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David Holtzman
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33
Paul, Steven
31
Fagan, Anne
29
Bales, Kelly
22
Mobley, William C.
19
DeMattos, Ronald
19
Parsadanian, Maia
17
Cirrito, John
16
Bu, Guojun
15
Morris, John
11
Fryer, John
10
Mulkern, Robert
9
Li, Yiwen
8
Wahrle, Suzanne
8
Shah, Aarti
8
Khait, I
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All Publications
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2009: Perrin Richard J; Fagan Anne M; Holtzman David M
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease.
Nature 2009;461(7266):916-22.
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2009: Yuede Carla M; Zimmerman Scott D; Dong Hongxin; Kling Matthew J; Bero Adam W; Holtzman David M; Timson Benjamin F; Csernansky John G
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Neurobiology of disease 2009;35(3):426-32.
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2009: Yan Ping; Bero Adam W; Cirrito John R; Xiao Qingli; Hu Xiaoyan; Wang Yan; Gonzales Ernesto; Holtzman David M; Lee Jin-Moo
Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10706-14.
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2009: Kim Jungsu; Basak Jacob M; Holtzman David M
The role of apolipoprotein E in Alzheimer's disease.
Neuron 2009;63(3):287-303.
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2009: Craig-Schapiro Rebecca; Fagan Anne M; Holtzman David M
Biomarkers of Alzheimer's disease.
Neurobiology of disease 2009;35(2):128-40.
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2009: Cao Chuanhai; Cirrito John R; Lin Xiaoyang; Wang Lilly; Verges Deborah K; Dickson Alexander; Mamcarz Malgorzata; Zhang Chi; Mori Takashi; Arendash Gary W; Holtzman David M; Potter Huntington
Caffeine Suppresses Amyloid-beta Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice.
Journal of Alzheimer's disease : JAD 2009;17(3):681-97.
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2009: Britschgi M; Olin C E; Johns H T; Takeda-Uchimura Y; LeMieux M C; Rufibach K; Rajadas J; Zhang H; Tomooka B; Robinson W H; Clark C M; Fagan A M; Galasko D R; Holtzman D M; Jutel M; Kaye J A; Lemere C A; Leszek J; Li G; Peskind E R; Quinn J F; Yesavage J A; Ghiso J A; Wyss-Coray T
Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12145-50.
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2009: Bateman Randall J; Siemers Eric R; Mawuenyega Kwasi G; Wen Guolin; Browning Karen R; Sigurdson Wendy C; Yarasheski Kevin E; Friedrich Stuart W; Demattos Ronald B; May Patrick C; Paul Steven M; Holtzman David M
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
Annals of neurology 2009;66(1):48-54.
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2009: Snider Barbara J; Fagan Anne M; Roe Catherine; Shah Aarti R; Grant Elizabeth A; Xiong Chengjie; Morris John C; Holtzman David M
Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type.
Archives of neurology 2009;66(5):638-45.
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2009: Tarawneh Rawan; Holtzman David M
Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention.
CNS & neurological disorders drug targets 2009;8(2):144-59.
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2009: Mandrekar Shweta; Jiang Qingguang; Lee C Y Daniel; Koenigsknecht-Talboo Jessica; Holtzman David M; Landreth Gary E
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(13):4252-62.
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2009: Fagan Anne M; Head Denise; Shah Aarti R; Marcus Daniel; Mintun Mark; Morris John C; Holtzman David M
Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.
Annals of neurology 2009;65(2):176-83.
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2009: Kauwe John S K; Wang Jun; Mayo Kevin; Morris John C; Fagan Anne M; Holtzman David M; Goate Alison M
Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
Neurogenetics 2009;10(1):13-7.
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2009: West Tim; Stump Madeliene; Lodygensky Gregory; Neil Jeff J; Deshmukh Mohanish; Holtzman David M
Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.
ASN neuro 2009;1(1):.
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2008: Koenigsknecht-Talboo Jessica; Meyer-Luehmann Melanie; Parsadanian Maia; Garcia-Alloza Monica; Finn Mary Beth; Hyman Bradley T; Bacskai Brian J; Holtzman David M
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14156-64.
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2008: Han Byung Hee; Zhou Meng-Liang; Abousaleh Fadi; Brendza Robert P; Dietrich Hans H; Koenigsknecht-Talboo Jessica; Cirrito John R; Milner Eric; Holtzman David M; Zipfel Gregory J
Cerebrovascular dysfunction in amyloid precursor protein transgenic mice: contribution of soluble and insoluble amyloid-beta peptide, partial restoration via gamma-secretase inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(50):13542-50.
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2008: Deane Rashid; Sagare Abhay; Hamm Katie; Parisi Margaret; Lane Steven; Finn Mary Beth; Holtzman David M; Zlokovic Berislav V
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
The Journal of clinical investigation 2008;118(12):4002-13.
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2008: Yamada Kaoru; Hashimoto Tadafumi; Yabuki Chiori; Nagae Yusuke; Tachikawa Masanori; Strickland Dudley K; Liu Qiang; Bu Guojun; Basak Jacob M; Holtzman David M; Ohtsuki Sumio; Terasaki Tetsuya; Iwatsubo Takeshi
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
The Journal of biological chemistry 2008;283(50):34554-62.
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2008: Brody David L; Magnoni Sandra; Schwetye Kate E; Spinner Michael L; Esparza Thomas J; Stocchetti Nino; Zipfel Gregory J; Holtzman David M
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Science (New York, N.Y.) 2008;321(5893):1221-4.
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2008: Maysinger Dusica; Holmes Michael; Han Xianlin; Epand Richard M; Pertens Evi; Foerster Anne; Barlas Cia; Holtzman David M; Diamond Jack
Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(31):7891-9.
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2008: Holtzman David M
Alzheimer's disease: Moving towards a vaccine.
Nature 2008;454(7203):418-20.
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2008: Holtzman David
Autistic spectrum disorders and mitochondrial encephalopathies.
Acta paediatrica (Oslo, Norway : 1992) 2008;97(7):859-60.
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2008: Jiang Qingguang; Lee C Y Daniel; Mandrekar Shweta; Wilkinson Brandy; Cramer Paige; Zelcer Noam; Mann Karen; Lamb Bruce; Willson Timothy M; Collins Jon L; Richardson Jill C; Smith Jonathan D; Comery Thomas A; Riddell David; Holtzman David M; Tontonoz Peter; Landreth Gary E
ApoE promotes the proteolytic degradation of Abeta.
Neuron 2008;58(5):681-93.
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2008: Kauwe John S K; Cruchaga Carlos; Mayo Kevin; Fenoglio Chiara; Bertelsen Sarah; Nowotny Petra; Galimberti Daniela; Scarpini Elio; Morris John C; Fagan Anne M; Holtzman David M; Goate Alison M
Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8050-4.
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2008: Wendland Michael F; Faustino Joel; West Tim; Manabat Catherine; Holtzman David M; Vexler Zinaida S
Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents.
Stroke; a journal of cerebral circulation 2008;39(6):1862-8.
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2008: Cirrito John R; Kang Jae-Eun; Lee Jiyeon; Stewart Floy R; Verges Deborah K; Silverio Luz M; Bu Guojun; Mennerick Steven; Holtzman David M
Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.
Neuron 2008;58(1):42-51.
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2008: Meyer-Luehmann Melanie; Spires-Jones Tara L; Prada Claudia; Garcia-Alloza Monica; de Calignon Alix; Rozkalne Anete; Koenigsknecht-Talboo Jessica; Holtzman David M; Bacskai Brian J; Hyman Bradley T
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature 2008;451(7179):720-4.
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2008: Wahrle Suzanne E; Jiang Hong; Parsadanian Maia; Kim Jungsu; Li Aimin; Knoten Amanda; Jain Sanjay; Hirsch-Reinshagen Veronica; Wellington Cheryl L; Bales Kelly R; Paul Steven M; Holtzman David M
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.
The Journal of clinical investigation 2008;118(2):671-82.
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2008: Wippold F J; Cairns N; Vo K; Holtzman D M; Morris J C
Neuropathology for the neuroradiologist: plaques and tangles.
AJNR. American journal of neuroradiology 2008;29(1):18-22.
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2008: Brody David L; Holtzman David M
Active and passive immunotherapy for neurodegenerative disorders.
Annual review of neuroscience 2008;31():175-93.
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2007: Zeng Ling-Hui; Ouyang Yannan; Gazit Vered; Cirrito John R; Jansen Laura A; Ess Kevin C; Yamada Kelvin A; Wozniak David F; Holtzman David M; Gutmann David H; Wong Michael
Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex.
Neurobiology of disease 2007;28(2):184-96.
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2007: Mac Donald Christine L; Dikranian Krikor; Bayly Philip; Holtzman David; Brody David
Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(44):11869-76.
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2007: Farris Wesley; Schütz Sonja G; Cirrito John R; Shankar Ganesh M; Sun Xiaoyan; George Ana; Leissring Malcolm A; Walsh Dominic M; Qiu Wei Qiao; Holtzman David M; Selkoe Dennis J
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
The American journal of pathology 2007;171(1):241-51.
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2007: Gelfanova Valentina; Higgs Richard E; Dean Robert A; Holtzman David M; Farlow Martin R; Siemers Eric R; Boodhoo Amechand; Qian Yue-Wei; He Xiaohua; Jin Zhaoyan; Fisher Deborah L; Cox Karen L; Hale John E
Quantitative analysis of amyloid-beta peptides in cerebrospinal fluid using immunoprecipitation and MALDI-Tof mass spectrometry.
Briefings in functional genomics & proteomics 2007;6(2):149-58.
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2007: Kang Jae-Eun; Cirrito John R; Dong Hongxin; Csernansky John G; Holtzman David M
Acute stress increases interstitial fluid amyloid-beta via corticotropin-releasing factor and neuronal activity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10673-8.
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2007: Bateman Randall J; Munsell Ling Y; Chen Xianghong; Holtzman David M; Yarasheski Kevin E
Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates.
Journal of the American Society for Mass Spectrometry 2007;18(6):997-1006.
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2007: Mac Donald C L; Dikranian K; Song S K; Bayly P V; Holtzman D M; Brody D L
Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury.
Experimental neurology 2007;205(1):116-31.
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2007: Kauwe John S K; Jacquart Sarah; Chakraverty Sumi; Wang Jun; Mayo Kevin; Fagan Anne M; Holtzman David M; Morris John C; Goate Alison M
Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation.
Annals of neurology 2007;61(5):446-53.
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2007: Bell Robert D; Sagare Abhay P; Friedman Alan E; Bedi Gurrinder S; Holtzman David M; Deane Rashid; Zlokovic Berislav V
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(5):909-18.
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2007: Brody David L; Mac Donald Christine; Kessens Chad C; Yuede Carla; Parsadanian Maia; Spinner Mike; Kim Eddie; Schwetye Katherine E; Holtzman David M; Bayly Philip V
Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury.
Journal of neurotrauma 2007;24(4):657-73.
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2007: Holtzman David M
Pittsburgh compound B retention and verification of amyloid deposition.
Archives of neurology 2007;64(3):315-6.
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2007: Fagan Anne M; Roe Catherine M; Xiong Chengjie; Mintun Mark A; Morris John C; Holtzman David M
Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults.
Archives of neurology 2007;64(3):343-9.
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2007: Bateman Randall J; Wen Guolin; Morris John C; Holtzman David M
Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.
Neurology 2007;68(9):666-9.
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2007: West Tim; Atzeva Madeliene; Holtzman David M
Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury.
Developmental neuroscience 2007;29(4-5):363-72.
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2007: Wahrle Suzanne E; Shah Aarti R; Fagan Anne M; Smemo Scott; Kauwe John S K; Grupe Andrew; Hinrichs Anthony; Mayo Kevin; Jiang Hong; Thal Leon J; Goate Alison M; Holtzman David M
Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms.
Molecular neurodegeneration 2007;2():7.
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2006: Csernansky John G; Dong Hongxin; Fagan Anne M; Wang Lei; Xiong Chengjie; Holtzman David M; Morris John C
Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia.
The American journal of psychiatry 2006;163(12):2164-9.
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2006: Hartman Richard E; Shah Aartie; Fagan Anne M; Schwetye Katherine E; Parsadanian Maia; Schulman Risa N; Finn Mary Beth; Holtzman David M
Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease.
Neurobiology of disease 2006;24(3):506-15.
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2006: Zerbinatti Celina V; Wahrle Suzanne E; Kim Hyungjin; Cam Judy A; Bales Kelly; Paul Steven M; Holtzman David M; Bu Guojun
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.
The Journal of biological chemistry 2006;281(47):36180-6.
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2006: Yin Ke-Jie; Cirrito John R; Yan Ping; Hu Xiaoyan; Xiao Qingli; Pan Xiaoou; Bateman Randall; Song Haowei; Hsu Fong-Fu; Turk John; Xu Jan; Hsu Chung Y; Mills Jason C; Holtzman David M; Lee Jin-Moo
Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):10939-48.
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2006: Schlief Michelle L; West Tim; Craig Ann Marie; Holtzman David M; Gitlin Jonathan D
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14919-24.
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2006: Hachinski Vladimir; Iadecola Costantino; Petersen Ron C; Breteler Monique M; Nyenhuis David L; Black Sandra E; Powers William J; DeCarli Charles; Merino Jose G; Kalaria Raj N; Vinters Harry V; Holtzman David M; Rosenberg Gary A; Wallin Anders; Dichgans Martin; Marler John R; Leblanc Gabrielle G
National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards.
Stroke; a journal of cerebral circulation 2006;37(9):2220-41.
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2006: Yan Ping; Hu Xiaoyan; Song Haowei; Yin Kejie; Bateman Randall J; Cirrito John R; Xiao Qingli; Hsu Fong F; Turk John W; Xu Jan; Hsu Chung Y; Holtzman David M; Lee Jin-Moo
Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ.
The Journal of biological chemistry 2006;281(34):24566-74.
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2006: Bateman Randall J; Munsell Ling Y; Morris John C; Swarm Robert; Yarasheski Kevin E; Holtzman David M
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo.
Nature medicine 2006;12(7):856-61.
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2006: West Tim; Atzeva Madeliene; Holtzman David M
Caspase-3 deficiency during development increases vulnerability to hypoxic-ischemic injury through caspase-3-independent pathways.
Neurobiology of disease 2006;22(3):523-37.
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2006: Brendza Robert P; Holtzman David M
Amyloid-beta immunotherapies in mice and men.
Alzheimer disease and associated disorders 2006;20(2):118-23.
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2006: Wei Ling; Han Byung H; Li Ying; Keogh Christine L; Holtzman David M; Yu Shan Ping
Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats.
The Journal of pharmacology and experimental therapeutics 2006;317(1):109-16.
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2006: Kotzbauer Paul T; Holtzman David M
Expectations and challenges in the therapeutic use of neurotrophic factors.
Annals of neurology 2006;59(3):444-7.
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2006: Fagan Anne M; Mintun Mark A; Mach Robert H; Lee Sang-Yoon; Dence Carmen S; Shah Aarti R; LaRossa Gina N; Spinner Michael L; Klunk William E; Mathis Chester A; DeKosky Steven T; Morris John C; Holtzman David M
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Annals of neurology 2006;59(3):512-9.
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2006: Siemers E R; Quinn J F; Kaye J; Farlow M R; Porsteinsson A; Tariot P; Zoulnouni P; Galvin J E; Holtzman D M; Knopman D S; Satterwhite J; Gonzales C; Dean R A; May P C
Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.
Neurology 2006;66(4):602-4.
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2006: Brody David L; Holtzman David M
Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury.
Experimental neurology 2006;197(2):330-40.
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2006: Momeni Parastoo; Schymick Jennifer; Jain Shushant; Cookson Mark R; Cairns Nigel J; Greggio Elisa; Greenway Matthew J; Berger Stephen; Pickering-Brown Stuart; Chiò Adriano; Fung Hon Chung; Holtzman David M; Huey Edward D; Wassermann Eric M; Adamson Jennifer; Hutton Michael L; Rogaeva Ekaterina; St George-Hyslop Peter; Rothstein Jeffrey D; Hardiman Orla; Grafman Jordan; Singleton Andrew; Hardy John; Traynor Bryan J
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
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2006: Oe Tomoyuki; Ackermann Bradley L; Inoue Koichi; Berna Michael J; Garner Carlos O; Gelfanova Valentina; Dean Robert A; Siemers Eric R; Holtzman David M; Farlow Martin R; Blair Ian A
Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2006;20(24):3723-35.
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2005: Cirrito John R; Yamada Kelvin A; Finn Mary Beth; Sloviter Robert S; Bales Kelly R; May Patrick C; Schoepp Darryle D; Paul Steven M; Mennerick Steven; Holtzman David M
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Neuron 2005;48(6):913-22.
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2005: Deane Rashid; Sagare Abhay; Hamm Katie; Parisi Margaret; LaRue Barbra; Guo Huang; Wu Zhenhua; Holtzman David M; Zlokovic Berislav V
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(50):11495-503.
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2005: Wahrle Suzanne E; Jiang Hong; Parsadanian Maia; Hartman Richard E; Bales Kelly R; Paul Steven M; Holtzman David M
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
The Journal of biological chemistry 2005;280(52):43236-42.
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2005: Hu Yan; Malone James P; Fagan Anne M; Townsend R Reid; Holtzman David M
Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.
Molecular & cellular proteomics : MCP 2005;4(12):2000-9.
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2005: Dickerson Bradford C; Holtzman David; Grant P Ellen; Tian Di
Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure, disturbed gait, and altered mental status.
The New England journal of medicine 2005;353(21):2271-80.
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2005: Cirrito John R; Deane Rashid; Fagan Anne M; Spinner Michael L; Parsadanian Maia; Finn Mary Beth; Jiang Hong; Prior Julie L; Sagare Abhay; Bales Kelly R; Paul Steven M; Zlokovic Berislav V; Piwnica-Worms David; Holtzman David M
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.
The Journal of clinical investigation 2005;115(11):3285-90.
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2005: Young Chainllie; Roth Kevin A; Klocke Barbara J; West Tim; Holtzman David M; Labruyere Joann; Qin Yue-Qin; Dikranian Krikor; Olney John W
Role of caspase-3 in ethanol-induced developmental neurodegeneration.
Neurobiology of disease 2005;20(2):608-14.
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2005: Morris John C; Kimberly A; Quaid K; Holtzman David M; Kantarci Kejal; Kaye Jeffrey; Reiman Eric M; Klunk William E; Siemers Eric R
Role of biomarkers in studies of presymptomatic Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2005;1(2):145-51.
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2005: Fryer John D; Holtzman David M
The bad seed in Alzheimer's disease.
Neuron 2005;47(2):167-8.
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2005: Fryer John D; Demattos Ronald B; McCormick Lynn M; O'Dell Mark A; Spinner Michael L; Bales Kelly R; Paul Steven M; Sullivan Patrick M; Parsadanian Maia; Bu Guojun; Holtzman David M
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
The Journal of biological chemistry 2005;280(27):25754-9.
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2005: Hartman Richard E; Izumi Yukitoshi; Bales Kelly R; Paul Steven M; Wozniak David F; Holtzman David M
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(26):6213-20.
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2005: Morikawa Masayuki; Fryer John D; Sullivan Patrick M; Christopher Erin A; Wahrle Suzanne E; DeMattos Ronald B; O'Dell Mark A; Fagan Anne M; Lashuel Hilal A; Walz Thomas; Asai Kiyofumi; Holtzman David M
Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta.
Neurobiology of disease 2005;19(1-2):66-76.
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2005: Loren David J; Seeram Navindra P; Schulman Risa N; Holtzman David M
Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.
Pediatric research 2005;57(6):858-64.
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2005: Fryer John D; Simmons Kelly; Parsadanian Maia; Bales Kelly R; Paul Steven M; Sullivan Patrick M; Holtzman David M
Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):2803-10.
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2005: Lee Jin-Moo; Yin Kejie; Hsin Idar; Chen Shawei; Fryer John D; Holtzman David M; Hsu Chung Y; Xu Jian
Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage.
Journal of the neurological sciences 2005;229-230():249-54.
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2005: Maas James W; Indacochea Ricardo A; Muglia Lisa M; Tran Timothy T; Vogt Sherri K; West Tim; Benz Ann; Shute Amanda A; Holtzman David M; Mennerick Steven; Olney John W; Muglia Louis J
Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(9):2376-85.
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2005: Brendza Robert P; Bacskai Brian J; Cirrito John R; Simmons Kelly A; Skoch Jesse M; Klunk William E; Mathis Chester A; Bales Kelly R; Paul Steven M; Hyman Bradley T; Holtzman David M
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
The Journal of clinical investigation 2005;115(2):428-33.
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2005: Racke Margaret M; Boone Laura I; Hepburn Deena L; Parsadainian Maia; Bryan Matthew T; Ness Daniel K; Piroozi Kathy S; Jordan William H; Brown Donna D; Hoffman Wherly P; Holtzman David M; Bales Kelly R; Gitter Bruce D; May Patrick C; Paul Steven M; DeMattos Ronald B
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(3):629-36.
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2005: Bennett David A; Holtzman David M
Immunization therapy for Alzheimer disease?
Neurology 2005;64(1):10-2.
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2005: Sun Shu-Wei; Song Sheng-Kwei; Harms Michael P; Lin Shiow-Jiuan; Holtzman David M; Merchant Kalpana M; Kotyk John J
Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging.
Experimental neurology 2005;191(1):77-85.
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2005: Fagan Anne M; Csernansky Cynthia A; Morris John C; Holtzman David M
The search for antecedent biomarkers of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2005;8(4):347-58.
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2004: Wei Xing; Zhao Liming; Ma Zhizhong; Holtzman David M; Yan Chong; Dodel Richard C; Hampel Harald; Oertel Wolfgang; Farlow Martin R; Du Yansheng
Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury.
Brain : a journal of neurology 2004;127(Pt 12):2629-35.
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2004: Fagan Anne M; Christopher Erin; Taylor Jennie W; Parsadanian Maia; Spinner Michael; Watson Melanie; Fryer John D; Wahrle Suzanne; Bales Kelly R; Paul Steven M; Holtzman David M
ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis.
The American journal of pathology 2004;165(4):1413-22.
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2004: Legleiter Justin; DeMattos Ronald B; Holtzman David M; Kowalewski Tomasz
In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteins.
Journal of colloid and interface science 2004;278(1):96-106.
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2004: Sadowski Marcin; Pankiewicz Joanna; Scholtzova Henrieta; Ripellino James A; Li Yongsheng; Schmidt Stephen D; Mathews Paul M; Fryer John D; Holtzman David M; Sigurdsson Einar M; Wisniewski Thomas
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
The American journal of pathology 2004;165(3):937-48.
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2004: Wahrle Suzanne E; Jiang Hong; Parsadanian Maia; Legleiter Justin; Han Xianlin; Fryer John D; Kowalewski Tomasz; Holtzman David M
ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.
The Journal of biological chemistry 2004;279(39):40987-93.
-
2004: Yao Jun; Petanceska Suzana S; Montine Thomas J; Holtzman David M; Schmidt Stephen D; Parker Carolyn A; Callahan Michael J; Lipinski William J; Bisgaier Charles L; Turner Brian A; Nixon Ralph A; Martins Ralph N; Ouimet Charles; Smith Jonathan D; Davies Peter; Laska Eugene; Ehrlich Michelle E; Walker Lary C; Mathews Paul M; Gandy Sam
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
Journal of neurochemistry 2004;90(4):1011-8.
-
2004: Song Sheng-Kwei; Kim Joong Hee; Lin Shiow-Jiuan; Brendza Robert P; Holtzman David M
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition.
Neurobiology of disease 2004;15(3):640-7.
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2004: Gandy Sam; DeMattos Ron B; Lemere Cynthia A; Heppner Frank L; Leverone Jodi; Aguzzi Adriano; Ershler William B; Dai Jinlu; Fraser Paul; St George Hyslop Peter; Holtzman David M; Walker Lary C; Keller Evan T
Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
Mechanisms of ageing and development 2004;125(2):149-51.
-
2004: Gandy Sam; DeMattos Ron B; Lemere Cynthia A; Heppner Frank L; Leverone Jodi; Aguzzi Adriano; Ershler William B; Dai Jinlu; Fraser Paul; Hyslop Peter St George; Holtzman David M; Walker Lary C; Keller Evan T
Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
Alzheimer disease and associated disorders 2004;18(1):44-6.
-
2004: DeMattos Ronald B; Cirrito John R; Parsadanian Maia; May Patrick C; O'Dell Mark A; Taylor Jennie W; Harmony Judith A K; Aronow Bruce J; Bales Kelly R; Paul Steven M; Holtzman David M
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
Neuron 2004;41(2):193-202.
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2004: Zerbinatti Celina V; Wozniak David F; Cirrito John; Cam Judy A; Osaka Hiroshi; Bales Kelly R; Zhuo Min; Paul Steven M; Holtzman David M; Bu Guojun
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(4):1075-80.
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2004: Legleiter Justin; Czilli Dan L; Gitter Bruce; DeMattos Ronald B; Holtzman David M; Kowalewski Tomasz
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Journal of molecular biology 2004;335(4):997-1006.
-
2004: Holtzman David M
In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology.
Journal of molecular neuroscience : MN 2004;23(3):247-54.
-
2003: Brendza Robert P; Simmons Kelly; Bales Kelly R; Paul Steven M; Goldberg Mark P; Holtzman David M
Use of YFP to study amyloid-beta associated neurite alterations in live brain slices.
Neurobiology of aging 2003;24(8):1071-7.
-
2003: Cirrito John R; May Patrick C; O'Dell Mark A; Taylor Jennie W; Parsadanian Maia; Cramer Jeffrey W; Audia James E; Nissen Jeffrey S; Bales Kelly R; Paul Steven M; DeMattos Ronald B; Holtzman David M
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(26):8844-53.
-
2003: Young C; Klocke B J; Tenkova T; Choi J; Labruyere J; Qin Y-Q; Holtzman D M; Roth K A; Olney J W
Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain.
Cell death and differentiation 2003;10(10):1148-55.
-
2003: Lemere Cynthia A; Spooner Edward T; LaFrancois John; Malester Brian; Mori Chica; Leverone Jodi F; Matsuoka Yasuji; Taylor Jennie W; DeMattos Ronald B; Holtzman David M; Clements John D; Selkoe Dennis J; Duff Karen E
Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.
Neurobiology of disease 2003;14(1):10-8.
-
2003: Wahrle Suzanne E; Holtzman David M
Differential metabolism of ApoE isoforms in plasma and CSF.
Experimental neurology 2003;183(1):4-6.
-
2003: Lee Jin-Moo; Yin Ke-Jie; Hsin Idar; Chen Shawei; Fryer John D; Holtzman David M; Hsu Chung Y; Xu Jian
Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy.
Annals of neurology 2003;54(3):379-82.
-
2003: Fryer John D; Taylor Jennie W; DeMattos Ronald B; Bales Kelly R; Paul Steven M; Parsadanian Maia; Holtzman David M
Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(21):7889-96.
-
2003: Cirrito John R; Holtzman David M
Amyloid beta and Alzheimer disease therapeutics: the devil may be in the details.
The Journal of clinical investigation 2003;112(3):321-3.
-
2003: Holtzman David M
Potential role of endogenous and exogenous amyloid-beta binding molecules in the pathogenesis, diagnosis, and treatment of Alzheimer disease.
Alzheimer disease and associated disorders 2003;17(3):151-3.
-
2003: Han Xianlin; Fagan Anne M; Cheng Hua; Morris John C; Xiong Chengjie; Holtzman David M
Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.
Annals of neurology 2003;54(1):115-9.
-
2003: Holtzman David M
Amyloid-beta binding molecule: potential role in the pathogenesis and treatment of Alzheimer disease.
Alzheimer disease and associated disorders 2003;17 Suppl 2():S66-8.
-
2003: Han Xianlin; Cheng Hua; Fryer John D; Fagan Anne M; Holtzman David M
Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content.
The Journal of biological chemistry 2003;278(10):8043-51.
-
2003: Brendza Robert P; O'Brien Cara; Simmons Kelly; McKeel Daniel W; Bales Kelly R; Paul Steven M; Olney John W; Sanes Joshua R; Holtzman David M
PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures.
The Journal of comparative neurology 2003;456(4):375-83.
-
2003: Zhuang Zhi-Ping; Kung Mei-Ping; Wilson Alan; Lee Chi-Wan; Plössl Karl; Hou Catherine; Holtzman David M; Kung Hank F
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
Journal of medicinal chemistry 2003;46(2):237-43.
-
2003: Manabat C; Han B H; Wendland M; Derugin N; Fox C K; Choi J; Holtzman D M; Ferriero D M; Vexler Z S
Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain.
Stroke; a journal of cerebral circulation 2003;34(1):207-13.
-
2003: Ji Y; Gong Y; Gan W; Beach T; Holtzman D M; Wisniewski T
Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.
Neuroscience 2003;122(2):305-15.
-
2002: Holtzman David M; Bales Kelly R; Paul Steven M; DeMattos Ronald B
Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease.
Advanced drug delivery reviews 2002;54(12):1603-13.
-
2002: Hartman Richard E; Laurer Helmut; Longhi Luca; Bales Kelly R; Paul Steven M; McIntosh Tracy K; Holtzman David M
Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(23):10083-7.
-
2002: Holtzman David M
Abeta conformational change is central to Alzheimer's disease.
Neurobiology of aging 2002;23(6):1085-8.
-
2002: Narita Masaaki; Holtzman David M; Fagan Anne M; LaDu Mary Jo; Yu Li; Han Xianlin; Gross Richard W; Bu Guojun; Schwartz Alan L
Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein.
Journal of biochemistry 2002;132(5):743-9.
-
2002: Bales K R; Dodart J C; DeMattos R B; Holtzman D M; Paul S M
Apolipoprotein E, amyloid, and Alzheimer disease.
Molecular interventions 2002;2(6):363-75, 339.
-
2002: DeMattos Ronald B; O'dell Mark A; Parsadanian Maia; Taylor Jennie W; Harmony Judith A K; Bales Kelly R; Paul Steven M; Aronow Bruce J; Holtzman David M
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10843-8.
-
2002: Han Byung Hee; Xu Daigen; Choi Junjeong; Han Yongxin; Xanthoudakis Steven; Roy Sophie; Tam John; Vaillancourt John; Colucci John; Siman Robert; Giroux Andre; Robertson George S; Zamboni Robert; Nicholson Donald W; Holtzman David M
Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.
The Journal of biological chemistry 2002;277(33):30128-36.
-
2002: Arvin Kara L; Han Byung H; Du Yansheng; Lin Sui-zhen; Paul Steven M; Holtzman David M
Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury.
Annals of neurology 2002;52(1):54-61.
-
2002: Koistinaho Milla; Kettunen Mikko I; Holtzman David M; Kauppinen Risto A; Higgins Linda S; Koistinaho Jari
Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility.
Stroke; a journal of cerebral circulation 2002;33(7):1905-10.
-
2002: Dodart Jean-Cosme; Bales Kelly R; Gannon Kimberley S; Greene Stephen J; DeMattos Ronald B; Mathis Chantal; DeLong Cynthia A; Wu Su; Wu Xin; Holtzman David M; Paul Steven M
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
Nature neuroscience 2002;5(5):452-7.
-
2002: DeMattos Ronald B; Bales Kelly R; Parsadanian Maia; O'Dell Mark A; Foss Eric M; Paul Steven M; Holtzman David M
Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.
Journal of neurochemistry 2002;81(2):229-36.
-
2002: Fagan Anne M; Watson Melanie; Parsadanian Maia; Bales Kelly R; Paul Steven M; Holtzman David M
Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
Neurobiology of disease 2002;9(3):305-18.
-
2002: Sims Katherine; Holtzman David
Diseases of adenosine triphosphate synthesis in children.
Current opinion in neurology 2002;15(2):145-50.
-
2002: DeMattos Ronald B; Bales Kelly R; Cummins David J; Paul Steven M; Holtzman David M
Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease.
Science (New York, N.Y.) 2002;295(5563):2264-7.
-
2002: Back Stephen A; Han Byung Hee; Luo Ning Ling; Chricton Charlene A; Xanthoudakis Steve; Tam John; Arvin Kara L; Holtzman David M
Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):455-63.
-
2002: Hee Han Byung; Choi Junjeong; Holtzman David M
Evidence that p38 mitogen-activated protein kinase contributes to neonatal hypoxic-ischemic brain injury.
Developmental neuroscience 2002;24(5):405-10.
-
2002: Brendza R P; Bales K R; Paul S M; Holtzman D M
Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models.
Molecular psychiatry 2002;7(2):132-5.
-
2001: Kekelidze T; Khait I; Togliatti A; Benzecry J M; Wieringa B; Holtzman D
Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent.
Journal of neuroscience research 2001;66(5):866-72.
-
2001: DeMattos R B; Brendza R P; Heuser J E; Kierson M; Cirrito J R; Fryer J; Sullivan P M; Fagan A M; Han X; Holtzman D M
Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice.
Neurochemistry international 2001;39(5-6):415-25.
-
2001: Holtzman D M
Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy.
Journal of molecular neuroscience : MN 2001;17(2):147-55.
-
2001: Gibson M E; Han B H; Choi J; Knudson C M; Korsmeyer S J; Parsadanian M; Holtzman D M
BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways.
Molecular medicine (Cambridge, Mass.) 2001;7(9):644-55.
-
2001: Hartman R E; Wozniak D F; Nardi A; Olney J W; Sartorius L; Holtzman D M
Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology.
Experimental neurology 2001;170(2):326-44.
-
2001: DeMattos R B; Bales K R; Cummins D J; Dodart J C; Paul S M; Holtzman D M
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8850-5.
-
2001: Han X; Holtzman D M; McKeel D W
Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry.
Journal of neurochemistry 2001;77(4):1168-80.
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2001: Han B H; DeMattos R B; Dugan L L; Kim-Han J S; Brendza R P; Fryer J D; Kierson M; Cirrito J; Quick K; Harmony J A; Aronow B J; Holtzman D M
Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.
Nature medicine 2001;7(3):338-43.
-
2001: Arredondo L R; Deng C; Ratts R B; Lovett-Racke A E; Holtzman D M; Racke M K
Role of nerve growth factor in experimental autoimmune encephalomyelitis.
European journal of immunology 2001;31(2):625-33.
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2000: Shibata M; Yamada S; Kumar S R; Calero M; Bading J; Frangione B; Holtzman D M; Miller C A; Strickland D K; Ghiso J; Zlokovic B V
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.
The Journal of clinical investigation 2000;106(12):1489-99.
-
2000: Almli C R; Levy T J; Han B H; Shah A R; Gidday J M; Holtzman D M
BDNF protects against spatial memory deficits following neonatal hypoxia-ischemia.
Experimental neurology 2000;166(1):99-114.
-
2000: Kekelidze T; Khait I; Togliatti A; Holtzman D
Brain creatine kinase and creatine transporter proteins in normal and creatine-treated rabbit pups.
Developmental neuroscience 2000;22(5-6):437-43.
-
2000: Ho N; Liauw J A; Blaeser F; Wei F; Hanissian S; Muglia L M; Wozniak D F; Nardi A; Arvin K L; Holtzman D M; Linden D J; Zhuo M; Muglia L J; Chatila T A
Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6459-72.
-
2000: Fagan A M; Younkin L H; Morris J C; Fryer J D; Cole T G; Younkin S G; Holtzman D M
Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.
Annals of neurology 2000;48(2):201-10.
-
2000: Fagan A M; Holtzman D M
Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo.
Microscopy research and technique 2000;50(4):297-304.
-
2000: Mulkern R V; Zengingonul H P; Robertson R L; Bogner P; Zou K H; Gudbjartsson H; Guttmann C R; Holtzman D; Kyriakos W; Jolesz F A; Maier S E
Multi-component apparent diffusion coefficients in human brain: relationship to spin-lattice relaxation.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(2):292-300.
-
2000: Han B H; Holtzman D M
BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(15):5775-81.
-
2000: Lendon C L; Han B H; Salimi K; Fagan A M; Behrens M I; Muller M C; Holtzman D M
No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo.
The European journal of neuroscience 2000;12(7):2235-42.
-
2000: Zlokovic B V; Yamada S; Holtzman D; Ghiso J; Frangione B
Clearance of amyloid beta-peptide from brain: transport or metabolism?
Nature medicine 2000;6(7):718-9.
-
2000: Holtzman D M; Fagan A M; Mackey B; Tenkova T; Sartorius L; Paul S M; Bales K; Ashe K H; Irizarry M C; Hyman B T
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.
Annals of neurology 2000;47(6):739-47.
-
2000: Bales K R; Du Y; Holtzman D; Cordell B; Paul S M
Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.
Neurobiology of aging 2000;21(3):427-32; discussion 451-3.
-
2000: Ladu M J; Reardon C; Van Eldik L; Fagan A M; Bu G; Holtzman D; Getz G S
Lipoproteins in the central nervous system.
Annals of the New York Academy of Sciences 2000;903():167-75.
-
2000: Holtzman D M; Bales K R; Tenkova T; Fagan A M; Parsadanian M; Sartorius L J; Mackey B; Olney J; McKeel D; Wozniak D; Paul S M
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2892-7.
-
2000: Han B H; D'Costa A; Back S A; Parsadanian M; Patel S; Shah A R; Gidday J M; Srinivasan A; Deshmukh M; Holtzman D M
BDNF blocks caspase-3 activation in neonatal hypoxia-ischemia.
Neurobiology of disease 2000;7(1):38-53.
-
2000: Zhuo M; Holtzman D M; Li Y; Osaka H; DeMaro J; Jacquin M; Bu G
Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(2):542-9.
-
1999: Holtzman D; Khait I; Mulkern R; Allred E; Rand T; Jensen F; Kraft R
In vivo development of brain phosphocreatine in normal and creatine-treated rabbit pups.
Journal of neurochemistry 1999;73(6):2477-84.
-
1999: Fagan A M; Holtzman D M; Munson G; Mathur T; Schneider D; Chang L K; Getz G S; Reardon C A; Lukens J; Shah J A; LaDu M J
Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice.
The Journal of biological chemistry 1999;274(42):30001-7.
-
1999: Selznick L A; Holtzman D M; Han B H; Gökden M; Srinivasan A N; Johnson E M; Roth K A
In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(9):1020-6.
-
1999: Dugan L L; Kim J S; Zhang Y; Bart R D; Sun Y; Holtzman D M; Gutmann D H
Differential effects of cAMP in neurons and astrocytes. Role of B-raf.
The Journal of biological chemistry 1999;274(36):25842-8.
-
1999: Kowalewski T; Holtzman D M
In situ atomic force microscopy study of Alzheimer's beta-amyloid peptide on different substrates: new insights into mechanism of beta-sheet formation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(7):3688-93.
-
1999: Holtzman D M; Bales K R; Wu S; Bhat P; Parsadanian M; Fagan A M; Chang L K; Sun Y; Paul S M
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.
The Journal of clinical investigation 1999;103(6):R15-R21.
-
1999: Gidday J M; Shah A R; Maceren R G; Wang Q; Pelligrino D A; Holtzman D M; Park T S
Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(3):331-40.
-
1999: Mulkern R V; Gudbjartsson H; Westin C F; Zengingonul H P; Gartner W; Guttmann C R; Robertson R L; Kyriakos W; Schwartz R; Holtzman D; Jolesz F A; Maier S E
Multi-component apparent diffusion coefficients in human brain.
NMR in biomedicine 1999;12(1):51-62.
-
1999: Kekelidze T; Khait I; Togliatti A; Benzycry J; Mulkern R; Holtzman D
Maturational changes in rabbit brain phosphocreatine and creatine kinase.
Annals of the New York Academy of Sciences 1999;893():309-13.
-
1998: Holtzman D; Togliatti A; Khait I; Jensen F
Creatine increases survival and suppresses seizures in the hypoxic immature rat.
Pediatric research 1998;44(3):410-4.
-
1998: Holtzman D M; Fagan A M
Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system.
Trends in cardiovascular medicine 1998;8(6):250-5.
-
1998: Fagan A M; Murphy B A; Patel S N; Kilbridge J F; Mobley W C; Bu G; Holtzman D M
Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury.
Experimental neurology 1998;151(2):314-25.
-
1998: Bu G; Sun Y; Schwartz A L; Holtzman D M
Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1998;273(21):13359-65.
-
1998: Cheng Y; Deshmukh M; D'Costa A; Demaro J A; Gidday J M; Shah A; Sun Y; Jacquin M F; Johnson E M; Holtzman D M
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.
The Journal of clinical investigation 1998;101(9):1992-9.
-
1998: LaDu M J; Gilligan S M; Lukens J R; Cabana V G; Reardon C A; Van Eldik L J; Holtzman D M
Nascent astrocyte particles differ from lipoproteins in CSF.
Journal of neurochemistry 1998;70(5):2070-81.
-
1998: Sun Y; Wu S; Bu G; Onifade M K; Patel S N; LaDu M J; Fagan A M; Holtzman D M
Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(9):3261-72.
-
1998: Holtzman D; Mulkern R; Meyers R; Cook C; Allred E; Khait I; Jensen F; Tsuji M; Laussen P
In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures.
Brain research 1998;783(1):19-27.
-
1998: Parsadanian A S; Cheng Y; Keller-Peck C R; Holtzman D M; Snider W D
Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(3):1009-19.
-
1998: Holtzman D; Brown M; O'Gorman E; Allred E; Wallimann T
Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid.
Developmental neuroscience 1998;20(4-5):469-77.
-
1997: Chao H; Bowers J L; Holtzman D; Mulkern R V
RARE imaging of PCr in human forearm muscles.
Journal of magnetic resonance imaging : JMRI 1997;7(6):1048-55.
-
1997: Narita M; Holtzman D M; Schwartz A L; Bu G
Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.
Journal of neurochemistry 1997;69(5):1904-11.
-
1997: Schätzl H M; Laszlo L; Holtzman D M; Tatzelt J; DeArmond S J; Weiner R I; Mobley W C; Prusiner S B
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.
Journal of virology 1997;71(11):8821-31.
-
1997: Fagan A M; Garber M; Barbacid M; Silos-Santiago I; Holtzman D M
A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7644-54.
-
1997: Holtzman D M; Deshmukh M
Caspases: a treatment target for neurodegenerative disease?
Nature medicine 1997;3(9):954-5.
-
1997: Mulkern R V; Chao H; Bowers J L; Holtzman D
Multiecho approaches to spectroscopic imaging of the brain.
Annals of the New York Academy of Sciences 1997;820():97-122.
-
1997: Holtzman D; Meyers R; O'Gorman E; Khait I; Wallimann T; Allred E; Jensen F
In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog.
The American journal of physiology 1997;272(5 Pt 1):C1567-77.
-
1997: Holtzman D; Meyers R; Khait I; Jensen F
Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats.
Epilepsy research 1997;27(1):7-11.
-
1997: Cheng Y; Gidday J M; Yan Q; Shah A R; Holtzman D M
Marked age-dependent neuroprotection by brain-derived neurotrophic factor against neonatal hypoxic-ischemic brain injury.
Annals of neurology 1997;41(4):521-9.
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1997: Dugan L L; Creedon D J; Johnson E M; Holtzman D M
Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4086-91.
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1997: Fagan A M; Suhr S T; Lucidi-Phillipi C A; Peterson D A; Holtzman D M; Gage F H
Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(7):2499-511.
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1997: Farhangrazi Z S; Ying H; Bu G; Dugan L L; Fagan A M; Choi D W; Holtzman D M
High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture.
Neuroreport 1997;8(5):1127-30.
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1997: Chao H; Bowers J L; Holtzman D; Mulkern R V
Multi-echo 31P spectroscopic imaging of ATP: a scan time reduction strategy.
Journal of magnetic resonance imaging : JMRI 1997;7(2):425-33.
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1997: Narita M; Bu G; Holtzman D M; Schwartz A L
The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development.
Journal of neurochemistry 1997;68(2):587-95.
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1996: Nomura F; Naruse H; duPlessis A; Hiramatsu T; Forbess J; Holtzman D; Volpe J J; Jonas R; Tsuji M
Cerebral oxygenation measured by near infrared spectroscopy during cardiopulmonary bypass and deep hypothermic circulatory arrest in piglets.
Pediatric research 1996;40(6):790-6.
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1996: Fagan A M; Bu G; Sun Y; Daugherty A; Holtzman D M
Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1996;271(47):30121-5.
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1996: Holtzman D M; Santucci D; Kilbridge J; Chua-Couzens J; Fontana D J; Daniels S E; Johnson R M; Chen K; Sun Y; Carlson E; Alleva E; Epstein C J; Mobley W C
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):13333-8.
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1996: Yuen E C; Howe C L; Li Y; Holtzman D M; Mobley W C
Nerve growth factor and the neurotrophic factor hypothesis.
Brain & development 1996;18(5):362-8.
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1996: Hiramatsu T; Jonas R A; Miura T; duPlessis A; Tanji M; Forbess J M; Holtzman D
Cerebral metabolic recovery from deep hypothermic circulatory arrest after treatment with arginine and nitro-arginine methyl ester.
The Journal of thoracic and cardiovascular surgery 1996;112(3):698-707.
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1996: Holtzman D M; Lee S; Li Y; Chua-Couzens J; Xia H; Bredt D S; Mobley W C
Expression of neuronal-NOS in developing basal forebrain cholinergic neurons: regulation by NGF.
Neurochemical research 1996;21(7):861-8.
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1996: Neve R L; Valletta J S; Li Y; Ventosa-Michelman M; Holtzman D M; Mobley W C
A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor.
Brain research. Molecular brain research 1996;39(1-2):185-97.
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1996: Ferriero D M; Holtzman D M; Black S M; Sheldon R A
Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury.
Neurobiology of disease 1996;3(1):64-71.
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1996: Tsuji M K; Mulkern R V; Cook C U; Meyers R L; Holtzman D
Relative phosphocreatine and nucleoside triphosphate concentrations in cerebral gray and white matter measured in vivo by 31P nuclear magnetic resonance.
Brain research 1996;707(2):146-54.
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1996: Holtzman D M; Sheldon R A; Jaffe W; Cheng Y; Ferriero D M
Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury.
Annals of neurology 1996;39(1):114-22.
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1996: Kaldis P; Hemmer W; Zanolla E; Holtzman D; Wallimann T
'Hot spots' of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus.
Developmental neuroscience 1996;18(5-6):542-54.
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1996: Holtzman D; Mulkern R; Tsuji M; Cook C; Meyers R
Phosphocreatine and creatine kinase in piglet cerebral gray and white matter in situ.
Developmental neuroscience 1996;18(5-6):535-41.
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1996: Holtzman D
Brain creatine kinases and phosphocreatine: an update.
Developmental neuroscience 1996;18(5-6):522-3.
-
1995: Whittingham T S; Douglas A; Holtzman D
Creatine and nucleoside triphosphates in rat cerebral gray and white matter.
Metabolic brain disease 1995;10(4):347-52.
-
1995: Holtzman D M; Lowenstein D H
Selective inhibition of axon outgrowth by antibodies to NGF in a model of temporal lobe epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(11):7062-70.
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1995: Holtzman D M; Pitas R E; Kilbridge J; Nathan B; Mahley R W; Bu G; Schwartz A L
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9480-4.
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1995: Carroll S L; Schweitzer J B; Holtzman D M; Miller M L; Sclar G M; Milbrandt J
Elements in the 5' flanking sequences of the mouse low-affinity NGF receptor gene direct appropriate CNS, but not PNS, expression in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3342-56.
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1995: Hiramatsu T; Miura T; Forbess J M; Du Plessis A; Aoki M; Nomura F; Holtzman D; Jonas R A
pH strategies and cerebral energetics before and after circulatory arrest.
The Journal of thoracic and cardiovascular surgery 1995;109(5):948-57; discussion 957-8.
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1995: Tsuji M; Allred E; Jensen F; Holtzman D
Phosphocreatine and ATP regulation in the hypoxic developing rat brain.
Brain research. Developmental brain research 1995;85(2):192-200.
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1995: Li Y; Holtzman D M; Kromer L F; Kaplan D R; Chua-Couzens J; Clary D O; Knüsel B; Mobley W C
Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):2888-905.
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1995: Tsuji M; Naruse H; Volpe J; Holtzman D
Reduction of cytochrome aa3 measured by near-infrared spectroscopy predicts cerebral energy loss in hypoxic piglets.
Pediatric research 1995;37(3):253-9.
-
1995: Holtzman D M; Kilbridge J; Li Y; Cunningham E T; Lenn N J; Clary D O; Reichardt L F; Mobley W C
TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(2):1567-76.
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1995: Holtzman D M; Kilbridge J; Chen K S; Rabin J; Luche R; Carlson E; Epstein C J; Mobley W C
Preliminary characterization of the central nervous system in partial trisomy 16 mice.
Progress in clinical and biological research 1995;393():227-40.
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1994: Holtzman D M; Kilbridge J; Bredt D S; Black S M; Li Y; Clary D O; Reichardt L F; Mobley W C
NOS induction by NGF in basal forebrain cholinergic neurones: evidence for regulation of brain NOS by a neurotrophin.
Neurobiology of disease 1994;1(1-2):51-60.
-
1994: Holtzman D M; Mobley W C
Neurotrophic factors and neurologic disease.
The Western journal of medicine 1994;161(3):246-54.
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1994: Aoki M; Jonas R A; Nomura F; Stromski M E; Tsuji M K; Hickey P R; Holtzman D
Effects of cerebroplegic solutions during hypothermic circulatory arrest and short-term recovery.
The Journal of thoracic and cardiovascular surgery 1994;108(2):291-301.
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1994: Chen C K; Kinsman S L; Holtzman D M; Mobley W C; Johnston M V
A reverse transcription-polymerase chain reaction study of p75 nerve growth factor receptor gene expression in developing rat cerebellum.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1994;12(4):255-62.
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1994: Higgins L S; Holtzman D M; Rabin J; Mobley W C; Cordell B
Transgenic mouse brain histopathology resembles early Alzheimer's disease.
Annals of neurology 1994;35(5):598-607.
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1994: Zhou J; Holtzman D M; Weiner R I; Mobley W C
Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3824-8.
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1994: Aoki M; Nomura F; Stromski M E; Tsuji M K; Fackler J C; Hickey P R; Holtzman D; Jonas R A
Effects of MK-801 and NBQX on acute recovery of piglet cerebral metabolism after hypothermic circulatory arrest.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(1):156-65.
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1993: Holtzman D M; Li Y; Chen K; Gage F H; Epstein C J; Mobley W C
Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration.
Neurology 1993;43(12):2668-73.
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1993: Kawata H; Fackler J C; Aoki M; Tsuji M K; Sawatari K; Offutt M; Hickey P R; Holtzman D; Jonas R A
Recovery of cerebral blood flow and energy state in piglets after hypothermic circulatory arrest versus recovery after low-flow bypass.
The Journal of thoracic and cardiovascular surgery 1993;106(4):671-85.
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1993: Jensen F; Tsuji M; Offutt M; Firkusny I; Holtzman D
Profound, reversible energy loss in the hypoxic immature rat brain.
Brain research. Developmental brain research 1993;73(1):99-105.
-
1993: Holtzman D; Offutt M; Tsuji M; Neuringer L J; Jacobs D
Creatine kinase-catalyzed reaction rate in the cyanide-poisoned mouse brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):153-61.
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1993: Holtzman D; Tsuji M; Wallimann T; Hemmer W
Functional maturation of creatine kinase in rat brain.
Developmental neuroscience 1993;15(3-5):261-70.
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1992: Gasset M; Baldwin M A; Lloyd D H; Gabriel J M; Holtzman D M; Cohen F; Fletterick R; Prusiner S B
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10940-4.
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1992: Holtzman D M; Li Y; Parada L F; Kinsman S; Chen C K; Valletta J S; Zhou J; Long J B; Mobley W C
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF.
Neuron 1992;9(3):465-78.
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1992: Holtzman D M; Li Y W; DeArmond S J; McKinley M P; Gage F H; Epstein C J; Mobley W C
Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1383-7.
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1992: Holtzman D M; Bayney R M; Li Y W; Khosrovi H; Berger C N; Epstein C J; Mobley W C
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.
The EMBO journal 1992;11(2):619-27.
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1992: Holtzman D M; Epstein C J
The molecular genetics of Down syndrome.
Molecular genetic medicine 1992;2():105-20.
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1992: Bredesen D E; Kane D J; Holtzman D M; Epstein C J
Preliminary characterization of long-term reaggregating cultures of trisomy 16 central nervous system.
Progress in clinical and biological research 1992;379():259-70.
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1992: Holtzman D M; Li Y; Gage F H; Epstein C J; Mobley W C
Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome.
Progress in clinical and biological research 1992;379():227-44.
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1991: Jensen F E; Applegate C D; Holtzman D; Belin T R; Burchfiel J L
Epileptogenic effect of hypoxia in the immature rodent brain.
Annals of neurology 1991;29(6):629-37.
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1991: Holtzman D M; Mobley W C
Molecular studies in Alzheimer's disease.
Trends in biochemical sciences 1991;16(4):140-4.
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1991: Holtzman D; McFarland E W; Jacobs D; Offutt M C; Neuringer L J
Maturational increase in mouse brain creatine kinase reaction rates shown by phosphorus magnetic resonance.
Brain research. Developmental brain research 1991;58(2):181-8.
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1991: Holtzman D M; Li Y W; Gage F H; DeArmond S J; Epstein C J; McKinley M P; Mobley W C
Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease.
Progress in clinical and biological research 1991;373():189-202.
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1990: Koliatsos V E; Nauta H J; Clatterbuck R E; Holtzman D M; Mobley W C; Price D L
Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(12):3801-13.
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1989: Holtzman D M; Davis R E; Greco C M
Lumbosacral plexopathy secondary to perirectal abscess in a patient with HIV infection.
Neurology 1989;39(10):1400-1.
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1989: Holtzman D M; Kaku D A; So Y T
New-onset seizures associated with human immunodeficiency virus infection: causation and clinical features in 100 cases.
The American journal of medicine 1989;87(2):173-7.
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1989: Holtzman D; McFarland E; Moerland T; Koutcher J; Kushmerick M J; Neuringer L J
Brain creatine phosphate and creatine kinase in mice fed an analogue of creatine.
Brain research 1989;483(1):68-77.
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1989: Kreisman N R; Olson J E; Horne D S; Holtzman D
Cerebral oxygenation and blood flow in infant and young adult rats.
The American journal of physiology 1989;256(1 Pt 2):R78-85.
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1988: So Y T; Holtzman D M; Abrams D I; Olney R K
Peripheral neuropathy associated with acquired immunodeficiency syndrome. Prevalence and clinical features from a population-based survey.
Archives of neurology 1988;45(9):945-8.
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1987: Holtzman D; Olson J E; DeVries C; Bensch K
Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons.
Toxicology and applied pharmacology 1987;89(2):211-25.
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1987: Holtzman D; Olson J E; Nguyen H; Hsu J; Lewiston N
Brain cellular and mitochondrial respiration in media of altered pH.
Metabolic brain disease 1987;2(2):127-37.
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1986: Fluharty A L; Neidengard L; Holtzman D; Kihara H
Late-onset Krabbe disease initially diagnosed as cerebroside sulfatase activator deficiency.
Metabolic brain disease 1986;1(3):187-95.
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1986: Olson J E; Sankar R; Holtzman D; James A; Fleischhacker D
Energy-dependent volume regulation in primary cultured cerebral astrocytes.
Journal of cellular physiology 1986;128(2):209-15.
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1985: Olson J E; Horne D S; Holtzman D; Miller M
Hyperthermia-induced seizures in rat pups with preexisting ischemic brain injury.
Epilepsia 1985;26(4):360-4.
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1984: Jameson N; Olson J; Nguyen H; Holtzman D
Respiration in primary cultured cerebellar granule neurons and cerebral cortical neurons.
Journal of neurochemistry 1984;42(2):470-4.
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1984: Holtzman D; DeVries C; Nguyen H; Olson J; Bensch K
Maturation of resistance to lead encephalopathy: cellular and subcellular mechanisms.
Neurotoxicology 1984;5(3):97-124.
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1982: Holtzman D; De Vries C; Nguyen H; Jameson N; Olson J; Carrithers M; Bensch K
Development of resistance to lead encephalopathy during maturation in the rat pup.
Journal of neuropathology and experimental neurology 1982;41(6):652-63.
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1982: Holtzman D; Olson J; Nguyen H
Rat cerebral cortical slice respiration in media of various osmolarities.
Brain research 1982;249(2):387-9.
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1982: Holtzman D; Nguyen H; Zamvil S; Olson J
In vitro cellular respiration at elevated temperatures in developing rat cerebral cortex.
Brain research 1982;256(4):401-5.
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1982: Olson J; Holtzman D
Respiration and cell volume of primary cultured cerebral astrocytes in media of various osmolarities.
Brain research 1982;246(2):273-9.
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1982: Holtzman D; Olson J; Zamvil S; Nguyen H
Maturation of potassium-stimulated respiration in rat cerebral cortical slices.
Journal of neurochemistry 1982;39(1):274-6.
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1982: Nguyen H T; Olson J; DeVries C; Savage W; Holtzman D
Scanning electron microscopic study of lead effects on cerebral astrocytes in primary culture.
Scanning electron microscopy 1982;(Pt 2):891-6.
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1981: Olson J E; Holtzman D
Factors influencing the growth and respiration of rat cerebral astrocytes in primary culture.
Neurochemical research 1981;6(12):1337-43.
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1981: Holtzman D; Obana K; Olson J
Hyperthermia-induced seizures in the rat pup: a model for febrile convulsions in children.
Science (New York, N.Y.) 1981;213(4511):1034-6.
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1981: Holtzman D; Hsu J S; Desautel M
Absence of effects of lead feedings and growth-retardation on mitochondrial and microsomal cytochromes in the developing brain.
Toxicology and applied pharmacology 1981;58(1):48-56.
-
1980: Holtzman D; Desautel M
Microsomal cytochromes in the immature and adult rat brain.
Journal of neurochemistry 1980;34(6):1535-7.
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1980: Holtzman D; Obana K; Olson J
Ruthenium Red inhibition of in vitro lead effects on brain mitochondrial respiration.
Journal of neurochemistry 1980;34(6):1776-8.
-
1980: Olson J E; Holtzman D
Respiration in rat cerebral astrocytes from primary culture.
Journal of neuroscience research 1980;5(6):497-506.
-
1978: Holtzman D; Hsu J S; Mortell P
The pathogenesis of lead encephalopathy in the rat pup: effects of maternal PbCO3 feedings from birth.
Pediatric research 1978;12(11):1077-82.
-
1978: Holtzman D; Lewiston N; Herman M M; Desautel M; Brewer E; Robin E
Effects of osmolar changes on isolated mitochondria of brain and liver.
Journal of neurochemistry 1978;30(6):1409-19.
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1978: Holtzman D; Shen Hsu J; Mortell P
In vitro effects of inorganic lead on isolated rat brain mitochondrial respiration.
Neurochemical research 1978;3(2):195-206.
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1977: Holtzman D; Magruder C S
Effects of oligomycin on respiration in developing rat brain mitochondria.
Brain research 1977;120(2):373-8.
-
1977: Holtzman D; Moore C L
Effects of triiodothyronine on oxidative phosphorylation in immature rat brain mitochondria.
Neurology 1977;27(1):90-5.
-
1976: Holtzman D; Hsu J S
Early effects of inorganic lead on immature rat brain mitochondrial respiration.
Pediatric research 1976;10(1):70-5.
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