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Tasuku Honjo

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Masatoshi Aida; Nasim A Begum; Nesreen Hamad; Andre Stanlie; Tasuku Honjo
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation.
Guoxin Liang; Guangyan Liu; Kousho Wakae; Zhe Wang; Sajeda Chowdhury; Weixin Fu; Tasuku Honjo; Kouichi Kitamura; Miki Koura; Masamichi Muramatsu
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.
Le Thi Huong; Maki Kobayashi; Hitoshi Miyachi; Mikiyo Nakata; Go Shioi; Tasuku Honjo; Hitoshi Nagaoka
In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression.

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2013: Masatoshi Aida; Nasim A Begum; Nesreen Hamad; Andre Stanlie; Tasuku Honjo
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(19):7784-9.
2013: Guoxin Liang; Guangyan Liu; Kousho Wakae; Zhe Wang; Sajeda Chowdhury; Weixin Fu; Tasuku Honjo; Kouichi Kitamura; Miki Koura; Masamichi Muramatsu
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2246-51.
2013: Le Thi Huong; Maki Kobayashi; Hitoshi Miyachi; Mikiyo Nakata; Go Shioi; Tasuku Honjo; Hitoshi Nagaoka
In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression.
PloS one 2013;8(4):e61433.
2012: Nasim A Begum; Mikiyo Nakata; Andre Stanlie; Hideo Akiyama; Tasuku Honjo
The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
The Journal of biological chemistry 2012;287(39):32415-29.
2012: Nasim A Begum; Tasuku Honjo
Evolutionary comparison of the mechanism of DNA cleavage with respect to immune diversity and genomic instability.
Biochemistry 2012;51(26):5243-56.
2012: Shunsuke Chikuma; Il-mi Okazaki; Shiro Shibayama; Naomasa Suita; Tasuku Honjo
TRIM28 prevents autoinflammatory T cell development in vivo.
Nature immunology 2012;13(6):596-603.
2012: Lucia Kato; Maki Kobayashi; Andre Stanlie; Masatoshi Aida; Nasim A Begum; Tasuku Honjo
An evolutionary view of the mechanism for immune and genome diversity.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3559-66.
2012: Lucia Kato; Takahisa Kawaguchi; Jun Kawai; Fumihiko MATSUDA; Nasim A Begum; A Maxwell Burroughs; Carsten O Daub; Tomomitsu Doi; Yoshihide Hayashizaki; Tasuku Honjo
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2479-84.
2012: Andre Stanlie; Hideo Akiyama; Nasim A Begum; Tasuku Honjo
The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombination.
PLoS genetics 2012;8(4):e1002675.
2012: Tasuku Honjo; Maki Kobayashi; Ai Kotani; Nasim Begum; Somayeh Sabouri; Hitoshi Nagaoka
The AID dilemma: infection, or cancer?
Advances in cancer research 2012;113():1-44.
2011: Maki Kobayashi; Yves Pommier; Somayeh Sabouri; Zahra Sabouri; Takaya Abe; Yoko Kitawaki; Hiroshi Kiyonari; Tasuku Honjo
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(48):19305-10.
2011: Il-mi Okazaki; Katsuya Okawa; Maki Kobayashi; Kiyotsugu Yoshikawa; Shimpei Kawamoto; Hitoshi Nagaoka; Reiko Shinkura; Yoko Kitawaki; Hisaaki Taniguchi; Tohru Natsume; Shun-ichiro Iemura; Tasuku Honjo
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7920-5.
2011: Seigo Terawaki; Shunsuke Chikuma; Shiro Shibayama; Tamon Hayashi; Takao Yoshida; Taku Okazaki; Tasuku Honjo
IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):2772-9.
2010: Andre Stanlie; Masatoshi Aida; Masamichi Muramatsu; Tasuku Honjo; Nasim A Begum
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(51):22190-5.
2010: Jian Wang; Il-mi Okazaki; Taku Yoshida; Shunsuke Chikuma; Yu Kato; Fumio Nakaki; Hiroshi Hiai; Tasuku Honjo; Taku Okazaki
PD-1 deficiency results in the development of fatal myocarditis in MRL mice.
International immunology 2010;22(6):443-52.
2010: Hitoshi Nagaoka; Thinh Huy Tran; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo
Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity.
International immunology 2010;22(4):227-35.
2010: Thinh Huy Tran; Mikiyo Nakata; Keiichiro Suzuki; Nasim A Begum; Reiko Shinkura; Sidonia Fagarasan; Tasuku Honjo; Hitoshi Nagaoka
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers.
Nature immunology 2010;11(2):148-54.
2010: Kenji Tanigaki; Tasuku Honjo
Two opposing roles of RBP-J in Notch signaling.
Current topics in developmental biology 2010;92():231-52.
2009: Maki Kobayashi; Masatoshi Aida; Hitoshi Nagaoka; Nasim A Begum; Yoko Kitawaki; Mikiyo Nakata; Andre Stanlie; Tomomitsu Doi; Lucia Kato; Il-mi Okazaki; Reiko Shinkura; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22375-80.
2009: Motoaki Fujimoto; Yasushi Takagi; Kazue Muraki; Kazuhiko Nozaki; Norio Yamamoto; Masayuki Tsuji; Nobuo Hashimoto; Tasuku Honjo; Kenji Tanigaki
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
Developmental biology 2009;332(2):339-50.
2009: Zahra Sabouri; Il-mi Okazaki; Reiko Shinkura; Nasim Begum; Hitoshi Nagaoka; Daisuke Tsuchimoto; Yusaku Nakabeppu; Tasuku Honjo
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
International immunology 2009;21(8):947-55.
2009: Shunsuke Chikuma; Seigo Terawaki; Tamon Hayashi; Ryusuke Nabeshima; Takao Yoshida; Shiro Shibayama; Taku Okazaki; Tasuku Honjo
PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6682-9.
2009: Fang Jiang; Taku Yoshida; Fumio Nakaki; Seigo Terawaki; Shunsuke Chikuma; Yu Kato; Il-mi Okazaki; Tasuku Honjo; Taku Okazaki
Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.
International immunology 2009;21(5):499-509.
2009: Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A Begum; Hitoshi Nagaoka; Il-mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo
Molecular mechanism for generation of antibody memory.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1517):569-75.
2009: Tomomitsu Doi; Lucia Kato; Satomi Ito; Reiko Shinkura; Min Wei; Hitoshi Nagaoka; Jishu Wang; Tasuku Honjo
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2758-63.
2009: Nasim A Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2752-7.
2009: Taichiro Nonaka; Tomomitsu Doi; Takae Toyoshima; Masamichi Muramatsu; Tasuku Honjo; Kazuo Kinoshita
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2747-51.
2009: A Takai; T Toyoshima; M Uemura; Y Kitawaki; Hiroyuki Marusawa; Hiroshi Hiai; Shigehito Yamada; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba; Kazuo Kinoshita
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.
Oncogene 2009;28(4):469-78.
2008: Velizar Shivarov; Reiko Shinkura; Tasuku Honjo
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(41):15866-71.
2008: Masahiro Kido; Norihiko Watanabe; Taku Okazaki; Takuji Akamatsu; Junya Tanaka; Kazuyuki Saga; Akiyoshi Nishio; Tasuku Honjo; Tsutomu Chiba
Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling.
Gastroenterology 2008;135(4):1333-43.
2008: Yoko Endo; Hiroyuki Marusawa; Tadayuki Kou; Hiroshi Nakase; Shigehiko Fujii; Takahiro Fujimori; Kazuo Kinoshita; Tasuku Honjo; Tsutomu Chiba
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.
Gastroenterology 2008;135(3):889-98, 898.e1-3.
2008: Fabienne Haspot; Thomas Fehr; Carrie Gibbons; Guiling Zhao; Timothy Hogan; Tasuku Honjo; Gordon J Freeman; Megan Sykes
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.
Blood 2008;112(5):2149-55.
2008: Tasuku Honjo
A memoir of AID, which engraves antibody memory on DNA.
Nature immunology 2008;9(4):335-7.
2008: Orbicia Riccio; Marielle E van Gijn; April C Bezdek; Luca Pellegrinet; Johan H van Es; Ursula Zimber-Strobl; Lothar Strobl; Tasuku Honjo; Hans Clevers; Freddy Radtke
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
EMBO reports 2008;9(4):377-83.
2008: Taku Yoshida; Fang Jiang; Tasuku Honjo; Taku Okazaki
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3533-8.
2007: Yoko Endo; Hiroyuki Marusawa; Kazuo Kinoshita; Toshiyuki Morisawa; T Sakurai; Il-mi Okazaki; Koichi Watashi; Kunitada Shimotohno; Tasuku Honjo; Tsutomu Chiba
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.
Oncogene 2007;26(38):5587-95.
2007: Seigo Terawaki; Yoshimasa Tanaka; Tomokazu Nagakura; Tamon Hayashi; Shiro Shibayama; Kaori Muroi; Taku Okazaki; Bunzo Mikami; David N Garboczi; Tasuku Honjo; Nagahiro Minato
Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function.
International immunology 2007;19(7):881-90.
2007: Shinji Takebayashi; Norio Yamamoto; Yabe Daisuke; Hitoshi Fukuda; Ken Kojima; Juichi Ito; Tasuku Honjo
Multiple roles of Notch signaling in cochlear development.
Developmental biology 2007;307(1):165-78.
2007: Yabe Daisuke; Hitoshi Fukuda; Misayo Aoki; Shuichi Yamada; Shinji Takebayashi; Reiko Shinkura; Norio Yamamoto; Tasuku Honjo
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.
Genesis (New York, N.Y. : 2000) 2007;45(5):300-6.
2007: Yuko Matsumoto; Hiroyuki Marusawa; Kazuo Kinoshita; Yoko Endo; Tadayuki Kou; Toshiyuki Morisawa; Takeshi Azuma; Il-mi Okazaki; Tasuku Honjo; Tsutomu Chiba
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
Nature medicine 2007;13(4):470-6.
2007: Junzo Hamanishi; Michiko Mandai; Masashi Iwasaki; Taku Okazaki; Yoshimasa Tanaka; Ken Yamaguchi; Toshihiro Higuchi; Haruhiko Yagi; Kenji Takakura; Nagahiro Minato; Tasuku Honjo; Shingo Fujii
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3360-5.
2007: Ai Kotani; Naoki Kakazu; Tsuruyama Tatsuaki; Il-mi Okazaki; Masamichi Muramatsu; Kazuo Kinoshita; Hitoshi Nagaoka; Yabe Daisuke; Tasuku Honjo
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1616-20.
2007: Masayuki Tsuji; Reiko Shinkura; Kazuki Kuroda; Yabe Daisuke; Tasuku Honjo
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1610-5.
2007: Nasim A Begum; Nakako Izumi; Momoko Nishikori; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo
Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.
The Journal of biological chemistry 2007;282(1):731-42.
2007: Il-mi Okazaki; Ai Kotani; Tasuku Honjo
Role of AID in tumorigenesis.
Advances in immunology 2007;94():245-73.
2007: Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Nasim A Begum; Tasuku Honjo
Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.
Advances in immunology 2007;94():1-36.
2007: Reiko Shinkura; Il-mi Okazaki; Taro Muto; Nasim A Begum; Tasuku Honjo
Regulation of AID function in vivo.
Advances in experimental medicine and biology 2007;596():71-81.
2006: Jishu Wang; Reiko Shinkura; Masamichi Muramatsu; Hitoshi Nagaoka; Kazuo Kinoshita; Tasuku Honjo
Identification of a specific domain required for dimerization of activation-induced cytidine deaminase.
The Journal of biological chemistry 2006;281(28):19115-23.
2006: Shinya Tanaka; Jun Tsukada; Wataru Suzuki; Katsuhiko Hayashi; Kenji Tanigaki; Masayuki Tsuji; Hiromasa Inoue; Tasuku Honjo; Masato Kubo
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.
Immunity 2006;24(6):689-701.
2006: Koichi Ikuta; Ryoichiro Kageyama; Tasuku Honjo
The 20th IUBMB International Congress in Kyoto.
IUBMB life 2006;58(5-6):258.
2006: Taku Okazaki; Tasuku Honjo
The PD-1-PD-L pathway in immunological tolerance.
Trends in immunology 2006;27(4):195-201.
2006: Taro Muto; Il-mi Okazaki; Shuichi Yamada; Yoshimasa Tanaka; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo
Negative regulation of activation-induced cytidine deaminase in B cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2752-7.
2006: Taku Okazaki; Tasuku Honjo
Rejuvenating exhausted T cells during chronic viral infection.
Cell 2006;124(3):459-61.
2006: Junji Fujikura; Kiminori Hosoda; Hiroshi Iwakura; Tsutomu Tomita; Michio Noguchi; Hiroaki Masuzaki; Kenji Tanigaki; Yabe Daisuke; Tasuku Honjo; Kazuwa Nakao
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Cell metabolism 2006;3(1):59-65.
2006: Koshou Wakae; Brad G Magor; Holly Saunders; Hitoshi Nagaoka; Akemi Kawamura; Kazuo Kinoshita; Tasuku Honjo; Masamichi Muramatsu
Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID.
International immunology 2006;18(1):41-7.
2006: Norio Yamamoto; Kenji Tanigaki; Masayuki Tsuji; Yabe Daisuke; Juichi Ito; Tasuku Honjo
Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.
Journal of molecular medicine (Berlin, Germany) 2006;84(1):37-45.
2005: Taku Okazaki; Yumi Otaka; Jian Wang; Hiroshi Hiai; Toshiyuki Takai; Jeffrey V Ravetch; Tasuku Honjo
Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice.
The Journal of experimental medicine 2005;202(12):1643-8.
2005: Tasuku Honjo
Science and government. In search of the best grant system.
Science (New York, N.Y.) 2005;309(5739):1329.
2005: Jian Wang; Taku Yoshida; Fumio Nakaki; Hiroshi Hiai; Taku Okazaki; Tasuku Honjo
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11823-8.
2005: Tasuku Honjo; Hitoshi Nagaoka; Reiko Shinkura; Masamichi Muramatsu
AID to overcome the limitations of genomic information.
Nature immunology 2005;6(7):655-61.
2005: Taku Okazaki; Tasuku Honjo
Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.
Trends in molecular medicine 2005;11(7):322-6.
2005: Ai Kotani; Il-mi Okazaki; Masamichi Muramatsu; Kazuo Kinoshita; Nasim A Begum; Toshiharu Nakajima; Hirohisa Saito; Tasuku Honjo
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4506-11.
2005: Keiichiro Suzuki; Bob Meek; Yasuko Doi; Tasuku Honjo; Sidonia Fagarasan
Two distinctive pathways for recruitment of naive and primed IgM+ B cells to the gut lamina propria.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2482-6.
2005: Hitoshi Nagaoka; Satomi Ito; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo
DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2022-7.
2005: Yo Kishi; Jun Takahashi; Mitsumasa Koyanagi; Asuka Morizane; Yo Okamoto; Satoshi Horiguchi; Kei Tashiro; Tasuku Honjo; Shingo Fujii; Nobuo Hashimoto
Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells.
Journal of neuroscience research 2005;79(3):279-86.
2005: Yoshiko Iwai; Seigo Terawaki; Tasuku Honjo
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells.
International immunology 2005;17(2):133-44.
2004: Tasuku Honjo
Obituary: Yasutomi Nishizuka (1932-2004).
Nature 2004;432(7020):966.
2004: Akiko T Nishida; Kazuhiro Kobuke; Ken Kojima; Juichi Ito; Tasuku Honjo; Kei Tashiro
OC29 is preferentially expressed in the presumptive sensory organ region of the otocyst.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(4):766-74.
2004: Nasim A Begum; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):13003-7.
2004: Nasim A Begum; Kazuo Kinoshita; Naoki Kakazu; Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Detlev Biniszkiewicz; Laurie A Boyer; Rudolf Jaenisch; Tasuku Honjo
Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Science (New York, N.Y.) 2004;305(5687):1160-3.
2004: Reiko Shinkura; Satomi Ito; Nasim A Begum; Hitoshi Nagaoka; Masamichi Muramatsu; Kazuo Kinoshita; Yoshimasa Sakakibara; Hiroko Hijikata; Tasuku Honjo
Separate domains of AID are required for somatic hypermutation and class-switch recombination.
Nature immunology 2004;5(7):707-12.
2004: Tasuku Honjo; Masamichi Muramatsu; Sidonia Fagarasan
AID: how does it aid antibody diversity?
Immunity 2004;20(6):659-68.
2004: Sidonia Fagarasan; Tasuku Honjo
Regulation of IgA synthesis at mucosal surfaces.
Current opinion in immunology 2004;16(3):277-83.
2004: Kenji Tanigaki; Masayuki Tsuji; Norio Yamamoto; Hua Han; Jun Tsukada; Hiromasa Inoue; Masato Kubo; Tasuku Honjo
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.
Immunity 2004;20(5):611-22.
2004: Satoshi Horiguchi; Jun Takahashi; Yo Kishi; Asuka Morizane; Yo Okamoto; Mitsumasa Koyanagi; Masayuki Tsuji; Kei Tashiro; Tasuku Honjo; Shingo Fujii; Nobuo Hashimoto
Neural precursor cells derived from human embryonic brain retain regional specificity.
Journal of neuroscience research 2004;75(6):817-24.
2004: Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1975-80.
2004: Keiichiro Suzuki; Bob Meek; Yasuko Doi; Masamichi Muramatsu; Tsutomu Chiba; Tasuku Honjo; Sidonia Fagarasan
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1981-6.
2003: Taku Okazaki; Yoshimasa Tanaka; Ryosuke Nishio; Tamotsu Mitsuiye; Akira Mizoguchi; Jian Wang; Masayoshi Ishida; Hiroshi Hiai; Akira Matsumori; Nagahiro Minato; Tasuku Honjo
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice.
Nature medicine 2003;9(12):1477-83.
2003: Tomonori Eto; Kazuo Kinoshita; Kiyotsugu Yoshikawa; Masamichi Muramatsu; Tasuku Honjo
RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12895-8.
2003: Hiroki Toda; Masayuki Tsuji; Ichiro Nakano; Kazuhiro Kobuke; Takeshi Hayashi; Hironori Kasahara; Jun Takahashi; Akira Mizoguchi; Takeshi Houtani; Tetsuo Sugimoto; Nobuo Hashimoto; Theo D Palmer; Tasuku Honjo; Kei Tashiro
Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.
The Journal of biological chemistry 2003;278(37):35491-500.
2003: Van-Thanh Ta; Hitoshi Nagaoka; Nadia Catalan; Anne Durandy; Alain Fischer; Kohsuke Imai; Shigeaki Nonoyama; Junko Tashiro; Masaya Ikegawa; Satomi Ito; Kazuo Kinoshita; Masamichi Muramatsu; Tasuku Honjo
AID mutant analyses indicate requirement for class-switch-specific cofactors.
Nature immunology 2003;4(9):843-8.
2003: Yoshiko Iwai; Seigo Terawaki; Masaya Ikegawa; Taku Okazaki; Tasuku Honjo
PD-1 inhibits antiviral immunity at the effector phase in the liver.
The Journal of experimental medicine 2003;198(1):39-50.
2003: Il-mi Okazaki; Hiroshi Hiai; Naoki Kakazu; Shuichi Yamada; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
Constitutive expression of AID leads to tumorigenesis.
The Journal of experimental medicine 2003;197(9):1173-81.
2003: Mito Kanatsu-Shinohara; Shinya Toyokuni; Takeshi Morimoto; Shigeyuki Matsui; Tasuku Honjo; Takashi Shinohara
Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation.
Biology of reproduction 2003;68(5):1801-7.
2003: Il-mi Okazaki; Kiyotsugu Yoshikawa; Kazou Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo
Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation.
Annals of the New York Academy of Sciences 2003;987():1-8.
2003: Kenji Tanigaki; Kazuki Kuroda; Hua Han; Tasuku Honjo
Regulation of B cell development by Notch/RBP-J signaling.
Seminars in immunology 2003;15(2):113-9.
2003: Tomomitsu Doi; Kazuo Kinoshita; Masaya Ikegawa; Masamichi Muramatsu; Tasuku Honjo
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2634-8.
2003: Norio Yamamoto; Kenji Tanigaki; Hua Han; Hiroshi Hiai; Tasuku Honjo
Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.
Current biology : CB 2003;13(4):333-8.
2003: Norihiko Watanabe; Koichi Ikuta; Kazuichi Okazaki; Hiroshi Nakase; Yasuhiko Tabata; Minoru Matsuura; Hiroyuki Tamaki; Chiharu Kawanami; Tasuku Honjo; Tsutomu Chiba
Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice.
Digestive diseases and sciences 2003;48(2):408-14.
2003: Kazuki Kuroda; Hua Han; Shoichi Tani; Kenji Tanigaki; Tin Tun; Takahisa Furukawa; Yoshihito Taniguchi; Hisanori Kurooka; Yoshio Hamada; Shinya Toyokuni; Tasuku Honjo
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.
Immunity 2003;18(2):301-12.
2003: Sidonia Fagarasan; Tasuku Honjo
Intestinal IgA synthesis: regulation of front-line body defences.
Nature reviews. Immunology 2003;3(1):63-72.
2003: Mito Kanatsu-Shinohara; Narumi Ogonuki; Kimiko Inoue; Atsuo Ogura; Shinya Toyokuni; Tasuku Honjo; Takashi Shinohara
Allogeneic offspring produced by male germ line stem cell transplantation into infertile mouse testis.
Biology of reproduction 2003;68(1):167-73.
2002: Takashi Shinohara; Kazutomo Inoue; Narumi Ogonuki; Mito Kanatsu-Shinohara; Hiromi Miki; K Nakata; Mayuko Kurome; H Nagashima; Shinya Toyokuni; K Kogishi; Tasuku Honjo; Atsuo Ogura
Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination.
Human reproduction (Oxford, England) 2002;17(12):3039-45.
2002: Taku Okazaki; Yoshiko Iwai; Tasuku Honjo
New regulatory co-receptors: inducible co-stimulator and PD-1.
Current opinion in immunology 2002;14(6):779-82.
2002: Sidonia Fagarasan; Masamichi Muramatsu; Keiichiro Suzuki; Hitoshi Nagaoka; Hiroshi Hiai; Tasuku Honjo
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora.
Science (New York, N.Y.) 2002;298(5597):1424-7.
2002: Masayoshi Ishida; Yoshiko Iwai; Yoshimasa Tanaka; Taku Okazaki; Gordon J Freeman; Nagahiro Minato; Tasuku Honjo
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.
Immunology letters 2002;84(1):57-62.
2002: Yoshiko Iwai; Taku Okazaki; Hiroyuki Nishimura; Akemi Kawasaki; Hideo Yagita; Tasuku Honjo
Microanatomical localization of PD-1 in human tonsils.
Immunology letters 2002;83(3):215-20.
2002: Yoshiko Iwai; Masayoshi Ishida; Yoshimasa Tanaka; Taku Okazaki; Tasuku Honjo; Nagahiro Minato
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12293-7.
2002: Norihiko Watanabe; Koichi Ikuta; Sazuku Nisitani; Tsutomu Chiba; Tasuku Honjo
Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice.
The Journal of experimental medicine 2002;196(1):141-6.
2002: Kiyotsugu Yoshikawa; Il-mi Okazaki; Tomonori Eto; Kazuo Kinoshita; Masamichi Muramatsu; Hitoshi Nagaoka; Tasuku Honjo
AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts.
Science (New York, N.Y.) 2002;296(5575):2033-6.
2002: Hua Han; Kenji Tanigaki; Norio Yamamoto; Kazuki Kuroda; Momoko Yoshimoto; Tatsutoshi Nakahata; Koichi Ikuta; Tasuku Honjo
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
International immunology 2002;14(6):637-45.
2002: Kenji Tanigaki; Hua Han; Norio Yamamoto; Kei Tashiro; Masaya Ikegawa; Kazuki Kuroda; Akira Suzuki; Toru Nakano; Tasuku Honjo
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Nature immunology 2002;3(5):443-50.
2002: Il-mi Okazaki; Kazuo Kinoshita; Masamichi Muramatsu; Kiyotsugu Yoshikawa; Tasuku Honjo
The AID enzyme induces class switch recombination in fibroblasts.
Nature 2002;416(6878):340-5.
2002: Yoshihito Taniguchi; Helena Karlström; Johan Lundkvist; Tomohiko Mizutani; Akira Otaka; Monica Vestling; alan bernstein; Dorit B Donoviel; Urban Lendahl; Tasuku Honjo
Notch receptor cleavage depends on but is not directly executed by presenilins.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):4014-9.
2002: Hitoshi Nagaoka; Masamichi Muramatsu; Norio Yamamura; Kazuo Kinoshita; Tasuku Honjo
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation.
The Journal of experimental medicine 2002;195(4):529-34.
2002: Mito Kanatsu-Shinohara; Atsuo Ogura; Masaya Ikegawa; Kimiko Inoue; Narumi Ogonuki; Kei Tashiro; Shinya Toyokuni; Tasuku Honjo; Takashi Shinohara
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1383-8.
2002: Tasuku Honjo; Kazuo Kinoshita; Masamichi Muramatsu
Molecular mechanism of class switch recombination: linkage with somatic hypermutation.
Annual review of immunology 2002;20():165-96.
2001: X Chen; Kazuo Kinoshita; Tasuku Honjo
Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13860-5.
2001: Toshiro Okazaki; A Maeda; H Nishimura; T Kurosaki; Tasuku Honjo
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13866-71.
2001: Sang-Kyu Ye; Yasutoshi Agata; Hai-Chon Lee; Hisanori Kurooka; T Kitamura; Akira Shimizu; Tasuku Honjo; Koichi Ikuta
The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation.
Immunity 2001;15(5):813-23.
2001: Kazuo Kinoshita; M Harigai; Sidonia Fagarasan; Masamichi Muramatsu; Tasuku Honjo
A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12620-3.
2001: Sidonia Fagarasan; Kazuo Kinoshita; Masamichi Muramatsu; Koichi Ikuta; Tasuku Honjo
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria.
Nature 2001;413(6856):639-43.
2001: Anne Durandy; Tasuku Honjo
Human genetic defects in class-switch recombination (hyper-IgM syndromes).
Current opinion in immunology 2001;13(5):543-8.
2001: Kazuhiro Kobuke; Yoshiaki Furukawa; Manabu Sugai; Kenji Tanigaki; N Ohashi; Akira Matsumori; Shigetake Sasayama; Tasuku Honjo; Kei Tashiro
ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury.
The Journal of biological chemistry 2001;276(36):34105-14.
2001: Sang-Kyu Ye; Kazushige Maki; Hai-Chon Lee; Atsushi Ito; K Kawai; H Suzuki; T W Mak; Y Chien ; Tasuku Honjo; Koichi Ikuta
Differential roles of cytokine receptors in the development of epidermal gamma delta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1929-34.
2001: Chung-Gi Lee; Kazuo Kinoshita; Arulvathani Arudchandran; Susana M Cerritelli; Robert J Crouch; Tasuku Honjo
Quantitative regulation of class switch recombination by switch region transcription.
The Journal of experimental medicine 2001;194(3):365-74.
2001: T Mizutani; Yuko Taniguchi; T Aoki; Nobuo Hashimoto; Tasuku Honjo
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9026-31.
2001: Kazuo Kinoshita; Tasuku Honjo
Linking class-switch recombination with somatic hypermutation.
Nature reviews. Molecular cell biology 2001;2(7):493-503.
2001: Hai-Chon Lee; Sang-Kyu Ye; Tasuku Honjo; Koichi Ikuta
Induction of germline transcription in the human TCR gamma locus by STAT5.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):320-6.
2001: Masaya Ikegawa; J Yuan; K Matsumoto; S Herrmann; A Iwamoto; Tetsuya Nakamura; S Matsushita; T Kimura; Tasuku Honjo; Kei Tashiro
Elevated plasma stromal cell-derived factor 1 protein level in the progression of HIV type 1 infection/AIDS.
AIDS research and human retroviruses 2001;17(7):587-95.
2001: H Nishimura; Tasuku Honjo
PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.
Trends in immunology 2001;22(5):265-8.
2001: Yasutoshi Agata; Tomoya Katakai; Sang-Kyu Ye; Manabu Sugai; Hiroyuki Gonda; Tasuku Honjo; Koichi Ikuta; Akira Shimizu
Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination.
The Journal of experimental medicine 2001;193(7):873-80.
2001: Junko Tashiro; Kazuo Kinoshita; Tasuku Honjo
Palindromic but not G-rich sequences are targets of class switch recombination.
International immunology 2001;13(4):495-505.
2001: Shoichi Tani; Hisanori Kurooka; T Aoki; N Hashimoto; Tasuku Honjo
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription.
Nucleic acids research 2001;29(6):1373-80.
2001: H Nishimura; T Okazaki; Yuetsu Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; Akira Mizoguchi; Hiroshi Hiai; N Minato; Tasuku Honjo
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
Science (New York, N.Y.) 2001;291(5502):319-22.
2001: Kenji Tanigaki; Fumiaki Nogaki; J Takahashi; Kei Tashiro; Hisanori Kurooka; Tasuku Honjo
Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.
Neuron 2001;29(1):45-55.
2000: Norihiko Watanabe; Koichi Ikuta; Sidonia Fagarasan; Shujiro Yazumi; Tsutomu Chiba; Tasuku Honjo
Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice.
The Journal of experimental medicine 2000;192(11):1577-86.
2000: Sidonia Fagarasan; Tasuku Honjo
T-Independent immune response: new aspects of B cell biology.
Science (New York, N.Y.) 2000;290(5489):89-92.
2000: Shin-ichi Yanagawa; Jong-Seo Lee; K Kakimi; Yukihiro Matsuda; Tasuku Honjo; Akinori Ishimoto
Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus.
Journal of virology 2000;74(20):9786-91.
2000: Patrick Revy; T Muto; Y Levy; Frederic Geissmann; Alessandro Plebani; Ozden Sanal; Nadia Catalan; Monique Forveille; R Dufourcq-Labelouse; A Gennery; Ilhan Tezcan; Fügen Ersoy; H Kayserili; Alberto G Ugazio; Nicole Brousse; Masamichi Muramatsu; Luigi D Notarangelo; Kazuo Kinoshita; Tasuku Honjo; Alain Fischer; Anne Durandy
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Cell 2000;102(5):565-75.
2000: Masamichi Muramatsu; Kazuo Kinoshita; Sidonia Fagarasan; Shuichi Yamada; Y Shinkai; Tasuku Honjo
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Cell 2000;102(5):553-63.
2000: Taro Muto; Masamichi Muramatsu; Masafumi Taniwaki; Kazuo Kinoshita; Tasuku Honjo
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
Genomics 2000;68(1):85-8.
2000: Sidonia Fagarasan; Norihiko Watanabe; Tasuku Honjo
Generation, expansion, migration and activation of mouse B1 cells.
Immunological reviews 2000;176():205-15.
2000: Tadashi Kamata; Fumiaki Nogaki; Sidonia Fagarasan; T Sakiyama; Ikei Kobayashi; Shigeki Miyawaki; Koichi Ikuta; Eri Muso; Hiderou Yoshida; Shigetake Sasayama; Tasuku Honjo
Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1387-94.
2000: Hisanori Kurooka; Tasuku Honjo
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.
The Journal of biological chemistry 2000;275(22):17211-20.
2000: Sidonia Fagarasan; Reiko Shinkura; Tadashi Kamata; Fumiaki Nogaki; Koichi Ikuta; K Tashiro; Tasuku Honjo
Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system.
The Journal of experimental medicine 2000;191(9):1477-86.
2000: Kazuo Kinoshita; Tasuku Honjo
Unique and unprecedented recombination mechanisms in class switching.
Current opinion in immunology 2000;12(2):195-8.
2000: H Nishimura; Tasuku Honjo; Nagahiro Minato
Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice.
The Journal of experimental medicine 2000;191(5):891-8.
2000: Sidonia Fagarasan; Reiko Shinkura; Tadashi Kamata; Fumiaki Nogaki; Koichi Ikuta; Tasuku Honjo
Mechanism of B1 cell differentiation and migration in GALT.
Current topics in microbiology and immunology 2000;252():221-9.
1999: S Minoguchi; T Ikeda; Shigeyoshi Itohara; T Kaneko; Hiroshige Okaichi; Tasuku Honjo
Studies on the cell-type specific expression of RBP-L, a RBP-J family member, by replacement insertion of beta-galactosidase.
Journal of biochemistry 1999;126(4):738-47.
1999: Norihiko Watanabe; Sazuku Nisitani; Koichi Ikuta; M Suzuki; Tsutomu Chiba; Tasuku Honjo
Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment.
The Journal of experimental medicine 1999;190(4):461-69.
1999: Tetsuya Nakamura; P Ruiz-Lozano; V Lindner; Yabe Daisuke; Masafumi Taniwaki; Yoshiaki Furukawa; Kazuhiro Kobuke; Kei Tashiro; Z Lu; N L Andon; R Schaub; Akira Matsumori; Shigetake Sasayama; K R Chien; Tasuku Honjo
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.
The Journal of biological chemistry 1999;274(32):22476-83.
1999: Sang-Kyu Ye; Kazushige Maki; T Kitamura; S Sunaga; Koichi Akashi; J Domen; I L Weissman; Tasuku Honjo; Koichi Ikuta
Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor.
Immunity 1999;11(2):213-23.
1999: H Nishimura; M Nose; Hiroshi Hiai; Nagahiro Minato; Tasuku Honjo
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
Immunity 1999;11(2):141-51.
1999: Jong-Seo Lee; Akinori Ishimoto; Tasuku Honjo; Shin-ichi Yanagawa
Murine leukemia provirus-mediated activation of the Notch1 gene leads to induction of HES-1 in a mouse T lymphoma cell line, DL-3.
FEBS letters 1999;455(3):276-80.
1999: Masamichi Muramatsu; V S Sankaranand; Shrikant Anant; Manabu Sugai; Kazuo Kinoshita; Nicholas O Davidson; Tasuku Honjo
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells.
The Journal of biological chemistry 1999;274(26):18470-6.
1999: N Kanazawa; T Nakamura; K Tashiro; M Muramatsu; K Morita; K Yoneda; K Inaba; S Imamura; Tasuku Honjo
Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.
European journal of immunology 1999;29(6):1925-32.
1999: T Sakiyama; Koichi Ikuta; Sazuku Nisitani; Kiyoshi Takatsu; Tasuku Honjo
Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice.
International immunology 1999;11(6):995-1000.
1999: Jong-Seo Lee; Tetsuya Haruna; Akinori Ishimoto; Tasuku Honjo; Shin-ichi Yanagawa
Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events.
Journal of virology 1999;73(6):5166-71.
1999: Reiko Shinkura; Kazuhiro Kitada; Fumihiko MATSUDA; K Tashiro; Koichi Ikuta; M Suzuki; K Kogishi; Tadao Serikawa; Tasuku Honjo
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase.
Nature genetics 1999;22(1):74-7.
1999: Kei Tashiro; Masaya Ikegawa; Yabe Daisuke; Tasuku Honjo
[Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(4):967-74.
1999: Kazuki Kuroda; Shoichi Tani; K Tamura; S Minoguchi; Hisanori Kurooka; Tasuku Honjo
Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis.
The Journal of biological chemistry 1999;274(11):7238-44.
1999: Kazuo Kinoshita; Chung-Gi Lee; Junko Tashiro; Masamichi Muramatsu; X C Chen; K Yoshikawa; Tasuku Honjo
Molecular mechanism of immunoglobulin class switch recombination.
Cold Spring Harbor symposia on quantitative biology 1999;64():217-26.
1999: Sazuku Nisitani; Tasuku Honjo
Breakage of B cell tolerance and autoantibody production in anti-erythrocyte transgenic mice.
International reviews of immunology 1999;18(3):259-70.
1999: Shoichi Tani; M Taniwaki; Yuko Taniguchi; S Minoguchi; Kazuki Kuroda; H Han; T Aoki; S Miyatake; N Hashimoto; Tasuku Honjo
Chromosomal mapping of two RBP-J-related genes: Kyo-T and RBP-L.
Journal of human genetics 1999;44(1):73-5.
1998: Fumihiko MATSUDA; K Ishii; P Bourvagnet; Kei-ichi Kuma; H Hayashida; T Miyata; Tasuku Honjo
The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus.
The Journal of experimental medicine 1998;188(11):2151-62.
1998: Kazuo Kinoshita; Junko Tashiro; S Tomita; Chung-Gi Lee; Tasuku Honjo
Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions.
Immunity 1998;9(6):849-58.
1998: Daisuke Hoshiyama; H Suga; Naoyuki Iwabe; Mitsumasa Koyanagi; N Nikoh; Kei-ichi Kuma; Fumihiko MATSUDA; Tasuku Honjo; Takashi Miyata
Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family.
Journal of molecular evolution 1998;47(6):640-8.
1998: Hisanori Kurooka; Kazuki Kuroda; Tasuku Honjo
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.
Nucleic acids research 1998;26(23):5448-55.
1998: Tetsuya Nakamura; Yabe Daisuke; Nobuo Kanazawa; Kei Tashiro; Shigetake Sasayama; Tasuku Honjo
Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability.
Genomics 1998;54(1):89-98.
1998: H Nishimura; Nagahiro Minato; T Nakano; Tasuku Honjo
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
International immunology 1998;10(10):1563-72.
1998: Sazuku Nisitani; T Sakiyama; Tasuku Honjo
Involvement of IL-10 in induction of autoimmune hemolytic anemia in anti-erythrocyte Ig transgenic mice.
International immunology 1998;10(8):1039-47.
1998: T Sakai; Yuko Taniguchi; K Tamura; S Minoguchi; T Fukuhara; Lothar Strobl; Ursula Zimber-Strobl; Georg W Bornkamm; Tasuku Honjo
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.
Journal of virology 1998;72(7):6034-9.
1998: Norihiko Watanabe; Takashi Nomura; Toshiyuki Takai; Tsutomu Chiba; Tasuku Honjo; T Tsubata
Antigen receptor cross-linking by anti-immunoglobulin antibodies coupled to cell surface membrane induces rapid apoptosis of normal spleen B cells.
Scandinavian journal of immunology 1998;47(6):541-7.
1998: Yabe Daisuke; Masafumi Taniwaki; Tetsuya Nakamura; Nobuo Kanazawa; Kei Tashiro; Tasuku Honjo
Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.
Genomics 1998;49(2):331-3.
1998: Manabu Sugai; Shohei Kondo; Akira Shimizu; Tasuku Honjo
Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase.
Nucleic acids research 1998;26(4):911-8.
1998: Chung-Gi Lee; Shohei Kondo; Tasuku Honjo
Frequent but biased class switch recombination in the S mu flanking regions.
Current biology : CB 1998;8(4):227-30.
1998: Yuko Taniguchi; T Furukawa; Tin Tun; Hua Han; Tasuku Honjo
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein.
Molecular and cellular biology 1998;18(1):644-54.
1997: M Murakami; Tasuku Honjo
Transgenic mouse models for B-cell dominant autoimmune diseases.
Current opinion in immunology 1997;9(6):846-50.
1997: Sazuku Nisitani; M Murakami; T Akamizu; Tomotaka Okino; K Ohmori; T Mori; M Imamura; Tasuku Honjo
Preferential localization of human CD5+ B cells in the peritoneal cavity.
Scandinavian journal of immunology 1997;46(6):541-5.
1997: H Kato; Yuko Taniguchi; Hisanori Kurooka; S Minoguchi; T Sakai; S Nomura-Okazaki; K Tamura; Tasuku Honjo
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.
Development (Cambridge, England) 1997;124(20):4133-41.
1997: Yabe Daisuke; Tetsuya Nakamura; Nobuo Kanazawa; Kei Tashiro; Tasuku Honjo
Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF.
The Journal of biological chemistry 1997;272(29):18232-9.
1997: Masayuki Yamamoto; Tasuku Honjo; MB Paumen
[Fatty acids-induced apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(10 Suppl):1637-43.
1997: Takashi Aoki; T Koike; Tomomi Nakano; KI Shibahara; H Nishimura; Haruhiko Kikuchi; Tasuku Honjo
Rat TAFII31 gene is induced upon programmed cell death in differentiated PC12 cells deprived of NGF.
Biochemical and biophysical research communications 1997;234(1):230-4.
1997: S Minoguchi; Yuko Taniguchi; H Kato; T Okazaki; Lothar Strobl; Ursula Zimber-Strobl; Georg W Bornkamm; Tasuku Honjo
RBP-L, a transcription factor related to RBP-Jkappa.
Molecular and cellular biology 1997;17(5):2679-87.
1997: Sazuku Nisitani; M Murakami; Tasuku Honjo
Anti-red blood cell immunoglobulin transgenic mice. An experimental model of autoimmune hemolytic anemia.
Annals of the New York Academy of Sciences 1997;815():246-52.
1997: H Han; Takashi Nomura; Tasuku Honjo; T Tsubata
Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in negative signaling through the antigen-receptor of B lymphocytes.
Leukemia 1997;11 Suppl 3():367-9.
1997: MB Paumen; Yoko Ishida; H Han; Masamichi Muramatsu; Y Eguchi; Y Tsujimoto; Tasuku Honjo
Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2.
Biochemical and biophysical research communications 1997;231(3):523-5.
1997: M Murakami; K Nakajima; K Yamazaki; T Muraguchi; T Serikawa; Tasuku Honjo
Effects of breeding environments on generation and activation of autoreactive B-1 cells in anti-red blood cell autoantibody transgenic mice.
The Journal of experimental medicine 1997;185(4):791-4.
1997: MB Paumen; Yoko Ishida; Masamichi Muramatsu; Masayuki Yamamoto; Tasuku Honjo
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.
The Journal of biological chemistry 1997;272(6):3324-9.
1997: Hisanori Kurooka; K Kato; S Minoguchi; Y Takahashi; J Ikeda; S Habu; N Osawa; Arthur Buchberg; K Moriwaki; Hayase Shisa; Tasuku Honjo
Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin.
Genomics 1997;39(3):331-9.
1997: T Shinohara; Tasuku Honjo
Studies in vitro on the mechanism of the epithelial/mesenchymal interaction in the early fetal thymus.
European journal of immunology 1997;27(2):522-9.
1997: Takashi Aoki; T Koike; Tomomi Nakano; KI Shibahara; S Kondo; Haruhiko Kikuchi; Tasuku Honjo
Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons.
Journal of biochemistry 1997;121(1):122-7.
1996: M Shirozu; H Tada; Kei Tashiro; T Nakamura; N D Lopez; M Nazarea; T Hamada; T Sato; Tomomi Nakano; Tasuku Honjo
Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method.
Genomics 1996;37(3):273-80.
1996: R Tsubata; Takeshi Tsubata; Hiroshi Hiai; Reiko Shinkura; Ryutaro Matsumura; T Sumida; S Miyawaki; H Ishida; S Kumagai; K Nakao; Tasuku Honjo
Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjögren's syndrome.
European journal of immunology 1996;26(11):2742-8.
1996: H Kato; T Sakai; K Tamura; S Minoguchi; Y Shirayoshi; Y Hamada; Y Tsujimoto; Tasuku Honjo
Functional conservation of mouse Notch receptor family members.
FEBS letters 1996;395(2-3):221-4.
1996: T Hamada; Kei Tashiro; H Tada; J Inazawa; M Shirozu; KI Shibahara; T Nakamura; N Martina; Tomomi Nakano; Tasuku Honjo
Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method.
Gene 1996;176(1-2):211-4.
1996: H Han; Takashi Nomura; Tasuku Honjo; Takeshi Tsubata
Differential modulation of cyclin-dependent kinase inhibitor p27Kip1 by negative signaling via the antigen receptor of B cells and positive signaling via CD40.
European journal of immunology 1996;26(10):2425-32.
1996: Takashi Akamizu; Fumihiko MATSUDA; J Okuda; H Li; H Kanda; T Watanabe; Tasuku Honjo; T Mori
Molecular analysis of stimulatory anti-thyrotropin receptor antibodies (TSAbs) involved in Graves' disease. Isolation and reconstruction of antibody genes, and production of monoclonal TSAbs.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3148-52.
1996: Reiko Shinkura; Fumihiko MATSUDA; T Sakiyama; Takeshi Tsubata; Hiroshi Hiai; M Paumen; S Miyawaki; Tasuku Honjo
Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice.
International immunology 1996;8(7):1067-75.
1996: Hisanori Kurooka; J A Segre; Y Hirano; J L Nemhauser; H Nishimura; K Yoneda; Eric S Lander; Tasuku Honjo
Rescue of the hairless phenotype in nude mice by transgenic insertion of the wild-type Hfh11 genomic locus.
International immunology 1996;8(6):961-6.
1996: Takashi Nomura; H Han; M C Howard; H Yagita; Hidetaka Yakura; Tasuku Honjo; Takeshi Tsubata
Antigen receptor-mediated B cell death is blocked by signaling via CD72 or treatment with dextran sulfate and is defective in autoimmunity-prone mice.
International immunology 1996;8(6):867-75.
1996: Tomomi Nakano; H Kodama; Tasuku Honjo
In vitro development of primitive and definitive erythrocytes from different precursors.
Science (New York, N.Y.) 1996;272(5262):722-4.
1996: H Nishimura; Yasutoshi Agata; A Kawasaki; M Sato; Sadao Imamura; Nagahiro Minato; H Yagita; T Nakano; Tasuku Honjo
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes.
International immunology 1996;8(5):773-80.
1996: Yasutoshi Agata; A Kawasaki; H Nishimura; Y Ishida; Takeshi Tsubata; H Yagita; Tasuku Honjo
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
International immunology 1996;8(5):765-72.
1996: T Shinohara; Tasuku Honjo
Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro.
European journal of immunology 1996;26(4):747-52.
1996: M Murakami; Tasuku Honjo
Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia.
Seminars in immunology 1996;8(1):3-9.
1996: M Nakamura; S Kondo; M Sugai; M Nazarea; Sadao Imamura; Tasuku Honjo
High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.
International immunology 1996;8(2):193-201.
1996: Tasuku Honjo
The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):1-9.
1996: Fumihiko MATSUDA; Tasuku Honjo
Organization of the human immunoglobulin heavy-chain locus.
Advances in immunology 1996;62():1-29.
1995: KI Shibahara; M Asano; Y Ishida; Takashi Aoki; T Koike; Tasuku Honjo
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
Gene 1995;166(2):297-301.
1995: K Tamura; Yuko Taniguchi; S Minoguchi; T Sakai; Tin Tun; T Furukawa; Tasuku Honjo
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
Current biology : CB 1995;5(12):1416-23.
1995: T Nakamura; Kei Tashiro; M Nazarea; Tomomi Nakano; Shigetake Sasayama; Tasuku Honjo
The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.
Genomics 1995;30(2):312-9.
1995: Sazuku Nisitani; Takeshi Tsubata; M Murakami; Tasuku Honjo
Administration of interleukin-5 or -10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody-transgenic mice.
European journal of immunology 1995;25(11):3047-52.
1995: C Oka; Tomomi Nakano; Andrew Wakeham; José Luis de la Pompa; Chisato Mori; T Sakai; S Okazaki; M Kawaichi; K Shiota; Tak W Mak; Tasuku Honjo
Disruption of the mouse RBP-J kappa gene results in early embryonic death.
Development (Cambridge, England) 1995;121(10):3291-301.
1995: M Murakami; Tasuku Honjo
B-1 cells and autoimmunity.
Annals of the New York Academy of Sciences 1995;764():402-9.
1995: T Sakai; T Furukawa; H Iwanari; C Oka; Tomomi Nakano; M Kawaichi; Tasuku Honjo
Loss of immunostaining of the RBP-J kappa transcription factor upon F9 cell differentiation induced by retinoic acid.
Journal of biochemistry 1995;118(3):621-8.
1995: M Shirozu; Tomomi Nakano; J Inazawa; Kei Tashiro; H Tada; T Shinohara; Tasuku Honjo
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene.
Genomics 1995;28(3):495-500.
1995: T Furukawa; Yoshitaka Kobayakawa; K Tamura; K Kimura; M Kawaichi; T Tanimura; Tasuku Honjo
Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8.
Idengaku zasshi 1995;70(4):505-24.
1995: M Murakami; H Yoshioka; T Shirai; Takeshi Tsubata; Tasuku Honjo
Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells.
International immunology 1995;7(5):877-82.
1994: M Asano; Y Ishida; Hisataka Sabe; M Kondo; K Sugamura; Tasuku Honjo
IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5373-81.
1994: T Furukawa; K Kimura; Yoshitaka Kobayakawa; K Tamura; M Kawaichi; T Tanimura; Tasuku Honjo
Genetic characterization of Drosophila RBP-J kappa (suppressor of hairless) as a neurogenic gene in adult PNS development.
Idengaku zasshi 1994;69(6):701-11.
1994: T Shinohara; Masafumi Taniwaki; Y Ishida; M Kawaichi; Tasuku Honjo
Structure and chromosomal localization of the human PD-1 gene (PDCD1).
Genomics 1994;23(3):704-6.
1994: Takeshi Tsubata; M Murakami; Sazuku Nisitani; Tasuku Honjo
Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1313):297-301.
1994: Tomomi Nakano; H Kodama; Tasuku Honjo
Generation of lymphohematopoietic cells from embryonic stem cells in culture.
Science (New York, N.Y.) 1994;265(5175):1098-101.
1994: C N Chung; Y Hamaguchi; Tasuku Honjo; M Kawaichi
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-J kappa.
Nucleic acids research 1994;22(15):2938-44.
1994: M Murakami; Takeshi Tsubata; Reiko Shinkura; Sazuku Nisitani; M Okamoto; H Yoshioka; T Usui; S Miyawaki; Tasuku Honjo
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.
The Journal of experimental medicine 1994;180(1):111-21.
1994: Sazuku Nisitani; Takeshi Tsubata; Tasuku Honjo
Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo.
International immunology 1994;6(6):909-16.
1994: Tin Tun; Y Hamaguchi; N Matsunami; T Furukawa; Tasuku Honjo; M Kawaichi
Recognition sequence of a highly conserved DNA binding protein RBP-J kappa.
Nucleic acids research 1994;22(6):965-71.
1994: E K Shin; Takashi Akamizu; Fumihiko MATSUDA; Hideo Sugawa; J Fujikura; T Mori; Tasuku Honjo
Variable regions of Ig heavy chain genes encoding antithyrotropin receptor antibodies of patients with Graves' disease.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1485-92.
1994: T Iwasato; Y Kanari; Akira Shimizu; Tasuku Honjo; Hideo Yamagishi
Transforming growth factor-beta induced class switch recombination may be modified during the cell proliferation restored by IL-2 stimulation.
Immunology letters 1994;39(2):173-8.
1994: Ryutaro Matsumura; Fumihiko MATSUDA; H Nagaoka; J Fujikura; E K Shin; Y Fukita; M Haino; Tasuku Honjo
Structural analysis of the human VH locus using nonrepetitive intergenic probes and repetitive sequence probes. Evidence for recent reshuffling.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(2):660-6.
1994: Takeshi Tsubata; M Murakami; Tasuku Honjo
Antigen-receptor cross-linking induces peritoneal B-cell apoptosis in normal but not autoimmunity-prone mice.
Current biology : CB 1994;4(1):8-17.
1993: Sazuku Nisitani; Takeshi Tsubata; M Murakami; M Okamoto; Tasuku Honjo
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.
The Journal of experimental medicine 1993;178(4):1247-54.
1993: Y Saito; M Nazarea; Tasuku Honjo
Pseudo-high-affinity IL-2 receptor and growth signal transduction in lymphocytes.
International immunology 1993;5(10):1211-7.
1993: E K Shin; Fumihiko MATSUDA; J Fujikura; Takashi Akamizu; Hideo Sugawa; T Mori; Tasuku Honjo
Cloning of a human immunoglobulin gene fragment containing both VH-D and D-JH rearrangements: implication for VH-D as an intermediate to VH-D-JH formation.
European journal of immunology 1993;23(9):2365-7.
1993: Y Fukita; T R Mizuta; M Shirozu; K Ozawa; Akira Shimizu; Tasuku Honjo
The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region.
The Journal of biological chemistry 1993;268(23):17463-70.
1993: Takeshi Tsubata; J Wu; Tasuku Honjo
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40.
Nature 1993;364(6438):645-8.
1993: R Amakawa; W Jing; K Ozawa; N Matsunami; Y Hamaguchi; Fumihiko MATSUDA; M Kawaichi; Tasuku Honjo
Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.
Genomics 1993;17(2):306-15.
1993: Kei Tashiro; H Tada; R Heilker; M Shirozu; Tomomi Nakano; Tasuku Honjo
Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins.
Science (New York, N.Y.) 1993;261(5121):600-3.
1993: M O Shimada; Y Yamada; Y Nakakuki; K Okamoto; M Fukumoto; Tasuku Honjo; Hiroshi Hiai
SL/KH strain of mice: a model of spontaneous pre-B-lymphomas.
Leukemia research 1993;17(7):573-8.
1993: T R Mizuta; Y Fukita; T Miyoshi; Akira Shimizu; Tasuku Honjo
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences.
Nucleic acids research 1993;21(8):1761-6.
1993: Hiroshi Arakawa; T Iwasato; H Hayashida; Akira Shimizu; Tasuku Honjo; Hideo Yamagishi
The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.
The Journal of biological chemistry 1993;268(7):4651-5.
1993: E K Shin; Fumihiko MATSUDA; S Ozaki; S Kumagai; O Olerup; H Ström; I Melchers; Tasuku Honjo
Polymorphism of the human immunoglobulin variable region segment V1-4.1.
Immunogenetics 1993;38(4):304-6.
1993: M Nazarea; Y Saito; S Okazaki; N Suzuki; Tasuku Honjo
A monoclonal antibody which inhibits growth of T cell lines.
Growth factors (Chur, Switzerland) 1993;9(2):139-47.
1993: Akira Shimizu; Tasuku Honjo
Synthesis and regulation of trans-mRNA encoding the immunoglobulin epsilon heavy chain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(1):149-54.
1992: Y Ishida; Yasutoshi Agata; KI Shibahara; Tasuku Honjo
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.
The EMBO journal 1992;11(11):3887-95.
1992: Tasuku Honjo
Seppuku and autoimmunity.
Science (New York, N.Y.) 1992;258(5082):591-2.
1992: Y Hamaguchi; Y Yamamoto; H Iwanari; S Maruyama; T Furukawa; N Matsunami; Tasuku Honjo
Biochemical and immunological characterization of the DNA binding protein (RBP-J kappa) to mouse J kappa recombination signal sequence.
Journal of biochemistry 1992;112(3):314-20.
1992: Hiroshi Miwa; Kenkichi Kita; T Nosaka; T Ikeda; K Kawakami; H Anazawa; K Hoshino; Toshiyuki Ohno; Tasuku Honjo; M Hatanaka
Maturational stage specific immunoglobulin heavy chain gene rearrangements, determined by D and D upstream region gene structures.
Leukemia research 1992;16(9):861-71.
1992: T Furukawa; S Maruyama; M Kawaichi; Tasuku Honjo
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.
Cell 1992;69(7):1191-7.
1992: T Iwasato; Hiroshi Arakawa; Akira Shimizu; Tasuku Honjo; Hideo Yamagishi
Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.
The Journal of experimental medicine 1992;175(6):1539-46.
1992: M Murakami; Takeshi Tsubata; M Okamoto; A Shimizu; S Kumagai; H Imura; Tasuku Honjo
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice.
Nature 1992;357(6373):77-80.
1992: T Aoki; K Tashiro; S Miyatake; T Kinashi; T Nakano; Y Oda; H Kikuchi; Tasuku Honjo
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3850-4.
1992: Y Takahashi; Akira Shimizu; T Sakai; Y Endo; N Osawa; Hayase Shisa; Tasuku Honjo
Mapping of the nu gene using congenic nude strains and in situ hybridization.
The Journal of experimental medicine 1992;175(3):873-6.
1992: M Kawaichi; C Oka; S Shibayama; A E Koromilas; N Matsunami; Y Hamaguchi; Tasuku Honjo
Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
The Journal of biological chemistry 1992;267(6):4016-22.
1992: M Okamoto; M Murakami; Akira Shimizu; S Ozaki; Takeshi Tsubata; S Kumagai; Tasuku Honjo
A transgenic model of autoimmune hemolytic anemia.
The Journal of experimental medicine 1992;175(1):71-9.
1992: Y Saito; H Tada; M Nazarea; Tasuku Honjo
Interleukin 2 and tumor necrosis factor alpha are complementary for proliferation of the hematopoietic stem cell line LyD9.
Growth factors (Chur, Switzerland) 1992;7(4):297-303.
1991: T Furukawa; M Kawaichi; N Matsunami; H Ryo; Y Nishida; Tasuku Honjo
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
The Journal of biological chemistry 1991;266(34):23334-40.
1991: E K Shin; Fumihiko MATSUDA; H Nagaoka; Y Fukita; T Imai; K Yokoyama; E Soeda; Tasuku Honjo
Physical map of the 3' region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.
The EMBO journal 1991;10(12):3641-5.
1991: H Han; M Okamoto; Tasuku Honjo; Akira Shimizu
Regulated expression of immunoglobulin trans-mRNA consisting of the variable region of a transgenic mu chain and constant regions of endogenous isotypes.
International immunology 1991;3(12):1197-206.
1991: Takashi Aoki; K Tashiro; S Miyatake; Tomomi Nakano; Y Oda; H Kikuchi; Tasuku Honjo
Expression of the RAG-2 gene in murine central nervous system tumor cell lines.
Biochemical and biophysical research communications 1991;181(1):151-8.
1991: Yoshihiko Saito; H Tada; Hisataka Sabe; Tasuku Honjo
Biochemical evidence for a third chain of the interleukin-2 receptor.
The Journal of biological chemistry 1991;266(33):22186-91.
1991: Hisataka Sabe; Junko Kuno; A Koromilas; Y Saito; T Kinashi; M Ueda; T Takamatsu; M Hamaguchi; T Kawakami; Tasuku Honjo
Comparison of protein tyrosine phosphorylation and morphological changes induced by IL-2 and IL-3.
International immunology 1991;3(11):1137-48.
1991: M Kawaichi; C Oka; R Reeves; M Kinoshita; Tasuku Honjo
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
The Journal of biological chemistry 1991;266(27):18387-94.
1991: Tasuku Honjo
Shared partners in receptors.
Current biology : CB 1991;1(4):201-3.
1991: T R Mizuta; N Suzuki; Akira Shimizu; Tasuku Honjo
Duplicated variable region genes account for double isotype expression in a human leukemic B-cell line that gives rise to single isotype-expressing cells.
The Journal of biological chemistry 1991;266(19):12514-21.
1991: K Kuze; Akira Shimizu; Tasuku Honjo
Characterization of the enhancer region for germline transcription of the gamma 3 constant region gene of human immunoglobulin.
International immunology 1991;3(7):647-55.
1991: Akira Shimizu; Michel C Nussenzweig; H Han; M Sanchez; Tasuku Honjo
Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.
The Journal of experimental medicine 1991;173(6):1385-93.
1991: K Tashiro; T Kinashi; S J Anderson; K H Lee; K Tohyama; M Ogawa; M Takahashi; M Kawaichi; Tasuku Honjo
Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines.
Immunology letters 1991;28(2):147-54.
1991: R Amakawa; Shirou Fukuhara; Hitoshi Ohno; F Matsuyama; I Kato; S Tanabe; P Sideras; T R Mizuta; Tasuku Honjo; M Okuma
Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma.
Blood 1991;77(9):1970-6.
1991: T Kinashi; K H Lee; M Ogawa; K Tohyama; K Tashiro; R Fukunaga; S Nagata; Tasuku Honjo
Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture.
The Journal of experimental medicine 1991;173(5):1267-79.
1991: K H Lee; T Kinashi; K Tohyama; K Tashiro; N Funato; K Hama; Tasuku Honjo
Different stromal cell lines support lineage-selective differentiation of the multipotential bone marrow stem cell clone LyD9.
The Journal of experimental medicine 1991;173(5):1257-66.
1991: M Morita; H Saito; Tasuku Honjo; Y Saito; S Tsuruta; K M Kim; M Tanaka; Kazuhiro J Mori; Mitsufumi Mayumi; H Mikawa
Differentiation of a human eosinophilic leukemia cell line (EoL-1) by a human T-cell leukemia cell line (HIL-3)-derived factor.
Blood 1991;77(8):1766-75.
1991: K N White; T Nosaka; H Kanamori; M Hatanaka; Tasuku Honjo
The nucleolar localisation signal of the HTLV-I protein p27rex is important for stabilisation of IL-2 receptor alpha subunit mRNA by p27rex.
Biochemical and biophysical research communications 1991;175(1):98-103.
1991: K Kinoshita; Akira Shimizu; Tasuku Honjo
The membrane exons of the pseudo-gamma-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the gamma 1 gene.
Immunology letters 1991;27(2):151-5.
1991: Y Hamaguchi; N Mastunami; Y Yamamoto; K Kuze; K Kangawa; H Matsuo; M Kawaichi; Tasuku Honjo
Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes.
Advances in experimental medicine and biology 1991;292():177-86.
1990: H Kanamori; N Suzuki; H Siomi; T Nosaka; A Sato; Hisataka Sabe; M Hatanaka; Tasuku Honjo
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
The EMBO journal 1990;9(12):4161-6.
1990: Fumihiko MATSUDA; E K Shin; Y Hirabayashi; H Nagaoka; M C Yoshida; S Q Zong; Tasuku Honjo
Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments.
The EMBO journal 1990;9(8):2501-6.
1990: T Iwasato; Akira Shimizu; Tasuku Honjo; Hideo Yamagishi
Circular DNA is excised by immunoglobulin class switch recombination.
Cell 1990;62(1):143-9.
1990: L Yao; H Nakauchi; Tasuku Honjo; T Kawakami
The cytoplasmic domain of the CD8 alpha-chain is required for its interaction with p56lck.
Immunology letters 1990;24(4):267-71.
1990: K Tohyama; K H Lee; K Tashiro; T Kinashi; Tasuku Honjo
Establishment of an interleukin-5-dependent subclone from an interleukin-3-dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin-5.
The EMBO journal 1990;9(6):1823-30.
1990: M Okamoto; Tasuku Honjo
Nucleotide sequences of the gene/cDNA coding for anti-murine erythrocyte autoantibody produced by a hybridoma from NZB mouse.
Nucleic acids research 1990;18(7):1895.
1990: T Ikeda; Kenkichi Kita; K Kawakami; Toshiyuki Ohno; S Seki; K Nasu; T Ueda; Tasuku Honjo; S Shirakawa
Oligoclonal immunoglobulin gene rearrangements in Philadelphia chromosome-positive common acute lymphoblastic leukemia.
Japanese journal of cancer research : Gann 1990;81(4):340-4.
1990: T Kinashi; K Tashiro; K H Lee; Kayo Inaba; K Toyama; R Palacios; Tasuku Honjo
Growth factors involved in lymphocyte differentiation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1239):117-25.
1990: T Ikeda; Kenkichi Kita; Hiroshi Miwa; K Kawakami; H Anazawa; Toshiyuki Ohno; T Nosaka; M Hatanaka; Tasuku Honjo; S Shirakawa
Genetic heterogeneity in blast crisis of chronic myelocytic leukemia.
Leukemia research 1990;14(2):195-201.
1990: Hitoshi Ohno; T Furukawa; Shirou Fukuhara; S Q Zong; H Kamesaki; T B Shows; M M Le Beau; T W McKeithan; T Kawakami; Tasuku Honjo
Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):628-32.
1990: Y Saito; T Ogura; M Kamio; Hisataka Sabe; Takashi Uchiyama; Tasuku Honjo
Stepwise formation of the high-affinity complex of the interleukin 2 receptor.
International immunology 1990;2(12):1167-77.
1989: N Matsunami; Y Hamaguchi; Y Yamamoto; K Kuze; K Kangawa; H Matsuo; M Kawaichi; Tasuku Honjo
A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.
Nature 1989;342(6252):934-7.
1989: Y Hamaguchi; N Matsunami; Y Yamamoto; Tasuku Honjo
Purification and characterization of a protein that binds to the recombination signal sequence of the immunoglobulin J kappa segment.
Nucleic acids research 1989;17(22):9015-26.
1989: Y Ishida; M Nishi; O Taguchi; Kayo Inaba; M Hattori; Nagahiro Minato; M Kawaichi; Tasuku Honjo
Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice.
The Journal of experimental medicine 1989;170(4):1103-15.
1989: Akira Shimizu; Michel C Nussenzweig; T R Mizuta; P Leder; Tasuku Honjo
Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8020-3.
1989: T Aoki; H Kikuchi; S Miyatake; Y Oda; K Iwasaki; T Yamasaki; T Kinashi; Tasuku Honjo
Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity.
The Journal of experimental medicine 1989;170(2):583-8.
1989: Hitoshi Ohno; Shirou Fukuhara; S Doi; R Amakawa; M Horii; Y Akiyama; W Fukuda; Tasuku Honjo; Taketoshi Sugiyama; H Uchino
Involvement of c-myc oncogene in lymphoma cell lines with no detectable chromosome rearrangement of band 8q24.
Cancer genetics and cytogenetics 1989;40(1):73-82.
1989: T Noma; H Nakakubo; K Hama; Tasuku Honjo
Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines.
Immunology letters 1989;21(4):323-8.
1989: T Noma; H Nakakubo; M Sugita; S Kumagai; M Maeda; Akira Shimizu; Tasuku Honjo
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
The Journal of experimental medicine 1989;169(5):1853-8.
1989: H Kanamori; N Suzuki; N Ishida; Tasuku Honjo
Transcriptional regulation alone does not explain the constitutive expression of the interleukin 2 receptor (Tac/L-chain) in HTLV-1 infected cells.
Immunology letters 1989;20(4):293-8.
1989: K Kuze; Akira Shimizu; Tasuku Honjo
A new vector and RNase H method for the subtractive hybridization.
Nucleic acids research 1989;17(2):807.
1989: Y Ishida; M Nishi; O Taguchi; K Inaba; Nagahiro Minato; M Kawaichi; Tasuku Honjo
Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():695-704.
1989: Akira Shimizu; T Kinashi; Michel C Nussenzweig; T R Mizuta; P Leder; Tasuku Honjo
Molecular mechanism for immunoglobulin double-isotype expression.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():175-81.
1989: M Takahashi; M C Yoshida; H Satoh; J Hilgers; Y Yaoita; Tasuku Honjo
Chromosomal mapping of the mouse IL-4 and human IL-5 genes.
Genomics 1989;4(1):47-52.
1989: Y Ishida; M Nishi; O Taguchi; Kayo Inaba; Nagahiro Minato; M Kawaichi; Tasuku Honjo
Effects of the deregulated expression of human interleukin-2 in transgenic mice.
International immunology 1989;1(2):113-20.
1989: T Kinashi; K Tashiro; Kayo Inaba; T Takeda; R Palacios; Tasuku Honjo
An interleukin-4-dependent precursor clone is an intermediate of the differentiation pathway from an interleukin-3-dependent precursor clone into myeloid cells as well as B lymphocytes.
International immunology 1989;1(1):11-9.
1988: Y Saito; Hisataka Sabe; N Suzuki; S Kondo; T Ogura; Akira Shimizu; Tasuku Honjo
A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.
The Journal of experimental medicine 1988;168(5):1563-72.
1988: Hitoshi Ohno; Shirou Fukuhara; Y Arita; S Doi; R Takahashi; H Fujii; Tasuku Honjo; Taketoshi Sugiyama; H Uchino
Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene.
Cancer research 1988;48(17):4959-63.
1988: Y Yaoita; M Takahashi; C Azuma; Y Kanai; Tasuku Honjo
Biased expression of variable region gene families of the immunoglobulin heavy chain in autoimmune-prone mice.
Journal of biochemistry 1988;104(3):337-43.
1988: M Maeda; T Noma; K Hama; Tasuku Honjo
Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay.
Immunology letters 1988;18(4):247-53.
1988: Takashi Sato; Fumihiko MATSUDA; K H Lee; E K Shin; Tasuku Honjo
Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus.
Biochemical and biophysical research communications 1988;154(1):265-71.
1988: T Kinashi; Kayo Inaba; Takeshi Tsubata; K Tashiro; R Palacios; Tasuku Honjo
Differentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4473-7.
1988: T Nosaka; Hitoshi Ohno; S Doi; Shirou Fukuhara; Hiroshi Miwa; Kenkichi Kita; S Shirakawa; Tasuku Honjo; M Hatanaka
Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin.
The Journal of clinical investigation 1988;81(6):1824-8.
1988: S Q Zong; S Nakai; Fumihiko MATSUDA; K H Lee; Tasuku Honjo
Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment.
Immunology letters 1988;17(4):329-33.
1988: Hiroshi Miwa; T Nosaka; Kenkichi Kita; Toshiyuki Ohno; N Matsuoka; S Shirakawa; Y Arita; S Doi; M Nishikori; Tasuku Honjo
Immunogenotypes of lymphoid malignancies; the rearrangement of T cell receptor beta chain gene can occur before the gamma chain gene rearrangement.
Japanese journal of cancer research : Gann 1988;79(4):484-90.
1988: Fumihiko MATSUDA; K H Lee; S Nakai; Takashi Sato; M Kodaira; S Q Zong; Hitoshi Ohno; Shirou Fukuhara; Tasuku Honjo
Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.
The EMBO journal 1988;7(4):1047-51.
1988: P Sideras; T Noma; Tasuku Honjo
Structure and function of interleukin 4 and 5.
Immunological reviews 1988;102():189-212.
1988: M Nishi; Y Ishida; Tasuku Honjo
Expression of functional interleukin-2 receptors in human light chain/Tac transgenic mice.
Nature 1988;331(6153):267-9.
1988: S Takeda; Y Hamaguchi; S Q Zong; K Kuze; Tasuku Honjo; M Ishimoto; T Nakano; Y Kitamura
Introduction and expression of the interleukin 2 receptor (Tac) gene in hematopoietic stem cells with retrovirus vectors.
Growth factors (Chur, Switzerland) 1988;1(1):59-66.
1988: T R Mizuta; T Tanabe; H Nakakubo; T Noma; Tasuku Honjo
Molecular cloning and structure of the mouse interleukin-5 gene.
Growth factors (Chur, Switzerland) 1988;1(1):51-7.
1988: T Kinashi; Kayo Inaba; Takeshi Tsubata; K Tashiro; R Palacios; Tasuku Honjo
Differentiation of a precursor cell with the germline context immunoglobulin gene into immunoglobulin-producing cells in vitro.
Annals of the New York Academy of Sciences 1988;546():1-8.
1988: Y Ishida; M Nishi; O Taguchi; K Inaba; Nagahiro Minato; M Kawaichi; Tasuku Honjo
Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice.
Princess Takamatsu symposia 1988;19():61-71.
1987: T Tanabe; M Konishi; T Mizuta; T Noma; Tasuku Honjo
Molecular cloning and structure of the human interleukin-5 gene.
The Journal of biological chemistry 1987;262(34):16580-4.
1987: Tasuku Honjo; Y Yaoita; T Kinashi; Y Noma; T Naito; C Azuma; Eva Severinson; P Sideras; S Bergstedt-Lindqvist; K Takatsu
Structure and function of interleukins 4 and 5.
Acta paediatrica Japonica; Overseas edition 1987;29(4):546-51.
1987: T Noma; T Mizuta; A Rosén; T Hirano; T Kishimoto; Tasuku Honjo
Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines.
Immunology letters 1987;15(3):249-53.
1987: Yutaka Tagaya; Y Taniguchi; M Naramura; M Okada; N Suzuki; H Kanamori; T Nikaido; Tasuku Honjo; Junji Yodoi
Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I(+) T cell lines.
Immunology letters 1987;15(3):221-8.
1987: T Kinashi; T Godal; Y Noma; N R Ling; Y Yaoita; Tasuku Honjo
Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes.
Genes & development 1987;1(5):465-70.
1987: N Harada; T Takahashi; M Matsumoto; T Kinashi; J Ohara; Y Kikuchi; N Koyama; Eva Severinson; Y Yaoita; Tasuku Honjo
Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(13):4581-5.
1987: K H Lee; Fumihiko MATSUDA; T Kinashi; M Kodaira; Tasuku Honjo
A novel family of variable region genes of the human immunoglobulin heavy chain.
Journal of molecular biology 1987;195(4):761-8.
1987: N Suzuki; N Matsunami; H Kanamori; N Ishida; A Shimizu; Y Yaoita; T Nikaido; Tasuku Honjo
The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts.
The Journal of biological chemistry 1987;262(11):5079-86.
1987: Hiroshi Miwa; T Uchida; T Kobayashi; Kenkichi Kita; S Shirakawa; Y Koyanagi; N Yamamoto; Akira Shimizu; Tasuku Honjo; M Hatanaka
Relationship of human cord blood mononuclear cell lines, established by the HTLV-I integration, to expression of T-cell phenotypes and the T-cell receptor gene rearrangement.
The Journal of molecular and cellular immunology : JMCI 1987;3(1):43-8.
1987: Hiroshi Miwa; H Konishi; N Kobayashi; Kenkichi Kita; S Shirakawa; Akira Shimizu; Tasuku Honjo; M Hatanaka
The T-cell receptor gene rearrangements in T-lineage tumors without OKT-3,4,6,8 markers.
The Journal of molecular and cellular immunology : JMCI 1987;3(1):37-42.
1986: M Kodaira; T Kinashi; I Umemura; Fumihiko MATSUDA; T Noma; Y Ono; Tasuku Honjo
Organization and evolution of variable region genes of the human immunoglobulin heavy chain.
Journal of molecular biology 1986;190(4):529-41.
1986: N Matsunami; H Siomi; M Hatanaka; Y Yaoita; Tasuku Honjo
Preferential transcription of HTLV-I LTR in cell-free extracts of human T cells producing HTLV-I viral proteins.
Nucleic acids research 1986;14(12):4779-86.
1983: Y Yaoita; N Matsunami; C Y Choi; H Sugiyama; T Kishimoto; Tasuku Honjo
The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene.
Nucleic acids research 1983;11(21):7303-16.