Michael A
Gastric inhibitory polypeptide does not inhibit gastric emptying in humans.
American journal of physiology. Endocrinology and metabolism 2004;286(4):E621-5.
2004: Meier Juris J; Weyhe Dirk; Michaely Mark; Senkal Metin; Zumtobel Volker; Nauck Michael A; Holst Jens J; Schmidt Wolfgang E; Gallwitz Baptist
Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes.
Critical care medicine 2004;32(3):848-51.
2004: Meier Juris J; Nauck Michael A; Kranz Daniel; Holst Jens J; Deacon Carolyn F; Gaeckler Dirk; Schmidt Wolfgang E; Gallwitz Baptist
Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
Diabetes 2004;53(3):654-62.
2004: Ugleholdt Randi; Zhu Xiaorong; Deacon Carolyn F; Ørskov Cathrine; Steiner Donald F; Holst Jens J
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Endocrinology 2004;145(3):1349-55.
2004: Dalgaard Marian; Thomsen Claus; Rasmussen Birthe M; Holst Jens J; Hermansen Kjeld
Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients.
Metabolism: clinical and experimental 2004;53(1):77-83.
2004: Gregersen Søren; Jeppesen Per B; Holst Jens J; Hermansen Kjeld
Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Metabolism: clinical and experimental 2004;53(1):73-6.
2003: Henriksen Dennis B; Alexandersen Peter; Bjarnason Nina H; Vilsbøll Tina; Hartmann Bolette; Henriksen Eva E G; Byrjalsen Inger; Krarup Thure; Holst Jens J; Christiansen Claus
Role of gastrointestinal hormones in postprandial reduction of bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(12):2180-9.
2003: Meier Juris J; Nauck Michael A; Siepmann Nina; Greulich Michael; Holst Jens J; Deacon Carolyn F; Schmidt Wolfgang E; Gallwitz Baptist
Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.
Metabolism: clinical and experimental 2003;52(12):1579-85.
2003: Jackson Robert S; Creemers John W M; Farooqi I Sadaf; Raffin-Sanson Marie-Laure; Varro Andrea; Dockray Graham J; Holst Jens J; Brubaker Patricia L; Corvol Pierre; Polonsky Kenneth S; Ostrega Diane; Becker Kenneth L; Bertagna Xavier; Hutton John C; White Anne; Dattani Mehul T; Hussain Khalid; Middleton Stephen J; Nicole Thomasina M; Milla Peter J; Lindley Keith J; O'Rahilly Stephen
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
The Journal of clinical investigation 2003;112(10):1550-60.
2003: Juntunen Katri S; Laaksonen David E; Autio Karin; Niskanen Leo K; Holst Jens J; Savolainen Kari E; Liukkonen Kirsi-Helena; Poutanen Kaisa S; Mykkänen Hannu M
Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread.
The American journal of clinical nutrition 2003;78(5):957-64.
2003: Ahrén Bo; Holst Jens J; Mari Andrea
Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans.
Diabetes care 2003;26(10):2860-4.
2003: Knop Filip K; Vilsbøll Tina; Larsen Steen; Madsbad Sten; Holst Jens J; Krarup Thure
No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis.
Diabetes care 2003;26(9):2581-7.
2003: Deacon Carolyn F; Kelstrup Mette; Trebbien Ramona; Klarskov Letty; Olesen Mette; Holst Jens J
Differential regional metabolism of glucagon in anesthetized pigs.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E552-60.
2003: Guan Xinfu; Stoll Barbara; Lu Xiaofeng; Tappenden Kelly A; Holst Jens J; Hartmann Bolette; Burrin Douglas G
GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1.
Gastroenterology 2003;125(1):136-47.
2003: Vilsbøll Tina; Krarup Thure; Madsbad Sten; Holst Jens J
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects.
Regulatory peptides 2003;114(2-3):115-21.
2003: Jensen Christine B; Storgaard Heidi; Holst Jens J; Dela Flemming; Madsbad Sten; Vaag Allan A
Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men.
The Journal of clinical endocrinology and metabolism 2003;88(6):2775-83.
2003: Meier Juris J; Gallwitz Baptist; Salmen Stefan; Goetze Oliver; Holst Jens J; Schmidt Wolfgang E; Nauck Michael A
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(6):2719-25.
2003: Petersen Yvette M; Hartmann Bolette; Holst Jens J; Le Huerou-Luron Isabelle; Bjørnvad Charlotte R; Sangild Per T
Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development.
The Journal of nutrition 2003;133(6):1781-6.
2003: Meier Juris J; Gallwitz Baptist; Siepmann Nina; Holst Jens J; Deacon Carolyn F; Schmidt Wolfgang E; Nauck Michael A
The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).
Regulatory peptides 2003;113(1-3):95-100.
2003: Dahly Elizabeth M; Gillingham Melanie B; Guo Ziwen; Murali Sangita G; Nelson David W; Holst Jens J; Ney Denise M
Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G670-82.
2003: Thomsen Claus; Storm Hanne; Holst Jens J; Hermansen Kjeld
Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes.
The American journal of clinical nutrition 2003;77(3):605-11.
2003: Kjems Lise L; Holst Jens J; Vølund Aage; Madsbad Sten
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects.
Diabetes 2003;52(2):380-6.
2003: Raben Anne; Agerholm-Larsen Lisa; Flint Anne; Holst Jens J; Astrup Arne
Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake.
The American journal of clinical nutrition 2003;77(1):91-100.
2003: Plamboeck Astrid; Holst Jens J; Carr Richard D; Deacon Carolyn F
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.
Advances in experimental medicine and biology 2003;524():303-12.
2002: Hansen Lene; Holst Jens J
The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?
Regulatory peptides 2002;110(1):39-45.
2002: Zhu Xiaorong; Zhou An; Dey Arunangsu; Norrbom Christina; Carroll Raymond; Zhang Chunling; Laurent Virginie; Lindberg Iris; Ugleholdt Randi; Holst Jens J; Steiner Donald F
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10293-8.
2002: Deacon Carolyn F; Holst Jens J
Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Biochemical and biophysical research communications 2002;294(1):1-4.
2002: Deacon Carolyn F; Plamboeck Astrid; Møller Søren; Holst Jens J
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E873-9.
2002: Nauck Michael A; Heimesaat Markus M; Behle Kai; Holst Jens J; Nauck Markus S; Ritzel Robert; Hüfner Michael; Schmiegel Wolff H
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers.
The Journal of clinical endocrinology and metabolism 2002;87(3):1239-46.
2002: Johansson Asa; Olsson Tommy; Cederquist Kristina; Forsberg Hakan; Holst Jens J; Seckl Jonathan R; Ahren Bo
Abnormal release of incretins and cortisol after oral glucose in subjects with insulin-resistant myotonic dystrophy.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(3):397-405.
2002: Juntunen Katri S; Niskanen Leo K; Liukkonen Kirsi H; Poutanen Kaisa S; Holst Jens J; Mykkänen Hannu M
Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects.
The American journal of clinical nutrition 2002;75(2):254-62.
2002: Holst Jens J
Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2002;16(3):175-81.
2001: Rask E; Olsson T; Söderberg S; Johnson O; Seckl J; Holst J J; Ahrén B;
Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.
Diabetes care 2001;24(9):1640-5.
2001: Flint A; Raben A; Ersbøll A K; Holst J J; Astrup A
The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(6):781-92.
2001: van Goudoever J B; Stoll B; Hartmann B; Holst J J; Reeds P J; Burrin D G
Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets.
The Journal of nutrition 2001;131(3):729-32.
2001: Raben A; Holst J J; Madsen J; Astrup A
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women.
The American journal of clinical nutrition 2001;73(2):177-89.
2000: Burrin D G; Stoll B; Jiang R; Petersen Y; Elnif J; Buddington R K; Schmidt M; Holst J J; Hartmann B; Sangild P T
GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1249-56.
2000: Burrin D G; Stoll B; Jiang R; Chang X; Hartmann B; Holst J J; Greeley G H; Reeds P J
Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?
The American journal of clinical nutrition 2000;71(6):1603-10.
2000: Flint A; Raben A; Rehfeld J F; Holst J J; Astrup A
The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(3):288-98.
1999: Holst J J
Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1.
Expert opinion on investigational drugs 1999;8(9):1409-15.
1999: Plöckinger U; Holst J J; Messerschmidt D; Hopfenmüller W; Quabbe H J
Octreotide suppresses the incretin glucagon-like peptide (7-36) amide in patients with acromegaly or clinically nonfunctioning pituitary tumors and in healthy subjects.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):538-44.
1999: Thomsen C; Rasmussen O; Lousen T; Holst J J; Fenselau S; Schrezenmeir J; Hermansen K
Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects.
The American journal of clinical nutrition 1999;69(6):1135-43.
1998: Flint A; Raben A; Astrup A; Holst J J
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
The Journal of clinical investigation 1998;101(3):515-20.
1997: Furuta M; Yano H; Zhou A; Rouillé Y; Holst J J; Carroll R; Ravazzola M; Orci L; Furuta H; Steiner D F
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6646-51.

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