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Bettina Holtmann

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Stefanie Saenger; Susanne Schroeder; Michael Sendtner; Will Spooren; Taleen Hanania; Andreas Hoeflich; Bettina Holtmann; Heidemarie Kletzl; Mark R Nilges; Susanne Ostrowitzki; Friedrich Metzger
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Christina Zuern; Michael Sendtner; Stephanie Starke; Christoph Wanner; Tobias Fischer; Jan Galle; Jutta Heimrich; Bettina Holtmann; Laszlo Krenacs; Alois Palmetshofer; Stefan Seibold
Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
Sibylle Jablonka; Bettina Holtmann; Michael Sendtner; Friedrich Metzger
Therapeutic effects of PEGylated insulin-like growth factor I in the pmn mouse model of motoneuron disease.

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2012: Stefanie Saenger; Susanne Schroeder; Michael Sendtner; Will Spooren; Taleen Hanania; Andreas Hoeflich; Bettina Holtmann; Heidemarie Kletzl; Mark R Nilges; Susanne Ostrowitzki; Friedrich Metzger
Functional improvement in mouse models of familial amyotrophic lateral sclerosis by PEGylated insulin-like growth factor I treatment depends on disease severity.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2012;13(5):418-29.
2012: Christina Zuern; Michael Sendtner; Stephanie Starke; Christoph Wanner; Tobias Fischer; Jan Galle; Jutta Heimrich; Bettina Holtmann; Laszlo Krenacs; Alois Palmetshofer; Stefan Seibold
Microtubule associated tumor suppressor 1 deficient mice develop spontaneous heart hypertrophy and SLE-like lymphoproliferative disease.
International journal of oncology 2012;40(4):1079-88.
2011: Sibylle Jablonka; Bettina Holtmann; Michael Sendtner; Friedrich Metzger
Therapeutic effects of PEGylated insulin-like growth factor I in the pmn mouse model of motoneuron disease.
Experimental neurology 2011;232(2):261-9.
2009: Matthias Fischer; Patricia Marques Pereira; Bettina Holtmann; Christian M Simon; Andre Hanauer; Martin Heisenberg; Michael Sendtner
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Molecular and cellular neurosciences 2009;42(2):134-41.
2008: Lise Gutknecht; Jonas Waider; Stefanie Kraft; Claudia Kriegebaum; Bettina Holtmann; Andreas Reif; Angelika Schmitt; Klaus-Peter Lesch
Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(8):1127-32.
2008: Ralf A Linker; Niels Kruse; Stephanie Israel; Tao Wei; S Seubert; Anja Hombach; Bettina Holtmann; Fred Luhder; Richard M Ransohoff; Michael Sendtner; Ralf Gold
Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2204-13.
2007: Alexandra Matzke; Vardanush Sargsyan; Bettina Holtmann; Gayane Aramuni; Esther Asan; Michael Sendtner; Giuseppina Pace; Norma Howells; Weiqi Zhang; Helmut Ponta; Véronique Orian-Rousseau
Haploinsufficiency of c-Met in cd44-/- mice identifies a collaboration of CD44 and c-Met in vivo.
Molecular and cellular biology 2007;27(24):8797-806.
2007: Stefan Wiese; Sibylle Jablonka; Bettina Holtmann; Nadiya Orel; Rithwick Rajagopal; Moses V Chao; Michael Sendtner
Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17210-5.
2007: Silke Schreiner; François Cossais; Kerstin Fischer; Stefanie Scholz; Michael R Bösl; Bettina Holtmann; Michael Sendtner; Michael Wegner
Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages.
Development (Cambridge, England) 2007;134(18):3271-81.
2007: Juan M Marquès; Idoia Belza; Bettina Holtmann; Diane Pennica; Jesus Prieto; Matilde Bustos
Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis.
Hepatology (Baltimore, Md.) 2007;45(3):639-48.
2006: Stephan Oberle; Andreas Schober; Verena Meyer; Bettina Holtmann; Christopher Henderson; Michael Sendtner; Klaus Unsicker
Loss of leukemia inhibitory factor receptor beta or cardiotrophin-1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(6):1823-32.
2005: Andreas Fischer; Jürgen Klattig; Burkhard Kneitz; Holger Diez; Manfred Maier; Bettina Holtmann; Christoph Englert; Manfred Gessler
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.
Molecular and cellular biology 2005;25(20):8960-70.
2005: Rudolf Götz; Stefan Wiese; Shinichi Takayama; Guadalupe Camarero; wilfried rossoll; Ulrich Schweizer; Jakob Troppmair; Sibylle Jablonka; Bettina Holtmann; John C Reed; Ulf R Rapp; Michael Sendtner
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Nature neuroscience 2005;8(9):1169-78.
2005: Bettina Holtmann; Stefan Wiese; Mohtashem Samsam; Katja Grohmann; Diane Pennica; Rudolf Martini; Michael Sendtner
Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(7):1778-87.
2005: Tobias Langenhan; Michael Sendtner; Bettina Holtmann; P Carroll; Esther Asan
Ciliary neurotrophic factor-immunoreactivity in olfactory sensory neurons.
Neuroscience 2005;134(4):1179-94.
2004: Matthias Hartmann; Tanja Brigadski; Kai S Erdmann; Bettina Holtmann; Michael Sendtner; Frank Narz; Volkmar Lessmann
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.
Journal of cell science 2004;117(Pt 24):5803-14.
2004: Katja Grohmann; wilfried rossoll; Igor Kobsar; Bettina Holtmann; Sibylle Jablonka; Carsten Wessig; Gisela Stoltenburg-Didinger; Utz Fischer; Christoph Hübner; Rudolf Martini; Michael Sendtner
Characterization of Ighmbp2 in motor neurons and implications for the pathomechanism in a mouse model of human spinal muscular atrophy with respiratory distress type 1 (SMARD1).
Human molecular genetics 2004;13(18):2031-42.
2003: Kliment P Gatzinsky; Bettina Holtmann; Babak Daraie; Claes-Henric Berthold; Michael Sendtner
Early onset of degenerative changes at nodes of Ranvier in alpha-motor axons of Cntf null (-/-) mutant mice.
Glia 2003;42(4):340-9.
2003: Lutz Schomburg; Ulrich Schweizer; Bettina Holtmann; Leopold Flohé; Michael Sendtner; Josef Köhrle
Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
The Biochemical journal 2003;370(Pt 2):397-402.
2003: Esther Asan; Tobias Langenhan; Bettina Holtmann; H Bock; Michael Sendtner; P Carroll
Ciliary neurotrophic factor in the olfactory bulb of rats and mice.
Neuroscience 2003;120(1):99-112.
2002: Sibylle Jablonka; Bettina Holtmann; Gunter Meister; Michael Bandilla; wilfried rossoll; Utz Fischer; Michael Sendtner
Gene targeting of Gemin2 in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10126-31.
2002: Ralf A Linker; Mathias Mäurer; Stefanie Gaupp; Rudolf Martini; Bettina Holtmann; Ralf Giess; Peter Rieckmann; Hans Lassmann; Klaus V Toyka; Michael Sendtner; Ralf Gold
CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation.
Nature medicine 2002;8(6):620-4.
2002: Ralf Giess; Bettina Holtmann; Massimiliano Braga; Tiemo Grimm; Bertram Müller-Myhsok; Klaus V Toyka; Michael Sendtner
Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene.
American journal of human genetics 2002;70(5):1277-86.
2002: Ulrich Schweizer; Jennifer Gunnersen; Christoph Karch; Stefan Wiese; Bettina Holtmann; Kiyoshi Takeda; Shizuo Akira; Michael Sendtner
Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult.
The Journal of cell biology 2002;156(2):287-97.
2001: Ronald W Oppenheim; Stefan Wiese; David Prevette; M Armanini; S Wang; Lucien J Houenou; Bettina Holtmann; R Gotz; Diane Pennica; Michael Sendtner
Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulations of developing motoneurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(4):1283-91.
2001: Stefan Wiese; G Pei; Christoph Karch; Jakob Troppmair; Bettina Holtmann; Ulf R Rapp; Michael Sendtner
Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons.
Nature neuroscience 2001;4(2):137-42.
2000: Hiroshi Nishimune; Sophie Vasseur; Stefan Wiese; M C Birling; Bettina Holtmann; Michael Sendtner; Juan L Iovanna; Christopher E Henderson
Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway.
Nature cell biology 2000;2(12):906-14.
2000: Rainald Mössner; D Albert; A M Persico; T Hennig; Dominik Bengel; Bettina Holtmann; Angelika Schmitt; Flavio Keller; Rabi Simantov; D Murphy; I Seif; Jürgen Deckert; Klaus-Peter Lesch
Differential regulation of adenosine A(1) and A(2A) receptors in serotonin transporter and monoamine oxidase A-deficient mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2000;10(6):489-93.
1999: Stefan Wiese; M R Digby; Jennifer Gunnersen; Rudolf Götz; G Pei; Bettina Holtmann; John W Lowenthal; Michael Sendtner
The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons.
Nature neuroscience 1999;2(11):978-83.
1999: Bettina Holtmann; Jürgen Zielasek; Klaus V Toyka; Michael Sendtner
Comparative analysis of motoneuron loss and functional deficits in PMN mice: implications for human motoneuron disease.
Journal of the neurological sciences 1999;169(1-2):140-7.
1999: Stefan Wiese; Friedrich Metzger; Bettina Holtmann; Michael Sendtner
The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons.
The European journal of neuroscience 1999;11(5):1668-76.
1999: Stefan Wiese; Friedrich Metzger; Bettina Holtmann; Michael Sendtner
Mechanical and excitotoxic lesion of motoneurons: effects of neurotrophins and ciliary neurotrophic factor on survival and regeneration.
Acta neurochirurgica. Supplement 1999;73():31-9.
1997: Michael Sendtner; Rudolf Götz; Bettina Holtmann; Hans Thoenen
Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6999-7006.
1996: Michael Sendtner; Bettina Holtmann; R A Hughes
The response of motoneurons to neurotrophins.
Neurochemical research 1996;21(7):831-41.
1996: T M Michaelidis; Michael Sendtner; J D Cooper; M S Airaksinen; Bettina Holtmann; M Meyer; H Thoenen
Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development.
Neuron 1996;17(1):75-89.
1996: Michael Sendtner; Rudolf Götz; Bettina Holtmann; J L Escary; Y Masu; P Carroll; E Wolf; Gottfried Brem; P Brület; H Thoenen
Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF.
Current biology : CB 1996;6(6):686-94.
1996: Ben A Barres; J F Burne; Bettina Holtmann; H Thoenen; Michael Sendtner; Martin Raff
Ciliary neurotrophic factor enhances the rate of oligodendrocyte generation.
Molecular and cellular neurosciences 1996;8(2-3):146-56.
1995: Michael Sendtner; R A Hughes; F Dittrich; Bettina Holtmann; Y Masu; P Carroll; G Ochs; Klaus V Toyka; H Thoenen
Ciliary neurotrophic factor (CNTF): physiological and pharmacological effects.
Restorative neurology and neuroscience 1995;8(1):95-6.
1994: Michael Sendtner; P Carroll; Bettina Holtmann; R A Hughes; H Thoenen
Ciliary neurotrophic factor.
Journal of neurobiology 1994;25(11):1436-53.
1993: Y Masu; E Wolf; Bettina Holtmann; Michael Sendtner; Gottfried Brem; H Thoenen
Disruption of the CNTF gene results in motor neuron degeneration.
Nature 1993;365(6441):27-32.
1992: Michael Sendtner; Bettina Holtmann; Roland W Kolbeck; H Thoenen; Yves-Alain Barde
Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section.
Nature 1992;360(6406):757-9.