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Ivan Horak

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Sandra Niendorf; Alexander Oksche; Agnes Kisser; Jürgen Löhler; Marco Prinz; Hubert Schorle; Stephan M Feller; Marc Lewitzky; Ivan Horak; Klaus-Peter Knobeloch
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.
Deborah J Lenschow; Caroline Lai; Natalia Frias-Staheli; Nadia V Giannakopoulos; Andrew Lutz; Thorsten Wolff; Anna Osiak; Beth Levine; Robert E Schmidt; Adolfo García-Sastre; David A Leib; Andrew Pekosz; Klaus-Peter Knobeloch; Ivan Horak; Herbert W Virgin
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Klaus-Peter Knobeloch; Olaf Utermöhlen; Agnes Kisser; Marco Prinz; Ivan Horak
Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.

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2007: Sandra Niendorf; Alexander Oksche; Agnes Kisser; Jürgen Löhler; Marco Prinz; Hubert Schorle; Stephan M Feller; Marc Lewitzky; Ivan Horak; Klaus-Peter Knobeloch
Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.
Molecular and cellular biology 2007;27(13):5029-39.
2007: Deborah J Lenschow; Caroline Lai; Natalia Frias-Staheli; Nadia V Giannakopoulos; Andrew Lutz; Thorsten Wolff; Anna Osiak; Beth Levine; Robert E Schmidt; Adolfo García-Sastre; David A Leib; Andrew Pekosz; Klaus-Peter Knobeloch; Ivan Horak; Herbert W Virgin
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(4):1371-6.
2005: Klaus-Peter Knobeloch; Olaf Utermöhlen; Agnes Kisser; Marco Prinz; Ivan Horak
Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.
Molecular and cellular biology 2005;25(24):11030-4.
2005: Anna Osiak; Olaf Utermöhlen; Sandra Niendorf; Ivan Horak; Klaus-Peter Knobeloch
ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus.
Molecular and cellular biology 2005;25(15):6338-45.
2005: Christina Osswald; Katharina Baumgarten; Frank Stümpel; Valentin Gorboulev; Marina Akimjanova; Klaus-Peter Knobeloch; Ivan Horak; Reinhart Kluge; Hans-Georg Joost; Hermann Koepsell
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.
Molecular and cellular biology 2005;25(1):78-87.
2004: Christian Barmeyer; M Harren; Heinz Schmitz; U Heinzel-Pleines; Joachim Mankertz; U Seidler; Ivan Horak; Bertram Wiedenmann; Michael Fromm; Jörg-Dieter Schulzke
Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(2):G244-52.
2003: Miriam Zat'ovicová; Kvetoslava Tarábková; Eliska Svastová; Adriana Gibadulinová; Vojtech Mucha; Lýdia Jakubícková; Zuzana Biesová; Monika Rafajová; Marta Ortova Gut; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Willam S Sly; Ivan Horak; Jaromir Pastorek; Silvia Pastoreková
Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX.
Journal of immunological methods 2003;282(1-2):117-34.
2002: Marta Gut; Seppo Parkkila; Zdeòka Vernerová; Elvira Rohde; Jan Závada; Michael Höcker; Jaromir Pastorek; Tuomo J Karttunen; Adriana Gibadulinová; Zuzana Závadová; Klaus-Peter Knobeloch; Bertram Wiedenmann; Jan Svoboda; Ivan Horak; Silvia Pastoreková
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9.
Gastroenterology 2002;123(6):1889-903.
2002: Zane Orinska; Anna Osiak; Jürgen Löhler; Elena Bulanova; Vadim Budagian; Ivan Horak; Silvia Bulfone-Paus
Novel B cell population producing functional IgG in the absence of membrane IgM expression.
European journal of immunology 2002;32(12):3472-80.
2002: Maike Schwieger; Jürgen Löhler; Jutta Friel; Marina Scheller; Ivan Horak; Carol Stocking
AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency.
The Journal of experimental medicine 2002;196(9):1227-40.
2002: Axel Kallies; Frank Rosenbauer; Marina Scheller; Klaus-Peter Knobeloch; Ivan Horak
Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages.
Blood 2002;99(9):3213-9.
2002: Martina Schwarzkopf; Klaus-Peter Knobeloch; Elvira Rohde; Stephan Hinderlich; Nicola Wiechens; Lothar Lucka; Ivan Horak; Werner Reutter; Rüdiger Horstkorte
Sialylation is essential for early development in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(8):5267-70.
2002: Frank Rosenbauer; Axel Kallies; Marina Scheller; Klaus-Peter Knobeloch; Charles O Rock; Maike Schwieger; Carol Stocking; Ivan Horak
Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.
The EMBO journal 2002;21(3):211-20.
2002: Christian Barmeyer; Ivan Horak; Martin Zeitz; Michael Fromm; Jörg-Dieter Schulzke
The interleukin-2-deficient mouse model.
Pathobiology : journal of immunopathology, molecular and cellular biology 2002;70(3):139-42.
2000: Klaus-Peter Knobeloch; Mark D Wright; A F Ochsenbein; O Liesenfeld; Jürgen Löhler; Rolf M Zinkernagel; Ivan Horak; Zane Orinska
Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.
Molecular and cellular biology 2000;20(15):5363-9.
2000: M Harren; Christian Barmeyer; Heinz Schmitz; Michael Fromm; Ivan Horak; A Dignass; M John; Bertram Wiedenmann; Jörg-Dieter Schulzke
Enhanced expression of iNOS in inflamed colons of IL-2-deficient mice does not impair colonic epithelial barrier function.
Annals of the New York Academy of Sciences 2000;915():204-13.
1999: Frank Rosenbauer; JF Waring; John Foerster; M Wietstruk; D Philipp; Ivan Horak
Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages.
Blood 1999;94(12):4274-81.
1999: Marina Scheller; John Foerster; Clare Heyworth; JF Waring; Jürgen Löhler; GL Gilmore; Richard K Shadduck; TM Dexter; Ivan Horak
Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein.
Blood 1999;94(11):3764-71.
1999: W Hauser; Klaus-Peter Knobeloch; Martin Eigenthaler; Stepan Gambaryan; Veit Krenn; Joerg Geiger; Margarita Glazova; Elvira Rohde; Ivan Horak; Ulrich Walter; Michael Zimmer
Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8120-5.
1998: M Harren; Gilbert Schönfelder; Martin Paul; Ivan Horak; Ernst-Otto Riecken; Bertram Wiedenmann; M John
High expression of inducible nitric oxide synthase correlates with intestinal inflammation of interleukin-2-deficient mice.
Annals of the New York Academy of Sciences 1998;859():210-5.
1998: M Schmidt; S Nagel; J Proba; Christian Thiede; M Ritter; JF Waring; Frank Rosenbauer; D Huhn; Burghardt Wittig; Ivan Horak; A Neubauer
Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.
Blood 1998;91(1):22-9.
1996: G Klebb; Ingo B Autenrieth; H Haber; E Gillert; B Sadlack; Kendall A Smith; Ivan Horak
Interleukin-2 is indispensable for development of immunological self-tolerance.
Clinical immunology and immunopathology 1996;81(3):282-6.
1996: T Holtschke; J Löhler; Y Kanno; Thomas Fehr; N Giese; Frank Rosenbauer; J Lou; K P Knobeloch; Lucia Gabriele; J F Waring; Martin F Bachmann; Rolf M Zinkernagel; Herbert C Morse; Keiko Ozato; Ivan Horak
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
Cell 1996;87(2):307-17.
1996: B Funke; B Zuleger; Ricardo Benavente; T Schuster; M Goller; J Stévenin; Ivan Horak
The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.
Nucleic acids research 1996;24(19):3821-8.
1996: R R Tschopp; Sebastian Brandner; S Marino; K Bothe; Ivan Horak; Axel Rethwilm; Adriano Aguzzi
Analysis of the determinants of neurotropism and neurotoxicity of HFV in transgenic mice.
Virology 1996;216(2):338-46.
1995: Ivan Horak; J Löhler; A Ma; Kendall A Smith
Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance.
Immunological reviews 1995;148():35-44.
1995: B Sadlack; J Löhler; H Schorle; G Klebb; H Haber; E Sickel; R J Noelle; Ivan Horak
Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.
European journal of immunology 1995;25(11):3053-9.
1995: Ivan Horak
Immunodeficiency in IL-2-knockout mice.
Clinical immunology and immunopathology 1995;76(3 Pt 2):S172-3.
1995: Martin F Bachmann; H Schorle; R Kühn; Werner Muller; Hans Hengartner; Rolf M Zinkernagel; Ivan Horak
Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
Journal of virology 1995;69(8):4842-6.
1994: S Krämer; Clio Mamalaki; Ivan Horak; Anneliese Schimpl; Dimitris Kioussis; T Hüng
Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice.
European journal of immunology 1994;24(10):2317-22.
1994: M Goller; B Funke; C Gehe-Becker; B Kröger; F Lottspeich; Ivan Horak
Murine protein which binds preferentially to oligo-C-rich single-stranded nucleic acids.
Nucleic acids research 1994;22(10):1885-9.
1994: Klaus J Erb; T Holtschke; K Muth; Ivan Horak; Anneliese Schimpl
T cell subset distribution and B cell hyperreactivity in mice expressing interleukin-4 under the control of major histocompatibility complex class I regulatory sequences.
European journal of immunology 1994;24(5):1143-7.
1994: B Sadlack; R Kühn; H Schorle; K Rajewsky; Werner Muller; Ivan Horak
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
European journal of immunology 1994;24(1):281-4.
1993: TM Kündig; H Schorle; Martin F Bachmann; Hans Hengartner; Rolf M Zinkernagel; Ivan Horak
Immune responses in interleukin-2-deficient mice.
Science (New York, N.Y.) 1993;262(5136):1059-61.
1993: B Sadlack; H Merz; H Schorle; Anneliese Schimpl; A C Feller; Ivan Horak
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene.
Cell 1993;75(2):253-61.
1992: Adriano Aguzzi; K Bothe; I Anhauser; Ivan Horak; Axel Rethwilm; E F Wagner
Expression of human foamy virus is differentially regulated during development in transgenic mice.
The New biologist 1992;4(3):225-37.
1992: Adriano Aguzzi; K Bothe; E F Wagner; Axel Rethwilm; Ivan Horak
Human foamy virus: an underestimated neuropathogen?
Brain pathology (Zurich, Switzerland) 1992;2(1):61-9.
1991: H Schorle; T Holtschke; Thomas Hünig; Anneliese Schimpl; Ivan Horak
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting.
Nature 1991;352(6336):621-4.
1991: K Bothe; Adriano Aguzzi; H Lassmann; Axel Rethwilm; Ivan Horak
Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes.
Science (New York, N.Y.) 1991;253(5019):555-7.
1989: Winfried Edelmann; B Kröger; M Goller; Ivan Horak
A recombination hotspot in the LTR of a mouse retrotransposon identified in an in vitro system.
Cell 1989;57(6):937-46.
1988: T Baumruker; C Gehe; Ivan Horak
Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal.
Nucleic acids research 1988;16(15):7241-51.
1987: B Kröger; Ivan Horak
Isolation of novel human retrovirus-related sequences by hybridization to synthetic oligonucleotides complementary to the tRNA(Pro) primer-binding site.
Journal of virology 1987;61(7):2071-5.
1985: M Schmidt; T Wirth; B Kröger; Ivan Horak
Structure and genomic organization of a new family of murine retrovirus-related DNA sequences (MuRRS).
Nucleic acids research 1985;13(10):3461-70.
1984: M Schmidt; K Glöggler; T Wirth; Ivan Horak
Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).
Proceedings of the National Academy of Sciences of the United States of America 1984;81(21):6696-700.
1984: T Wirth; M Schmidt; T Baumruker; Ivan Horak
Evidence for mobility of a new family of mouse middle repetitive DNA elements (LTR-IS).
Nucleic acids research 1984;12(8):3603-10.
1983: T Wirth; K Glöggler; T Baumruker; M Schmidt; Ivan Horak
Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(11):3327-30.
1982: D Klenner; Ivan Horak; Anneliese Schimpl; E Wecker
Expression of endogenous retroviral glycoprotein 70 by antigen-activated cytotoxic and suppressor T lymphocytes of nice.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1250-3.
1982: E Wecker; Ivan Horak
Expression of endogenous viral genes in mouse lymphocytes.
Current topics in microbiology and immunology 1982;98():27-36.