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Gene Homandberg

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

Living Beings

Cattle

Concepts & Ideas

Disorders

Osteoarthritis

Procedures

Culture Techniques

Genes & Molecular Sequences

Amino Acid Sequence

Phenomena

Western Blotting

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Co-Publications
Name
12
Hui, F
10
Wen, C
6
Kuettner, Klaus
5
Ummadi, Vijay
4
Williams, James
4
Koepp, Holger
4
Kang, Hellan
3
Pichika, R
3
Cole, Ada
1
Eger, Wolfgang
1
Huch, Klaus
1
Masuda, Koichi
1
Pichika, Rajeswari
1
Thonar, Eugene
1
Knudson, Cheryl

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Publications

TOP 3
Ding L; Guo D; Homandberg G A
Fibronectin fragments mediate matrix metalloproteinase upregulation and cartilage damage through proline rich tyrosine kinase 2, c-src, NF-kappaB and protein kinase Cdelta.
Guo D; Ding L; Homandberg G A
Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments.
Ding L; Guo D; Homandberg G A
The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin.

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All Publications

2009: Ding L; Guo D; Homandberg G A
Fibronectin fragments mediate matrix metalloproteinase upregulation and cartilage damage through proline rich tyrosine kinase 2, c-src, NF-kappaB and protein kinase Cdelta.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2009;17(10):1385-92.
2009: Guo D; Ding L; Homandberg G A
Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009;58(3):161-9.
2008: Ding L; Guo D; Homandberg G A
The cartilage chondrolytic mechanism of fibronectin fragments involves MAP kinases: comparison of three fragments and native fibronectin.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1253-62.
2006: Homandberg G A; Guo D; Ray L M; Ding L
Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(8):793-806.
2005: Aota Yoichi; An Howard S; Homandberg Gene; Thonar Eugene J M-A; Andersson Gunnar B J; Pichika Rajeswari; Masuda Koichi
Differential effects of fibronectin fragment on proteoglycan metabolism by intervertebral disc cells: a comparison with articular chondrocytes.
Spine 2005;30(7):722-8.
2004: Homandberg G A; Ummadi V; Kang H
Hyaluronan enhances cartilage repair through low grade tissue remodeling involving cytokines and matrix metalloproteinases.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53(10):534-43.
2004: Pichika R; Homandberg G A
Fibronectin fragments elevate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in bovine cartilage and iNOS inhibitors block fibronectin fragment mediated damage and promote repair.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53(8):405-12.
2004: Homandberg G A; Ummadi V; Kang H
The role of insulin-like growth factor-I in hyaluronan mediated repair of cultured cartilage explants.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53(8):396-404.
2003: Dang Y; Cole A A; Homandberg G A
Comparison of the catabolic effects of fibronectin fragments in human knee and ankle cartilages.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(7):538-47.
2003: Homandberg Gene A; Ummadi Vijay; Kang Hellan
High molecular weight hyaluronan promotes repair of IL-1 beta-damaged cartilage explants from both young and old bovines.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(3):177-86.
2003: Williams J M; Zhang J; Kang H; Ummadi V; Homandberg G A
The effects of hyaluronic acid on fibronectin fragment mediated cartilage chondrolysis in skeletally mature rabbits.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(1):44-9.
2002: Homandberg G A; Costa V; Wen C
Fibronectin fragments active in chondrocytic chondrolysis can be chemically cross-linked to the alpha5 integrin receptor subunit.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(12):938-49.
2002: Purple C R; Untermann T G; Pichika R; Homandberg G A
Fibronectin fragments upregulate insulin-like growth factor binding proteins in chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(9):734-46.
2002: Homandberg G A; Costa V; Ummadi V; Pichika R
Antisense oligonucleotides to the integrin receptor subunit alpha(5) decrease fibronectin fragment mediated cartilage chondrolysis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(5):381-93.
2001: Homandberg G A; Kang Y; Zhang J; Cole A A; Williams J M
A single injection of fibronectin fragments into rabbit knee joints enhances catabolism in the articular cartilage followed by reparative responses but also induces systemic effects in the non-injected knee joints.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):673-83.
2001: Homandberg G A
Cartilage damage by matrix degradation products: fibronectin fragments.
Clinical orthopaedics and related research 2001;(391 Suppl):S100-7.
1999: Kang Y; Eger W; Koepp H; Williams J M; Kuettner K E; Homandberg G A
Hyaluronan suppresses fibronectin fragment-mediated damage to human cartilage explant cultures by enhancing proteoglycan synthesis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1999;17(6):858-69.
1999: Homandberg G A
Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments.
Frontiers in bioscience : a journal and virtual library 1999;4():D713-30.
1999: Koepp H E; Sampath K T; Kuettner K E; Homandberg G A
Osteogenic protein-1 (OP-1) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1999;48(4):199-204.
1998: Kang Y; Koepp H; Cole A A; Kuettner K E; Homandberg G A
Cultured human ankle and knee cartilage differ in susceptibility to damage mediated by fibronectin fragments.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(5):551-6.
1998: Homandberg G A; Wen C; Hui F
Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(4):231-44.
1998: Homandberg G A; Wen C
Exposure of cartilage to a fibronectin fragment amplifies catabolic processes while also enhancing anabolic processes to limit damage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1998;16(2):237-46.
1997: Homandberg G A; Davis G; Maniglia C; Shrikhande A
Cartilage chondrolysis by fibronectin fragments causes cleavage of aggrecan at the same site as found in osteoarthritic cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(6):450-3.
1997: Homandberg G A; Wen C; Hui F
Agents that block fibronectin fragment-mediated cartilage damage also promote repair.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1997;46(11):467-71.
1997: Homandberg G A; Hui F; Wen C; Kuettner K E; Williams J M
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: I. In vitro.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(5):309-19.
1997: Williams J M; Plaza V; Hui F; Wen C; Kuettner K E; Homandberg G A
Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: II. In vivo.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1997;5(4):235-40.
1997: Homandberg G A; Hui F; Wen C; Purple C; Bewsey K; Koepp H; Huch K; Harris A
Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines.
The Biochemical journal 1997;321 ( Pt 3)():751-7.
1996: Homandberg G A; Hui F; Wen C
Fibronectin fragment mediated cartilage chondrolysis. II. Reparative effects of anti-oxidants.
Biochimica et biophysica acta 1996;1317(2):143-8.
1996: Homandberg G A; Hui F; Wen C
Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants.
Biochimica et biophysica acta 1996;1317(2):134-42.
1996: Homandberg G A; Hui F
Association of proteoglycan degradation with catabolic cytokine and stromelysin release from cartilage cultured with fibronectin fragments.
Archives of biochemistry and biophysics 1996;334(2):325-31.
1996: Bewsey K E; Wen C; Purple C; Homandberg G A
Fibronectin fragments induce the expression of stromelysin-1 mRNA and protein in bovine chondrocytes in monolayer culture.
Biochimica et biophysica acta 1996;1317(1):55-64.
1995: Chow G; Knudson C B; Homandberg G; Knudson W
Increased expression of CD44 in bovine articular chondrocytes by catabolic cellular mediators.
The Journal of biological chemistry 1995;270(46):27734-41.
1994: Homandberg G A; Hui F
High concentrations of fibronectin fragments cause short-term catabolic effects in cartilage tissue while lower concentrations cause continuous anabolic effects.
Archives of biochemistry and biophysics 1994;311(2):213-8.
1994: Xie D L; Hui F; Meyers R; Homandberg G A
Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis.
Archives of biochemistry and biophysics 1994;311(2):205-12.
1994: Homandberg G A; Hui F
Arg-Gly-Asp-Ser peptide analogs suppress cartilage chondrolytic activities of integrin-binding and nonbinding fibronectin fragments.
Archives of biochemistry and biophysics 1994;310(1):40-8.
1993: Xie D; Hui F; Homandberg G A
Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitro.
Archives of biochemistry and biophysics 1993;307(1):110-8.
1993: Xie D; Homandberg G A
Fibronectin fragments bind to and penetrate cartilage tissue resulting in proteinase expression and cartilage damage.
Biochimica et biophysica acta 1993;1182(2):189-96.
1993: Homandberg G A; Meyers R; Williams J M
Intraarticular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivo.
The Journal of rheumatology 1993;20(8):1378-82.
1993: Xie D L; Meyers R; Homandberg G A
Release of elastase from monocytes adherent to a fibronectin-gelatin surface.
Blood 1993;81(1):186-92.
1992: Xie D L; Meyers R; Homandberg G A
Fibronectin fragments in osteoarthritic synovial fluid.
The Journal of rheumatology 1992;19(9):1448-52.
1992: Homandberg G A; Meyers R; Xie D L
Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture.
The Journal of biological chemistry 1992;267(6):3597-604.
1992: Homandberg G A; Meyers R; Aydelotte M; Tripier D; Kuettner K E
Isolation and characterization of an abundant elastase inhibitor from NaCl extracts of bovine nasal septa and articular cartilage.
Connective tissue research 1992;28(4):289-305.
1991: Kang K; Schwarz D; Sky-Peck H; Kuettner K E; Homandberg G A
Novel method of purification of human leukocytic elastase using adsorption on a high-performance liquid chromatography gel permeation column.
Journal of chromatography 1991;567(1):57-63.
1990: Lohr K M; Kurth C A; Xie D L; Seyer J M; Homandberg G A
The amino-terminal 29- and 72-Kd fragments of fibronectin mediate selective monocyte recruitment.
Blood 1990;76(10):2117-24.
1990: Homandberg G A; Wai T
Insertion of fibrin peptides into urokinase enhances fibrin affinity.
Thrombosis research 1990;58(4):403-12.
1990: Homandberg G A; Wai T
Reduction of disulfides in urokinase and insertion of a synthetic peptide.
Biochimica et biophysica acta 1990;1038(2):209-15.
1989: Homandberg G A; Wai T
Comparison of affinities of urokinase and tissue plasminogen activator for fibrin clots.
Thrombosis research 1989;55(4):493-501.
1989: Homandberg G A; Litwiller R D; Peanasky R J
Carboxypeptidase inhibitors from Ascaris suum: the primary structure.
Archives of biochemistry and biophysics 1989;270(1):153-61.
1984: Peanasky R J; Bentz Y; Homandberg G A; Minor S T; Babin D R
The isoinhibitors of chymotrypsin/elastase from Ascaris lumbricoides: the reactive site.
Archives of biochemistry and biophysics 1984;232(1):135-42.
1980: Homandberg G A; Minor S T; Peanasky R J
Modification of the carboxypeptidase A active site residue Glu-270 prevents interaction with a protein protease inhibitor from Ascaris.
Biochimica et biophysica acta 1980;612(2):384-94.

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