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Tasuku Honjo

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Sabouri Zahra; Okazaki Il-Mi; Shinkura Reiko; Begum Nasim; Nagaoka Hitoshi; Tsuchimoto Daisuke; Nakabeppu Yusaku; Honjo Tasuku
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
Fujimoto Motoaki; Takagi Yasushi; Muraki Kazue; Nozaki Kazuhiko; Yamamoto Norio; Tsuji Masayuki; Hashimoto Nobuo; Honjo Tasuku; Tanigaki Kenji
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
Chikuma Shunsuke; Terawaki Seigo; Hayashi Tamon; Nabeshima Ryusuke; Yoshida Takao; Shibayama Shiro; Okazaki Taku; Honjo Tasuku
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.

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All Publications

2009: Sabouri Zahra; Okazaki Il-Mi; Shinkura Reiko; Begum Nasim; Nagaoka Hitoshi; Tsuchimoto Daisuke; Nakabeppu Yusaku; Honjo Tasuku
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
International immunology 2009;21(8):947-55.
2009: Fujimoto Motoaki; Takagi Yasushi; Muraki Kazue; Nozaki Kazuhiko; Yamamoto Norio; Tsuji Masayuki; Hashimoto Nobuo; Honjo Tasuku; Tanigaki Kenji
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
Developmental biology 2009;332(2):339-50.
2009: Chikuma Shunsuke; Terawaki Seigo; Hayashi Tamon; Nabeshima Ryusuke; Yoshida Takao; Shibayama Shiro; Okazaki Taku; Honjo Tasuku
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6682-9.
2009: Jiang Fang; Yoshida Taku; Nakaki Fumio; Terawaki Seigo; Chikuma Shunsuke; Kato Yu; Okazaki Il-Mi; Honjo Tasuku; Okazaki Taku
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
International immunology 2009;21(5):499-509.
2009: Shivarov Velizar; Shinkura Reiko; Doi Tomomitsu; Begum Nasim A; Nagaoka Hitoshi; Okazaki Il-Mi; Ito Satomi; Nonaka Taichiro; Kinoshita Kazuo; Honjo Tasuku
Molecular mechanism for generation of antibody memory.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):569-75.
2009: Doi Tomomitsu; Kato Lucia; Ito Satomi; Shinkura Reiko; Wei Min; Nagaoka Hitoshi; Wang Jishu; Honjo Tasuku
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2758-63.
2009: Begum Nasim A; Stanlie Andre; Doi Tomomitsu; Sasaki Yoko; Jin Hai Wei; Kim Yong Sung; Nagaoka Hitoshi; Honjo Tasuku
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2752-7.
2009: Nonaka Taichiro; Doi Tomomitsu; Toyoshima Takae; Muramatsu Masamichi; Honjo Tasuku; Kinoshita Kazuo
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2747-51.
2009: Takai A; Toyoshima T; Uemura M; Kitawaki Y; Marusawa H; Hiai H; Yamada S; Okazaki I M; Honjo T; Chiba T; Kinoshita K
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.
Oncogene 2009;28(4):469-78.
2008: Shivarov Velizar; Shinkura Reiko; Honjo Tasuku
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15866-71.
2008: Kido Masahiro; Watanabe Norihiko; Okazaki Taku; Akamatsu Takuji; Tanaka Junya; Saga Kazuyuki; Nishio Akiyoshi; Honjo Tasuku; Chiba Tsutomu
Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.
Gastroenterology 2008;135(4):1333-43.
2008: Endo Yoko; Marusawa Hiroyuki; Kou Tadayuki; Nakase Hiroshi; Fujii Shigehiko; Fujimori Takahiro; Kinoshita Kazuo; Honjo Tasuku; Chiba Tsutomu
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.
Gastroenterology 2008;135(3):889-98, 898.e1-3.
2008: Haspot Fabienne; Fehr Thomas; Gibbons Carrie; Zhao Guiling; Hogan Timothy; Honjo Tasuku; Freeman Gordon J; Sykes Megan
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.
Blood 2008;112(5):2149-55.
2008: Honjo Tasuku
A memoir of AID, which engraves antibody memory on DNA.
Nature immunology 2008;9(4):335-7.
2008: Riccio Orbicia; van Gijn Marielle E; Bezdek April C; Pellegrinet Luca; van Es Johan H; Zimber-Strobl Ursula; Strobl Lothar J; Honjo Tasuku; Clevers Hans; Radtke Freddy
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
EMBO reports 2008;9(4):377-83.
2008: Yoshida Taku; Jiang Fang; Honjo Tasuku; Okazaki Taku
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3533-8.
2007: Endo Y; Marusawa H; Kinoshita K; Morisawa T; Sakurai T; Okazaki I-M; Watashi K; Shimotohno K; Honjo T; Chiba T
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.
Oncogene 2007;26(38):5587-95.
2007: Terawaki Seigo; Tanaka Yoshimasa; Nagakura Tomokazu; Hayashi Tamon; Shibayama Shiro; Muroi Kaori; Okazaki Taku; Mikami Bunzo; Garboczi David N; Honjo Tasuku; Minato Nagahiro
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
International immunology 2007;19(7):881-90.
2007: Takebayashi Shinji; Yamamoto Norio; Yabe Daisuke; Fukuda Hitoshi; Kojima Ken; Ito Juichi; Honjo Tasuku
Multiple roles of Notch signaling in cochlear development.
Developmental biology 2007;307(1):165-78.
2007: Yabe Daisuke; Fukuda Hitoshi; Aoki Misayo; Yamada Shuichi; Takebayashi Shinji; Shinkura Reiko; Yamamoto Norio; Honjo Tasuku
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.
Genesis (New York, N.Y. : 2000) 2007;45(5):300-6.
2007: Matsumoto Yuko; Marusawa Hiroyuki; Kinoshita Kazuo; Endo Yoko; Kou Tadayuki; Morisawa Toshiyuki; Azuma Takeshi; Okazaki Il-Mi; Honjo Tasuku; Chiba Tsutomu
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
Nature medicine 2007;13(4):470-6.
2007: Hamanishi Junzo; Mandai Masaki; Iwasaki Masashi; Okazaki Taku; Tanaka Yoshimasa; Yamaguchi Ken; Higuchi Toshihiro; Yagi Haruhiko; Takakura Kenji; Minato Nagahiro; Honjo Tasuku; Fujii Shingo
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3360-5.
2007: Kotani Ai; Kakazu Naoki; Tsuruyama Tatsuaki; Okazaki Il-mi; Muramatsu Masamichi; Kinoshita Kazuo; Nagaoka Hitoshi; Yabe Daisuke; Honjo Tasuku
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1616-20.
2007: Tsuji Masayuki; Shinkura Reiko; Kuroda Kazuki; Yabe Daisuke; Honjo Tasuku
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1610-5.
2007: Begum Nasim A; Izumi Nakako; Nishikori Momoko; Nagaoka Hitoshi; Shinkura Reiko; Honjo Tasuku
Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.
The Journal of biological chemistry 2007;282(1):731-42.
2007: Okazaki Il-mi; Kotani Ai; Honjo Tasuku
Role of AID in tumorigenesis.
Advances in immunology 2007;94():245-73.
2007: Muramatsu Masamichi; Nagaoka Hitoshi; Shinkura Reiko; Begum Nasim A; Honjo Tasuku
Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.
Advances in immunology 2007;94():1-36.
2007: Shinkura Reiko; Okazaki Il-Mi; Muto Taro; Begum Nasim A; Honjo Tasuku
Regulation of AID function in vivo.
Advances in experimental medicine and biology 2007;596():71-81.
2006: Wang Jishu; Shinkura Reiko; Muramatsu Masamichi; Nagaoka Hitoshi; Kinoshita Kazuo; Honjo Tasuku
Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.
The Journal of biological chemistry 2006;281(28):19115-23.
2006: Tanaka Shinya; Tsukada Jun; Suzuki Wataru; Hayashi Katsuhiko; Tanigaki Kenji; Tsuji Masayuki; Inoue Hiromasa; Honjo Tasuku; Kubo Masato
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.
Immunity 2006;24(6):689-701.
2006: Ikuta Koichi; Kageyama Ryoichiro; Honjo Tasuku
The 20th IUBMB International Congress in Kyoto.
IUBMB life 2006;58(5-6):258.
2006: Okazaki Taku; Honjo Tasuku
The PD-1-PD-L pathway in immunological tolerance.
Trends in immunology 2006;27(4):195-201.
2006: Muto Taro; Okazaki Il-mi; Yamada Shuichi; Tanaka Yoshimasa; Kinoshita Kazuo; Muramatsu Masamichi; Nagaoka Hitoshi; Honjo Tasuku
Negative regulation of activation-induced cytidine deaminase in B cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2752-7.
2006: Okazaki Taku; Honjo Tasuku
Rejuvenating exhausted T cells during chronic viral infection.
Cell 2006;124(3):459-61.
2006: Fujikura Junji; Hosoda Kiminori; Iwakura Hiroshi; Tomita Tsutomu; Noguchi Michio; Masuzaki Hiroaki; Tanigaki Kenji; Yabe Daisuke; Honjo Tasuku; Nakao Kazuwa
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Cell metabolism 2006;3(1):59-65.
2006: Wakae Koshou; Magor Brad G; Saunders Holly; Nagaoka Hitoshi; Kawamura Akemi; Kinoshita Kazuo; Honjo Tasuku; Muramatsu Masamichi
Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.
International immunology 2006;18(1):41-7.
2006: Yamamoto Norio; Tanigaki Kenji; Tsuji Masayuki; Yabe Daisuke; Ito Juichi; Honjo Tasuku
Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.
Journal of molecular medicine (Berlin, Germany) 2006;84(1):37-45.
2005: Okazaki Taku; Otaka Yumi; Wang Jian; Hiai Hiroshi; Takai Toshiyuki; Ravetch Jeffrey V; Honjo Tasuku
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
The Journal of experimental medicine 2005;202(12):1643-8.
2005: Honjo Tasuku
Science and government. In search of the best grant system.
Science (New York, N.Y.) 2005;309(5739):1329.
2005: Wang Jian; Yoshida Taku; Nakaki Fumio; Hiai Hiroshi; Okazaki Taku; Honjo Tasuku
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11823-8.
2005: Honjo Tasuku; Nagaoka Hitoshi; Shinkura Reiko; Muramatsu Masamichi
AID to overcome the limitations of genomic information.
Nature immunology 2005;6(7):655-61.
2005: Okazaki Taku; Honjo Tasuku
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.
Trends in molecular medicine 2005;11(7):322-6.
2005: Kotani Ai; Okazaki Il-Mi; Muramatsu Masamichi; Kinoshita Kazuo; Begum Nasim A; Nakajima Toshiharu; Saito Hirohisa; Honjo Tasuku
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4506-11.
2005: Suzuki Keiichiro; Meek Bob; Doi Yasuko; Honjo Tasuku; Fagarasan Sidonia
Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2482-6.
2005: Nagaoka Hitoshi; Ito Satomi; Muramatsu Masamichi; Nakata Mikiyo; Honjo Tasuku
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2022-7.
2005: Kishi Yo; Takahashi Jun; Koyanagi Masaomi; Morizane Asuka; Okamoto Yo; Horiguchi Satoshi; Tashiro Kei; Honjo Tasuku; Fujii Shingo; Hashimoto Nobuo
Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells.
Journal of neuroscience research 2005;79(3):279-86.
2005: Iwai Yoshiko; Terawaki Seigo; Honjo Tasuku
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
International immunology 2005;17(2):133-44.
2004: Honjo Tasuku
Obituary: Yasutomi Nishizuka (1932-2004).
Nature 2004;432(7020):966.
2004: Nishida Akiko T; Kobuke Kazuhiro; Kojima Ken; Ito Juichi; Honjo Tasuku; Tashiro Kei
OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(4):766-74.
2004: Begum Nasim A; Kinoshita Kazuo; Kakazu Naoki; Muramatsu Masamichi; Nagaoka Hitoshi; Shinkura Reiko; Biniszkiewicz Detlev; Boyer Laurie A; Jaenisch Rudolf; Honjo Tasuku
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Science (New York, N.Y.) 2004;305(5687):1160-3.
2004: Begum Nasim A; Kinoshita Kazuo; Muramatsu Masamichi; Nagaoka Hitoshi; Shinkura Reiko; Honjo Tasuku
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13003-7.
2004: Shinkura Reiko; Ito Satomi; Begum Nasim A; Nagaoka Hitoshi; Muramatsu Masamichi; Kinoshita Kazuo; Sakakibara Yoshimasa; Hijikata Hiroko; Honjo Tasuku
Separate domains of AID are required for somatic hypermutation and class-switch recombination.
Nature immunology 2004;5(7):707-12.
2004: Honjo Tasuku; Muramatsu Masamichi; Fagarasan Sidonia
AID: how does it aid antibody diversity?
Immunity 2004;20(6):659-68.
2004: Fagarasan Sidonia; Honjo Tasuku
Regulation of IgA synthesis at mucosal surfaces.
Current opinion in immunology 2004;16(3):277-83.
2004: Tanigaki Kenji; Tsuji Masayuki; Yamamoto Norio; Han Hua; Tsukada Jun; Inoue Hiromasa; Kubo Masato; Honjo Tasuku
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.
Immunity 2004;20(5):611-22.
2004: Horiguchi Satoshi; Takahashi Jun; Kishi Yo; Morizane Asuka; Okamoto Yo; Koyanagi Masaomi; Tsuji Masayuki; Tashiro Kei; Honjo Tasuku; Fujii Shingo; Hashimoto Nobuo
Neural precursor cells derived from human embryonic brain retain regional specificity.
Journal of neuroscience research 2004;75(6):817-24.
2004: Ito Satomi; Nagaoka Hitoshi; Shinkura Reiko; Begum Nasim; Muramatsu Masamichi; Nakata Mikiyo; Honjo Tasuku
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1975-80.
2004: Suzuki Keiichiro; Meek Bob; Doi Yasuko; Muramatsu Masamichi; Chiba Tsutomu; Honjo Tasuku; Fagarasan Sidonia
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1981-6.
2003: Okazaki Taku; Tanaka Yoshimasa; Nishio Ryosuke; Mitsuiye Tamotsu; Mizoguchi Akira; Wang Jian; Ishida Masayoshi; Hiai Hiroshi; Matsumori Akira; Minato Nagahiro; Honjo Tasuku
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.
Nature medicine 2003;9(12):1477-83.
2003: Eto Tomonori; Kinoshita Kazuo; Yoshikawa Kiyotsugu; Muramatsu Masamichi; Honjo Tasuku
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12895-8.
2003: Ta Van-Thanh; Nagaoka Hitoshi; Catalan Nadia; Durandy Anne; Fischer Alain; Imai Kohsuke; Nonoyama Shigeaki; Tashiro Junko; Ikegawa Masaya; Ito Satomi; Kinoshita Kazuo; Muramatsu Masamichi; Honjo Tasuku
AID mutant analyses indicate requirement for class-switch-specific cofactors.
Nature immunology 2003;4(9):843-8.
2003: Toda Hiroki; Tsuji Masayuki; Nakano Ichiro; Kobuke Kazuhiro; Hayashi Takeshi; Kasahara Hironori; Takahashi Jun; Mizoguchi Akira; Houtani Takeshi; Sugimoto Tetsuo; Hashimoto Nobuo; Palmer Theo D; Honjo Tasuku; Tashiro Kei
Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.
The Journal of biological chemistry 2003;278(37):35491-500.
2003: Iwai Yoshiko; Terawaki Seigo; Ikegawa Masaya; Okazaki Taku; Honjo Tasuku
PD-1 inhibits antiviral immunity at the effector phase in the liver.
The Journal of experimental medicine 2003;198(1):39-50.
2003: Okazaki Il-mi; Hiai Hiroshi; Kakazu Naoki; Yamada Shuichi; Muramatsu Masamichi; Kinoshita Kazuo; Honjo Tasuku
Constitutive expression of AID leads to tumorigenesis.
The Journal of experimental medicine 2003;197(9):1173-81.
2003: Kanatsu-Shinohara Mito; Toyokuni Shinya; Morimoto Takeshi; Matsui Shigeyuki; Honjo Tasuku; Shinohara Takashi
Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.
Biology of reproduction 2003;68(5):1801-7.
2003: Okazaki Ilmi; Yoshikawa Kiyotsugu; Kinoshita Kazou; Muramatsu Masamichi; Nagaoka Hitoshi; Honjo Tasaku
Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation.
Annals of the New York Academy of Sciences 2003;987():1-8.
2003: Tanigaki Kenji; Kuroda Kazuki; Han Hua; Honjo Tasuku
Regulation of B cell development by Notch/RBP-J signaling.
Seminars in immunology 2003;15(2):113-9.
2003: Doi Tomomitsu; Kinoshita Kazuo; Ikegawa Masaya; Muramatsu Masamichi; Honjo Tasuku
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2634-8.
2003: Watanabe Norihiko; Ikuta Koichi; Okazaki Kazuichi; Nakase Hiroshi; Tabata Yasuhiko; Matsuura Minoru; Tamaki Hiroyuki; Kawanami Chiharu; Honjo Tasuku; Chiba Tsutomu
Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.
Digestive diseases and sciences 2003;48(2):408-14.
2003: Kuroda Kazuki; Han Hua; Tani Shoichi; Tanigaki Kenji; Tun Tin; Furukawa Takahisa; Taniguchi Yoshihito; Kurooka Hisanori; Hamada Yoshio; Toyokuni Shinya; Honjo Tasuku
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.
Immunity 2003;18(2):301-12.
2003: Yamamoto Norio; Tanigaki Kenji; Han Hua; Hiai Hiroshi; Honjo Tasuku
Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.
Current biology : CB 2003;13(4):333-8.
2003: Fagarasan Sidonia; Honjo Tasuku
Intestinal IgA synthesis: regulation of front-line body defences.
Nature reviews. Immunology 2003;3(1):63-72.
2003: Kanatsu-Shinohara Mito; Ogonuki Narumi; Inoue Kimiko; Ogura Atsuo; Toyokuni Shinya; Honjo Tasuku; Shinohara Takashi
Allogeneic offspring produced by male germ line stem cell transplantation into infertile mouse testis.
Biology of reproduction 2003;68(1):167-73.
2002: Shinohara T; Inoue K; Ogonuki N; Kanatsu-Shinohara M; Miki H; Nakata K; Kurome M; Nagashima H; Toyokuni S; Kogishi K; Honjo T; Ogura A
Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination.
Human reproduction (Oxford, England) 2002;17(12):3039-45.
2002: Okazaki Taku; Iwai Yoshiko; Honjo Tasuku
New regulatory co-receptors: inducible co-stimulator and PD-1.
Current opinion in immunology 2002;14(6):779-82.
2002: Fagarasan Sidonia; Muramatsu Masamichi; Suzuki Keiichiro; Nagaoka Hitoshi; Hiai Hiroshi; Honjo Tasuku
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.
Science (New York, N.Y.) 2002;298(5597):1424-7.
2002: Ishida Masayoshi; Iwai Yoshiko; Tanaka Yoshimasa; Okazaki Taku; Freeman Gordon J; Minato Nagahiro; Honjo Tasuku
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.
Immunology letters 2002;84(1):57-62.
2002: Iwai Yoshiko; Okazaki Taku; Nishimura Hiroyuki; Kawasaki Akemi; Yagita Hideo; Honjo Tasuku
Microanatomical localization of PD-1 in human tonsils.
Immunology letters 2002;83(3):215-20.
2002: Iwai Yoshiko; Ishida Masayoshi; Tanaka Yoshimasa; Okazaki Taku; Honjo Tasuku; Minato Nagahiro
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12293-7.
2002: Watanabe Norihiko; Ikuta Koichi; Nisitani Sazuku; Chiba Tsutomu; Honjo Tasuku
Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice.
The Journal of experimental medicine 2002;196(1):141-6.
2002: Yoshikawa Kiyotsugu; Okazaki Il-Mi; Eto Tomonori; Kinoshita Kazuo; Muramatsu Masamichi; Nagaoka Hitoshi; Honjo Tasuku
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.
Science (New York, N.Y.) 2002;296(5575):2033-6.
2002: Han Hua; Tanigaki Kenji; Yamamoto Norio; Kuroda Kazuki; Yoshimoto Momoko; Nakahata Tatsutoshi; Ikuta Koichi; Honjo Tasuku
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
International immunology 2002;14(6):637-45.
2002: Tanigaki Kenji; Han Hua; Yamamoto Norio; Tashiro Kei; Ikegawa Masaya; Kuroda Kazuki; Suzuki Akira; Nakano Toru; Honjo Tasuku
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Nature immunology 2002;3(5):443-50.
2002: Taniguchi Yoshihito; Karlström Helena; Lundkvist Johan; Mizutani Tomohiko; Otaka Akira; Vestling Monica; Bernstein Alan; Donoviel Dorit; Lendahl Urban; Honjo Tasuku
Notch receptor cleavage depends on but is not directly executed by presenilins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):4014-9.
2002: Okazaki Il-mi; Kinoshita Kazuo; Muramatsu Masamichi; Yoshikawa Kiyotsugu; Honjo Tasuku
The AID enzyme induces class switch recombination in fibroblasts.
Nature 2002;416(6878):340-5.
2002: Nagaoka Hitoshi; Muramatsu Masamichi; Yamamura Namiko; Kinoshita Kazuo; Honjo Tasuku
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.
The Journal of experimental medicine 2002;195(4):529-34.
2002: Kanatsu-Shinohara Mito; Ogura Atsuo; Ikegawa Masaya; Inoue Kimiko; Ogonuki Narumi; Tashiro Kei; Toyokuni Shinya; Honjo Tasuku; Shinohara Takashi
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1383-8.
2002: Honjo Tasuku; Kinoshita Kazuo; Muramatsu Masamichi
Molecular mechanism of class switch recombination: linkage with somatic hypermutation.
Annual review of immunology 2002;20():165-96.
2001: Ye S K; Agata Y; Lee H C; Kurooka H; Kitamura T; Shimizu A; Honjo T; Ikuta K
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation.
Immunity 2001;15(5):813-23.
2001: Chen X; Kinoshita K; Honjo T
Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13860-5.
2001: Okazaki T; Maeda A; Nishimura H; Kurosaki T; Honjo T
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13866-71.
2001: Fagarasan S; Kinoshita K; Muramatsu M; Ikuta K; Honjo T
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.
Nature 2001;413(6856):639-43.
2001: Kinoshita K; Harigai M; Fagarasan S; Muramatsu M; Honjo T
A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12620-3.
2001: Durandy A; Honjo T
Human genetic defects in class-switch recombination (hyper-IgM syndromes).
Current opinion in immunology 2001;13(5):543-8.
2001: Kobuke K; Furukawa Y; Sugai M; Tanigaki K; Ohashi N; Matsumori A; Sasayama S; Honjo T; Tashiro K
ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury.
The Journal of biological chemistry 2001;276(36):34105-14.
2001: Ye S K; Maki K; Lee H C; Ito A; Kawai K; Suzuki H; Mak T W; Chien Y; Honjo T; Ikuta K
Differential roles of cytokine receptors in the development of epidermal gamma delta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1929-34.
2001: Lee C G; Kinoshita K; Arudchandran A; Cerritelli S M; Crouch R J; Honjo T
Quantitative regulation of class switch recombination by switch region transcription.
The Journal of experimental medicine 2001;194(3):365-74.
2001: Mizutani T; Taniguchi Y; Aoki T; Hashimoto N; Honjo T
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9026-31.
2001: Kinoshita K; Honjo T
Linking class-switch recombination with somatic hypermutation.
Nature reviews. Molecular cell biology 2001;2(7):493-503.
2001: Lee H C; Ye S K; Honjo T; Ikuta K
Induction of germline transcription in the human TCR gamma locus by STAT5.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):320-6.
2001: Ikegawa M; Yuan J; Matsumoto K; Herrmann S; Iwamoto A; Nakamura T; Matsushita S; Kimura T; Honjo T; Tashiro K
Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS.
AIDS research and human retroviruses 2001;17(7):587-95.
2001: Nishimura H; Honjo T
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.
Trends in immunology 2001;22(5):265-8.
2001: Agata Y; Katakai T; Ye S K; Sugai M; Gonda H; Honjo T; Ikuta K; Shimizu A
Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination.
The Journal of experimental medicine 2001;193(7):873-80.
2001: Tashiro J; Kinoshita K; Honjo T
Palindromic but not G-rich sequences are targets of class switch recombination.
International immunology 2001;13(4):495-505.
2001: Tani S; Kurooka H; Aoki T; Hashimoto N; Honjo T
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.
Nucleic acids research 2001;29(6):1373-80.
2001: Nishimura H; Okazaki T; Tanaka Y; Nakatani K; Hara M; Matsumori A; Sasayama S; Mizoguchi A; Hiai H; Minato N; Honjo T
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
Science (New York, N.Y.) 2001;291(5502):319-22.
2001: Tanigaki K; Nogaki F; Takahashi J; Tashiro K; Kurooka H; Honjo T
Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.
Neuron 2001;29(1):45-55.
2000: Watanabe N; Ikuta K; Fagarasan S; Yazumi S; Chiba T; Honjo T
Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice.
The Journal of experimental medicine 2000;192(11):1577-86.
2000: Fagarasan S; Honjo T
T-Independent immune response: new aspects of B cell biology.
Science (New York, N.Y.) 2000;290(5489):89-92.
2000: Yanagawa S; Lee J S; Kakimi K; Matsuda Y; Honjo T; Ishimoto A
Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus.
Journal of virology 2000;74(20):9786-91.
2000: Revy P; Muto T; Levy Y; Geissmann F; Plebani A; Sanal O; Catalan N; Forveille M; Dufourcq-Labelouse R; Gennery A; Tezcan I; Ersoy F; Kayserili H; Ugazio A G; Brousse N; Muramatsu M; Notarangelo L D; Kinoshita K; Honjo T; Fischer A; Durandy A
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Cell 2000;102(5):565-75.
2000: Muramatsu M; Kinoshita K; Fagarasan S; Yamada S; Shinkai Y; Honjo T
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Cell 2000;102(5):553-63.
2000: Fagarasan S; Watanabe N; Honjo T
Generation, expansion, migration and activation of mouse B1 cells.
Immunological reviews 2000;176():205-15.
2000: Muto T; Muramatsu M; Taniwaki M; Kinoshita K; Honjo T
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
Genomics 2000;68(1):85-8.
2000: Kamata T; Nogaki F; Fagarasan S; Sakiyama T; Kobayashi I; Miyawaki S; Ikuta K; Muso E; Yoshida H; Sasayama S; Honjo T
Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1387-94.
2000: Kurooka H; Honjo T
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.
The Journal of biological chemistry 2000;275(22):17211-20.
2000: Fagarasan S; Shinkura R; Kamata T; Nogaki F; Ikuta K; Tashiro K; Honjo T
Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system.
The Journal of experimental medicine 2000;191(9):1477-86.
2000: Kinoshita K; Honjo T
Unique and unprecedented recombination mechanisms in class switching.
Current opinion in immunology 2000;12(2):195-8.
2000: Nishimura H; Honjo T; Minato N
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.
The Journal of experimental medicine 2000;191(5):891-8.
2000: Fagarasan S; Shinkura R; Kamata T; Nogaki F; Ikuta K; Honjo T
Mechanism of B1 cell differentiation and migration in GALT.
Current topics in microbiology and immunology 2000;252():221-9.
1999: Minoguchi S; Ikeda T; Itohara S; Kaneko T; Okaichi H; Honjo T
Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion of beta-galactosidase.
Journal of biochemistry 1999;126(4):738-47.
1999: Ye S K; Maki K; Kitamura T; Sunaga S; Akashi K; Domen J; Weissman I L; Honjo T; Ikuta K
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.
Immunity 1999;11(2):213-23.
1999: Nishimura H; Nose M; Hiai H; Minato N; Honjo T
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Immunity 1999;11(2):141-51.
1999: Watanabe N; Nisitani S; Ikuta K; Suzuki M; Chiba T; Honjo T
Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment.
The Journal of experimental medicine 1999;190(4):461-69.
1999: Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon N L; Schaub R; Matsumori A; Sasayama S; Chien K R; Honjo T
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.
The Journal of biological chemistry 1999;274(32):22476-83.
1999: Lee J S; Ishimoto A; Honjo T; Yanagawa S
Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3.
FEBS letters 1999;455(3):276-80.
1999: Kanazawa N; Nakamura T; Tashiro K; Muramatsu M; Morita K; Yoneda K; Inaba K; Imamura S; Honjo T
Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.
European journal of immunology 1999;29(6):1925-32.
1999: Muramatsu M; Sankaranand V S; Anant S; Sugai M; Kinoshita K; Davidson N O; Honjo T
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
The Journal of biological chemistry 1999;274(26):18470-6.
1999: Sakiyama T; Ikuta K; Nisitani S; Takatsu K; Honjo T
Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice.
International immunology 1999;11(6):995-1000.
1999: Lee J S; Haruna T; Ishimoto A; Honjo T; Yanagawa S
Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events.
Journal of virology 1999;73(6):5166-71.
1999: Shinkura R; Kitada K; Matsuda F; Tashiro K; Ikuta K; Suzuki M; Kogishi K; Serikawa T; Honjo T
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase.
Nature genetics 1999;22(1):74-7.
1999: Tashiro K; Ikegawa M; Yabe D; Honjo T
[Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants]
Nippon rinsho. Japanese journal of clinical medicine 1999;57(4):967-74.
1999: Kuroda K; Tani S; Tamura K; Minoguchi S; Kurooka H; Honjo T
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis.
The Journal of biological chemistry 1999;274(11):7238-44.
1999: Kinoshita K; Lee C G; Tashiro J; Muramatsu M; Chen X C; Yoshikawa K; Honjo T
Molecular mechanism of immunoglobulin class switch recombination.
Cold Spring Harbor symposia on quantitative biology 1999;64():217-26.
1999: Nisitani S; Honjo T
Breakage of B cell tolerance and autoantibody production in anti-erythrocyte transgenic mice.
International reviews of immunology 1999;18(3):259-70.
1999: Tani S; Taniwaki M; Taniguchi Y; Minoguchi S; Kuroda K; Han H; Aoki T; Miyatake S; Hashimoto N; Honjo T
Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L.
Journal of human genetics 1999;44(1):73-5.
1998: Kinoshita K; Tashiro J; Tomita S; Lee C G; Honjo T
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.
Immunity 1998;9(6):849-58.
1998: Hoshiyama D; Suga H; Iwabe N; Koyanagi M; Nikoh N; Kuma K; Matsuda F; Honjo T; Miyata T
Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family.
Journal of molecular evolution 1998;47(6):640-8.
1998: Matsuda F; Ishii K; Bourvagnet P; Kuma K i; Hayashida H; Miyata T; Honjo T
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.
The Journal of experimental medicine 1998;188(11):2151-62.
1998: Kurooka H; Kuroda K; Honjo T
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.
Nucleic acids research 1998;26(23):5448-55.
1998: Nakamura T; Yabe D; Kanazawa N; Tashiro K; Sasayama S; Honjo T
Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability.
Genomics 1998;54(1):89-98.
1998: Nishimura H; Minato N; Nakano T; Honjo T
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
International immunology 1998;10(10):1563-72.
1998: Nisitani S; Sakiyama T; Honjo T
Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice.
International immunology 1998;10(8):1039-47.
1998: Sakai T; Taniguchi Y; Tamura K; Minoguchi S; Fukuhara T; Strobl L J; Zimber-Strobl U; Bornkamm G W; Honjo T
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.
Journal of virology 1998;72(7):6034-9.
1998: Watanabe N; Nomura T; Takai T; Chiba T; Honjo T; Tsubata T
Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells.
Scandinavian journal of immunology 1998;47(6):541-7.
1998: Yabe D; Taniwaki M; Nakamura T; Kanazawa N; Tashiro K; Honjo T
Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.
Genomics 1998;49(2):331-3.
1998: Lee C G; Kondo S; Honjo T
Frequent but biased class switch recombination in the S mu flanking regions.
Current biology : CB 1998;8(4):227-30.
1998: Sugai M; Kondo S; Shimizu A; Honjo T
Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase.
Nucleic acids research 1998;26(4):911-8.
1998: Taniguchi Y; Furukawa T; Tun T; Han H; Honjo T
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein.
Molecular and cellular biology 1998;18(1):644-54.
1997: Murakami M; Honjo T
Transgenic mouse models for B-cell dominant autoimmune diseases.
Current opinion in immunology 1997;9(6):846-50.
1997: Nisitani S; Murakami M; Akamizu T; Okino T; Ohmori K; Mori T; Imamura M; Honjo T
Preferential localization of human CD5+ B cells in the peritoneal cavity.
Scandinavian journal of immunology 1997;46(6):541-5.
1997: Kato H; Taniguchi Y; Kurooka H; Minoguchi S; Sakai T; Nomura-Okazaki S; Tamura K; Honjo T
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.
Development (Cambridge, England) 1997;124(20):4133-41.
1997: Yamamoto M; Honjo T; Paumen M B
[Fatty acids-induced apoptosis]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1637-43.
1997: Yabe D; Nakamura T; Kanazawa N; Tashiro K; Honjo T
Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.
The Journal of biological chemistry 1997;272(29):18232-9.
1997: Aoki T; Koike T; Nakano T; Shibahara K; Nishimura H; Kikuchi H; Honjo T
Rat TAFII31 gene is induced upon programmed cell death in differentiated PC12 cells deprived of NGF.
Biochemical and biophysical research communications 1997;234(1):230-4.
1997: Minoguchi S; Taniguchi Y; Kato H; Okazaki T; Strobl L J; Zimber-Strobl U; Bornkamm G W; Honjo T
RBP-L, a transcription factor related to RBP-Jkappa.
Molecular and cellular biology 1997;17(5):2679-87.
1997: Han H; Nomura T; Honjo T; Tsubata T
Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():367-9.
1997: Nisitani S; Murakami M; Honjo T
Anti-red blood cell immunoglobulin transgenic mice. An experimental model of autoimmune hemolytic anemia.
Annals of the New York Academy of Sciences 1997;815():246-52.
1997: Kurooka H; Kato K; Minoguchi S; Takahashi Y; Ikeda J; Habu S; Osawa N; Buchberg A M; Moriwaki K; Shisa H; Honjo T
Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin.
Genomics 1997;39(3):331-9.
1997: Paumen M B; Ishida Y; Han H; Muramatsu M; Eguchi Y; Tsujimoto Y; Honjo T
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2.
Biochemical and biophysical research communications 1997;231(3):523-5.
1997: Shinohara T; Honjo T
Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus.
European journal of immunology 1997;27(2):522-9.
1997: Murakami M; Nakajima K; Yamazaki K; Muraguchi T; Serikawa T; Honjo T
Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice.
The Journal of experimental medicine 1997;185(4):791-4.
1997: Paumen M B; Ishida Y; Muramatsu M; Yamamoto M; Honjo T
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.
The Journal of biological chemistry 1997;272(6):3324-9.
1997: Aoki T; Koike T; Nakano T; Shibahara K; Kondo S; Kikuchi H; Honjo T
Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons.
Journal of biochemistry 1997;121(1):122-7.
1996: Shirozu M; Tada H; Tashiro K; Nakamura T; Lopez N D; Nazarea M; Hamada T; Sato T; Nakano T; Honjo T
Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.
Genomics 1996;37(3):273-80.
1996: Tsubata R; Tsubata T; Hiai H; Shinkura R; Matsumura R; Sumida T; Miyawaki S; Ishida H; Kumagai S; Nakao K; Honjo T
Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjögren's syndrome.
European journal of immunology 1996;26(11):2742-8.
1996: Hamada T; Tashiro K; Tada H; Inazawa J; Shirozu M; Shibahara K; Nakamura T; Martina N; Nakano T; Honjo T
Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.
Gene 1996;176(1-2):211-4.
1996: Han H; Nomura T; Honjo T; Tsubata T
Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40.
European journal of immunology 1996;26(10):2425-32.
1996: Kato H; Sakai T; Tamura K; Minoguchi S; Shirayoshi Y; Hamada Y; Tsujimoto Y; Honjo T
Functional conservation of mouse Notch receptor family members.
FEBS letters 1996;395(2-3):221-4.
1996: Akamizu T; Matsuda F; Okuda J; Li H; Kanda H; Watanabe T; Honjo T; Mori T
Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3148-52.
1996: Shinkura R; Matsuda F; Sakiyama T; Tsubata T; Hiai H; Paumen M; Miyawaki S; Honjo T
Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice.
International immunology 1996;8(7):1067-75.
1996: Kurooka H; Segre J A; Hirano Y; Nemhauser J L; Nishimura H; Yoneda K; Lander E S; Honjo T
Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus.
International immunology 1996;8(6):961-6.
1996: Nomura T; Han H; Howard M C; Yagita H; Yakura H; Honjo T; Tsubata T
Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice.
International immunology 1996;8(6):867-75.
1996: Nishimura H; Agata Y; Kawasaki A; Sato M; Imamura S; Minato N; Yagita H; Nakano T; Honjo T
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes.
International immunology 1996;8(5):773-80.
1996: Agata Y; Kawasaki A; Nishimura H; Ishida Y; Tsubata T; Yagita H; Honjo T
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
International immunology 1996;8(5):765-72.
1996: Nakano T; Kodama H; Honjo T
In vitro development of primitive and definitive erythrocytes from different precursors.
Science (New York, N.Y.) 1996;272(5262):722-4.
1996: Shinohara T; Honjo T
Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro.
European journal of immunology 1996;26(4):747-52.
1996: Murakami M; Honjo T
Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia.
Seminars in immunology 1996;8(1):3-9.
1996: Nakamura M; Kondo S; Sugai M; Nazarea M; Imamura S; Honjo T
High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.
International immunology 1996;8(2):193-201.
1996: Honjo T
The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):1-9.
1996: Matsuda F; Honjo T
Organization of the human immunoglobulin heavy-chain locus.
Advances in immunology 1996;62():1-29.
1995: Tamura K; Taniguchi Y; Minoguchi S; Sakai T; Tun T; Furukawa T; Honjo T
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
Current biology : CB 1995;5(12):1416-23.
1995: Shibahara K; Asano M; Ishida Y; Aoki T; Koike T; Honjo T
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
Gene 1995;166(2):297-301.
1995: Nakamura T; Tashiro K; Nazarea M; Nakano T; Sasayama S; Honjo T
The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.
Genomics 1995;30(2):312-9.
1995: Nisitani S; Tsubata T; Murakami M; Honjo T
Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice.
European journal of immunology 1995;25(11):3047-52.
1995: Oka C; Nakano T; Wakeham A; de la Pompa J L; Mori C; Sakai T; Okazaki S; Kawaichi M; Shiota K; Mak T W; Honjo T
Disruption of the mouse RBP-J kappa gene results in early embryonic death.
Development (Cambridge, England) 1995;121(10):3291-301.
1995: Sakai T; Furukawa T; Iwanari H; Oka C; Nakano T; Kawaichi M; Honjo T
Loss of immunostaining of the RBP-J kappa transcription factor upon F9 cell differentiation induced by retinoic acid.
Journal of biochemistry 1995;118(3):621-8.
1995: Murakami M; Honjo T
B-1 cells and autoimmunity.
Annals of the New York Academy of Sciences 1995;764():402-9.
1995: Furukawa T; Kobayakawa Y; Tamura K; Kimura K; Kawaichi M; Tanimura T; Honjo T
Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8.
Idengaku zasshi 1995;70(4):505-24.
1995: Shirozu M; Nakano T; Inazawa J; Tashiro K; Tada H; Shinohara T; Honjo T
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene.
Genomics 1995;28(3):495-500.
1995: Murakami M; Yoshioka H; Shirai T; Tsubata T; Honjo T
Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells.
International immunology 1995;7(5):877-82.
1994: Asano M; Ishida Y; Sabe H; Kondo M; Sugamura K; Honjo T
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5373-81.
1994: Furukawa T; Kimura K; Kobayakawa Y; Tamura K; Kawaichi M; Tanimura T; Honjo T
Genetic characterization of Drosophila RBP-J kappa (suppressor of hairless) as a neurogenic gene in adult PNS development.
Idengaku zasshi 1994;69(6):701-11.
1994: Shinohara T; Taniwaki M; Ishida Y; Kawaichi M; Honjo T
Structure and chromosomal localization of the human PD-1 gene (PDCD1).
Genomics 1994;23(3):704-6.
1994: Nakano T; Kodama H; Honjo T
Generation of lymphohematopoietic cells from embryonic stem cells in culture.
Science (New York, N.Y.) 1994;265(5175):1098-101.
1994: Chung C N; Hamaguchi Y; Honjo T; Kawaichi M
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa.
Nucleic acids research 1994;22(15):2938-44.
1994: Tsubata T; Murakami M; Nisitani S; Honjo T
Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1313):297-301.
1994: Murakami M; Tsubata T; Shinkura R; Nisitani S; Okamoto M; Yoshioka H; Usui T; Miyawaki S; Honjo T
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.
The Journal of experimental medicine 1994;180(1):111-21.
1994: Nisitani S; Tsubata T; Honjo T
Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo.
International immunology 1994;6(6):909-16.
1994: Tun T; Hamaguchi Y; Matsunami N; Furukawa T; Honjo T; Kawaichi M
Recognition sequence of a highly conserved DNA binding protein RBP-J kappa.
Nucleic acids research 1994;22(6):965-71.
1994: Shin E K; Akamizu T; Matsuda F; Sugawa H; Fujikura J; Mori T; Honjo T
Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1485-92.
1994: Iwasato T; Kanari Y; Shimizu A; Honjo T; Yamagishi H
Transforming growth factor-beta induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation.
Immunology letters 1994;39(2):173-8.
1994: Matsumura R; Matsuda F; Nagaoka H; Fujikura J; Shin E K; Fukita Y; Haino M; Honjo T
Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes. Evidence for recent reshuffling.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):660-6.
1994: Tsubata T; Murakami M; Honjo T
Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice.
Current biology : CB 1994;4(1):8-17.
1993: Nisitani S; Tsubata T; Murakami M; Okamoto M; Honjo T
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.
The Journal of experimental medicine 1993;178(4):1247-54.
1993: Saito Y; Nazarea M; Honjo T
Pseudo-high-affinity IL-2 receptor and growth signal transduction in lymphocytes.
International immunology 1993;5(10):1211-7.
1993: Shin E K; Matsuda F; Fujikura J; Akamizu T; Sugawa H; Mori T; Honjo T
Cloning of a human immunoglobulin gene fragment containing both VH-D and D-JH rearrangements: implication for VH-D as an intermediate to VH-D-JH formation.
European journal of immunology 1993;23(9):2365-7.
1993: Amakawa R; Jing W; Ozawa K; Matsunami N; Hamaguchi Y; Matsuda F; Kawaichi M; Honjo T
Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.
Genomics 1993;17(2):306-15.
1993: Fukita Y; Mizuta T R; Shirozu M; Ozawa K; Shimizu A; Honjo T
The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region.
The Journal of biological chemistry 1993;268(23):17463-70.
1993: Tsubata T; Wu J; Honjo T
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40.
Nature 1993;364(6438):645-8.
1993: Tashiro K; Tada H; Heilker R; Shirozu M; Nakano T; Honjo T
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins.
Science (New York, N.Y.) 1993;261(5121):600-3.
1993: Shimada M O; Yamada Y; Nakakuki Y; Okamoto K; Fukumoto M; Honjo T; Hiai H
SL/KH strain of mice: a model of spontaneous pre-B-lymphomas.
Leukemia research 1993;17(7):573-8.
1993: Mizuta T R; Fukita Y; Miyoshi T; Shimizu A; Honjo T
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences.
Nucleic acids research 1993;21(8):1761-6.
1993: Arakawa H; Iwasato T; Hayashida H; Shimizu A; Honjo T; Yamagishi H
The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.
The Journal of biological chemistry 1993;268(7):4651-5.
1993: Shimizu A; Honjo T
Synthesis and regulation of trans-mRNA encoding the immunoglobulin epsilon heavy chain.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(1):149-54.
1993: Shin E K; Matsuda F; Ozaki S; Kumagai S; Olerup O; Ström H; Melchers I; Honjo T
Polymorphism of the human immunoglobulin variable region segment V1-4.1.
Immunogenetics 1993;38(4):304-6.
1993: Nazarea M; Saito Y; Okazaki S; Suzuki N; Honjo T
A monoclonal antibody which inhibits growth of T cell lines.
Growth factors (Chur, Switzerland) 1993;9(2):139-47.
1992: Ishida Y; Agata Y; Shibahara K; Honjo T
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
The EMBO journal 1992;11(11):3887-95.
1992: Honjo T
Seppuku and autoimmunity.
Science (New York, N.Y.) 1992;258(5082):591-2.
1992: Hamaguchi Y; Yamamoto Y; Iwanari H; Maruyama S; Furukawa T; Matsunami N; Honjo T
Biochemical and immunological characterization of the DNA binding protein (RBP-J kappa) to mouse J kappa recombination signal sequence.
Journal of biochemistry 1992;112(3):314-20.
1992: Miwa H; Kita K; Nosaka T; Ikeda T; Kawakami K; Anazawa H; Hoshino K; Ohno T; Honjo T; Hatanaka M
Maturational stage specific immunoglobulin heavy chain gene rearrangements, determined by D and D upstream region gene structures.
Leukemia research 1992;16(9):861-71.
1992: Furukawa T; Maruyama S; Kawaichi M; Honjo T
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.
Cell 1992;69(7):1191-7.
1992: Iwasato T; Arakawa H; Shimizu A; Honjo T; Yamagishi H
Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.
The Journal of experimental medicine 1992;175(6):1539-46.
1992: Murakami M; Tsubata T; Okamoto M; Shimizu A; Kumagai S; Imura H; Honjo T
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice.
Nature 1992;357(6373):77-80.
1992: Aoki T; Tashiro K; Miyatake S; Kinashi T; Nakano T; Oda Y; Kikuchi H; Honjo T
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3850-4.
1992: Takahashi Y; Shimizu A; Sakai T; Endo Y; Osawa N; Shisa H; Honjo T
Mapping of the nu gene using congenic nude strains and in situ hybridization.
The Journal of experimental medicine 1992;175(3):873-6.
1992: Kawaichi M; Oka C; Shibayama S; Koromilas A E; Matsunami N; Hamaguchi Y; Honjo T
Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
The Journal of biological chemistry 1992;267(6):4016-22.
1992: Okamoto M; Murakami M; Shimizu A; Ozaki S; Tsubata T; Kumagai S; Honjo T
A transgenic model of autoimmune hemolytic anemia.
The Journal of experimental medicine 1992;175(1):71-9.
1992: Saito Y; Tada H; Nazarea M; Honjo T
Interleukin 2 and tumor necrosis factor alpha are complementary for proliferation of the hematopoietic stem cell line LyD9.
Growth factors (Chur, Switzerland) 1992;7(4):297-303.
1991: Shin E K; Matsuda F; Nagaoka H; Fukita Y; Imai T; Yokoyama K; Soeda E; Honjo T
Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.
The EMBO journal 1991;10(12):3641-5.
1991: Han H; Okamoto M; Honjo T; Shimizu A
Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic mu chain and constant regions of endogenous isotypes.
International immunology 1991;3(12):1197-206.
1991: Furukawa T; Kawaichi M; Matsunami N; Ryo H; Nishida Y; Honjo T
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
The Journal of biological chemistry 1991;266(34):23334-40.
1991: Saito Y; Tada H; Sabe H; Honjo T
Biochemical evidence for a third chain of the interleukin-2 receptor.
The Journal of biological chemistry 1991;266(33):22186-91.
1991: Sabe H; Kuno J; Koromilas A; Saito Y; Kinashi T; Ueda M; Takamatsu T; Hamaguchi M; Kawakami T; Honjo T
Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3.
International immunology 1991;3(11):1137-48.
1991: Aoki T; Tashiro K; Miyatake S; Nakano T; Oda Y; Kikuchi H; Honjo T
Expression of the RAG-2 gene in murine central nervous system tumor cell lines.
Biochemical and biophysical research communications 1991;181(1):151-8.
1991: Kawaichi M; Oka C; Reeves R; Kinoshita M; Honjo T
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
The Journal of biological chemistry 1991;266(27):18387-94.
1991: Honjo T
Shared partners in receptors.
Current biology : CB 1991;1(4):201-3.
1991: Kuze K; Shimizu A; Honjo T
Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin.
International immunology 1991;3(7):647-55.
1991: Mizuta T R; Suzuki N; Shimizu A; Honjo T
Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells.
The Journal of biological chemistry 1991;266(19):12514-21.
1991: Shimizu A; Nussenzweig M C; Han H; Sanchez M; Honjo T
Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.
The Journal of experimental medicine 1991;173(6):1385-93.
1991: Tashiro K; Kinashi T; Anderson S J; Lee K H; Tohyama K; Ogawa M; Takahashi M; Kawaichi M; Honjo T
Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines.
Immunology letters 1991;28(2):147-54.
1991: Amakawa R; Fukuhara S; Ohno H; Matsuyama F; Kato I; Tanabe S; Sideras P; Mizuta T R; Honjo T; Okuma M
Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma.
Blood 1991;77(9):1970-6.
1991: Kinashi T; Lee K H; Ogawa M; Tohyama K; Tashiro K; Fukunaga R; Nagata S; Honjo T
Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture.
The Journal of experimental medicine 1991;173(5):1267-79.
1991: Lee K H; Kinashi T; Tohyama K; Tashiro K; Funato N; Hama K; Honjo T
Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9.
The Journal of experimental medicine 1991;173(5):1257-66.
1991: Morita M; Saito H; Honjo T; Saito Y; Tsuruta S; Kim K M; Tanaka M; Mori K J; Mayumi M; Mikawa H
Differentiation of a human eosinophilic leukemia cell line (EoL-1) by a human T-cell leukemia cell line (HIL-3)-derived factor.
Blood 1991;77(8):1766-75.
1991: Kinoshita K; Shimizu A; Honjo T
The membrane exons of the pseudo-gamma-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the gamma 1 gene.
Immunology letters 1991;27(2):151-5.
1991: White K N; Nosaka T; Kanamori H; Hatanaka M; Honjo T
The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor alpha subunit mRNA by p27rex.
Biochemical and biophysical research communications 1991;175(1):98-103.
1991: Hamaguchi Y; Mastunami N; Yamamoto Y; Kuze K; Kangawa K; Matsuo H; Kawaichi M; Honjo T
Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes.
Advances in experimental medicine and biology 1991;292():177-86.
1990: Kanamori H; Suzuki N; Siomi H; Nosaka T; Sato A; Sabe H; Hatanaka M; Honjo T
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
The EMBO journal 1990;9(12):4161-6.
1990: Matsuda F; Shin E K; Hirabayashi Y; Nagaoka H; Yoshida M C; Zong S Q; Honjo T
Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments.
The EMBO journal 1990;9(8):2501-6.
1990: Iwasato T; Shimizu A; Honjo T; Yamagishi H
Circular DNA is excised by immunoglobulin class switch recombination.
Cell 1990;62(1):143-9.
1990: Yao L; Nakauchi H; Honjo T; Kawakami T
The cytoplasmic domain of the CD8 alpha-chain is required for its interaction with p56lck.
Immunology letters 1990;24(4):267-71.
1990: Tohyama K; Lee K H; Tashiro K; Kinashi T; Honjo T
Establishment of an interleukin-5-dependent subclone from an interleukin-3-dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin-5.
The EMBO journal 1990;9(6):1823-30.
1990: Okamoto M; Honjo T
Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouse.
Nucleic acids research 1990;18(7):1895.
1990: Ikeda T; Kita K; Kawakami K; Ohno T; Seki S; Nasu K; Ueda T; Honjo T; Shirakawa S
Oligoclonal immunoglobulin gene rearrangements in Philadelphia chromosome-positive common acute lymphoblastic leukemia.
Japanese journal of cancer research : Gann 1990;81(4):340-4.
1990: Kinashi T; Tashiro K; Lee K H; Inaba K; Toyama K; Palacios R; Honjo T
Growth factors involved in lymphocyte differentiation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):117-25.
1990: Ohno H; Furukawa T; Fukuhara S; Zong S Q; Kamesaki H; Shows T B; Le Beau M M; McKeithan T W; Kawakami T; Honjo T
Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):628-32.
1990: Ikeda T; Kita K; Miwa H; Kawakami K; Anazawa H; Ohno T; Nosaka T; Hatanaka M; Honjo T; Shirakawa S
Genetic heterogeneity in blast crisis of chronic myelocytic leukemia.
Leukemia research 1990;14(2):195-201.
1990: Saito Y; Ogura T; Kamio M; Sabe H; Uchiyama T; Honjo T
Stepwise formation of the high-affinity complex of the interleukin 2 receptor.
International immunology 1990;2(12):1167-77.
1989: Matsunami N; Hamaguchi Y; Yamamoto Y; Kuze K; Kangawa K; Matsuo H; Kawaichi M; Honjo T
A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.
Nature 1989;342(6252):934-7.
1989: Hamaguchi Y; Matsunami N; Yamamoto Y; Honjo T
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment.
Nucleic acids research 1989;17(22):9015-26.
1989: Ishida Y; Nishi M; Taguchi O; Inaba K; Hattori M; Minato N; Kawaichi M; Honjo T
Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.
The Journal of experimental medicine 1989;170(4):1103-15.
1989: Shimizu A; Nussenzweig M C; Mizuta T R; Leder P; Honjo T
Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8020-3.
1989: Aoki T; Kikuchi H; Miyatake S; Oda Y; Iwasaki K; Yamasaki T; Kinashi T; Honjo T
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.
The Journal of experimental medicine 1989;170(2):583-8.
1989: Ohno H; Fukuhara S; Doi S; Amakawa R; Horii M; Akiyama Y; Fukuda W; Honjo T; Sugiyama T; Uchino H
Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24.
Cancer genetics and cytogenetics 1989;40(1):73-82.
1989: Noma T; Nakakubo H; Hama K; Honjo T
Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines.
Immunology letters 1989;21(4):323-8.
1989: Noma T; Nakakubo H; Sugita M; Kumagai S; Maeda M; Shimizu A; Honjo T
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
The Journal of experimental medicine 1989;169(5):1853-8.
1989: Kanamori H; Suzuki N; Ishida N; Honjo T
Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells.
Immunology letters 1989;20(4):293-8.
1989: Takahashi M; Yoshida M C; Satoh H; Hilgers J; Yaoita Y; Honjo T
Chromosomal mapping of the mouse IL-4 and human IL-5 genes.
Genomics 1989;4(1):47-52.
1989: Kuze K; Shimizu A; Honjo T
A new vector and RNase H method for the subtractive hybridization.
Nucleic acids research 1989;17(2):807.
1989: Ishida Y; Nishi M; Taguchi O; Inaba K; Minato N; Kawaichi M; Honjo T
Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():695-704.
1989: Shimizu A; Kinashi T; Nussenzweig M C; Mizuta T R; Leder P; Honjo T
Molecular mechanism for immunoglobulin double-isotype expression.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():175-81.
1989: Ishida Y; Nishi M; Taguchi O; Inaba K; Minato N; Kawaichi M; Honjo T
Effects of the deregulated expression of human interleukin-2 in transgenic mice.
International immunology 1989;1(2):113-20.
1989: Kinashi T; Tashiro K; Inaba K; Takeda T; Palacios R; Honjo T
An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes.
International immunology 1989;1(1):11-9.
1988: Saito Y; Sabe H; Suzuki N; Kondo S; Ogura T; Shimizu A; Honjo T
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.
The Journal of experimental medicine 1988;168(5):1563-72.
1988: Ohno H; Fukuhara S; Arita Y; Doi S; Takahashi R; Fujii H; Honjo T; Sugiyama T; Uchino H
Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene.
Cancer research 1988;48(17):4959-63.
1988: Yaoita Y; Takahashi M; Azuma C; Kanai Y; Honjo T
Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice.
Journal of biochemistry 1988;104(3):337-43.
1988: Maeda M; Noma T; Hama K; Honjo T
Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay.
Immunology letters 1988;18(4):247-53.
1988: Sato T; Matsuda F; Lee K H; Shin E K; Honjo T
Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus.
Biochemical and biophysical research communications 1988;154(1):265-71.
1988: Kinashi T; Inaba K; Tsubata T; Tashiro K; Palacios R; Honjo T
Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4473-7.
1988: Nosaka T; Ohno H; Doi S; Fukuhara S; Miwa H; Kita K; Shirakawa S; Honjo T; Hatanaka M
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.
The Journal of clinical investigation 1988;81(6):1824-8.
1988: Zong S Q; Nakai S; Matsuda F; Lee K H; Honjo T
Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment.
Immunology letters 1988;17(4):329-33.
1988: Miwa H; Nosaka T; Kita K; Ohno T; Matsuoka N; Shirakawa S; Arita Y; Doi S; Nishikori M; Honjo T
Immunogenotypes of lymphoid malignancies; the rearrangement of T cell receptor beta chain gene can occur before the gamma chain gene rearrangement.
Japanese journal of cancer research : Gann 1988;79(4):484-90.
1988: Matsuda F; Lee K H; Nakai S; Sato T; Kodaira M; Zong S Q; Ohno H; Fukuhara S; Honjo T
Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.
The EMBO journal 1988;7(4):1047-51.
1988: Sideras P; Noma T; Honjo T
Structure and function of interleukin 4 and 5.
Immunological reviews 1988;102():189-212.
1988: Nishi M; Ishida Y; Honjo T
Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice.
Nature 1988;331(6153):267-9.
1988: Takeda S; Hamaguchi Y; Zong S Q; Kuze K; Honjo T; Ishimoto M; Nakano T; Kitamura Y
Introduction and expression of the interleukin 2 receptor (Tac) gene in hematopoietic stem cells with retrovirus vectors.
Growth factors (Chur, Switzerland) 1988;1(1):59-66.
1988: Mizuta T R; Tanabe T; Nakakubo H; Noma T; Honjo T
Molecular cloning and structure of the mouse interleukin-5 gene.
Growth factors (Chur, Switzerland) 1988;1(1):51-7.
1988: Kinashi T; Inaba K; Tsubata T; Tashiro K; Palacios R; Honjo T
Differentiation of a precursor cell with the germline context immunoglobulin gene into immunoglobulin-producing cells in vitro.
Annals of the New York Academy of Sciences 1988;546():1-8.
1988: Ishida Y; Nishi M; Taguchi O; Inaba K; Minato N; Kawaichi M; Honjo T
Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice.
Princess Takamatsu symposia 1988;19():61-71.
1987: Tanabe T; Konishi M; Mizuta T; Noma T; Honjo T
Molecular cloning and structure of the human interleukin-5 gene.
The Journal of biological chemistry 1987;262(34):16580-4.
1987: Honjo T; Yaoita Y; Kinashi T; Noma Y; Naito T; Azuma C; Severinson E; Sideras P; Bergstedt-Lindqvist S; Takatsu K
Structure and function of interleukins 4 and 5.
Acta paediatrica Japonica; Overseas edition 1987;29(4):546-51.
1987: Noma T; Mizuta T; Rosén A; Hirano T; Kishimoto T; Honjo T
Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines.
Immunology letters 1987;15(3):249-53.
1987: Tagaya Y; Taniguchi Y; Naramura M; Okada M; Suzuki N; Kanamori H; Nikaido T; Honjo T; Yodoi J
Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines.
Immunology letters 1987;15(3):221-8.
1987: Kinashi T; Godal T; Noma Y; Ling N R; Yaoita Y; Honjo T
Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes.
Genes & development 1987;1(5):465-70.
1987: Harada N; Takahashi T; Matsumoto M; Kinashi T; Ohara J; Kikuchi Y; Koyama N; Severinson E; Yaoita Y; Honjo T
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(13):4581-5.
1987: Lee K H; Matsuda F; Kinashi T; Kodaira M; Honjo T
A novel family of variable region genes of the human immunoglobulin heavy chain.
Journal of molecular biology 1987;195(4):761-8.
1987: Suzuki N; Matsunami N; Kanamori H; Ishida N; Shimizu A; Yaoita Y; Nikaido T; Honjo T
The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts.
The Journal of biological chemistry 1987;262(11):5079-86.
1987: Miwa H; Uchida T; Kobayashi T; Kita K; Shirakawa S; Koyanagi Y; Yamamoto N; Shimizu A; Honjo T; Hatanaka M
Relationship of human cord blood mononuclear cell lines, established by the HTLV-I integration, to expression of T-cell phenotypes and the T-cell receptor gene rearrangement.
The Journal of molecular and cellular immunology : JMCI 1987;3(1):43-8.
1987: Miwa H; Konishi H; Kobayashi N; Kita K; Shirakawa S; Shimizu A; Honjo T; Hatanaka M
The T-cell receptor gene rearrangements in T-lineage tumors without OKT-3,4,6,8 markers.
The Journal of molecular and cellular immunology : JMCI 1987;3(1):37-42.
1986: Kodaira M; Kinashi T; Umemura I; Matsuda F; Noma T; Ono Y; Honjo T
Organization and evolution of variable region genes of the human immunoglobulin heavy chain.
Journal of molecular biology 1986;190(4):529-41.
1986: Matsunami N; Siomi H; Hatanaka M; Yaoita Y; Honjo T
Preferential transcription of HTLV-I LTR in cell-free extracts of human T cells producing HTLV-I viral proteins.
Nucleic acids research 1986;14(12):4779-86.
1983: Yaoita Y; Matsunami N; Choi C Y; Sugiyama H; Kishimoto T; Honjo T
The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene.
Nucleic acids research 1983;11(21):7303-16.

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