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Gregg Homanics

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Yuri A Blednov; D Chandra; J M Benavidez; M Black; Gregg E Homanics; U Rudolph; R Adron Harris
Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.
Mark W Zimmerman; Gregg E Homanics; John S Lazo
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.
Cecilia Borghese; Edmond I Eger; Angel Ho; Gregg E Homanics; David M Lovinger; S John Mihic; S Irene Oh; Wei Xiong; Li Zhang; R Adron Harris
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

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2013: Yuri A Blednov; D Chandra; J M Benavidez; M Black; Gregg E Homanics; U Rudolph; R Adron Harris
Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.
Neuropharmacology 2013;67():46-56.
2013: Mark W Zimmerman; Gregg E Homanics; John S Lazo
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.
PloS one 2013;8(3):e58300.
2012: Cecilia Borghese; Edmond I Eger; Angel Ho; Gregg E Homanics; David M Lovinger; S John Mihic; S Irene Oh; Wei Xiong; Li Zhang; R Adron Harris
Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.
Anesthesiology 2012;117(4):765-71.
2012: Nicole Sabaliauskas; Hui Shen; Sheryl S Smith; Gregg E Homanics; Chiye Aoki
Knockout of the γ-aminobutyric acid receptor subunit α4 reduces functional δ-containing extrasynaptic receptors in hippocampal pyramidal cells at the onset of puberty.
Brain research 2012;1450():11-23.
2012: Yuri A Blednov; Jill M Benavidez; Gregg E Homanics; R Adron Harris
Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.
The Journal of pharmacology and experimental therapeutics 2012;340(2):317-29.
2012: Cecilia Borghese; Yuri A Blednov; Gregg E Homanics; Sangeetha V Iyer; David M Lovinger; S John Mihic; Yu Quan; James R Trudell; Wei Xiong; Li Zhang; R Adron Harris
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
The Journal of pharmacology and experimental therapeutics 2012;340(2):304-16.
2011: Vinuta Rau; James M Sonner; Christina Bodarky; Michael S Fanselow; Gregg E Homanics; Mark Liao; Irene Oh; Edmond I Eger
Gamma-aminobutyric acid type A receptor β3 subunit forebrain-specific knockout mice are resistant to the amnestic effect of isoflurane.
Anesthesia and analgesia 2011;113(3):500-4.
2011: Ki-Young Chang; Gregg E Homanics; Jeongjin Kim; Hye-Yeon Park; Young-Gyun Park; Daesoo Kim
Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor.
Biochemical and biophysical research communications 2011;410(1):19-23.
2011: R Adron Harris; E Osterndorff-Kahanek; Igor Ponomarev; Gregg E Homanics; Yuri A Blednov
Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.
Neuroscience letters 2011;488(1):31-5.
2011: Asha Suryanarayanan; Dev Chandra; Gregg E Homanics; Jing Liang; A Kerstin Lindemeyer; Edward M Meyer; Richard W Olsen; Werner Sieghart; Igor Spigelman
Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice.
Frontiers in neuroscience 2011;5():110.
2011: Sangeetha V Iyer; Harry L June; Sundari Rallapalli; Rodrigo A Benavides; Dev Chandra; James M Cook; Gregg E Homanics
α4-Containing GABA(A) Receptors are Required for Antagonism of Ethanol-Induced Motor Incoordination and Hypnosis by the Imidazobenzodiazepine Ro15-4513.
Frontiers in pharmacology 2011;2():18.
2011: Yuri A Blednov; Cecilia Borghese; M L McCracken; J M Benavidez; C R Geil; E Osterndorff-Kahanek; David F Werner; S Iyer; A Swihart; Neil L Harrison; Gregg E Homanics; R Adron Harris
Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.
The Journal of pharmacology and experimental therapeutics 2011;336(1):145-54.
2011: David F Werner; A Swihart; V Rau; F Jia; Cecilia Borghese; M L McCracken; S Iyer; Michael S Fanselow; I Oh; James M Sonner; Edmond I Eger; Neil L Harrison; R Adron Harris; Gregg E Homanics
Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.
The Journal of pharmacology and experimental therapeutics 2011;336(1):134-44.
2010: Adrian Handforth; Gregg E Homanics; Douglas F Covey; Kathiresan Krishnan; Jae Yeol Lee; Kenji Sakimura; Fredricka C Martin; Arnulfo Quesada
T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor.
Neuropharmacology 2010;59(6):380-7.
2010: M Lee Haselkorn; David K Shellington; Edwin K Jackson; Vincent A Vagni; Keri L Janesko-Feldman; Raghvendra K Dubey; Delbert G Gillespie; Dongmei Cheng; Michael J Bell; Larry W Jenkins; Gregg E Homanics; Jurgen Schnermann; Patrick M Kochanek
Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice.
Journal of neurotrauma 2010;27(5):901-10.
2010: Dev Chandra; Lauri M Halonen; Anni-Maija Linden; Chiara Procaccini; Kati Hellsten; Gregg E Homanics; Esa R Korpi
Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(4):999-1007.
2010: M D Moore; J Cushman; D Chandra; Gregg E Homanics; R W Olsen; Michael S Fanselow
Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptor.
Neurobiology of learning and memory 2010;93(3):383-7.
2010: Jennifer A Wilking; Kirstin G Hesterberg; Eric L Crouch; Gregg E Homanics; Jerry A Stitzel
Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity.
Pharmacogenetics and genomics 2010;20(2):121-30.
2010: Garilyn M Jentarra; Shannon L Olfers; Stephen G Rice; Nishit Srivastava; Gregg E Homanics; Mary E Blue; Sakkubai Naidu; Vinodh Narayanan
Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation.
BMC neuroscience 2010;11():19.
2009: Vinuta Rau; Sangeetha V Iyer; Irene Oh; Dev Chandra; Neil Harrison; Edmond I Eger; Michael S Fanselow; Gregg E Homanics; James M Sonner
Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isoflurane.
Anesthesia and analgesia 2009;109(6):1816-22.
2009: Harald Hentschke; Claudia Benkwitz; Matthew I Banks; Mark G Perkins; Gregg E Homanics; Robert A Pearce
Altered GABAA,slow inhibition and network oscillations in mice lacking the GABAA receptor beta3 subunit.
Journal of neurophysiology 2009;102(6):3643-55.
2009: Lauri M Halonen; Saku T Sinkkonen; Dev Chandra; Gregg E Homanics; Esa R Korpi
Brain regional distribution of GABA(A) receptors exhibiting atypical GABA agonism: roles of receptor subunits.
Neurochemistry international 2009;55(6):389-96.
2009: Haibiao Gong; Jinhan He; Jung Hoon Lee; Edward Mallick; Xiang Gao; Song Li; Gregg E Homanics; Wen Xie
Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury.
The Journal of biological chemistry 2009;284(44):30113-21.
2009: Kristen J Skvorak; Elizabeth J Hager; Erland Arning; Teodoro Bottiglieri; Harbhajan S Paul; Stephen C Strom; Gregg E Homanics; Qin Sun; Erwin E W Jansen; Cornelis Jakobs; William J Zinnanti; K Michael Gibson
Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).
Biochimica et biophysica acta 2009;1792(10):1004-10.
2009: Kristen J Skvorak; Harbhajan S Paul; K Dorko; Fabio Marongiu; Ewa Ellis; Donald Chace; Carolyn Ferguson; K Michael Gibson; Gregg E Homanics; Stephen C Strom
Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(7):1266-73.
2009: Raymond B Berry; Dev Chandra; Jaime L Diaz-Granados; Gregg E Homanics; Douglas B Matthews
Investigation of ethanol-induced impairment of spatial memory in gamma2 heterozygous knockout mice.
Neuroscience letters 2009;455(2):84-7.
2009: William J Zinnanti; Jelena Lazovic; Kathleen Griffin; Kristen J Skvorak; Harbhajan S Paul; Gregg E Homanics; Maria C Bewley; Keith C Cheng; Kathryn F Lanoue; John M Flanagan
Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.
Brain : a journal of neurology 2009;132(Pt 4):903-18.
2009: Murray B Herd; Nicola Foister; Dev Chandra; Dianne R Peden; Gregg E Homanics; Verity J Brown; David J K Balfour; Jeremy J Lambert; Delia Belelli
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors.
The European journal of neuroscience 2009;29(6):1177-87.
2009: David F Werner; Andrew R Swihart; Carolyn Ferguson; William R Lariviere; Neil L Harrison; Gregg E Homanics
Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive alpha1 GABA A receptors.
Alcoholism, clinical and experimental research 2009;33(2):289-99.
2009: Shui-Wang Ying; David F Werner; Gregg E Homanics; Neil L Harrison; Peter A Goldstein
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
Neuropharmacology 2009;56(2):438-47.
2009: Brian J Wiltgen; Bill P Godsil; Zechun Peng; Faysal Saab; Harry L June; Michael L Van Linn; James M Cook; Carolyn R Houser; Tom J O'Dell; Gregg E Homanics; Michael S Fanselow
The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala.
Frontiers in behavioral neuroscience 2009;3():37.
2008: Raymond B Berry; David F Werner; Xiaofei Wang; Monica M Jablonski; Gregg E Homanics; Guy Mittleman; Douglas B Matthews
Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks.
Neurobiology of learning and memory 2008;90(3):580-3.
2008: Fan Jia; Dev Chandra; Gregg E Homanics; Neil L Harrison
Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus.
The Journal of pharmacology and experimental therapeutics 2008;326(2):475-82.
2008: Timothy M DeLorey; Peyman Sahbaie; Ezzat Hashemi; Gregg E Homanics; J David Clark
Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder.
Behavioural brain research 2008;187(2):207-20.
2008: Fan Jia; Minerva Yue; Dev Chandra; Gregg E Homanics; Peter A Goldstein; Neil L Harrison
Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1127-35.
2008: Murray B Herd; Alison R Haythornthwaite; Thomas W Rosahl; Keith A Wafford; Gregg E Homanics; Jeremy J Lambert; Delia Belelli
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells.
The Journal of physiology 2008;586(4):989-1004.
2008: Dianne R Peden; Caroline M Petitjean; Murray B Herd; Murat S Durakoglugil; Thomas W Rosahl; Keith A Wafford; Gregg E Homanics; Delia Belelli; Jean-Marc Fritschy; Jeremy J Lambert
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.
The Journal of physiology 2008;586(4):965-87.
2008: Fan Jia; Minerva Yue; Dev Chandra; Angelo Keramidas; Peter A Goldstein; Gregg E Homanics; Neil L Harrison
Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(1):106-15.
2008: Dev Chandra; David F Werner; Jing Liang; Asha Suryanarayanan; Neil L Harrison; Igor Spigelman; Richard W Olsen; Gregg E Homanics
Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice.
Alcoholism, clinical and experimental research 2008;32(1):10-8.
2008: Jing Liang; Asha Suryanarayanan; Dev Chandra; Gregg E Homanics; Richard W Olsen; Igor Spigelman
Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells.
Alcoholism, clinical and experimental research 2008;32(1):19-26.
2007: JongBun Kim; Richard J Atherley; David F Werner; Gregg E Homanics; Earl Carstens; Joseph F Antognini
Isoflurane depression of spinal nociceptive processing and minimum alveolar anesthetic concentration are not attenuated in mice expressing isoflurane resistant gamma-aminobutyric acid type-A receptors.
Neuroscience letters 2007;420(3):209-12.
2007: David M Lovinger; Gregg E Homanics
Tonic for what ails us? high-affinity GABAA receptors and alcohol.
Alcohol (Fayetteville, N.Y.) 2007;41(3):139-43.
2007: Raphaëlle Winsky-Sommerer; Vladyslav V Vyazovskiy; Gregg E Homanics; Irene Tobler
The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors.
The European journal of neuroscience 2007;25(6):1893-9.
2007: Carolyn Ferguson; Steven L Hardy; David F Werner; Stanley M Hileman; Timothy M DeLorey; Gregg E Homanics
New insight into the role of the beta3 subunit of the GABAA-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout.
BMC neuroscience 2007;8():85.
2007: James M Sonner; David F Werner; Frank Peter Elsen; Yilei Xing; Mark Liao; R Adron Harris; Neil L Harrison; Michael S Fanselow; Edmond I Eger; Gregg E Homanics
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane.
Anesthesiology 2007;106(1):107-13.
2007: Joseph Glykys; Zechun Peng; Dev Chandra; Gregg E Homanics; Carolyn R Houser; Istvan Mody
A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol.
Nature neuroscience 2007;10(1):40-8.
2007: Harry L June; Katrina L Foster; William J A Eiler; Josuha Goergen; Jason B Cook; Nathan Johnson; Boikai Mensah-Zoe; Jothan O Simmons; Harry L June; Wenyuan Yin; James M Cook; Gregg E Homanics
Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(1):137-52.
2006: D Chandra; F Jia; Jing Liang; Zechun Peng; Asha Suryanarayanan; D F Werner; Igor Spigelman; Carolyn R Houser; Richard W Olsen; Neil L Harrison; Gregg E Homanics
GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15230-5.
2006: Stéphane F Maison; Thomas W Rosahl; Gregg E Homanics; M Charles Liberman
Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10315-26.
2006: Cecilia Borghese; David F Werner; Norbert Topf; N V Baron; Luke Henderson; Stephen L Boehm; Yuri A Blednov; A Saad; S Dai; R A Pearce; R Adron Harris; Gregg E Homanics; Neil L Harrison
An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.
The Journal of pharmacology and experimental therapeutics 2006;319(1):208-18.
2006: David F Werner; Yuri A Blednov; Olusegun J Ariwodola; Yuval Silberman; Exazevia Logan; Raymond B Berry; Cecilia Borghese; Douglas B Matthews; Jeff Weiner; Neil L Harrison; R Adron Harris; Gregg E Homanics
Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol.
The Journal of pharmacology and experimental therapeutics 2006;319(1):219-27.
2006: Stephen L Boehm; Gregg E Homanics; Yuri A Blednov; R Adron Harris
delta-Subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol.
European journal of pharmacology 2006;541(3):158-62.
2006: Kristen Skvorak; Bryce Vissel; Gregg E Homanics
Production of conditional point mutant knockin mice.
Genesis (New York, N.Y. : 2000) 2006;44(7):345-53.
2006: Sheryl S Smith; Yevgeniy Ruderman; Cheryl Frye; Gregg E Homanics; Maoli Yuan
Steroid withdrawal in the mouse results in anxiogenic effects of 3alpha,5beta-THP: a possible model of premenstrual dysphoric disorder.
Psychopharmacology 2006;186(3):323-33.
2006: Igor Ponomarev; Rajani Maiya; Mark T Harnett; Gwen L Schafer; Andrey E Ryabinin; Yuri A Blednov; Hitoshi Morikawa; Stephen L Boehm; Gregg E Homanics; Ari E Berman; Ari Berman; Kerrie H Lodowski; Susan E Bergeson; R Adron Harris
Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(21):5673-83.
2006: Jason E Kralic; Corinne Sidler; Franziska Parpan; Gregg E Homanics; A Leslie Morrow; Jean-Marc Fritschy
Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice.
The Journal of comparative neurology 2006;495(4):408-21.
2006: Patrick M Kochanek; Vincent A Vagni; Keri L Janesko; Christopher B Washington; Patricia K Crumrine; Robert H Garman; Larry W Jenkins; Robert S B Clark; Gregg E Homanics; C Edward Dixon; Jurgen Schnermann; Edwin K Jackson
Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(4):565-75.
2006: Frank Peter Elsen; Patricia Liljelund; David F Werner; Richard W Olsen; Gregg E Homanics; Neil L Harrison
GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice.
Brain research 2006;1078(1):60-70.
2006: Gregg E Homanics; Kristen Skvorak; Carolyn Ferguson; simon simon watkins; Harbhajan S Paul
Production and characterization of murine models of classic and intermediate maple syrup urine disease.
BMC medical genetics 2006;7():33.
2006: Waltraud Ogris; Reinhard Lehner; Karoline Fuchs; Birgit Furtmüller; Harald Höger; Gregg E Homanics; Werner Sieghart
Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice.
Journal of neurochemistry 2006;96(1):136-47.
2005: Adrian Handforth; Timothy M DeLorey; Gregg E Homanics; Richard W Olsen
Pharmacologic evidence for abnormal thalamocortical functioning in GABA receptor beta3 subunit-deficient mice, a model of Angelman syndrome.
Epilepsia 2005;46(12):1860-70.
2005: Patricia Liljelund; Carolyn Ferguson; Gregg E Homanics; Richard W Olsen
Long-term effects of diazepam treatment of epileptic GABAA receptor beta3 subunit knockout mouse in early life.
Epilepsy research 2005;66(1-3):99-115.
2005: James M Sonner; Mike Cascio; Yilei Xing; Michael S Fanselow; Jason E Kralic; A Leslie Morrow; Esa R Korpi; Steven Hardy; Brian Sloat; Edmond I Eger; Gregg E Homanics
Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear.
Molecular pharmacology 2005;68(1):61-8.
2005: Patricia Liljelund; Adrian Handforth; Gregg E Homanics; Richard W Olsen
GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior.
Brain research. Developmental brain research 2005;157(2):150-61.
2005: Brian J Wiltgen; Matthew J Sanders; Carolyn Ferguson; Gregg E Homanics; Michael S Fanselow
Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor.
Learning & memory (Cold Spring Harbor, N.Y.) 2005;12(3):327-33.
2005: Jason E Kralic; Hugh E Criswell; Jessica L Osterman; Todd O'Buckley; Mary E Wilkie; Douglas B Matthews; Kristin M Hamre; George R Breese; Gregg E Homanics; A Leslie Morrow
Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.
The Journal of clinical investigation 2005;115(3):774-9.
2005: Gregg E Homanics; Frank Peter Elsen; Shui-Wang Ying; Andrew Jenkins; C Ferguson; B Sloat; S Yuditskaya; Peter A Goldstein; Jason E Kralic; A Leslie Morrow; Neil L Harrison
A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse.
Genes, brain, and behavior 2005;4(1):10-9.
2005: Dev Chandra; Esa R Korpi; Celia P Miralles; Angel L De Blas; Gregg E Homanics
GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines.
BMC neuroscience 2005;6():30.
2004: Patrizia Panzanelli; Gregg E Homanics; Ole Petter Ottersen; Jean-Marc Fritschy; Marco Sassoè-Pognetto
Pre- and postsynaptic GABA receptors at reciprocal dendrodendritic synapses in the olfactory bulb.
The European journal of neuroscience 2004;20(11):2945-52.
2004: Erin E Shannon; Keith L Shelton; Jeffrey A Vivian; Ingrid Yount; Ashley R Morgan; Gregg E Homanics; Kathleen A Grant
Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunit.
Alcoholism, clinical and experimental research 2004;28(6):906-13.
2004: Mikko Uusi-Oukari; Paula Kosonen; Gregg E Homanics; Esa R Korpi
Brain regional heterogeneity of pH effects on GABA(A) receptor-associated [35s]TBPS binding.
Neurochemical research 2004;29(4):771-80.
2003: Geoffrey S Findlay; Rachel Phelan; Michael T Roberts; Gregg E Homanics; Susan E Bergeson; Greg Lopreato; S John Mihic; Yuri A Blednov; R Adron Harris
Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(22):8051-9.
2003: James M Sonner; Joseph F Antognini; Robert C Dutton; Pamela Flood; Andrew T Gray; R Adron Harris; Gregg E Homanics; Joan J Kendig; Beverley A Orser; Douglas Raines; Ira J Rampil; James R Trudell; Bryce Vissel; Edmond I Eger
Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
Anesthesia and analgesia 2003;97(3):718-40.
2003: Igor Spigelman; Zhiwei Li; Jing Liang; Elisabetta Cagetti; Sepideh Samzadeh; Robert M Mihalek; Gregg E Homanics; Richard W Olsen
Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit.
Journal of neurophysiology 2003;90(2):903-10.
2003: Jason E Kralic; Michael D Wheeler; K Renzi; C Ferguson; Todd O'Buckley; A Chistina Grobin; A Leslie Morrow; Gregg E Homanics
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
The Journal of pharmacology and experimental therapeutics 2003;305(2):600-7.
2003: Saku T Sinkkonen; Gregg E Homanics; Esa R Korpi
Mouse models of Angelman syndrome, a neurodevelopmental disorder, display different brain regional GABA(A) receptor alterations.
Neuroscience letters 2003;340(3):205-8.
2003: Darrell M Porcello; Molly M Huntsman; Robert M Mihalek; Gregg E Homanics; John R Huguenard
Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.
Journal of neurophysiology 2003;89(3):1378-86.
2003: Epolia Ramadan; Zhanyan Fu; Gabriele Losi; Gregg E Homanics; Joseph H Neale; Stefano Vicini
GABA(A) receptor beta3 subunit deletion decreases alpha2/3 subunits and IPSC duration.
Journal of neurophysiology 2003;89(1):128-34.
2002: Gregg E Homanics; Yan Xu; Pei Tang
Integrated approaches to the action of general anesthetics and alcohol.
Physiology & behavior 2002;77(4-5):495-9.
2002: Peter A Goldstein; Frank Peter Elsen; Shui-Wang Ying; Carolyn Ferguson; Gregg E Homanics; Neil L Harrison
Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit.
Journal of neurophysiology 2002;88(6):3208-17.
2002: Jonathan P Wisor; Timothy M DeLorey; Gregg E Homanics; Dale M Edgar
Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor.
Brain research 2002;955(1-2):221-8.
2002: Jason E Kralic; Todd O'Buckley; Rahul T Khisti; Clyde W Hodge; Gregg E Homanics; A Leslie Morrow
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Neuropharmacology 2002;43(4):685-94.
2002: Stefano Vicini; Gabriele Losi; Gregg E Homanics
GABA(A) receptor delta subunit deletion prevents neurosteroid modulation of inhibitory synaptic currents in cerebellar neurons.
Neuropharmacology 2002;43(4):646-50.
2002: Joseph J Quinlan; Carolyn Ferguson; Katherine Jester; Leonard L Firestone; Gregg E Homanics
Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics.
Anesthesia and analgesia 2002;95(3):578-82, table of contents.
2002: Jason E Kralic; Esa R Korpi; Todd O'Buckley; Gregg E Homanics; A Leslie Morrow
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1037-45.
2002: Ja-Won Koo; Gregg E Homanics; Carey D Balaban
Hypoplasia of spiral and Scarpa's ganglion cells in GABA(A) receptor beta(3) subunit knockout mice.
Hearing research 2002;167(1-2):71-80.
2002: Zechun Peng; Birgit Hauer; Robert M Mihalek; Gregg E Homanics; Werner Sieghart; Richard W Olsen; Carolyn R Houser
GABA(A) receptor changes in delta subunit-deficient mice: altered expression of alpha4 and gamma2 subunits in the forebrain.
The Journal of comparative neurology 2002;446(2):179-97.
2002: Igor Spigelman; Zhiwei Li; Pradeep K Banerjee; Robert M Mihalek; Gregg E Homanics; Richard W Olsen
Behavior and physiology of mice lacking the GABAA-receptor delta subunit.
Epilepsia 2002;43 Suppl 5():3-8.
2002: Esa R Korpi; Robert M Mihalek; Saku T Sinkkonen; Birgit Hauer; Wulf Hevers; Gregg E Homanics; Werner Sieghart; Hartmut Lüddens
Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits.
Neuroscience 2002;109(4):733-43.
2001: Robert M Mihalek; B J Bowers; Jeanne M Wehner; Jason E Kralic; Margaret VanDoren; A Leslie Morrow; Gregg E Homanics
GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol.
Alcoholism, clinical and experimental research 2001;25(12):1708-18.
2001: Zoltan Nusser; L M Kay; G Laurent; Gregg E Homanics; Istvan Mody
Disruption of GABA(A) receptors on GABAergic interneurons leads to increased oscillatory power in the olfactory bulb network.
Journal of neurophysiology 2001;86(6):2823-33.
2001: Shirley M E Wong; Gong Cheng; Gregg E Homanics; Joan J Kendig
Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor.
Anesthesiology 2001;95(1):154-64.
2001: S D Ugarte; Gregg E Homanics; Donna L Hammond
Effect of embryonic knock-down of GABAA receptors on the levels of monoamines and their metabolites in the CNS of the mouse.
Brain research 2001;904(2):290-7.
2001: Stefano Vicini; C Ferguson; Kate Prybylowski; Jason E Kralic; A Leslie Morrow; Gregg E Homanics
GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3009-16.
2001: Verena Tretter; Birgit Hauer; Zoltan Nusser; Robert M Mihalek; Harald Höger; Gregg E Homanics; P Somogyi; Werner Sieghart
Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells.
The Journal of biological chemistry 2001;276(13):10532-8.
2001: Saku T Sinkkonen; Robert M Mihalek; Gregg E Homanics; Hartmut Lüddens; Esa R Korpi
Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines.
Brain research. Molecular brain research 2001;86(1-2):179-83.
2000: Leonard L Firestone; Esa R Korpi; L Niemi; Per H Rosenberg; Gregg E Homanics; Joseph J Quinlan
Halothane and desflurane requirements in alcohol-tolerant and -nontolerant rats.
British journal of anaesthesia 2000;85(5):757-62.
2000: Mikko Uusi-Oukari; J Heikkilä; Saku T Sinkkonen; Rauno Mäkelä; Birgit Hauer; Gregg E Homanics; Werner Sieghart; william wisden; Esa R Korpi
Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster.
Molecular and cellular neurosciences 2000;16(1):34-41.
2000: Joseph J Quinlan; Leonard L Firestone; Gregg E Homanics
Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines.
Pharmacology, biochemistry, and behavior 2000;66(2):371-4.
2000: S D Ugarte; Gregg E Homanics; Leonard L Firestone; Donna L Hammond
Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor.
Neuroscience 2000;95(3):795-806.
1999: Robert M Mihalek; P K Banerjee; Esa R Korpi; Joseph J Quinlan; Leonard L Firestone; ZP Mi; Carl F Lagenaur; Verena Tretter; Werner Sieghart; Stephan Anagnostaras; J R Sage; Michael S Fanselow; Alessandro Guidotti; Igor Spigelman; Z Li; Timothy M DeLorey; Richard W Olsen; Gregg E Homanics
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12905-10.
1999: Gregg E Homanics; Joseph J Quinlan; Leonard L Firestone
Pharmacologic and behavioral responses of inbred C57BL/6J and strain 129/SvJ mouse lines.
Pharmacology, biochemistry, and behavior 1999;63(1):21-6.
1999: D R Schwartz; Gregg E Homanics; DG Hoyt; E Klein; John L Abernethy; John Lazo
The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(8):4680-5.
1999: Gregg E Homanics; Neil L Harrison; Joseph J Quinlan; Matthew D Krasowski; CE Rick; Angel L De Blas; Ashok K Mehta; F Kist; Robert M Mihalek; JJ Aul; Leonard L Firestone
Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor.
Neuropharmacology 1999;38(2):253-65.
1999: Molly M Huntsman; Darrell M Porcello; Gregg E Homanics; Timothy M DeLorey; John R Huguenard
Reciprocal inhibitory connections and network synchrony in the mammalian thalamus.
Science (New York, N.Y.) 1999;283(5401):541-3.
1998: Gregg E Homanics; Joseph J Quinlan; Robert M Mihalek; Leonard L Firestone
Genetic dissection of the molecular target(s) of anesthetics with the gene knockout approach in mice.
Toxicology letters 1998;100-101():301-7.
1998: Timothy M DeLorey; Adrian Handforth; Stephan Anagnostaras; Gregg E Homanics; Berge A Minassian; A Asatourian; Michael S Fanselow; Antonio V Delgado-Escueta; GD Ellison; Richard W Olsen
Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8505-14.
1998: Gregg E Homanics; Joseph J Quinlan; Robert M Mihalek; Leonard L Firestone
Alcohol and anesthetic mechanisms in genetically engineered mice.
Frontiers in bioscience : a journal and virtual library 1998;3():D548-58.
1998: Joseph J Quinlan; Gregg E Homanics; Leonard L Firestone
Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor.
Anesthesiology 1998;88(3):775-80.
1998: Gregg E Homanics; N Q Le; F Kist; Robert M Mihalek; A R Hart; Joseph J Quinlan
Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice.
Alcoholism, clinical and experimental research 1998;22(1):259-65.
1998: Matthew D Krasowski; CE Rick; Neil L Harrison; Leonard L Firestone; Gregg E Homanics
A deficit of functional GABA(A) receptors in neurons of beta 3 subunit knockout mice.
Neuroscience letters 1998;240(2):81-4.
1997: Rauno Mäkelä; Mikko Uusi-Oukari; Gregg E Homanics; Joseph J Quinlan; Leonard L Firestone; william wisden; Esa R Korpi
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
Molecular pharmacology 1997;52(3):380-8.
1997: Gregg E Homanics; Timothy M DeLorey; Leonard L Firestone; Joseph J Quinlan; Adrian Handforth; Neil L Harrison; Matthew D Krasowski; CE Rick; Esa R Korpi; Rauno Mäkelä; M H Brilliant; N Hagiwara; Carolyn Ferguson; K Snyder; Richard W Olsen
Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):4143-8.
1997: Gregg E Homanics; Carolyn Ferguson; Joseph J Quinlan; J Daggett; K Snyder; Carl F Lagenaur; ZP Mi; X H Wang; Dennis Grayson; Leonard L Firestone
Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics.
Molecular pharmacology 1997;51(4):588-96.
1997: Gregg E Homanics; S Hiller-Sturmhöfel
New genetic technologies in alcohol research.
Alcohol health and research world 1997;21(4):298-309.
1995: G M Mueller; L R McKenzie; Gregg E Homanics; simon simon watkins; Paul D Robbins; H S Paul
Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer.
Gene therapy 1995;2(7):461-8.