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Lin Hong

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Arun K Ghosh; Sarang Kulkarni; David D Anderson; Lin Hong; Abigail Baldridge; Yuan-Fang Wang; Alexander A Chumanevich; Andrey Yu Kovalevsky; Yasushi Tojo; Masayuki Amano; yasuhiro koh; Jordan Tang; Irene T Weber; Hiroaki Mitsuya
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.
Arun K Ghosh; Nagaswamy Kumaragurubaran; Lin Hong; Sarang Kulkarni; Xiaoming Xu; Heather B Miller; Dandepally Srinivasa Reddy; Vajira Weerasena; Robert Turner; Wanpin Chang; Gerald Koelsch; Jordan Tang
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.
Arun K Ghosh; Geoffrey Bilcer; Lin Hong; Gerald Koelsch; Jordan Tang
Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.

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All Publications

2009: Arun K Ghosh; Sarang Kulkarni; David D Anderson; Lin Hong; Abigail Baldridge; Yuan-Fang Wang; Alexander A Chumanevich; Andrey Yu Kovalevsky; Yasushi Tojo; Masayuki Amano; yasuhiro koh; Jordan Tang; Irene T Weber; Hiroaki Mitsuya
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.
Journal of medicinal chemistry 2009;52(23):7689-705.
2008: Arun K Ghosh; Nagaswamy Kumaragurubaran; Lin Hong; Sarang Kulkarni; Xiaoming Xu; Heather B Miller; Dandepally Srinivasa Reddy; Vajira Weerasena; Robert Turner; Wanpin Chang; Gerald Koelsch; Jordan Tang
Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.
Bioorganic & medicinal chemistry letters 2008;18(3):1031-6.
2007: Arun K Ghosh; Geoffrey Bilcer; Lin Hong; Gerald Koelsch; Jordan Tang
Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality.
Current Alzheimer research 2007;4(4):418-22.
2007: Arun K Ghosh; Nagaswamy Kumaragurubaran; Lin Hong; Sarang S Kulkarni; Xiaoming Xu; Wanpin Chang; Vajira Weerasena; Robert Turner; Gerald Koelsch; Geoffrey Bilcer; Jordan Tang
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Journal of medicinal chemistry 2007;50(10):2399-407.
2006: Arun K Ghosh; Nagaswamy Kumaragurubaran; Lin Hong; Hui Lei; Khaja Azhar Hussain; Chun-Feng Liu; Thippeswamy Devasamudram; Vajira Weerasena; Robert Turner; Gerald Koelsch; Geoffrey Bilcer; Jordan Tang
Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
Journal of the American Chemical Society 2006;128(16):5310-1.
2005: Jordan Tang; Xiangyang He; Xianping Huang; Lin Hong
Recent developments on the studies of human memapsin 2 (beta-secretase).
Current Alzheimer research 2005;2(2):261-4.
2005: Robert T Turner; Lin Hong; Gerald Koelsch; Arun K Ghosh; Jordan Tang
Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).
Biochemistry 2005;44(1):105-12.
2005: Arun K Ghosh; Thippeswamy Devasamudram; Lin Hong; Christopher DeZutter; Xiaoming Xu; Vajira Weerasena; Gerald Koelsch; Geoffrey Bilcer; Jordan Tang
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Bioorganic & medicinal chemistry letters 2005;15(1):15-20.
2004: Lin Hong; Xiangyuan He; Xiangping Huang; Wanpin Chang; Jordan Tang
Structural features of human memapsin 2 (beta-secretase) and their biological and pathological implications.
Acta biochimica et biophysica Sinica 2004;36(12):787-92.
2004: Lin Hong; Jordan Tang
Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis.
Biochemistry 2004;43(16):4689-95.
2003: Gerald Koelsch; Robert T Turner; Lin Hong; Arun K Ghosh; Jordan Tang
Memapsin 2, a drug target for Alzheimer's disease.
Biochemical Society symposium 2003;(70):213-20.
2003: Jordan Tang; Arun K Ghosh; Lin Hong; Gerald Koelsch; Robert T Turner; Wanpin Chang
Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.
Journal of molecular neuroscience : MN 2003;20(3):299-304.
2002: Lin Hong; Robert T Turner; Gerald Koelsch; Dongoo Shin; Arun K Ghosh; Jordan Tang
Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.
Biochemistry 2002;41(36):10963-7.
2002: Lin Hong; Robert T Turner; Gerald Koelsch; Arun K Ghosh; Jordan Tang
Memapsin 2 (beta-secretase) as a therapeutic target.
Biochemical Society transactions 2002;30(4):530-4.
2002: Arun K Ghosh; Lin Hong; Jordan Tang
Beta-secretase as a therapeutic target for inhibitor drugs.
Current medicinal chemistry 2002;9(11):1135-44.
2001: Arun K Ghosh; Geoffrey Bilcer; C Harwood; R Kawahama; D Shin; Khaja Azhar Hussain; Lin Hong; Jeffrey A Loy; C Nguyen; Gerald Koelsch; J Ermolieff; Jordan Tang
Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).
Journal of medicinal chemistry 2001;44(18):2865-8.
2001: Robert T Turner; Gerald Koelsch; Lin Hong; P Castanheira; J Ermolieff; Arun K Ghosh; Jordan Tang; P Castenheira; A Ghosh
Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.
Biochemistry 2001;40(34):10001-6.
2000: Lin Hong; Gerald Koelsch; Xinli Lin; Xinli Lin; Simon Terzyan; Arun K Ghosh; Xuejun C Zhang; Jordan Tang
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science (New York, N.Y.) 2000;290(5489):150-3.