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David Holtzclaw

Research Profile

Chemicals & Drugs

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Enzyme Induction

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Publications

TOP 3
Jed W Fahey; W David Holtzclaw; Thomas W Kensler; Theresa A Shapiro; Patricia A Egner; Scott L Wehage; Paul Talalay
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.
Zachary R Healy; W David Holtzclaw; Hua Liu; Paul Talalay
Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.
Theresa A Shapiro; Jed W Fahey; Albena T Dinkova-Kostova; W David Holtzclaw; Katherine K Stephenson; Kristina L Wade; Lingxiang Ye; Paul Talalay
Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

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All Publications

2012: Jed W Fahey; W David Holtzclaw; Thomas W Kensler; Theresa A Shapiro; Patricia A Egner; Scott L Wehage; Paul Talalay
Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):603-11.
2011: Zachary R Healy; W David Holtzclaw; Hua Liu; Paul Talalay
Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(7):1516-23.
2006: Theresa A Shapiro; Jed W Fahey; Albena T Dinkova-Kostova; W David Holtzclaw; Katherine K Stephenson; Kristina L Wade; Lingxiang Ye; Paul Talalay
Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.
Nutrition and cancer 2006;55(1):53-62.
2005: Albena T Dinkova-Kostova; W David Holtzclaw; Thomas W Kensler
The role of Keap1 in cellular protective responses.
Chemical research in toxicology 2005;18(12):1779-91.
2005: Albena T Dinkova-Kostova; W David Holtzclaw; Nobunao Wakabayashi
Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.
Biochemistry 2005;44(18):6889-99.
2005: Albena T Dinkova-Kostova; Karen T Liby; Katherine K Stephenson; W David Holtzclaw; Xiangqun Gao; Nanjoo Suh; Charlotte Williams; Renee Risingsong; Tadashi Honda; Gordon W Gribble; Michael B. Sporn; Paul Talalay
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4584-9.
2004: Nobunao Wakabayashi; Albena T Dinkova-Kostova; W David Holtzclaw; MOON-IL KANG; Akira Kobayashi; Masayuki Yamamoto; Thomas W Kensler; Paul Talalay
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):2040-5.
2004: W David Holtzclaw; Albena T Dinkova-Kostova; Paul Talalay
Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.
Advances in enzyme regulation 2004;44():335-67.
2003: Paul Talalay; Albena T Dinkova-Kostova; W David Holtzclaw
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.
Advances in enzyme regulation 2003;43():121-34.
2002: Albena T Dinkova-Kostova; W David Holtzclaw; Robert N Cole; Ken Itoh; Nobunao Wakabayashi; Yasutake Katoh; Masayuki Yamamoto; Paul Talalay
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11908-13.
1999: M Shikita; Jed W Fahey; TR Golden; W David Holtzclaw; Paul Talalay
An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings.
The Biochemical journal 1999;341 ( Pt 3)():725-32.
1997: Q Zhao; X L Yang; W David Holtzclaw; Paul Talalay
Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1669-74.
1996: T Prestera; Jed W Fahey; W David Holtzclaw; C Abeygunawardana; J L Kachinski; Paul Talalay
Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates.
Analytical biochemistry 1996;239(2):168-79.
1995: Paul Talalay; Jed W Fahey; W David Holtzclaw; T Prestera; Y Zhang
Chemoprotection against cancer by phase 2 enzyme induction.
Toxicology letters 1995;82-83():173-9.
1995: R R Putzer; Y Zhang; T Prestera; W David Holtzclaw; K L Wade; Paul Talalay
Mercurials and dimercaptans: synergism in the induction of chemoprotective enzymes.
Chemical research in toxicology 1995;8(1):103-10.
1993: T Prestera; W David Holtzclaw; Y Zhang; Paul Talalay
Chemical and molecular regulation of enzymes that detoxify carcinogens.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2965-9.
1989: W David Holtzclaw; G B Gordon
Measurement of serum levels of dehydroepiandrosterone sulfate: a comparison of radioimmunoassay and enzymatic analysis.
Steroids 1989;54(4):355-71.
1989: DW Payne; W David Holtzclaw; Eli Y Adashi
A convenient, unified scheme for the differential extraction of conjugated and unconjugated serum C19 steroids on Sep-Pak C18-cartridges.
Journal of steroid biochemistry 1989;33(2):289-95.
1988: DW Payne; W David Holtzclaw; Eli Y Adashi
The steroidogenic characteristics of primary testicular cell cultures from adult hypophysectomized rats: enhanced formation of C21 steroids.
Biology of reproduction 1988;39(3):581-91.
1988: E R Hernandez; Carol E Resnick; W David Holtzclaw; DW Payne; Eli Y Adashi
Insulin as a regulator of androgen biosynthesis by cultured rat ovarian cells: cellular mechanism(s) underlying physiological and pharmacological hormonal actions.
Endocrinology 1988;122(5):2034-43.