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Yasuo Horie

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Shunsuke Takasuga; Yoh Wada; Masakazu Yamazaki; Yoshiko Sato; Ge-Hong Sun-Wada; Akira Suzuki; Shinsuke Chida; Satoshi Eguchi; Akihiro Harada; Chihoko Horie; Yasuo Horie; Ryota Iizuka; Toshiaki Katada; Nobuyuki Kawamura; Hirotaka Kimura; Satoshi Kofuji; Kenji Kontani; Katsunori Mizuno; Eri Odanaga; Hirohide Ohnishi; Junko Sasaki; Takehiko Sasaki
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.
Masahiro Iizuka; Osamu Nakagomi; Hiroshi Nanjo; Shiho Sagara; Akira Sugita; Mitsuro Chiba; Tsuneo Fukushima; Yasuo Horie; Sumio Watanabe
Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.
Hirosato Mashima; Yuko Nakagawa; Yasuo Horie; Itaru Kojima; Toshiaki Ohteki; Taku Sato; Hirohide Ohnishi
Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.

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All Publications

2013: Shunsuke Takasuga; Yoh Wada; Masakazu Yamazaki; Yoshiko Sato; Ge-Hong Sun-Wada; Akira Suzuki; Shinsuke Chida; Satoshi Eguchi; Akihiro Harada; Chihoko Horie; Yasuo Horie; Ryota Iizuka; Toshiaki Katada; Nobuyuki Kawamura; Hirotaka Kimura; Satoshi Kofuji; Kenji Kontani; Katsunori Mizuno; Eri Odanaga; Hirohide Ohnishi; Junko Sasaki; Takehiko Sasaki
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1726-31.
2012: Masahiro Iizuka; Osamu Nakagomi; Hiroshi Nanjo; Shiho Sagara; Akira Sugita; Mitsuro Chiba; Tsuneo Fukushima; Yasuo Horie; Sumio Watanabe
Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.
Journal of gastroenterology and hepatology 2012;27(8):1388-94.
2011: Hirosato Mashima; Yuko Nakagawa; Yasuo Horie; Itaru Kojima; Toshiaki Ohteki; Taku Sato; Hirohide Ohnishi
Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.
Gastroenterology 2011;141(3):1102-1113.e1-8.
2011: Masato Sasaki; Takehiko Sasaki; Jia Wang; Takayuki Yamashita; Yong Ryoul Yang; Yanping Zhang; Yan Zhu; Koichi Hamada; Hiroki Hikasa; Yasuo Horie; Bunsho Itoh; Takehiko Kamijo; Kohichi Kawahara; Ryunosuke Kogo; Yukako Komatsu; Tomohiko Maehama; Tak Wah Mak; Koshi Mimori; Masaki Mori; Toru Nakano; Miki Nishio; Carol Prives; Akira Suzuki
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.
Nature medicine 2011;17(8):944-51.
2011: Nobukatsu Kinoshita; Yasuo Horie; Shigetoshi Ohshima; Yohei Hirai; Takahiro Dohmen; Mario Jin; Tamotsu Matsuhashi; Junko Sasaki; Takehiko Sasaki; Masahiro Iizuka; Hirohide Ohnishi
Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury.
Journal of gastroenterology and hepatology 2011;26(1):201-6.
2010: Jumpei Asano; Hiroyuki Tada; Nobuyuki Onai; Taku Sato; Yasuo Horie; Yukari Fujimoto; Koichi Fukase; Akira Suzuki; Tak W Mak; Toshiaki Ohteki
Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):736-45.
2009: Yumiko Anezaki; Shigetoshi Ohshima; Hajime Ishii; Nobukatsu Kinoshita; Takahiro Dohmen; Ei Kataoka; Wataru Sato; Masahiro Iizuka; Takashi Goto; Junko Sasaki; Takehiko Sasaki; Akira Suzuki; Hirohide Ohnishi; Yasuo Horie
Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(6):609-18.
2009: Hajime Ishii; Yasuo Horie; Shigetoshi Ohshima; Yumiko Anezaki; Nobukatsu Kinoshita; Takahiro Dohmen; Ei Kataoka; Wataru Sato; Takashi Goto; Junko Sasaki; Takehiko Sasaki; Sumio Watanabe; Akira Suzuki; Hirohide Ohnishi
Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice.
Journal of hepatology 2009;50(3):562-71.
2008: Shoko Kuroda; Miki Nishio; Takehiko Sasaki; Yasuo Horie; Koichi Kawahara; Masato Sasaki; Miyuki Natsui; Takashi Matozaki; Hiroyuki Tezuka; Toshiaki Ohteki; Irmgard Förster; Tak W Mak; Toru Nakano; Akira Suzuki
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages.
European journal of immunology 2008;38(5):1331-40.
2007: Shigehisa Yanagi; Hiroyuki Kishimoto; Kohichi Kawahara; Takehiko Sasaki; Masato Sasaki; Miki Nishio; Nobuyuki Yajima; Koichi Hamada; Yasuo Horie; Hiroshi Kubo; Jeffrey A Whitsett; Tak Wah Mak; Toru Nakano; Masamitsu Nakazato; Akira Suzuki
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
The Journal of clinical investigation 2007;117(10):2929-40.
2007: Sumio Watanabe; Yasuo Horie; Ei Kataoka; Wataru Sato; Takahiro Dohmen; Shigetoshi Ohshima; Takashi Goto; Akira Suzuki
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice.
Journal of gastroenterology and hepatology 2007;22 Suppl 1():S96-S100.
2007: Hiroyuki Kishimoto; Toshiaki Ohteki; Nobuyuki Yajima; Koichi Kawahara; Miyuki Natsui; Satoru Kawarasaki; Koichi Hamada; Yasuo Horie; Yoshiaki Kubo; Seiji Arase; Masaru Taniguchi; Bart Vanhaesebroeck; Tak Wah Mak; Toru Nakano; Shigeo Koyasu; Takehiko Sasaki; Akira Suzuki
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.
Blood 2007;109(8):3316-24.
2007: Miki Nishio; Ken-ichi Watanabe; Junko Sasaki; Choji Taya; Shunsuke Takasuga; Ryota Iizuka; Tamas Balla; Masakazu Yamazaki; Hiroshi Watanabe; Reietsu Itoh; Shoko Kuroda; Yasuo Horie; Irmgard Förster; Tak W Mak; Hiromichi Yonekawa; Josef M Penninger; Yasunori Kanaho; Akira Suzuki; Takehiko Sasaki
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
Nature cell biology 2007;9(1):36-44.
2007: Masahiro Iizuka; Kenji Sasaki; Yohei Hirai; Kenichi Shindo; Shiho Konno; Hiroaki Itou; Shigetoshi Ohshima; Yasuo Horie; Sumio Watanabe
Morphogenic protein epimorphin protects intestinal epithelial cells from oxidative stress by the activation of EGF receptor and MEK/ERK, PI3 kinase/Akt signals.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(1):G39-52.
2006: Hiroshi Tsuruta; Hiroyuki Kishimoto; Takehiko Sasaki; Yasuo Horie; Miyuki Natsui; Yoshiko Shibata; Koichi Hamada; Nobuyuki Yajima; Koichi Kawahara; Masato Sasaki; Norihiko Tsuchiya; Katsuhiko Enomoto; Tak Wah Mak; Toru Nakano; Tomonori Habuchi; Akira Suzuki
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.
Cancer research 2006;66(17):8389-96.
2006: Yasuo Horie; Shigetoshi Ohshima; Wataru Sato; Akira Suzuki; Sumio Watanabe
[Hepatocyte-specific Pten deficient mice].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(6):1033-42.
2006: Kenichi Shindo; Masahiro Iizuka; Kenji Sasaki; Shiho Konno; Hiroaki Itou; Yasuo Horie; Sumio Watanabe
Sucralfate prevents the delay of wound repair in intestinal epithelial cells by hydrogen peroxide through NF-kappaB pathway.
Journal of gastroenterology 2006;41(5):450-61.
2006: Wataru Sato; Yasuo Horie; Ei Kataoka; Shigetoshi Ohshima; Takahiro Dohmen; Masahiro Iizuka; Junko Sasaki; Takehiko Sasaki; Koichi Hamada; Hiroyuki Kishimoto; Akira Suzuki; Sumio Watanabe
Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge.
Hepatology research : the official journal of the Japan Society of Hepatology 2006;34(4):256-65.
2006: Akiko Sato; Masahiro Iizuka; Osamu Nakagomi; Manabu Suzuki; Yasuo Horie; Shiho Konno; Fujiko Hirasawa; Kenji Sasaki; Kenichi Shindo; Sumio Watanabe
Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cells.
Journal of gastroenterology and hepatology 2006;21(3):521-30.
2006: Yasuo Horie; Ei Kataoka; Shigetoshi Oshima; Wataru Sato; Takahiro Domen; Sumio Watanabe; Akira Suzuki
[Non-alcoholic steatohepatitis (NASH). 4. Physiopathological explanation (a lesson from experimental models)].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2006;95(1):57-65.
2005: Sumio Watanabe; Yasuo Horie; Akira Suzuki
Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma.
Hepatology research : the official journal of the Japan Society of Hepatology 2005;33(2):161-6.
2005: Koichi Hamada; Takehiko Sasaki; Pandelakis Koni; Miyuki Natsui; Hiroyuki Kishimoto; Junko Sasaki; Nobuyuki Yajima; Yasuo Horie; Go Hasegawa; Makoto Naito; Jun-Ichi Miyazaki; Toshio Suda; Hiroshi Itoh; Kazuwa Nakao; Tak Wah Mak; Toru Nakano; Akira Suzuki
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Genes & development 2005;19(17):2054-65.
2005: Wataru Sato; Yasuo Horie; Sumio Watanabe; Akira Suzuki
[Tumor suppressor gene PTEN and non-alcoholic steatohepatitis (NASH)].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(8):1475-83.
2005: Yasuo Horie; Akira Suzuki; Ei Kataoka; Takashi Goto; Ryutaro Yoshino; Wataru Sato; Sumio Watanabe
[From fatty liver to liver cancer--new development in non-alcoholic steatohepatitis (NASH) using animal models].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2005;94(5):990-8.
2005: Kenji Sasaki; Masahiro Iizuka; Shiho Konno; Kenichi Shindo; Akiko Sato; Yasuo Horie; Sumio Watanabe
Ecabet sodium prevents the delay of wound repair in intestinal epithelial cells induced by hydrogen peroxide.
Journal of gastroenterology 2005;40(5):474-82.
2004: Shiho Konno; Masahiro Iizuka; Michihiro Yukawa; Kenji Sasaki; Akiko Sato; Yasuo Horie; Hiroshi Nanjo; Tsuneo Fukushima; Sumio Watanabe
Altered expression of angiogenic factors in the VEGF-Ets-1 cascades in inflammatory bowel disease.
Journal of gastroenterology 2004;39(10):931-9.
2004: Masahiro Iizuka; Hiroaki Itou; Shiho Konno; Junichi Chihara; M Tobita; Hajime Oyamada; Itaru Toyoshima; Kenji Sasaki; Akiko Sato; Yasuo Horie; Sumio Watanabe
Elemental diet modulates the growth of Clostridium difficile in the gut flora.
Alimentary pharmacology & therapeutics 2004;20 Suppl 1():151-7.
2004: Yasuo Horie; Akira Suzuki; Ei Kataoka; Takehiko Sasaki; Koichi Hamada; Junko Sasaki; Katsunori Mizuno; Go Hasegawa; Hiroyuki Kishimoto; Masahiro Iizuka; Makoto Naito; Katsuhiko Enomoto; Sumio Watanabe; Tak Wah Mak; Toru Nakano
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas.
The Journal of clinical investigation 2004;113(12):1774-83.
2004: Masahiro Iizuka; Shiho Konno; Hiroaki Itou; Junichi Chihara; Itaru Toyoshima; Yasuo Horie; Kenji Sasaki; Akiko Sato; Kenichi Shindo; Sumio Watanabe
Novel evidence suggesting Clostridium difficile is present in human gut microbiota more frequently than previously suspected.
Microbiology and immunology 2004;48(11):889-92.
2003: Tomoyuki Shirasaka; Masahiro Iizuka; Michihiro Yukawa; Yohei Hirai; Yasuo Horie; Hiroaki Itou; Shiho Kon-No; Tsuneo Fukushima; Sumio Watanabe
Altered expression of epimorphin in ulcerative colitis.
Journal of gastroenterology and hepatology 2003;18(5):570-7.
2002: Michihiro Yukawa; Masahiro Iizuka; Yasuo Horie; Kazuo Yoneyama; Tomoyuki Shirasaka; Hiroaki Itou; Masafumi Komatsu; Tsuneo Fukushima; Sumio Watanabe
Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis.
International journal of colorectal disease 2002;17(2):70-6.
2001: S Sasaki; Yasuo Horie; Toyoko Nakagomi; M Oseto; Osamu Nakagomi
Group C rotavirus NSP4 induces diarrhea in neonatal mice.
Archives of virology 2001;146(4):801-6.
1999: Yasuo Horie; Osamu Nakagomi; Y Koshimura; Toyoko Nakagomi; Y Suzuki; T Oka; S Sasaki; Y Matsuda; Sumio Watanabe
Diarrhea induction by rotavirus NSP4 in the homologous mouse model system.
Virology 1999;262(2):398-407.
1999: Hiroaki Itou; Masahiro Iizuka; Michihiro Yukawa; Yasuo Horie; M Chiba; Sumio Watanabe; O Masamune
[Five cases of detected fecal Clostridium difficile toxin during elemental diet].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1999;96(7):834-9.
1999: Toyoko Nakagomi; Yasuo Horie; Y Koshimura; Harry B Greenberg; Osamu Nakagomi
Isolation of a human rotavirus strain with a super-short RNA pattern and a new P2 subtype.
Journal of clinical microbiology 1999;37(4):1213-6.
1998: M Chiba; Tsuneo Fukushima; Yasuo Horie; Masahiro Iizuka; O Masamune
No Mycobacterium paratuberculosis detected in intestinal tissue, including Peyer's patches and lymph follicles, of Crohn's disease.
Journal of gastroenterology 1998;33(4):482-7.
1998: Yasuo Horie; M Chiba; T Suzuki; T Kudo; A Kamata; Masahiro Iizuka; O Masamune
Induction of major histocompatibility complex class II antigens on human colonic epithelium by interferon-gamma, tumor necrosis factor-alpha, and interleukin-2.
Journal of gastroenterology 1998;33(1):39-47.
1997: M Chiba; Masahiro Iizuka; Yasuo Horie; O Masamune
Metastatic Crohn's disease involving the penis.
Journal of gastroenterology 1997;32(6):817-21.
1997: Yasuo Horie; M Chiba; Kouichi Miura; Masahiro Iizuka; O Masamune; A Komatsuda; T Ebina
Crohn's disease associated with renal amyloidosis successfully treated with an elemental diet.
Journal of gastroenterology 1997;32(5):663-7.
1997: Yasuo Horie; O Masamune; Osamu Nakagomi
Three major alleles of rotavirus NSP4 proteins identified by sequence analysis.
The Journal of general virology 1997;78 ( Pt 9)():2341-6.
1997: A Kamata; M Chiba; N Ishii; T Kudo; Yasuo Horie; Masahiro Iizuka; O Masamune
Three cases of familial ulcerative colitis--in a mother and two of her sons.
Journal of gastroenterology 1997;32(3):401-4.
1997: Yasuo Horie; Toyoko Nakagomi; M Oseto; O Masamune; Osamu Nakagomi
Conserved structural features of nonstructural glycoprotein NSP4 between group A and group C rotaviruses.
Archives of virology 1997;142(9):1865-72.
1995: M Chiba; Masahiro Iizuka; Yasuo Horie; N Ishii; T Suzuki; O Masamune
Further studies of HLA-DR antigens on colonic epithelium in ulcerative colitis.
The Tohoku journal of experimental medicine 1995;177(2):161-70.
1995: K Miura; Yasuo Horie; M Chiba; O Masamune; Ryuji Sashi; M Niwa; N Ishii
[A case of Crohn's disease with a complication of thrombosis in the inferior vena cava].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1995;92(7):1076-81.
1995: A Kamata; M Chiba; Yasuo Horie; O Masamune; T Yoshida; S Takahashi
[A case of digestive fract T-cell malignant lymphoma with clinical course of twenty years].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 1995;92(5):879-84.
1991: Yasuo Horie; M Chiba; Masahiro Iizuka; O Masamune
Class II (HLA-DR, HLA-DP, and HLA-DQ) antigens on colonic epithelia in ulcerative colitis: a comparison between uneventful and intractable cases.
The Tohoku journal of experimental medicine 1991;165(2):87-97.
1990: Masahiro Iizuka; M Chiba; Yasuo Horie; O Masamune; H Ohta
Lymphoid cell subsets in colonic mucosa and HLA-DR antigens on colonic epithelia in colitis excluding ulcerative colitis and Crohn's disease.
Gastroenterologia Japonica 1990;25(6):700-7.
1990: Yasuo Horie; M Chiba; Masahiro Iizuka; O Masamune
Class II (HLA-DR, -DP, and -DO) antigens on intestinal epithelia in ulcerative colitis, Crohn's disease, colorectal cancer and normal small intestine.
Gastroenterologia Japonica 1990;25(5):575-84.
1990: Yasuo Horie; M Chiba; Masahiro Iizuka; K Igarashi; O Masamune
HLA antigens on colorectal adenoma and cancer cells.
The Tohoku journal of experimental medicine 1990;160(4):311-22.
1989: Yasuo Horie; M Chiba; Masahiro Iizuka; K Igarashi; O Masamune
Colonic lymphoid cell subsets and epithelial HLA-DR antigens in familial polyposis coli.
Gastroenterologia Japonica 1989;24(6):632-9.
1989: M Chiba; Masahiro Iizuka; Yasuo Horie; K Igarashi; O Masamune
HLA-DR antigen expression in macroscopically uninvolved areas of intestinal epithelia in Crohn's disease.
Gastroenterologia Japonica 1989;24(4):365-72.