Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Antonín Holý

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Concepts & Ideas

Anatomy

Genes & Molecular Sequences

Molecular Structure

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
48
Votruba, Ivan
29
Zídek, Zdenek
20
Otová, Berta
17
Balzarini, Jan
15
De Clercq, Erik
14
Masojídková, Milena
11
Kmonícková, Eva
11
Andrei, Graciela
11
Snoeck, Robert
10
Franková, D
10
Naesens, Lieve
9
Krecmerová, Marcela
8
Sigel, Helmut
7
Hocková, Dana
6
Sladká, M

Sign-in to see all Coauthors

Publications

TOP 3
Hocková Dana; Holý Antonín; Masojídková Milena; Keough Dianne T; de Jersey John; Guddat Luke W
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Konvalinka Jan; Illnerová Helena; Hobza Pavel; Horejsí Václav; Holý Antonín; Jungwirth Pavel; Paces Václav; Martásek Pavel; Zlatuska Jirí
Czech bibliometric system fosters mediocre research.
Keough Dianne T; Hocková Dana; Holý Antonín; Naesens Lieve M J; Skinner-Adams Tina S; Jersey John de; Guddat Luke W
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Antonín Holý (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Hocková Dana; Holý Antonín; Masojídková Milena; Keough Dianne T; de Jersey John; Guddat Luke W
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorganic & medicinal chemistry 2009;17(17):6218-32.
2009: Konvalinka Jan; Illnerová Helena; Hobza Pavel; Horejsí Václav; Holý Antonín; Jungwirth Pavel; Paces Václav; Martásek Pavel; Zlatuska Jirí
Czech bibliometric system fosters mediocre research.
Nature 2009;460(7259):1079.
2009: Keough Dianne T; Hocková Dana; Holý Antonín; Naesens Lieve M J; Skinner-Adams Tina S; Jersey John de; Guddat Luke W
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
Journal of medicinal chemistry 2009;52(14):4391-9.
2009: Solínová Veronika; Kasicka Václav; Sázelová Petra; Holý Antonín
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.
Electrophoresis 2009;30(12):2245-54.
2009: Doláková Petra; Dracínský Martin; Masojídková Milena; Solínová Veronika; Kasicka Václav; Holý Antonín
Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
European journal of medicinal chemistry 2009;44(6):2408-24.
2008: Renders Marleen; Lievrouw Roel; Krecmerová Marcela; Holý Antonin; Herdewijn Piet
Enzymatic polymerization of phosphonate nucleosides.
Chembiochem : a European journal of chemical biology 2008;9(17):2883-8.
2008: Vávrová Katerina; Lorencová Katerina; Novotný Jakub; Holý Antonín; Hrabálek Alexandr
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(3):901-7.
2008: Naesens Lieve; Andrei Graciela; Votruba Ivan; Krecmerová Marcela; Holý Antonín; Neyts Johan; De Clercq Erik; Snoeck Robert
Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine.
Biochemical pharmacology 2008;76(8):997-1005.
2008: Dracínský Martin; Krecmerová Marcela; Holý Antonín
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy.
Bioorganic & medicinal chemistry 2008;16(14):6778-82.
2008: Pomeisl Karel; Holý Antonín; Votruba Ivan; Pohl Radek
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2008;18(4):1364-7.
2008: Hájek Miroslav; Votruba Ivan; Holý Antonín; Krecmerová Marcela; Tloust'ová Eva
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells.
Biochemical pharmacology 2008;75(4):965-72.
2008: Cesnek Michal; Holý Antonín; Masojídková Milena; Kmonícková Eva; Zídek Zdenek
Synthesis of guanidino analogues of PMPDAP and their immunobiological activity.
Bioorganic & medicinal chemistry 2008;16(2):965-80.
2008: Anzenbacherová E; Anzenbacher P; Zídek Z; Buchar E; Kmonícková E; Potmesil P; Nekvindová J; Veinlichová A; Holý A
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Physiological research / Academia Scientiarum Bohemoslovaca 2008;57(5):761-7.
2007: Nencka Radim; Votruba Ivan; Hrebabecký Hubert; Jansa Petr; Tloust'ová Eva; Horská Kveta; Masojídková Milena; Holý Antonín
Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.
Journal of medicinal chemistry 2007;50(24):6016-23.
2007: Krecmerová Marcela; Holý Antonín; Pohl Radek; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
Journal of medicinal chemistry 2007;50(23):5765-72.
2007: Kmonícková Eva; Melkusová Petra; Farghali Hassan; Holý Antonín; Zídek Zdenek
Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2007;17(3-4):160-9.
2007: Zídek Zdenek; Kmonícková Eva; Holý Antonín
Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates.
European journal of pharmacology 2007;574(1):77-84.
2007: Krecmerová Marcela; Holý Antonín; Pískala Alois; Masojídková Milena; Andrei Graciela; Naesens Lieve; Neyts Johan; Balzarini Jan; De Clercq Erik; Snoeck Robert
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
Journal of medicinal chemistry 2007;50(5):1069-77.
2007: Wielgus-Kutrowska B; Antosiewicz J M; Dlugosz M; Holý A; Bzowska A
Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.
Biophysical chemistry 2007;125(2-3):260-8.
2007: Balzarini Jan; Schols Dominique; Van Laethem Kristel; De Clercq Erik; Hocková Dana; Masojidkova Milina; Holý Antonin
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
The Journal of antimicrobial chemotherapy 2007;59(1):80-6.
2007: Potmesil Petr; Holý Antonín; Kmonícková Eva; Krízková Jana; Zídek Zdenek
Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3.
Journal of biomedical science 2007;14(1):59-66.
2007: Pomeisl Karel; Votruba Ivan; Holý Antonín; Pohl Radek
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1025-8.
2007: Zápotocký M; Hanzalová J; Starková J; Votruba I; Holý A; Otová B
Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance.
Folia biologica 2007;53(3):79-84.
2007: Renders Marleen; Emmerechts Gert; Rozenski Jef; Krecmerová Marcela; Holý Antonin; Herdewijn Piet
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.
Angewandte Chemie (International ed. in English) 2007;46(14):2501-4.
2006: Nekvindová J; Masek V; Veinlichová A; Anzenbacherová E; Anzenbacher P; Zídek Z; Holý A
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(12):1165-77.
2006: Matal Jaroslav; Orság Jirí; Nekvindová Jana; Anzenbacherová Eva; Veinlichová Alena; Anzenbacher Pavel; Zídek Zdenek; Holý Antonín
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Neuro endocrinology letters 2006;27 Suppl 2():27-30.
2006: Horejsí Katerina; Andrei Graciela; De Clercq Erik; Snoeck Robert; Pohl Radek; Holý Antonín
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Bioorganic & medicinal chemistry 2006;14(23):8057-65.
2006: Holý Antonín
Antiviral acyclic nucleoside phosphonates structure activity studies.
Antiviral research 2006;71(2-3):248-53.
2006: Potmesil Petr; Krecmerová Marcela; Kmonícková Eva; Holý Antonín; Zídek Zdenek
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
European journal of pharmacology 2006;540(1-3):191-9.
2006: Zídek Zdenek; Anzenbacher Pavel; Anzenbacherová Eva; Buchar Evzen; Kmonícková Eva; Potmesil Petr; Holý Antonín
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes.
Journal of biomedical science 2006;13(3):295-301.
2006: Schinkmanová Markéta; Votruba Ivan; Holý Antonín
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
Biochemical pharmacology 2006;71(9):1370-6.
2006: Solínová Veronika; Kasicka Václav; Koval Dusan; Cesnek Michal; Holý Antonín
Determination of acid-base dissociation constants of amino- and guanidinopurine nucleotide analogs and related compounds by capillary zone electrophoresis.
Electrophoresis 2006;27(5-6):1006-19.
2006: Nencka Radim; Votruba Ivan; Hrebabecký Hubert; Tloust'ová Eva; Horská Kveta; Masojídková Milena; Holý Antonín
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 2006;16(5):1335-7.
2006: Stittelaar Koert J; Neyts Johan; Naesens Lieve; van Amerongen Geert; van Lavieren Rob F; Holý Antonin; De Clercq Erik; Niesters Hubert G M; Fries Edwin; Maas Chantal; Mulder Paul G H; van der Zeijst Ben A M; Osterhaus Albert D M E
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.
Nature 2006;439(7077):745-8.
2006: Kmonícková Eva; Potmesil Petr; Holý Antonín; Zídek Zdenek
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
European journal of pharmacology 2006;530(1-2):179-87.
2005: Kmonícková Eva; Canová Nikolina Kutinová; Farghali Hassan; Holý Antonín; Zídek Zdenek
Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):321-4.
2005: Zídek Zdenek; Kmonícková Eva; Holý Antonín
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):315-9.
2005: De Clercq Erik; Holý Antonín
Acyclic nucleoside phosphonates: a key class of antiviral drugs.
Nature reviews. Drug discovery 2005;4(11):928-40.
2005: Hájek Miroslav; Matulová Nadezda; Votruba Ivan; Holý Antonín; Tloust'ová Eva
Inhibition of human telomerase by diphosphates of acyclic nucleoside phosphonates.
Biochemical pharmacology 2005;70(6):894-900.
2005: Fernández-Botello Alfonso; Griesser Rolf; Holý Antonín; Moreno Virtudes; Sigel Helmut
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution.
Inorganic chemistry 2005;44(14):5104-17.
2005: Votruba Ivan; Pomeisl Karel; Tloust'ová Eva; Holý Antonín; Otová Berta
Inhibition of thymidine phosphorylase (PD-ECGF) from SD-lymphoma by phosphonomethoxyalkyl thymines.
Biochemical pharmacology 2005;69(10):1517-21.
2005: Cesnek Michal; Holý Antonín; Masojídková Milena; Zídek Zdenek
Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages.
Bioorganic & medicinal chemistry 2005;13(8):2917-26.
2005: Doláková Petra; Holý Antonín; Zídek Zdenek; Masojídková Milena; Kmonícková Eva
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives.
Bioorganic & medicinal chemistry 2005;13(7):2349-54.
2005: Jacobson Kenneth A; Ohno Michihiro; Duong Heng T; Kim Soo-Kyung; Tchilibon Susanna; Cesnek Michal; Holý Antonín; Gao Zhan-Guo
A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.
Chemistry & biology 2005;12(2):237-47.
2005: De Clercq Erik; Andrei G; Balzarini J; Leyssen P; Naesens L; Neyts J; Pannecouque C; Snoeck R; Ying C; Hocková D; Holý A
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2004: Fernández-Botello Alfonso; Holý Antonín; Moreno Virtudes; Sigel Helmut
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine.
Journal of inorganic biochemistry 2004;98(12):2114-24.
2004: Gómez-Coca Raquel B; Kapinos Larisa E; Holý Antonín; Vilaplana Rosario A; González-Vílchez Francisco; Sigel Helmut
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):961-72.
2004: Balzarini J; Pannecouque C; Naesens L; Andrei G; Snoeck R; De Clercq E; Hocková D; Holý A
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: Zídek Zdenek; Kmonícková Eva; Holý Antonín
Involvement of adenosine A1 receptors in upregulation of nitric oxide by acyclic nucleotide analogues.
European journal of pharmacology 2004;501(1-3):79-86.
2004: Bzowska Agnieszka; Koellner Gertraud; Wielgus-Kutrowska Beata; Stroh Albrecht; Raszewski Grzegorz; Holý Antonin; Steiner Thomas; Frank Joachim
Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis.
Journal of molecular biology 2004;342(3):1015-32.
2004: Hocková Dana; Holý Antonín; Masojídková Milena; Andrei Graciela; Snoeck Robert; De Clercq Erik; Balzarini Jan
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3197-202.
2004: Otmar Miroslav; Masojídková Milena; Votruba Ivan; Holý Antonín
Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3187-95.
2004: Gómez-Coca Raquel B; Holý Antonín; Vilaplana Rosario A; González-Vílchez Francisco; Sigel Helmut
Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2- (Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl] adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution.
Bioinorganic chemistry and applications 2004;():331-52.
2003: Doláková Petra; Masojídková Milena; Holý Antonín
Synthesis of base substituted 2-hydroxy-3-(purin-9-yl)-propanoic acids and 4-(purin-9-yl)-3-butenoic acids.
Nucleosides, nucleotides & nucleic acids 2003;22(12):2145-60.
2003: Botros Sanaa; William Samia; Hammam Olfat; Zídek Zdenek; Holý Antonín
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
Antimicrobial agents and chemotherapy 2003;47(12):3853-8.
2003: Valeriánová Marie; Otová Berta; Bílá Vlasta; Hanzalová Jitka; Votruba Ivan; Holý Antonín; Eckschlager Tomás; Krejcí Ondrej; Trka Jan
PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.
Anticancer research 2003;23(6C):4933-9.
2003: Hocková Dana; Holý Antonín; Masojídková Milena; Andrei Graciela; Snoeck Robert; De Clercq Erik; Balzarini Jan
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Journal of medicinal chemistry 2003;46(23):5064-73.
2003: Zídek Zdenek; Potmesil Petr; Holý Antonín
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Toxicology and applied pharmacology 2003;192(3):246-53.
2003: Zídek Zdenek; Potmesil Petr; Kmoníèková Eva; Holý Antonín
Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines.
European journal of pharmacology 2003;475(1-3):149-59.
2003: Keith Kathy A; Hitchcock Michael J M; Lee William A; Holý Antonin; Kern Earl R
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Antimicrobial agents and chemotherapy 2003;47(7):2193-8.
2003: Koellner Gertraud; Stroh Albrecht; Raszewski Grzegorz; Holý Antonin; Bzowska Agnieszka
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with multisubstrate analogue inhibitor with 2,6-diaminopurine aglycone.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1699-702.
2003: Wielgus-Kutrowska Beata; Frank Joachim; Holý Antonin; Koellner Gertraud; Bzowska Agnieszka
Interactions of trimeric purine nucleoside phosphorylases with ground state analogues--calorimetric and fluorimetric studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1695-8.
2002: Snoeck R; Holý A; Dewolf-Peeters C; Van Den Oord J; De Clercq E; Andrei G
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.
Antimicrobial agents and chemotherapy 2002;46(11):3356-61.
2002: Balzarini J; Pannecouque C; De Clercq E; Aquaro S; Perno C-F; Egberink H; Holý A
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2002;46(7):2185-93.
2002: Birkus Gabriel; Hájek Miroslav; Kramata Pavel; Votruba Ivan; Holý Antonín; Otová Berta
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.
Antimicrobial agents and chemotherapy 2002;46(5):1610-3.
2002: Holý Antonín; Votruba Ivan; Masojídková Milena; Andrei Graciela; Snoeck Robert; Naesens Lieve; De Clercq Erik; Balzarini Jan
6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity.
Journal of medicinal chemistry 2002;45(9):1918-29.
2001: Holý A; Otová B; Budesínský M; Emerson D; Wiles M E
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Journal of medicinal chemistry 2001;44(25):4462-7.
2001: Zídek Z; Franková D; Holý A
Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production.
Antimicrobial agents and chemotherapy 2001;45(12):3381-6.
2001: Bobkov K; Gut I; Mandys V; Holý A; Votruba I; Otová B
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/cub rat strain bearing T-cell lymphoma.
Anticancer research 2001;21(4A):2725-31.
2001: Kampf G; Lüth M S; Kapinos L E; Müller J; Holý A; Lippert B; Sigel H
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(9):1899-908.
2001: Kapinos L E; Holý A; Günter J; Sigel H
Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole (=6,9-dimethyl-1,3-dideazapurine). quantification of the steric effect of the 6-amino group on metal ion binding at the N7 site of the adenine residue.
Inorganic chemistry 2001;40(11):2500-8.
2001: Janeba Z; Holý A
Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1103-6.
2001: Gómez-Coca R B; Kapinos L E; Holý A; Vilaplana R A; González-Vílchez F; Sigel H
Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9.
Journal of inorganic biochemistry 2001;84(1-2):39-46.
2000: Zídek Z; Franková D; Holý A
Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli.
International journal of immunopharmacology 2000;22(12):1121-9.
2000: Krejcová R; Horská K; Votruba I; Holý A
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Biochemical pharmacology 2000;60(12):1907-13.
2000: Hocek M; Holý A; Votruba I; Dvoráková H
Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids.
Journal of medicinal chemistry 2000;43(9):1817-25.
2000: Bobková K; Otová B; Marinov I; Mandys V; Panczak A; Votruba I; Holý A
Anticancer effect of PMEDAP--monitoring of apoptosis.
Anticancer research 2000;20(2A):1041-7.
2000: Kovarík A; Van Houdt H; Holý A; Depicker A
Drug-induced hypomethylation of a posttranscriptionally silenced transgene locus of tobacco leads to partial release of silencing.
FEBS letters 2000;467(1):47-51.
2000: Gómez-Coca R B; Kapinos L E; Holý A; Vilaplana R A; González-Vílchez F; Sigel H
Ternary Copper(II) Complexes in Solution Formed With 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)Ethyl]Adenine (PMEA).
Metal-based drugs 2000;7(6):313-24.
1999: Votruba I; Krecmerová M; Hrebabecký H; Holý A
Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells.
Nucleosides & nucleotides 1999;18(11-12):2551-64.
1999: Birkus G; Votruba I; Holý A; Otová B
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*.
Biochemical pharmacology 1999;58(3):487-92.
1999: Zídek Z; Franková D; Holý A
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
European journal of pharmacology 1999;376(1-2):91-100.
1999: Holý A; Günter J; Dvoráková H; Masojídková M; Andrei G; Snoeck R; Balzarini J; De Clercq E
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
Journal of medicinal chemistry 1999;42(12):2064-86.
1999: Zídek Z; Franková D; Holý A
Stimulation of cytokine and nitric oxide production by acyclic nucleoside phosphonates.
Nucleosides & nucleotides 1999;18(4-5):959-61.
1999: Franková D; Zídek Z; Buchar E; Jiøièka Z; Holý A
Antiinflammatory effects of phosphonomethoxyethyl analogues of adenine in a model of adjuvant arthritis.
Nucleosides & nucleotides 1999;18(4-5):955-8.
1998: Fojtová M; Kovarík A; Votruba I; Holý A
Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome.
European journal of biochemistry / FEBS 1998;252(3):347-52.
1997: Zídek Z; Franková D; Holý A; Boubelík M; Dráber P
Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine.
Biochemical pharmacology 1997;54(8):855-61.
1997: Zídek Z; Holý A; Franková D
Immunomodulatory properties of antiviral acyclic nucleotide analogues: cytokine stimulatory and nitric oxide costimulatory effects.
International journal of immunopharmacology 1997;19(9-10):587-97.
1997: Zídek Z; Holý A; Franková D
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
European journal of pharmacology 1997;331(2-3):245-52.
1997: Otová B; Panczak A; Kohoutová M; Blazek K; Schramlová J; Sladká M; Holý A
Inhibition of acute graft-versus-host disease in (LEW.1W x LEW.1A)F1 rats using 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine.
Transplantation proceedings 1997;29(3):1736-7.
1997: Otová B; Zídek Z; Holý A; Votruba I; Sladká M; Marinov I; Lesková V
Antitumor activity of novel purine acyclic nucleotide analogs PMEA and PMEDAP.
In vivo (Athens, Greece) 1997;11(2):163-7.
1997: Otová B; Holý A; Votruba I; Sladká M; Bílá V; Mejsnarová B; Lesková V
Genotoxicity of purine acyclic nucleotide analogs.
Folia biologica 1997;43(6):225-9.
1996: Holý A; Dvoráková H; Jindrich J; Masojídková M; Budesínský M; Balzarini J; Andrei G; De Clercq E
Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.
Journal of medicinal chemistry 1996;39(20):4073-88.
1996: Dvoráková H; Masojídková M; Holý A; Balzarini J; Andrei G; Snoeck R; De Clercq E
Synthesis of 2'-aminomethyl derivatives of N-(2-(phosphonomethoxy)ethyl) nucleotide analogues as potential antiviral agents.
Journal of medicinal chemistry 1996;39(17):3263-8.
1996: Kramata P; Votruba I; Otová B; Holý A
Different inhibitory potencies of acyclic phosphonomethoxyalkyl nucleotide analogs toward DNA polymerases alpha, delta and epsilon.
Molecular pharmacology 1996;49(6):1005-11.
1996: Balzarini J; Aquaro S; Perno C F; Witvrouw M; Holý A; De Clercq E
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Biochemical and biophysical research communications 1996;219(2):337-41.
1995: Reymen D; Naesens L; Balzarini J; Holý A; Dvoráková H; De Clercq E
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
Antiviral research 1995;28(4):343-57.
1995: Zídek A; Holý A; Franková D; Otová B
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
European journal of pharmacology 1995;286(3):307-10.
1995: Cihlár T; Rosenberg I; Votruba I; Holý A
Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Antimicrobial agents and chemotherapy 1995;39(1):117-24.
1994: Kovarík A; Koukalová B; Holý A; Bezdek M
Sequence-specific hypomethylation of the tobacco genome induced with dihydroxypropyladenine, ethionine and 5-azacytidine.
FEBS letters 1994;353(3):309-11.
1994: Stetina R; Votruba I; Holý A; Merta A
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1994;41(1):61-6.
1994: Otová B; Zídek Z; Holý A; Votruba I; Franková D
Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
Folia biologica 1994;40(4):185-92.
1993: Stetina R; Votruba I; Holý A; Merta A
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Neoplasma 1993;40(6):373-8.
1993: Kren V; Otová B; Elleder D; Elleder M; Panczak A; Holý A
Prevention of acute graft-versus-host disease in rats using 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Folia biologica 1993;39(2):78-86.
1993: Bílá V; Otová B; Jelínek R; Sladká M; Mejsnarová B; Holý A; Kren V
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Folia biologica 1993;39(3):150-61.
1993: Otová B; Sladká M; Blazek K; Schramlová J; Votruba I; Holý A
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.
Folia biologica 1993;39(3):142-9.
1993: Otová B; Sladká M; Votruba I; Holý A; Kren V
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
Folia biologica 1993;39(3):136-41.
1993: Otová B; Krenová D; Zídek Z; Holý A; Votruba I; Kren V
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Folia biologica 1993;39(6):311-4.
1992: Merta A; Votruba I; Jindrich J; Holý A; Cihlár T; Rosenberg I; Otmar M; Herve T Y
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Biochemical pharmacology 1992;44(10):2067-77.
1992: Otová B; Votruba I; Holý A
Pretreatment of the host cell with 1-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) is sufficient for its antiviral effect.
Acta virologica 1992;36(3):313-9.
1991: Hrebabecký H; Holý A
Synthesis of 1-(3-azido-2,3-dideoxy-beta-D-allofuranosyl)thymine, 1-(2,3-dideoxy-beta-D-allofuranosyl)thymine, and 1-(2,3-dideoxy-beta-D-erythro-hex-2-enofuranosyl)thymine.
Carbohydrate research 1991;216():179-86.
1991: Ewing D F; Holý A; Votruba I; Humble R W; Mackenzie G; Hewedi F; Shaw G
Synthesis of 4- and 5-amino-1-(2-deoxy-D-erythro-pentofuranosyl)imidazole nucleosides by chemical and biotransformation methods.
Carbohydrate research 1991;216():109-18.
1991: De Clercq E; Holý A
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in various models of herpes simplex virus infection in mice.
Antimicrobial agents and chemotherapy 1991;35(4):701-6.
1991: Balzarini J; Naesens L; Slachmuylders J; Niphuis H; Rosenberg I; Holý A; Schellekens H; De Clercq E
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.
AIDS (London, England) 1991;5(1):21-8.
1990: Vonka V; Anisimová E; Cerný J; Holý A; Rosenberg I; Votruba I
Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.
Antiviral research 1990;14(2):117-21.
1990: Holý A; Votruba I; Merta A; Cerný J; Veselý J; Vlach J; Sedivá K; Rosenberg I; Otmar M; Hrebabecký H
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Antiviral research 1990;13(6):295-311.
1990: Votruba I; Trávnícek M; Rosenberg I; Otmar M; Merta A; Hrebabecký H; Holý A
Inhibition of avian myeloblastosis virus reverse transcriptase by diphosphates of acyclic phosphonylmethyl nucleotide analogues.
Antiviral research 1990;13(6):287-93.
1990: Votruba I; Hasobe M; Holý A; Borchardt R T
2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells.
Biochemical pharmacology 1990;39(10):1573-80.
1990: Cerný J; Votruba I; Vonka V; Rosenberg I; Otmar M; Holý A
Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Antiviral research 1990;13(5):253-64.
1990: Merta A; Votruba I; Rosenberg I; Otmar M; Hrebabecký H; Bernaerts R; Holý A
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Antiviral research 1990;13(5):209-18.
1990: Veselý J; Merta A; Votruba I; Rosenberg I; Holý A
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Neoplasma 1990;37(2):105-10.
1990: Merta A; Veselý J; Votruba I; Rosenberg I; Holý A
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Neoplasma 1990;37(2):111-20.
1989: Naesens L; Balzarini J; Rosenberg I; Holý A; De Clercq E
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1989;8(12):1043-7.
1989: De Clercq E; Holý A; Rosenberg I
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
Antimicrobial agents and chemotherapy 1989;33(2):185-91.
1989: Cvekl A; Horská K; Sebesta K; Rosenberg I; Holý A
Phosphonate analogues of dinucleotides as substrates for DNA-dependent RNA polymerase from Escherichia coli in primed abortive initiation reaction.
International journal of biological macromolecules 1989;11(1):33-8.
1987: De Clercq E; Sakuma T; Baba M; Pauwels R; Balzarini J; Rosenberg I; Holý A
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines.
Antiviral research 1987;8(5-6):261-72.
1987: Votruba I; Bernaerts R; Sakuma T; De Clercq E; Merta A; Rosenberg I; Holý A
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.
Molecular pharmacology 1987;32(4):524-9.
1987: Holý A; Rosenberg I
Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA).
Nucleic acids symposium series 1987;(18):33-6.
1987: Dvoráková H; Holý A
Fluorescent analogs of acyclic S-adenosyl-L-homocysteinase inhibitors.
Nucleic acids symposium series 1987;(18):29-32.
1987: Holý A; Votruba I
Facile preparation of purine and pyrimidine 2-deoxy-beta-D-ribonucleosides by biotransformation on encapsulated cells.
Nucleic acids symposium series 1987;(18):69-72.
1985: Holý A; Rosenberg I; Votruba I; Sláma K
Metabolic phosphorylation and excretion of some nucleoside analogues in insects.
Biological chemistry Hoppe-Seyler 1985;366(4):355-9.
1984: Schanche J S; Schanche T; Ueland P M; Holý A; Votruba I
The effect of aliphatic adenine analogues on S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase in intact rat hepatocytes.
Molecular pharmacology 1984;26(3):553-8.
1983: Votruba I; Holý A; De Clercq E
Metabolism of the broad-spectrum antiviral agent, 9-(S)-(2,3-dihydroxypropyl) adenine, in different cell lines.
Acta virologica 1983;27(3):273-6.
1983: Dragún M; Rada B; Holý A
Transport of antiviral agent 9-(S)-(2,3-dihydroxypropyl) adenine to animal cells.
Acta virologica 1983;27(2):119-29.
1982: Gresíková M; Rada B; Holý A
Studies on the effect of 9-(R, S)-(2,3-dihydroxypropyl)adenine on tick-borne encephalitis virus.
Acta virologica 1982;26(6):521-3.
1980: Rada B; Dragún M; Votruba I; Holý A
Characteristics of the antiviral effect of 9-(S)-(2, 3-dihydroxypropyl)adenine.
Acta virologica 1980;24(6):433-8.
1980: Rada B; Holý A
Virus inhibitory effect of combination of 9-(S)-(2,3-dihydroxypropyl) adenine and 6-azauridine.
Chemotherapy 1980;26(3):184-90.

Sign-in to see more