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Wolfgang Holtmeier

Research Profile

Chemicals & Drugs

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delta-Chain T-Cell Antigen Receptor Gene Rearrangement

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Carsten Skarke; Lars Tausch; Oliver Werz; Jeffrey S Barrett; Sebastian Harder; Wolfgang Holtmeier; Karina Kuczka; Tanja Rossmanith; Joachim A Schwarz
Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.
Lars Tausch; Arne Henkel; Ulf Siemoneit; Daniel Poeckel; Nicole Kather; Lutz Franke; Bettina Hofmann; Gisbert Schneider; Carlo Angioni; Gerd Geisslinger; Carsten Skarke; Wolfgang Holtmeier; Tobias Beckhaus; Michael Karas; Johann Jauch; Oliver Werz
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
Markus Meissner; Andreas Pinter; Despina Michailidou; Igor Hrgovic; Natalia Kaprolat; Monika Stein; Wolfgang Holtmeier; Roland Kaufmann; Jens Gille
Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms.

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All Publications

2012: Carsten Skarke; Lars Tausch; Oliver Werz; Jeffrey S Barrett; Sebastian Harder; Wolfgang Holtmeier; Karina Kuczka; Tanja Rossmanith; Joachim A Schwarz
Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.
Journal of clinical pharmacology 2012;52(10):1592-600.
2009: Lars Tausch; Arne Henkel; Ulf Siemoneit; Daniel Poeckel; Nicole Kather; Lutz Franke; Bettina Hofmann; Gisbert Schneider; Carlo Angioni; Gerd Geisslinger; Carsten Skarke; Wolfgang Holtmeier; Tobias Beckhaus; Michael Karas; Johann Jauch; Oliver Werz
Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):3433-42.
2008: Markus Meissner; Andreas Pinter; Despina Michailidou; Igor Hrgovic; Natalia Kaprolat; Monika Stein; Wolfgang Holtmeier; Roland Kaufmann; Jens Gille
Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms.
The Journal of investigative dermatology 2008;128(8):2084-91.
2007: Hubert Allgayer; Wolfgang Holtmeier; Christoph F Dietrich
[Crohn's disease and cancer risk. Incidence/prevalence, clinical characteristics, and potential prevention strategies].
Medizinische Klinik (Munich, Germany : 1983) 2007;102(9):727-33.
2007: Wolfgang Holtmeier; Gerald Holtmann; Wolfgang F Caspary; Ulrike Weingärtner
On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study.
Journal of clinical gastroenterology 2007;41(6):564-70.
2007: Marek Sinkora; Jana Sinkorová; Zdenek Cimburek; Wolfgang Holtmeier
Two groups of porcine TCRgammadelta+ thymocytes behave and diverge differently.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(2):711-9.
2006: Wolfgang Holtmeier
[Treatment and management of celiac disease].
Zeitschrift für Gastroenterologie 2006;44(11):1167-75.
2006: John E Butler; Marek Sinkora; Nancy Wertz; Wolfgang Holtmeier; Caitlin D Lemke
Development of the neonatal B and T cell repertoire in swine: implications for comparative and veterinary immunology.
Veterinary research 2006;37(3):417-41.
2006: Wolfgang Holtmeier; Wolfgang F Caspary
Celiac disease.
Orphanet journal of rare diseases 2006;1():3.
2005: Wolfgang Holtmeier
[Diagnosis of celiac disease].
Zeitschrift für Gastroenterologie 2005;43(11):1243-52.
2005: Marek Sinkora; John E Butler; Wolfgang Holtmeier; Jana Sinkorova
Lymphocyte development in fetal piglets: facts and surprises.
Veterinary immunology and immunopathology 2005;108(1-2):177-84.
2005: Wolfgang Holtmeier; Jobst Henker; E O Riecken; K-P Zimmer
[Definitions of celiac disease--statement of an expert group from the German Society for Celiac Disease].
Zeitschrift für Gastroenterologie 2005;43(8):751-4.
2005: Marek Sinkora; Jana Sinkorová; Wolfgang Holtmeier
Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny.
Immunology 2005;115(4):544-55.
2005: Dieter Kabelitz; Lothar Marischen; Hans-Heinrich Oberg; Wolfgang Holtmeier; Daniela Wesch
Epithelial defence by gamma delta T cells.
International archives of allergy and immunology 2005;137(1):73-81.
2005: Wolfgang Holtmeier; Dieter Kabelitz
gammadelta T cells link innate and adaptive immune responses.
Chemical immunology and allergy 2005;86():151-83.
2004: Wolfgang Holtmeier; Wiebke Geisel; Kerstin Bernert; John E Butler; Marek Sinkora; Zuzana Reháková; Jiri Sinkora; Wolfgang F Caspary
Prenatal development of the porcine TCR delta repertoire: dominant expression of an invariant T cell receptor Vdelta3-Jdelta3 chain.
European journal of immunology 2004;34(7):1941-9.
2003: Karl-Heinz Thielke; Astrid Hoffmann-Moujahid; Clemens Weisser; Eginhard Waldkirch; Reinhard Pabst; Wolfgang Holtmeier; Hermann-Josef Rothkötter
Proliferating intestinal gamma/delta T cells recirculate rapidly and are a major source of the gamma/delta T cell pool in the peripheral blood.
European journal of immunology 2003;33(6):1649-56.
2003: Ralf J Ludwig; Marcella Grundmann-Kollmann; Wolfgang Holtmeier; Manfred Wolter; Jennifer Glas; Maurizio Podda; Roland Kaufmann; Thomas M Zollner
Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells' syndrome).
Journal of the American Academy of Dermatology 2003;48(5 Suppl):S60-1.
2003: Wolfgang Holtmeier
Compartmentalization gamma/delta T cells and their putative role in mucosal immunity.
Critical reviews in immunology 2003;23(5-6):473-88.
2002: Wolfgang Holtmeier; Michael Pfänder; Thomas M Zollner; Roland Kaufmann; Wolfgang F Caspary
Distinct TCR delta repertoires are present in the cutaneous lesions and inflamed duodenum of patients with dermatitis herpetiformis.
Experimental dermatology 2002;11(6):527-31.
2002: Wolfgang Holtmeier; Judith Käller; Wiebke Geisel; Reinhard Pabst; Wolfgang F Caspary; Hermann-Josef Rothkötter
Development and compartmentalization of the porcine TCR delta repertoire at mucosal and extraintestinal sites: the pig as a model for analyzing the effects of age and microbial factors.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1993-2002.
2002: Ekkehard May; Carsten Lambert; Wolfgang Holtmeier; Andreas Hennemann; Martin Zeitz; Rainer Duchmann
Regional variation of the alphabeta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease.
Human immunology 2002;63(6):467-80.
2002: Wolfgang Holtmeier; Andreas Hennemann; Ekkehard May; Rainer Duchmann; Wolfgang F Caspary
T cell receptor delta repertoire in inflamed and noninflamed colon of patients with IBD analyzed by CDR3 spectratyping.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(6):G1024-34.
2001: W P Hofmann; Christoph F Dietrich; Wolfgang Holtmeier; Wolfgang F Caspary; Stefan Zeuzem
[Hypertransaminasaemia and impaired liver function in a patient with oligosymptomatic celiac disease].
Zeitschrift für Gastroenterologie 2001;39(12):1027-32.
2001: Wolfgang Holtmeier; M Pfänder; Andreas Hennemann; Thomas M Zollner; Roland Kaufmann; Wolfgang F Caspary
The TCR-delta repertoire in normal human skin is restricted and distinct from the TCR-delta repertoire in the peripheral blood.
The Journal of investigative dermatology 2001;116(2):275-80.
2000: Wolfgang Holtmeier; Andreas Hennemann; Wolfgang F Caspary
IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated.
Gastroenterology 2000;119(5):1253-66.
1998: Wolfgang Holtmeier; Wolfgang F Caspary
[Antibody diagnosis iin sprue/celiac disease].
Zeitschrift für Gastroenterologie 1998;36(7):587-97.
1998: Wolfgang Holtmeier; Wolfgang F Caspary
[Diagnosis of sprue/celiac disease].
Deutsche medizinische Wochenschrift (1946) 1998;123(11):338-9.
1997: Wolfgang Holtmeier; T Witthöft; Andreas Hennemann; H S Winter; Martin F Kagnoff
The TCR-delta repertoire in human intestine undergoes characteristic changes during fetal to adult development.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5632-41.
1997: Wolfgang Holtmeier; D L Rowell; A Nyberg; Martin F Kagnoff
Distinct delta T cell receptor repertoires in monozygotic twins concordant for coeliac disease.
Clinical and experimental immunology 1997;107(1):148-57.
1995: Wolfgang Holtmeier; Y Chowers; A Lumeng; E Morzycka-Wroblewska; Martin F Kagnoff
The delta T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage.
The Journal of clinical investigation 1995;96(2):1108-17.
1995: Y Chowers; Wolfgang Holtmeier; E Morzycka-Wroblewska; Martin F Kagnoff
Inverse PCR amplification of rare T cell receptor delta messages from mucosal biopsy specimens.
Journal of immunological methods 1995;179(2):261-3.
1994: Y Chowers; Wolfgang Holtmeier; J Harwood; E Morzycka-Wroblewska; Martin F Kagnoff
The V delta 1 T cell receptor repertoire in human small intestine and colon.
The Journal of experimental medicine 1994;180(1):183-90.