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Richard Honzatko

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Amino Acid Sequence

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Co-Publications
Name
56
Fromm, Herbert
17
Aleshin, Alexander
13
Poland, BW
10
Choe, Jun-Yong
10
Nelson, Scott
8
Iancu, Cristina
6
Hou, Zhenglin
6
Wang, Wenyan
5
Lipscomb, William
5
Borza, Tudor
4
Gorrell, Andrea
4
Hines, Justin
4
Svensson, Birte
3
Zeng, C
3
Nix, Jay

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Publications

TOP 3
Leung Daisy W; Ginder Nathaniel D; Nix Jay C; Basler Christopher F; Honzatko Richard B; Amarasinghe Gaya K
Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.
Leung Daisy W; Ginder Nathaniel D; Fulton D Bruce; Nix Jay; Basler Christopher F; Honzatko Richard B; Amarasinghe Gaya K
Structure of the Ebola VP35 interferon inhibitory domain.
Hines Justin K; Chen Xiaoming; Nix Jay C; Fromm Herbert J; Honzatko Richard B
Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition.

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All Publications

2009: Leung Daisy W; Ginder Nathaniel D; Nix Jay C; Basler Christopher F; Honzatko Richard B; Amarasinghe Gaya K
Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 2):163-5.
2009: Leung Daisy W; Ginder Nathaniel D; Fulton D Bruce; Nix Jay; Basler Christopher F; Honzatko Richard B; Amarasinghe Gaya K
Structure of the Ebola VP35 interferon inhibitory domain.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):411-6.
2007: Hines Justin K; Chen Xiaoming; Nix Jay C; Fromm Herbert J; Honzatko Richard B
Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition.
The Journal of biological chemistry 2007;282(49):36121-31.
2007: Hines Justin K; Kruesel Claire E; Fromm Herbert J; Honzatko Richard B
Structure of inhibited fructose-1,6-bisphosphatase from Escherichia coli: distinct allosteric inhibition sites for AMP and glucose 6-phosphate and the characterization of a gluconeogenic switch.
The Journal of biological chemistry 2007;282(34):24697-706.
2007: Hines Justin K; Fromm Herbert J; Honzatko Richard B
Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state.
The Journal of biological chemistry 2007;282(16):11696-704.
2006: Iancu Cristina V; Zhou Yang; Borza Tudor; Fromm Herbert J; Honzatko Richard B
Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetases.
Biochemistry 2006;45(38):11703-11.
2006: Ginder Nathaniel D; Binkowski Daniel J; Fromm Herbert J; Honzatko Richard B
Nucleotide complexes of Escherichia coli phosphoribosylaminoimidazole succinocarboxamide synthetase.
The Journal of biological chemistry 2006;281(30):20680-8.
2006: Hines Justin K; Fromm Herbert J; Honzatko Richard B
Novel allosteric activation site in Escherichia coli fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2006;281(27):18386-93.
2006: Lee Jin-Ha; Kang Hee-Kyoung; Moon Young-Hwan; Cho Dong Lyun; Kim Doman; Choe Jun-Yong; Honzatko R; Robyt John F
Cloning, expression and characterization of an extracellular enolase from Leuconostoc mesenteroides.
FEMS microbiology letters 2006;259(2):240-8.
2005: Skaff D Andrew; Kim Chang Sup; Tsai Henry J; Honzatko Richard B; Fromm Herbert J
Glucose 6-phosphate release of wild-type and mutant human brain hexokinases from mitochondria.
The Journal of biological chemistry 2005;280(46):38403-9.
2005: Iancu Cristina V; Mukund Susmith; Fromm Herbert J; Honzatko Richard B
R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2005;280(20):19737-45.
2005: Nelson Scott W; Binkowski Daniel J; Honzatko Richard B; Fromm Herbert J
Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
Biochemistry 2005;44(2):766-74.
2004: Nelson Scott W; Honzatko Richard B; Fromm Herbert J
Origin of cooperativity in the activation of fructose-1,6-bisphosphatase by Mg2+.
The Journal of biological chemistry 2004;279(18):18481-7.
2003: Choe Jun-Young; Nelson Scott W; Arienti Kristen L; Axe Frank U; Collins Tassie L; Jones Todd K; Kimmich Rachel D A; Newman Michael J; Norvell Karl; Ripka William C; Romano Suzanne J; Short Kevin M; Slee Deborah H; Fromm Herbert J; Honzatko Richard B
Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors.
The Journal of biological chemistry 2003;278(51):51176-83.
2003: Choe Jun-Yong; Nelson Scott W; Fromm Herbert J; Honzatko Richard B
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2003;278(18):16008-14.
2003: Choe Jun-Yong; Iancu Cristina V; Fromm Herbert J; Honzatko Richard B
Metaphosphate in the active site of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2003;278(18):16015-20.
2003: Aleshin Alexander E; Feng Ping-Hua; Honzatko Richard B; Reilly Peter J
Crystal structure and evolution of a prokaryotic glucoamylase.
Journal of molecular biology 2003;327(1):61-73.
2003: Borza Tudor; Iancu Cristina V; Pike Evan; Honzatko Richard B; Fromm Herbert J
Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance.
The Journal of biological chemistry 2003;278(9):6673-9.
2002: Iancu Cristina V; Borza Tudor; Fromm Herbert J; Honzatko Richard B
Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(43):40536-43.
2002: Iancu Cristina V; Borza Tudor; Fromm Herbert J; Honzatko Richard B
IMP, GTP, and 6-phosphoryl-IMP complexes of recombinant mouse muscle adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(30):26779-87.
2002: Nelson Scott W; Honzatko Richard B; Fromm Herbert J
Hybrid tetramers of porcine liver fructose-1,6-bisphosphatase reveal multiple pathways of allosteric inhibition.
The Journal of biological chemistry 2002;277(18):15539-45.
2002: Gorrell Andrea; Wang Wenyan; Underbakke Eric; Hou Zhenglin; Honzatko Richard B; Fromm Herbert J
Determinants of L-aspartate and IMP recognition in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 2002;277(11):8817-21.
2002: Hou Zhenglin; Wang Wenyan; Fromm Herbert J; Honzatko Richard B
IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
The Journal of biological chemistry 2002;277(8):5970-6.
2001: Wen J; Nelson S W; Honzatko R B; Fromm H J; Petrich J W
Environment of tryptophan 57 in porcine fructose-1,6-bisphosphatase studied by time-resolved fluorescence and site-directed mutagenesis.
Photochemistry and photobiology 2001;74(5):679-85.
2001: Iancu C V; Borza T; Choe J Y; Fromm H J; Honzatko R B
Recombinant mouse muscle adenylosuccinate synthetase: overexpression, kinetics, and crystal structure.
The Journal of biological chemistry 2001;276(45):42146-52.
2001: Nelson S W; Honzatko R B; Fromm H J
Spontaneous subunit exchange in porcine liver fructose-1,6-bisphosphatase.
FEBS letters 2001;492(3):254-8.
2001: Nelson S W; Kurbanov F T; Honzatko R B; Fromm H J
The N-terminal segment of recombinant porcine fructose-1,6-bisphosphatase participates in the allosteric regulation of catalysis.
The Journal of biological chemistry 2001;276(9):6119-24.
2000: Mallis R J; Poland B W; Chatterjee T K; Fisher R A; Darmawan S; Honzatko R B; Thomas J A
Crystal structure of S-glutathiolated carbonic anhydrase III.
FEBS letters 2000;482(3):237-41.
2000: Nelson S W; Iancu C V; Choe J Y; Honzatko R B; Fromm H J
Tryptophan fluorescence reveals the conformational state of a dynamic loop in recombinant porcine fructose-1,6-bisphosphatase.
Biochemistry 2000;39(36):11100-6.
2000: Nelson S W; Choe J Y; Honzatko R B; Fromm H J
Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase.
The Journal of biological chemistry 2000;275(39):29986-92.
2000: Choe J Y; Fromm H J; Honzatko R B
Crystal structures of fructose 1,6-bisphosphatase: mechanism of catalysis and allosteric inhibition revealed in product complexes.
Biochemistry 2000;39(29):8565-74.
2000: Aleshin A E; Kirby C; Liu X; Bourenkov G P; Bartunik H D; Fromm H J; Honzatko R B
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
Journal of molecular biology 2000;296(4):1001-15.
1999: Liu X; Kim C S; Kurbanov F T; Honzatko R B; Fromm H J
Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase.
The Journal of biological chemistry 1999;274(44):31155-9.
1999: Honzatko R B; Fromm H J
Structure-function studies of adenylosuccinate synthetase from Escherichia coli.
Archives of biochemistry and biophysics 1999;370(1):1-8.
1999: Aleshin A E; Malfois M; Liu X; Kim C S; Fromm H J; Honzatko R B; Koch M H; Svergun D I
Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution.
Biochemistry 1999;38(26):8359-66.
1999: Hou Z; Cashel M; Fromm H J; Honzatko R B
Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1999;274(25):17505-10.
1999: Choe J Y; Poland B W; Fromm H J; Honzatko R B
Mechanistic implications from crystalline complexes of wild-type and mutant adenylosuccinate synthetases from Escherichia coli.
Biochemistry 1999;38(21):6953-61.
1999: Honzatko R B; Stayton M M; Fromm H J
Adenylosuccinate synthetase: recent developments.
Advances in enzymology and related areas of molecular biology 1999;73():57-102, ix-x.
1998: Aleshin A E; Zeng C; Bartunik H D; Fromm H J; Honzatko R B
Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.
Journal of molecular biology 1998;282(2):345-57.
1998: Aleshin A E; Fromm H J; Honzatko R B
Multiple crystal forms of hexokinase I: new insights regarding conformational dynamics, subunit interactions, and membrane association.
FEBS letters 1998;434(1-2):42-6.
1998: Choe J Y; Poland B W; Fromm H J; Honzatko R B
Role of a dynamic loop in cation activation and allosteric regulation of recombinant porcine fructose-1,6-bisphosphatase.
Biochemistry 1998;37(33):11441-50.
1998: Fang T Y; Alechina O; Aleshin A E; Fromm H J; Honzatko R B
Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.
The Journal of biological chemistry 1998;273(31):19548-53.
1998: Kurbanov F T; Choe J Y; Honzatko R B; Fromm H J
Directed mutations in the poorly defined region of porcine liver fructose-1,6-bisphosphatase significantly affect catalysis and the mechanism of AMP inhibition.
The Journal of biological chemistry 1998;273(28):17511-6.
1998: Wang W; Gorrell A; Hou Z; Honzatko R B; Fromm H J
Ambiguities in mapping the active site of a conformationally dynamic enzyme by directed mutation. Role of dynamics in structure-function correlations in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1998;273(26):16000-4.
1998: Fang T Y; Honzatko R B; Reilly P J; Ford C
Mutations to alter Aspergillus awamori glucoamylase selectivity. II. Mutation of residues 119 and 121.
Protein engineering 1998;11(2):127-33.
1998: Aleshin A E; Zeng C; Bourenkov G P; Bartunik H D; Fromm H J; Honzatko R B
The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.
Structure (London, England : 1993) 1998;6(1):39-50.
1998: Zeng C; Aleshin A E; Chen G; Honzatko R B; Fromm H J
The roles of glycine residues in the ATP binding site of human brain hexokinase.
The Journal of biological chemistry 1998;273(2):700-4.
1997: Shyur L F; Poland B W; Honzatko R B; Fromm H J
Major changes in the kinetic mechanism of AMP inhibition and AMP cooperativity attend the mutation of Arg49 in fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1997;272(42):26295-9.
1997: Wang W; Hou Z; Honzatko R B; Fromm H J
Relationship of conserved residues in the IMP binding site to substrate recognition and catalysis in Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1997;272(27):16911-6.
1997: Poland B W; Bruns C; Fromm H J; Honzatko R B
Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli.
The Journal of biological chemistry 1997;272(24):15200-5.
1997: Kang C; Sun N; Poland B W; Gorrell A; Honzatko R B; Fromm H J
Residues essential for catalysis and stability of the active site of Escherichia coli adenylosuccinate synthetase as revealed by directed mutation and kinetics.
The Journal of biological chemistry 1997;272(18):11881-5.
1997: Wang W; Gorrell A; Honzatko R B; Fromm H J
A study of Escherichia coli adenylosuccinate synthetase association states and the interface residues of the homodimer.
The Journal of biological chemistry 1997;272(11):7078-84.
1996: Poland B W; Fromm H J; Honzatko R B
Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+.
Journal of molecular biology 1996;264(5):1013-27.
1996: Shyur L F; Aleshin A E; Honzatko R B; Fromm H J
Biochemical properties of mutant and wild-type fructose-1,6-bisphosphatases are consistent with the coupling of intra- and intersubunit conformational changes in the T- and R-state transition.
The Journal of biological chemistry 1996;271(52):33301-7.
1996: Poland B W; Lee S F; Subramanian M V; Siehl D L; Anderson R J; Fromm H J; Honzatko R B
Refined crystal structure of adenylosuccinate synthetase from Escherichia coli complexed with hydantocidin 5'-phosphate, GDP, HPO4(2-), Mg2+, and hadacidin.
Biochemistry 1996;35(49):15753-9.
1996: Aleshin A E; Zeng C; Fromm H J; Honzatko R B
Crystallization and preliminary X-ray analysis of human brain hexokinase.
FEBS letters 1996;391(1-2):9-10.
1996: Aleshin A E; Stoffer B; Firsov L M; Svensson B; Honzatko R B
Crystallographic complexes of glucoamylase with maltooligosaccharide analogs: relationship of stereochemical distortions at the nonreducing end to the catalytic mechanism.
Biochemistry 1996;35(25):8319-28.
1996: Poland B W; Hou Z; Bruns C; Fromm H J; Honzatko R B
Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
The Journal of biological chemistry 1996;271(26):15407-13.
1996: Shyur L F; Aleshin A E; Honzatko R B; Fromm H J
Site-directed mutagenesis of residues at subunit interfaces of porcine fructose-1,6-bisphosphatase.
The Journal of biological chemistry 1996;271(6):3005-10.
1995: Silva M M; Poland B W; Hoffman C R; Fromm H J; Honzatko R B
Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli.
Journal of molecular biology 1995;254(3):431-46.
1995: Frandsen T P; Christensen T; Stoffer B; Lehmbeck J; Dupont C; Honzatko R B; Svensson B
Mutational analysis of the roles in catalysis and substrate recognition of arginines 54 and 305, aspartic acid 309, and tryptophan 317 located at subsites 1 and 2 in glucoamylase from Aspergillus niger.
Biochemistry 1995;34(32):10162-9.
1995: Wang W; Poland B W; Honzatko R B; Fromm H J
Identification of arginine residues in the putative L-aspartate binding site of Escherichia coli adenylosuccinate synthetase.
The Journal of biological chemistry 1995;270(22):13160-3.
1995: Thomas J A; Poland B; Honzatko R
Protein sulfhydryls and their role in the antioxidant function of protein S-thiolation.
Archives of biochemistry and biophysics 1995;319(1):1-9.
1995: Stoffer B; Aleshin A E; Firsov L M; Svensson B; Honzatko R B
Refined structure for the complex of D-gluco-dihydroacarbose with glucoamylase from Aspergillus awamori var. X100 to 2.2 A resolution: dual conformations for extended inhibitors bound to the active site of glucoamylase.
FEBS letters 1995;358(1):57-61.
1994: Frandsen T P; Dupont C; Lehmbeck J; Stoffer B; Sierks M R; Honzatko R B; Svensson B
Site-directed mutagenesis of the catalytic base glutamic acid 400 in glucoamylase from Aspergillus niger and of tyrosine 48 and glutamine 401, both hydrogen-bonded to the gamma-carboxylate group of glutamic acid 400.
Biochemistry 1994;33(46):13808-16.
1994: Kang C; Sun N; Honzatko R B; Fromm H J
Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate.
The Journal of biological chemistry 1994;269(39):24046-9.
1994: Aleshin A E; Firsov L M; Honzatko R B
Refined structure for the complex of acarbose with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
The Journal of biological chemistry 1994;269(22):15631-9.
1994: Aleshin A E; Hoffman C; Firsov L M; Honzatko R B
Refined crystal structures of glucoamylase from Aspergillus awamori var. X100.
Journal of molecular biology 1994;238(4):575-91.
1993: Poland B W; Silva M M; Serra M A; Cho Y; Kim K H; Harris E M; Honzatko R B
Crystal structure of adenylosuccinate synthetase from Escherichia coli. Evidence for convergent evolution of GTP-binding domains.
The Journal of biological chemistry 1993;268(34):25334-42.
1993: Harris E M; Aleshin A E; Firsov L M; Honzatko R B
Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from Aspergillus awamori var. X100 to 2.4-A resolution.
Biochemistry 1993;32(6):1618-26.
1992: Aleshin A; Golubev A; Firsov L M; Honzatko R B
Crystal structure of glucoamylase from Aspergillus awamori var. X100 to 2.2-A resolution.
The Journal of biological chemistry 1992;267(27):19291-8.
1990: Cho Y J; Honzatko R B
Coordination complex of Na+ and alpha-D-glucose.
Acta crystallographica. Section C, Crystal structure communications 1990;46 ( Pt 4)():587-90.
1988: Ke H M; Lipscomb W N; Cho Y J; Honzatko R B
Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms.
Journal of molecular biology 1988;204(3):725-47.
1988: Serra M A; Bass M B; Fromm H J; Honzatko R B
Preliminary X-ray crystallographic study of adenylosuccinate synthetase from Escherichia coli.
Journal of molecular biology 1988;200(4):753-4.
1987: Kim K H; Honzatko R B; Little R M; Anderson P M
Preliminary X-ray crystallographic study of cyanase from Escherichia coli.
Journal of molecular biology 1987;198(1):137-8.
1987: Kim K H; Pan Z X; Honzatko R B; Ke H M; Lipscomb W N
Structural asymmetry in the CTP-liganded form of aspartate carbamoyltransferase from Escherichia coli.
Journal of molecular biology 1987;196(4):853-75.
1984: Ke H M; Honzatko R B; Lipscomb W N
Structure of unligated aspartate carbamoyltransferase of Escherichia coli at 2.6-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4037-40.
1982: Honzatko R B; Crawford J L; Monaco H L; Ladner J E; Ewards B F; Evans D R; Warren S G; Wiley D C; Ladner R C; Lipscomb W N
Crystal and molecular structures of native and CTP-liganded aspartate carbamoyltransferase from Escherichia coli.
Journal of molecular biology 1982;160(2):219-63.
1982: Ladner J E; Kitchell J P; Honzatko R B; Ke H M; Volz K W; Kalb A J; Ladner R C; Lipscomb W N
Gross quaternary changes in aspartate carbamoyltransferase are induced by the binding of N-(phosphonacetyl)-L-aspartate: A 3.5-A resolution study.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(10):3125-8.

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