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Jens Holst

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Anita Belza; Jens J Holst; Jens F Rehfeld; Christian Ritz; Mejse Q Sørensen; Arne Astrup
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety.
S Calanna; M Christensen; L L Gluud; Jens J Holst; B Laferrère; T Vilsbøll; F K Knop
Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies.
Thomas Idorn; Morten Jørgensen; Filip K Knop; Jens J Holst; Mads Hornum; Bo Feldt-Rasmussen
Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease.

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2013: Anita Belza; Jens J Holst; Jens F Rehfeld; Christian Ritz; Mejse Q Sørensen; Arne Astrup
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety.
The American journal of clinical nutrition 2013;97(5):980-9.
2013: S Calanna; M Christensen; L L Gluud; Jens J Holst; B Laferrère; T Vilsbøll; F K Knop
Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies.
Diabetologia 2013;56(5):965-72.
2013: Thomas Idorn; Morten Jørgensen; Filip K Knop; Jens J Holst; Mads Hornum; Bo Feldt-Rasmussen
Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease.
Kidney international 2013;83(5):915-23.
2013: Daniël H van Raalte; Carolyn F Deacon; Robert J Heine; Jens J Holst; John M Karemaker; Kelly A A Kwa; Andrea Mari; Maarten E Tushuizen; Renate E van Genugten; Michaela Diamant
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
Metabolism: clinical and experimental 2013;62(4):568-77.
2013: Camilla Kappe; Cesare Patrone; Jens J Holst; Qimin Zhang; Ake Sjöholm
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells.
Journal of gastroenterology 2013;48(3):322-32.
2013: David P Sonne; Tina Vilsbøll; Kristine J Hare; Jens J Holst; Pernille Martens; Jens F Rehfeld; Filip K Knop
Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients.
American journal of physiology. Gastrointestinal and liver physiology 2013;304(4):G413-9.
2013: Carsten Askov-Hansen; Bolette Hartmann; Jens J Holst; Palle B Jeppesen; Pernille Lund; Dennis B Henriksen
Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure.
Regulatory peptides 2013;181():4-8.
2013: Annesofie Faurschou; Mette Gyldenløve; Jens J Holst; Jens Pedersen; Steen S Poulsen; Lone Skov; Jacob P Thyssen; Tina Vilsbøll; Claus Zachariae; Filip K Knop
Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques.
Experimental dermatology 2013;22(2):150-2.
2013: Thomas Idorn; Tonny Jensen; Morten Jørgensen; Filip K Knop; Marsela Resuli; Karl Bang Christensen; Pernille M Hansen; Jens J Holst; Mads Hornum; Bo Feldt-Rasmussen
Safety and efficacy of liraglutide in patients with type 2 diabetes and end-stage renal disease: protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded, parallel intervention study.
BMJ open 2013;3(4):.
2013: Michael Gejl; Bo M Bibby; Birgitte Brock; Lærke Egefjord; Jens J Holst; Susanne Lerche; Niels Møller; Anders Rodell; Jørgen Rungby; Kim Vang; Albert Gjedde
Glucagon-like peptide-1 (GLP-1) raises blood-brain glucose transfer capacity and hexokinase activity in human brain.
Frontiers in neuroenergetics 2013;5():2.
2013: Jens Holmer-Jensen; Jens J Holst; Lene S Mortensen; Claus Thomsen; Arne Astrup; Michael de Vrese; Kjeld Hermansen
Acute differential effects of dietary protein quality on postprandial lipemia in obese non-diabetic subjects.
Nutrition research (New York, N.Y.) 2013;33(1):34-40.
2012: Kristoffer Lihme Egerod; Maja S Engelstoft; Ernst-Martin Füchtbauer; Kaare V Grunddal; Jens J Holst; Mark K Nøhr; Jørgen Olsen; Jesper V Olsen; Jens Pedersen; Steen S Poulsen; Ichiro Sakata; Anna Secher; Frank Sundler; Nils Wierup; Johanne A Windeløv; Jeffrey M Zigman; Jan P Christensen; Thue W Schwartz
A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin.
Endocrinology 2012;153(12):5782-95.
2012: Thomas P J Solomon; Kamilla Winding; Jens J Holst; Kristian Karstoft; Sine H Knudsen; Bente K Pedersen
Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity.
The Journal of clinical endocrinology and metabolism 2012;97(12):4682-91.
2012: Thomas Rauch; Arne Ring; Hans-Juergen Woerle; Jens J Holst; Carolyn F Deacon; Klaus A Dugi; Ulrike Graefe-Mody; Tim Heise
Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus.
Diabetes therapy : research, treatment and education of diabetes and related disorders 2012;3(1):10.
2012: Camilla Kappe; Jens J Holst; Qimin Zhang; Ake Sjöholm
Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells.
Biochemical and biophysical research communications 2012;427(1):91-5.
2012: Adam S Brinkman; Stacy Hitt; Jens J Holst; Sangita G Murali; Patrick M Solverson; Denise M Ney
Enteral nutrients potentiate glucagon-like peptide-2 action and reduce dependence on parenteral nutrition in a rat model of human intestinal failure.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(5):G610-22.
2012: Pernille F Svendsen; Lisbeth Nilas; Steen B Haugaard; Jens J Holst; Frank K Jensen; Sten Madsbad
The effect of a very low calorie diet on insulin sensitivity, beta cell function, insulin clearance, incretin hormone secretion, androgen levels and body composition in obese young women.
Scandinavian journal of clinical and laboratory investigation 2012;72(5):410-9.
2012: Jennifer L Barnes; Bolette Hartmann; Jens J Holst; Kelly Tappenden
Intestinal adaptation is stimulated by partial enteral nutrition supplemented with the prebiotic short-chain fructooligosaccharide in a neonatal intestinal failure piglet model.
JPEN. Journal of parenteral and enteral nutrition 2012;36(5):524-37.
2012: Harald S Hansen; Jens J Holst; Mette M Rosenkilde; Thue W Schwartz
GPR119 as a fat sensor.
Trends in pharmacological sciences 2012;33(7):374-81.
2012: K S Myint; I S Farooqi; J R Greenfield; E Henning; Jens J Holst; Nick Finer
Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue.
European journal of endocrinology / European Federation of Endocrine Societies 2012;166(5):951-5.
2012: Stefan Rohrer; Wolfgang E Schmidt; Johannes D Veldhuis; Björn A Menge; Carolyn F Deacon; Lena Grüber; Jens J Holst; Juris J Meier
Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals.
The Journal of clinical endocrinology and metabolism 2012;97(5):E791-5.
2012: Katrine B Hansen; Jens J Holst; Jonatan I Bagger; Tina Vilsbøll; Filip K Knop
Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects.
The Journal of clinical endocrinology and metabolism 2012;97(4):1363-70.
2012: Jacob Sivertsen; Jens J Holst; Jaya Rosenmeier; Tina Vilsbøll
The effect of glucagon-like peptide 1 on cardiovascular risk.
Nature reviews. Cardiology 2012;9(4):209-22.
2012: Ulrika Gunnerud; Jens J Holst; Elin M Ostman; Inger M E Björck
The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human milk.
Nutrition journal 2012;11():83.
2012: Ulrika J Gunnerud; Cornelia Heinzle; Jens J Holst; Elin M Ostman; Inger M E Björck
Effects of pre-meal drinks with protein and amino acids on glycemic and metabolic responses at a subsequent composite meal.
PloS one 2012;7(9):e44731.
2012: Albert Salehi; Inger M E Björck; Ulrika Gunnerud; Jens J Holst; Sarheed J Muhammed; Elin M Ostman; Patrik Rorsman
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells.
Nutrition & metabolism 2012;9(1):48.
2011: Mikkel Christensen; Jens J Holst; Louise Vedtofte; Tina Vilsbøll; Filip K Knop
Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans.
Diabetes 2011;60(12):3103-9.
2011: Jonas B Møller; Rune V Overgaard; Oluf Pedersen; William J Jusko; Henrik Madsen; Wei Gao; Torben Hansen; Jens J Holst; Steen H Ingwersen
Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test.
Journal of pharmacokinetics and pharmacodynamics 2011;38(6):713-25.
2011: Sabine Naessén; Jens J Holst; Kjell Carlström; Per M Hellström; Angelica Lindén Hirschberg
Women with bulimia nervosa exhibit attenuated secretion of glucagon-like peptide 1, pancreatic polypeptide, and insulin in response to a meal.
The American journal of clinical nutrition 2011;94(4):967-72.
2011: Katrine B Hansen; Jens J Holst; Filip K Knop; Jens F Rehfeld; Mette M Rosenkilde; Niels Wellner; Ulrik B Andersen; Thi A Diep; Harald S Hansen
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.
The Journal of clinical endocrinology and metabolism 2011;96(9):E1409-17.
2011: Inger Krog-Mikkelsen; Birgitte Sloth; Inge Tetens; Arne Astrup; Inger M E Björck; Dimiter Dimitrov; Helena Liljeberg Elmståhl; Anne Flint; Jens J Holst; Anne Raben
A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women.
The Journal of nutrition 2011;141(9):1679-84.
2011: Caroline Ketterer; Fausto Machicao; Karsten Müssig; Elko Randrianarisoa; Katarzyna Dudziak; Andreas Fritsche; Hans-Ulrich Häring; Martin Heni; Jens J Holst; Norbert Stefan; Robert Wagner; Harald Staiger
Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.
Metabolism: clinical and experimental 2011;60(9):1325-33.
2011: Mechteld A R Vermeulen; Michaela Diamant; E Marelise W Eekhoff; Martijn K Garretsen; Mohammed A Ghatei; Annemieke C Heijboer; Jens J Holst; Milan C Richir; Bernard M J Uitdehaag; Paul A M van Leeuwen; Annelies van Schie; Gerdien C Ligthart-Melis
Gastric emptying, glucose metabolism and gut hormones: evaluation of a common preoperative carbohydrate beverage.
Nutrition (Burbank, Los Angeles County, Calif.) 2011;27(9):897-903.
2011: Björn A Menge; Wolfgang E Schmidt; Johannes D Veldhuis; Carolyn F Deacon; Lena Grüber; Jens J Holst; Signe M Jørgensen; Juris J Meier
Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes.
Diabetes 2011;60(8):2160-8.
2011: Aurélie Waget; Mattieu Armanet; Cendrine Cabou; Julien Castel; Pierre Cattan; Daniel J Drucker; Celine Garret; Jens J Holst; Mélis Karaca; Christophe Magnan; Adriano Maida; Myriam Masseboeuf; Gaëlle Payros; Thierry Sulpice; Rémy Burcelin
Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice.
Endocrinology 2011;152(8):3018-29.
2011: Ola Lindgren; Andrea Mari; Giovanni Pacini; Richard D Carr; Carolyn F Deacon; Jens J Holst; Bo Ahrén
Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans.
The Journal of clinical endocrinology and metabolism 2011;96(8):2519-24.
2011: Dorit Samocha-Bonet; Emma-Leigh Synnott; Olivia Wong; Donald J Chisholm; Ashley Douglas; Fiona M Gribble; Jens J Holst; Naomi Piyaratna; Jerry R Greenfield
Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients.
The Journal of nutrition 2011;141(7):1233-8.
2011: Asger Lund; Tina Vilsbøll; Jonatan I Bagger; Jens J Holst; Filip K Knop
The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2011;300(6):E1038-46.
2011: Jens J Holst; Filip K Knop; Tina Vilsbøll; Thure Krarup; Sten Madsbad
Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes.
Diabetes care 2011;34 Suppl 2():S251-7.
2011: Urd Kielgast; Jens J Holst; Sten Madsbad
Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function.
Diabetes 2011;60(5):1599-607.
2011: Michael A Nauck; Guido Kemmeries; Jens J Holst; Juris J Meier
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans.
Diabetes 2011;60(5):1561-5.
2011: Lotte Usinger; Katrine B Hansen; Viggo B Kristiansen; Steen Larsen; Jens J Holst; Filip K Knop
Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding.
Obesity surgery 2011;21(5):625-32.
2011: Mikkel Christensen; Filip K Knop; Tina Vilsbøll; Jens J Holst
Lixisenatide for type 2 diabetes mellitus.
Expert opinion on investigational drugs 2011;20(4):549-57.
2011: Nikolaos Mentis; Irfan Vardarli; Lars D Köthe; Jens J Holst; Carolyn F Deacon; Michael Theodorakis; Juris J Meier; Michael A Nauck
GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes.
Diabetes 2011;60(4):1270-6.
2011: Irfan Vardarli; Michael A Nauck; Lars D Köthe; Carolyn F Deacon; Jens J Holst; Anja Schweizer; James E Foley
Inhibition of DPP-4 with vildagliptin improved insulin secretion in response to oral as well as "isoglycemic" intravenous glucose without numerically changing the incretin effect in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2011;96(4):945-54.
2011: Karen L Thomsen; Niels Kristian Aagaard; Henning Grønbaek; Jens J Holst; Niels Jessen; Jan Frystyk; Hendrik Vilstrup
IL-6 has no acute effect on the regulation of urea synthesis in vivo in rats.
Scandinavian journal of clinical and laboratory investigation 2011;71(2):150-6.
2011: Jonatan I Bagger; Filip K Knop; Asger Lund; Henrik Vestergaard; Jens J Holst; Tina Vilsbøll
Impaired regulation of the incretin effect in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2011;96(3):737-45.
2011: Katrine B Hansen; Tina Vilsbøll; Jonatan I Bagger; Jens J Holst; Filip K Knop
Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects.
The Journal of clinical endocrinology and metabolism 2011;96(2):447-53.
2011: Anette P Gjesing; Torben Hansen; Martin Heni; Jens J Holst; Torben Jørgensen; Marie A Vestmar; Daniel R Witte; Oluf Pedersen
The effect of PCSK1 variants on waist, waist-hip ratio and glucose metabolism is modified by sex and glucose tolerance status.
PloS one 2011;6(9):e23907.
2011: Britta E Hjerrild; Jens J Holst; Claus Juhl; Jens S Christiansen; Ole Schmitz; Claus Gravholt
Delayed β-cell response and glucose intolerance in young women with Turner syndrome.
BMC endocrine disorders 2011;11():6.
2011: Michael A Nauck; I Vardarli; C F Deacon; Jens J Holst; J J Meier
Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
Diabetologia 2011;54(1):10-8.
2010: Elizabeth Migoya; R Bergeron; J L Miller; R N K Snyder; Michael Tanen; Deborah Hilliard; B Weiss; P Larson; M Gutierrez; Guoqiang Jiang; Franklin Liu; K A Pryor; J Yao; Lan Zhu; Jens J Holst; C Deacon; Gary A Herman; Nancy A Thornberry; John M Amatruda; D Williams-Herman; John A Wagner; R SinhaRoy
Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1.
Clinical pharmacology and therapeutics 2010;88(6):801-8.
2010: Matthew C Koopmann; Xueyan Chen; Jens J Holst; Denise M Ney
Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure.
American journal of physiology. Gastrointestinal and liver physiology 2010;299(6):G1222-30.
2010: Anne C Nilsson; Elin M Östman; Knud Erik Bach Knudsen; Jens J Holst; Inger M E Björck
A cereal-based evening meal rich in indigestible carbohydrates increases plasma butyrate the next morning.
The Journal of nutrition 2010;140(11):1932-6.
2010: Mikkel Christensen; Filip K Knop; Tina Vilsbøll; Kasper Aaboe; Jens J Holst; Sten Madsbad; Thure Krarup
Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes.
Regulatory peptides 2010;163(1-3):96-101.
2010: Juris J Meier; Peter R Ritter; Alexandra Jacob; Bjoern A Menge; Carolyn F Deacon; Wolfgang E Schmidt; Michael A Nauck; Jens J Holst
Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans.
The Journal of clinical endocrinology and metabolism 2010;95(8):4061-5.
2010: Bruno Lapauw; Margriet Ouwens; Leen M 't Hart; Birgitte Wuyts; Jens J Holst; Guy T'Sjoen; Jean-Marc Kaufman; Johannes B Ruige
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
Diabetes care 2010;33(8):1831-3.
2010: Gerlies Bock; Chiara Dalla Man; Francesco Micheletto; Rita Basu; Paula D Giesler; Jeanette Laugen; Carolyn F Deacon; Jens J Holst; Gianna Toffolo; Claudio Cobelli; Robert A Rizza; Adrian Vella
The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose.
Clinical endocrinology 2010;73(2):189-96.
2010: Kristine J Hare; Tina Vilsbøll; Meena Asmar; Carolyn F Deacon; Filip K Knop; Jens J Holst
The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action.
Diabetes 2010;59(7):1765-70.
2010: Anni Larnkjaer; Lene Schack-Nielsen; Christian Mølgaard; Helga K Ingstrup; Jens J Holst; Kim Fleischer Michaelsen
Effect of growth in infancy on body composition, insulin resistance, and concentration of appetite hormones in adolescence.
The American journal of clinical nutrition 2010;91(6):1675-83.
2010: Esmaeel Taqi; Laurie E Wallace; Elaine de Heuvel; Prasanth K Chelikani; Huiyuan Zheng; Hans-Rudolph Berthoud; Jens J Holst; David L Sigalet
The influence of nutrients, biliary-pancreatic secretions, and systemic trophic hormones on intestinal adaptation in a Roux-en-Y bypass model.
Journal of pediatric surgery 2010;45(5):987-95.
2010: Urd Kielgast; Meena Asmar; Sten Madsbad; Jens J Holst
Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients.
The Journal of clinical endocrinology and metabolism 2010;95(5):2492-6.
2010: Meena Asmar; Michael Bache; Filip Knop; Sten Madsbad; Jens J Holst
Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
The Journal of clinical endocrinology and metabolism 2010;95(5):2367-75.
2010: Amra C Alibegovic; Mette P Sonne; Lise Højbjerre; Torben Hansen; Oluf Pedersen; Gerrit van Hall; Jens J Holst; Bente Stallknecht; Flemming Dela; Allan Vaag
The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.
Diabetes 2010;59(4):836-43.
2010: Kristine J Hare; Tina Vilsbøll; Jens J Holst; Filip K Knop
Inappropriate glucagon response after oral compared with isoglycemic intravenous glucose administration in patients with type 1 diabetes.
American journal of physiology. Endocrinology and metabolism 2010;298(4):E832-7.
2010: Josina M Rijkelijkhuizen; Kelly McQuarrie; Cynthia J Girman; Peter P Stein; Andrea Mari; Jens J Holst; Giel Nijpels; Jacqueline M Dekker
Effects of meal size and composition on incretin, alpha-cell, and beta-cell responses.
Metabolism: clinical and experimental 2010;59(4):502-11.
2010: Junji Kozawa; Kohei Okita; Akihisa Imagawa; Hiromi Iwahashi; Jens J Holst; Kazuya Yamagata; Iichiro Shimomura
Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes.
Biochemical and biophysical research communications 2010;393(3):410-3.
2010: Meena Asmar; Patricia V Højberg; Carolyn F Deacon; Kristine Hare; Jens J Holst; Sten Madsbad
Pancreatic beta-cell responses to GLP-1 after near-normalization of blood glucose in patients with type 2 diabetes.
Regulatory peptides 2010;160(1-3):175-80.
2010: Richard D Carr; Marianne O Larsen; Katarina Jelic; Ola Lindgren; Jenny Vikman; Jens J Holst; Carolyn F Deacon; Bo Ahrén
Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.
The Journal of clinical endocrinology and metabolism 2010;95(2):872-8.
2010: Carsten Dirksen; Dorte L Hansen; Sten Madsbad; Lisbeth E Hvolris; Lars S Naver; Jens J Holst; Dorte Worm
Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report.
Diabetes care 2010;33(2):375-7.
2010: Meena Asmar; Jens J Holst
Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances.
Current opinion in endocrinology, diabetes, and obesity 2010;17(1):57-62.
2010: Filip K Knop; Tina Vilsbøll; Asger Lund; Thure Krarup; Jens J Holst; Mads Hornum
The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency.
JOP : Journal of the pancreas 2010;11(5):489-91.
2010: Mads Hornum; JF Pedersen; S Larsen; O Olsen; Jens J Holst; Filip K Knop
Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2010;10(2-3):201-7.
2010: Carolyn F Deacon; Jens J Holst
Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes.
Expert opinion on investigational drugs 2010;19(1):133-40.
2010: Solrun Vidarsdottir; Ferdinand Roelfsema; Trea Streefland; Jens J Holst; Jens F Rehfeld; Hanno Pijl
Short-term treatment with olanzapine does not modulate gut hormone secretion: olanzapine disintegrating versus standard tablets.
European journal of endocrinology / European Federation of Endocrine Societies 2010;162(1):75-83.
2009: Kristine J Hare; Filip K Knop; Meena Asmar; Sten Madsbad; Carolyn F Deacon; Jens J Holst; Tina Vilsbøll
Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2009;94(12):4679-87.
2009: Karsten Müssig; Harald Staiger; Fausto Machicao; Jürgen Machann; Fritz Schick; Silke A Schäfer; Claus D Claussen; Jens J Holst; Baptist Gallwitz; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring
Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus.
Metabolism: clinical and experimental 2009;58(12):1809-11.
2009: Urd Kielgast; Jens J Holst; Sten Madsbad
Treatment of type 1 diabetic patients with glucagon-like peptide-1 (GLP-1) and GLP-1R agonists.
Current diabetes reviews 2009;5(4):266-75.
2009: Xiaowen Liu; Sangita G Murali; Jens J Holst; Denise M Ney
Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(5):R1554-62.
2009: Matthew C Koopmann; Xiaowen Liu; Christopher J Boehler; Sangita G Murali; Jens J Holst; Denise M Ney
Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome.
JPEN. Journal of parenteral and enteral nutrition 2009;33(6):629-38; discussion 638-9.
2009: Dennis B Henriksen; Peter Alexandersen; Bolette Hartmann; Charlotte L Adrian; Inger Byrjalsen; Henry G Bone; Jens J Holst; Claus Christiansen
Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD.
Bone 2009;45(5):833-42.
2009: Maud Le Gall; Mélanie Gallois; Bernard Sève; Isabelle Louveau; Jens J Holst; Isabelle P Oswald; Jean-Paul Lallès; Paul Guilloteau
Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets.
The British journal of nutrition 2009;102(9):1285-96.
2009: Richard W Gelling; Patricia Vuguin; Xiu Quan Du; Lingguang Cui; John Rømer; Raymond A Pederson; Margarita Leiser; Heidi Sørensen; Jens J Holst; Christian Fledelius; Peter Bygballe Johansen; Norman Fleischer; Christopher H S McIntosh; Erica Nishimura; Maureen J Charron
Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass.
American journal of physiology. Endocrinology and metabolism 2009;297(3):E695-707.
2009: Mary-Elizabeth Patti; Sander M Houten; Antonio Bianco; Raquel Bernier; P Reed Larsen; Jens J Holst; Michael K Badman; Eleftheria Maratos-Flier; Edward C Mun; Jussi Pihlajamaki; Johan Auwerx; Allison B Goldfine
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Obesity (Silver Spring, Md.) 2009;17(9):1671-7.
2009: Tina Vilsbøll; Jens J Holst; Filip K Knop
The spectrum of antidiabetic actions of GLP-1 in patients with diabetes.
Best practice & research. Clinical endocrinology & metabolism 2009;23(4):453-62.
2009: Carolyn F Deacon; Jens J Holst
Immunoassays for the incretin hormones GIP and GLP-1.
Best practice & research. Clinical endocrinology & metabolism 2009;23(4):425-32.
2009: Mikkel Christensen; Filip K Knop; Jens J Holst; Tina Vilsboll
Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus.
IDrugs : the investigational drugs journal 2009;12(8):503-13.
2009: Sandra Bonuccelli; Elza Muscelli; Amalia Gastaldelli; Elisabetta Barsotti; Brenno Astiarraga; Jens J Holst; Andrea Mari; Ele Ferrannini
Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms.
American journal of physiology. Endocrinology and metabolism 2009;297(2):E532-7.
2009: Henning Schrader; Bjoern A Menge; Thomas G K Breuer; Peter R Ritter; Waldemar Uhl; Wolfgang E Schmidt; Jens J Holst; Juris J Meier
Impaired glucose-induced glucagon suppression after partial pancreatectomy.
The Journal of clinical endocrinology and metabolism 2009;94(8):2857-63.
2009: Lene S Mortensen; Merete L Hartvigsen; Lea J Brader; Arne Astrup; Jürgen Schrezenmeir; Jens J Holst; Claus Thomsen; Kjeld Hermansen
Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein.
The American journal of clinical nutrition 2009;90(1):41-8.
2009: Karsten Müssig; Harald Staiger; Fausto Machicao; Kerstin Kirchhoff; Martina Guthoff; Silke A Schäfer; Konstantinos Kantartzis; Günther Silbernagel; Norbert Stefan; Jens J Holst; Baptist Gallwitz; Hans-Ulrich Häring; Andreas Fritsche
Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion.
Diabetes 2009;58(7):1715-20.
2009: Guido Bosch; Adronie Verbrugghe; Myriam Hesta; Jens J Holst; Antonius F B van der Poel; Geert P J Janssens; Wouter H Hendriks
The effects of dietary fibre type on satiety-related hormones and voluntary food intake in dogs.
The British journal of nutrition 2009;102(2):318-25.
2009: Birgitte Holst; Kristoffer Lihme Egerod; Chunyu Jin; Pia Steen Petersen; Mette Viberg Østergaard; Jacob Hald; A M Ejernaes Sprinkel; Joachim Størling; Thomas Mandrup-Poulsen; Jens J Holst; Peter Thams; Cathrine Orskov; Nils Wierup; Frank Sundler; Ole D Madsen; Thue W Schwartz
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.
Endocrinology 2009;150(6):2577-85.
2009: Birgitte Sloth; Anette Due; Thomas M Larsen; Jens J Holst; Anders Heding; Arne Astrup
The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period.
The British journal of nutrition 2009;101(12):1846-58.
2009: Carolyn F Deacon; Jens J Holst
Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.
Advances in therapy 2009;26(5):488-99.
2009: Kirsten Vollmer; Husai Gardiwal; Bjoern A Menge; Oliver Goetze; Carolyn F Deacon; Wolfgang E Schmidt; Jens J Holst; Juris J Meier
Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans.
The Journal of clinical endocrinology and metabolism 2009;94(4):1379-85.
2009: Tatsuru Kaji; Hiroaki Tanaka; Heather Redstone; Laurie E Wallace; Jens J Holst; David L Sigalet
Temporal changes in the intestinal growth promoting effects of glucagon-like peptide 2 following intestinal resection.
The Journal of surgical research 2009;152(2):271-80.
2009: Joanna Hlebowicz; Anna Hlebowicz; Sandra Lindstedt; Ola Björgell; Peter Höglund; Jens J Holst; Gassan Darwiche; Lars-Olof Almér
Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects.
The American journal of clinical nutrition 2009;89(3):815-21.
2009: Feruze Yilmaz Enç; Tunç Ones; H Levent Akin; Fuat Dede; H Turgut Turoğlu; Gözde Ulfer; Nural Bekiroğlu; Goncagül Haklar; Jens F Rehfeld; Jens J Holst; Nefise B Ulusoy; Nese Imeryüz
Orlistat accelerates gastric emptying and attenuates GIP release in healthy subjects.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G482-9.
2009: Kristine Faerch; Allan Vaag; Jens J Holst; Torben Hansen; Torben Jørgensen; Knut Borch-Johnsen
Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study.
Diabetes care 2009;32(3):439-44.
2009: Stine Chabert Olesen; Dorte Lindqvist Hansen; Thomas Almdal; Flemming Bendtsen; Inge Nordgaard; Lisbeth Edvardsen Hvolris; Jens J Holst; Lars Naver; Sten Madsbad
[Surgical treatment of diabetes mellitus type 2].
Ugeskrift for laeger 2009;171(8):615-7.
2009: Filip K Knop; Tina Vilsbøll; Jens J Holst
Incretin-based therapy of type 2 diabetes mellitus.
Current protein & peptide science 2009;10(1):46-55.
2009: Jerry R Greenfield; I Sadaf Farooqi; Julia M Keogh; Elana Henning; Abdella M Habib; Anthea Blackwood; Frank Reimann; Jens J Holst; Fiona M Gribble
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.
The American journal of clinical nutrition 2009;89(1):106-13.
2008: Xiaowen Liu; Sangita G Murali; Jens J Holst; Denise M Ney
Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(6):R1794-802.
2008: Tatsuru Kaji; Hiroaki Tanaka; Jens J Holst; Heather Redstone; Laurie Wallace; Elaine de Heuval; David L Sigalet
The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat.
European journal of pharmacology 2008;596(1-3):138-45.
2008: Mark Ellrichmann; Mario Kapelle; Peter R Ritter; Jens J Holst; Karl-Heinz Herzig; Wolfgang E Schmidt; Frank Schmitz; Juris J Meier
Orlistat inhibition of intestinal lipase acutely increases appetite and attenuates postprandial glucagon-like peptide-1-(7-36)-amide-1, cholecystokinin, and peptide YY concentrations.
The Journal of clinical endocrinology and metabolism 2008;93(10):3995-8.
2008: Filip K Knop; Jens J Holst; Tina Vilsbøll
Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility.
IDrugs : the investigational drugs journal 2008;11(7):497-501.
2008: Sten Madsbad; Thure Krarup; Carolyn F Deacon; Jens J Holst
Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials.
Current opinion in clinical nutrition and metabolic care 2008;11(4):491-9.
2008: Marli A Robertson; David L Sigalet; Jens J Holst; Jonathan B Meddings; Julie Wood; Keith Sharkey
Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study.
Journal of autism and developmental disorders 2008;38(6):1066-71.
2008: Lone B Sørensen; Heidi T Cueto; Maja T Andersen; Christian Bitz; Jens J Holst; Jens F Rehfeld; Arne Astrup
The effect of salatrim, a low-calorie modified triacylglycerol, on appetite and energy intake.
The American journal of clinical nutrition 2008;87(5):1163-9.
2008: Matthew C Koopmann; David W Nelson; Sangita G Murali; Xiaowen Liu; Mark S Brownfield; Jens J Holst; Denise M Ney
Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats.
JPEN. Journal of parenteral and enteral nutrition 2008;32(3):254-65.
2008: Elza Muscelli; Andrea Mari; Arturo Casolaro; Stefania Camastra; Giuseppe Seghieri; Amalia Gastaldelli; Jens J Holst; Ele Ferrannini
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients.
Diabetes 2008;57(5):1340-8.
2008: Anette Due; Thomas M Larsen; Kjeld Hermansen; Steen Stender; Jens J Holst; Søren Toubro; Torben Martinussen; Arne Astrup
Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets.
The American journal of clinical nutrition 2008;87(4):855-62.
2008: Anne C Nilsson; Elin M Ostman; Jens J Holst; Inger M E Björck
Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.
The Journal of nutrition 2008;138(4):732-9.
2008: Jens J Holst; Carolyn F Deacon; Tina Vilsbøll; Thure Krarup; Sten Madsbad
Glucagon-like peptide-1, glucose homeostasis and diabetes.
Trends in molecular medicine 2008;14(4):161-8.
2008: David W Nelson; Sangita G Murali; Xiaowen Liu; Matthew C Koopmann; Jens J Holst; Denise M Ney
Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(4):R1175-84.
2008: Ulrik Pedersen-Bjergaard; Carsten E Thomsen; Hans Høgenhaven; Annelise Smed; Troels W Kjaer; Jens J Holst; Flemming Dela; Linda Hilsted; Erik Frandsen; Stig Pramming; Birger Thorsteinsson
Angiotensin-converting enzyme activity and cognitive impairment during hypoglycaemia in healthy humans.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2008;9(1):37-48.
2008: Markku Laakso; J Zilinskaite; T Hansen; T Welløv Boesgaard; Markku Vänttinen; A Stancáková; Per-Anders Jansson; F Pellmé; Jens J Holst; Tiina Kuulasmaa; M L Hribal; Giorgio Sesti; Norbert Stefan; A Fritsche; H Häring; Oluf Pedersen; Ulf Smith
Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
Diabetologia 2008;51(3):502-11.
2008: Kirsten Vollmer; Jens J Holst; Birgit Baller; Mark Ellrichmann; Michael A Nauck; Wolfgang E Schmidt; Juris J Meier
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance.
Diabetes 2008;57(3):678-87.
2008: Nis B Pedersen; Karina R Hjollund; Anders H Johnsen; Cathrine Orskov; Mette M Rosenkilde; Bolette Hartmann; Jens J Holst
Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects.
Regulatory peptides 2008;146(1-3):310-20.
2008: Koichiro Azuma; Zofia Rádiková; Juliet Mancino; Frederico G S Toledo; Ernestine Thomas; Cyrous Kangani; Chiara Dalla Man; Claudio Cobelli; Jens J Holst; Carolyn F Deacon; Yanling He; Monica Ligueros-Saylan; Denise Serra; James Foley; David E Kelley
Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2008;93(2):459-64.
2008: Susanne Lerche; Birgitte Brock; Jørgen Rungby; Hans Erik Bøtker; Niels Møller; Anders Rodell; Bo Martin Bibby; Jens J Holst; Ole Schmitz; Albert Gjedde
Glucagon-like peptide-1 inhibits blood-brain glucose transfer in humans.
Diabetes 2008;57(2):325-31.
2008: Ida B Gottschalck; Palle B Jeppesen; Bolette Hartmann; Jens J Holst; Dennis B Henriksen
Effects of treatment with glucagon-like peptide-2 on bone resorption in colectomized patients with distal ileostomy or jejunostomy and short-bowel syndrome.
Scandinavian journal of gastroenterology 2008;43(11):1304-10.
2008: Anja W Dynesen; Allan Bardow; Arne Astrup; Birgit Petersson; Jens J Holst; Birgitte Nauntofte
Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa.
The American journal of clinical nutrition 2008;87(1):12-22.
2008: Harish Amin; Jens J Holst; Bolette Hartmann; Laurie Wallace; Jim Wright; David L Sigalet
Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate.
Pediatrics 2008;121(1):e180-6.
2008: Prue M Pereira-Fantini; Eva S Nagy; Sarah L Thomas; Russell G Taylor; Magdy Sourial; Monique C J Paris; Jens J Holst; Peter J Fuller; Julie E Bines
GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome.
Journal of pediatric gastroenterology and nutrition 2008;46(1):20-8.
2008: Carolyn F Deacon; Richard D Carr; Jens J Holst
DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes.
Frontiers in bioscience : a journal and virtual library 2008;13():1780-94.
2008: Julio Rosenstock; James Foley; Marc Rendell; Mona Landin-Olsson; Jens J Holst; Carolyn F Deacon; Erika Rochotte; Michelle A Baron
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.
Diabetes care 2008;31(1):30-5.
2008: Kristina M Utzschneider; Jenny Tong; Brenda Montgomery; Jayalakshmi Udayasankar; Fernando Gerchman; Santica M Marcovina; Catherine E Watson; Monica A Ligueros-Saylan; James Foley; Jens J Holst; Carolyn F Deacon; Steven E Kahn
The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose.
Diabetes care 2008;31(1):108-13.
2007: Filip K Knop; Tina Vilsbøll; Patricia V Højberg; Steen Larsen; Sten Madsbad; Jens J Holst; Thure Krarup
The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Regulatory peptides 2007;144(1-3):123-30.
2007: Per T Sangild; Christiane Malo; Mette Schmidt; Yvette M Petersen; Jan Elnif; Jens J Holst; Randal K Buddington
Glucagon-like peptide 2 has limited efficacy to increase nutrient absorption in fetal and preterm pigs.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(6):R2179-84.
2007: Paula L McClean; Nigel Irwin; Roslyn S Cassidy; Jens J Holst; Victor A Gault; Peter R Flatt
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1746-55.
2007: Andrea El-Ouaghlidi; Erika Rehring; Jens J Holst; Anja Schweizer; James Foley; David Holmes; Michael A Nauck
The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion.
The Journal of clinical endocrinology and metabolism 2007;92(11):4165-71.
2007: Dirk Hagemann; Jens J Holst; Arnica Gethmann; Matthias Banasch; Wolfgang E Schmidt; Juris J Meier
Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion.
Regulatory peptides 2007;143(1-3):64-8.
2007: Min Teng; Michael D Johnson; Christine Thomas; Dan Kiel; James Lakis; Tim Kercher; Shelley Aytes; Jarek Kostrowicki; Dilip Bhumralkar; Larry Truesdale; John May; Ulla Sidelman; Janos T Kodra; Anker Steen Jørgensen; Preben Olesen; Johannes Cornelis de Jong; Peter Madsen; Carsten Behrens; Ingrid Pettersson; Lotte Bjerre Knudsen; Jens J Holst; Jesper Lau
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Bioorganic & medicinal chemistry letters 2007;17(19):5472-8.
2007: Patrice Cani; Jens J Holst; Daniel J Drucker; Nathalie M Delzenne; Bernard Thorens; Rémy Burcelin; Claude Knauf
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
Molecular and cellular endocrinology 2007;276(1-2):18-23.
2007: Juris J Meier; Jens J Holst; Wolfgang E Schmidt; Michael A Nauck
Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans.
American journal of physiology. Endocrinology and metabolism 2007;293(3):E849-56.
2007: Sven Pörksen; Lotte B Nielsen; Anne Kaas; Mirjana Kocova; Francesco Chiarelli; Cathrine Orskov; Jens J Holst; Kenneth Beri Ploug; Philip Hougaard; Lars Hansen; Henrik B Mortensen
Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(8):2910-6.
2007: Filip K Knop; Tina Vilsbøll; Patricia V Højberg; Steen Larsen; Sten Madsbad; Aage Voelund; Jens J Holst; Thure Krarup
Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Diabetes 2007;56(8):1951-9.
2007: Jens J Holst; Bolette Hartmann; Ida B Gottschalck; Palle Bekker Jeppesen; Johannes Miholic; Dennis Bang Henriksen
Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate.
Scandinavian journal of gastroenterology 2007;42(7):814-20.
2007: Lotte Simonsen; Sofie Pilgaard; Cathrine Orskov; Mette M Rosenkilde; Bolette Hartmann; Jens J Holst; Carolyn F Deacon
Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G288-95.
2007: David L Sigalet; Laurie E Wallace; Jens J Holst; Gary R Martin; Tatsuru Kaji; Hiroaki Tanaka; Keith Sharkey
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G211-21.
2007: Lotte B Nielsen; Kenneth Beri Ploug; P G F Swift; Cathrine Ørskov; Inger Jansen-Olesen; Francesco Chiarelli; Jens J Holst; Philip Hougaard; Sven Pörksen; Reinhard W Holl; Carine de Beaufort; Steen Gammeltoft; Patrik Rorsman; Henrik B Mortensen; Lars Hansen
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156(6):663-71.
2007: Peter Staehr; Ole Hother-Nielsen; Henning Beck-Nielsen; Michael Roden; Harald Stingl; Jens J Holst; Paul K Jones; Visvanathan Chandramouli; Bernard R Landau
Hepatic autoregulation: response of glucose production and gluconeogenesis to increased glycogenolysis.
American journal of physiology. Endocrinology and metabolism 2007;292(5):E1265-9.
2007: Mikael Nilsson; Jens J Holst; Inger Me Björck
Metabolic effects of amino acid mixtures and whey protein in healthy subjects: studies using glucose-equivalent drinks.
The American journal of clinical nutrition 2007;85(4):996-1004.
2007: C Lawrence Kien; Ruth Blauwiekel; Janice Y Bunn; Thomas L Jetton; Wendy L Frankel; Jens J Holst
Cecal infusion of butyrate increases intestinal cell proliferation in piglets.
The Journal of nutrition 2007;137(4):916-22.
2007: Bogdan Balas; Muhammad R Baig; Catherine Watson; Beth E Dunning; Monica Ligueros-Saylan; Yibin Wang; Yan-Ling He; Celia Darland; Jens J Holst; Carolyn F Deacon; Kenneth Cusi; Andrea Mari; James Foley; Ralph DeFronzo
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2007;92(4):1249-55.
2007: Dennis B Henriksen; Peter Alexandersen; Bolette Hartmann; Charlotte L Adrian; Inger Byrjalsen; Henry G Bone; Jens J Holst; Claus Christiansen
Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women.
Bone 2007;40(3):723-9.
2007: Jocelyn de Heer; Jens J Holst
Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1.
Diabetes 2007;56(2):438-43.
2007: Johannes Miholic; Martha Hoffmann; Jens J Holst; Johannes Lenglinger; Martina Mittlböck; Helmar Bergmann; Georg Stacher
Gastric emptying of glucose solution and associated plasma concentrations of GLP-1, GIP, and PYY before and after fundoplication.
Surgical endoscopy 2007;21(2):309-14.
2007: Lene Hansen; Kristine Juul Hare; Bolette Hartmann; Carolyn F Deacon; Randi Ugleholdt; Astrid Plamboeck; Jens J Holst
Metabolism of glucagon-like peptide-2 in pigs: role of dipeptidyl peptidase IV.
Regulatory peptides 2007;138(2-3):126-32.
2007: Lotte Bjerre Knudsen; Dan Kiel; Min Teng; Carsten Behrens; Dilip Bhumralkar; Janos T Kodra; Jens J Holst; Claus B Jeppesen; Michael D Johnson; Johannes Cornelis de Jong; Anker Steen Jorgensen; Tim Kercher; Jarek Kostrowicki; Peter Madsen; Preben Olesen; Jacob S Petersen; Fritz Poulsen; Ulla G Sidelmann; Jeppe Sturis; Larry Truesdale; John May; Jesper Lau
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):937-42.
2007: Yan-Ling He; Denise Serra; Yibin Wang; Joelle Campestrini; Gilles-Jacques Riviere; Carolyn F Deacon; Jens J Holst; Sherwyn Schwartz; Jace C Nielsen; Monica Ligueros-Saylan
Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus.
Clinical pharmacokinetics 2007;46(7):577-88.
2007: Susan Bodé; Bolette Hartmann; Jens J Holst; Gorm Greisen
Glucagon-like peptide-2 in umbilical cord blood from mature infants.
Neonatology 2007;91(1):49-53.
2007: Carl Frederik Nagell; Jan F Pedersen; Jens J Holst
The antagonistic metabolite of GLP-1, GLP-1 (9-36)amide, does not influence gastric emptying and hunger sensations in man.
Scandinavian journal of gastroenterology 2007;42(1):28-33.
2007: Filip K Knop; Tina Vilsbøll; Steen Larsen; Patricia V Højberg; Aage Voelund; Sten Madsbad; Jens J Holst; Thure Krarup
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E324-30.
2006: Matthias Banasch; Kerem Bulut; Dirk Hagemann; Henning Schrader; Jens J Holst; Wolfgang E Schmidt; Juris J Meier
Glucagon-like peptide 2 inhibits ghrelin secretion in humans.
Regulatory peptides 2006;137(3):173-8.
2006: Anne Flint; Bente K Møller; Anne Raben; Birgitte Sloth; Dorthe Pedersen; Inge Tetens; Jens J Holst; Arne Astrup
Glycemic and insulinemic responses as determinants of appetite in humans.
The American journal of clinical nutrition 2006;84(6):1365-73.
2006: Elza Muscelli; Andrea Mari; Andrea Natali; Brenno Astiarraga; Stefania Camastra; Silvia Frascerra; Jens J Holst; Ele Ferrannini
Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance.
American journal of physiology. Endocrinology and metabolism 2006;291(6):E1144-50.
2006: Xiaowen Liu; David W Nelson; Jens J Holst; Denise M Ney
Synergistic effect of supplemental enteral nutrients and exogenous glucagon-like peptide 2 on intestinal adaptation in a rat model of short bowel syndrome.
The American journal of clinical nutrition 2006;84(5):1142-50.
2006: Martin O. Weickert; Joachim Spranger; Jens J Holst; Bärbel Otto; Corinna Koebnick; Matthias Möhlig; Andreas F H Pfeiffer
Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety.
The British journal of nutrition 2006;96(5):795-8.
2006: David W Nelson; Xiaowen Liu; Jens J Holst; Helen E Raybould; Denise M Ney
Vagal afferents are essential for maximal resection-induced intestinal adaptive growth in orally fed rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(5):R1256-64.
2006: Gary A Herman; Arthur Bergman; Cathy Stevens; Paul Kotey; Bingming Yi; Peng Zhao; Bruno Dietrich; George Golor; Andreas Schrodter; Bart Keymeulen; Kenneth C Lasseter; Mark S Kipnes; Karen Snyder; Deborah Hilliard; Michael Tanen; Caroline Cilissen; Marina De Smet; Inge De Lepeleire; Kristien van Dyck; Amy Qiu Wang; Wei Zeng; Michael J Davies; Wesley Tanaka; Jens J Holst; Carolyn F Deacon; Keith M Gottesdiener; John A Wagner
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(11):4612-9.
2006: Carolyn F Deacon; Astrid Plamboeck; Mette M Rosenkilde; Jocelyn de Heer; Jens J Holst
GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E468-75.
2006: Ewan R Pearson; Isabelle Flechtner; Pål R Njølstad; Maciej T Malecki; Sarah Flanagan; Brian Larkin; Frances M Ashcroft; Iwar Klimes; Ethel Codner; Violeta Iotova; Annabelle S Slingerland; Julian P H Shield; Jean-Jacques Robert; Jens J Holst; Penny M Clark; Sian Ellard; Oddmund Søvik; Michel Polak; Andrew T Hattersley
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
The New England journal of medicine 2006;355(5):467-77.
2006: Renate E Wachters-Hagedoorn; Marion G Priebe; Janneke A J Heimweg; A Marius Heiner; Klaus N Englyst; Jens J Holst; Frans Stellaard; roel vonk
The rate of intestinal glucose absorption is correlated with plasma glucose-dependent insulinotropic polypeptide concentrations in healthy men.
The Journal of nutrition 2006;136(6):1511-6.
2006: Juris J Meier; Arnica Gethmann; Michael A Nauck; Oliver Götze; Frank Schmitz; Carolyn F Deacon; Baptist Gallwitz; Wolfgang E Schmidt; Jens J Holst
The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.
American journal of physiology. Endocrinology and metabolism 2006;290(6):E1118-23.
2006: Per T Sangild; Richard H Siggers; Mette Schmidt; Jan Elnif; Charlotte R Bjornvad; Thomas Thymann; Marie L Grondahl; Axel K Hansen; Søren K Jensen; Mette Boye; Lars Moelbak; Randal K Buddington; Björn Weström; Jens J Holst; Douglas G Burrin
Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs.
Gastroenterology 2006;130(6):1776-92.
2006: Benjamin Buemann; Arne Astrup; Oluf Pedersen; Eva Black; Claus Holst; Søren Toubro; Søren M Echwald; Jens J Holst; C Rasmussen; Thorkild I A Sørensen
Possible role of adiponectin and insulin sensitivity in mediating the favorable effects of lower body fat mass on blood lipids.
The Journal of clinical endocrinology and metabolism 2006;91(5):1698-704.
2006: Randi Ugleholdt; Marie-Louise H Poulsen; Peter J Holst; Jean-Claude Irminger; Cathrine Orskov; Jens Pedersen; Mette M Rosenkilde; Xiaorong Zhu; Donald F Steiner; Jens J Holst
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
The Journal of biological chemistry 2006;281(16):11050-7.
2006: Juris J Meier; Michael A Nauck; Bartholomaeus Kask; Jens J Holst; Carolyn F Deacon; Wolfgang E Schmidt; Baptist Gallwitz
Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.
World journal of gastroenterology : WJG 2006;12(12):1874-80.
2006: Wendy A M Blom; Anne Lluch; Annette Stafleu; Sophie Vinoy; Jens J Holst; Gertjan Schaafsma; Henk F.J. Hendriks
Effect of a high-protein breakfast on the postprandial ghrelin response.
The American journal of clinical nutrition 2006;83(2):211-20.
2006: Wendy A M Blom; Anne Lluch; Sophie Vinoy; Annette Stafleu; Robin van den Berg; Jens J Holst; Frans J Kok; Henk F.J. Hendriks
Effects of gastric emptying on the postprandial ghrelin response.
American journal of physiology. Endocrinology and metabolism 2006;290(2):E389-95.
2006: Xinfu Guan; Heidi E Karpen; John Stephens; John T Bukowski; Sanyong Niu; Guangcheng Zhang; Barbara Stoll; Milton J Finegold; Jens J Holst; Darryl L Hadsell; Darry L Hadsell; Buford L Nichols; Douglas G Burrin
GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.
Gastroenterology 2006;130(1):150-64.
2006: Juris J Meier; Michael A Nauck; Andrea Pott; Kai Heinze; Oliver Goetze; Kerem Bulut; Wolfgang E Schmidt; Baptist Gallwitz; Jens J Holst
Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans.
Gastroenterology 2006;130(1):44-54.
2006: Barbara Stoll; Pamela T Price; Peter J Reeds; Xiaoyan Chang; Josef F Henry; Johannes B Van Goudoever; Jens J Holst; Douglas G Burrin
Feeding an elemental diet vs a milk-based formula does not decrease intestinal mucosal growth in infant pigs.
JPEN. Journal of parenteral and enteral nutrition 2006;30(1):32-9.
2006: Carolyn F Deacon; Jens J Holst
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.
The international journal of biochemistry & cell biology 2006;38(5-6):831-44.
2005: Frauke Fehse; Michael Trautmann; Jens J Holst; Amy E Halseth; Nuwan Nanayakkara; Loretta L Nielsen; Mark S Fineman; Dennis D Kim; Michael A Nauck
Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(11):5991-7.
2005: Anne Flint; Bente K Møller; Anne Raben; Inge Tetens; Jens J Holst; Arne Astrup
The use of glycaemic index tables to predict glycaemic index of breakfast meals.
The British journal of nutrition 2005;94(1):135-6.
2005: Signe S Torekov; Lesli H Larsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Jens J Holst; Ole D Madsen; Torben Hansen; Oluf Pedersen
Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.
Diabetes 2005;54(7):2261-5.
2005: Juris J Meier; Guido Kemmeries; Jens J Holst; Michael A Nauck
Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects.
Diabetes 2005;54(7):2212-8.
2005: Benjamin Buemann; Thorkild I A Sørensen; Oluf Pedersen; Eva Black; Claus Holst; Søren Toubro; Søren M Echwald; Jens J Holst; C Rasmussen; Arne Astrup
Lower-body fat mass as an independent marker of insulin sensitivity--the role of adiponectin.
International journal of obesity (2005) 2005;29(6):624-31.
2005: Gary R Martin; Laurie E Wallace; B Hartmann; Jens J Holst; L Demchyshyn; K Toney; David L Sigalet
Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(3):G431-8.
2005: Peter T Schmidt; Tryggve Ljung; Bolette Hartmann; Kristine J Hare; Jens J Holst; Per M Hellström
Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY.
European journal of gastroenterology & hepatology 2005;17(2):207-12.
2005: Douglas G Burrin; Barbara Stoll; Xinfu Guan; Liwei Cui; Xiaoyan Chang; Jens J Holst
Glucagon-like peptide 2 dose-dependently activates intestinal cell survival and proliferation in neonatal piglets.
Endocrinology 2005;146(1):22-32.
2004: Juris J Meier; Baptist Gallwitz; Bartholomaeus Kask; Carolyn F Deacon; Jens J Holst; Wolfgang E Schmidt; Michael A Nauck
Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.
Diabetes 2004;53 Suppl 3():S220-4.
2004: Michael A Nauck; Andrea El-Ouaghlidi; Bartholomäus Gabrys; Katrin Hücking; Jens J Holst; Carolyn F Deacon; Baptist Gallwitz; Wolfgang E Schmidt; Juris J Meier
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.
Regulatory peptides 2004;122(3):209-17.
2004: Mikael Nilsson; Marianne Stenberg; Anders H Frid; Jens J Holst; Inger M E Björck
Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins.
The American journal of clinical nutrition 2004;80(5):1246-53.
2004: Lene Hansen; Sarah Lampert; Hitoshi Mineo; Jens J Holst
Neural regulation of glucagon-like peptide-1 secretion in pigs.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E939-47.
2004: Monique C J Paris; Peter J Fuller; Bendix Carstensen; Eva Nagy; Russell G Taylor; Magdy Sourial; Jens J Holst; Bolette Hartmann; Julie E Binesm
Plasma GLP-2 levels and intestinal markers in the juvenile pig during intestinal adaptation: effects of different diet regimens.
Digestive diseases and sciences 2004;49(10):1688-95.
2004: Eva Degerman; Vincent C Manganiello; Jens J Holst; Bo Ahrén
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
European journal of pharmacology 2004;498(1-3):319-23.
2004: Carolyn F Deacon; Bo Ahrén; Jens J Holst
Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Expert opinion on investigational drugs 2004;13(9):1091-102.
2004: David L Sigalet; Gary Martin; Jonathan B Meddings; Bolette Hartman; Jens J Holst
GLP-2 levels in infants with intestinal dysfunction.
Pediatric research 2004;56(3):371-6.
2004: Ramona Trebbien; Letty Klarskov; Mette Olesen; Jens J Holst; Richard D Carr; Carolyn F Deacon
Neutral endopeptidase 24.11 is important for the degradation of both endogenous and exogenous glucagon in anesthetized pigs.
American journal of physiology. Endocrinology and metabolism 2004;287(3):E431-8.
2004: Anne L Bartholome; David M Albin; David H Baker; Jens J Holst; Kelly Tappenden
Supplementation of total parenteral nutrition with butyrate acutely increases structural aspects of intestinal adaptation after an 80% jejunoileal resection in neonatal piglets.
JPEN. Journal of parenteral and enteral nutrition 2004;28(4):210-22; discussion 222-3.
2004: Anne Flint; Bente K Møller; Anne Raben; Dorthe Pedersen; Inge Tetens; Jens J Holst; Arne Astrup
The use of glycaemic index tables to predict glycaemic index of composite breakfast meals.
The British journal of nutrition 2004;91(6):979-89.
2004: Harri Niinikoski; Barbara Stoll; Xinfu Guan; Ketan Kansagra; Barry D Lambert; John Stephens; Bolette Hartmann; Jens J Holst; Douglas G Burrin
Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets.
The Journal of nutrition 2004;134(6):1467-74.
2004: J A L Calbet; Jens J Holst
Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans.
European journal of nutrition 2004;43(3):127-39.
2004: Tanya Hansotia; Laurie L Baggio; Dominique Delmeire; Simon Hinke; Yuichiro Yamada; Katsushi Tsukiyama; Yutaka Seino; Jens J Holst; Frans Schuit; Daniel J Drucker
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.
Diabetes 2004;53(5):1326-35.
2004: Michael A Nauck; Jörg Walberg; Arndt Vethacke; Andrea El-Ouaghlidi; Metin Senkal; Jens J Holst; Baptist Gallwitz; J Baptist Gallwitz; Wolfgang E Schmidt; Wolff Schmiegel
Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like peptide 1.
Regulatory peptides 2004;118(1-2):89-97.
2004: Lene Hansen; Bolette Hartmann; Hitoshi Mineo; Jens J Holst
Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum.
Regulatory peptides 2004;118(1-2):11-8.
2004: Juris J Meier; Oliver Goetze; Jens Anstipp; Dirk Hagemann; Jens J Holst; Wolfgang E Schmidt; Baptist Gallwitz; Michael A Nauck
Gastric inhibitory polypeptide does not inhibit gastric emptying in humans.
American journal of physiology. Endocrinology and metabolism 2004;286(4):E621-5.
2004: Juris J Meier; Dirk Weyhe; Mark Michaely; Metin Senkal; Volker Zumtobel; Michael A Nauck; Jens J Holst; Wolfgang E Schmidt; Baptist Gallwitz
Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes.
Critical care medicine 2004;32(3):848-51.
2004: Juris J Meier; Michael A Nauck; Daniel Kranz; Jens J Holst; Carolyn F Deacon; Dirk Gaeckler; Wolfgang E Schmidt; Baptist Gallwitz
Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
Diabetes 2004;53(3):654-62.
2004: Randi Ugleholdt; Xiaorong Zhu; Carolyn F Deacon; Cathrine Ørskov; Donald F Steiner; Jens J Holst
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Endocrinology 2004;145(3):1349-55.
2004: Marian Dalgaard; Claus Thomsen; Birthe M Rasmussen; Jens J Holst; Kjeld Hermansen
Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients.
Metabolism: clinical and experimental 2004;53(1):77-83.
2004: Søren Gregersen; Per Bendix Jeppesen; Jens J Holst; Kjeld Hermansen
Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Metabolism: clinical and experimental 2004;53(1):73-6.
2003: Dennis B Henriksen; Peter Alexandersen; Nina H Bjarnason; Tina Vilsbøll; Bolette Hartmann; Eva E G Henriksen; Inger Byrjalsen; Thure Krarup; Jens J Holst; Claus Christiansen
Role of gastrointestinal hormones in postprandial reduction of bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(12):2180-9.
2003: Juris J Meier; Michael A Nauck; Nina Siepmann; Michael Greulich; Jens J Holst; Carolyn F Deacon; Wolfgang E Schmidt; Baptist Gallwitz
Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.
Metabolism: clinical and experimental 2003;52(12):1579-85.
2003: Robert S Jackson; John W M Creemers; I Sadaf Farooqi; Marie-Laure Raffin-Sanson; Andrea Varro; Graham J Dockray; Jens J Holst; Patricia L Brubaker; Pierre Corvol; Kenneth S Polonsky; Diane Ostrega; Kenneth L Becker; Xavier Bertagna; John C Hutton; Anne White; Mehul T Dattani; Khalid Hussain; Stephen J Middleton; Thomasina M Nicole; Peter J Milla; Keith J Lindley; Stephen O'Rahilly
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
The Journal of clinical investigation 2003;112(10):1550-60.
2003: Katri S Juntunen; David E Laaksonen; Karin Autio; Leo Niskanen; Jens J Holst; Kari E Savolainen; Kirsi-Helena Liukkonen; Kaisa S Poutanen; Hannu M Mykkänen
Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread.
The American journal of clinical nutrition 2003;78(5):957-64.
2003: Bo Ahrén; Jens J Holst; Andrea Mari
Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans.
Diabetes care 2003;26(10):2860-4.
2003: Filip K Knop; Tina Vilsbøll; Steen Larsen; Sten Madsbad; Jens J Holst; Thure Krarup
No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis.
Diabetes care 2003;26(9):2581-7.
2003: Carolyn F Deacon; Mette Kelstrup; Ramona Trebbien; Letty Klarskov; Mette Olesen; Jens J Holst
Differential regional metabolism of glucagon in anesthetized pigs.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E552-60.
2003: Tina Vilsbøll; Thure Krarup; Sten Madsbad; Jens J Holst
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects.
Regulatory peptides 2003;114(2-3):115-21.
2003: Xinfu Guan; Barbara Stoll; Xiaofeng Lu; Kelly Tappenden; Jens J Holst; Bolette Hartmann; Douglas G Burrin
GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1.
Gastroenterology 2003;125(1):136-47.
2003: Christine B Jensen; Heidi Storgaard; Jens J Holst; Flemming Dela; Sten Madsbad; Allan Vaag
Insulin secretion and cellular glucose metabolism after prolonged low-grade intralipid infusion in young men.
The Journal of clinical endocrinology and metabolism 2003;88(6):2775-83.
2003: Juris J Meier; Baptist Gallwitz; Stefan Salmen; Oliver Goetze; Jens J Holst; Wolfgang E Schmidt; Michael A Nauck
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(6):2719-25.
2003: Yvette M Petersen; Bolette Hartmann; Jens J Holst; Isabelle Le Huerou-Luron; Charlotte R Bjørnvad; Per T Sangild
Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development.
The Journal of nutrition 2003;133(6):1781-6.
2003: Juris J Meier; Baptist Gallwitz; Nina Siepmann; Jens J Holst; Carolyn F Deacon; Wolfgang E Schmidt; Michael A Nauck
The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).
Regulatory peptides 2003;113(1-3):95-100.
2003: Elizabeth M Dahly; Melanie B Gillingham; Ziwen Guo; Sangita G Murali; David W Nelson; Jens J Holst; Denise M Ney
Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(4):G670-82.
2003: Claus Thomsen; Hanne Storm; Jens J Holst; Kjeld Hermansen
Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes.
The American journal of clinical nutrition 2003;77(3):605-11.
2003: Lise L Kjems; Jens J Holst; Aage Voelund; Sten Madsbad
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects.
Diabetes 2003;52(2):380-6.
2003: Astrid Plamboeck; Jens J Holst; Richard D Carr; Carolyn F Deacon
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.
Advances in experimental medicine and biology 2003;524():303-12.
2003: Anne Raben; Lisa Agerholm-Larsen; Anne Flint; Jens J Holst; Arne Astrup
Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake.
The American journal of clinical nutrition 2003;77(1):91-100.
2002: Lene Hansen; Jens J Holst
The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?
Regulatory peptides 2002;110(1):39-45.
2002: Xiaorong Zhu; An Zhou; Arunangsu Dey; Christina Norrbom; Raymond Carroll; Chunling Zhang; Virginie Laurent; Iris Lindberg; Randi Ugleholdt; Jens J Holst; Donald F Steiner
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10293-8.
2002: Carolyn F Deacon; Jens J Holst
Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Biochemical and biophysical research communications 2002;294(1):1-4.
2002: Carolyn F Deacon; Astrid Plamboeck; Søren Møller; Jens J Holst
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E873-9.
2002: Michael A Nauck; Markus M Heimesaat; Kai Behle; Jens J Holst; Markus S Nauck; Robert A Ritzel; Michael Hüfner; Wolff Schmiegel
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers.
The Journal of clinical endocrinology and metabolism 2002;87(3):1239-46.
2002: Asa Johansson; Tommy Olsson; Kristina Cederquist; Hakan Forsberg; Jens J Holst; Jonathan R Seckl; Bo Ahren
Abnormal release of incretins and cortisol after oral glucose in subjects with insulin-resistant myotonic dystrophy.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(3):397-405.
2002: Katri S Juntunen; Leo Niskanen; Kirsi-Helena Liukkonen; Kaisa S Poutanen; Jens J Holst; Hannu M Mykkänen
Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects.
The American journal of clinical nutrition 2002;75(2):254-62.
2002: Jens J Holst
Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2002;16(3):175-81.
2001: Eva Rask; Tommy Olsson; Siv Söderberg; Owe Johnson; J Seckl; Jens J Holst; Bo Ahrén
Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.
Diabetes care 2001;24(9):1640-5.
2001: Anne Flint; Anne Raben; A K Ersbøll; Jens J Holst; Arne Astrup
The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(6):781-92.
2001: Johannes B Van Goudoever; Barbara Stoll; Bolette Hartmann; Jens J Holst; Peter J Reeds; Douglas G Burrin
Secretion of trophic gut peptides is not different in bolus- and continuously fed piglets.
The Journal of nutrition 2001;131(3):729-32.
2001: Anne Raben; Jens J Holst; J Madsen; Arne Astrup
Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women.
The American journal of clinical nutrition 2001;73(2):177-89.
2000: Douglas G Burrin; Barbara Stoll; R Jiang; Yvette M Petersen; Jan Elnif; Randal K Buddington; Mette Schmidt; Jens J Holst; Bolette Hartmann; Per T Sangild
GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis.
American journal of physiology. Gastrointestinal and liver physiology 2000;279(6):G1249-56.
2000: Douglas G Burrin; Barbara Stoll; R Jiang; Xiaoyan Chang; Bolette Hartmann; Jens J Holst; G H Greeley; Peter J Reeds
Minimal enteral nutrient requirements for intestinal growth in neonatal piglets: how much is enough?
The American journal of clinical nutrition 2000;71(6):1603-10.
2000: Anne Flint; Anne Raben; J F Rehfeld; Jens J Holst; Arne Astrup
The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(3):288-98.
1999: Jens J Holst
Treatment of Type 2 diabetes mellitus based on glucagon-like peptide-1.
Expert opinion on investigational drugs 1999;8(9):1409-15.
1999: Ursula Plöckinger; Jens J Holst; D Messerschmidt; Werner Hopfenmüller; Hans-Jürgen Quabbe
Octreotide suppresses the incretin glucagon-like peptide (7-36) amide in patients with acromegaly or clinically nonfunctioning pituitary tumors and in healthy subjects.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):538-44.
1999: C Thomsen; Ole Winther Rasmussen; T Lousen; Jens J Holst; S Fenselau; Jürgen Schrezenmeir; Kjeld Hermansen
Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects.
The American journal of clinical nutrition 1999;69(6):1135-43.
1998: Anne Flint; Anne Raben; Arne Astrup; Jens J Holst
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
The Journal of clinical investigation 1998;101(3):515-20.
1997: M Furuta; H Yano; An Zhou; Yves Rouillé; Jens J Holst; Raymond Carroll; Mariella Ravazzola; Lelio Orci; H Furuta; Donald F Steiner
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6646-51.