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Ulrike Holzgrabe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

Concepts & Ideas

Chemicals & Drugs

Physiology

Allosteric Regulation

Genes & Molecular Sequences

Molecular Structure

Phenomena

Living Beings

Swine

Anatomy

Myocardium

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Co-Publications
Name
24
Mohr, Klaus
17
Tränkle, Christian
11
Kinzig, Martina
10
Sörgel, Fritz
8
Laug, Stefanie
7
Landersdorfer, Cornelia
7
Unger, Matthias
7
Bulitta, Jürgen
6
Bitar, Yaser
6
Drusano, George
6
Hoerr, Verena
6
Kapková, Petra
5
Baumann, Knut
5
Wedig, Maike
5
Muth, Mathias

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Publications

TOP 3
Montoya Guillermo; Arango Gabriel J; Unger Matthias; Holzgrabe Ulrike
O-glycoside sequence of pentacyclic triterpene saponins from Phytolacca bogotensis using HPLC-ESI/multi-stage tandem mass spectrometry.
Bulitta Jürgen B; Duffull Stephen B; Landersdorfer Cornelia B; Kinzig Martina; Holzgrabe Ulrike; Stephan Ulrich; Drusano George L; Sörgel Fritz
Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.
Landersdorfer Cornelia B; Kirkpatrick Carl M J; Kinzig Martina; Bulitta Jürgen B; Holzgrabe Ulrike; Drusano George L; Sörgel Fritz
Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.

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All Publications

2009: Montoya Guillermo; Arango Gabriel J; Unger Matthias; Holzgrabe Ulrike
O-glycoside sequence of pentacyclic triterpene saponins from Phytolacca bogotensis using HPLC-ESI/multi-stage tandem mass spectrometry.
Phytochemical analysis : PCA 2009;20(6):465-74.
2009: Bulitta Jürgen B; Duffull Stephen B; Landersdorfer Cornelia B; Kinzig Martina; Holzgrabe Ulrike; Stephan Ulrich; Drusano George L; Sörgel Fritz
Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.
Diagnostic microbiology and infectious disease 2009;65(2):130-41.
2009: Landersdorfer Cornelia B; Kirkpatrick Carl M J; Kinzig Martina; Bulitta Jürgen B; Holzgrabe Ulrike; Drusano George L; Sörgel Fritz
Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid.
Antimicrobial agents and chemotherapy 2009;53(9):3902-7.
2009: Bulitta J B; Landersdorfer C B; Kinzig M; Holzgrabe U; Sorgel F
New semiphysiological absorption model to assess the pharmacodynamic profile of cefuroxime axetil using nonparametric and parametric population pharmacokinetics.
Antimicrobial agents and chemotherapy 2009;53(8):3462-71.
2009: Niedermeier Sabine; Singethan Katrin; Rohrer Sebastian G; Matz Magnus; Kossner Markus; Diederich Sandra; Maisner Andrea; Schmitz Jens; Hiltensperger Georg; Baumann Knut; Holzgrabe Ulrike; Schneider-Schaulies Jürgen
A small-molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion.
Journal of medicinal chemistry 2009;52(14):4257-65.
2009: Holzgrabe Ulrike
Meropenem-clavulanate: a new strategy for the treatment of tuberculosis?
ChemMedChem 2009;4(7):1051-3.
2009: Waibel Benjamin; Albert Christoph; Holzgrabe Ulrike
Evaluation of the extent of protein binding by means of NMR diffusion and relaxation experiments, and automated continuous ultrafiltration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(3-4):191-7.
2009: Landersdorfer Cornelia B; Kinzig Martina; Bulitta Jürgen B; Hennig Friedrich F; Holzgrabe Ulrike; Sörgel Fritz; Gusinde Johannes
Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation.
Antimicrobial agents and chemotherapy 2009;53(6):2569-78.
2009: Landersdorfer Cornelia B; Kinzig Martina; Hennig Friedrich F; Bulitta Jürgen B; Holzgrabe Ulrike; Drusano George L; Sörgel Fritz; Gusinde Johannes
Penetration of moxifloxacin into bone evaluated by Monte Carlo simulation.
Antimicrobial agents and chemotherapy 2009;53(5):2074-81.
2009: Norwig J; Beyer T; Brinz D; Holzgrabe U; Diller M; Manns D
Prediction of the oversulphated chondroitin sulphate contamination of unfractionated heparin by ATR-IR spectrophotometry.
Pharmeuropa scientific notes 2009;2009(1):17-24.
2009: Diwischek Florian; Morschhäuser Joachim; Holzgrabe Ulrike
Cerulenin analogues as inhibitors of efflux pumps in drug-resistant Candida albicans.
Archiv der Pharmazie 2009;342(3):150-64.
2009: Ghaly Hany; Kriete Christine; Sahin Seher; Pflöger Anja; Holzgrabe Ulrike; Zünkler Bernd Joachim; Rustenbeck Ingo
The insulinotropic effect of fluoroquinolones.
Biochemical pharmacology 2009;77(6):1040-52.
2009: Ponte-Sucre Alicia; Gulder Tanja; Wegehaupt Annemarie; Albert Christoph; Rikanovic Carina; Schaeflein Leonhard; Frank Andreas; Schultheis Martina; Unger Matthias; Holzgrabe Ulrike; Bringmann Gerhard; Moll Heidrun
Structure-activity relationship and studies on the molecular mechanism of leishmanicidal N,C-coupled arylisoquinolinium salts.
Journal of medicinal chemistry 2009;52(3):626-36.
2009: Antony Johannes; Kellershohn Kerstin; Mohr-Andrä Marion; Kebig Anna; Prilla Stefanie; Muth Mathias; Heller Eberhard; Disingrini Teresa; Dallanoce Clelia; Bertoni Simona; Schrobang Jasmin; Tränkle Christian; Kostenis Evi; Christopoulos Arthur; Höltje Hans-Dieter; Barocelli Elisabetta; De Amici Marco; Holzgrabe Ulrike; Mohr Klaus
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):442-50.
2009: Holzgrabe Ulrike
[In Process Citation]
Pharmazie in unserer Zeit 2009;38(6):560-2.
2009: Holzgrabe Ulrike
[In Process Citation]
Pharmazie in unserer Zeit 2009;38(6):487-8.
2009: Holzgrabe Ulrike
[In Process Citation]
Pharmazie in unserer Zeit 2009;38(6):486-7.
2009: Holzgrabe Ulrike; Schlitzer Martin; Stich August
[In Process Citation]
Pharmazie in unserer Zeit 2009;38(6):483.
2009: Landersdorfer Cornelia B; Bulitta Jürgen B; Kinzig Martina; Holzgrabe Ulrike; Sörgel Fritz
Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.
Clinical pharmacokinetics 2009;48(2):89-124.
2009: Holzgrabe Ulrike
[Everything is in flux. Vitamin E]
Pharmazie in unserer Zeit 2009;38(2):132-5.
2009: Holzgrabe Ulrike
[New antibiotics in sight?]
Pharmazie in unserer Zeit 2009;38(2):106-8.
2008: Landersdorfer Cornelia B; Kirkpatrick Carl M J; Kinzig Martina; Bulitta Jürgen B; Holzgrabe Ulrike; Sörgel Fritz
Inhibition of flucloxacillin tubular renal secretion by piperacillin.
British journal of clinical pharmacology 2008;66(5):648-59.
2008: Brinz Daniela; Holzgrabe Ulrike
Analysis of the molecular size distribution of polyethylene glycols by CE-UV versus HPLC with evaporative light scattering detection.
Electrophoresis 2008;29(17):3605-11.
2008: Beyer T; Diehl B; Randel G; Humpfer E; Schäfer H; Spraul M; Schollmayer C; Holzgrabe U
Quality assessment of unfractionated heparin using 1H nuclear magnetic resonance spectroscopy.
Journal of pharmaceutical and biomedical analysis 2008;48(1):13-9.
2008: Borst Claudia; Holzgrabe Ulrike
Enantioseparation of dopa and related compounds by cyclodextrin-modified microemulsion electrokinetic chromatography.
Journal of chromatography. A 2008;1204(2):191-6.
2008: Goebel Tim; Ulmer Daniela; Projahn Holger; Kloeckner Jessica; Heller Eberhard; Glaser Melanie; Ponte-Sucre Alicia; Specht Sabine; Sarite Salem Ramadan; Hoerauf Achim; Kaiser Annette; Hauber Ilona; Hauber Joachim; Holzgrabe Ulrike
In search of novel agents for therapy of tropical diseases and human immunodeficiency virus.
Journal of medicinal chemistry 2008;51(2):238-50.
2008: Holzgrabe Ulrike; Sinz Andrea
[Alpha blockers and 5-alpha reductase inhibitors]
Pharmazie in unserer Zeit 2008;37(4):273.
2008: Holzgrabe Ulrike; Bennack Edith
[5-Alpha reductase inhibitors--benign prostatic hypertrophy and much more]
Pharmazie in unserer Zeit 2008;37(4):310-4.
2008: Holzgrabe Ulrike; Laug Stefanie; Wienen Frank
Micellar electrokinetic chromatography of aminoglycosides.
Methods in molecular biology (Clifton, N.J.) 2008;384():735-49.
2008: Holzgrabe Ulrike; Schubert-Zsilavecz Manfred
[Helping ourselves to promote our scientific advancement]
Pharmazie in unserer Zeit 2008;37(1):97.
2008: Holzgrabe Ulrike
[Statement of accounts]
Pharmazie in unserer Zeit 2008;37(1):94-5.
2007: Jäger Dorothea; Schmalenbach Caroline; Prilla Stefanie; Schrobang Jasmin; Kebig Anna; Sennwitz Matthias; Heller Eberhard; Tränkle Christian; Holzgrabe Ulrike; Höltje Hans-Dieter; Mohr Klaus
Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.
The Journal of biological chemistry 2007;282(48):34968-76.
2007: Hoerr Verena; Ziebuhr Wilma; Kozitskaya Svetlana; Katzowitsch Elena; Holzgrabe Ulrike
Laser-induced fluorescence-capillary electrophoresis and fluorescence microplate reader measurement: two methods to quantify the effect of antibiotics.
Analytical chemistry 2007;79(19):7510-8.
2007: Landersdorfer Cornelia B; Kirkpatrick Carl M J; Kinzig-Schippers Martina; Bulitta Jürgen B; Holzgrabe Ulrike; Drusano George L; Sörgel Fritz
Population pharmacokinetics at two dose levels and pharmacodynamic profiling of flucloxacillin.
Antimicrobial agents and chemotherapy 2007;51(9):3290-7.
2007: Bitar Yaser; Holzgrabe Ulrike
Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography.
Electrophoresis 2007;28(15):2693-700.
2007: Kopec Susanne; Holzgrabe Ulrike
Amino acids: aspects of impurity profiling by means of CE.
Electrophoresis 2007;28(13):2153-67.
2007: Bulitta J B; Duffull S B; Kinzig-Schippers M; Holzgrabe U; Stephan U; Drusano G L; Sörgel F
Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy 2007;51(7):2497-507.
2007: Bitar Yaser; Holzgrabe Ulrike
Impurity profiling of atropine sulfate by microemulsion electrokinetic chromatography.
Journal of pharmaceutical and biomedical analysis 2007;44(3):623-33.
2007: Holzgrabe Ulrike; Muth Mathias
[Chronic obstructive pulmonary disease]
Medizinische Monatsschrift für Pharmazeuten 2007;30(5):168-76; quiz 177-8.
2007: Neugebauer U; Schmid U; Baumann K; Ziebuhr W; Kozitskaya S; Holzgrabe U; Schmitt M; Popp J
The influence of fluoroquinolone drugs on the bacterial growth of S. epidermidis utilizing the unique potential of vibrational spectroscopy.
The journal of physical chemistry. A 2007;111(15):2898-906.
2007: Waibel Benjamin; Holzgrabe Ulrike
1H and 19F NMR relaxation studies of fleroxacin with Micrococcus luteus.
Journal of pharmaceutical and biomedical analysis 2007;43(5):1595-601.
2007: Muth Mathias; Hoerr Verena; Glaser Melanie; Ponte-Sucre Alicia; Moll Heidrun; Stich August; Holzgrabe Ulrike
Antitrypanosomal activity of quaternary naphthalimide derivatives.
Bioorganic & medicinal chemistry letters 2007;17(6):1590-3.
2007: Holzgrabe Ulrike; Kapková Petra; Alptüzün Vildan; Scheiber Josef; Kugelmann Eva
Targeting acetylcholinesterase to treat neurodegeneration.
Expert opinion on therapeutic targets 2007;11(2):161-79.
2007: Deubel A; Holzgrabe U
Development of an enhanced separation of erythromycin and its related substances by liquid chromatography.
Journal of pharmaceutical and biomedical analysis 2007;43(2):493-8.
2007: Holzgrabe Ulrike
[An old drug as a carcinostatic. The new career of thalidomide]
Pharmazie in unserer Zeit 2007;36(6):446-9.
2007: Holzgrabe Ulrike
[Lactivicin--an antibiotic against penicillin-resistant pneumococci]
Pharmazie in unserer Zeit 2007;36(6):421-2.
2007: Holzgrabe Ulrike
[Two flies with one blow--platencin, an new antibiotic]
Pharmazie in unserer Zeit 2007;36(6):418-9.
2007: Bennack Edith; Holzgrabe Ulrike
[H1-antihistaminics of the first generation]
Pharmazie in unserer Zeit 2007;36(3):202-4.
2006: Kopec S; Almeling S; Holzgrabe U
Determination of the impurity profile of adenosine by means of ion-pair reversed-phase chromatography.
Pharmeuropa scientific notes 2006;2006(2):17-21.
2006: Zünkler Bernd J; Claassen Sonja; Wos-Maganga Maria; Rustenbeck Ingo; Holzgrabe Ulrike
Effects of fluoroquinolones on HERG channels and on pancreatic beta-cell ATP-sensitive K+ channels.
Toxicology 2006;228(2-3):239-48.
2006: Deubel A; Fandiño A S; Sörgel F; Holzgrabe U
Determination of erythromycin and related substances in commercial samples using liquid chromatography/ion trap mass spectrometry.
Journal of chromatography. A 2006;1136(1):39-47.
2006: Kaiser A; Ulmer D; Goebel T; Holzgrabe U; Saeftel M; Hoerauf A
Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria.
Mini reviews in medicinal chemistry 2006;6(11):1231-41.
2006: Hoerr Verena; Hoffmann Kerstin; Schollmayer Curd; Holzgrabe Ulrike; Haase Axel; Jakob Peter; Faber Cornelius
Assessment of inhibitory potency of antibiotics by MRI: apparent T2 as a marker of cell growth.
Magma (New York, N.Y.) 2006;19(5):247-55.
2006: Kapková Petra; Heller Eberhard; Kugelmann Eva; Faber Johan; Bringmann Gerhard; Kessler Ulrich; Folkers Gerd; Holzgrabe Ulrike
Random chemistry as a new tool for the generation of small-compound libraries.
Archiv der Pharmazie 2006;339(9):489-97.
2006: Saeftel Michael; Sarite Ramadan Salem; Njuguna Tujo; Holzgrabe Ulrike; Ulmer Daniela; Hoerauf Achim; Kaiser Annette
Piperidones with activity against Plasmodium falciparum.
Parasitology research 2006;99(3):281-6.
2006: Neugebauer U; Schmid U; Baumann K; Holzgrabe U; Ziebuhr W; Kozitskaya S; Kiefer W; Schmitt M; Popp J
Characterization of bacterial growth and the influence of antibiotics by means of UV resonance Raman spectroscopy.
Biopolymers 2006;82(4):306-11.
2006: Holzgrabe Ulrike; Brinz Daniela; Kopec Susanne; Weber Christine; Bitar Yaser
Why not using capillary electrophoresis in drug analysis?
Electrophoresis 2006;27(12):2283-92.
2006: Marini Roland Djang'eing'a; Groom Carl; Doucet François R; Hawari Jalal; Bitar Yaser; Holzgrabe Ulrike; Gotti Roberto; Schappler Julie; Rudaz Serge; Veuthey Jean-Luc; Mol Roelof; Somsen Govert W; de Jong Gerhardus J; Ha Pham Thi Thanh; Zhang Jie; Van Schepdael Ann; Hoogmartens Jos; Briône Willy; Ceccato Attilio; Boulanger Bruno; Mangelings Debby; Vander Heyden Yvan; Van Ael Willy; Jimidar Ilias; Pedrini Matteo; Servais Anne-Catherine; Fillet Marianne; Crommen Jacques; Rozet Eric; Hubert Philippe
Interlaboratory study of a NACE method for the determination of R-timolol content in S-timolol maleate: assessment of uncertainty.
Electrophoresis 2006;27(12):2386-99.
2006: Vicik Radim; Hoerr Verena; Glaser Melanie; Schultheis Martina; Hansell Elizabeth; McKerrow James H; Holzgrabe Ulrike; Caffrey Conor R; Ponte-Sucre Alicia; Moll Heidrun; Stich August; Schirmeister Tanja
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.
Bioorganic & medicinal chemistry letters 2006;16(10):2753-7.
2006: Sürig Ulf; Gaal Klaudia; Kostenis Evi; Tränkle Christian; Mohr Klaus; Holzgrabe Ulrike
Muscarinic allosteric modulators: atypical structure-activity-relationships in bispyridinium-type compounds.
Archiv der Pharmazie 2006;339(4):207-12.
2006: Heinze Andreas; Holzgrabe Ulrike
Determination of the extent of protein binding of antibiotics by means of an automated continuous ultrafiltration method.
International journal of pharmaceutics 2006;311(1-2):108-12.
2006: Disingrini Teresa; Muth Mathias; Dallanoce Clelia; Barocelli Elisabetta; Bertoni Simona; Kellershohn Kerstin; Mohr Klaus; De Amici Marco; Holzgrabe Ulrike
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.
Journal of medicinal chemistry 2006;49(1):366-72.
2006: Grossmüller Maren; Antony Johannes; Tränkle Christian; Holzgrabe Ulrike; Mohr Klaus
Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.
Naunyn-Schmiedeberg's archives of pharmacology 2006;372(4):267-76.
2006: Kapková Petra; Alptüzün Vildan; Frey Peter; Erciyas Ercin; Holzgrabe Ulrike
Search for dual function inhibitors for Alzheimer's disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity.
Bioorganic & medicinal chemistry 2006;14(2):472-8.
2006: Holzgrabe Ulrike; De Amici Marco; Mohr Klaus
Allosteric modulators and selective agonists of muscarinic receptors.
Journal of molecular neuroscience : MN 2006;30(1-2):165-8.
2006: Bennack Edith; Holzgrabe Ulrike
[A new weapon against beta-3 lactamases?]
Pharmazie in unserer Zeit 2006;35(5):387-8.
2006: Holzgrabe Ulrike
[Structure-activity relationships of penicillin G to tricyclic beta-lactams]
Pharmazie in unserer Zeit 2006;35(5):410-4.
2006: Holzgrabe Ulrike; Dingermann Theo; Zündorf Ilse
[An old pathway to new antibiotics--platensimycin]
Pharmazie in unserer Zeit 2006;35(5):388-9.
2006: Holzgrabe Ulrike
[Beta-lactam antibiotics as neuroprotectives]
Pharmazie in unserer Zeit 2006;35(5):387.
2006: Holzgrabe Ulrike; Bennack Edith
[Small change, large effect--a new vancomycin derivative against MRSA]
Pharmazie in unserer Zeit 2006;35(5):386.
2006: Holzgrabe Ulrike
[Perfect drug targeting. Glufosfamide a new derivative]
Pharmazie in unserer Zeit 2006;35(2):158-9.
2006: Holzgrabe Ulrike
[How does paracetamol work? A wider mosaic of action mechanisms]
Pharmazie in unserer Zeit 2006;35(2):100.
2006: Holzgrabe Ulrike
[Inhibition of virulence factors. A new approach to antibiotic development]
Pharmazie in unserer Zeit 2006;35(2):99.
2006: Holzgrabe Ulrike
[In Citation]
Pharmazie in unserer Zeit 2006;35(1):4.
2005: Tränkle Christian; Dittmann Andreas; Schulz Uwe; Weyand Oliver; Buller Stefan; Jöhren Kirstin; Heller Eberhard; Birdsall Nigel J M; Holzgrabe Ulrike; Ellis John; Höltje Hans Dieter; Mohr Klaus
Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.
Molecular pharmacology 2005;68(6):1597-610.
2005: Kapková Petra; Heller Eberhard; Unger Matthias; Folkers Gerd; Holzgrabe Ulrike
Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor.
Journal of medicinal chemistry 2005;48(23):7496-9.
2005: Bitar Yaser; Degel Björn; Schirmeister Tanja; Holzgrabe Ulrike
Comparison of the separation of aziridine isomers applying heptakis(2,3-di-O-methyl-6-sulfato)beta-CD and heptakis(2,3-di-O-acetyl-6-sulfato)beta-CD in aqueous and nonaqueous systems.
Electrophoresis 2005;26(20):3897-903.
2005: Weber C; Matingen S; Holzgrabe U
Batch variability of bacitracin: HPLC versus MEKC.
Pharmeuropa scientific notes 2005;2005(1):47-51.
2005: Kopec Susanne; Holzgrabe Ulrike
Impurity profile of amino acids?
Pharmeuropa scientific notes 2005;2005(1):39-45.
2005: Winter Werner; Deubner Ralph; Holzgrabe Ulrike
Multivariate analysis of nuclear magnetic resonance data--characterization of critical drug substance quality of gentamicin sulfate.
Journal of pharmaceutical and biomedical analysis 2005;38(5):833-9.
2005: Holzgrabe U; Deubner R; Schollmayer C; Waibel B
Quantitative NMR spectroscopy--applications in drug analysis.
Journal of pharmaceutical and biomedical analysis 2005;38(5):806-12.
2005: Unger Matthias; Laug Stefanie; Holzgrabe Ulrike
Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts.
Electrophoresis 2005;26(12):2430-6.
2005: Bitar Yaser; Degel Björn; Schirmeister Tanja; Holzgrabe Ulrike
Development and validation of a separation method for the diastereomers and enantiomers of aziridine-type protease inhibitors.
Electrophoresis 2005;26(12):2313-9.
2005: Krueger Wolfgang A; Bulitta Jurgen; Kinzig-Schippers Martina; Landersdorfer Cornelia; Holzgrabe Ulrike; Naber Kurt G; Drusano George L; Sörgel Fritz
Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.
Antimicrobial agents and chemotherapy 2005;49(5):1881-9.
2005: Neugebauer U; Szeghalmi A; Schmitt M; Kiefer W; Popp J; Holzgrabe U
Vibrational spectroscopic characterization of fluoroquinolones.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2005;61(7):1505-17.
2005: Bringmann Gerhard; Kajahn Inga; Neusüss Christian; Pelzing Matthias; Laug Stefanie; Unger Matthias; Holzgrabe Ulrike
Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry.
Electrophoresis 2005;26(7-8):1513-22.
2005: Muth Mathias; Sennwitz Matthias; Mohr Klaus; Holzgrabe Ulrike
Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents.
Journal of medicinal chemistry 2005;48(6):2212-7.
2005: Wang Yulin; Tang Kang; Inan Saadet; Siebert Daniel; Holzgrabe Ulrike; Lee David Y W; Huang Peng; Li Jian-Guo; Cowan Alan; Liu-Chen Lee-Yuan
Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.
The Journal of pharmacology and experimental therapeutics 2005;312(1):220-30.
2005: Müller Christa; Holzgrabe Ulrike
[Dear Colleagues]
Pharmazie in unserer Zeit 2005;34(6):443.
2005: Holzgrabe Ulrike
[New paths to highly effective tetracyclines]
Pharmazie in unserer Zeit 2005;34(4):258-9.
2005: Holzgrabe Ulrike
[Paclitaxel for Alzheimer treatment]
Pharmazie in unserer Zeit 2005;34(2):96.
2005: Holzgrabe Ulrike
[Artemisinin and successors]
Pharmazie in unserer Zeit 2005;34(2):95.
2004: Hoerr Verena; Stich August; Holzgrabe Ulrike
Critical aspects of analysis of Micrococcus luteus, Neisseria cinerea, and Pseudomonas fluorescens by means of capillary electrophoresis.
Electrophoresis 2004;25(18-19):3132-8.
2004: Kahle Claudia; Holzgrabe Ulrike
Determination of binding constants of cyclodextrin inclusion complexes with amino acids and dipeptides by potentiometric titration.
Chirality 2004;16(8):509-15.
2004: Kirchhoff C; Bitar Y; Ebel S; Holzgrabe U
Analysis of atropine, its degradation products and related substances of natural origin by means of reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 2004;1046(1-2):115-20.
2004: Schmitt Ulrich; Ertan Mevlut; Holzgrabe Ulrike
Chiral capillary electrophoresis: facts and fiction on the reproducibility of resolution with randomly substituted cyclodextrins.
Electrophoresis 2004;25(16):2801-7.
2004: Mohr Marion; Heller Eberhard; Ataie Ameneh; Mohr Klaus; Holzgrabe Ulrike
Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.
Journal of medicinal chemistry 2004;47(12):3324-7.
2004: Deubner Ralph; Holzgrabe Ulrike
Micellar electrokinetic capillary chromatography, high performance liquid chromatography and nuclear magnetic resonance--three orthogonal methods for characterization of critical drugs.
Journal of pharmaceutical and biomedical analysis 2004;35(3):459-67.
2004: Unger Matthias; Dreyer Michael; Specker Sven; Laug Stefanie; Pelzing Matthias; Neusüss Christian; Holzgrabe Ulrike; Bringmann Gerhard
Analytical characterisation of crude extracts from an African Ancistrocladus species using high-performance liquid chromatography and capillary electrophoresis coupled to ion trap mass spectrometry.
Phytochemical analysis : PCA 2004;15(1):21-6.
2004: Holzgrabe Ulrike
[Selective estrogen receptor modulators]
Pharmazie in unserer Zeit 2004;33(5):357-9.
2004: Holzgrabe Ulrike
[Flexibility in avoiding resistance]
Pharmazie in unserer Zeit 2004;33(5):349.
2004: Holzgrabe Ulrike
[A fungal substance against arteriosclerosis]
Pharmazie in unserer Zeit 2004;33(5):348-9.
2004: Holzgrabe Ulrike
[A riddle solved--why valerian-hops extract makes you drowsy]
Pharmazie in unserer Zeit 2004;33(5):348.
2004: Holzgrabe Ulrike
[A new in star in antibiotic heaven--daptomycin]
Pharmazie in unserer Zeit 2004;33(4):270.
2004: Holzgrabe Ulrike
[Protease inhibitors against hepatitis C]
Pharmazie in unserer Zeit 2004;33(3):160-1.
2004: Holzgrabe Ulrike
[HIV therapy: and an even newer treatment--PA-457]
Pharmazie in unserer Zeit 2004;33(3):160.
2004: Holzgrabe Ulrike
[And the path grows wider...ketolides and oxazolidinones in the pipeline]
Pharmazie in unserer Zeit 2004;33(1):56-7.
2004: Holzgrabe Ulrike
[New treatments against AIDS: fusion inhibitors]
Pharmazie in unserer Zeit 2004;33(1):6.
2003: Kapková Petra; Stiefl Nikolaus; Sürig Ulf; Engels Bernd; Baumann Knut; Holzgrabe Ulrike
Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type.
Archiv der Pharmazie 2003;336(11):523-40.
2003: Alptüzün Vildan; Kapková Petra; Baumann Knut; Erciyas Ercin; Holzgrabe Ulrike
Synthesis and biological activity of pyridinium-type acetylcholinesterase inhibitors.
The Journal of pharmacy and pharmacology 2003;55(10):1397-404.
2003: Wienen Frank; Holzgrabe Ulrike
A new micellar electrokinetic capillary chromatography method for separation of the components of the aminoglycoside antibiotics.
Electrophoresis 2003;24(17):2948-57.
2003: Staudt Markus; Tränkle Christian; Mohr Klaus; Holzgrabe Ulrike
Contribution of lateral substituents in symmetrical and non-symmetrical heptane-bisammonio compounds to the allosteric stabilization of N-methylscopolamine binding to muscarinic M2 receptors.
Archiv der Pharmazie 2003;336(8):385-9.
2003: Awadallah Bilal; Schmidt Peter C; Holzgrabe Ulrike; Wahl Martin A
Quantitation of talinolol and other beta-blockers by capillary electrophoresis for in vitro drug absorption studies.
Electrophoresis 2003;24(15):2627-32.
2003: Raab Thomas; Hauck Tobias; Knecht Anja; Schmitt Ulrich; Holzgrabe Ulrike; Schwab Wilfried
Tautomerism of 4-hydroxy-2,5-dimethyl-3(2H)-furanone: evidence for its enantioselective biosynthesis.
Chirality 2003;15(7):573-8.
2003: Zlotos D P; Buller S; Holzgrabe U; Mohr K
Bisquaternary dimers of strychnine and brucine. A new class of potent enhancers of antagonist binding to muscarinic M2 receptors.
Bioorganic & medicinal chemistry 2003;11(12):2627-34.
2003: Bringmann G; Hoerr V; Holzgrabe U; Stich A
Antitrypanosomal naphthylisoquinoline alkaloids and related compounds.
Die Pharmazie 2003;58(5):343-6.
2003: Gilsbach Ralf; Grossmüller Maren; Alptüzün Vildan; Erciyas Ercin; Tränkle Christian; Holzgrabe Ulrike; Mohr Klaus
Cooperative interactions at M2 muscarinic acetylcholine receptors: structure/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators.
Neurochemical research 2003;28(3-4):667-73.
2003: Holzgrabe Ulrike; Brandt Wolfgang
Mechanism of action of the diazabicyclononanone-type kappa-agonists.
Journal of medicinal chemistry 2003;46(8):1383-9.
2003: Muth Mathias; Bender Wiebke; Scharfenstein Olaf; Holzgrabe Ulrike; Balatkova Edith; Tränkle Christian; Mohr Klaus
Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding.
Journal of medicinal chemistry 2003;46(6):1031-40.
2003: Wienen Frank; Laug Stefanie; Baumann Knut; Schwab Albrecht; Just Stefan; Holzgrabe Ulrike
Determination of clotrimazole in mice plasma by capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis 2003;30(6):1879-87.
2003: Benyhe S; Márki A; Nachtsheim Corina; Holzgrabe Ulrike; Borsodi Anna
Kappa-receptor selective binding of opioid ligands with a heterocyclic bicyclo[3.3.1]nonan-9-one structure.
Acta biologica Hungarica 2003;54(2):147-55.
2003: Mohr K; Tränkle C; Holzgrabe U
Structure/activity relationships of M2 muscarinic allosteric modulators.
Receptors & channels 2003;9(4):229-40.
2003: Schäfer-Korting Monika; Holzgrabe Ulrike
[A silver lining on the horizon: new antimycotics]
Pharmazie in unserer Zeit 2003;32(2):154-6.
2003: Holzgrabe Ulrike
[Arrays overall]
Pharmazie in unserer Zeit 2003;32(2):91-2.
2003: Holzgrabe Ulrike; Schäfer-Korting Monika
[Antimycotics]
Pharmazie in unserer Zeit 2003;32(2):87.
2002: Unger Matthias; Holzgrabe Ulrike; Jacobsen Wolfgang; Cummins Carolyn; Benet Leslie Z
Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).
Planta medica 2002;68(12):1055-8.
2002: Raasch Alexandra; Scharfenstein Olaf; Tränkle Christian; Holzgrabe Ulrike; Mohr Klaus
Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators.
Journal of medicinal chemistry 2002;45(17):3809-12.
2002: Holzgrabe U; Cambareri A; Kuhl U; Siener T; Brandt W; Strassburger W; Friderichs E; Englberger W; Kögel B; Haurand M
Diazabicyclononanones, a potent class of kappa opioid analgesics.
Farmaco (Società chimica italiana : 1989) 2002;57(7):531-4.
2002: Heller Barbara; Sundermann Bernd; Buschmann Helmut; Drexler Hans-Joachim; You Jingsong; Holzgrabe Ulrike; Heller Eberhard; Oehme Günther
Photocatalyzed [2 + 2 + 2]-cycloaddition of nitriles with acetylene: an effective method for the synthesis of 2-pyridines under mild conditions.
The Journal of organic chemistry 2002;67(13):4414-22.
2002: Wedig Maike; Novatchev Nikolai; Worch Tina; Laug Stefanie; Holzgrabe Ulrike
Evaluation of the impurity profile of alcuronium by means of capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis 2002;28(5):983-90.
2002: Novatchev Nikolai; Holzgrabe Ulrike
Evaluation of amino sugar, low molecular peptide and amino acid impurities of biotechnologically produced amino acids by means of CE.
Journal of pharmaceutical and biomedical analysis 2002;28(3-4):475-86.
2002: Süss Falko; Kahle Claudia; Holzgrabe Ulrike; Scriba Gerhard K E
Studies on the chiral recognition of peptide enantiomers by neutral and sulfated beta-cyclodextrin and heptakis-(2,3-di-O-acetyl)-beta-cyclodextrin using capillary electrophoresis and nuclear magnetic resonance.
Electrophoresis 2002;23(9):1301-7.
2002: Unger Matthias; Jacobsen Wolfgang; Holzgrabe Ulrike; Benet Leslie Z
Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;767(2):245-53.
2002: Wedig M; Laug S; Christians T; Thunhorst M; Holzgrabe U
Do we know the mechanism of chiral recognition between cyclodextrins and analytes?
Journal of pharmaceutical and biomedical analysis 2002;27(3-4):531-40.
2002: Holzgrabe Ulrike
[Ibuprofen for Alzheimer's?]
Pharmazie in unserer Zeit 2002;31(2):130.
2002: Holzgrabe Ulrike; Christians Thorsten
The use of cyclodextrin-modified capillary electrophoresis in the determination of the enantiomeric purity.
Journal of capillary electrophoresis and microchip technology 2002;7(1-2):23-9.
2001: Novatchev N; Holzgrabe U
Evaluation of the impurity profile of amino acids by means of CE.
Journal of pharmaceutical and biomedical analysis 2001;26(5-6):779-89.
2001: Holzgrabe U; Steinert M
N1-phenyl substituted 4-quinolones of tuberculostatic activity.
Die Pharmazie 2001;56(11):850-1.
2001: Wedig M; Thunhorst M; Laug S; Decker M; Lehmann J; Holzgrabe U
Enantioseparation of linear and cyclic chiral bis(phenethyl)amines by means of cyclodextrin-modified capillary electrophoresis.
Fresenius' journal of analytical chemistry 2001;371(2):212-7.
2001: Schmitt U; Bojarski J; Holzgrabe U
Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis.
Electrophoresis 2001;22(15):3237-42.
2001: Hellriegel C; Händel H; Wedig M; Steinhauer S; Sörgel F; Albert K; Holzgrabe U
Study on the chiral recognition of the enantiomers of ephedrine derivatives with neutral and sulfated heptakis(2,3-O-diacetyl)-beta-cyclodextrins using capillary electrophoresis, UV, nuclear magnetic resonance spectroscopy and mass spectrometry.
Journal of chromatography. A 2001;914(1-2):315-24.
2001: Christians T; Holzgrabe U
New single-isomer chiral selector for capillary electrophoresis: the highly water-soluble heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin.
Journal of chromatography. A 2001;911(2):249-57.
2001: Holzgrabe U
[Where are quinolones going? New agents in development]
Pharmazie in unserer Zeit 2001;30(5):446-8.
2000: Christians T; Holzgrabe U
Enantioseparation of dihydropyridine derivatives by means of neutral and negatively charged beta-cyclodextrin derivatives using capillary electrophoresis.
Electrophoresis 2000;21(17):3609-17.
2000: Siener T; Cambareri A; Kuhl U; Englberger W; Haurand M; Kögel B; Holzgrabe U
Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones.
Journal of medicinal chemistry 2000;43(20):3746-51.
2000: Kuhl U; Englberger W; Haurand M; Holzgrabe U
Diazabicyclo[3.3.1]nonanone-type ligands for the opioid receptors.
Archiv der Pharmazie 2000;333(7):226-30.
2000: Botero Cid H M; Tränkle C; Baumann K; Pick R; Mies-Klomfass E; Kostenis E; Mohr K; Holzgrabe U
Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.
Journal of medicinal chemistry 2000;43(11):2155-64.
2000: Holzgrabe U; Bender W; Cid H M; Staudt M; Pick R; Pfletschinger C; Balatková E; Tränkle C; Mohr K
Ligands for the common allosteric site of acetylcholine M2-receptors: development and application.
Pharmaceutica acta Helvetiae 2000;74(2-3):149-55.
2000: Bender W; Staudt M; Tränkle C; Mohr K; Holzgrabe U
Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors.
Life sciences 2000;66(18):1675-82.
1999: Wedig M; Holzgrabe U
Resolution of ephedrine derivatives by means of neutral and sulfated heptakis(2,3-di-O-acetyl)beta-cyclodextrins using capillary electrophoresis and nuclear magnetic resonance spectroscopy.
Electrophoresis 1999;20(13):2698-704.
1999: Christians T; Diewald D; Wessler C; Otte Y; Lehmann J; Holzgrabe U
Resolution of newly synthesized racemic dihydropyridines with different chiral selectors by means of capillary electrophoresis.
Journal of chromatography. A 1999;853(1-2):455-60.
1999: Inkmann E; Holzgrabe U
1H and 13C nuclear magnetic resonance studies of the sites of protonation in itraconazole and fluconazole.
Journal of pharmaceutical and biomedical analysis 1999;20(1-2):297-307.
1999: Wedig M; Holzgrabe U
Enantioseparation of tropa alkaloids by means of anionic cyclodextrin-modified capillary electrophoresis.
Electrophoresis 1999;20(7):1555-60.
1999: Nassif-Makki T; Tränkle C; Zlotos D; Bejeuhr G; Cambareri A; Pfletschinger C; Kostenis E; Mohr K; Holzgrabe U
Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements.
Journal of medicinal chemistry 1999;42(5):849-58.
1999: Holzgrabe U; Heisig P
[New 4-quinolone derivatives in review]
Pharmazie in unserer Zeit 1999;28(1):30-5.
1998: Zlotos G; Oehlmann M; Nickel P; Holzgrabe U
Determination of protein binding of gyrase inhibitors by means of continuous ultrafiltration.
Journal of pharmaceutical and biomedical analysis 1998;18(4-5):847-58.
1998: Holzgrabe U; Diehl B W; Wawer I
NMR spectroscopy in pharmacy.
Journal of pharmaceutical and biomedical analysis 1998;17(4-5):557-616.
1998: Tränkle C; Mies-Klomfass E; Cid M H; Holzgrabe U; Mohr K
Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.
Molecular pharmacology 1998;54(1):139-45.
1998: Engler M; Rüsing G; Sörgel F; Holzgrabe U
Defluorinated sparfloxacin as a new photoproduct identified by liquid chromatography coupled with UV detection and tandem mass spectrometry.
Antimicrobial agents and chemotherapy 1998;42(5):1151-9.
1998: Zlotos G; Bücker A; Kinzig-Schippers M; Sorgel F; Holzgrabe U
Plasma protein binding of gyrase inhibitors.
Journal of pharmaceutical sciences 1998;87(2):215-20.
1998: Staudt M; Tränkle C; Mohr K; Holzgrabe U
Contribution of lateral substituents in heptane-bisammonium derivatives to the allosteric stabilization of antagonist binding to M2-receptors.
Life sciences 1998;62(5):423-9.
1997: Inkmann E; Holzgrabe U; Hesse K F
Stability of mono- and bisbenzyloxime ethers of the acetylcholinesterase reactivator TMB-4.
Die Pharmazie 1997;52(10):764-74.
1997: Holzgrabe U
[New antiepileptics in review]
Pharmazie in unserer Zeit 1997;26(3):152-6.
1997: Holzgrabe U; Nachtsheim C; Siener T; Drosihn S; Brandt W
[Opioid agonists and antagonists, opioid receptors]
Die Pharmazie 1997;52(1):4-22.
1996: Holzgrabe U; Hopfinger A J
Conformational analysis, molecular shape comparison, and pharmacophore identification of different allosteric modulators of muscarinic receptors.
Journal of chemical information and computer sciences 1996;36(5):1018-24.
1996: Holzgrabe U; Wagener M; Gasteiger J
Comparison of structurally different allosteric modulators of muscarinic receptors by self-organizing neural networks.
Journal of molecular graphics 1996;14(4):185-93, 217-21.
1996: Brandt W; Drosihn S; Haurand M; Holzgrabe U; Nachtsheim C
Search for the pharmacophore in kappa-agonistic diazabicyclo[3.3.1]nonan-9-one-1,5-diesters and arylacetamides.
Archiv der Pharmazie 1996;329(6):311-23.
1996: Jürgens J; Schedletzky H; Heisig P; Seydel J K; Wiedemann B; Holzgrabe U
Syntheses and biological activities of new N1-aryl substituted quinolone antibacterials.
Archiv der Pharmazie 1996;329(4):179-90.
1995: Gasteiger J; Holzgrabe U; Kostenis E; Mohr K; Sürig U; Wagener M
Variation of the oxime function of bispyridinium-type allosteric modulators of M2-cholinoceptors.
Die Pharmazie 1995;50(2):99-105.
1994: Holzgrabe U
[Anatoxin-a: a bacterial organophosphate]
Pharmazie in unserer Zeit 1994;23(5):301-2.
1994: Botero Cid M H; Holzgrabe U; Kostenis E; Mohr K; Tränkle C
Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.
Journal of medicinal chemistry 1994;37(10):1439-45.
1994: Bejeuhr G; Blaschke G; Holzgrabe U; Mohr K; Sürig U; Terfloth G
A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts.
The Journal of pharmacy and pharmacology 1994;46(2):108-12.
1992: Holzgrabe U; Erciyas E
[Synthesis and stereochemistry of potentially powerful analgesics: 2,4-m-diaryl substituted 3,7-diazabicyclo(3,3,1)nonan-9-one-1,5-diesters]
Archiv der Pharmazie 1992;325(10):657-63.
1990: Holzgrabe U; Bejeuhr G
[Phosphoric acid esters: poisoning and therapy at the molecular sight]
Pharmazie in unserer Zeit 1990;19(6):247-56.

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