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Antonín Holý

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Eliška Procházková; Anna Březinová; Lucie Cechová; Antonín Holý; Petr Jansa; Helena Mertlíková-Kaiserová; Martin Dračínský
Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening.
Raquel B Gómez-Coca; Antonín Holý; Bert P Operschall; Astrid Sigel; Claudia A Blindauer; Helmut Sigel
Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Zina Korvasová; Kamil Kovařčík; Pavel Kulich; Miroslav Ledvina; Josef Mašek; Ján Matiašovic; Andrew D Miller; Eliška Bartheldyová; Lukáš Drašar; Antonín Holý; Štěpán Koudelka; Michaela Škrabalová; Pavlína Turánek Knotigová; Jaroslav Turánek
Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: in vitro study on MDBK cell and BHV-1 virus.

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2012: Eliška Procházková; Anna Březinová; Lucie Cechová; Antonín Holý; Petr Jansa; Helena Mertlíková-Kaiserová; Martin Dračínský
Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening.
Bioorganic & medicinal chemistry letters 2012;22(20):6405-9.
2012: Raquel B Gómez-Coca; Antonín Holý; Bert P Operschall; Astrid Sigel; Claudia A Blindauer; Helmut Sigel
Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Chemistry & biodiversity 2012;9(9):2008-34.
2012: Zina Korvasová; Kamil Kovařčík; Pavel Kulich; Miroslav Ledvina; Josef Mašek; Ján Matiašovic; Andrew D Miller; Eliška Bartheldyová; Lukáš Drašar; Antonín Holý; Štěpán Koudelka; Michaela Škrabalová; Pavlína Turánek Knotigová; Jaroslav Turánek
Antiviral effect of HPMPC (Cidofovir®), entrapped in cationic liposomes: in vitro study on MDBK cell and BHV-1 virus.
Journal of controlled release : official journal of the Controlled Release Society 2012;160(2):330-8.
2012: Jiří Blažek; Martin Drančínský; Antonín Holý; Petr Jansa; Martin Maxmilian Kaiser; Marcela Krečmerová; Miroslav Otmar; Ondřej Baszczyňski; Blanka Králová
An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli.
Bioorganic & medicinal chemistry 2012;20(9):3111-8.
2012: Marcela Krečmerová; Martin Dračínský; Dana Hocková; Antonín Holý; Dianne T Keough; Luke W Guddat
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
Bioorganic & medicinal chemistry 2012;20(3):1222-30.
2012: Petra Kostecká; Zdeněk Zídek; Hassan Farghali; Antonín Holý; Eva Kmoníčková
Differential effects of acyclic nucleoside phosphonates on nitric oxide and cytokines in rat hepatocytes and macrophages.
International immunopharmacology 2012;12(2):342-9.
2012: Michal Cesnek; John de Jersey; Ondřej Baszczyňski; Martin Dračínský; Dana Hocková; Antonín Holý; Dianne T Keough; Luke W Guddat
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Bioorganic & medicinal chemistry 2012;20(2):1076-89.
2011: Katerina Vávrová; Robert Cáp; Antonín Holý; Petra Kovaříková; Martina Líbalová; Jaroslav Roh; Barbora Skolová; Alexandr Hrabálek
Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP.
Pharmaceutical research 2011;28(12):3105-15.
2011: J Spak; Vlastimila Spaková; Ivan Votruba; Antonín Holý; Daniela Pavingerová; K Petrzik
Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants.
Antiviral research 2011;92(2):378-81.
2011: Petr Jansa; Richard Mackman; George Stepan; Ivan Votruba; Zdeněk Zídek; Gina Bahador; Ondřej Baszczyňski; Tomas Cihlar; Martin Dračínský; Antonín Holý; Zlatko Janeba
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
European journal of medicinal chemistry 2011;46(9):3748-54.
2011: Dana Hocková; Antonín Holý; Robert Snoeck; Graciela Andrei; Jan Balzarini
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
Bioorganic & medicinal chemistry 2011;19(15):4445-53.
2011: Helena Mertlíková-Kaiserová; Michaela Rumlová; Eva Tloušťová; Eliška Procházková; Antonín Holý; Ivan Votruba
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Biochemical pharmacology 2011;82(2):131-8.
2011: Tomáš Tichý; Graciela Andrei; Martin Dračínský; Antonín Holý; Jan Balzarini; Robert Snoeck; Marcela Krečmerová
New prodrugs of Adefovir and Cidofovir.
Bioorganic & medicinal chemistry 2011;19(11):3527-39.
2011: Ondřej Baszczyňski; Petr Jansa; Martin Dračínský; Blanka Klepetářová; Antonín Holý; Ivan Votruba; Erik de Clercq; Jan Balzarini; Zlatko Janeba
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Bioorganic & medicinal chemistry 2011;19(7):2114-24.
2011: Jaroslav Fulneček; Roman Matyášek; Ivan Votruba; Antonín Holý; Kateřina Křížová; Aleš Kovařík
Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco.
Molecular genetics and genomics : MGG 2011;285(3):225-36.
2011: John de Jersey; Dana Hocková; Antonín Holý; Dianne T Keough; Lieve Naesens; Luke W Guddat
6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.
Current topics in medicinal chemistry 2011;11(16):2085-102.
2010: Marcela Krecmerová; Antonín Holý; Graciela Andrei; Karel Pomeisl; Tomás Tichý; Petra Brehová; Milena Masojídková; Martin Dracínský; Radek Pohl; Genevieve Laflamme; Lieve Naesens; Hon Hui; Tomas Cihlar; Johan Neyts; Erik De Clercq; Jan Balzarini; Robert Snoeck
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
Journal of medicinal chemistry 2010;53(19):6825-37.
2010: Dianne T Keough; Dana Hocková; Marcela Krecmerová; Michal Cesnek; Antonín Holý; Lieve Naesens; Ian M Brereton; Donald J Winzor; John de Jersey; Luke W Guddat
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.
Molecular and biochemical parasitology 2010;173(2):165-9.
2010: Miroslav Hájek; Viktor Cvilink; Ivan Votruba; Antonín Holý; Helena Mertlíková-Kaiserová
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
European journal of pharmacology 2010;643(1):6-12.
2010: Michal Sála; Armando M De Palma; Hubert Hrebabecký; Radim Nencka; Martin Dracínský; Pieter Leyssen; Johan Neyts; Antonín Holý
Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.
Bioorganic & medicinal chemistry 2010;18(12):4374-84.
2010: Marcela Krecmerová; Milena Masojídková; Antonín Holý
Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position.
Bioorganic & medicinal chemistry 2010;18(1):387-95.
2009: Dana Hocková; Antonín Holý; Milena Masojídková; Dianne T Keough; John de Jersey; Luke W Guddat
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorganic & medicinal chemistry 2009;17(17):6218-32.
2009: Jan Konvalinka; Helena Illnerová; Pavel Hobza; Václav Horejsí; Antonín Holý; Pavel Jungwirth; Václav Paces; Pavel Martásek; Jirí Zlatuska
Czech bibliometric system fosters mediocre research.
Nature 2009;460(7259):1079.
2009: Dianne T Keough; Dana Hocková; Antonín Holý; Lieve M J Naesens; Tina S Skinner-Adams; John de Jersey; Luke W Guddat
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
Journal of medicinal chemistry 2009;52(14):4391-9.
2009: Veronika Solínová; Václav Kasicka; Petra Sázelová; Antonín Holý
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.
Electrophoresis 2009;30(12):2245-54.
2009: Petra Doláková; Martin Dracínský; Milena Masojídková; Veronika Solínová; Václav Kasicka; Antonín Holý
Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
European journal of medicinal chemistry 2009;44(6):2408-24.
2008: Marleen Renders; Roel Lievrouw; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic polymerization of phosphonate nucleosides.
Chembiochem : a European journal of chemical biology 2008;9(17):2883-8.
2008: Katerina Vávrová; Katerina Lorencová; Jakub Novotný; Antonín Holý; Alexandr Hrabálek
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(3):901-7.
2008: Lieve Naesens; Graciela Andrei; Ivan Votruba; Marcela Krecmerová; Antonín Holý; Johan Neyts; Erik De Clercq; Robert Snoeck
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
2008: Martin Dracínský; Marcela Krecmerová; Antonín Holý
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy.
Bioorganic & medicinal chemistry 2008;16(14):6778-82.
2008: Karel Pomeisl; Antonín Holý; Ivan Votruba; Radek Pohl
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2008;18(4):1364-7.
2008: Miroslav Hájek; Ivan Votruba; Antonín Holý; Marcela Krecmerová; Eva Tloust'ová
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.
Biochemical pharmacology 2008;75(4):965-72.
2008: Michal Cesnek; Antonín Holý; Milena Masojídková; Eva Kmonícková; Zdenek Zídek
Synthesis of guanidino analogues of PMPDAP and their immunobiological activity.
Bioorganic & medicinal chemistry 2008;16(2):965-80.
2008: Eva Anzenbacherová; Pavel Anzenbacher; Zdenek Zídek; E Buchar; E Kmonícková; P Potmesil; Jana Nekvindová; Alena Veinlichová; Antonín Holý
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Physiological research / Academia Scientiarum Bohemoslovaca 2008;57(5):761-7.
2007: Radim Nencka; Ivan Votruba; Hubert Hrebabecký; Petr Jansa; Eva Tloust'ová; Kveta Horská; Milena Masojídková; Antonín Holý
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.
Journal of medicinal chemistry 2007;50(24):6016-23.
2007: Zdenek Zídek; Eva Kmonícková; Antonín Holý
Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates.
European journal of pharmacology 2007;574(1):77-84.
2007: Marcela Krecmerová; Antonín Holý; Radek Pohl; Milena Masojídková; Graciela Andrei; Lieve Naesens; Johan Neyts; Jan Balzarini; Erik De Clercq; Robert Snoeck
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Journal of medicinal chemistry 2007;50(23):5765-72.
2007: Eva Kmonícková; Petra Melkusová; Hassan Farghali; Antonín Holý; Zdenek Zídek
Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;17(3-4):160-9.
2007: Marcela Krecmerová; Antonín Holý; Alois Pískala; Milena Masojídková; Graciela Andrei; Lieve Naesens; Johan Neyts; Jan Balzarini; Erik De Clercq; Robert Snoeck
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Journal of medicinal chemistry 2007;50(5):1069-77.
2007: Beata Wielgus-Kutrowska; Jan M Antosiewicz; M Długosz; Antonín Holý; Agnieszka Bzowska
Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.
Biophysical chemistry 2007;125(2-3):260-8.
2007: Karel Pomeisl; Ivan Votruba; Antonín Holý; Radek Pohl
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1025-8.
2007: M Zápotocký; J Hanzalová; J Starková; Ivan Votruba; Antonín Holý; Berta Otová
Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance.
Folia biologica 2007;53(3):79-84.
2007: Marleen Renders; Gert Emmerechts; Jef Rozenski; Marcela Krecmerová; Antonín Holý; Piet Herdewijn
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.
Angewandte Chemie (International ed. in English) 2007;46(14):2501-4.
2007: Jan Balzarini; Dominique Schols; Kristel Van Laethem; Erik De Clercq; Dana Hocková; Milina Masojidkova; Antonín Holý
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
The Journal of antimicrobial chemotherapy 2007;59(1):80-6.
2007: Petr Potmesil; Antonín Holý; Eva Kmonícková; Jana Krízková; Zdenek Zídek
Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3.
Journal of biomedical science 2007;14(1):59-66.
2006: Jana Nekvindová; V Masek; Alena Veinlichová; Eva Anzenbacherová; Pavel Anzenbacher; Zdenek Zídek; Antonín Holý
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(12):1165-77.
2006: Jaroslav Matal; Jirí Orság; Jana Nekvindová; Eva Anzenbacherová; Alena Veinlichová; Pavel Anzenbacher; Zdenek Zídek; Antonín Holý
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Neuro endocrinology letters 2006;27 Suppl 2():27-30.
2006: Katerina Horejsí; Graciela Andrei; Erik De Clercq; Robert Snoeck; Radek Pohl; Antonín Holý
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Bioorganic & medicinal chemistry 2006;14(23):8057-65.
2006: Antonín Holý
Antiviral acyclic nucleoside phosphonates structure activity studies.
Antiviral research 2006;71(2-3):248-53.
2006: Petr Potmesil; Marcela Krecmerová; Eva Kmonícková; Antonín Holý; Zdenek Zídek
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
European journal of pharmacology 2006;540(1-3):191-9.
2006: Zdenek Zídek; Pavel Anzenbacher; Eva Anzenbacherová; Evzen Buchar; Eva Kmonícková; Petr Potmesil; Antonín Holý
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes.
Journal of biomedical science 2006;13(3):295-301.
2006: Markéta Schinkmanová; Ivan Votruba; Antonín Holý
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
Biochemical pharmacology 2006;71(9):1370-6.
2006: Veronika Solínová; Václav Kasicka; Dusan Koval; Michal Cesnek; Antonín Holý
Determination of acid-base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis.
Electrophoresis 2006;27(5-6):1006-19.
2006: Radim Nencka; Ivan Votruba; Hubert Hrebabecký; Eva Tloust'ová; Kveta Horská; Milena Masojídková; Antonín Holý
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2006;16(5):1335-7.
2006: Koert J Stittelaar; Johan Neyts; Lieve Naesens; Geert van Amerongen; Rob F van Lavieren; Antonín Holý; Erik De Clercq; Hubert G M Niesters; Edwin Fries; Chantal Maas; Paul G H Mulder; Bernard A.M. Van der Zeijst; Albert D M E Osterhaus
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.
Nature 2006;439(7077):745-8.
2006: Eva Kmonícková; Petr Potmesil; Antonín Holý; Zdenek Zídek
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
European journal of pharmacology 2006;530(1-2):179-87.
2005: Eva Kmonícková; Nikolina Canová; Hassan Farghali; Antonín Holý; Zdenek Zídek
Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):321-4.
2005: Zdenek Zídek; Eva Kmonícková; Antonín Holý
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):315-9.
2005: Erik De Clercq; Antonín Holý
Acyclic nucleoside phosphonates: a key class of antiviral drugs.
Nature reviews. Drug discovery 2005;4(11):928-40.
2005: Miroslav Hájek; Nadezda Matulová; Ivan Votruba; Antonín Holý; Eva Tloust'ová
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates.
Biochemical pharmacology 2005;70(6):894-900.
2005: Alfonso Fernández-Botello; Rolf Griesser; Antonín Holý; Virtudes Moreno; Helmut Sigel
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution.
Inorganic chemistry 2005;44(14):5104-17.
2005: Ivan Votruba; Karel Pomeisl; Eva Tloust'ová; Antonín Holý; Berta Otová
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.
Biochemical pharmacology 2005;69(10):1517-21.
2005: Michal Cesnek; Antonín Holý; Milena Masojídková; Zdenek Zídek
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages.
Bioorganic & medicinal chemistry 2005;13(8):2917-26.
2005: Petra Doláková; Antonín Holý; Zdenek Zídek; Milena Masojídková; Eva Kmonícková
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorganic & medicinal chemistry 2005;13(7):2349-54.
2005: Kenneth Alan Jacobson; Michihiro Ohno; Heng T Duong; Soo-Kyung Kim; Susanna Tchilibon; Michal Cesnek; Antonín Holý; Zhan-Guo Gao
A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.
Chemistry & biology 2005;12(2):237-47.
2005: Erik De Clercq; Graciela Andrei; Jan Balzarini; Pieter Leyssen; Lieve Naesens; Johan Neyts; Christophe Pannecouque; Robert Snoeck; Chunxiao Ying; Dana Hocková; Antonín Holý
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2004: Alfonso Fernández-Botello; Antonín Holý; Virtudes Moreno; Helmut Sigel
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine.
Journal of inorganic biochemistry 2004;98(12):2114-24.
2004: Raquel B Gómez-Coca; Larisa E Kapinos; Antonín Holý; Rosario A Vilaplana; Francisco González-Vílchez; Helmut Sigel
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):961-72.
2004: Zdenek Zídek; Eva Kmonícková; Antonín Holý
Involvement of adenosine A1 receptors in upregulation of nitric oxide by acyclic nucleotide analogues.
European journal of pharmacology 2004;501(1-3):79-86.
2004: Jan Balzarini; Christophe Pannecouque; Lieve Naesens; Graciela Andrei; Robert Snoeck; Erik De Clercq; Dana Hocková; Antonín Holý
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: Agnieszka Bzowska; Gertraud Koellner; Beata Wielgus-Kutrowska; Albrecht Stroh; Grzegorz Raszewski; Antonín Holý; Thomas Steiner; Joachim Frank
Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis.
Journal of molecular biology 2004;342(3):1015-32.
2004: Dana Hocková; Antonín Holý; Milena Masojídková; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3197-202.
2004: Miroslav Otmar; Milena Masojídková; Ivan Votruba; Antonín Holý
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3187-95.
2004: Raquel B Gómez-Coca; Antonín Holý; Rosario A Vilaplana; Francisco González-Vílchez; Helmut Sigel
Nickel(II), copper(II) and zinc(II) complexes of 9-[2- (phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-aza derivative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl] adenine (PMEA). Quantification of four isomeric species in aqueous solution.
Bioinorganic chemistry and applications 2004;():331-52.
2003: Petra Doláková; Milena Masojídková; Antonín Holý
Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2145-60.
2003: Sanaa Botros; Samia William; Olfat Hammam; Zdenek Zídek; Antonín Holý
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
Antimicrobial agents and chemotherapy 2003;47(12):3853-8.
2003: Dana Hocková; Antonín Holý; Milena Masojídková; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Journal of medicinal chemistry 2003;46(23):5064-73.
2003: Marie Valeriánová; Berta Otová; Vlasta Bílá; Jitka Hanzalová; Ivan Votruba; Antonín Holý; Tomás Eckschlager; Ondrej Krejcí; Jan Trka
PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.
Anticancer research 2003;23(6C):4933-9.
2003: Zdenek Zídek; Petr Potmesil; Antonín Holý
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Toxicology and applied pharmacology 2003;192(3):246-53.
2003: Zdenek Zídek; Petr Potmesil; Eva Kmoníèková; Antonín Holý
Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines.
European journal of pharmacology 2003;475(1-3):149-59.
2003: Kathy A Keith; Michael J M Hitchcock; William A Lee; Antonín Holý; Earl R Kern
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Antimicrobial agents and chemotherapy 2003;47(7):2193-8.
2003: Gertraud Koellner; Albrecht Stroh; Grzegorz Raszewski; Antonín Holý; Agnieszka Bzowska
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with multisubstrate analogue inhibitor with 2,6-diaminopurine aglycone.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1699-702.
2003: Beata Wielgus-Kutrowska; Joachim Frank; Antonín Holý; Gertraud Koellner; Agnieszka Bzowska
Interactions of trimeric purine nucleoside phosphorylases with ground state analogues--calorimetric and fluorimetric studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1695-8.
2002: Robert Snoeck; Antonín Holý; Christiane Dewolf Peeters; Joost J van den Oord; Erik De Clercq; Graciela Andrei
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.
Antimicrobial agents and chemotherapy 2002;46(11):3356-61.
2002: Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Stefano Aquaro; Carlo Federico Perno; Herman Egberink; Antonín Holý
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2002;46(7):2185-93.
2002: Gabriel Birkus; Miroslav Hájek; Pavel Kramata; Ivan Votruba; Antonín Holý; Berta Otová
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.
Antimicrobial agents and chemotherapy 2002;46(5):1610-3.
2002: Antonín Holý; Ivan Votruba; Milena Masojídková; Graciela Andrei; Robert Snoeck; Lieve Naesens; Erik De Clercq; Jan Balzarini
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
Journal of medicinal chemistry 2002;45(9):1918-29.
2001: Antonín Holý; Berta Otová; Milos Budesínský; D Emerson; M E Wiles
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Journal of medicinal chemistry 2001;44(25):4462-7.
2001: Zdenek Zídek; D Franková; Antonín Holý
Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production.
Antimicrobial agents and chemotherapy 2001;45(12):3381-6.
2001: K Bobkov; Ivan Gut; Václav Mandys; Antonín Holý; Ivan Votruba; Berta Otová
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma.
Anticancer research 2001;21(4A):2725-31.
2001: Larisa E Kapinos; Antonín Holý; J Günter; Helmut Sigel
Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole (=6,9-dimethyl-1,3-dideazapurine). quantification of the steric effect of the 6-amino group on metal ion binding at the N7 site of the adenine residue.
Inorganic chemistry 2001;40(11):2500-8.
2001: Gunnar Kampf; Marc Sven Lüth; Larisa E Kapinos; J Müller; Antonín Holý; Bernhard Lippert; Helmut Sigel
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(9):1899-908.
2001: Z Janeba; Antonín Holý
Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1103-6.
2001: Raquel B Gómez-Coca; Larisa E Kapinos; Antonín Holý; Rosario A Vilaplana; Francisco González-Vílchez; Helmut Sigel
Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9.
Journal of inorganic biochemistry 2001;84(1-2):39-46.
2000: R Krejcová; K Horská; Ivan Votruba; Antonín Holý
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Biochemical pharmacology 2000;60(12):1907-13.
2000: Zdenek Zídek; D Franková; Antonín Holý
Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli.
International journal of immunopharmacology 2000;22(12):1121-9.
2000: Michal Hocek; Antonín Holý; Ivan Votruba; Hana Dvoráková
Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.
Journal of medicinal chemistry 2000;43(9):1817-25.
2000: K Bobková; Berta Otová; I Marinov; Václav Mandys; A Panczak; Ivan Votruba; Antonín Holý
Anticancer effect of PMEDAP--monitoring of apoptosis.
Anticancer research 2000;20(2A):1041-7.
2000: Ales Kovarík; Helena Van Houdt; Antonín Holý; Ann Depicker
Drug-induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing.
FEBS letters 2000;467(1):47-51.
2000: Raquel B Gómez-Coca; Larisa E Kapinos; Antonín Holý; Rosario A Vilaplana; Francisco González-Vílchez; Helmut Sigel
Ternary Copper(II) Complexes in Solution Formed With 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)Ethyl]Adenine (PMEA).
Metal-based drugs 2000;7(6):313-24.
1999: Ivan Votruba; Marcela Krecmerová; Hubert Hrebabecký; Antonín Holý
Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells.
Nucleosides & nucleotides 1999;18(11-12):2551-64.
1999: Gabriel Birkus; Ivan Votruba; Antonín Holý; Berta Otová
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*.
Biochemical pharmacology 1999;58(3):487-92.
1999: Zdenek Zídek; D Franková; Antonín Holý
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
European journal of pharmacology 1999;376(1-2):91-100.
1999: Antonín Holý; J Günter; Hana Dvoráková; Milena Masojídková; Graciela Andrei; Robert Snoeck; Jan Balzarini; Erik De Clercq
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
Journal of medicinal chemistry 1999;42(12):2064-86.
1999: Zdenek Zídek; D Franková; Antonín Holý
Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates.
Nucleosides & nucleotides 1999;18(4-5):959-61.
1999: D Franková; Zdenek Zídek; Evzen Buchar; Z Jiøièka; Antonín Holý
Antiinflammatory effects of phosphonomethoxyethyl analogues of adenine in a model of adjuvant arthritis.
Nucleosides & nucleotides 1999;18(4-5):955-8.
1998: Miloslava Fojtová; Ales Kovarík; Ivan Votruba; Antonín Holý
Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome.
European journal of biochemistry / FEBS 1998;252(3):347-52.
1997: Zdenek Zídek; D Franková; Antonín Holý; Michael Boubelík; P Dráber
Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine.
Biochemical pharmacology 1997;54(8):855-61.
1997: Zdenek Zídek; Antonín Holý; D Franková
Immunomodulatory properties of antiviral acyclic nucleotide analogues: cytokine stimulatory and nitric oxide costimulatory effects.
International journal of immunopharmacology 1997;19(9-10):587-97.
1997: Zdenek Zídek; Antonín Holý; D Franková
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
European journal of pharmacology 1997;331(2-3):245-52.
1997: Berta Otová; A Panczak; Milada Kohoutová; K Blazek; Jana Schramlová; M Sladká; Antonín Holý
Inhibition of acute graft-versus-host disease in (LEW.1W x LEW.1A)F1 rats using 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine.
Transplantation proceedings 1997;29(3):1736-7.
1997: Berta Otová; Zdenek Zídek; Antonín Holý; Ivan Votruba; M Sladká; I Marinov; V Lesková
Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP.
In vivo (Athens, Greece) 1997;11(2):163-7.
1997: Berta Otová; Antonín Holý; Ivan Votruba; M Sladká; Vlasta Bílá; B Mejsnarová; V Lesková
Genotoxicity of purine acyclic nucleotide analogs.
Folia biologica 1997;43(6):225-9.
1996: Antonín Holý; H Dvoráková; J Jindrich; M Masojídková; M Budĕsínský; Jan Balzarini; G Andrei; E De Clercq
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
Journal of medicinal chemistry 1996;39(20):4073-88.
1996: H Dvoráková; M Masojídková; Antonín Holý; Jan Balzarini; G Andrei; R Snoeck; E De Clercq
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents.
Journal of medicinal chemistry 1996;39(17):3263-8.
1996: P Kramata; Ivan Votruba; Berta Otová; Antonín Holý
Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon.
Molecular pharmacology 1996;49(6):1005-11.
1996: Jan Balzarini; Stefano Aquaro; Carlo Federico Perno; Myriam Witvrouw; Antonín Holý; E De Clercq
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Biochemical and biophysical research communications 1996;219(2):337-41.
1995: D Reymen; Lieve Naesens; Jan Balzarini; Antonín Holý; H Dvoráková; E De Clercq
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
Antiviral research 1995;28(4):343-57.
1995: A Zídek; Antonín Holý; D Franková; Berta Otová
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
European journal of pharmacology 1995;286(3):307-10.
1995: T Cihlár; I Rosenberg; Ivan Votruba; Antonín Holý
Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Antimicrobial agents and chemotherapy 1995;39(1):117-24.
1994: Ales Kovarík; B Koukalová; Antonín Holý; M Bezdĕk
Sequence-specific hypomethylation of the tobacco genome induced with dihydroxypropyladenine, ethionine and 5-azacytidine.
FEBS letters 1994;353(3):309-11.
1994: R Stĕtina; Ivan Votruba; Antonín Holý; A Merta
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1994;41(1):61-6.
1994: Berta Otová; Zdenek Zídek; Antonín Holý; Ivan Votruba; D Franková
Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
Folia biologica 1994;40(4):185-92.
1993: R Stĕtina; Ivan Votruba; Antonín Holý; A Merta
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1993;40(6):373-8.
1993: Vladimír Kren; Berta Otová; Daniel Elleder; Milan Elleder; A Panczak; Antonín Holý
Prevention of acute graft-versus-host disease in rats using 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Folia biologica 1993;39(2):78-86.
1993: Vlasta Bílá; Berta Otová; R Jelínek; M Sladká; B Mejsnarová; Antonín Holý; Vladimír Kren
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Folia biologica 1993;39(3):150-61.
1993: Berta Otová; M Sladká; K Blazek; Jana Schramlová; Ivan Votruba; Antonín Holý
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.
Folia biologica 1993;39(3):142-9.
1993: Berta Otová; M Sladká; Ivan Votruba; Antonín Holý; Vladimír Kren
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
Folia biologica 1993;39(3):136-41.
1993: Berta Otová; Drahomíra Krenová; Zdenek Zídek; Antonín Holý; Ivan Votruba; Vladimír Kren
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Folia biologica 1993;39(6):311-4.
1992: A Merta; Ivan Votruba; J Jindrich; Antonín Holý; T Cihlár; I Rosenberg; M Otmar; T Y Herve
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Biochemical pharmacology 1992;44(10):2067-77.
1992: Berta Otová; Ivan Votruba; Antonín Holý
Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect.
Acta virologica 1992;36(3):313-9.
1991: H Hrebabecký; Antonín Holý
Synthesis of 1-(3-azido-2,3-dideoxy-beta-D-allofuranosyl)thymine, 1-(2,3-dideoxy-beta-D-allofuranosyl)thymine, and 1-(2,3-dideoxy-beta-D-erythro-hex-2-enofuranosyl)thymine.
Carbohydrate research 1991;216():179-86.
1991: D F Ewing; Antonín Holý; Ivan Votruba; R W Humble; G Mackenzie; F Hewedi; G Shaw
Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods.
Carbohydrate research 1991;216():109-18.
1991: E De Clercq; Antonín Holý
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.
Antimicrobial agents and chemotherapy 1991;35(4):701-6.
1991: Jan Balzarini; Lieve Naesens; J Slachmuylders; H Niphuis; I Rosenberg; Antonín Holý; H Schellekens; E De Clercq
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.
AIDS (London, England) 1991;5(1):21-8.
1990: Vladimír Vonka; E Anisimová; J Cerný; Antonín Holý; I Rosenberg; Ivan Votruba
Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.
Antiviral research 1990;14(2):117-21.
1990: Antonín Holý; Ivan Votruba; A Merta; J Cerný; J Veselý; J Vlach; K Sedivá; I Rosenberg; M Otmar; H Hrebabecký
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Antiviral research 1990;13(6):295-311.
1990: Ivan Votruba; M Trávnícek; I Rosenberg; M Otmar; A Merta; H Hrebabecký; Antonín Holý
Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues.
Antiviral research 1990;13(6):287-93.
1990: Ivan Votruba; M Hasobe; Antonín Holý; R T Borchardt
2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells.
Biochemical pharmacology 1990;39(10):1573-80.
1990: J Cerný; Ivan Votruba; V Vonka; I Rosenberg; M Otmar; Antonín Holý
Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Antiviral research 1990;13(5):253-64.
1990: A Merta; Ivan Votruba; I Rosenberg; M Otmar; H Hrebabecký; R Bernaerts; Antonín Holý
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Antiviral research 1990;13(5):209-18.
1990: J Veselý; A Merta; Ivan Votruba; I Rosenberg; Antonín Holý
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Neoplasma 1990;37(2):105-10.
1990: A Merta; J Veselý; Ivan Votruba; I Rosenberg; Antonín Holý
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Neoplasma 1990;37(2):111-20.
1989: Lieve Naesens; Jan Balzarini; I Rosenberg; Antonín Holý; E De Clercq
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1989;8(12):1043-7.
1989: E De Clercq; Antonín Holý; I Rosenberg
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
Antimicrobial agents and chemotherapy 1989;33(2):185-91.
1989: Ales Cvekl; K Horská; K Sebesta; I Rosenberg; Antonín Holý
Phosphonate analogues of dinucleotides as substrates for DNA-dependent RNA polymerase from Escherichia coli in primed abortive initiation reaction.
International journal of biological macromolecules 1989;11(1):33-8.
1987: E De Clercq; T Sakuma; M Baba; Rudi Pauwels; Jan Balzarini; I Rosenberg; Antonín Holý
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.
Antiviral research 1987;8(5-6):261-72.
1987: Ivan Votruba; R Bernaerts; T Sakuma; E De Clercq; A Merta; I Rosenberg; Antonín Holý
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.
Molecular pharmacology 1987;32(4):524-9.
1987: Antonín Holý; I Rosenberg
Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA).
Nucleic acids symposium series 1987;(18):33-6.
1987: H Dvoráková; Antonín Holý
Fluorescent analogs of acyclic S-adenosyl-L-homocysteinase inhibitors.
Nucleic acids symposium series 1987;(18):29-32.
1987: Antonín Holý; Ivan Votruba
Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells.
Nucleic acids symposium series 1987;(18):69-72.
1985: Antonín Holý; I Rosenberg; Ivan Votruba; K Sláma
Metabolic phosphorylation and excretion of some nucleoside analogues in insects.
Biological chemistry Hoppe-Seyler 1985;366(4):355-9.
1984: Jon-Sverre Schanche; T Schanche; P M Ueland; Antonín Holý; Ivan Votruba
The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes.
Molecular pharmacology 1984;26(3):553-8.
1983: Ivan Votruba; Antonín Holý; E De Clercq
Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.
Acta virologica 1983;27(3):273-6.
1983: M Dragún; B Rada; Antonín Holý
Transport of antiviral agent 9-(S)-(2,3-dihydroxypropyl) adenine to animal cells.
Acta virologica 1983;27(2):119-29.
1982: M Gresíková; B Rada; Antonín Holý
Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus.
Acta virologica 1982;26(6):521-3.
1980: B Rada; M Dragún; Ivan Votruba; Antonín Holý
Characteristics of the antiviral effect of 9-(S)-(2, 3-dihydroxypropyl)adenine.
Acta virologica 1980;24(6):433-8.
1980: B Rada; Antonín Holý
Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine.
Chemotherapy 1980;26(3):184-90.