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Hermann-Georg Holzhütter

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Christine Huchzermeyer; Nikolaus Berndt; Hermann-Georg Holzhütter; Oliver Kann
Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.
Matthias König; Hermann-Georg Holzhütter
Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy.
Matthias König; Andreas Dräger; Hermann-Georg Holzhütter
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All Publications

2013: Christine Huchzermeyer; Nikolaus Berndt; Hermann-Georg Holzhütter; Oliver Kann
Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2013;33(2):263-71.
2012: Matthias König; Hermann-Georg Holzhütter
Kinetic modeling of human hepatic glucose metabolism in type 2 diabetes mellitus predicts higher risk of hypoglycemic events in rigorous insulin therapy.
The Journal of biological chemistry 2012;287(44):36978-89.
2012: Matthias König; Andreas Dräger; Hermann-Georg Holzhütter
CySBML: a Cytoscape plugin for SBML.
Bioinformatics (Oxford, England) 2012;28(18):2402-3.
2012: Bernd Binder; Hermann-Georg Holzhütter
A hypothetical model of cargo-selective rab recruitment during organelle maturation.
Cell biochemistry and biophysics 2012;63(1):59-71.
2012: Hermann-Georg Holzhütter; Jörg Lippert; Tobias Preusser; Dirk Drasdo; Adriano M Henney
The virtual liver: a multidisciplinary, multilevel challenge for systems biology.
Wiley interdisciplinary reviews. Systems biology and medicine 2012;4(3):221-35.
2012: Susanna Bazzani; Andreas Hoppe; Hermann-Georg Holzhütter
Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism.
BMC systems biology 2012;6():118.
2012: Anja Karlstädt; Vera Regitz-Zagrosek; Hugo Sanchez Ruderisch; Daniela Fliegner; Georgios Kararigas; Hermann-Georg Holzhütter
CardioNet: a human metabolic network suited for the study of cardiomyocyte metabolism.
BMC systems biology 2012;6():114.
2012: Matthias König; Sascha Bulik; Hermann-Georg Holzhütter
Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism.
PLoS computational biology 2012;8(6):e1002577.
2012: Nikolaus Berndt; Sascha Bulik; Hermann-Georg Holzhütter
Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species.
International journal of cell biology 2012;2012():757594.
2012: Sven Knüppel; Young-Ae Lee; Ingo Marenholz; Anja Bauerfeind; Jorge Esparza-Gordillo; Hermann-Georg Holzhütter; Andreas Ruether; Stephan Weidinger; Klaus Rohde
Multi-locus stepwise regression: a haplotype-based algorithm for finding genetic associations applied to atopic dermatitis.
BMC medical genetics 2012;13():8.
2011: Christoph Gille; Andreas Hoppe; Katrin Hübner; Hermann-Georg Holzhütter
Metannogen: annotation of biological reaction networks.
Bioinformatics (Oxford, England) 2011;27(19):2763-4.
2011: Andreas Hoppe; Christine Richter; Hermann-Georg Holzhütter
Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes.
Bio Systems 2011;105(2):122-9.
2011: Anique Herling; Sascha Bulik; Matthias König; Hermann-Georg Holzhütter
Enzymatic features of the glucose metabolism in tumor cells.
The FEBS journal 2011;278(14):2436-59.
2011: Nikolaus Berndt; Sabrina Hoffmann; Jan Benda; Hermann-Georg Holzhütter
The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model.
Journal of theoretical biology 2011;276(1):42-9.
2011: Andreas Hoppe; Sabrina Hoffmann; Andreas Gerasch; Christoph Gille; Hermann-Georg Holzhütter
FASIMU: flexible software for flux-balance computation series in large metabolic networks.
BMC bioinformatics 2011;12():28.
2010: Christoph Gille; Christian Bölling; Andreas Hoppe; Sascha Bulik; Sabrina Hoffmann; Katrin Hübner; Anja Karlstädt; Ramanan Ganeshan; Matthias König; Kristian Rother; Michael Weidlich; Jörn Behre; Hermann-Georg Holzhütter
HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.
Molecular systems biology 2010;6():411.
2010: Matthias König; Hermann-Georg Holzhütter
Fluxviz - cytoscape plug-in for visualization of flux distributions in networks.
Genome informatics. International Conference on Genome Informatics 2010;24(1):96-103.
2010: Carola Huthmacher; Andreas Hoppe; Sascha Bulik; Hermann-Georg Holzhütter
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.
BMC systems biology 2010;4():120.
2009: Sabrina Hoffmann; Hermann-Georg Holzhütter
Uncovering metabolic objectives pursued by changes of enzyme levels.
Annals of the New York Academy of Sciences 2009;1158():57-70.
2009: Dawadschargal Bech-Otschir; Annett Helfrich; Cordula Enenkel; Gesa Consiglieri; Michael Seeger; Hermann-Georg Holzhütter; Burkhardt Dahlmann; Peter-M Kloetzel
Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome.
Nature structural & molecular biology 2009;16(2):219-25.
2009: Bernd Binder; Andrean Goede; Nikolaus Berndt; Hermann-Georg Holzhütter
A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles.
PloS one 2009;4(12):e8295.
2009: Hartmut Schlüter; Rolf Apweiler; Hermann-Georg Holzhütter; Peter R Jungblut
Finding one's way in proteomics: a protein species nomenclature.
Chemistry Central journal 2009;3():11.
2009: Sascha Bulik; Sergio Grimbs; Carola Huthmacher; Joachim Selbig; Hermann-Georg Holzhütter
Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws--a promising method for speeding up the kinetic modelling of complex metabolic networks.
The FEBS journal 2009;276(2):410-24.
2008: Carola Huthmacher; Christoph Gille; Hermann-Georg Holzhütter
A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling.
Journal of theoretical biology 2008;252(3):456-64.
2008: Katrin Hübner; Thomas Schwager; Karl Winkler; Jens-Georg Reich; Hermann-Georg Holzhütter
Computational lipidology: predicting lipoprotein density profiles in human blood plasma.
PLoS computational biology 2008;4(5):e1000079.
2008: Michele Mishto; Fabio Luciani; Hermann-Georg Holzhütter; Elena Bellavista; Aurelia Santoro; Kathrin Textoris-Taube; Claudio Franceschi; Peter-M Kloetzel; Alexey Zaikin
Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics.
Journal of molecular biology 2008;377(5):1607-17.
2008: Mark M Schatz; Björn Peters; Nadja Akkad; Nina Ullrich; Alejandra Nacarino Martinez; Oliver Carroll; Sascha Bulik; Hans-Georg Rammensee; Peter van Endert; Hermann-Georg Holzhütter; Stefan Tenzer; Hansjörg Schild
Characterizing the N-terminal processing motif of MHC class I ligands.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):3210-7.
2008: Chirstoph Gille; Andreas Hoppe; Hermann-Georg Holzhütter
Web-links as a means to document annotated sequence and 3D-structure alignments in systems biology.
Genome informatics. International Conference on Genome Informatics 2008;20():277-84.
2008: Benjamin Sefa Menküc; Christoph Gille; Hermann-Georg Holzhütter
Computer aided optimization of carbon atom labeling for tracer experiments.
Genome informatics. International Conference on Genome Informatics 2008;20():270-6.
2007: Jan Saam; Igor Ivanov; Matthias Walther; Hermann-Georg Holzhütter; Hartmut Kuhn
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13319-24.
2007: Sabrina Hoffmann; Andreas Hoppe; Hermann-Georg Holzhütter
Pruning genome-scale metabolic models to consistent ad functionem networks.
Genome informatics. International Conference on Genome Informatics 2007;18():308-19.
2007: Carola Huthmacher; Christoph Gille; Hermann-Georg Holzhütter
Computational analysis of protein-protein interactions in metabolic networks of Escherichia coli and yeast.
Genome informatics. International Conference on Genome Informatics 2007;18():162-72.
2007: Sergio Grimbs; Joachim Selbig; Sascha Bulik; Hermann-Georg Holzhütter; Ralf Steuer
The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks.
Molecular systems biology 2007;3():146.
2007: Andreas Hoppe; Sabrina Hoffmann; Hermann-Georg Holzhütter
Including metabolite concentrations into flux balance analysis: thermodynamic realizability as a constraint on flux distributions in metabolic networks.
BMC systems biology 2007;1():23.
2007: Christoph Gille; Sabrina Hoffmann; Hermann-Georg Holzhütter
METANNOGEN: compiling features of biochemical reactions needed for the reconstruction of metabolic networks.
BMC systems biology 2007;1():5.
2006: Hermann-Georg Holzhütter
The generalized flux-minimization method and its application to metabolic networks affected by enzyme deficiencies.
Bio Systems 2006;83(2-3):98-107.
2006: Sabrina Hoffmann; Andreas Hoppe; Hermann-Georg Holzhütter
Composition of metabolic flux distributions by functionally interpretable minimal flux modes (MinModes).
Genome informatics. International Conference on Genome Informatics 2006;17(1):195-207.
2005: Sascha Bulik; Björn Peters; Hermann-Georg Holzhütter
Quantifying the contribution of defective ribosomal products to antigen production: a model-based computational analysis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):7957-64.
2005: Hartmut Kuhn; Jan Saam; Sebastian Eibach; Hermann-Georg Holzhütter; Igor Ivanov; Matthias Walther
Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure.
Biochemical and biophysical research communications 2005;338(1):93-101.
2005: Igor Ivanov; Jan Saam; Hartmut Kuhn; Hermann-Georg Holzhütter
Dual role of oxygen during lipoxygenase reactions.
The FEBS journal 2005;272(10):2523-35.
2005: Stefan Tenzer; Björn Peters; Sascha Bulik; Oliver Schoor; Claudia Lemmel; M M Schatz; Peter-M Kloetzel; Hans-Georg Rammensee; Hansjörg Schild; Hermann-Georg Holzhütter
Modeling the MHC class I pathway by combining predictions of proteasomal cleavage, TAP transport and MHC class I binding.
Cellular and molecular life sciences : CMLS 2005;62(9):1025-37.
2005: Christoph Gille; Sabrina Hoffmann; Hermann-Georg Holzhütter
Combining bioinformatics resources for the structural modelling of eukaryotic metabolic networks.
Genome informatics. International Conference on Genome Informatics 2005;16(1):223-32.
2004: Scott Holzhütter; Hermann-Georg Holzhütter
Computational design of reduced metabolic networks.
Chembiochem : a European journal of chemical biology 2004;5(10):1401-22.
2004: Hermann-Georg Holzhütter
The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks.
European journal of biochemistry / FEBS 2004;271(14):2905-22.
2004: Guido Epple; Kristina Langfeld; Michael Baier; Hermann-Georg Holzhütter; Wolf-Dieter Schleuning; Eckart Köttgen; Reinhard Gessner; Michael Praus
Both lysine-clusters of the NH2-terminal prion-protein fragment PrP23-110 are essential for t-PA mediated plasminogen activation.
Thrombosis and haemostasis 2004;91(3):465-72.
2004: Sascha Bulik; Bjoern Peters; Christian Ebeling; Hermann-Georg Holzhütter
Cytosolic processing of proteasomal cleavage products can enhance the presentation efficiency of MHC-1 epitopes.
Genome informatics. International Conference on Genome Informatics 2004;15(1):24-34.
2003: Björn Peters; Sascha Bulik; Robert Tampe; Peter van Endert; Hermann-Georg Holzhütter
Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1741-9.
2003: Michael Praus; Gerhard Kettelgerdes; Michael Baier; Hermann-Georg Holzhütter; Peter Jungblut; Manuela Maissen; Guido Epple; Wolf-Dieter Schleuning; Eckart Köttgen; Adriano Aguzzi; Reinhard Gessner
Stimulation of plasminogen activation by recombinant cellular prion protein is conserved in the NH2-terminal fragment PrP23-110.
Thrombosis and haemostasis 2003;89(5):812-9.
2003: Joerg Hakenberg; Alexander K Nussbaum; Hansjörg Schild; Hans-Georg Rammensee; Christina Kuttler; Hermann-Georg Holzhütter; Peter-M Kloetzel; Stefan H E Kaufmann; Hans-Joachim Mollenkopf
MAPPP: MHC class I antigenic peptide processing prediction.
Applied bioinformatics 2003;2(3):155-8.
2003: Ralf Stohwasser; Hermann-Georg Holzhütter; Undine Lehmann; Peter Henklein; Peter-M Kloetzel
Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit.
Biological chemistry 2003;384(1):39-49.
2002: Edda Klipp; Reinhart Heinrich; Hermann-Georg Holzhütter
Prediction of temporal gene expression. Metabolic opimization by re-distribution of enzyme activities.
European journal of biochemistry / FEBS 2002;269(22):5406-13.
2002: Björn Peters; Hermann-Georg Holzhütter
In vitro phototoxicity testing: development and validation of a new concentration response analysis software and biostatistical analyses related to the use of various prediction models.
Alternatives to laboratory animals : ATLA 2002;30(4):415-32.
2002: Björn Peters; Katharina Janek; Ulrike Kuckelkorn; Hermann-Georg Holzhütter
Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation.
Journal of molecular biology 2002;318(3):847-62.
2001: Wolfgang Kuon; Hermann-Georg Holzhütter; Heiner Appel; M Grolms; Simon Kollnberger; A Traeder; Peter Henklein; E Weiss; Andreas Thiel; Roland Lauster; Paul Bowness; Andreas Radbruch; Peter-M Kloetzel; Joachim Sieper
Identification of HLA-B27-restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B27-associated diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4738-46.
2001: H Pospisil; Hermann-Georg Holzhütter
A compartment model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye.
Alternatives to laboratory animals : ATLA 2001;29(3):347-65.
2000: Ralf Stohwasser; Ulrike Salzmann; J Giesebrecht; P M Kloetzel; Hermann-Georg Holzhütter
Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.
European journal of biochemistry / FEBS 2000;267(20):6221-30.
1999: Dietmar M W Zaiss; Sybille Standera; Hermann-Georg Holzhütter; Peter-M Kloetzel; Alice J A M Sijts
The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.
FEBS letters 1999;457(3):333-8.