Username

Password

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Sueharu Horinouchi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Living Beings

Genes & Molecular Sequences

Chemicals & Drugs

Procedures

Physiology

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Marushima Kazuya; Ohnishi Yasuo; Horinouchi Sueharu
CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.
Akanuma Genki; Hara Hirofumi; Ohnishi Yasuo; Horinouchi Sueharu
Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus.
Katsuyama Yohei; Kita Tomoko; Horinouchi Sueharu
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Sueharu Horinouchi (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Marushima Kazuya; Ohnishi Yasuo; Horinouchi Sueharu
CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.
Journal of bacteriology 2009;191(19):5930-40.
2009: Akanuma Genki; Hara Hirofumi; Ohnishi Yasuo; Horinouchi Sueharu
Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus.
Molecular microbiology 2009;73(5):898-912.
2009: Katsuyama Yohei; Kita Tomoko; Horinouchi Sueharu
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
FEBS letters 2009;583(17):2799-803.
2009: Iida Aya; Ohnishi Yasuo; Horinouchi Sueharu
Identification and characterization of target genes of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius.
Microbiology (Reading, England) 2009;155(Pt 9):3021-32.
2009: Tezuka Takeaki; Hara Hirofumi; Ohnishi Yasuo; Horinouchi Sueharu
Identification and gene disruption of small noncoding RNAs in Streptomyces griseus.
Journal of bacteriology 2009;191(15):4896-904.
2009: Nakano Chiaki; Ozawa Hiroki; Akanuma Genki; Funa Nobutaka; Horinouchi Sueharu
Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.
Journal of bacteriology 2009;191(15):4916-23.
2009: Miyanaga Akimasa; Horinouchi Sueharu
Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.
The Journal of antibiotics 2009;62(7):371-6.
2009: Hara Hirofumi; Ohnishi Yasuo; Horinouchi Sueharu
DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus.
Microbiology (Reading, England) 2009;155(Pt 7):2197-210.
2009: Awakawa Takayoshi; Yokota Kosuke; Funa Nobutaka; Doi Fuminao; Mori Naoki; Watanabe Hidenori; Horinouchi Sueharu
Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase.
Chemistry & biology 2009;16(6):613-23.
2009: Horinouchi Sueharu
Combinatorial biosynthesis of plant medicinal polyketides by microorganisms.
Current opinion in chemical biology 2009;13(2):197-204.
2009: Katsuyama Yohei; Kita Tomoko; Funa Nobutaka; Horinouchi Sueharu
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
The Journal of biological chemistry 2009;284(17):11160-70.
2008: Horinouchi Sueharu
Combinatorial biosynthesis of non-bacterial and unnatural flavonoids, stilbenoids and curcuminoids by microorganisms.
The Journal of antibiotics 2008;61(12):709-28.
2008: Nishino Tomonori G; Miyazaki Masaya; Hoshino Hideto; Miwa Yoshihiro; Horinouchi Sueharu; Yoshida Minoru
14-3-3 regulates the nuclear import of class IIa histone deacetylases.
Biochemical and biophysical research communications 2008;377(3):852-6.
2008: Suzuki Hirokazu; Marushima Kazuya; Ohnishi Yasuo; Horinouchi Sueharu
A novel pair of terminal protein and telomere-associated protein for replication of the linear chromosome of Streptomyces griseus IFO13350.
Bioscience, biotechnology, and biochemistry 2008;72(11):2973-80.
2008: Katsuyama Yohei; Matsuzawa Miku; Funa Nobutaka; Horinouchi Sueharu
Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway.
Microbiology (Reading, England) 2008;154(Pt 9):2620-8.
2008: Kamemura Kazuo; Ito Akihiro; Shimazu Tadahiro; Matsuyama Akihisa; Maeda Satoko; Yao Tso-Pang; Horinouchi Sueharu; Khochbin Saadi; Yoshida Minoru
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
Biochemical and biophysical research communications 2008;374(1):84-9.
2008: Iida Aya; Ohnishi Yasuo; Horinouchi Sueharu
An OmpA family protein, a target of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius, controls acetic acid fermentation.
Journal of bacteriology 2008;190(14):5009-19.
2008: Suzuki Shigeo; Nakanishi Eiyu; Furihata Keiko; Miyamoto Katsushiro; Tsujibo Hiroshi; Watanabe Takeshi; Ohnishi Yasuo; Horinouchi Sueharu; Nagasawa Hiromichi; Sakuda Shohei
Chitinase inhibitor allosamidin promotes chitinase production of Streptomyces generally.
International journal of biological macromolecules 2008;43(1):13-9.
2008: Ohnishi Yasuo; Ishikawa Jun; Hara Hirofumi; Suzuki Hirokazu; Ikenoya Miwa; Ikeda Haruo; Yamashita Atsushi; Hattori Masahira; Horinouchi Sueharu
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.
Journal of bacteriology 2008;190(11):4050-60.
2008: Funabashi Masanori; Funa Nobutaka; Horinouchi Sueharu
Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus.
The Journal of biological chemistry 2008;283(20):13983-91.
2008: Shirai Atsuko; Matsuyama Akihisa; Yashiroda Yoko; Hashimoto Atsushi; Kawamura Yumi; Arai Ritsuko; Komatsu Yasuhiko; Horinouchi Sueharu; Yoshida Minoru
Global analysis of gel mobility of proteins and its use in target identification.
The Journal of biological chemistry 2008;283(16):10745-52.
2008: Iida Aya; Ohnishi Yasuo; Horinouchi Sueharu
Control of acetic acid fermentation by quorum sensing via N-acylhomoserine lactones in Gluconacetobacter intermedius.
Journal of bacteriology 2008;190(7):2546-55.
2008: Hirano Setsu; Tanaka Katsuyuki; Ohnishi Yasuo; Horinouchi Sueharu
Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.
Microbiology (Reading, England) 2008;154(Pt 3):905-14.
2008: Miyanaga Akimasa; Funa Nobutaka; Awakawa Takayoshi; Horinouchi Sueharu
Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):871-6.
2007: Lo Chor-Wai; Kaida Daisuke; Nishimura Shinichi; Matsuyama Akihisa; Yashiroda Yoko; Taoka Hiroshi; Ishigami Ken; Watanabe Hidenori; Nakajima Hidenori; Tani Tokio; Horinouchi Sueharu; Yoshida Minoru
Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast.
Biochemical and biophysical research communications 2007;364(3):573-7.
2007: Katsuyama Yohei; Matsuzawa Miku; Funa Nobutaka; Horinouchi Sueharu
In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativa.
The Journal of biological chemistry 2007;282(52):37702-9.
2007: Shimazu Tadahiro; Horinouchi Sueharu; Yoshida Minoru
[Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2007;52(13 Suppl):1751-7.
2007: Katsuyama Yohei; Funa Nobutaka; Horinouchi Sueharu
Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli.
Biotechnology journal 2007;2(10):1286-93.
2007: Kaida Daisuke; Motoyoshi Hajime; Tashiro Etsu; Nojima Takayuki; Hagiwara Masatoshi; Ishigami Ken; Watanabe Hidenori; Kitahara Takeshi; Yoshida Tatsuhiko; Nakajima Hidenori; Tani Tokio; Horinouchi Sueharu; Yoshida Minoru
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Nature chemical biology 2007;3(9):576-83.
2007: Nishida Hiromi; Ohnishi Yasuo; Beppu Teruhiko; Horinouchi Sueharu
Evolution of gamma-butyrolactone synthases and receptors in Streptomyces.
Environmental microbiology 2007;9(8):1986-94.
2007: Suzuki Hirokazu; Ohnishi Yasuo; Horinouchi Sueharu
GriC and GriD constitute a carboxylic acid reductase involved in grixazone biosynthesis in Streptomyces griseus.
The Journal of antibiotics 2007;60(6):380-7.
2007: Katsuyama Yohei; Funa Nobutaka; Miyahisa Ikuo; Horinouchi Sueharu
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.
Chemistry & biology 2007;14(6):613-21.
2007: Tanaka Akiko; Takano Yuji; Ohnishi Yasuo; Horinouchi Sueharu
AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs.
Journal of molecular biology 2007;369(2):322-33.
2007: Hoshino Hideto; Nishino Tomonori George; Tashiro Satoshi; Miyazaki Masaya; Ohmiya Yoshihiro; Igarashi Kazuhiko; Horinouchi Sueharu; Yoshida Minoru
Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.
Journal of biochemistry 2007;141(5):719-27.
2007: Funa Nobutaka; Awakawa Takayoshi; Horinouchi Sueharu
Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa.
The Journal of biological chemistry 2007;282(19):14476-81.
2007: Higashi Tatsuichiro; Iwasaki Yuko; Ohnishi Yasuo; Horinouchi Sueharu
A-factor and phosphate depletion signals are transmitted to the grixazone biosynthesis genes via the pathway-specific transcriptional activator GriR.
Journal of bacteriology 2007;189(9):3515-24.
2007: Suzuki Hirokazu; Ohnishi Yasuo; Horinouchi Sueharu
Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.
Journal of bacteriology 2007;189(5):2155-9.
2007: Horinouchi Sueharu
Mining and polishing of the treasure trove in the bacterial genus streptomyces.
Bioscience, biotechnology, and biochemistry 2007;71(2):283-99.
2007: Yamada Minoru; Natsume Ryo; Nakamatsu Tsuyoshi; Horinouchi Sueharu; Kawasaki Hisashi; Senda Toshiya
Crystallization and preliminary crystallographic analysis of DtsR1, a carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 2):120-2.
2007: Kato Jun-ya; Funa Nobutaka; Watanabe Hidenori; Ohnishi Yasuo; Horinouchi Sueharu
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2378-83.
2007: Shimazu Tadahiro; Horinouchi Sueharu; Yoshida Minoru
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.
The Journal of biological chemistry 2007;282(7):4470-8.
2007: Katsuyama Yohei; Miyahisa Ikuo; Funa Nobutaka; Horinouchi Sueharu
One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells.
Applied microbiology and biotechnology 2007;73(5):1143-9.
2006: Suzuki Hirokazu; Ohnishi Yasuo; Furusho Yasuhide; Sakuda Shohei; Horinouchi Sueharu
Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
The Journal of biological chemistry 2006;281(48):36944-51.
2006: Hirano Setsu; Kato Jun-ya; Ohnishi Yasuo; Horinouchi Sueharu
Control of the Streptomyces Subtilisin inhibitor gene by AdpA in the A-factor regulatory cascade in Streptomyces griseus.
Journal of bacteriology 2006;188(17):6207-16.
2006: Suzuki Shigeo; Nakanishi Eiyu; Ohira Tsuyoshi; Kawachi Ryu; Ohnishi Yasuo; Horinouchi Sueharu; Nagasawa Hiromichi; Sakuda Shohei
Chitinase inhibitor allosamidin is a signal molecule for chitinase production in its producing Streptomyces II. Mechanism for regulation of chitinase production by allosamidin through a two-component regulatory system.
The Journal of antibiotics 2006;59(7):410-7.
2006: Matsuyama Akihisa; Arai Ritsuko; Yashiroda Yoko; Shirai Atsuko; Kamata Ayako; Sekido Shigeko; Kobayashi Yumiko; Hashimoto Atsushi; Hamamoto Makiko; Hiraoka Yasushi; Horinouchi Sueharu; Yoshida Minoru
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Nature biotechnology 2006;24(7):841-7.
2006: Miyahisa Ikuo; Funa Nobutaka; Ohnishi Yasuo; Martens Stefan; Moriguchi Takaya; Horinouchi Sueharu
Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.
Applied microbiology and biotechnology 2006;71(1):53-8.
2006: Kataoka M; Hashimoto K-I; Yoshida M; Nakamatsu T; Horinouchi S; Kawasaki H
Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction.
Letters in applied microbiology 2006;42(5):471-6.
2006: Funa Nobutaka; Ozawa Hiroki; Hirata Aiko; Horinouchi Sueharu
Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6356-61.
2006: Tomono Ayami; Mashiko Mari; Shimazu Tadahiro; Inoue Hirotaka; Nagasawa Hiromichi; Yoshida Minoru; Ohnishi Yasuo; Horinouchi Sueharu
Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168.
The Journal of antibiotics 2006;59(2):117-23.
2006: Lee Kun-Hyung; Nishimura Shinichi; Matsunaga Shigeki; Fusetani Nobuhiro; Ichijo Hidenori; Horinouchi Sueharu; Yoshida Minoru
Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide.
Bioscience, biotechnology, and biochemistry 2006;70(1):161-71.
2006: Nakano Shigeru; Fukaya Masahiro; Horinouchi Sueharu
Putative ABC transporter responsible for acetic acid resistance in Acetobacter aceti.
Applied and environmental microbiology 2006;72(1):497-505.
2006: Suzuki Hirokazu; Furusho Yasuhide; Higashi Tatsuichiro; Ohnishi Yasuo; Horinouchi Sueharu
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
The Journal of biological chemistry 2006;281(2):824-33.
2005: Funa Nobutaka; Funabashi Masanori; Ohnishi Yasuo; Horinouchi Sueharu
Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus.
Journal of bacteriology 2005;187(23):8149-55.
2005: Tomono Ayami; Tsai Yisan; Ohnishi Yasuo; Horinouchi Sueharu
Three chymotrypsin genes are members of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.
Journal of bacteriology 2005;187(18):6341-53.
2005: Miyahisa Ikuo; Kaneko Masafumi; Funa Nobutaka; Kawasaki Hisashi; Kojima Hiroyuki; Ohnishi Yasuo; Horinouchi Sueharu
Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster.
Applied microbiology and biotechnology 2005;68(4):498-504.
2005: Kato Jun-ya; Hirano Setsu; Ohnishi Yasuo; Horinouchi Sueharu
The Streptomyces subtilisin inhibitor (SSI) gene in Streptomyces coelicolor A3(2).
Bioscience, biotechnology, and biochemistry 2005;69(8):1624-9.
2005: Tomono Ayami; Tsai Yisan; Yamazaki Haruka; Ohnishi Yasuo; Horinouchi Sueharu
Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus.
Journal of bacteriology 2005;187(16):5595-604.
2005: Kato Jun-Ya; Ohnishi Yasuo; Horinouchi Sueharu
Autorepression of AdpA of the AraC/XylS family, a key transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus.
Journal of molecular biology 2005;350(1):12-26.
2005: Lee Kun-Hyung; Nishimura Shinichi; Matsunaga Shigeki; Fusetani Nobuhiro; Horinouchi Sueharu; Yoshida Minoru
Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products.
Cancer science 2005;96(6):357-64.
2005: Funa Nobutaka; Funabashi Masanori; Yoshimura Etsuro; Horinouchi Sueharu
A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides.
The Journal of biological chemistry 2005;280(15):14514-23.
2005: Ohnishi Yasuo; Yamazaki Haruka; Kato Jun-Ya; Tomono Ayami; Horinouchi Sueharu
AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus.
Bioscience, biotechnology, and biochemistry 2005;69(3):431-9.
2005: Yonekawa Tohru; Ohnishi Yasuo; Horinouchi Sueharu
A calmodulin-like protein in the bacterial genus Streptomyces.
FEMS microbiology letters 2005;244(2):315-21.
2005: Kato Jun-Ya; Chi Won-Jae; Ohnishi Yasuo; Hong Soon-Kwang; Horinouchi Sueharu
Transcriptional control by A-factor of two trypsin genes in Streptomyces griseus.
Journal of bacteriology 2005;187(1):286-95.
2004: Nakajima Masahiro; Imamura Hiromi; Shoun Hirofumi; Horinouchi Sueharu; Wakagi Takayoshi
Transglycosylation activity of Dictyoglomus thermophilum amylase A.
Bioscience, biotechnology, and biochemistry 2004;68(11):2369-73.
2004: Matsuyama Akihisa; Shirai Atsuko; Yashiroda Yoko; Kamata Ayako; Horinouchi Sueharu; Yoshida Minoru
pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.
Yeast (Chichester, England) 2004;21(15):1289-305.
2004: Motoyoshi Hajime; Horigome Masato; Ishigami Ken; Yoshida Tatsuhiko; Horinouchi Sueharu; Yoshida Minoru; Watanabe Hidenori; Kitahara Takeshi
Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
Bioscience, biotechnology, and biochemistry 2004;68(10):2178-82.
2004: Yamazaki Haruka; Tomono Ayami; Ohnishi Yasuo; Horinouchi Sueharu
DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus.
Molecular microbiology 2004;53(2):555-72.
2004: Kada Shigeki; Nanamiya Hideaki; Kawamura Fujio; Horinouchi Sueharu
Glr, a glutamate racemase, supplies D-glutamate to both peptidoglycan synthesis and poly-gamma-glutamate production in gamma-PGA-producing Bacillus subtilis.
FEMS microbiology letters 2004;236(1):13-20.
2004: Sawai Reiko; Suzuki Ayano; Takano Yuji; Lee Ping-Chin; Horinouchi Sueharu
Phosphorylation of AfsR by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).
Gene 2004;334():53-61.
2004: Nakano Shigeru; Fukaya Masahiro; Horinouchi Sueharu
Enhanced expression of aconitase raises acetic acid resistance in Acetobacter aceti.
FEMS microbiology letters 2004;235(2):315-22.
2004: Kato Jun-ya; Miyahisa Ikuo; Mashiko Mari; Ohnishi Yasuo; Horinouchi Sueharu
A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus.
Journal of bacteriology 2004;186(7):2206-11.
2004: Ohnishi Yasuo; Furusho Yasuhide; Higashi Tatsuichiro; Chun Hyo-Kon; Furihata Kazuo; Sakuda Shohei; Horinouchi Sueharu
Structures of grixazone A and B, A-factor-dependent yellow pigments produced under phosphate depletion by Streptomyces griseus.
The Journal of antibiotics 2004;57(3):218-23.
2004: Natsume Ryo; Ohnishi Yasuo; Senda Toshiya; Horinouchi Sueharu
Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2).
Journal of molecular biology 2004;336(2):409-19.
2003: Natsume Ryo; Takeshita Ryo; Sugiyama Masakazu; Ohnishi Yasuo; Senda Toshiya; Horinouchi Sueharu
Crystallization of CprB, an autoregulator-receptor protein from Streptomyces coelicolor A3(2).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2313-5.
2003: Yamazaki Haruka; Takano Yuji; Ohnishi Yasuo; Horinouchi Sueharu
amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.
Molecular microbiology 2003;50(4):1173-87.
2003: Horinouchi Sueharu
AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).
Journal of industrial microbiology & biotechnology 2003;30(8):462-7.
2003: Kaneko Masafumi; Hwang Eui Il; Ohnishi Yasuo; Horinouchi Sueharu
Heterologous production of flavanones in Escherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria.
Journal of industrial microbiology & biotechnology 2003;30(8):456-61.
2003: Hwang Eui Il; Kaneko Masafumi; Ohnishi Yasuo; Horinouchi Sueharu
Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster.
Applied and environmental microbiology 2003;69(5):2699-706.
2003: Chater Keith F; Horinouchi Sueharu
Signalling early developmental events in two highly diverged Streptomyces species.
Molecular microbiology 2003;48(1):9-15.
2003: Yamazaki Haruka; Ohnishi Yasuo; Horinouchi Sueharu
Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus.
Journal of bacteriology 2003;185(4):1273-83.
2003: Kaneko Masafumi; Ohnishi Yasuo; Horinouchi Sueharu
Cinnamate:coenzyme A ligase from the filamentous bacterium streptomyces coelicolor A3(2).
Journal of bacteriology 2003;185(1):20-7.
2002: Matsuyama Akihisa; Shimazu Tadahiro; Sumida Yuko; Saito Akiko; Yoshimatsu Yasuhiro; Seigneurin-Berny Daphné; Osada Hiroyuki; Komatsu Yasuhiko; Nishino Norikazu; Khochbin Saadi; Horinouchi Sueharu; Yoshida Minoru
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
The EMBO journal 2002;21(24):6820-31.
2002: Kato Jun-ya; Suzuki Ayano; Yamazaki Haruka; Ohnishi Yasuo; Horinouchi Sueharu
Control by A-factor of a metalloendopeptidase gene involved in aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 2002;184(21):6016-25.
2002: Funa Nobutaka; Ohnishi Yasuo; Ebizuka Yutaka; Horinouchi Sueharu
Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis.
The Biochemical journal 2002;367(Pt 3):781-9.
2002: Sakai Yasushi; Tsujita Tetsuya; Akiyama Tadakazu; Yoshida Tatsuhiko; Mizukami Tamio; Akinaga Shiro; Horinouchi Sueharu; Yoshida Minoru; Yoshida Tetsuo
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.
The Journal of antibiotics 2002;55(10):863-72.
2002: Ohnishi Yasuo; Seo Jeong-Woo; Horinouchi Sueharu
Deprogrammed sporulation in Streptomyces.
FEMS microbiology letters 2002;216(1):1-7.
2002: Horinouchi Sueharu
A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus.
Frontiers in bioscience : a journal and virtual library 2002;7():d2045-57.
2002: Furumai Ryohei; Matsuyama Akihisa; Kobashi Nobuyuki; Lee Kun-Hyung; Nishiyama Makoto; Nakajima Hidenori; Tanaka Akito; Komatsu Yasuhiko; Nishino Norikazu; Yoshida Minoru; Horinouchi Sueharu
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.
Cancer research 2002;62(17):4916-21.
2002: Umeyama T; Lee P-C; Horinouchi S
Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces.
Applied microbiology and biotechnology 2002;59(4-5):419-25.
2002: Okue Masayuki; Watanabe Hidenori; Kasahara Koji; Yoshida Minoru; Horinouchi Sueharu; Kitahara Takeshi
Short-step syntheses of all stereoisomers of preussin and their bioactivities.
Bioscience, biotechnology, and biochemistry 2002;66(5):1093-6.
2002: Lee Ping-Chin; Umeyama Takashi; Horinouchi Sueharu
afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2).
Molecular microbiology 2002;43(6):1413-30.
2002: Ueda Kenji; Oinuma Ken-Ichi; Ikeda Go; Hosono Kuniaki; Ohnishi Yasuo; Horinouchi Sueharu; Beppu Teruhiko
AmfS, an extracellular peptidic morphogen in Streptomyces griseus.
Journal of bacteriology 2002;184(5):1488-92.
2002: Funa Nobutaka; Ohnishi Yasuo; Ebizuka Yutaka; Horinouchi Sueharu
Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus.
The Journal of biological chemistry 2002;277(7):4628-35.
2002: Seo Jeong-Woo; Ohnishi Yasuo; Hirata Aiko; Horinouchi Sueharu
ATP-binding cassette transport system involved in regulation of morphological differentiation in response to glucose in Streptomyces griseus.
Journal of bacteriology 2002;184(1):91-103.
2001: Ki S W; Kasahara K; Kwon H J; Ishigami K; Kitahara T; Beppu T; Yoshida M; Horinouchi S
Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.
Bioscience, biotechnology, and biochemistry 2001;65(11):2528-34.
2001: Umeyama T; Horinouchi S
Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein.
Journal of bacteriology 2001;183(19):5506-12.
2001: Horinouchi S; Ohnishi Y; Kang D K
The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus.
Journal of industrial microbiology & biotechnology 2001;27(3):177-82.
2001: Yoshida M; Furumai R; Nishiyama M; Komatsu Y; Nishino N; Horinouchi S
Histone deacetylase as a new target for cancer chemotherapy.
Cancer chemotherapy and pharmacology 2001;48 Suppl 1():S20-6.
2001: Chun H K; Ohnishi Y; Misawa N; Shindo K; Hayashi M; Harayama S; Horinouchi S
Biotransformation of phenanthrene and 1-methoxynaphthalene with Streptomyces lividans cells expressing a marine bacterial phenanthrene dioxygenase gene cluster.
Bioscience, biotechnology, and biochemistry 2001;65(8):1774-81.
2001: Komatsu Y; Tomizaki K Y; Tsukamoto M; Kato T; Nishino N; Sato S; Yamori T; Tsuruo T; Furumai R; Yoshida M; Horinouchi S; Hayashi H
Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.
Cancer research 2001;61(11):4459-66.
2001: Aikawa J; Park Y N; Sugiyama M; Nishiyama M; Horinouchi S; Beppu T
Replacements of amino acid residues at subsites and their effects on the catalytic properties of Rhizomucor pusillus pepsin, an aspartic proteinase from Rhizomucor pusillus.
Journal of biochemistry 2001;129(5):791-4.
2001: Akakura S; Yoshida M; Yoneda Y; Horinouchi S
A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135).
The Journal of biological chemistry 2001;276(18):14649-57.
2001: Yonekawa T; Ohnishi Y; Horinouchi S
A calcium-binding protein with four EF-hand motifs in Streptomyces ambofaciens.
Bioscience, biotechnology, and biochemistry 2001;65(1):156-60.
2001: Lee H S; Ohnishi Y; Horinouchi S
A sigmaB-like factor responsible for carotenoid biosynthesis in Streptomyces griseus.
Journal of molecular microbiology and biotechnology 2001;3(1):95-101.
2001: Furumai R; Komatsu Y; Nishino N; Khochbin S; Yoshida M; Horinouchi S
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):87-92.
2000: Ki S W; Ishigami K; Kitahara T; Kasahara K; Yoshida M; Horinouchi S
Radicicol binds and inhibits mammalian ATP citrate lyase.
The Journal of biological chemistry 2000;275(50):39231-6.
2000: Umeyama T; Naruoka A; Horinouchi S
Genetic and biochemical characterization of a protein phosphatase with dual substrate specificity in Streptomyces coelicolor A3(2).
Gene 2000;258(1-2):55-62.
2000: Kim Y B; Ki S W; Yoshida M; Horinouchi S
Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells.
The Journal of antibiotics 2000;53(10):1191-200.
2000: Ohnishi Y; Nishiyama Y; Sato R; Kameyama S; Horinouchi S
An oligoribonuclease gene in Streptomyces griseus.
Journal of bacteriology 2000;182(16):4647-53.
2000: Yamazaki H; Ohnishi Y; Horinouchi S
An A-factor-dependent extracytoplasmic function sigma factor (sigma(AdsA)) that is essential for morphological development in Streptomyces griseus.
Journal of bacteriology 2000;182(16):4596-605.
2000: Kukimoto M; Nishiyama M; Tanokura M; Horinouchi S
Gene organization for nitric oxide reduction in Alcaligenes faecalis S-6.
Bioscience, biotechnology, and biochemistry 2000;64(4):852-7.
2000: Yoshida M; Horinouchi S
[Histone deacetylase inhibitors--new anticancer agents?]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1090-5.
1999: Takeuchi K; Yamazaki H; Shiraishi N; Ohnishi Y; Nishikawa Y; Horinouchi S
Characterization of an alg2 mutant of the zygomycete fungus Rhizomucor pusillus.
Glycobiology 1999;9(12):1287-93.
1999: Yoshida M; Horinouchi S; Toda T
[Control of gene expression in response to stress by a transcription factor Pap1]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2396-402.
1999: Ohnishi Y; Kameyama S; Onaka H; Horinouchi S
The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor.
Molecular microbiology 1999;34(1):102-11.
1999: Yamazaki H; Ohnishi Y; Takeuchi K; Mori N; Shiraishi N; Sakata Y; Suzuki H; Horinouchi S
Genetic transformation of a Rhizomucor pusillus mutant defective in asparagine-linked glycosylation: production of a milk-clotting enzyme in a less-glycosylated form.
Applied microbiology and biotechnology 1999;52(3):401-9.
1999: Umeyama T; Lee P C; Ueda K; Horinouchi S
An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus.
Microbiology (Reading, England) 1999;145 ( Pt 9)():2281-92.
1999: Yonekawa T; Ohnishi Y; Horinouchi S
Involvement of amfC in physiological and morphological development in Streptomyces coelicolor A3(2).
Microbiology (Reading, England) 1999;145 ( Pt 9)():2273-80.
1999: Ohnishi Y; Horinouchi S
[Regulation of secondary metabolism and morphological differentiation by a microbial hormone in streptomyces]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(11):1552-61.
1999: Funa N; Ohnishi Y; Fujii I; Shibuya M; Ebizuka Y; Horinouchi S
A new pathway for polyketide synthesis in microorganisms.
Nature 1999;400(6747):897-9.
1999: Kudo H; Natsume R; Nishiyama M; Horinouchi S
Analysis of stability and catalytic properties of two tryptophanases from a thermophile.
Protein engineering 1999;12(8):687-92.
1999: Kudo N; Matsumori N; Taoka H; Fujiwara D; Schreiner E P; Wolff B; Yoshida M; Horinouchi S
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9112-7.
1999: Yoshida M; Kudo N; Horinouchi S
[Leptomycin: a specific inhibitor of protein nuclear export]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(9):1379-88.
1999: Kang D K; Li X M; Ochi K; Horinouchi S
Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus.
Microbiology (Reading, England) 1999;145 ( Pt 5)():1161-72.
1999: Kudo N; Taoka H; Toda T; Yoshida M; Horinouchi S
A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1.
The Journal of biological chemistry 1999;274(21):15151-8.
1999: Kim Y B; Lee K H; Sugita K; Yoshida M; Horinouchi S
Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase.
Oncogene 1999;18(15):2461-70.
1999: Kudo N; Taoka H; Yoshida M; Horinouchi S
Identification of a novel nuclear export signal sensitive to oxidative stress in yeast AP-1-like transcription factor.
Annals of the New York Academy of Sciences 1999;886():204-7.
1999: Kim Y B; Yoshida M; Horinouchi S
Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase.
Annals of the New York Academy of Sciences 1999;886():200-3.
1999: Yoshida M; Horinouchi S
Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export.
Annals of the New York Academy of Sciences 1999;886():23-36.
1998: Sugiyama M; Onaka H; Nakagawa T; Horinouchi S
Site-directed mutagenesis of the A-factor receptor protein: Val-41 important for DNA-binding and Trp-119 important for ligand-binding.
Gene 1998;222(1):133-44.
1998: Ki S W; Kasahara K; Kwon H J; Eishima J; Takesako K; Cooper J A; Yoshida M; Horinouchi S
Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system.
The Journal of antibiotics 1998;51(10):936-44.
1998: Yamazaki H; Shiraishi N; Takeuchi K; Ohnishi Y; Horinouchi S
Characterization of alg2 encoding a mannosyltransferase in the zygomycete fungus Rhizomucor pusillus.
Gene 1998;221(2):179-84.
1998: Kim Y B; Honda A; Yoshida M; Horinouchi S
phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A.
FEBS letters 1998;436(2):193-6.
1998: Ueda K; Hsheh C W; Tosaki T; Shinkawa H; Beppu T; Horinouchi S
Characterization of an A-factor-responsive repressor for amfR essential for onset of aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 1998;180(19):5085-93.
1998: Saito K; Yamazaki H; Ohnishi Y; Fujimoto S; Takahashi E; Horinouchi S
Production of trehalose synthase from a basidiomycete, Grifola frondosa, in Escherichia coli.
Applied microbiology and biotechnology 1998;50(2):193-8.
1998: Kudo N; Wolff B; Sekimoto T; Schreiner E P; Yoneda Y; Yanagida M; Horinouchi S; Yoshida M
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
Experimental cell research 1998;242(2):540-7.
1998: Mizunashi W; Nishiyama M; Horinouchi S; Beppu T
Overexpression of high-molecular-mass nitrile hydratase from Rhodococcus rhodochrous J1 in recombinant Rhodococcus cells.
Applied microbiology and biotechnology 1998;49(5):568-72.
1998: Onaka H; Nakagawa T; Horinouchi S
Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis.
Molecular microbiology 1998;28(4):743-53.
1998: Murakami K; Takeuchi K; Beppu T; Horinouchi S
Structure of asparagine-linked oligosaccharides of an aspartic proteinase from the zygomycete fungus Rhizomucor pusillus.
Microbiology (Reading, England) 1998;144 ( Pt 5)():1369-74.
1998: Sasaki S; Karube I; Hirota N; Arikawa Y; Nishiyama M; Kukimoto M; Horinouchi S; Beppu T
Application of nitrite reductase from Alcaligenes faecalis S-6 for nitrite measurement.
Biosensors & bioelectronics 1998;13(1):1-5.
1997: Kwon H J; Yoshida M; Nagaoka R; Obinata T; Beppu T; Horinouchi S
Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression.
Oncogene 1997;15(21):2625-31.
1997: Kudo N; Khochbin S; Nishi K; Kitano K; Yanagida M; Yoshida M; Horinouchi S
Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.
The Journal of biological chemistry 1997;272(47):29742-51.
1997: Ando N; Matsumori N; Sakuda S; Beppu T; Horinouchi S
Involvement of afsA in A-factor biosynthesis as a key enzyme.
The Journal of antibiotics 1997;50(10):847-52.
1997: Ando N; Ueda K; Horinouchi S
A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and a high concentration of A-factor during early growth.
Microbiology (Reading, England) 1997;143 ( Pt 8)():2715-23.
1997: Onaka H; Horinouchi S
DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences.
Molecular microbiology 1997;24(5):991-1000.
1997: Ohnishi Y; Beppu T; Horinouchi S
Two genes encoding serine protease homologues in Serratia marcescens and characterization of their products in Escherichia coli.
Journal of biochemistry 1997;121(5):902-13.
1997: Yoshida M; Usui T; Tsujimura K; Inagaki M; Beppu T; Horinouchi S
Biochemical differences between staurosporine-induced apoptosis and premature mitosis.
Experimental cell research 1997;232(2):225-39.
1997: Usui T; Yoshida M; Kasahara K; Honda A; Beppu T; Horinouchi S
A novel HSP70 gene of Schizosaccharomyces pombe that confers K-252a resistance.
Gene 1997;189(1):43-7.
1997: Onaka H; Sugiyama M; Horinouchi S
A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability.
Journal of bacteriology 1997;179(8):2748-52.
1997: Kasahara K; Yoshida M; Eishima J; Takesako K; Beppu T; Horinouchi S
Identification of preussin as a selective inhibitor for cell growth of the fission yeast ts mutants defective in Cdc2-regulatory genes.
The Journal of antibiotics 1997;50(3):267-9.
1997: Kondo K; Horinouchi S
Characterization of an insertion sequence, IS12528, from Gluconobacter suboxydans.
Applied and environmental microbiology 1997;63(3):1139-42.
1997: Kondo K; Horinouchi S
Characterization of the genes encoding the three-component membrane-bound alcohol dehydrogenase from Gluconobacter suboxydans and their expression in Acetobacter pasteurianus.
Applied and environmental microbiology 1997;63(3):1131-8.
1997: Kondo K; Horinouchi S
A new insertion sequence IS1452 from Acetobacter pasteurianus.
Microbiology (Reading, England) 1997;143 ( Pt 2)():539-46.
1997: Park Y N; Aikawa J; Nishiyama M; Horinouchi S; Beppu T
Site-directed mutagenesis of conserved Trp39 in Rhizomucor pusillus pepsin: possible role of Trp39 in maintaining Tyr75 in the correct orientation for maximizing catalytic activity.
Journal of biochemistry 1997;121(1):118-21.
1996: Umeyama T; Tanabe Y; Aigle B D; Horinouchi S
Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans.
FEMS microbiology letters 1996;144(2-3):177-84.
1996: Ohnishi Y; Horinouchi S
Extracellular production of a Serratia marcescens serine protease in Escherichia coli.
Bioscience, biotechnology, and biochemistry 1996;60(10):1551-8.
1996: Park Y N; Aikawa J; Nishiyama M; Horinouchi S; Beppu T
Involvement of a residue at position 75 in the catalytic mechanism of a fungal aspartic proteinase, Rhizomucor pusillus pepsin. Replacement of tyrosine 75 on the flap by asparagine enhances catalytic efficiency.
Protein engineering 1996;9(10):869-75.
1996: Kukimoto M; Nishiyama M; Tanokura M; Murphy M E; Adman E T; Horinouchi S
Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6.
FEBS letters 1996;394(1):87-90.
1996: Nishiyama M; Kinoshita M; Kudo H; Horinouchi S; Tanokura M
Enhancement of the turnover number of thermostable malate dehydrogenase by deleting hydrogen bonds around the catalytic site.
Biochemical and biophysical research communications 1996;225(3):844-8.
1996: Wada M; Beppu T; Horinouchi S
Integrative transformation of the zygomycete Rhizomucor pusillus by homologous recombination.
Applied microbiology and biotechnology 1996;45(5):652-7.
1996: Kukimoto M; Nishiyama M; Tanokura M; Adman E T; Horinouchi S
Studies on protein-protein interaction between copper-containing nitrite reductase and pseudoazurin from Alcaligenes faecalis S-6.
The Journal of biological chemistry 1996;271(23):13680-3.
1996: Ueda K; Umeyama T; Beppu T; Horinouchi S
The aerial mycelium-defective phenotype of Streptomyces griseus resulting from A-factor deficiency is suppressed by a Ser/Thr kinase of S. coelicolor A3(2).
Gene 1996;169(1):91-5.
1995: Kudo N; Kimura M; Beppu T; Horinouchi S
Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 1995;177(22):6401-10.
1995: Onaka H; Ando N; Nihira T; Yamada Y; Beppu T; Horinouchi S
Cloning and characterization of the A-factor receptor gene from Streptomyces griseus.
Journal of bacteriology 1995;177(21):6083-92.
1995: Kondo K; Beppu T; Horinouchi S
Cloning, sequencing, and characterization of the gene encoding the smallest subunit of the three-component membrane-bound alcohol dehydrogenase from Acetobacter pasteurianus.
Journal of bacteriology 1995;177(17):5048-55.
1995: Murphy M E; Turley S; Kukimoto M; Nishiyama M; Horinouchi S; Sasaki H; Tanokura M; Adman E T
Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc.
Biochemistry 1995;34(38):12107-17.
1995: Usui T; Yoshida M; Honda A; Beppu T; Horinouchi S
A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe.
Gene 1995;161(1):93-6.
1995: Kwon H J; Yoshida M; Muroya K; Hattori S; Nishida E; Fukui Y; Beppu T; Horinouchi S
Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without a decrease in the ras-GTP complex.
Journal of biochemistry 1995;118(1):221-8.
1995: Ueda K; Kim K M; Beppu T; Horinouchi S
Overexpression of a gene cluster encoding a chalcone synthase-like protein confers redbrown pigment production in Streptomyces griseus.
The Journal of antibiotics 1995;48(7):638-46.
1995: Horinouchi S
[Signal transduction involved in antibiotic production and morphogenesis in Streptomyces]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1995;40(8):986-99.
1995: Yoshida M; Horinouchi S; Beppu T
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(5):423-30.
1995: Nishiyama M; Kukimoto M; Beppu T; Horinouchi S
An operon encoding aspartokinase and purine phosphoribosyltransferase in Thermus flavus.
Microbiology (Reading, England) 1995;141 ( Pt 5)():1211-9.
1995: Kimura K; Miyake S; Makuuchi M; Morita R; Usui T; Yoshida M; Horinouchi S; Fukui Y
Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses.
Bioscience, biotechnology, and biochemistry 1995;59(4):678-82.
1995: Nomura N; Matsubara N; Horinouchi S; Beppu T
Secretion by Saccharomyces cerevisiae of human apolipoprotein E as a fusion to serum albumin.
Bioscience, biotechnology, and biochemistry 1995;59(3):532-4.
1995: Nomura N; Yamada H; Matsubara N; Horinouchi S; Beppu T
High level secretion by Saccharomyces cerevisiae of human apolipoprotein E as a fusion to Rhizomucor rennin.
Bioscience, biotechnology, and biochemistry 1995;59(3):382-7.
1995: Nomura N; Yamada H; Matsubara N; Horinouchi S; Beppu T
Secretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to Mucor rennin.
Applied microbiology and biotechnology 1995;42(6):865-70.
1995: Kukimoto M; Nishiyama M; Ohnuki T; Turley S; Adman E T; Horinouchi S; Beppu T
Identification of interaction site of pseudoazurin with its redox partner, copper-containing nitrite reductase from Alcaligenes faecalis S-6.
Protein engineering 1995;8(2):153-8.
1995: Horinouchi S; Beppu T
Autoregulators.
Biotechnology (Reading, Mass.) 1995;28():103-19.
1995: Park Y N; Nishiyama M; Horinouchi S; Beppu T
Site-directed mutagenesis revealed role of subsite residues of Mucor pusillus pepsin in catalytic function.
Advances in experimental medicine and biology 1995;362():559-63.
1995: Beppu T; Park Y N; Aikawa J; Nishiyama M; Horinouchi S
Tyrosine 75 on the flap contributes to enhance catalytic efficiency of a fungal aspartic proteinase, Mucor pusillus pepsin.
Advances in experimental medicine and biology 1995;362():501-9.
1994: Ohnishi Y; Nishiyama M; Horinouchi S; Beppu T
Involvement of the COOH-terminal pro-sequence of Serratia marcescens serine protease in the folding of the mature enzyme.
The Journal of biological chemistry 1994;269(52):32800-6.
1994: Tonouchi N; Tsuchida T; Yoshinaga F; Horinouchi S; Beppu T
A host-vector system for a cellulose-producing Acetobacter strain.
Bioscience, biotechnology, and biochemistry 1994;58(10):1899-901.
1994: Hashimoto Y; Nishiyama M; Horinouchi S; Beppu T
Nitrile hydratase gene from Rhodococcus sp. N-774 requirement for its downstream region for efficient expression.
Bioscience, biotechnology, and biochemistry 1994;58(10):1859-65.
1994: Hoshikawa Y; Kwon H J; Yoshida M; Horinouchi S; Beppu T
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
Experimental cell research 1994;214(1):189-97.
1994: Hitomi J; Park J S; Nishiyama M; Horinouchi S; Beppu T
Substrate-dependent change in the pH-activity profile of alkaline endo-1,4-beta-glucanase from an alkaline Bacillus sp.
Journal of biochemistry 1994;116(3):554-9.
1994: Matsumoto A; Hong S K; Ishizuka H; Horinouchi S; Beppu T
Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.
Gene 1994;146(1):47-56.
1994: Shimada K; Ohnishi Y; Horinouchi S; Beppu T
Extracellular transport of pseudoazurin of Alcaligenes faecalis in Escherichia coli using the COOH-terminal domain of Serratia marcescens serine protease.
Journal of biochemistry 1994;116(2):327-34.
1994: Horinouchi S; Beppu T
A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus.
Molecular microbiology 1994;12(6):859-64.
1994: Kukimoto M; Nishiyama M; Murphy M E; Turley S; Adman E T; Horinouchi S; Beppu T
X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction.
Biochemistry 1994;33(17):5246-52.
1994: Murakami K; Aikawa J; Wada M; Horinouchi S; Beppu T
A Mucor pusillus mutant defective in asparagine-linked glycosylation.
Journal of bacteriology 1994;176(9):2635-9.
1994: Nishi K; Yoshida M; Fujiwara D; Nishikawa M; Horinouchi S; Beppu T
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
The Journal of biological chemistry 1994;269(9):6320-4.
1994: Miyake K; Onaka H; Horinouchi S; Beppu T
Organization and nucleotide sequence of the secE-nusG region of Streptomyces griseus.
Biochimica et biophysica acta 1994;1217(1):97-100.
1993: Park J S; Hitomi J; Horinouchi S; Beppu T
Identification of two amino acids contributing the high enzyme activity in the alkaline pH range of an alkaline endoglucanase from a Bacillus sp.
Protein engineering 1993;6(8):921-6.
1993: Murakami K; Aikawa J; Horinouchi S; Beppu T
Characterization of an aspartic proteinase of Mucor pusillus expressed in Aspergillus oryzae.
Molecular & general genetics : MGG 1993;241(3-4):312-8.
1993: Takemura H; Kondo K; Horinouchi S; Beppu T
Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus.
Journal of bacteriology 1993;175(21):6857-66.
1993: Shikata S; Shimada K; Ohnishi Y; Horinouchi S; Beppu T
Characterization of secretory intermediates of Serratia marcescens serine protease produced during its extracellular secretion from Escherichia coli cells.
Journal of biochemistry 1993;114(5):723-31.
1993: Kijima M; Yoshida M; Sugita K; Horinouchi S; Beppu T
Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.
The Journal of biological chemistry 1993;268(30):22429-35.
1993: Kobayashi M; Komeda H; Nagasawa T; Nishiyama M; Horinouchi S; Beppu T; Yamada H; Shimizu S
Amidase coupled with low-molecular-mass nitrile hydratase from Rhodococcus rhodochrous J1. Sequencing and expression of the gene and purification and characterization of the gene product.
European journal of biochemistry / FEBS 1993;217(1):327-36.
1993: Duran R; Nishiyama M; Horinouchi S; Beppu T
Characterization of nitrile hydratase genes cloned by DNA screening from Rhodococcus erythropolis.
Bioscience, biotechnology, and biochemistry 1993;57(8):1323-8.
1993: Hirahara T; Horinouchi S; Beppu T
Cloning, nucleotide sequence, and overexpression in Escherichia coli of the beta-tyrosinase gene from an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Applied microbiology and biotechnology 1993;39(3):341-6.
1993: Abe K; Yoshida M; Naoki H; Horinouchi S; Beppu T
Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure.
The Journal of antibiotics 1993;46(5):735-40.
1993: Abe K; Yoshida M; Horinouchi S; Beppu T
Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. I. Screening, taxonomy, purification and biological activities.
The Journal of antibiotics 1993;46(5):728-34.
1993: Vujaklija D; Horinouchi S; Beppu T
Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus.
Journal of bacteriology 1993;175(9):2652-61.
1993: Nishiyama M; Suzuki J; Kukimoto M; Ohnuki T; Horinouchi S; Beppu T
Cloning and characterization of a nitrite reductase gene from Alcaligenes faecalis and its expression in Escherichia coli.
Journal of general microbiology 1993;139(4):725-33.
1993: Ueda K; Miyake K; Horinouchi S; Beppu T
A gene cluster involved in aerial mycelium formation in Streptomyces griseus encodes proteins similar to the response regulators of two-component regulatory systems and membrane translocators.
Journal of bacteriology 1993;175(7):2006-16.
1993: Murata T; Horinouchi S; Beppu T
Production of poly(L-aspartyl-L-phenylalanine) in Escherichia coli.
Journal of biotechnology 1993;28(2-3):301-12.
1993: Ishizuka H; Horinouchi S; Beppu T
Putrescine oxidase of Micrococcus rubens: primary structure and Escherichia coli.
Journal of general microbiology 1993;139(3):425-32.
1993: Yonezawa M; Suzuki J; Nishiyama M; Horinouchi S; Beppu T
Role of the amino-terminal amino acid sequences determining the in vitro refolding process of prochymosin polypeptide.
Journal of biotechnology 1993;28(1):85-97.
1993: Park J S; Nakamura A; Horinouchi S; Beppu T
Identification of the cellulose-binding domain of a Bacillus subtilis endoglucanase distinct from its catalytic domain.
Bioscience, biotechnology, and biochemistry 1993;57(2):260-4.
1993: Hong S K; Matsumoto A; Horinouchi S; Beppu T
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.
Molecular & general genetics : MGG 1993;236(2-3):347-54.
1993: Nishi K; Yoshida M; Horinouchi S; Beppu T
Mating of the fission yeast occurs independently of pmd1+ gene product, a structural homologue of budding yeast STE6 and mammalian P-glycoproteins.
Archives of microbiology 1993;160(2):162-5.
1993: Horinouchi S; Beppu T
A-factor and streptomycin biosynthesis in Streptomyces griseus.
Antonie van Leeuwenhoek 1993;64(2):177-86.
1992: Kwon H J; Yoshida M; Fukui Y; Horinouchi S; Beppu T
Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.
Cancer research 1992;52(24):6926-30.
1992: Ishizuka H; Horinouchi S; Kieser H M; Hopwood D A; Beppu T
A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.
Journal of bacteriology 1992;174(23):7585-94.
1992: Hirahara T; Suzuki S; Horinouchi S; Beppu T
Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Applied and environmental microbiology 1992;58(8):2633-42.
1992: Horinouchi S; Beppu T
Regulation of secondary metabolism and cell differentiation in Streptomyces: A-factor as a microbial hormone and the AfsR protein as a component of a two-component regulatory system.
Gene 1992;115(1-2):167-72.
1992: Hashimoto Y; Nishiyama M; Yu F; Watanabe I; Horinouchi S; Beppu T
Development of a host-vector system in a Rhodococcus strain and its use for expression of the cloned nitrile hydratase gene cluster.
Journal of general microbiology 1992;138(5):1003-10.
1992: Shikata S; Shimada K; Kataoka H; Horinouchi S; Beppu T
Detection of large COOH-terminal domains processed from the precursor of Serratia marcescens serine protease in the outer membrane of Escherichia coli.
Journal of biochemistry 1992;111(5):627-32.
1992: Nishiyama M; Suzuki J; Ohnuki T; Chang H C; Horinouchi S; Turley S; Adman E T; Beppu T
Site-directed mutagenesis of pseudoazurin from Alcaligenes faecalis S-6; Pro80Ala mutant exhibits marked increase in reduction potential.
Protein engineering 1992;5(2):177-84.
1992: Kwon H J; Yoshida M; Abe K; Horinouchi S; Beppu T
Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts.
Bioscience, biotechnology, and biochemistry 1992;56(3):538-9.
1992: Nishi K; Yoshida M; Nishimura M; Nishikawa M; Nishiyama M; Horinouchi S; Beppu T
A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins.
Molecular microbiology 1992;6(6):761-9.
1991: Kobayashi M; Nishiyama M; Nagasawa T; Horinouchi S; Beppu T; Yamada H
Cloning, nucleotide sequence and expression in Escherichia coli of two cobalt-containing nitrile hydratase genes from Rhodococcus rhodochrous J1.
Biochimica et biophysica acta 1991;1129(1):23-33.
1991: Suzuki S; Hirahara T; Horinouchi S; Beppu T
Purification and properties of thermostable tryptophanase from an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Agricultural and biological chemistry 1991;55(12):3059-66.
1991: Takemura H; Horinouchi S; Beppu T
Novel insertion sequence IS1380 from Acetobacter pasteurianus is involved in loss of ethanol-oxidizing ability.
Journal of bacteriology 1991;173(22):7070-6.
1991: Beppu T; Horinouchi S
Molecular mechanisms of the A-factor-dependent control of secondary metabolism in Streptomyces.
Planta medica 1991;57(7):S44-7.
1991: Vujaklija D; Ueda K; Hong S K; Beppu T; Horinouchi S
Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus.
Molecular & general genetics : MGG 1991;229(1):119-28.
1991: Nishiyama M; Shimada K; Horinouchi S; Beppu T
Role of threonine 190 in modulating the catalytic function of malate dehydrogenase from a thermophile Thermus flavus.
The Journal of biological chemistry 1991;266(22):14294-9.
1991: Hiramatsu R; Horinouchi S; Uchida E; Hayakawa T; Beppu T
The secretion leader of Mucor pusillus rennin which possesses an artificial Lys-Arg sequence directs the secretion of mature human growth hormone by Saccharomyces cerevisiae.
Applied and environmental microbiology 1991;57(7):2052-6.
1991: Park J S; Horinouchi S; Beppu T
Characterization of the leader peptide of an endo-type cellulase produced by an alkalophilic Streptomyces strain.
Agricultural and biological chemistry 1991;55(7):1745-50.
1991: Horinouchi S; Ishizuka H; Beppu T
Cloning, nucleotide sequence, and transcriptional analysis of the NAD(P)-dependent cholesterol dehydrogenase gene from a Nocardia sp. and its hyperexpression in Streptomyces spp.
Applied and environmental microbiology 1991;57(5):1386-93.
1991: Nishiyama M; Horinouchi S; Beppu T
Characterization of an operon encoding succinyl-CoA synthetase and malate dehydrogenase from Thermus flavus AT-62 and its expression in Escherichia coli.
Molecular & general genetics : MGG 1991;226(1-2):1-9.
1991: Nishiyama M; Horinouchi S; Kobayashi M; Nagasawa T; Yamada H; Beppu T
Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23.
Journal of bacteriology 1991;173(8):2465-72.
1991: Hong S K; Kito M; Beppu T; Horinouchi S
Phosphorylation of the AfsR product, a global regulatory protein for secondary-metabolite formation in Streptomyces coelicolor A3(2).
Journal of bacteriology 1991;173(7):2311-8.
1991: Hiramatsu R; Horinouchi S; Beppu T
Isolation and characterization of human pro-urokinase and its mutants accumulated within the yeast secretory pathway.
Gene 1991;99(2):235-41.
1991: Hashimoto Y; Nishiyama M; Ikehata O; Horinouchi S; Beppu T
Cloning and characterization of an amidase gene from Rhodococcus species N-774 and its expression in Escherichia coli.
Biochimica et biophysica acta 1991;1088(2):225-33.
1991: Abe K; Yoshida M; Usui T; Horinouchi S; Beppu T
Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases.
Experimental cell research 1991;192(1):122-7.
1991: Nakamura A; Fukumori F; Horinouchi S; Masaki H; Kudo T; Uozumi T; Horikoshi K; Beppu T
Construction and characterization of the chimeric enzymes between the Bacillus subtilis cellulase and an alkalophilic Bacillus cellulase.
The Journal of biological chemistry 1991;266(3):1579-83.
1991: Aikawa J; Hiramatsu R; Nishiyama M; Horinouchi S; Beppu T
A yeast expression system and site-directed mutagenesis of a fungal aspartic proteinase, Mucor rennin.
Advances in experimental medicine and biology 1991;306():233-42.
1990: Suzuki J; Hamu A; Nishiyama M; Horinouchi S; Beppu T
Site-directed mutagenesis reveals functional contribution of Thr218, Lys220 and Asp304 in chymosin.
Protein engineering 1990;4(1):69-71.
1990: Horinouchi S; Beppu T
[Gene expression in Streptomyces]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(14):2567-83.
1990: Horinouchi S; Kito M; Nishiyama M; Furuya K; Hong S K; Miyake K; Beppu T
Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2).
Gene 1990;95(1):49-56.
1990: Aikawa J; Yamashita T; Nishiyama M; Horinouchi S; Beppu T
Effects of glycosylation on the secretion and enzyme activity of Mucor rennin, an aspartic proteinase of Mucor pusillus, produced by recombinant yeast.
The Journal of biological chemistry 1990;265(23):13955-9.
1990: Hiramatsu R; Yamashita T; Aikawa J; Horinouchi S; Beppu T
The prepro-peptide of Mucor rennin directs the secretion of human growth hormone by Saccharomyces cerevisiae.
Applied and environmental microbiology 1990;56(7):2125-32.
1990: Miyake K; Kuzuyama T; Horinouchi S; Beppu T
The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation.
Journal of bacteriology 1990;172(6):3003-8.
1990: Nakamura A; Koide Y; Kawamura F; Horinouchi S; Uozumi T; Beppu T
Construction of a Bacillus subtilis strain deficient in three proteases.
Agricultural and biological chemistry 1990;54(5):1307-9.
1990: Yoshida M; Nishikawa M; Nishi K; Abe K; Horinouchi S; Beppu T
Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells.
Experimental cell research 1990;187(1):150-6.
1990: Azuma M; Nishi K; Horinouchi S; Beppu T
Ribonucleases catalyze the synthesis of B-factor (3'-butylphosphoryl AMP), an inducer of rifamycin production in a Nocardia sp.
The Journal of antibiotics 1990;43(3):321-3.
1990: Horinouchi S; Beppu T
Autoregulatory factors of secondary metabolism and morphogenesis in actinomycetes.
Critical reviews in biotechnology 1990;10(3):191-204.
1989: Miyazaki H; Yanagida N; Horinouchi S; Beppu T
Characterization of the precursor of Serratia marcescens serine protease and COOH-terminal processing of the precursor during its excretion through the outer membrane of Escherichia coli.
Journal of bacteriology 1989;171(12):6566-72.
1989: Tamaki T; Horinouchi S; Fukaya M; Okumura H; Kawamura Y; Beppu T
Nucleotide sequence of the membrane-bound aldehyde dehydrogenase gene from Acetobacter polyoxogenes.
Journal of biochemistry 1989;106(4):541-4.
1989: Hiramatsu R; Aikawa J; Horinouchi S; Beppu T
Secretion by yeast of the zymogen form of Mucor rennin, an aspartic proteinase of Mucor pusillus, and its conversion to the mature form.
The Journal of biological chemistry 1989;264(28):16862-6.
1989: Miyake K; Horinouchi S; Yoshida M; Chiba N; Mori K; Nogawa N; Morikawa N; Beppu T
Detection and properties of A-factor-binding protein from Streptomyces griseus.
Journal of bacteriology 1989;171(8):4298-302.
1989: Ikehata O; Nishiyama M; Horinouchi S; Beppu T
Primary structure of nitrile hydratase deduced from the nucleotide sequence of a Rhodococcus species and its expression in Escherichia coli.
European journal of biochemistry / FEBS 1989;181(3):563-70.
1989: Suzuki J; Sasaki K; Sasao Y; Hamu A; Kawasaki H; Nishiyama M; Horinouchi S; Beppu T
Alteration of catalytic properties of chymosin by site-directed mutagenesis.
Protein engineering 1989;2(7):563-9.
1989: Horinouchi S; Suzuki H; Nishiyama M; Beppu T
Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
Journal of bacteriology 1989;171(2):1206-10.
1989: Nakata K; Horinouchi S; Beppu T
Cloning and characterization of the carbapenem biosynthetic genes from Streptomyces fulvoviridis.
FEMS microbiology letters 1989;48(1):51-5.
1989: Horinouchi S; Malpartida F; Hopwood D A; Beppu T
afsB stimulates transcription of the actinorhodin biosynthetic pathway in Streptomyces coelicolor A3(2) and Streptomyces lividans.
Molecular & general genetics : MGG 1989;215(2):355-7.
1988: Horinouchi S; Fukusumi S; Ohshima T; Beppu T
Cloning and expression in Escherichia coli of two additional amylase genes of a strictly anaerobic thermophile, Dictyoglomus thermophilum, and their nucleotide sequences with extremely low guanine-plus-cytosine contents.
European journal of biochemistry / FEBS 1988;176(2):243-53.
1988: Nakai R; Horinouchi S; Beppu T
Cloning and nucleotide sequence of a cellulase gene, casA, from an alkalophilic Streptomyces strain.
Gene 1988;65(2):229-38.
1988: Fukusumi S; Kamizono A; Horinouchi S; Beppu T
Cloning and nucleotide sequence of a heat-stable amylase gene from an anaerobic thermophile, Dictyoglomus thermophilum.
European journal of biochemistry / FEBS 1988;174(1):15-21.
1988: Kawaguchi T; Azuma M; Horinouchi S; Beppu T
Effect of B-factor and its analogues on rifamycin biosynthesis in Nocardia sp.
The Journal of antibiotics 1988;41(3):360-5.
1987: Horinouchi S; Nishiyama M; Nakamura A; Beppu T
Construction and characterization of multicopy expression-vectors in Streptomyces spp.
Molecular & general genetics : MGG 1987;210(3):468-75.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Sueharu Horinouchi

Research Profile (preview)

Concepts & Ideas

Living Beings

Genes & Molecular Sequences

Chemicals & Drugs

Procedures

Physiology

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Sueharu Horinouchi (preview)

All Publications