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Patrick Holt

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William S Pomat; John C Reeder; Peter C Richmond; Peter Siba; Anita H J van den Biggelaar; Michael P Alpers; Jacinta Francis; Patrick G Holt; Peter Jacoby; Deborah Lehmann; Suparat Phuanukoonnon
Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial.
Joanne G Lisciandro; Marie G Nadal-Sims; William Pomat; Susan L Prescott; Peter C Richmond; Peter M Siba; Deborah H Strickland; Catherine J Devitt; Patrick G Holt; Anita H J van den Biggelaar
Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.
Patrick G Holt; Peter D Sly
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment.

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All Publications

2013: William S Pomat; John C Reeder; Peter C Richmond; Peter Siba; Anita H J van den Biggelaar; Michael P Alpers; Jacinta Francis; Patrick G Holt; Peter Jacoby; Deborah Lehmann; Suparat Phuanukoonnon
Safety and immunogenicity of neonatal pneumococcal conjugate vaccination in Papua New Guinean children: a randomised controlled trial.
PloS one 2013;8(2):e56698.
2012: Joanne G Lisciandro; Marie G Nadal-Sims; William Pomat; Susan L Prescott; Peter C Richmond; Peter M Siba; Deborah H Strickland; Catherine J Devitt; Patrick G Holt; Anita H J van den Biggelaar
Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions.
The Journal of allergy and clinical immunology 2012;130(5):1167-1174.e10.
2012: Patrick G Holt; Peter D Sly
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment.
Nature medicine 2012;18(5):726-35.
2012: Deborah H Strickland; Jennifer A Thomas; F Blank; Alexander N Larcombe; K L McKenna; D Mok; Peter David Sly; Patrick G Holt
Defective aeroallergen surveillance by airway mucosal dendritic cells as a determinant of risk for persistent airways hyper-responsiveness in experimental asthma.
Mucosal immunology 2012;5(3):332-41.
2012: Belinda J Hales; Tatjana K Heinrich; Patrick G Holt; Merci Kusel; Leigh J Pearce; Peter D Sly; Wendy-Anne Smith; Lee Ying Chai; Claire E Elliot; Guicheng Zhang; Wayne R Thomas
Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children.
Thorax 2012;67(4):321-7.
2012: Merci Kusel; Patrick G Holt; Sebastian L Johnston; Tatiana Kebadze; Peter David Sly
Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2012;39(4):876-82.
2012: Andrew J O Whitehouse; Barbara J Holt; Patrick G Holt; Merci Kusel; Michael Serralha; Prue H Hart
Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development.
Pediatrics 2012;129(3):485-93.
2012: Joanne G Lisciandro; Marie G Nadal-Sims; William Pomat; Susan L Prescott; Peter M Siba; Deborah Strickland; Catherine J Devitt; Patrick G Holt; Anita H J van den Biggelaar
Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2012;23(2):173-80.
2012: Anita H J van den Biggelaar; Selma P Wiertsema; Celestine Aho; Catherine J Devitt; Belinda J Hales; Patrick G Holt; Peter Jacoby; Audrey Michael; Tim Mitchell; Marie A Nadal-Sims; Suparat Phuanukoonnon; William S Pomat; Peter Richmond; Peter Siba; Wendy-Anne Smith; Deborah Lehmann
Effect of early carriage of Streptococcus pneumoniae on the development of pneumococcal protein-specific cellular immune responses in infancy.
The Pediatric infectious disease journal 2012;31(3):243-8.
2012: Olivia J White; Anthony Bosco; Anita H J van den Biggelaar; Katherine L McKenna; Peter Richmond; Patrick G Holt
A genomics-based approach to assessment of vaccine safety and immunogenicity in children.
Vaccine 2012;30(10):1865-74.
2012: Angela Rate; Anthony Bosco; Patrick G Holt; Kathy L McKenna; John W Upham
Airway epithelial cells condition dendritic cells to express multiple immune surveillance genes.
PloS one 2012;7(9):e44941.
2012: Joanne G Lisciandro; Marie G Nadal-Sims; William Pomat; Susan L Prescott; Peter Siba; Deborah Strickland; Meri C Tulic; Catherine J Devitt; Patrick G Holt; Anita H J van den Biggelaar
Ontogeny of Toll-like and NOD-like receptor-mediated innate immune responses in Papua New Guinean infants.
PloS one 2012;7(5):e36793.
2012: Paula T Cunningham; Claire E Elliot; Patrick G Holt; Andrew G Jarnicki; Alexander N Larcombe; Jason C Lenzo; Graeme R Zosky; Wayne R Thomas
Sensitizing and Th2 adjuvant activity of cysteine protease allergens.
International archives of allergy and immunology 2012;158(4):347-58.
2011: Elysia M Hollams; Barbara J Holt; N H de Klerk; P H Hart; F Parsons; Michael Serralha; Peter David Sly; Guicheng Zhang; Patrick G Holt
Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2011;38(6):1320-7.
2011: Vanessa S Fear; Patrick G Holt; Siew Ping Lai; Peter D Sly; Deborah S Strickland; Fabian Blank; Jennifer T Burchell; Debra J Turner; Christophe von Garnier; Matthew E Wikstrom; Philip A Stumbles
Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4561-70.
2011: Deborah H Strickland; Patrick G Holt
T regulatory cells in childhood asthma.
Trends in immunology 2011;32(9):420-7.
2011: Anita van den Biggelaar; Anthony Bosco; Catherine J Devitt; Deborah Lehmann; Marie A Nadal-Sims; Suparat Phuanukoonnon; William Pomat; Peter Richmond; Peter Siba; Patrick G Holt
Pneumococcal conjugate vaccination at birth in a high-risk setting: no evidence for neonatal T-cell tolerance.
Vaccine 2011;29(33):5414-20.
2011: Catherine M Hayden; Patrick G Holt; Parveenjeet K Judge; Siew-Kim Khoo; Ingrid A Laing; Stephen W Turner; Guicheng Zhang; Jack Goldblatt; Peter N Le Souëf
Regulatory role of IL10 genetic variations in determining allergen-induced T(H)2 cytokine responses in children.
The Journal of allergy and clinical immunology 2011;128(1):237-239.e8.
2011: Patrick G Holt; Peter David Sly
Interaction between adaptive and innate immune pathways in the pathogenesis of atopic asthma: operation of a lung/bone marrow axis.
Chest 2011;139(5):1165-71.
2011: Deborah H Strickland; S Judd; Jennifer A Thomas; Alexander N Larcombe; Peter David Sly; Patrick G Holt
Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control.
Mucosal immunology 2011;4(1):43-52.
2010: Deborah H Strickland; John W Upham; Patrick G Holt
Epithelial-dendritic cell interactions in allergic disorders.
Current opinion in immunology 2010;22(6):789-94.
2010: Catherine A Thornton; Trisha V Macfarlane; Patrick G Holt
The hygiene hypothesis revisited: role of materno-fetal interactions.
Current allergy and asthma reports 2010;10(6):444-52.
2010: Elysia M Hollams; B J Hales; C Bachert; W Huvenne; F Parsons; N H de Klerk; Michael Serralha; Barbara J Holt; Staffan Ahlstedt; W R Thomas; Peter David Sly; Patrick G Holt
Th2-associated immunity to bacteria in teenagers and susceptibility to asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;36(3):509-16.
2010: Matthew E Wikstrom; Eva Batanero; Samantha R Judd; Kristin Wiqvist; Patrick G Holt; Philip A Stumbles
Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes.
Immunology and cell biology 2010;88(6):658-66.
2010: Peter David Sly; Merci Kusel; Patrick G Holt
Do early-life viral infections cause asthma?
The Journal of allergy and clinical immunology 2010;125(6):1202-5.
2010: Patrick G Holt; Deborah H Strickland
Interactions between innate and adaptive immunity in asthma pathogenesis: new perspectives from studies on acute exacerbations.
The Journal of allergy and clinical immunology 2010;125(5):963-72; quiz 973-4.
2010: Anita van den Biggelaar; Patrick G Holt
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: neonatal immune function and vaccine responses in children born in low-income versus high-income countries.
Clinical and experimental immunology 2010;160(1):42-7.
2010: Patrick G Holt; Anita van den Biggelaar
99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: the role of infections in allergy: atopic asthma as a paradigm.
Clinical and experimental immunology 2010;160(1):22-6.
2010: Olivia J White; Julie Rowe; Peter Richmond; Helen Marshall; Peter McIntyre; Nicholas Wood; Patrick G Holt
Th2-polarisation of cellular immune memory to neonatal pertussis vaccination.
Vaccine 2010;28(14):2648-52.
2010: Patrick G Holt; Julie Rowe; Merci Kusel; Faith Parsons; Elysia M Hollams; Anthony Bosco; Kathy McKenna; Lily Subrata; Nicholas de Klerk; Michael Serralha; Barbara J Holt; Guicheng Zhang; Richard Loh; Staffan Ahlstedt; Peter David Sly
Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study.
The Journal of allergy and clinical immunology 2010;125(3):653-9, 659.e1-659.e7.
2010: Philip A Stumbles; Deborah H Strickland; Mathew E Wikstrom; Jennifer A Thomas; Christophe von Garnier; Patrick G Holt
Identification and isolation of rodent respiratory tract dendritic cells.
Methods in molecular biology (Clifton, N.J.) 2010;595():249-63.
2010: Marjut Roponen; Stephanie T Yerkovich; Elysia M Hollams; Peter David Sly; Patrick G Holt; John W Upham
Toll-like receptor 7 function is reduced in adolescents with asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2010;35(1):64-71.
2009: Patrick G Holt; Deborah H Strickland
Soothing signals: transplacental transmission of resistance to asthma and allergy.
The Journal of experimental medicine 2009;206(13):2861-4.
2009: Meri K Tulic; Peter David Sly; David Andrews; Maxine Crook; Francis Davoine; Solomon O Odemuyiwa; Adrian Charles; Megan L Hodder; Susan L Prescott; Patrick G Holt; Redwan Moqbel
Thymic indoleamine 2,3-dioxygenase-positive eosinophils in young children: potential role in maturation of the naive immune system.
The American journal of pathology 2009;175(5):2043-52.
2009: Jacinta P Francis; Peter Richmond; William S Pomat; Audrey Michael; Helen Keno; Suparat Phuanukoonnon; Jan B Nelson; Melissa Whinnen; Tatjana Heinrich; Wendy-Anne Smith; Susan L Prescott; Patrick G Holt; Peter Siba; Deborah Lehmann; Anita van den Biggelaar
Maternal antibodies to pneumolysin but not to pneumococcal surface protein A delay early pneumococcal carriage in high-risk Papua New Guinean infants.
Clinical and vaccine immunology : CVI 2009;16(11):1633-8.
2009: John W Upham; Guicheng Zhang; Angela Rate; Stephanie T Yerkovich; Merci Kusel; Peter David Sly; Patrick G Holt
Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing.
The Journal of allergy and clinical immunology 2009;124(4):707-13.e2.
2009: Elysia M Hollams; Marie Deverell; Michael Serralha; Devinda Suriyaarachchi; Faith Parsons; Guicheng Zhang; Nicholas de Klerk; Barbara J Holt; Claire Ladyman; Agata Sadowska; Julie Rowe; Richard Loh; Peter David Sly; Patrick G Holt
Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling.
The Journal of allergy and clinical immunology 2009;124(3):463-70, 470.e1-16.
2009: Anita van den Biggelaar; Susan L Prescott; Marjut Roponen; Marie A Nadal-Sims; Catherine J Devitt; Suparat Phuanukoonnon; William Pomat; Meri K Tulic; Deborah Lehmann; Peter Siba; Peter Richmond; Patrick G Holt
Neonatal innate cytokine responses to BCG controlling T-cell development vary between populations.
The Journal of allergy and clinical immunology 2009;124(3):544-50, 550.e1-2.
2009: Lily S Subrata; Joelene Bizzintino; Emilie Mamessier; Anthony Bosco; Katherine L McKenna; Matthew E Wikström; Jack Goldblatt; Peter David Sly; Belinda J Hales; Wayne R Thomas; Ingrid A Laing; Peter N LeSouëf; Patrick G Holt
Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2793-800.
2009: Graeme R Zosky; Alexander N Larcombe; Olivia J White; Jennifer T Burchell; Christophe von Garnier; Patrick G Holt; Debra J Turner; Matthew E Wikstrom; Peter David Sly; Philip A Stumbles
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways.
American journal of physiology. Lung cellular and molecular physiology 2009;297(2):L373-9.
2009: Patrick G Holt; Peter David Sly
Non-atopic intrinsic asthma and the 'family tree' of chronic respiratory disease syndromes.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(6):807-11.
2009: Anthony Bosco; Kathy L McKenna; Martin J Firth; Peter David Sly; Patrick G Holt
A network modeling approach to analysis of the Th2 memory responses underlying human atopic disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(10):6011-21.
2009: Anita van den Biggelaar; Peter Richmond; William S Pomat; Suparat Phuanukoonnon; Marie A Nadal-Sims; Catherine J Devitt; Peter Siba; Deborah Lehmann; Patrick G Holt
Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea.
Vaccine 2009;27(9):1340-7.
2009: Guicheng Zhang; Julie Rowe; Merci Kusel; Anthony Bosco; Kathy McKenna; Nicholas de Klerk; Peter David Sly; Patrick G Holt
Interleukin-10/interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history.
American journal of respiratory and critical care medicine 2009;179(3):205-11.
2009: Patrick G Holt
Prophylactic allergen vaccination: current and future perspectives.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen 2009;96():281-7; discussion 288.
2009: Patrick G Holt; Deborah H Strickland; Anthony Bosco; Frode L Jahnsen
Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm.
Advances in immunology 2009;104():51-113.
2009: Angela Rate; John W Upham; Anthony Bosco; Kathy L McKenna; Patrick G Holt
Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):72-83.
2009: Stephanie T Yerkovich; Marjut Roponen; Miranda E Smith; Kathy McKenna; Anthony Bosco; Lily S Subrata; Emilie Mamessier; Matthew E Wikström; Peter Le Souef; Peter David Sly; Patrick G Holt; John W Upham
Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response.
The Journal of allergy and clinical immunology 2009;123(1):209-216.e4.
2008: Patrick G Holt
Primary prevention by early intervention with specific immunotherapy.
Drugs of today (Barcelona, Spain : 1998) 2008;44 Suppl B():75-7.
2008: Merci Kusel; Nicholas de Klerk; Patrick G Holt; Peter David Sly
Antibiotic use in the first year of life and risk of atopic disease in early childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(12):1921-8.
2008: Patrick G Holt
Prenatal versus postnatal priming of allergen specific immunologic memory: the debate continues.
The Journal of allergy and clinical immunology 2008;122(4):717-8.
2008: Peter David Sly; Attilio L Boner; Bengt Björksten; Andy Bush; Adnan Custovic; Philippe A Eigenmann; James E Gern; Jorrit Gerritsen; Eckard Hamelmann; Peter J Helms; Robert F Lemanske; Fernando D Martinez; Soren Pedersen; Harald Renz; Hugh A Sampson; Erika von Mutius; Ulrich Wahn; Patrick G Holt
Early identification of atopy in the prediction of persistent asthma in children.
Lancet 2008;372(9643):1100-6.
2008: Graeme R Zosky; Alexander N Larcombe; O J White; J T Burchell; T Z Janosi; Zoltán Hantos; Patrick G Holt; Peter David Sly; Debra J Turner
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(5):829-38.
2008: Belinda J Hales; L J Pearce; Merci Kusel; Patrick G Holt; Peter David Sly; Wayne R Thomas
Differences in the antibody response to a mucosal bacterial antigen between allergic and non-allergic subjects.
Thorax 2008;63(3):221-7.
2008: Patrick G Holt; Deborah H Strickland; Matthew E Wikström; Frode L Jahnsen
Regulation of immunological homeostasis in the respiratory tract.
Nature reviews. Immunology 2008;8(2):142-52.
2008: Deborah H Strickland; Matthew E Wikstrom; Debra J Turner; Patrick G Holt
Mucosal regulatory T cells in airway hyperresponsiveness.
Chemical immunology and allergy 2008;94():40-7.
2007: Patrick G Holt; Peter David Sly
Prevention of allergic respiratory disease in infants: current aspects and future perspectives.
Current opinion in allergy and clinical immunology 2007;7(6):547-55.
2007: Christophe von Garnier; Matthew E Wikstrom; Graeme R Zosky; Debra J Turner; Peter David Sly; Miranda Smith; Jennifer A Thomas; Samantha R Judd; Deborah H Strickland; Patrick G Holt; Philip A Stumbles
Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):5748-59.
2007: Stephanie T Yerkovich; Matthew E Wikström; Devinda Suriyaarachchi; Susan L Prescott; John W Upham; Patrick G Holt
Postnatal development of monocyte cytokine responses to bacterial lipopolysaccharide.
Pediatric research 2007;62(5):547-52.
2007: Patrick G Holt; Peter David Sly
Th2 cytokines in the asthma late-phase response.
Lancet 2007;370(9596):1396-8.
2007: Meri K Tulic; Robert J Hurrelbrink; Cecilia M Prêle; Ingrid A Laing; John W Upham; Peter Le Souef; Peter David Sly; Patrick G Holt
TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):132-40.
2007: Julie Rowe; Merci Kusel; Barbara J Holt; Devinda Suriyaarachchi; Michael Serralha; Elysia M Hollams; Stephanie T Yerkovich; Lily S Subrata; Claire Ladyman; Agata Sadowska; Jamie Gillett; Elizabeth Fisher; Richard Loh; Lars Söderström; Staffan Ahlstedt; Peter David Sly; Patrick G Holt
Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort.
The Journal of allergy and clinical immunology 2007;119(5):1164-73.
2007: Merci Kusel; Nicholas H de Klerk; Tatiana Kebadze; Vaike Vohma; Patrick G Holt; Sebastian L Johnston; Peter David Sly
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma.
The Journal of allergy and clinical immunology 2007;119(5):1105-10.
2007: T A Douglas; Merci Kusel; E M Pascoe; Richard Loh; Patrick G Holt; Peter David Sly
Predictors of response to bronchial allergen challenge in 5- to 6-year-old atopic children.
Allergy 2007;62(4):401-7.
2007: Peter David Sly; Marie Deverell; Merci Kusel; Patrick G Holt
Exposure to environmental tobacco smoke in cars increases the risk of persistent wheeze in adolescents.
The Medical journal of Australia 2007;186(6):322.
2007: Stephen W Turner; Tricia Heaton; Julie Rowe; Devinda Suriyaarachchi; Michael Serralha; Barbara J Holt; Peter Franklin; Stephen M Stick; Jack Goldblatt; Peter David Sly; Peter N Le Souëf; Patrick G Holt
Early-onset atopy is associated with enhanced lymphocyte cytokine responses in 11-year-old children.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(3):371-80.
2007: Merci Kusel; Nicholas de Klerk; Patrick G Holt; Louis I Landau; Peter David Sly
Occurrence and management of acute respiratory illnesses in early childhood.
Journal of paediatrics and child health 2007;43(3):139-46.
2007: Stephanie T Yerkovich; Julie Rowe; Peter Richmond; Devinda Suriyaarachchi; Tricia Heaton; Elysia M Hollams; Claire Ladyman; Michael Serralha; Agata Sadowska; Richard Loh; Steven L Wesselingh; Peter David Sly; Patrick G Holt
Assessment of the potency and potential immunomodulatory effects of the measles mumps rubella and varicella vaccine in infants.
Vaccine 2007;25(10):1764-70.
2006: Gregory P White; Elysia M Hollams; Stephanie T Yerkovich; Anthony Bosco; Barbara J Holt; Mohammad Reza Bassami; Merci Kusel; Peter David Sly; Patrick G Holt
CpG methylation patterns in the IFNgamma promoter in naive T cells: variations during Th1 and Th2 differentiation and between atopics and non-atopics.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2006;17(8):557-64.
2006: Deborah H Strickland; Philip A Stumbles; Graeme R Zosky; Lily S Subrata; Jennifer A Thomas; Debra J Turner; Peter David Sly; Patrick G Holt
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells.
The Journal of experimental medicine 2006;203(12):2649-60.
2006: Frode L Jahnsen; Deborah H Strickland; Jennifer A Thomas; Iriani T Tobagus; Sylvia Napoli; Graeme R Zosky; Debra J Turner; Peter David Sly; Philip A Stumbles; Patrick G Holt
Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5861-7.
2006: Merci Kusel; Nicholas H de Klerk; Patrick G Holt; Tatiana Kebadze; Sebastian L Johnston; Peter David Sly
Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study.
The Pediatric infectious disease journal 2006;25(8):680-6.
2006: Matthew E Wikstrom; Eva Batanero; Miranda Smith; Jennifer A Thomas; Christophe von Garnier; Patrick G Holt; Philip A Stumbles
Influence of mucosal adjuvants on antigen passage and CD4+ T cell activation during the primary response to airborne allergen.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):913-24.
2006: Malin F Böttcher; Maria C Jenmalm; T Voor; Kaja Julge; Patrick G Holt; Bengt Björkstén
Cytokine responses to allergens during the first 2 years of life in Estonian and Swedish children.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(5):619-28.
2006: Anthony Bosco; Kathy L McKenna; Catherine J Devitt; Martin J Firth; Peter David Sly; Patrick G Holt
Identification of novel Th2-associated genes in T memory responses to allergens.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4766-77.
2006: Mark Kendall; Thomas J Mitchell; George Costigan; Mark Armitage; Jason C Lenzo; Jennifer A Thomas; Christophe von Garnier; Graeme R Zosky; Debra J Turner; Philip A Stumbles; Peter David Sly; Patrick G Holt; Wayne R Thomas
Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery.
The Journal of allergy and clinical immunology 2006;117(2):275-82.
2006: John W Upham; Angela Rate; Julie Rowe; Merci Kusel; Peter David Sly; Patrick G Holt
Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory.
Infection and immunity 2006;74(2):1106-12.
2006: Wendy H Oddy; Sebely Pal; Merci Kusel; Donna Vine; Nicholas H de Klerk; Peter Hartmann; Patrick G Holt; Peter David Sly; Paul R Burton; Fiona J Stanley; Louis I Landau
Atopy, eczema and breast milk fatty acids in a high-risk cohort of children followed from birth to 5 yr.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2006;17(1):4-10.
2005: Julie Rowe; Stephanie T Yerkovich; Peter Richmond; Devinda Suriyaarachchi; Elizabeth Fisher; Leonie Feddema; Richard Loh; Peter David Sly; Patrick G Holt
Th2-associated local reactions to the acellular diphtheria-tetanus-pertussis vaccine in 4- to 6-year-old children.
Infection and immunity 2005;73(12):8130-5.
2005: Merci Kusel; Patrick G Holt; Nicholas de Klerk; Peter David Sly
Support for 2 variants of eczema.
The Journal of allergy and clinical immunology 2005;116(5):1067-72.
2005: Patrick G Holt; W R Thomas
Sensitization to airborne environmental allergens: unresolved issues.
Nature immunology 2005;6(10):957-60.
2005: Christophe von Garnier; Luis Filgueira; Matthew E Wikstrom; Miranda Smith; Jennifer A Thomas; Deborah H Strickland; Patrick G Holt; Philip A Stumbles
Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1609-18.
2005: Patrick G Holt; John W Upham; Peter David Sly
Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies.
The Journal of allergy and clinical immunology 2005;116(1):16-24; quiz 25.
2005: John W Upham; Patrick G Holt
Environment and development of atopy.
Current opinion in allergy and clinical immunology 2005;5(2):167-72.
2005: Judah A Denburg; Holly M Hatfield; Michael M Cyr; Lisa M Hayes; Patrick G Holt; Roma Sehmi; Janet A Dunstan; Susan L Prescott
Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy.
Pediatric research 2005;57(2):276-81.
2005: Tricia Heaton; Julie Rowe; S Turner; R C Aalberse; Nicholas de Klerk; Devinda Suriyaarachchi; Michael Serralha; Barbara J Holt; Elysia M Hollams; Stephanie T Yerkovich; K Holt; Peter David Sly; Jack Goldblatt; Peter Le Souef; Patrick G Holt
An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children.
Lancet 2005;365(9454):142-9.
2005: Patrick G Holt
Pulmonary dendritic cells in local immunity to inert and pathogenic antigens in the respiratory tract.
Proceedings of the American Thoracic Society 2005;2(2):116-20.
2004: H S Lehmann; Tricia Heaton; Dominic F J Mallon; Patrick G Holt
Staphylococcal enterotoxin-B-mediated stimulation of interleukin-13 production as a potential aetiologic factor in eczema in infants.
International archives of allergy and immunology 2004;135(4):306-12.
2004: John W Upham; Patrick G Holt; Angie Taylor; Catherine A Thornton; Susan L Prescott
HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses.
The Journal of allergy and clinical immunology 2004;114(5):1202-8.
2004: Jacqui Joseph-Bowen; Nicholas de Klerk; Patrick G Holt; Peter David Sly
Relationship of asthma, atopy, and bronchial responsiveness to serum eosinophil cationic proteins in early childhood.
The Journal of allergy and clinical immunology 2004;114(5):1040-5.
2004: Belinda J Hales; Anthony Bosco; Kristina L Mills; Lee A Hazell; Richard Loh; Patrick G Holt; Wayne R Thomas
Isoforms of the major peanut allergen Ara h 2: IgE binding in children with peanut allergy.
International archives of allergy and immunology 2004;135(2):101-7.
2004: Julie Rowe; JT Poolman; C Macaubas; Peter David Sly; Richard Loh; Patrick G Holt
Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody.
Vaccine 2004;22(29-30):3986-92.
2004: Catherine A Thornton; John W Upham; Matthew E Wikström; Barbara J Holt; Gregory P White; Mary J Sharp; Peter David Sly; Patrick G Holt
Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3084-92.
2004: Patrick G Holt; Peter David Sly; Fernando D Martinez; Scott Weiss; Bengt Björkstén; Erika von Mutius; Ulrich Wahn
Drug development strategies for asthma: in search of a new paradigm.
Nature immunology 2004;5(7):695-8.
2004: Julie Rowe; Tricia Heaton; Merci Kusel; Devinda Suriyaarachchi; Michael Serralha; Barbara J Holt; Nicholas de Klerk; Peter David Sly; Patrick G Holt
High IFN-gamma production by CD8+ T cells and early sensitization among infants at high risk of atopy.
The Journal of allergy and clinical immunology 2004;113(4):710-6.
2004: Jacqui Joseph-Bowen; Nicholas H de Klerk; Martin J Firth; Garth E Kendall; Patrick G Holt; Peter David Sly
Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children.
American journal of respiratory and critical care medicine 2004;169(7):850-4.
2004: Janet A Dunstan; Trevor A Mori; Anne Barden; Lawrence J Beilin; Patrick G Holt; Philip Calder; Angie L Taylor; Susan L Prescott
Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition.
European journal of clinical nutrition 2004;58(3):429-37.
2004: Iriani T Tobagus; Wayne R Thomas; Patrick G Holt
Adjuvant costimulation during secondary antigen challenge directs qualitative aspects of oral tolerance induction, particularly during the neonatal period.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2274-85.
2004: Patrick G Holt; John W Upham
The role of dendritic cells in asthma.
Current opinion in allergy and clinical immunology 2004;4(1):39-44.
2004: Graeme R Zosky; Christophe von Garnier; Philip A Stumbles; Patrick G Holt; Peter David Sly; Debra J Turner
The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose.
Respiratory research 2004;5():15.
2004: Patrick G Holt
The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life.
Paediatric respiratory reviews 2004;5 Suppl A():S27-30.
2003: Janet A Dunstan; Trevor A Mori; Anne Barden; Lawrence J Beilin; Angie L Taylor; Patrick G Holt; Susan L Prescott
Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial.
The Journal of allergy and clinical immunology 2003;112(6):1178-84.
2003: Susan L Prescott; B King; T L Strong; Patrick G Holt
The value of perinatal immune responses in predicting allergic disease at 6 years of age.
Allergy 2003;58(11):1187-94.
2003: C Macaubas; Nicholas H de Klerk; Barbara J Holt; C Wee; Garth E Kendall; Martin J Firth; Peter David Sly; Patrick G Holt
Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.
Lancet 2003;362(9391):1192-7.
2003: Paul S Noakes; Patrick G Holt; Susan L Prescott
Maternal smoking in pregnancy alters neonatal cytokine responses.
Allergy 2003;58(10):1053-8.
2003: Patrick G Holt; Julie Rowe; Richard Loh; Peter David Sly
Developmental factors associated with risk for atopic disease: implications for vaccine strategies in early childhood.
Vaccine 2003;21(24):3432-5.
2003: Joong C Huh; Deborah H Strickland; Frode L Jahnsen; Debra J Turner; Jennifer A Thomas; Sylvia Napoli; Iriani T Tobagus; Philip A Stumbles; Peter David Sly; Patrick G Holt
Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma.
The Journal of experimental medicine 2003;198(1):19-30.
2003: Philip A Stumbles; John W Upham; Patrick G Holt
Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2003;111(7-8):741-55.
2003: Patrick G Holt
Functionally mature virus-specific CD8(+) T memory cells in congenitally infected newborns: proof of principle for neonatal vaccination?
The Journal of clinical investigation 2003;111(11):1645-7.
2003: Stephen M Stick; Patrick G Holt
The airway epithelium as immune modulator: the LARC ascending.
American journal of respiratory cell and molecular biology 2003;28(6):641-4.
2003: Susan L Prescott; Angie Taylor; B King; Janet A Dunstan; John W Upham; Catherine A Thornton; Patrick G Holt
Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(5):566-72.
2003: Janet A Dunstan; Trevor A Mori; Anne Barden; Lawrence J Beilin; Angie L Taylor; Patrick G Holt; Susan L Prescott
Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(4):442-8.
2003: M J Sharp; Julie Rowe; Merci Kusel; Peter David Sly; Patrick G Holt
Specific patterns of responsiveness to microbial antigens staphylococcal enterotoxin B and purified protein derivative by cord blood mononuclear cells are predictive of risk for development of atopic dermatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(4):435-41.
2003: Wendy H Oddy; Peter David Sly; Nicholas H de Klerk; Louis I Landau; Garth E Kendall; Patrick G Holt; Fiona J Stanley
Breast feeding and respiratory morbidity in infancy: a birth cohort study.
Archives of disease in childhood 2003;88(3):224-8.
2002: John W Upham; Peter T Lee; Barbara J Holt; Tricia Heaton; Susan L Prescott; Mary J Sharp; Peter David Sly; Patrick G Holt
Development of interleukin-12-producing capacity throughout childhood.
Infection and immunity 2002;70(12):6583-8.
2002: Patrick G Holt; Peter David Sly
Interactions between RSV infection, asthma, and atopy: unraveling the complexities.
The Journal of experimental medicine 2002;196(10):1271-5.
2002: Meri K Tulic; Patrick G Holt; Peter David Sly
Modification of acute and late-phase allergic responses to ovalbumin with lipopolysaccharide.
International archives of allergy and immunology 2002;129(2):119-28.
2002: Peter David Sly; Patrick G Holt
Breast is best for preventing asthma and allergies--or is it?
Lancet 2002;360(9337):887-8.
2002: Grant Morahan; Dexing Huang; Mark Wu; Barbara J Holt; Gregory P White; Garth E Kendall; Peter David Sly; Patrick G Holt
Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children.
Lancet 2002;360(9331):455-9.
2002: Peter Jecker; Wolf J Mann; Andrew S McWilliam; Patrick G Holt
Dendritic cell influx differs between the subglottic and glottic mucosae during acute laryngotracheitis induced by a broad spectrum of stimuli.
The Annals of otology, rhinology, and laryngology 2002;111(7 Pt 1):567-72.
2002: Wendy H Oddy; Nicholas H de Klerk; Peter David Sly; Patrick G Holt
The effects of respiratory infections, atopy, and breastfeeding on childhood asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(5):899-905.
2002: Gregory P White; Paul M Watt; Barbara J Holt; Patrick G Holt
Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2820-7.
2002: Patrick G Holt; Peter David Sly
Interactions between respiratory tract infections and atopy in the aetiology of asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2002;19(3):538-45.
2002: Theodore W K Ng; Patrick G Holt; Susan L Prescott
Cellular immune responses to ovalbumin and house dust mite in egg-allergic children.
Allergy 2002;57(3):207-14.
2002: Patrick G Holt
The role of airway dendritic cell populations in regulation of T-cell responses to inhaled antigens: atopic asthma as a paradigm.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):161-8.
2002: C Macaubas; Peter T Lee; TB Smallacombe; Barbara J Holt; C Wee; Peter David Sly; Patrick G Holt
Reciprocal patterns of allergen-induced GATA-3 expression in peripheral blood mononuclear cells from atopics vs. non-atopics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(1):97-106.
2001: A Rudin; C Macaubas; C Wee; Barbara J Holt; P D Slya; Patrick G Holt
"Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children.
Allergy 2001;56(11):1042-8.
2001: Frode L Jahnsen; Edward Moloney; T Hogan; John W Upham; Conor M Burke; Patrick G Holt
Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge.
Thorax 2001;56(11):823-6.
2001: Peter Jecker; Andrew S McWilliam; A Marsh; Patrick G Holt; Wolf J Mann; R Pabst; J Westermann
Acute laryngotracheitis in the rat induced by Sendai virus: the influx of six different types of immunocompetent cells into the laryngeal mucosa differs strongly between the subglottic and the glottic compartment.
The Laryngoscope 2001;111(9):1645-51.
2001: Peter T Lee; Patrick G Holt; Andrew S McWilliam
Failure of MHC class II expression in neonatal alveolar macrophages: potential role of class II transactivator.
European journal of immunology 2001;31(8):2347-56.
2001: Peter T Lee; Patrick G Holt; Andrew S McWilliam
Ontogeny of rat pulmonary alveolar macrophage function: evidence for a selective deficiency in il-10 and nitric oxide production by newborn alveolar macrophages.
Cytokine 2001;15(1):53-7.
2001: Philip A Stumbles; Deborah H Strickland; C L Pimm; S F Proksch; A M Marsh; Andrew S McWilliam; Anthony Bosco; Iriani T Tobagus; Jennifer A Thomas; Sylvia Napoli; A E Proudfoot; Timothy Wells; Patrick G Holt
Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulus.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):228-34.
2001: Julie Rowe; C Macaubas; T Monger; Barbara J Holt; J Harvey; JT Poolman; Richard Loh; Peter David Sly; Patrick G Holt
Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic th1 function.
The Journal of infectious diseases 2001;184(1):80-8.
2001: L M Bowman; Patrick G Holt
Selective enhancement of systemic Th1 immunity in immunologically immature rats with an orally administered bacterial extract.
Infection and immunity 2001;69(6):3719-27.
2001: Philip A Stumbles; J Thomas; Patrick G Holt
Identification and isolation of rodent lung dendritic cells.
Methods in molecular medicine 2001;64():73-83.
2001: C Macaubas; Patrick G Holt
Regulation of cytokine production in T-cell responses to inhalant allergen:GATA-3 expression distinguishes between Th1- and Th2-polarized immunity.
International archives of allergy and immunology 2001;124(1-3):176-9.
2000: Patrick G Holt
Parasites, atopy, and the hygiene hypothesis: resolution of a paradox?
Lancet 2000;356(9243):1699-701.
2000: Peter T Lee; Patrick G Holt; Andrew S McWilliam
Role of alveolar macrophages in innate immunity in neonates: evidence for selective lipopolysaccharide binding protein production by rat neonatal alveolar macrophages.
American journal of respiratory cell and molecular biology 2000;23(5):652-61.
2000: Patrick G Holt
Antigen presentation in the lung.
American journal of respiratory and critical care medicine 2000;162(4 Pt 2):S151-6.
2000: Patrick G Holt; C Macaubas; Susan L Prescott; Peter David Sly
Primary sensitization to inhalant allergens.
American journal of respiratory and critical care medicine 2000;162(3 Pt 2):S91-4.
2000: Maria C Jenmalm; Helena Aniansson Zdolsek; Patrick G Holt; Bengt Björkstén
Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2000;11(3):175-82.
2000: Patrick G Holt; C A Jones
The development of the immune system during pregnancy and early life.
Allergy 2000;55(8):688-97.
2000: Patrick G Holt; Peter David Sly
Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs.
Thorax 2000;55(8):700-3.
2000: Julie Rowe; C Macaubas; T M Monger; Barbara J Holt; J Harvey; JT Poolman; Peter David Sly; Patrick G Holt
Antigen-specific responses to diphtheria-tetanus-acellular pertussis vaccine in human infants are initially Th2 polarized.
Infection and immunity 2000;68(7):3873-7.
2000: Patrick G Holt; A Rudin; C Macaubas; Barbara J Holt; Julie Rowe; Richard Loh; Peter David Sly
Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.
The Journal of allergy and clinical immunology 2000;105(6 Pt 1):1117-22.
2000: M K Tulić; JL Wale; Patrick G Holt; Peter David Sly
Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(5):870-7.
2000: Susan L Prescott; Patrick G Holt; M Jenmalm; Bengt Björkstén
Effects of maternal allergen-specific IgG in cord blood on early postnatal development of allergen-specific T-cell immunity.
Allergy 2000;55(5):470-5.
2000: M K Tulić; JL Wale; Patrick G Holt; Peter David Sly
Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide.
American journal of respiratory cell and molecular biology 2000;22(5):604-12.
2000: Patrick G Holt; Philip A Stumbles
Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: the respiratory tract as a paradigm.
The Journal of allergy and clinical immunology 2000;105(3):421-9.
2000: Patrick G Holt
Key factors in the development of asthma: atopy.
American journal of respiratory and critical care medicine 2000;161(3 Pt 2):S172-5.
2000: Patrick G Holt; Philip A Stumbles
Characterization of dendritic cell populations in the respiratory tract.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2000;13(4):361-7.
2000: C Macaubas; Susan L Prescott; TJ Venaille; Barbara J Holt; TB Smallacombe; Peter David Sly; Patrick G Holt
Primary sensitization to inhalant allergens.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2000;11 Suppl 13():9-11.
1999: Peter Jecker; Andrew S McWilliam; S Napoli; Patrick G Holt; R Pabst; Martin Westhofen; J Westermann
Acute laryngitis in the rat induced by Moraxella catarrhalis and Bordetella pertussis: number of neutrophils, dendritic cells, and T and B lymphocytes accumulating during infection in the laryngeal mucosa strongly differs in adjacent locations.
Pediatric research 1999;46(6):760-6.
1999: Patrick G Holt; C Macaubas; Philip A Stumbles; Peter David Sly
The role of allergy in the development of asthma.
Nature 1999;402(6760 Suppl):B12-7.
1999: Wendy H Oddy; Patrick G Holt; Peter David Sly; Anne W Read; Louis I Landau; Fiona J Stanley; Garth E Kendall; Paul R Burton
Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study.
BMJ (Clinical research ed.) 1999;319(7213):815-9.
1999: C Macaubas; Peter David Sly; P Burton; K Tiller; A Yabuhara; Barbara J Holt; TB Smallacombe; Garth E Kendall; Maria C Jenmalm; Patrick G Holt
Regulation of T-helper cell responses to inhalant allergen during early childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(9):1223-31.
1999: Maria C Jenmalm; Bengt Björkstén; C Macaubas; Barbara J Holt; TB Smallacombe; Patrick G Holt
Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1999;10(3):168-77.
1999: Patrick G Holt; Philip A Stumbles; Andrew S McWilliam
Functional studies on dendritic cells in the respiratory tract and related mucosal tissues.
Journal of leukocyte biology 1999;66(2):272-5.
1999: Eiko Koike; Takahiro Kobayashi; M Murakami; AS McWilliam; Patrick G Holt
Mechanisms of ozone-induced inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage-mediated immunosuppressive activity in rats.
Journal of leukocyte biology 1999;66(1):75-82.
1999: Patrick G Holt
Potential role of environmental factors in the etiology and pathogenesis of atopy: a working model.
Environmental health perspectives 1999;107 Suppl 3():485-7.
1999: Helena Aniansson Zdolsek; Jan Ernerudh; Patrick G Holt; J Nilsson; Bengt Björkstén
Expression of the T-cell markers CD3, CD4 and CD8 in healthy and atopic children during the first 18 months of life.
International archives of allergy and immunology 1999;119(1):6-12.
1999: Susan L Prescott; C Macaubas; TB Smallacombe; Barbara J Holt; Peter David Sly; Patrick G Holt
Development of allergen-specific T-cell memory in atopic and normal children.
Lancet 1999;353(9148):196-200.
1999: Patrick G Holt; C Macaubas; Susan L Prescott; Peter David Sly
Microbial stimulation as an aetiologic factor in atopic disease.
Allergy 1999;54 Suppl 49():12-6.
1998: AS McWilliam; Patrick G Holt
Immunobiology of dendritic cells in the respiratory tract: steady-state and inflammatory sentinels?
Toxicology letters 1998;102-103():323-9.
1998: Philip A Stumbles; Jennifer A Thomas; C L Pimm; Peter T Lee; TJ Venaille; S Proksch; Patrick G Holt
Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity.
The Journal of experimental medicine 1998;188(11):2019-31.
1998: Susan L Prescott; C Macaubas; TB Smallacombe; Barbara J Holt; Peter David Sly; Richard Loh; Patrick G Holt
Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 5():39-44; discussion 50-1.
1998: R M Bingisser; Peta A Tilbrook; Patrick G Holt; Ursula R Kees
Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5729-34.
1998: Patrick G Holt
Programming for responsiveness to environmental antigens that trigger allergic respiratory disease in adulthood is initiated during the perinatal period.
Environmental health perspectives 1998;106 Suppl 3():795-800.
1998: Susan L Prescott; C Macaubas; Barbara J Holt; TB Smallacombe; Richard Loh; Peter David Sly; Patrick G Holt
Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4730-7.
1998: Patrick G Holt
Regulation of immune responses at mucosal surfaces: allergic respiratory disease as a paradigm.
Immunology and cell biology 1998;76(2):119-24.
1998: Eiko Koike; Takahiro Kobayashi; D J Nelson; AS McWilliam; Patrick G Holt
Effect of ozone exposure on alveolar macrophage-mediated immunosuppressive activity in rats.
Toxicological sciences : an official journal of the Society of Toxicology 1998;41(2):217-23.
1998: Patrick G Holt
Mucosal immunity in relation to the development of oral tolerance/sensitization.
Allergy 1998;53(46 Suppl):16-9.
1998: Patrick G Holt; C Macaubas; Peter David Sly
Strategic targets for primary prevention of allergic disease in childhood.
Allergy 1998;53(45 Suppl):72-6.
1997: Patrick G Holt; C Macaubas
Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period.
Current opinion in immunology 1997;9(6):782-7.
1997: A Yabuhara; C Macaubas; Susan L Prescott; TJ Venaille; Barbara J Holt; W Habre; Peter David Sly; Patrick G Holt
TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(11):1261-9.
1997: Maria C Jenmalm; Patrick G Holt; Bengt Björkstén
Maternal influence on IgG subclass antibodies to Bet v 1 during the first 18 months of life as detected with a sensitive ELISA.
International archives of allergy and immunology 1997;114(2):175-84.
1997: Patrick G Holt; Peter David Sly; B Björkstén
Atopic versus infectious diseases in childhood: a question of balance?
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1997;8(2):53-8.
1997: Patrick G Holt; J A Thomas
Steroids inhibit uptake and/or processing but not presentation of antigen by airway dendritic cells.
Immunology 1997;91(1):145-50.
1997: Susan L Prescott; C Macaubes; A Yabuhara; TJ Venaille; Barbara J Holt; W Habre; Richard Loh; Peter David Sly; Patrick G Holt
Developing patterns of T cell memory to environmental allergens in the first two years of life.
International archives of allergy and immunology 1997;113(1-3):75-9.
1997: Patrick G Holt; C Macaubas; D Cooper; D J Nelson; AS McWilliam
Th-1/Th-2 switch regulation in immune responses to inhaled antigens. Role of dendritic cells in the aetiology of allergic respiratory disease.
Advances in experimental medicine and biology 1997;417():301-6.
1997: Patrick G Holt; A Yabuhara; S Prescott; TJ Venaille; C Macaubas; Barbara J Holt; Bengt Björkstén; Peter David Sly
Allergen recognition in the origin of asthma.
Ciba Foundation symposium 1997;206():35-49; discussion 49-55, 106-10.
1997: Andrew S McWilliam; A M Marsh; Patrick G Holt
Inflammatory infiltration of the upper airway epithelium during Sendai virus infection: involvement of epithelial dendritic cells.
Journal of virology 1997;71(1):226-36.
1996: A S McWilliam; S Napoli; A M Marsh; F L Pemper; D J Nelson; C L Pimm; Philip A Stumbles; Timothy Wells; Patrick G Holt
Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli.
The Journal of experimental medicine 1996;184(6):2429-32.
1996: R J Steptoe; Patrick G Holt; Paul G McMenamin
Origin and steady-state turnover of major histocompatibility complex class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye.
Journal of neuroimmunology 1996;68(1-2):67-76.
1996: Patrick G Holt
Infections and the development of allergy.
Toxicology letters 1996;86(2-3):205-10.
1996: Bengt Björkstén; Barbara J Holt; M J Baron-Hay; A K M Munir; Patrick G Holt
Low-level exposure to house dust mites stimulates T-cell responses during early childhood independent of atopy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(7):775-9.
1996: Patrick G Holt
Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood.
The Journal of experimental medicine 1996;183(4):1297-301.
1996: D Strickland; U R Kees; Patrick G Holt
Regulation of T-cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction.
Immunology 1996;87(2):250-8.
1996: D Strickland; U R Kees; Patrick G Holt
Regulation of T-cell activation in the lung: isolated lung T cells exhibit surface phenotypic characteristics of recent activation including down-modulated T-cell receptors, but are locked into the G0/G1 phase of the cell cycle.
Immunology 1996;87(2):242-9.
1995: A S McWilliam; D J Nelson; Patrick G Holt
The biology of airway dendritic cells.
Immunology and cell biology 1995;73(5):405-13.
1995: D J Nelson; Patrick G Holt
Defective regional immunity in the respiratory tract of neonates is attributable to hyporesponsiveness of local dendritic cells to activation signals.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3517-24.
1995: N Bilyk; Patrick G Holt
Cytokine modulation of the immunosuppressive phenotype of pulmonary alveolar macrophage populations.
Immunology 1995;86(2):231-7.
1995: R J Steptoe; Patrick G Holt; Paul G McMenamin
Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris.
Immunology 1995;85(4):630-7.
1995: C McMenamin; M McKersey; P Kühnlein; Thomas Hünig; Patrick G Holt
Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4390-4.
1995: Patrick G Holt; P O'Keeffe; Barbara J Holt; J W Upham; M J Baron-Hay; Cenk Suphioglu; B Knox; G A Stewart; Wayne R Thomas; Peter David Sly
T-cell "priming" against environmental allergens in human neonates: sequential deletion of food antigen reactivity during infancy with concomitant expansion of responses to ubiquitous inhalant allergens.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1995;6(2):85-90.
1995: Patrick G Holt; C Somerville; M J Baron-Hay; Barbara J Holt; P D Sly
Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T-cells from infants at low versus high genetic risk for atopy.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1995;6(2):80-4.
1995: Patrick G Holt
Postnatal maturation of immune competence during infancy and childhood.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1995;6(2):59-70.
1995: D J Nelson; A S McWilliam; S Haining; Patrick G Holt
Modulation of airway intraepithelial dendritic cells following exposure to steroids.
American journal of respiratory and critical care medicine 1995;151(2 Pt 1):475-81.
1995: Patrick G Holt
Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 1995;6(1):1-10.
1995: Patrick G Holt; D J Nelson; A S McWilliam
Population dynamics and functions of respiratory tract dendritic cells in the rat.
Advances in experimental medicine and biology 1995;378():177-81.
1995: Patrick G Holt
Immune tolerance and protection against allergic sensitization.
Allergy 1995;50(25 Suppl):34-6.
1995: J W Upham; D H Strickland; N Bilyk; Bruce W S Robinson; Patrick G Holt
Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion.
Immunology 1995;84(1):142-7.
1994: Patrick G Holt
Immunoprophylaxis of atopy: light at the end of the tunnel?
Immunology today 1994;15(10):484-9.
1994: C McMenamin; C Pimm; M McKersey; Patrick G Holt
Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells.
Science (New York, N.Y.) 1994;265(5180):1869-71.
1994: Patrick G Holt
A potential vaccine strategy for asthma and allied atopic diseases during early childhood.
Lancet 1994;344(8920):456-8.
1994: Patrick G Holt; S Haining; D J Nelson; J D Sedgwick
Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(1):256-61.
1994: Paul G McMenamin; J Crewe; S Morrison; Patrick G Holt
Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye.
Investigative ophthalmology & visual science 1994;35(8):3234-50.
1994: J W Upham; C McMenamin; M A Schon-Hegrad; Bruce W S Robinson; Patrick G Holt
Functional analysis of human bronchial mucosal T cells extracted with interleukin-2.
American journal of respiratory and critical care medicine 1994;149(6):1608-13.
1994: A S McWilliam; D Nelson; J A Thomas; Patrick G Holt
Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.
The Journal of experimental medicine 1994;179(4):1331-6.
1994: D J Nelson; C McMenamin; A S McWilliam; M Brenan; Patrick G Holt
Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.
The Journal of experimental medicine 1994;179(1):203-12.
1993: D H Strickland; T Thepen; U R Kees; G Kraal; Patrick G Holt
Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages.
Immunology 1993;80(2):266-72.
1993: C McMenamin; Patrick G Holt
The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production.
The Journal of experimental medicine 1993;178(3):889-99.
1993: N Bilyk; Patrick G Holt
Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1993;177(6):1773-7.
1993: C McMenamin; B Chilna; Patrick G Holt
Phenotypic and functional analysis of mucosal T cells isolated from tissue explants of rat upper respiratory tract.
Journal of immunological methods 1993;160(2):219-26.
1993: Patrick G Holt; J Oliver; N Bilyk; C McMenamin; Paul G McMenamin; Georg Kraal; T Thepen
Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.
The Journal of experimental medicine 1993;177(2):397-407.
1993: Patrick G Holt
Pulmonary dendritic cell populations.
Advances in experimental medicine and biology 1993;329():557-62.
1992: T Thepen; C McMenamin; B Girn; Georg Kraal; Patrick G Holt
Regulation of IgE production in pre-sensitized animals: in vivo elimination of alveolar macrophages preferentially increases IgE responses to inhaled allergen.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(12):1107-14.
1992: Patrick G Holt; J B Clough; Barbara J Holt; M J Baron-Hay; A H Rose; Bruce W S Robinson; Wayne R Thomas
Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(12):1093-9.
1992: C McMenamin; B Girn; Patrick G Holt
The distribution of IgE plasma cells in lymphoid and non-lymphoid tissues of high-IgE responder rats: differential localization of antigen-specific and 'bystander' components of the IgE response to inhaled antigen.
Immunology 1992;77(4):592-6.
1992: Paul G McMenamin; I Holthouse; Patrick G Holt
Class II major histocompatibility complex (Ia) antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia.
Immunology 1992;77(3):385-93.
1992: M J Garlepp; A H Rose; R V Bowman; N Mavaddat; J Dench; Barbara J Holt; M Baron-Hay; Patrick G Holt; Bruce W S Robinson
A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals.
Immunology 1992;77(1):31-7.
1992: Patrick G Holt; J Oliver; C McMenamin; M A Schon-Hegrad
Studies on the surface phenotype and functions of dendritic cells in parenchymal lung tissue of the rat.
Immunology 1992;75(4):582-7.
1991: N Bilyk; Patrick G Holt
The surface phenotypic characterization of lung macrophages in C3H/HeJ mice.
Immunology 1991;74(4):645-51.
1991: T Thepen; C McMenamin; J Oliver; Georg Kraal; Patrick G Holt
Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity.
European journal of immunology 1991;21(11):2845-50.
1991: C McMenamin; J Oliver; B Girn; Barbara J Holt; U R Kees; Wayne R Thomas; Patrick G Holt
Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Tcr alpha-/beta- lymphocytes (putative gamma/delta T cells).
Immunology 1991;74(2):234-9.
1991: M A Schon-Hegrad; J Oliver; Paul G McMenamin; Patrick G Holt
Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways.
The Journal of experimental medicine 1991;173(6):1345-56.
1991: Patrick G Holt; C McMenamin; M A Schon-Hegrad; D Strickland; D Nelson; L Wilkes; N Bilyk; J Oliver; Barbara J Holt; Paul G McMenamin
Immunoregulation of asthma: control of T-lymphocyte activation in the respiratory tract.
The European respiratory journal. Supplement 1991;13():6s-15s.
1991: C McMenamin; M Schon-Hegrad; J Oliver; B Girn; Patrick G Holt
Regulation of IgE responses to inhaled antigens: cellular mechanisms underlying allergic sensitization versus tolerance induction.
International archives of allergy and applied immunology 1991;94(1-4):78-82.
1991: Patrick G Holt; C McMenamin
IgE and mucosal immunity: studies on the role of intraepithelial Ia + dendritic cells and gamma/delta T-lymphocytes in regulation of T-cell activation in the lung.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1991;21 Suppl 1():148-52.
1990: D Nelson; D Strickland; Patrick G Holt
Selective attrition of non-recirculating T cells during normal passage through the lung vascular bed.
Immunology 1990;69(3):476-81.
1990: Patrick G Holt; M A Schon-Hegrad; J Oliver; Barbara J Holt; Paul G McMenamin
A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium.
International archives of allergy and applied immunology 1990;91(2):155-9.
1990: Patrick G Holt; M A Schon-Hegrad; Paul G McMenamin
Dendritic cells in the respiratory tract.
International reviews of immunology 1990;6(2-3):139-49.
1989: Patrick G Holt; M A Schon-Hegrad; M J Phillips; Paul G McMenamin
Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(6):597-601.
1989: Patrick G Holt; C McMenamin
Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(3):255-62.
1989: Patrick G Holt; N Bilyk; J Vines; K J Turner; Wayne R Thomas
In vivo arming of cutaneous mast cell receptors by IgE released from macrophages.
International archives of allergy and applied immunology 1989;89(4):381-6.
1988: N Bilyk; J S Mackenzie; J M Papadimitriou; Patrick G Holt
Functional studies on macrophage populations in the airways and the lung wall of SPF mice in the steady-state and during respiratory virus infection.
Immunology 1988;65(3):417-25.
1988: Patrick G Holt; Ursula R Kees; M A Shon-Hegrad; A Rose; J Ford; N Bilyk; R Bowman; Bruce W S Robinson
Limiting-dilution analysis of T cells extracted from solid human lung tissue: comparison of precursor frequencies for proliferative responses and lymphokine production between lung and blood T cells from individual donors.
Immunology 1988;64(4):649-54.
1988: Patrick G Holt; J Vines; D Britten
Sublingual allergen administration. I. Selective suppression of IgE production in rats by high allergen doses.
Clinical allergy 1988;18(3):229-34.
1988: Patrick G Holt; J Vines; D Britten
Suppression of IgE responses by antigen inhalation: failure of tolerance mechanism(s) in newborn rats.
Immunology 1988;63(4):591-3.
1988: Patrick G Holt; M A Schon-Hegrad; J Oliver
MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.
The Journal of experimental medicine 1988;167(2):262-74.
1988: Patrick G Holt; J Vines; N Bilyk
Effect of influenza virus infection on allergic sensitization to inhaled antigen in mice.
International archives of allergy and applied immunology 1988;86(1):121-3.
1988: K J Turner; A Marzo; Barbara J Holt; A Wharton; J M Papadimitriou; K J Cameron; N P Siemensma; Patrick G Holt
Ultrastructural localization of IgE in peripheral blood monocytes from atopics.
International archives of allergy and applied immunology 1988;85(1):109-12.
1987: Patrick G Holt; M A Schon-Hegrad
Localization of T cells, macrophages and dendritic cells in rat respiratory tract tissue: implications for immune function studies.
Immunology 1987;62(3):349-56.
1987: K J Turner; Patrick G Holt; Barbara J Holt; K J Cameron; J D Hobday; P Thompson; M Phillips
In vitro synthesis of IgE by human peripheral blood leucocytes: V. Functional heterogeneity within the IgE-B-cell pool.
Clinical and experimental immunology 1987;68(2):409-17.
1987: K J Turner; Barbara J Holt; K J Cameron; Patrick G Holt
Functional heterogeneity within the human peripheral blood B cell pool engaged in IgE synthesis.
International archives of allergy and applied immunology 1987;82(3-4):394-7.
1986: Patrick G Holt; Bruce W S Robinson; M Reid; U R Kees; A Warton; V H Dawson; A Rose; M Schon-Hegrad; J M Papadimitriou
Extraction of immune and inflammatory cells from human lung parenchyma: evaluation of an enzymatic digestion procedure.
Clinical and experimental immunology 1986;66(1):188-200.
1985: K J Turner; Patrick G Holt; J D Hobday; K J Cameron; Barbara J Holt
In vitro synthesis of IgE by human peripheral blood leucocytes. IV. Longitudinal study of regulatory T-cell activity in atopics.
International archives of allergy and applied immunology 1985;76(4):308-12.
1983: K J Turner; Patrick G Holt; Barbara J Holt; K J Cameron
In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.
Clinical and experimental immunology 1983;51(2):387-94.