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George Holz

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Anatomy

Chemicals & Drugs

Physiology

Signal Transduction

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Tamara Tsalkova; Virgil L Woods; Oleg G Chepurny; George G Holz; Colin A Leech; Sheng Li; Tong Liu; Fang C Mei; Xiaodong Cheng
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Colin A Leech; Frank Schwede; Guoxin Kang; Oleg G Chepurny; Igor Dzhura; Hans-Gottfried Genieser; George G Holz
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.
Igor Dzhura; Oleg G Chepurny; Colin A Leech; Michael W Roe; Elvira Dzhura; Xin Xu; Youming Lu; Frank Schwede; Hans-G Genieser; Alan V Smrcka; George G Holz
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

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2012: Tamara Tsalkova; Virgil L Woods; Oleg G Chepurny; George G Holz; Colin A Leech; Sheng Li; Tong Liu; Fang C Mei; Xiaodong Cheng
Isoform-specific antagonists of exchange proteins directly activated by cAMP.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(45):18613-8.
2011: Colin A Leech; Frank Schwede; Guoxin Kang; Oleg G Chepurny; Igor Dzhura; Hans-Gottfried Genieser; George G Holz
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.
Progress in biophysics and molecular biology 2011;107(2):236-47.
2011: Igor Dzhura; Oleg G Chepurny; Colin A Leech; Michael W Roe; Elvira Dzhura; Xin Xu; Youming Lu; Frank Schwede; Hans-G Genieser; Alan V Smrcka; George G Holz
Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.
Islets 2011;3(3):121-8.
2010: Igor Dzhura; Oleg G Chepurny; Grant G Kelley; Colin A Leech; Michael W Roe; Elvira Dzhura; Parisa Afshari; Sundeep Malik; Michael J Rindler; Xin Xu; Youming Lu; Alan V Smrcka; George G Holz
Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.
The Journal of physiology 2010;588(Pt 24):4871-89.
2010: Colin A Leech; Igor Dzhura; Oleg G Chepurny; Frank Schwede; Hans-Gottfried Genieser; George G Holz
Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.
Islets 2010;2(2):72-81.
2010: Oleg G Chepurny; Grant G Kelley; Igor Dzhura; Colin A Leech; Michael W Roe; Elvira Dzhura; Xiangquan Li; Frank Schwede; Hans-Gottfried Genieser; George G Holz
PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E622-33.
2010: Colin A Leech; Oleg G Chepurny; George G Holz
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.
Vitamins and hormones 2010;84():279-302.
2009: Grant G Kelley; Oleg G Chepurny; Frank Schwede; Hans-Gottfried Genieser; Colin A Leech; Michael W Roe; Xiangquan Li; Igor Dzhura; Elvira Dzhura; Parisa Afshari; George G Holz
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.
Islets 2009;1(3):260-5.
2009: Oleg G Chepurny; Colin A Leech; Grant G Kelley; Igor Dzhura; Elvira Dzhura; Xiangquan Li; Michael J Rindler; Frank Schwede; Hans-Gottfried Genieser; George G Holz
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.
The Journal of biological chemistry 2009;284(16):10728-36.
2009: Marie-Line Peyot; Joshua P Gray; Julien Lamontagne; Peter J S Smith; George G Holz; S R Murthy Madiraju; Marc Prentki; Emma Heart
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.
PloS one 2009;4(7):e6221.
2008: Violeta Stanojevic; Joel F Habener; George G Holz; Colin A Leech
Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.
Biochemical and biophysical research communications 2008;368(3):614-9.
2008: Guoxin Kang; Colin A Leech; Oleg G Chepurny; William A Coetzee; George G Holz
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells.
The Journal of physiology 2008;586(5):1307-19.
2008: George G Holz; Emma Heart; Colin A Leech
Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach".
American journal of physiology. Cell physiology 2008;294(1):C4-6.
2008: George G Holz; Oleg G Chepurny; Frank Schwede
Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.
Cellular signalling 2008;20(1):10-20.
2007: Oleg G Chepurny; George G Holz
A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts.
Journal of biomolecular screening 2007;12(5):740-6.
2006: George G Holz; Guoxin Kang; Mark Harbeck; Michael W Roe; Oleg G Chepurny
Cell physiology of cAMP sensor Epac.
The Journal of physiology 2006;577(Pt 1):5-15.
2006: Mark Harbeck; Oleg G Chepurny; Viacheslav O Nikolaev; Martin J Lohse; George G Holz; Michael W Roe
Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells.
Science's STKE : signal transduction knowledge environment 2006;2006(353):pl6.
2006: Guoxin Kang; Oleg G Chepurny; Brian Malester; Michael J Rindler; Holger Rehmann; Johannes L Bos; Frank Schwede; William A Coetzee; George G Holz
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.
The Journal of physiology 2006;573(Pt 3):595-609.
2005: Luis R Landa; Mark Harbeck; Kelly Kaihara; Oleg G Chepurny; Kajorn Kitiphongspattana; Oliver Graf; Viacheslav O Nikolaev; Martin J Lohse; George G Holz; Michael W Roe
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line.
The Journal of biological chemistry 2005;280(35):31294-302.
2005: Guoxin Kang; Oleg G Chepurny; Michael J Rindler; Leon Collis; Zina Chepurny; Wen-Hong Li; Mark Harbeck; Michael W Roe; George G Holz
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.
The Journal of physiology 2005;566(Pt 1):173-88.
2005: George G Holz; Oleg G Chepurny
Diabetes outfoxed by GLP-1?
Science's STKE : signal transduction knowledge environment 2005;2005(268):pe2.
2004: George G Holz; G Holz
New insights concerning the glucose-dependent insulin secretagogue action of glucagon-like peptide-1 in pancreatic beta-cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2004;36(11-12):787-94.
2004: George G Holz
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell.
Diabetes 2004;53(1):5-13.
2003: George G Holz; Oleg G Chepurny
Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.
Current medicinal chemistry 2003;10(22):2471-83.
2003: Guoxin Kang; Jamie W Joseph; Oleg G Chepurny; Marie Monaco; Michael B Wheeler; Johannes L Bos; Frank Schwede; Hans-Gottfried Genieser; George G Holz
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.
The Journal of biological chemistry 2003;278(10):8279-85.
2003: Andreea Ianus; George G Holz; Neil Theise; Mehboob A Hussain
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.
The Journal of clinical investigation 2003;111(6):843-50.
2003: Guoxin Kang; George G Holz
Amplification of exocytosis by Ca2+-induced Ca2+ release in INS-1 pancreatic beta cells.
The Journal of physiology 2003;546(Pt 1):175-89.
2002: Oleg G Chepurny; Mehboob A Hussain; George G Holz
Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220.
Endocrinology 2002;143(6):2303-13.
2002: Oleg G Chepurny; George G Holz
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.
Cell and tissue research 2002;307(2):191-201.
2001: Guoxin Kang; Oleg G Chepurny; George G Holz
cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic beta-cells.
The Journal of physiology 2001;536(Pt 2):375-85.
2000: Colin A Leech; George G Holz; Oleg G Chepurny; Joel F Habener
Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.
Biochemical and biophysical research communications 2000;278(1):44-7.
2000: George G Holz; Colin A Leech; Joel F Habener
Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells.
Biochimie 2000;82(9-10):915-26.
1999: George G Holz; Colin A Leech; R Scott Heller; Marie-Hélène Castonguay; Joel F Habener
cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37).
The Journal of biological chemistry 1999;274(20):14147-56.
1999: Jochen Seufert; Timothy J Kieffer; Colin A Leech; George G Holz; W Moritz; Camillo Ricordi; Joel F Habener
Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1999;84(2):670-6.
1998: George G Holz; Joel F Habener
Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1998;121(2):177-84.
1998: George G Holz; T J Turner
Pertussis toxin-sensitive GTP-binding proteins characterized in synaptosomal fractions of embryonic avian cerebral cortex.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1998;119(1):201-11.
1997: Timothy J Kieffer; R Scott Heller; Colin A Leech; George G Holz; Joel F Habener
Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells.
Diabetes 1997;46(6):1087-93.
1996: Colin A Leech; George G Holz; Joel F Habener
Signal transduction of PACAP and GLP-1 in pancreatic beta cells.
Annals of the New York Academy of Sciences 1996;805():81-92; discussion 92-3.
1995: George G Holz; Colin A Leech; Joel F Habener
Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.
The Journal of biological chemistry 1995;270(30):17749-57.
1995: Colin A Leech; George G Holz; Joel F Habener
Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells.
Endocrinology 1995;136(4):1530-6.
1994: Colin A Leech; George G Holz; Joel F Habener
Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells.
Endocrinology 1994;135(1):365-72.
1994: Colin A Leech; George G Holz
Application of patch clamp methods to the study of calcium currents and calcium channels.
Methods in cell biology 1994;40():135-51.
1993: George G Holz; Willem Kuhtreiber; Joel F Habener
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).
Nature 1993;361(6410):362-5.
1992: George G Holz; Joel F Habener
Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept.
Trends in biochemical sciences 1992;17(10):388-93.