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Akira Horii

Research Profile

Disorders

Genes & Molecular Sequences

Genes, Tumor Suppressor

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Shinichi Fukushige; Akira Horii
DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers.
Hitoshi Sekine; Makoto Sunamura; Yukiko Umetsu; Yuki Yoshino; Na Chen; Shinichi Fukushige; Zhaodi Gu; Guo Jin; Hiroki Nagase; Yuriko Saiki; Keisuke Sato; Akira Horii
S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells.
Takenori Ogawa; Shigeru Saijo; Yuriko Saiki; Kiyoto Shiga; Makoto Sunamura; Na Chen; Shinichi Fukushige; Sho Hashimoto; Toshimitsu Kobayashi; Kazuto Matsuura; Hiroki Nagase; Akira Horii
miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.

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All Publications

2013: Shinichi Fukushige; Akira Horii
DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers.
The Tohoku journal of experimental medicine 2013;229(3):173-85.
2012: Hitoshi Sekine; Makoto Sunamura; Yukiko Umetsu; Yuki Yoshino; Na Chen; Shinichi Fukushige; Zhaodi Gu; Guo Jin; Hiroki Nagase; Yuriko Saiki; Keisuke Sato; Akira Horii
S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells.
Biochemical and biophysical research communications 2012;429(3-4):214-9.
2012: Takenori Ogawa; Shigeru Saijo; Yuriko Saiki; Kiyoto Shiga; Makoto Sunamura; Na Chen; Shinichi Fukushige; Sho Hashimoto; Toshimitsu Kobayashi; Kazuto Matsuura; Hiroki Nagase; Akira Horii
miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.
Cancer science 2012;103(9):1737-43.
2012: Yuriko Saiki; Miki Shimada; Hideyuki Shimizu; Shinjiro Shimizu; Makoto Sunamura; Michiaki Unno; Yuki Yoshino; Na Chen; Shinichi Egawa; Hiroko Fujimura; Sho Fujiwara; Shinichi Fukushige; Masaharu Ishida; Guo Jin; Yuki Kudo; Yoonha Lee; Tatsuya Manabe; Nariyasu Mano; Fuyuhiko Motoi; Tomohiro Nakano; Zhaleh Kashkouli Nezhad; Shinya Oba; Akira Horii
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochemical and biophysical research communications 2012;421(1):98-104.
2012: Kentaro Shima; Shinichi Egawa; Hiroki Hayashi; Akira Horii; Naoto Ishii; Yu Katayose; Yo Kitamura; Masamichi Mizuma; Fuyuhiko Motoi; Kei Nakagawa; Takaho Okada; Noriyuki Omura; Toshiki Rikiyama; Naoaki Sakata; Michiaki Unno
Potential utility of eGFP-expressing NOG mice (NOG-EGFP) as a high purity cancer sampling system.
Journal of experimental & clinical cancer research : CR 2012;31():55.
2011: Hideyuki Shimizu; Makoto Sunamura; Michiaki Unno; Shinichi Egawa; Akira Horii; Fuyuhiko Motoi; Shinichi Fukushige
Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array).
Biochemical and biophysical research communications 2011;411(1):162-7.
2011: Yuriko Saiki; Kiyoto Shiga; Makoto Sunamura; Toshimitsu Kobayashi; Takenori Ogawa; Akira Horii
A Human Head and Neck Squamous Cell Carcinoma Cell Line with Acquired cis-Diamminedichloroplatinum-Resistance Shows Remarkable Upregulation of BRCA1 and Hypersensitivity to Taxane.
International journal of otolaryngology 2011;2011():521852.
2010: Takenori Ogawa; Kazumi Ogawa; Kiyoto Shiga; Toru Furukawa; Hiroki Nagase; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii
Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2010;267(10):1599-606.
2010: Takenori Ogawa; Toru Furukawa; Kiyoto Shiga; Sho Hashimoto; Kazumi Ogawa; Toshimitsu Kobayashi; Akira Horii
A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2010;267(1):123-9.
2009: Naoyuki Kaneko; Koh Miura; Zhaodi Gu; Hideaki Karasawa; Shinobu Ohnuma; Hiroyuki Sasaki; Nobukazu Tsukamoto; Satoru Yokoyama; Akihiro Yamamura; Hiroki Nagase; Chikashi Shibata; Iwao Sasaki; Akira Horii
siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.
Biochemical and biophysical research communications 2009;390(4):1235-40.
2009: Takahiro Tabata; Nobukazu Tsukamoto; Abbas Ali Imani Fooladi; Sumitaka Yamanaka; Toru Furukawa; Masaharu Ishida; Daisuke Sato; Zhaodi Gu; Hiroki Nagase; Shinichi Egawa; Makoto Sunamura; Akira Horii
RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells.
Biochemical and biophysical research communications 2009;390(3):475-80.
2009: Jun Unno; Kennichi Satoh; Morihisa Hirota; Atsushi Kanno; Shin Hamada; Hiromichi Ito; Atsushi Masamune; Nobukazu Tsukamoto; Fuyuhiko Motoi; Shinichi Egawa; Michiaki Unno; Akira Horii; Tooru Shimosegawa
LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells.
International journal of oncology 2009;35(4):813-21.
2009: Shinichi Fukushige; Emiko Kondo; Akira Horii
Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells.
Biochemical and biophysical research communications 2009;379(4):1021-6.
2009: Yoshinori Sasaki; Tomoyuki Ohtani; Yumiko Ito; Masato Mizuashi; Satoshi Nakagawa; Toru Furukawa; Akira Horii; Setsuya Aiba
Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production.
International archives of allergy and immunology 2009;148(3):239-50.
2008: Zhaodi Gu; Hidetoshi Mitsui; Kenichi Inomata; Masako Honda; Chiaki Endo; Akira Sakurada; Masami Sato; Yoshinori Okada; Takashi Kondo; Akira Horii
The methylation status of FBXW7 beta-form correlates with histological subtype in human thymoma.
Biochemical and biophysical research communications 2008;377(2):685-8.
2008: Shinichi Fukushige; Emiko Kondo; Akira Horii
Methyl-CpG targeted transcriptional activation allows re-expression of tumor suppressor genes in human cancer cells.
Biochemical and biophysical research communications 2008;377(2):600-5.
2008: Masaharu Ishida; Makoto Sunamura; Toru Furukawa; Liviu P Lefter; Rina Morita; Masanori Akada; Shinichi Egawa; Michiaki Unno; Akira Horii
The PMAIP1 gene on chromosome 18 is a candidate tumor suppressor gene in human pancreatic cancer.
Digestive diseases and sciences 2008;53(9):2576-82.
2008: Zhaodi Gu; Kenichi Inomata; Hidetoshi Mitsui; Akira Horii
Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas.
Genes & genetic systems 2008;83(4):347-52.
2008: Masaharu Ishida; Shinichi Egawa; Kei Kawaguchi; Takeshi Aoki; Naoaki Sakata; Yukio Mikami; Fuyuhiko Motoi; Tadayoshi Abe; Shoji Fukuyama; Yu Katayose; Makoto Sunamura; Michiaki Unno; Takuya Moriya; Akira Horii; Toru Furukawa
Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2008;8(6):577-82.
2008: Sumitaka Yamanaka; Zhaodi Gu; Masami Sato; Rumi Fujisaki; Kenichi Inomata; Akira Sakurada; Akira Inoue; Toshihiro Nukiwa; Takashi Kondo; Akira Horii
siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma.
Pathobiology : journal of immunopathology, molecular and cellular biology 2008;75(1):2-8.
2007: Masaharu Ishida; Shinichi Egawa; Takeshi Aoki; Naoaki Sakata; Yukio Mikami; Fuyuhiko Motoi; Tadayoshi Abe; Shoji Fukuyama; Makoto Sunamura; Michiaki Unno; Takuya Moriya; Akira Horii; Toru Furukawa
Characteristic clinicopathological features of the types of intraductal papillary-mucinous neoplasms of the pancreas.
Pancreas 2007;35(4):348-52.
2007: Yuki Yoshino; Masaharu Ishida; Akira Horii
A new 10-min ligation method using a modified buffer system with a very low amount of T4 DNA ligase: the "Coffee Break Ligation" technique.
Biotechnology letters 2007;29(10):1557-60.
2007: Masaharu Ishida; Makoto Sunamura; Toru Furukawa; Masanori Akada; Hiroko Fujimura; Emiko Shibuya; Shinichi Egawa; Michiaki Unno; Akira Horii
Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis.
World journal of gastroenterology : WJG 2007;13(34):4593-7.
2007: Zhaodi Gu; Kenichi Inomata; Kota Ishizawa; Akira Horii
The FBXW7 beta-form is suppressed in human glioma cells.
Biochemical and biophysical research communications 2007;354(4):992-8.
2006: Shinichi Fukushige; Emiko Kondo; Zhaodi Gu; Hideyuki Suzuki; Akira Horii
RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.
Biochemical and biophysical research communications 2006;351(1):85-92.
2006: Kazumi Ogawa; Kiyoto Shiga; Shigeru Saijo; Takenori Ogawa; Noriko Kimura; Akira Horii
A novel G106D alteration of the SDHD gene in a pedigree with familial paraganglioma.
American journal of medical genetics. Part A 2006;140(22):2441-6.
2006: Toru Furukawa; Akira Horii
[Mechanistic insights for pancreatic carcinogenesis].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 1():27-31.
2006: Toru Furukawa; Makoto Sunamura; Akira Horii
Molecular mechanisms of pancreatic carcinogenesis.
Cancer science 2006;97(1):1-7.
2005: Kazumi Ogawa; Chunlan Sun; Akira Horii
Exploration of genetic alterations in human endometrial cancer and melanoma: distinct tumorigenic pathways that share a frequent abnormal PI3K/AKT cascade.
Oncology reports 2005;14(6):1481-5.
2005: Toru Furukawa; Günter Klöppel; N Volkan Adsay; Jorge Albores-Saavedra; Noriyoshi Fukushima; Akira Horii; Ralph Hruban; Yo Kato; David S Klimstra; Daniel S Longnecker; Jutta Lüttges; G Johan A Offerhaus; Michio Shimizu; Makoto Sunamura; Arief Suriawinata; Kyoichi Takaori; Suguru Yonezawa
Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study.
Virchows Archiv : an international journal of pathology 2005;447(5):794-9.
2005: Toru Furukawa; Rumi Fujisaki; Yoshitaro Yoshida; Naomi Kanai; Makoto Sunamura; Tadayoshi Abe; Kazunori Takeda; Seiki Matsuno; Akira Horii
Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005;18(8):1034-42.
2005: Chunlan Sun; Takashi Yamato; Emiko Kondo; Toru Furukawa; Hidetoshi Ikeda; Akira Horii
Infrequent mutation of APC, AXIN1, and GSK3B in human pituitary adenomas with abnormal accumulation of CTNNB1.
Journal of neuro-oncology 2005;73(2):131-4.
2005: Emiko Kondo; Zhaodi Gu; Akira Horii; Shinichi Fukushige
The thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genes.
Molecular and cellular biology 2005;25(11):4388-96.
2005: Takayuki Ikeda; Sho Hashimoto; Shinichi Fukushige; Hiroaki Ohmori; Akira Horii
Comparative genomic hybridization and mutation analyses of sporadic schwannomas.
Journal of neuro-oncology 2005;72(3):225-30.
2005: Tatsuo Hata; Toru Furukawa; Makoto Sunamura; Shinichi Egawa; Fuyuhiko Motoi; Noriyuki Ohmura; Tomotoshi Marumoto; Hideyuki Saya; Akira Horii
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
Cancer research 2005;65(7):2899-905.
2005: Kiyoshi Kume; Atsushi Masamune; Hiroya Mizutamari; Kenzo Kaneko; Kazuhiro Kikuta; Masahiro Satoh; Kennichi Satoh; Kenji Kimura; Noriaki Suzuki; Yutaka Nagasaki; Akira Horii; Tooru Shimosegawa
Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2005;5(4-5):354-60.
2005: Shanhai Xu; Toru Furukawa; Naomi Kanai; Makoto Sunamura; Akira Horii
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Journal of human genetics 2005;50(4):159-67.
2004: Toshimasa Yatsuoka; Toru Furukawa; Makoto Sunamura; Seiki Matsuno; Akira Horii
TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells.
Oncology reports 2004;12(6):1263-8.
2004: Mitsuho Imai; Tsutomu Nakamura; Tetsu Akiyama; Akira Horii
Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of beta-catenin.
Oncology reports 2004;12(5):1099-103.
2004: Sumitaka Yamanaka; Makoto Sunamura; Toru Furukawa; Libo Sun; Liviu P Lefter; Tadayoshi Abe; Toshimasa Yatsuoka; Hiroko Fujimura; Emiko Shibuya; Noriko Kotobuki; Mitsuo Oshimura; Akira Sakurada; Masami Sato; Takashi Kondo; Seiki Matsuno; Akira Horii
Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis.
Laboratory investigation; a journal of technical methods and pathology 2004;84(10):1339-51.
2004: Liviu P Lefter; Viorel Scripcaru; Makoto Sunamura; Toru Furukawa; Seiki Matsuno; Mitsuo Oshimura; Vasile Drug; Cristian Dragomir; Akira Horii
Screening for functional tumor suppressor activity in pancreatic cancer.
Romanian journal of gastroenterology 2004;13(3):195-201.
2004: Yoshinori Sasaki; Chunbo Niu; Rui Makino; Chieko Kudo; Chunlan Sun; Hiroshi Watanabe; Jun Matsunaga; Kazuhiro Takahashi; Hachiro Tagami; Setsuya Aiba; Akira Horii
BRAF point mutations in primary melanoma show different prevalences by subtype.
The Journal of investigative dermatology 2004;123(1):177-83.
2004: Liviu P Lefter; Makoto Sunamura; Toru Furukawa; Toshimasa Yastsuoka; Hisashi Abe; Hiroko Inoue; Tadayoshi Abe; Shinichi Egawa; Koh Miura; Rina Morita; Akira Horii; Seiki Matsuno
Functional analysis of chromosome 18 in pancreatic cancer: strong evidence for new tumour suppressor genes.
Asian journal of surgery / Asian Surgical Association 2004;27(2):85-92.
2004: Makoto Sunamura; Liviu P Lefter; Dan G Duda; Rina Morita; Hiroko Inoue; Tadaaki Yokoyama; Toshimasa Yatsuoka; Tadayoshi Abe; Shinichi Egawa; Toru Furukawa; Shinichi Fukushige; Mitsuo Oshimura; Akira Horii; Seiki Matsuno
The role of chromosome 18 abnormalities in the progression of pancreatic adenocarcinoma.
Pancreas 2004;28(3):311-6.
2004: Toru Furukawa; Akira Horii
Molecular pathology of pancreatic cancer: in quest of tumor suppressor genes.
Pancreas 2004;28(3):253-6.
2004: Tatsuo Hata; Takenori Ogawa; Tada-aki Yokoyama; Shinichi Fukushige; Akira Horii; Toru Furukawa
DSCP1, a novel TP53-inducible gene, is upregulated by strong genotoxic stresses and its overexpression inhibits tumor cell growth in vitro.
International journal of oncology 2004;24(3):513-20.
2003: Masakazu Amari; Takuya Moriya; Takanori Ishida; Yuko Harada; Koji Ohnuki; Motohiro Takeda; Hironobu Sasano; Akira Horii; Noriaki Ohuchi
Loss of heterozygosity analyses of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast.
Japanese journal of clinical oncology 2003;33(11):556-62.
2003: Liviu P Lefter; Makoto Sunamura; Toru Furukawa; Kazunori Takeda; Noriko Kotobuki; Mitsuo Oshimura; Seiki Matsuno; Akira Horii
Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):5044-52.
2003: Dan G Duda; Makoto Sunamura; Liviu P Lefter; Toru Furukawa; Tadaaki Yokoyama; Toshimasa Yatsuoka; Tadayoshi Abe; Hiroko Inoue; Fuyuhiko Motoi; Shinichi Egawa; Seiki Matsuno; Akira Horii
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells.
Oncogene 2003;22(44):6857-64.
2003: Takenori Ogawa; Kiyoto Shiga; Sho Hashimoto; Toshimitsu Kobayashi; Akira Horii; Toru Furukawa
APAF-1-ALT, a novel alternative splicing form of APAF-1, potentially causes impeded ability of undergoing DNA damage-induced apoptosis in the LNCaP human prostate cancer cell line.
Biochemical and biophysical research communications 2003;306(2):537-43.
2003: Emiko Kondo; Hideyuki Suzuki; Akira Horii; Shinichi Fukushige
A yeast two-hybrid assay provides a simple way to evaluate the vast majority of hMLH1 germ-line mutations.
Cancer research 2003;63(12):3302-8.
2003: Toru Furukawa; Makoto Sunamura; Fuyuhiko Motoi; Seiki Matsuno; Akira Horii
Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer.
The American journal of pathology 2003;162(6):1807-15.
2003: Akira Horii
[Genetic diagnosis of human pancreatic cancer].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2003;100(3):292-7.
2002: Makoto Sunamura; Masaru Oonuma; Fuyuhiko Motoi; Hisashi Abe; Yukoh Saitoh; Toru Hoshida; Shigeru Ottomo; Akira Horii; Seiki Matsuno
Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus.
Human cell 2002;15(3):138-50.
2002: Liviu P Lefter; Toru Furukawa; Makoto Sunamura; Dan G Duda; Kazunori Takeda; Noriko Kotobuki; Mitsuo Oshimura; Seiki Matsuno; Akira Horii
Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines.
Genes, chromosomes & cancer 2002;34(2):234-42.
2002: Dan G Duda; Makoto Sunamura; Lucian Lozonschi; T Yokoyama; Toshimasa Yatsuoka; Fuyuhiko Motoi; Akira Horii; K Tani; S Asano; Y Nakamura; Seiki Matsuno
Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis.
British journal of cancer 2002;86(3):490-6.
2001: Hiroko Inoue; Toru Furukawa; Makoto Sunamura; Kazunori Takeda; Seiki Matsuno; Akira Horii
Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis.
Genes, chromosomes & cancer 2001;31(3):295-9.
2001: K Sakurada; Toru Furukawa; Y Kato; T Kayama; S Huang; Akira Horii
RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.
Genes, chromosomes & cancer 2001;30(2):207-11.
2001: N Makino; T Yamato; Hiroko Inoue; Toru Furukawa; Tadayoshi Abe; Tada-aki Yokoyama; Toshimasa Yatsuoka; Shinichi Fukushige; S Orikasa; T Takahashi; Akira Horii
Isolation and characterization of the human gene homologous to the Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):547-53.
2001: EM Youssef; K Kaneko; Toshimasa Yatsuoka; Y Hayashi; M Hoshi; Akira Horii; Toru Furukawa
Human BAC contig covering the deleted region in pancreatic cancer at 12q21.
DNA sequence : the journal of DNA sequencing and mapping 2001;11(6):541-6.
2001: K Kaneko; Y Nagasaki; Toru Furukawa; Hiroya Mizutamari; A Sato; Atsushi Masamune; Tooru Shimosegawa; Akira Horii
Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis.
Journal of human genetics 2001;46(5):293-7.
2001: S Semba; S Y Han; H Ikeda; Akira Horii
Frequent nuclear accumulation of beta-catenin in pituitary adenoma.
Cancer 2001;91(1):42-8.
2001: Chunlan Sun; T Yamato; Toru Furukawa; Y Ohnishi; H Kijima; Akira Horii
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Oncology reports 2001;8(1):89-92.
2000: M Hoshi; HO Shiwaku; Y Hayashi; Y Kaneko; Akira Horii
Deletion mapping of 14q32 in human neuroblastoma defines an 1,100-kb region of common allelic loss.
Medical and pediatric oncology 2000;35(6):522-5.
2000: M Yuki; K Yoshinaga; H Yamakawa; K Sakurada; S Sato; A Yajima; Akira Horii
Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.
Oncology reports 2000;7(6):1339-42.
2000: E Kondo; Toru Furukawa; K Yoshinaga; H Kijima; S Semba; Toshimasa Yatsuoka; Tada-aki Yokoyama; Shinichi Fukushige; Akira Horii
Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability.
International journal of oncology 2000;17(3):535-41.
2000: Toshimasa Yatsuoka; Makoto Sunamura; Toru Furukawa; Shinichi Fukushige; Tada-aki Yokoyama; Hiroko Inoue; K Shibuya; Kazunori Takeda; Seiki Matsuno; Akira Horii
Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma.
The American journal of gastroenterology 2000;95(8):2080-5.
2000: T Mayama; Shinichi Fukushige; Ryuzaburo Shineha; T Nishihira; S Satomi; Akira Horii
Frequent loss of copy number on the long arm of chromosome 21 in human esophageal squamous cell carcinoma.
International journal of oncology 2000;17(2):245-52.
2000: Akira Horii
[Genetic alterations in human pancreatic cancer].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2000;97(7):888-94.
2000: M Hoshi; N Otagiri; HO Shiwaku; S Asakawa; N Shimizu; Y Kaneko; R Ohi; Y Hayashi; Akira Horii
Detailed deletion mapping of chromosome band 14q32 in human neuroblastoma defines a 1.1-Mb region of common allelic loss.
British journal of cancer 2000;82(11):1801-7.
2000: T Ikeda; K Yoshinaga; A Suzuki; A Sakurada; H Ohmori; Akira Horii
Anticorresponding mutations of the KRAS and PTEN genes in human endometrial cancer.
Oncology reports 2000;7(3):567-70.
2000: S Semba; H Ouyang; S Y Han; Y Kato; Akira Horii
Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.
International journal of oncology 2000;16(4):731-7.
2000: T Ikeda; K Yoshinaga; S Semba; E Kondo; H Ohmori; Akira Horii
Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.
Oncology reports 2000;7(2):323-6.
2000: A Saito; Toru Furukawa; Shinichi Fukushige; S Koyama; M Hoshi; Y Hayashi; Akira Horii
p24/ING1-ALT1 and p47/ING1-ALT2, distinct alternative transcripts of p33/ING1.
Journal of human genetics 2000;45(3):177-81.
1999: A Sakurada; H Hamada; Shinichi Fukushige; Tada-aki Yokoyama; K Yoshinaga; Toru Furukawa; S Sato; A Yajima; M Sato; S Fujimura; Akira Horii
Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer.
International journal of oncology 1999;15(6):1069-74.
1999: Masakazu Amari; A Suzuki; T Moriya; K Yoshinaga; Goro Amano; Hironobu Sasano; N Ohuchi; S Satomi; Akira Horii
LOH analyses of premalignant and malignant lesions of human breast: frequent LOH in 8p, 16q, and 17q in atypical ductal hyperplasia.
Oncology reports 1999;6(6):1277-80.
1999: H Takeshita; M Sato; HO Shiwaku; S Semba; A Sakurada; M Hoshi; Y Hayashi; Y Tagawa; H Ayabe; Akira Horii
Expression of the DMBT1 gene is frequently suppressed in human lung cancer.
Japanese journal of cancer research : Gann 1999;90(9):903-8.
1999: A Suzuki; X Shao; X Q Song; T Hanaoka; S Irie; M Kashiwada; GJ Samara; Lanny G Close; T Aoki; M Fujimori; Y Ishikawa; M Hatori; M Hosaka; A Sakurada; M Sato; N Ohuchi; S Satomi; Shinichi Fukushige; Akira Horii; T Sato
Identification of a 5-cM region of common allelic loss on 8p12-p21 in human breast cancer and genomic analysis of the hEXT1L/EXTR1/EXTL3 gene in this locus.
International journal of oncology 1999;15(3):443-51.
1999: Yuriko Mori; M Matsunaga; Tadayoshi Abe; Shinichi Fukushige; K Miura; Makoto Sunamura; K Shiiba; M Sato; T Nukiwa; Akira Horii
Chromosome band 16q24 is frequently deleted in human gastric cancer.
British journal of cancer 1999;80(3-4):556-62.
1999: Tadayoshi Abe; N Makino; Toru Furukawa; H Ouyang; M Kimura; Toshimasa Yatsuoka; Tada-aki Yokoyama; Hiroko Inoue; Shinichi Fukushige; M Hoshi; Y Hayashi; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer.
Genes, chromosomes & cancer 1999;25(1):60-4.
1999: Toshimasa Yatsuoka; Toru Furukawa; Tadayoshi Abe; Tada-aki Yokoyama; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
International journal of pancreatology : official journal of the International Association of Pancreatology 1999;25(2):97-102.
1999: S Han; S Semba; Tadayoshi Abe; N Makino; Toru Furukawa; Shinichi Fukushige; H Takahashi; A Sakurada; M Sato; K Shiiba; S Matsuno; Y Nimura; A Nakagawara; Akira Horii
Infrequent somatic mutations of the p73 gene in various human cancers.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1999;25(2):194-8.
1999: T Yamato; K Orikasa; Shinichi Fukushige; S Orikasa; Akira Horii
Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3-->p14.2 in renal cell carcinoma.
Cytogenetics and cell genetics 1999;87(3-4):291-5.
1999: Toru Furukawa; EM Youssef; Toshimasa Yatsuoka; Tada-aki Yokoyama; N Makino; Hiroko Inoue; Shinichi Fukushige; M Hoshi; Y Hayashi; Makoto Sunamura; Akira Horii
Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene.
Journal of human genetics 1999;44(6):397-401.
1998: M Matsuzaki; S Nagase; Tadayoshi Abe; K Miura; K Shiiba; Makoto Sunamura; Akira Horii
Detailed deletion mapping on chromosome 1p32-p36 in human colorectal cancer: identification of three distinct regions of common allelic loss.
International journal of oncology 1998;13(6):1229-33.
1998: K Yoshinaga; Hironobu Sasano; Toru Furukawa; H Yamakawa; M Yuki; S Sato; A Yajima; Akira Horii
The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
Japanese journal of cancer research : Gann 1998;89(10):985-90.
1998: Shinichi Fukushige; Toru Furukawa; K Satoh; Makoto Sunamura; M Kobari; M Koizumi; Akira Horii
Loss of chromosome 18q is an early event in pancreatic ductal tumorigenesis.
Cancer research 1998;58(19):4222-6.
1998: H Yamakawa; S Nagase; M Yuki; HO Shiwaku; Toru Furukawa; K Yoshinaga; E Soeda; M Hoshi; Y Hayashi; S Sato; A Yajima; Akira Horii
Identification of a 100-kb region of common allelic loss on chromosome bands 10q25-q26 in human endometrial cancer.
Genes, chromosomes & cancer 1998;23(1):74-7.
1998: K Orikasa; S Orikasa; Akira Horii
Identification of a 700-kb region of common allelic loss in chromosome bands 3p14.3-p21.1 in human renal cell carcinoma.
Cancer genetics and cytogenetics 1998;104(2):104-10.
1998: M Sato; Yuriko Mori; A Sakurada; S Fujimura; Akira Horii
The H-cadherin (CDH13) gene is inactivated in human lung cancer.
Human genetics 1998;103(1):96-101.
1998: M Kimura; Toru Furukawa; Tadayoshi Abe; Toshimasa Yatsuoka; EM Youssef; Tada-aki Yokoyama; H Ouyang; Y Ohnishi; Makoto Sunamura; M Kobari; Seiki Matsuno; Akira Horii
Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer.
Cancer research 1998;58(11):2456-60.
1998: M Sato; Yuriko Mori; A Sakurada; Shinichi Fukushige; Y Ishikawa; E Tsuchiya; Y Saito; T Nukiwa; S Fujimura; Akira Horii
Identification of a 910-kb region of common allelic loss in chromosome bands 16q24.1-q24.2 in human lung cancer.
Genes, chromosomes & cancer 1998;22(1):1-8.
1998: T Mayama; T Nishihira; S Satomi; Akira Horii
[Frequent loss of heterozygosity on the long arm of chromosome 21 in human esophageal, squamous cell carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy 1998;25 Suppl 3():459-63.
1998: H Ouyang; Toru Furukawa; T Abe; Y Kato; Akira Horii
The BAX gene, the promoter of apoptosis, is mutated in genetically unstable cancers of the colorectum, stomach, and endometrium.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(4):1071-4.
1998: T Furukawa; Toshimasa Yatsuoka; EM Youssef; T Abe; T Yokoyama; Shinichi Fukushige; E Soeda; M Hoshi; Y Hayashi; M Sunamura; M Kobari; Akira Horii
Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer.
Cytogenetics and cell genetics 1998;82(3-4):156-9.
1998: M Sato; Yuriko Mori; A Sakurada; S Fujimura; Akira Horii
A GT dinucleotide repeat polymorphism in intron 1 of the H-cadherin (CDH13) gene.
Journal of human genetics 1998;43(4):285-6.
1998: K Orikasa; Shinichi Fukushige; S Hoshi; S Orikasa; K Kondo; Y Miyoshi; Y Kubota; Akira Horii
Infrequent genetic alterations of the PTEN gene in Japanese patients with sporadic prostate cancer.
Journal of human genetics 1998;43(4):228-30.
1997: A Sakurada; A Suzuki; M Sato; H Yamakawa; K Orikasa; S Uyeno; T Ono; N Ohuchi; S Fujimura; Akira Horii
Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary.
Japanese journal of cancer research : Gann 1997;88(11):1025-8.
1997: HO Shiwaku; S Wakatsuki; Yuriko Mori; Shinichi Fukushige; Akira Horii
Alternative splicing of GTBP in normal human tissues.
DNA research : an international journal for rapid publication of reports on genes and genomes 1997;4(5):359-62.
1997: A Suzuki; Shinichi Fukushige; S Nagase; N Ohuchi; S Satomi; Akira Horii
Frequent gains on chromosome arms 1q and/or 8q in human endometrial cancer.
Human genetics 1997;100(5-6):629-36.
1997: T Mayama; T Mori; K Abe; H Sasano; T Nishihira; S Satomi; Akira Horii
Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1997;23(4):298-303.
1997: Shinichi Fukushige; F M Waldman; M Kimura; Tadayoshi Abe; Toru Furukawa; Makoto Sunamura; M Kobari; Akira Horii
Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma.
Genes, chromosomes & cancer 1997;19(3):161-9.
1997: H Ouyang; HO Shiwaku; H Hagiwara; K Miura; Tadayoshi Abe; Y Kato; H Ohtani; K Shiiba; Rhonda F Souza; Meltzer Stephen J.; Akira Horii
The insulin-like growth factor II receptor gene is mutated in genetically unstable cancers of the endometrium, stomach, and colorectum.
Cancer research 1997;57(10):1851-4.
1997: Yuriko Mori; HO Shiwaku; Shinichi Fukushige; S Wakatsuki; M Sato; T Nukiwa; Akira Horii
Alternative splicing of hMSH2 in normal human tissues.
Human genetics 1997;99(5):590-5.
1997: S Nagase; H Yamakawa; S Sato; A Yajima; Akira Horii
Identification of a 790-kilobase region of common allelic loss in chromosome 10q25-q26 in human endometrial cancer.
Cancer research 1997;57(9):1630-3.
1996: S Nagase; S Sato; F Tezuka; Y Wada; A Yajima; Akira Horii
Deletion mapping on chromosome 10q25-q26 in human endometrial cancer.
British journal of cancer 1996;74(12):1979-83.
1996: M Kimura; Tadayoshi Abe; Makoto Sunamura; Seiki Matsuno; Akira Horii
Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: identification of a I-cM region of common allelic loss.
Genes, chromosomes & cancer 1996;17(2):88-93.
1996: Tadayoshi Abe; H Ouyang; T Migita; Y Kato; M Kimura; K Shiiba; Makoto Sunamura; Seiki Matsuno; Akira Horii
The somatic mutation frequency of the transforming growth factor beta receptor type II gene varies widely among different cancers with microsatellite instability.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 1996;22(5):474-7.
1996: Shinichi Fukushige; Akira Horii
[Disruption of mismatch repair system in human cancers].
Nihon rinsho. Japanese journal of clinical medicine 1996;54(4):1002-7.
1996: Shinichi Fukushige; S Wakatsuki; S Nagase; Akira Horii
Frameshift mutation at codon 642 of the hMLH1 gene in human endometrial cancer.
Human mutation 1996;8(4):394-5.