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Jeffrey Holt

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Yoshiyuki Kawashima; Kiyoto Kurima; Valentina Labay; Andrea Lelli; Tomoko Makishima; Doris K Wu; Yukako Asai; Charles C Della Santina; Gwenaelle Geleoc; Jeffrey R Holt; Andrew J Griffith
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.
Geoffrey C Horwitz; Sherri M Jones; Jessica R Risner-Janiczek; Jeffrey R Holt
HCN channels expressed in the inner ear are necessary for normal balance function.
Katherine A Steigelman; Claas Wodarczyk; Xudong Wu; Alessandra Boletta; Jiangang Gao; Gwenaelle Geleoc; Gregory G Germino; Jeffrey R Holt; Hyunho Kim; Andrea Lelli; Susan Lin; Klaus B Piontek; Feng Qian; Jian Zuo
Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.

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All Publications

2011: Yoshiyuki Kawashima; Kiyoto Kurima; Valentina Labay; Andrea Lelli; Tomoko Makishima; Doris K Wu; Yukako Asai; Charles C Della Santina; Gwenaelle Geleoc; Jeffrey R Holt; Andrew J Griffith
Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes.
The Journal of clinical investigation 2011;121(12):4796-809.
2011: Geoffrey C Horwitz; Sherri M Jones; Jessica R Risner-Janiczek; Jeffrey R Holt
HCN channels expressed in the inner ear are necessary for normal balance function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(46):16814-25.
2011: Katherine A Steigelman; Claas Wodarczyk; Xudong Wu; Alessandra Boletta; Jiangang Gao; Gwenaelle Geleoc; Gregory G Germino; Jeffrey R Holt; Hyunho Kim; Andrea Lelli; Susan Lin; Klaus B Piontek; Feng Qian; Jian Zuo
Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(34):12241-50.
2010: Andrea Lelli; Piotr Kazmierczak; Yoshiyuki Kawashima; Ulrich Müller; Jeffrey R Holt
Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(34):11259-69.
2010: Yukako Asai; Jeffrey R Holt; Gwenaelle Geleoc
A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.
Journal of the Association for Research in Otolaryngology : JARO 2010;11(1):27-37.
2010: Geoffrey C Horwitz; Andrea Lelli; Gwenaelle Geleoc; Jeffrey R Holt
HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.
PloS one 2010;5(1):e8627.
2009: Andrea Lelli; Yukako Asai; Andrew Forge; Jeffrey R Holt; Gwenaelle Geleoc
Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.
Journal of neurophysiology 2009;101(6):2961-73.
2009: Martin Schwander; Wei Xiong; Joshua Tokita; Andrea Lelli; Heather M Elledge; Piotr Kazmierczak; Anna Sczaniecka; Anand Kolatkar; Timothy Wiltshire; Peter Kuhn; Jeffrey R Holt; Anne E White-Olson; Lisa Tarantino; Ulrich Müller
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5252-7.
2009: Maria Sol Collado; Jeffrey R Holt
Can neurosphere production help restore inner ear transduction?
Proceedings of the National Academy of Sciences of the United States of America 2009;106(1):8-9.
2008: Bradley W Kesser; George T Hashisaki; Jeffrey R Holt
Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy.
The Laryngoscope 2008;118(5):821-31.
2007: Eric A Stauffer; Jeffrey R Holt
Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system.
Journal of neurophysiology 2007;98(6):3360-9.
2007: Jeffrey R Holt; Eric A Stauffer; David Abraham; Gwenaelle Geleoc
Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(33):8940-51.
2007: Bradley W Kesser; George T Hashisaki; K Fletcher; H Eppard; Jeffrey R Holt
An in vitro model system to study gene therapy in the human inner ear.
Gene therapy 2007;14(15):1121-31.
2007: Kazuo Oshima; Christian Grimm; C Eduardo Corrales; Pascal Senn; Rodrigo Martinez-Monedero; Gwenaelle Geleoc; Albert S B Edge; Jeffrey R Holt; Stefan Heller
Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.
Journal of the Association for Research in Otolaryngology : JARO 2007;8(1):18-31.
2006: Jessica R Risner; Jeffrey R Holt
Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons.
Journal of neurophysiology 2006;96(5):2364-76.
2006: Joann McGee; Richard J Goodyear; D Randy McMillan; Eric A Stauffer; Jeffrey R Holt; Kirsten G Locke; David G Birch; P Kevin Legan; Perrin C White; Edward J Walsh; Guy P Richardson
The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(24):6543-53.
2006: Mathias Senften; Martin Schwander; Piotr Kazmierczak; Concepcion Lillo; Jung-Bum Shin; Tama Hasson; Gwenaelle Geleoc; Peter G Gillespie; David Williams; Jeffrey R Holt; Ulrich Müller
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(7):2060-71.
2005: Eric A Stauffer; John D Scarborough; Moritoshi Hirono; Emilie Diane Miller; Kavita Shah; John A Mercer; Jeffrey R Holt; Peter G Gillespie
Fast adaptation in vestibular hair cells requires myosin-1c activity.
Neuron 2005;47(4):541-53.
2004: David P Corey; Jaime García-Añoveros; Jeffrey R Holt; Kelvin Y Kwan; Shuh-Yow Lin; Melissa A Vollrath; Andrea Amalfitano; Eunice L M Cheung; Bruce H Derfler; Anne Duggan; Gwenaelle Geleoc; Paul A Gray; Matthew P Hoffman; Heidi L Rehm; Daniel Tamasauskas; Duan-Sun Zhang
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells.
Nature 2004;432(7018):723-30.
2004: Gwenaelle Geleoc; Jessica R Risner; Jeffrey R Holt
Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(49):11148-59.
2003: Gwenaelle Geleoc; Jeffrey R Holt
Developmental acquisition of sensory transduction in hair cells of the mouse inner ear.
Nature neuroscience 2003;6(10):1019-20.
2003: J Chris Colclasure; Jeffrey R Holt
Transduction and adaptation in sensory hair cells of the mammalian vestibular system.
Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology 2003;16(2):61-70.
2003: Gwenaelle Geleoc; Jeffrey R Holt
Auditory amplification: outer hair cells pres the issue.
Trends in neurosciences 2003;26(3):115-7.
2002: Rachel A Dumont; Yi-Dong Zhao; Jeffrey R Holt; Martin Bähler; Peter G Gillespie
Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.
Journal of the Association for Research in Otolaryngology : JARO 2002;3(4):375-89.
2002: Jeffrey R Holt
Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear.
Audiology & neuro-otology 2002;7(3):157-60.
2002: Jeffrey R Holt; Susan K H Gillespie; David Provance, Jr.; Kavita Shah; Kevan M Shokat; David P Corey; John A Mercer; Peter G Gillespie
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.
Cell 2002;108(3):371-81.
2001: Peter G Gillespie; J P Albanesi; M Bahler; William M Bement; Jonathan S Berg; D R Burgess; B Burnside; Richard E Cheney; David P Corey; E Coudrier; Primal De Lanerolle; John A Hammer; Tama Hasson; Jeffrey R Holt; A J Hudspeth; M Ikebe; J Kendrick-Jones; Edward D Korn; R Li; John A Mercer; Ronald A Milligan; Mark S Mooseker; E Michael Ostap; C Petit; Thomas D Pollard; James R Sellers; T Soldati; M A Titus
Myosin-I nomenclature.
The Journal of cell biology 2001;155(5):703-4.
2000: Jeffrey R Holt; David P Corey
Two mechanisms for transducer adaptation in vertebrate hair cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11730-5.
2000: John S Oghalai; Jeffrey R Holt; Takashi Nakagawa; T M Jung; Newton J Coker; Herman A Jenkins; Ruth Anne Eatock; William E Brownell
Harvesting human hair cells.
The Annals of otology, rhinology, and laryngology 2000;109(1):9-16.
1999: Jeffrey R Holt; Melissa A Vollrath; Ruth Anne Eatock
Stimulus processing by type II hair cells in the mouse utricle.
Annals of the New York Academy of Sciences 1999;871():15-26.
1999: Jeffrey R Holt
Biology in pictures. A sense of colour.
Current biology : CB 1999;9(10):R351.
1999: Jeffrey R Holt; David C Johns; S Wang; Z Y Chen; R J Dunn; Eduardo Marban; David P Corey
Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors.
Journal of neurophysiology 1999;81(4):1881-8.
1999: Jeffrey R Holt; David P Corey
Ion channel defects in hereditary hearing loss.
Neuron 1999;22(2):217-9.
1998: John S Oghalai; Jeffrey R Holt; Takashi Nakagawa; T M Jung; Newton J Coker; Herman A Jenkins; Ruth Anne Eatock; William E Brownell
Ionic currents and electromotility in inner ear hair cells from humans.
Journal of neurophysiology 1998;79(4):2235-9.
1997: Jeffrey R Holt; David P Corey; Ruth Anne Eatock
Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(22):8739-48.
1995: Winfried Denk; Jeffrey R Holt; G M Shepherd; David P Corey
Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links.
Neuron 1995;15(6):1311-21.
1995: Jeffrey R Holt; Ruth Anne Eatock
Inwardly rectifying currents of saccular hair cells from the leopard frog.
Journal of neurophysiology 1995;73(4):1484-502.