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Sueharu Horinouchi

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Hiroshi Otani; Akiyoshi Higo; Sueharu Horinouchi; Hideaki Nanamiya; Yasuo Ohnishi
An alternative sigma factor governs the principal sigma factor in Streptomyces griseus.
Hideki Yamamura; Akira Arisawa; Nobuyuki Fujita; Takeshi Harada; Sueharu Horinouchi; Yasutaka Hoshino; Natsuko Ichikawa; Haruo Ikeda; Jun Ishikawa; Youji Nakagawa; Yasuo Ohnishi; Misa Otoguro; Mitsuo Sekine; Ken-Ichiro Suzuki; Tomohiko Tamura; Masayuki Hayakawa
Complete genome sequence of the motile actinomycete Actinoplanes missouriensis 431(T) (= NBRC 102363(T)).
Chiaki Nakano; Sueharu Horinouchi; Takeaki Tezuka; Yasuo Ohnishi
Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus.

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2013: Hiroshi Otani; Akiyoshi Higo; Sueharu Horinouchi; Hideaki Nanamiya; Yasuo Ohnishi
An alternative sigma factor governs the principal sigma factor in Streptomyces griseus.
Molecular microbiology 2013;87(6):1223-36.
2012: Hideki Yamamura; Akira Arisawa; Nobuyuki Fujita; Takeshi Harada; Sueharu Horinouchi; Yasutaka Hoshino; Natsuko Ichikawa; Haruo Ikeda; Jun Ishikawa; Youji Nakagawa; Yasuo Ohnishi; Misa Otoguro; Mitsuo Sekine; Ken-Ichiro Suzuki; Tomohiko Tamura; Masayuki Hayakawa
Complete genome sequence of the motile actinomycete Actinoplanes missouriensis 431(T) (= NBRC 102363(T)).
Standards in genomic sciences 2012;7(2):294-303.
2012: Chiaki Nakano; Sueharu Horinouchi; Takeaki Tezuka; Yasuo Ohnishi
Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus.
The Journal of antibiotics 2012;65(11):551-8.
2012: Ryohei Nomoto; Masaru Tanokura; Takeaki Tezuka; Ken-ichi Miyazono; Sueharu Horinouchi; Yasuo Ohnishi
Purification, crystallization and preliminary X-ray analysis of SGR6054, a Streptomyces homologue of the mycobacterial integration host factor mIHF.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 9):1085-8.
2012: Ming Dong Yao; Ken-ichi Miyazono; Setsu Hirano; Sueharu Horinouchi; Koji Nagata; Yasuo Ohnishi; Jun Ohtsuka; Masaru Tanokura
Purification, crystallization and preliminary X-ray analysis of the DNA-binding domain of AdpA, the central transcription factor in the A-factor regulatory cascade in the filamentous bacterium Streptomyces griseus, in complex with a duplex DNA.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 8):946-9.
2012: Akiyoshi Higo; Sueharu Horinouchi; Hirofumi Hara; Yasuo Ohnishi
Genome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces, revealed the extent and complexity of the AdpA regulatory network.
DNA research : an international journal for rapid publication of reports on genes and genomes 2012;19(3):259-73.
2012: Chiaki Nakano; Yasuo Ohnishi; Nobutaka Funa; Sueharu Horinouchi
The O-methyltransferase SrsB catalyzes the decarboxylative methylation of alkylresorcylic acid during phenolic lipid biosynthesis by Streptomyces griseus.
Journal of bacteriology 2012;194(6):1544-51.
2012: Ken-ichi Miyazono; Sho Morita; Yasuo Ohnishi; Nobumitsu Tabei; Sueharu Horinouchi; Masaru Tanokura
Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus.
Journal of bacteriology 2012;194(3):607-16.
2012: Yukihide Sato; Sueharu Horinouchi; Yasuo Ohnishi
Characterization of a thermostable adenosine 5'-monophosphate deaminase gene in Streptomyces murinus.
The Journal of general and applied microbiology 2012;58(1):65-70.
2011: Takayuki Hayashi; Yuta Kitamura; Yasuo Ohnishi; Nobutaka Funa; Sueharu Horinouchi
Fatty acyl-AMP ligase involvement in the production of alkylresorcylic acid by a Myxococcus xanthus type III polyketide synthase.
Chembiochem : a European journal of chemical biology 2011;12(14):2166-76.
2011: Akiyoshi Higo; Sueharu Horinouchi; Yasuo Ohnishi
Strict regulation of morphological differentiation and secondary metabolism by a positive feedback loop between two global regulators AdpA and BldA in Streptomyces griseus.
Molecular microbiology 2011;81(6):1607-22.
2011: Chiaki Nakano; Sueharu Horinouchi; Yasuo Ohnishi
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
The Journal of biological chemistry 2011;286(32):27980-7.
2011: Ken-ichi Miyazono; Sueharu Horinouchi; Kazuya Marushima; Yasuo Ohnishi; Nobumitsu Tabei; Masaru Tanokura
Purification, crystallization and preliminary X-ray analysis of glucokinase from Streptomyces griseus in complex with glucose.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 8):914-6.
2011: Ryohei Furumai; Akihiro Ito; Kenji Ogawa; Satoko Maeda; Akiko Saito; Norikazu Nishino; Sueharu Horinouchi; Minoru Yoshida
Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment.
Cancer science 2011;102(5):1081-7.
2011: Kaoru Uchida; Moon-Sun Jang; Yasuo Ohnishi; Sueharu Horinouchi; Masayuki Hayakawa; Nobuyuki Fujita; Shin-Ichi Aizawa
Characterization of Actinoplanes missouriensis spore flagella.
Applied and environmental microbiology 2011;77(7):2559-62.
2011: Makoto Hasegawa; Tatsuhiro Miura; Kouji Kuzuya; Ayu Inoue; Se Won Ki; Sueharu Horinouchi; Tetsuo Yoshida; Tatsuki Kunoh; Koichi Koseki; Koshiki Mino; Ryuzo Sasaki; Minoru Yoshida; Tamio Mizukami
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product.
ACS chemical biology 2011;6(3):229-33.
2011: Yohei Katsuyama; Ken-ichi Miyazono; Masaru Tanokura; Yasuo Ohnishi; Sueharu Horinouchi
Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase.
The Journal of biological chemistry 2011;286(8):6659-68.
2011: Takayoshi Awakawa; Nobuyuki Fujita; Masayuki Hayakawa; Yasuo Ohnishi; Sueharu Horinouchi
Characterization of the biosynthesis gene cluster for alkyl-O-dihydrogeranyl-methoxyhydroquinones in Actinoplanes missouriensis.
Chembiochem : a European journal of chemical biology 2011;12(3):439-48.
2011: Genki Akanuma; Masayoshi Ueki; Morio Ishizuka; Yasuo Ohnishi; Sueharu Horinouchi
Control of aerial mycelium formation by the BldK oligopeptide ABC transporter in Streptomyces griseus.
FEMS microbiology letters 2011;315(1):54-62.
2011: Ken-ichi Miyazono; Jounghyun Um; Fabiana Lica Imai; Yohei Katsuyama; Yasuo Ohnishi; Sueharu Horinouchi; Masaru Tanokura
Crystal structure of curcuminoid synthase CUS from Oryza sativa.
Proteins 2011;79(2):669-73.
2011: Tomojiro Koide; Yasuo Ohnishi; Sueharu Horinouchi
Characterization of recombinant β-amylases from Oryza sativa.
Bioscience, biotechnology, and biochemistry 2011;75(4):793-6.
2011: Akio Noguchi; Sueharu Horinouchi; Yasuo Ohnishi
Substrate specificity of benzamide synthetase involved in 4-hydroxy-3-nitrosobenzamide biosynthesis.
The Journal of antibiotics 2011;64(1):93-6.
2010: Natsuko Ichikawa; Akio Oguchi; Haruo Ikeda; Jun Ishikawa; Shigeru Kitani; Yumi Watanabe; Sanae Nakamura; Yoko Katano; Emi Kishi; Machi Sasagawa; Akiho Ankai; Shigehiro Fukui; Yoshimi Hashimoto; Sachi Kamata; Misa Otoguro; Satoshi Tanikawa; Takuya Nihira; Sueharu Horinouchi; Yasuo Ohnishi; Masayuki Hayakawa; Tomohisa Kuzuyama; Akira Arisawa; Fumiki Nomoto; Hiromi Miura; Yoko Takahashi; Nobuyuki Fujita
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.
DNA research : an international journal for rapid publication of reports on genes and genomes 2010;17(6):393-406.
2010: Yohei Katsuyama; Yasuo Ohnishi; Sueharu Horinouchi
Production of dehydrogingerdione derivatives in Escherichia coli by exploiting a curcuminoid synthase from Oryza sativa and a β-oxidation pathway from Saccharomyces cerevisiae.
Chembiochem : a European journal of chemical biology 2010;11(14):2034-41.
2010: Akio Noguchi; Takeshi Kitamura; H Onaka; Sueharu Horinouchi; Yasuo Ohnishi
A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis.
Nature chemical biology 2010;6(9):641-3.
2010: Miku Matsuzawa; Yohei Katsuyama; Nobutaka Funa; Sueharu Horinouchi
Alkylresorcylic acid synthesis by type III polyketide synthases from rice Oryza sativa.
Phytochemistry 2010;71(10):1059-67.
2010: Yohei Katsuyama; Yutaka Hirose; Nobutaka Funa; Yasuo Ohnishi; Sueharu Horinouchi
Precursor-directed biosynthesis of curcumin analogs in Escherichia coli.
Bioscience, biotechnology, and biochemistry 2010;74(3):641-5.
2009: Kazuya Marushima; Yasuo Ohnishi; Sueharu Horinouchi
CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.
Journal of bacteriology 2009;191(19):5930-40.
2009: Yohei Katsuyama; Tomoko Kita; Sueharu Horinouchi
Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
FEBS letters 2009;583(17):2799-803.
2009: Takuya Miyakawa; Yasuo Ohnishi; Masaru Tanokura; Sueharu Horinouchi
[Structural and functional analysis of regulatory factors involved in antibiotic production in Streptomyces].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(12 Suppl):1696-701.
2009: Genki Akanuma; Hirofumi Hara; Yasuo Ohnishi; Sueharu Horinouchi
Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus.
Molecular microbiology 2009;73(5):898-912.
2009: Aya Iida; Yasuo Ohnishi; Sueharu Horinouchi
Identification and characterization of target genes of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius.
Microbiology (Reading, England) 2009;155(Pt 9):3021-32.
2009: Takeaki Tezuka; Hirofumi Hara; Yasuo Ohnishi; Sueharu Horinouchi
Identification and gene disruption of small noncoding RNAs in Streptomyces griseus.
Journal of bacteriology 2009;191(15):4896-904.
2009: Chiaki Nakano; Hiroki Ozawa; Genki Akanuma; Nobutaka Funa; Sueharu Horinouchi
Biosynthesis of aliphatic polyketides by type III polyketide synthase and methyltransferase in Bacillus subtilis.
Journal of bacteriology 2009;191(15):4916-23.
2009: Akimasa Miyanaga; Sueharu Horinouchi
Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases.
The Journal of antibiotics 2009;62(7):371-6.
2009: Hirofumi Hara; Yasuo Ohnishi; Sueharu Horinouchi
DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus.
Microbiology (Reading, England) 2009;155(Pt 7):2197-210.
2009: Takayoshi Awakawa; Kosuke Yokota; Nobutaka Funa; Fuminao Doi; Naoki Mori; Hidenori Watanabe; Sueharu Horinouchi
Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase.
Chemistry & biology 2009;16(6):613-23.
2009: Yohei Katsuyama; Tomoko Kita; Nobutaka Funa; Sueharu Horinouchi
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
The Journal of biological chemistry 2009;284(17):11160-70.
2009: Sueharu Horinouchi
Combinatorial biosynthesis of plant medicinal polyketides by microorganisms.
Current opinion in chemical biology 2009;13(2):197-204.
2008: Tomonori G Nishino; Masaya Miyazaki; Hideto Hoshino; Yoshihiro Miwa; Sueharu Horinouchi; Minoru Yoshida
14-3-3 regulates the nuclear import of class IIa histone deacetylases.
Biochemical and biophysical research communications 2008;377(3):852-6.
2008: Sueharu Horinouchi
Combinatorial biosynthesis of non-bacterial and unnatural flavonoids, stilbenoids and curcuminoids by microorganisms.
The Journal of antibiotics 2008;61(12):709-28.
2008: Hirokazu Suzuki; Kazuya Marushima; Yasuo Ohnishi; Sueharu Horinouchi
A novel pair of terminal protein and telomere-associated protein for replication of the linear chromosome of Streptomyces griseus IFO13350.
Bioscience, biotechnology, and biochemistry 2008;72(11):2973-80.
2008: Kazuo Kamemura; Akihiro Ito; Tadahiro Shimazu; Akihisa Matsuyama; Satoko Maeda; Tso-Pang Yao; Sueharu Horinouchi; Saadi Khochbin; Minoru Yoshida
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
Biochemical and biophysical research communications 2008;374(1):84-9.
2008: Yohei Katsuyama; Miku Matsuzawa; Nobutaka Funa; Sueharu Horinouchi
Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway.
Microbiology (Reading, England) 2008;154(Pt 9):2620-8.
2008: Aya Iida; Yasuo Ohnishi; Sueharu Horinouchi
An OmpA family protein, a target of the GinI/GinR quorum-sensing system in Gluconacetobacter intermedius, controls acetic acid fermentation.
Journal of bacteriology 2008;190(14):5009-19.
2008: Shigeo Suzuki; Eiyu Nakanishi; Keiko Furihata; Katsushiro Miyamoto; Hiroshi Tsujibo; Takeshi Watanabe; Yasuo Ohnishi; Sueharu Horinouchi; Hiromichi Nagasawa; Shohei Sakuda
Chitinase inhibitor allosamidin promotes chitinase production of Streptomyces generally.
International journal of biological macromolecules 2008;43(1):13-9.
2008: Yasuo Ohnishi; Jun Ishikawa; Hirofumi Hara; Hirokazu Suzuki; Miwa Ikenoya; Haruo Ikeda; Atsushi Yamashita; Masahira Hattori; Sueharu Horinouchi
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.
Journal of bacteriology 2008;190(11):4050-60.
2008: Masanori Funabashi; Nobutaka Funa; Sueharu Horinouchi
Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus.
The Journal of biological chemistry 2008;283(20):13983-91.
2008: Atsuko Shirai; Akihisa Matsuyama; Yoko Yashiroda; Atsushi Hashimoto; Yumi Kawamura; Ritsuko Arai; Yasuhiko Komatsu; Sueharu Horinouchi; Minoru Yoshida
Global analysis of gel mobility of proteins and its use in target identification.
The Journal of biological chemistry 2008;283(16):10745-52.
2008: Aya Iida; Yasuo Ohnishi; Sueharu Horinouchi
Control of acetic acid fermentation by quorum sensing via N-acylhomoserine lactones in Gluconacetobacter intermedius.
Journal of bacteriology 2008;190(7):2546-55.
2008: Setsu Hirano; Katsuyuki Tanaka; Yasuo Ohnishi; Sueharu Horinouchi
Conditionally positive effect of the TetR-family transcriptional regulator AtrA on streptomycin production by Streptomyces griseus.
Microbiology (Reading, England) 2008;154(Pt 3):905-14.
2008: Akimasa Miyanaga; Nobutaka Funa; Takayoshi Awakawa; Sueharu Horinouchi
Direct transfer of starter substrates from type I fatty acid synthase to type III polyketide synthases in phenolic lipid synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(3):871-6.
2007: Yohei Katsuyama; Miku Matsuzawa; Nobutaka Funa; Sueharu Horinouchi
In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativa.
The Journal of biological chemistry 2007;282(52):37702-9.
2007: Chor-Wai Lo; Daisuke Kaida; Shinichi Nishimura; Akihisa Matsuyama; Yoko Yashiroda; Hiroshi Taoka; Ken Ishigami; Hidenori Watanabe; Hidenori Nakajima; Tokio Tani; Sueharu Horinouchi; Minoru Yoshida
Inhibition of splicing and nuclear retention of pre-mRNA by spliceostatin A in fission yeast.
Biochemical and biophysical research communications 2007;364(3):573-7.
2007: Tadahiro Shimazu; Sueharu Horinouchi; Minoru Yoshida
[Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2007;52(13 Suppl):1751-7.
2007: Yohei Katsuyama; Nobutaka Funa; Sueharu Horinouchi
Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli.
Biotechnology journal 2007;2(10):1286-93.
2007: Daisuke Kaida; Hajime Motoyoshi; Etsu Tashiro; Takayuki Nojima; Masatoshi Hagiwara; Ken Ishigami; Hidenori Watanabe; Takeshi Kitahara; Tatsuhiko Yoshida; Hidenori Nakajima; Tokio Tani; Sueharu Horinouchi; Minoru Yoshida
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Nature chemical biology 2007;3(9):576-83.
2007: Hiromi Nishida; Yasuo Ohnishi; Teruhiko Beppu; Sueharu Horinouchi
Evolution of gamma-butyrolactone synthases and receptors in Streptomyces.
Environmental microbiology 2007;9(8):1986-94.
2007: Hirokazu Suzuki; Yasuo Ohnishi; Sueharu Horinouchi
GriC and GriD constitute a carboxylic acid reductase involved in grixazone biosynthesis in Streptomyces griseus.
The Journal of antibiotics 2007;60(6):380-7.
2007: Yohei Katsuyama; Nobutaka Funa; Ikuo Miyahisa; Sueharu Horinouchi
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.
Chemistry & biology 2007;14(6):613-21.
2007: Akiko Tanaka; Yuji Takano; Yasuo Ohnishi; Sueharu Horinouchi
AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs.
Journal of molecular biology 2007;369(2):322-33.
2007: Nobutaka Funa; Takayoshi Awakawa; Sueharu Horinouchi
Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa.
The Journal of biological chemistry 2007;282(19):14476-81.
2007: Hideto Hoshino; Tomonori George Nishino; Satoshi Tashiro; Masaya Miyazaki; Yoshihiro Ohmiya; Kazuhiko Igarashi; Sueharu Horinouchi; Minoru Yoshida
Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.
Journal of biochemistry 2007;141(5):719-27.
2007: Tatsuichiro Higashi; Yuko Iwasaki; Yasuo Ohnishi; Sueharu Horinouchi
A-factor and phosphate depletion signals are transmitted to the grixazone biosynthesis genes via the pathway-specific transcriptional activator GriR.
Journal of bacteriology 2007;189(9):3515-24.
2007: Hirokazu Suzuki; Yasuo Ohnishi; Sueharu Horinouchi
Arylamine N-acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus.
Journal of bacteriology 2007;189(5):2155-9.
2007: Tadahiro Shimazu; Sueharu Horinouchi; Minoru Yoshida
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.
The Journal of biological chemistry 2007;282(7):4470-8.
2007: Jun-ya Kato; Nobutaka Funa; Hidenori Watanabe; Yasuo Ohnishi; Sueharu Horinouchi
Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2378-83.
2007: Sueharu Horinouchi
Mining and polishing of the treasure trove in the bacterial genus streptomyces.
Bioscience, biotechnology, and biochemistry 2007;71(2):283-99.
2007: Minoru Yamada; Ryo Natsume; Tsuyoshi Nakamatsu; Sueharu Horinouchi; Hisashi Kawasaki; Toshiya Senda
Crystallization and preliminary crystallographic analysis of DtsR1, a carboxyltransferase subunit of acetyl-CoA carboxylase from Corynebacterium glutamicum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 2):120-2.
2007: Yohei Katsuyama; Ikuo Miyahisa; Nobutaka Funa; Sueharu Horinouchi
One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells.
Applied microbiology and biotechnology 2007;73(5):1143-9.
2006: Hirokazu Suzuki; Yasuo Ohnishi; Yasuhide Furusho; Shohei Sakuda; Sueharu Horinouchi
Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.
The Journal of biological chemistry 2006;281(48):36944-51.
2006: Setsu Hirano; Jun-ya Kato; Yasuo Ohnishi; Sueharu Horinouchi
Control of the Streptomyces Subtilisin inhibitor gene by AdpA in the A-factor regulatory cascade in Streptomyces griseus.
Journal of bacteriology 2006;188(17):6207-16.
2006: Shigeo Suzuki; Eiyu Nakanishi; Tsuyoshi Ohira; Ryu Kawachi; Yasuo Ohnishi; Sueharu Horinouchi; Hiromichi Nagasawa; Shohei Sakuda
Chitinase inhibitor allosamidin is a signal molecule for chitinase production in its producing Streptomyces II. Mechanism for regulation of chitinase production by allosamidin through a two-component regulatory system.
The Journal of antibiotics 2006;59(7):410-7.
2006: Akihisa Matsuyama; Ritsuko Arai; Yoko Yashiroda; Atsuko Shirai; Ayako Kamata; Shigeko Sekido; Yumiko Kobayashi; Atsushi Hashimoto; Makiko Hamamoto; Yasushi Hiraoka; Sueharu Horinouchi; Minoru Yoshida
ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Nature biotechnology 2006;24(7):841-7.
2006: Ikuo Miyahisa; Nobutaka Funa; Yasuo Ohnishi; Stefan Martens; Takaya Moriguchi; Sueharu Horinouchi
Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.
Applied microbiology and biotechnology 2006;71(1):53-8.
2006: M Kataoka; K-I Hashimoto; M Yoshida; Tsuyoshi Nakamatsu; Sueharu Horinouchi; Hisashi Kawasaki
Gene expression of Corynebacterium glutamicum in response to the conditions inducing glutamate overproduction.
Letters in applied microbiology 2006;42(5):471-6.
2006: Nobutaka Funa; Hiroki Ozawa; Aiko Hirata; Sueharu Horinouchi
Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(16):6356-61.
2006: Ayami Tomono; Mari Mashiko; Tadahiro Shimazu; Hirotaka Inoue; Hiromichi Nagasawa; Minoru Yoshida; Yasuo Ohnishi; Sueharu Horinouchi
Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168.
The Journal of antibiotics 2006;59(2):117-23.
2006: Hirokazu Suzuki; Yasuhide Furusho; Tatsuichiro Higashi; Yasuo Ohnishi; Sueharu Horinouchi
A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone.
The Journal of biological chemistry 2006;281(2):824-33.
2006: Kun-Hyung Lee; Shinichi Nishimura; Shigeki Matsunaga; Nobuhiro Fusetani; Hidenori Ichijo; Sueharu Horinouchi; Minoru Yoshida
Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide.
Bioscience, biotechnology, and biochemistry 2006;70(1):161-71.
2006: Shigeru Nakano; MASAHIRO FUKAYA; Sueharu Horinouchi
Putative ABC transporter responsible for acetic acid resistance in Acetobacter aceti.
Applied and environmental microbiology 2006;72(1):497-505.
2005: Nobutaka Funa; Masanori Funabashi; Yasuo Ohnishi; Sueharu Horinouchi
Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus.
Journal of bacteriology 2005;187(23):8149-55.
2005: Ayami Tomono; Yisan Tsai; Yasuo Ohnishi; Sueharu Horinouchi
Three chymotrypsin genes are members of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.
Journal of bacteriology 2005;187(18):6341-53.
2005: Ikuo Miyahisa; Masafumi Kaneko; Nobutaka Funa; Hisashi Kawasaki; Hiroyuki Kojima; Yasuo Ohnishi; Sueharu Horinouchi
Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster.
Applied microbiology and biotechnology 2005;68(4):498-504.
2005: Jun-ya Kato; Setsu Hirano; Yasuo Ohnishi; Sueharu Horinouchi
The Streptomyces subtilisin inhibitor (SSI) gene in Streptomyces coelicolor A3(2).
Bioscience, biotechnology, and biochemistry 2005;69(8):1624-9.
2005: Ayami Tomono; Yisan Tsai; Haruka Yamazaki; Yasuo Ohnishi; Sueharu Horinouchi
Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus.
Journal of bacteriology 2005;187(16):5595-604.
2005: Jun-Ya Kato; Yasuo Ohnishi; Sueharu Horinouchi
Autorepression of AdpA of the AraC/XylS family, a key transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus.
Journal of molecular biology 2005;350(1):12-26.
2005: Kun-Hyung Lee; Shinichi Nishimura; Shigeki Matsunaga; Nobuhiro Fusetani; Sueharu Horinouchi; Minoru Yoshida
Inhibition of protein synthesis and activation of stress-activated protein kinases by onnamide A and theopederin B, antitumor marine natural products.
Cancer science 2005;96(6):357-64.
2005: Nobutaka Funa; Masanori Funabashi; Etsuro Yoshimura; Sueharu Horinouchi
A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides.
The Journal of biological chemistry 2005;280(15):14514-23.
2005: Toshihiro Yonekawa; Yasuo Ohnishi; Sueharu Horinouchi
A calmodulin-like protein in the bacterial genus Streptomyces.
FEMS microbiology letters 2005;244(2):315-21.
2005: Yasuo Ohnishi; Haruka Yamazaki; Jun-Ya Kato; Ayami Tomono; Sueharu Horinouchi
AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus.
Bioscience, biotechnology, and biochemistry 2005;69(3):431-9.
2005: Jun-Ya Kato; Won-Jae Chi; Yasuo Ohnishi; Soon-Kwang Hong; Sueharu Horinouchi
Transcriptional control by A-factor of two trypsin genes in Streptomyces griseus.
Journal of bacteriology 2005;187(1):286-95.
2004: Masahiro Nakajima; Hiromi Imamura; Hirofumi Shoun; Sueharu Horinouchi; Takayoshi Wakagi
Transglycosylation activity of Dictyoglomus thermophilum amylase A.
Bioscience, biotechnology, and biochemistry 2004;68(11):2369-73.
2004: Akihisa Matsuyama; Atsuko Shirai; Yoko Yashiroda; Ayako Kamata; Sueharu Horinouchi; Minoru Yoshida
pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.
Yeast (Chichester, England) 2004;21(15):1289-305.
2004: Hajime Motoyoshi; Masato Horigome; Ken Ishigami; Tatsuhiko Yoshida; Sueharu Horinouchi; Minoru Yoshida; Hidenori Watanabe; Takeshi Kitahara
Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes.
Bioscience, biotechnology, and biochemistry 2004;68(10):2178-82.
2004: Haruka Yamazaki; Ayami Tomono; Yasuo Ohnishi; Sueharu Horinouchi
DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus.
Molecular microbiology 2004;53(2):555-72.
2004: Shigeki Kada; Hideaki Nanamiya; Fujio Kawamura; Sueharu Horinouchi
Glr, a glutamate racemase, supplies D-glutamate to both peptidoglycan synthesis and poly-gamma-glutamate production in gamma-PGA-producing Bacillus subtilis.
FEMS microbiology letters 2004;236(1):13-20.
2004: Shigeru Nakano; MASAHIRO FUKAYA; Sueharu Horinouchi
Enhanced expression of aconitase raises acetic acid resistance in Acetobacter aceti.
FEMS microbiology letters 2004;235(2):315-22.
2004: Reiko Sawai; Ayano Suzuki; Yuji Takano; Ping-Chin Lee; Sueharu Horinouchi
Phosphorylation of AfsR by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).
Gene 2004;334():53-61.
2004: Jun-ya Kato; Ikuo Miyahisa; Mari Mashiko; Yasuo Ohnishi; Sueharu Horinouchi
A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus.
Journal of bacteriology 2004;186(7):2206-11.
2004: Yasuo Ohnishi; Yasuhide Furusho; Tatsuichiro Higashi; Hyo-Kon Chun; Kazuo Furihata; Shohei Sakuda; Sueharu Horinouchi
Structures of grixazone A and B, A-factor-dependent yellow pigments produced under phosphate depletion by Streptomyces griseus.
The Journal of antibiotics 2004;57(3):218-23.
2004: Ryo Natsume; Yasuo Ohnishi; Toshiya Senda; Sueharu Horinouchi
Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2).
Journal of molecular biology 2004;336(2):409-19.
2003: Ryo Natsume; Ryo Takeshita; Masakazu Sugiyama; Yasuo Ohnishi; Toshiya Senda; Sueharu Horinouchi
Crystallization of CprB, an autoregulator-receptor protein from Streptomyces coelicolor A3(2).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2313-5.
2003: Haruka Yamazaki; Yuji Takano; Yasuo Ohnishi; Sueharu Horinouchi
amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus.
Molecular microbiology 2003;50(4):1173-87.
2003: Sueharu Horinouchi
AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2).
Journal of industrial microbiology & biotechnology 2003;30(8):462-7.
2003: Masafumi Kaneko; Eui Il Hwang; Yasuo Ohnishi; Sueharu Horinouchi
Heterologous production of flavanones in Escherichia coli: potential for combinatorial biosynthesis of flavonoids in bacteria.
Journal of industrial microbiology & biotechnology 2003;30(8):456-61.
2003: Eui Il Hwang; Masafumi Kaneko; Yasuo Ohnishi; Sueharu Horinouchi
Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster.
Applied and environmental microbiology 2003;69(5):2699-706.
2003: Keith F Chater; Sueharu Horinouchi
Signalling early developmental events in two highly diverged Streptomyces species.
Molecular microbiology 2003;48(1):9-15.
2003: Haruka Yamazaki; Yasuo Ohnishi; Sueharu Horinouchi
Transcriptional switch on of ssgA by A-factor, which is essential for spore septum formation in Streptomyces griseus.
Journal of bacteriology 2003;185(4):1273-83.
2003: Masafumi Kaneko; Yasuo Ohnishi; Sueharu Horinouchi
Cinnamate:coenzyme A ligase from the filamentous bacterium streptomyces coelicolor A3(2).
Journal of bacteriology 2003;185(1):20-7.
2002: Akihisa Matsuyama; Tadahiro Shimazu; Yuko Sumida; Akiko Saito; Yasuhiro Yoshimatsu; Daphné Seigneurin-Berny; Hiroyuki Osada; Yasuhiko Komatsu; Norikazu Nishino; Saadi Khochbin; Sueharu Horinouchi; Minoru Yoshida
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
The EMBO journal 2002;21(24):6820-31.
2002: Jun-ya Kato; Ayano Suzuki; Haruka Yamazaki; Yasuo Ohnishi; Sueharu Horinouchi
Control by A-factor of a metalloendopeptidase gene involved in aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 2002;184(21):6016-25.
2002: Nobutaka Funa; Yasuo Ohnishi; Yutaka Ebizuka; Sueharu Horinouchi
Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis.
The Biochemical journal 2002;367(Pt 3):781-9.
2002: Yasuo Ohnishi; Jeong-Woo Seo; Sueharu Horinouchi
Deprogrammed sporulation in Streptomyces.
FEMS microbiology letters 2002;216(1):1-7.
2002: Yasushi Sakai; Tetsuya Tsujita; Tadakazu Akiyama; Tetsuo Yoshida; Tamio Mizukami; Shiro Akinaga; Sueharu Horinouchi; Minoru Yoshida; Tetsuo Yoshida
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression.
The Journal of antibiotics 2002;55(10):863-72.
2002: Sueharu Horinouchi
A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus.
Frontiers in bioscience : a journal and virtual library 2002;7():d2045-57.
2002: Ryohei Furumai; Akihisa Matsuyama; Nobuyuki Kobashi; Kun-Hyung Lee; Makoto Nishiyama; Hidenori Nakajima; Akito Tanaka; Yasuhiko Komatsu; Norikazu Nishino; Minoru Yoshida; Sueharu Horinouchi
FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.
Cancer research 2002;62(17):4916-21.
2002: Takashige Umeyama; Ping-Chin Lee; Sueharu Horinouchi
Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces.
Applied microbiology and biotechnology 2002;59(4-5):419-25.
2002: Masayuki Okue; Hidenori Watanabe; Koji Kasahara; Minoru Yoshida; Sueharu Horinouchi; Takeshi Kitahara
Short-step syntheses of all stereoisomers of preussin and their bioactivities.
Bioscience, biotechnology, and biochemistry 2002;66(5):1093-6.
2002: Ping-Chin Lee; Takashige Umeyama; Sueharu Horinouchi
afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2).
Molecular microbiology 2002;43(6):1413-30.
2002: Kenji Ueda; Ken-Ichi Oinuma; Go Ikeda; Kuniaki Hosono; Yasuo Ohnishi; Sueharu Horinouchi; Teruhiko Beppu
AmfS, an extracellular peptidic morphogen in Streptomyces griseus.
Journal of bacteriology 2002;184(5):1488-92.
2002: Nobutaka Funa; Yasuo Ohnishi; Yutaka Ebizuka; Sueharu Horinouchi
Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus.
The Journal of biological chemistry 2002;277(7):4628-35.
2002: Jeong-Woo Seo; Yasuo Ohnishi; Aiko Hirata; Sueharu Horinouchi
ATP-binding cassette transport system involved in regulation of morphological differentiation in response to glucose in Streptomyces griseus.
Journal of bacteriology 2002;184(1):91-103.
2001: SW Ki; Koji Kasahara; H J Kwon; Ken Ishigami; Takeshi Kitahara; T Beppu; Masasuke Yoshida; Sueharu Horinouchi
Radicicol binding to Swo1/Hsp90 and inhibition of growth of specific temperature-sensitive cell cycle mutants of fission yeast.
Bioscience, biotechnology, and biochemistry 2001;65(11):2528-34.
2001: Takashige Umeyama; Sueharu Horinouchi
Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein.
Journal of bacteriology 2001;183(19):5506-12.
2001: Sueharu Horinouchi; Yasuo Ohnishi; D K Kang
The A-factor regulatory cascade and cAMP in the regulation of physiological and morphological development in Streptomyces griseus.
Journal of industrial microbiology & biotechnology 2001;27(3):177-82.
2001: Masasuke Yoshida; Ryohei Furumai; Makoto Nishiyama; Yasuhiko Komatsu; Norikazu Nishino; Sueharu Horinouchi
Histone deacetylase as a new target for cancer chemotherapy.
Cancer chemotherapy and pharmacology 2001;48 Suppl 1():S20-6.
2001: Hyo-Kon Chun; Yasuo Ohnishi; N Misawa; Kazutoshi Shindo; Makoto Hayashi; S Harayama; Sueharu Horinouchi
Biotransformation of phenanthrene and 1-methoxynaphthalene with Streptomyces lividans cells expressing a marine bacterial phenanthrene dioxygenase gene cluster.
Bioscience, biotechnology, and biochemistry 2001;65(8):1774-81.
2001: Yasuhiko Komatsu; K Y Tomizaki; M Tsukamoto; T Kato; Norikazu Nishino; S Sato; T Yamori; T Tsuruo; Ryohei Furumai; Masasuke Yoshida; Sueharu Horinouchi; H Hayashi
Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.
Cancer research 2001;61(11):4459-66.
2001: S Akakura; Masasuke Yoshida; Y Yoneda; Sueharu Horinouchi
A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135).
The Journal of biological chemistry 2001;276(18):14649-57.
2001: J Aikawa; Y N Park; M Sugiyama; M Nishiyama; Sueharu Horinouchi; T Beppu
Replacements of amino acid residues at subsites and their effects on the catalytic properties of Rhizomucor pusillus pepsin, an aspartic proteinase from Rhizomucor pusillus.
Journal of biochemistry 2001;129(5):791-4.
2001: Ryohei Furumai; Yasuhiko Komatsu; Norikazu Nishino; S Khochbin; Masasuke Yoshida; Sueharu Horinouchi
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):87-92.
2001: Toshihiro Yonekawa; Yasuo Ohnishi; Sueharu Horinouchi
A calcium-binding protein with four EF-hand motifs in Streptomyces ambofaciens.
Bioscience, biotechnology, and biochemistry 2001;65(1):156-60.
2001: H S Lee; Yasuo Ohnishi; Sueharu Horinouchi
A sigmaB-like factor responsible for carotenoid biosynthesis in Streptomyces griseus.
Journal of molecular microbiology and biotechnology 2001;3(1):95-101.
2000: SW Ki; Ken Ishigami; Takeshi Kitahara; Koji Kasahara; Masasuke Yoshida; Sueharu Horinouchi
Radicicol binds and inhibits mammalian ATP citrate lyase.
The Journal of biological chemistry 2000;275(50):39231-6.
2000: Takashige Umeyama; A Naruoka; Sueharu Horinouchi
Genetic and biochemical characterization of a protein phosphatase with dual substrate specificity in Streptomyces coelicolor A3(2).
Gene 2000;258(1-2):55-62.
2000: YB Kim; SW Ki; Masasuke Yoshida; Sueharu Horinouchi
Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells.
The Journal of antibiotics 2000;53(10):1191-200.
2000: Yasuo Ohnishi; Y Nishiyama; R Sato; S Kameyama; Sueharu Horinouchi
An oligoribonuclease gene in Streptomyces griseus.
Journal of bacteriology 2000;182(16):4647-53.
2000: Haruka Yamazaki; Yasuo Ohnishi; Sueharu Horinouchi
An A-factor-dependent extracytoplasmic function sigma factor (sigma(AdsA)) that is essential for morphological development in Streptomyces griseus.
Journal of bacteriology 2000;182(16):4596-605.
2000: M Kukimoto; Makoto Nishiyama; Masaru Tanokura; Sueharu Horinouchi
Gene organization for nitric oxide reduction in Alcaligenes faecalis S-6.
Bioscience, biotechnology, and biochemistry 2000;64(4):852-7.
2000: Masasuke Yoshida; Sueharu Horinouchi
[Histone deacetylase inhibitors--new anticancer agents?].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2000;45(6 Suppl):1090-5.
1999: K Takeuchi; H Yamazaki; N Shiraishi; Yasuo Ohnishi; Y Nishikawa; Sueharu Horinouchi
Characterization of an alg2 mutant of the zygomycete fungus Rhizomucor pusillus.
Glycobiology 1999;9(12):1287-93.
1999: Masasuke Yoshida; Sueharu Horinouchi; Tatsushi Toda
[Control of gene expression in response to stress by a transcription factor Pap1].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2396-402.
1999: Yasuo Ohnishi; S Kameyama; H Onaka; Sueharu Horinouchi
The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor.
Molecular microbiology 1999;34(1):102-11.
1999: H Yamazaki; Yasuo Ohnishi; K Takeuchi; N Mori; N Shiraishi; Y Sakata; H Suzuki; Sueharu Horinouchi
Genetic transformation of a Rhizomucor pusillus mutant defective in asparagine-linked glycosylation: production of a milk-clotting enzyme in a less-glycosylated form.
Applied microbiology and biotechnology 1999;52(3):401-9.
1999: Takashige Umeyama; Ping-Chin Lee; K Ueda; Sueharu Horinouchi
An AfsK/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus.
Microbiology (Reading, England) 1999;145 ( Pt 9)():2281-92.
1999: Toshihiro Yonekawa; Yasuo Ohnishi; Sueharu Horinouchi
Involvement of amfC in physiological and morphological development in Streptomyces coelicolor A3(2).
Microbiology (Reading, England) 1999;145 ( Pt 9)():2273-80.
1999: Yasuo Ohnishi; Sueharu Horinouchi
[Regulation of secondary metabolism and morphological differentiation by a microbial hormone in streptomyces].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(11):1552-61.
1999: Nobutaka Funa; Yasuo Ohnishi; Isao Fujii; Masaaki Shibuya; Yutaka Ebizuka; Sueharu Horinouchi
A new pathway for polyketide synthesis in microorganisms.
Nature 1999;400(6747):897-9.
1999: N Kudo; N Matsumori; H Taoka; D Fujiwara; Erwin P Schreiner; B Wolff; Masasuke Yoshida; Sueharu Horinouchi
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9112-7.
1999: H Kudo; Ryo Natsume; Makoto Nishiyama; Sueharu Horinouchi
Analysis of stability and catalytic properties of two tryptophanases from a thermophile.
Protein engineering 1999;12(8):687-92.
1999: Masasuke Yoshida; N Kudo; Sueharu Horinouchi
[Leptomycin: a specific inhibitor of protein nuclear export].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(9):1379-88.
1999: N Kudo; H Taoka; Tatsushi Toda; Masasuke Yoshida; Sueharu Horinouchi
A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor Pap1.
The Journal of biological chemistry 1999;274(21):15151-8.
1999: D K Kang; X M Li; K Ochi; Sueharu Horinouchi
Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus.
Microbiology (Reading, England) 1999;145 ( Pt 5)():1161-72.
1999: YB Kim; K H Lee; Kanji Sugita; Masasuke Yoshida; Sueharu Horinouchi
Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase.
Oncogene 1999;18(15):2461-70.
1999: N Kudo; H Taoka; Masasuke Yoshida; Sueharu Horinouchi
Identification of a novel nuclear export signal sensitive to oxidative stress in yeast AP-1-like transcription factor.
Annals of the New York Academy of Sciences 1999;886():204-7.
1999: YB Kim; Masasuke Yoshida; Sueharu Horinouchi
Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase.
Annals of the New York Academy of Sciences 1999;886():200-3.
1999: Masasuke Yoshida; Sueharu Horinouchi
Trichostatin and leptomycin. Inhibition of histone deacetylation and signal-dependent nuclear export.
Annals of the New York Academy of Sciences 1999;886():23-36.
1998: M Sugiyama; H Onaka; T Nakagawa; Sueharu Horinouchi
Site-directed mutagenesis of the A-factor receptor protein: Val-41 important for DNA-binding and Trp-119 important for ligand-binding.
Gene 1998;222(1):133-44.
1998: H Yamazaki; N Shiraishi; K Takeuchi; Yasuo Ohnishi; Sueharu Horinouchi
Characterization of alg2 encoding a mannosyltransferase in the zygomycete fungus Rhizomucor pusillus.
Gene 1998;221(2):179-84.
1998: YB Kim; A Honda; Masasuke Yoshida; Sueharu Horinouchi
phd1+, a histone deacetylase gene of Schizosaccharomyces pombe, is required for the meiotic cell cycle and resistance to trichostatin A.
FEBS letters 1998;436(2):193-6.
1998: SW Ki; Koji Kasahara; H J Kwon; J Eishima; K Takesako; J A Cooper; Masasuke Yoshida; Sueharu Horinouchi
Identification of radicicol as an inhibitor of in vivo Ras/Raf interaction with the yeast two-hybrid screening system.
The Journal of antibiotics 1998;51(10):936-44.
1998: Kenji Ueda; C W Hsheh; T Tosaki; H Shinkawa; Teruhiko Beppu; Sueharu Horinouchi
Characterization of an A-factor-responsive repressor for amfR essential for onset of aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 1998;180(19):5085-93.
1998: K Saito; H Yamazaki; Yasuo Ohnishi; S Fujimoto; E Takahashi; Sueharu Horinouchi
Production of trehalose synthase from a basidiomycete, Grifola frondosa, in Escherichia coli.
Applied microbiology and biotechnology 1998;50(2):193-8.
1998: N Kudo; B Wolff; T Sekimoto; Erwin P Schreiner; Y Yoneda; M Yanagida; Sueharu Horinouchi; Masasuke Yoshida
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1.
Experimental cell research 1998;242(2):540-7.
1998: W Mizunashi; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Overexpression of high-molecular-mass nitrile hydratase from Rhodococcus rhodochrous J1 in recombinant Rhodococcus cells.
Applied microbiology and biotechnology 1998;49(5):568-72.
1998: H Onaka; T Nakagawa; Sueharu Horinouchi
Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis.
Molecular microbiology 1998;28(4):743-53.
1998: K Murakami; K Takeuchi; T Beppu; Sueharu Horinouchi
Structure of asparagine-linked oligosaccharides of an aspartic proteinase from the zygomycete fungus Rhizomucor pusillus.
Microbiology (Reading, England) 1998;144 ( Pt 5)():1369-74.
1998: S Sasaki; Isao Karube; N Hirota; Yoshiko Arikawa; Makoto Nishiyama; M Kukimoto; Sueharu Horinouchi; T Beppu
Application of nitrite reductase from Alcaligenes faecalis S-6 for nitrite measurement.
Biosensors & bioelectronics 1998;13(1):1-5.
1997: N Kudo; S Khochbin; K Nishi; K Kitano; M Yanagida; Masasuke Yoshida; Sueharu Horinouchi
Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.
The Journal of biological chemistry 1997;272(47):29742-51.
1997: H J Kwon; Masasuke Yoshida; Reiko Nagaoka; Takashi Obinata; T Beppu; Sueharu Horinouchi
Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression.
Oncogene 1997;15(21):2625-31.
1997: N Ando; N Matsumori; Shohei Sakuda; Teruhiko Beppu; Sueharu Horinouchi
Involvement of afsA in A-factor biosynthesis as a key enzyme.
The Journal of antibiotics 1997;50(10):847-52.
1997: N Ando; K Ueda; Sueharu Horinouchi
A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and a high concentration of A-factor during early growth.
Microbiology (Reading, England) 1997;143 ( Pt 8)():2715-23.
1997: H Onaka; Sueharu Horinouchi
DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences.
Molecular microbiology 1997;24(5):991-1000.
1997: Y Ohnishi; T Beppu; Sueharu Horinouchi
Two genes encoding serine protease homologues in Serratia marcescens and characterization of their products in Escherichia coli.
Journal of biochemistry 1997;121(5):902-13.
1997: Masasuke Yoshida; T Usui; K Tsujimura; Masaki Inagaki; Teruhiko Beppu; Sueharu Horinouchi
Biochemical differences between staurosporine-induced apoptosis and premature mitosis.
Experimental cell research 1997;232(2):225-39.
1997: T Usui; M Yoshida; K Kasahara; A Honda; T Beppu; Sueharu Horinouchi
A novel HSP70 gene of Schizosaccharomyces pombe that confers K-252a resistance.
Gene 1997;189(1):43-7.
1997: H Onaka; M Sugiyama; Sueharu Horinouchi
A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability.
Journal of bacteriology 1997;179(8):2748-52.
1997: Koji Kasahara; Masasuke Yoshida; J Eishima; K Takesako; Teruhiko Beppu; Sueharu Horinouchi
Identification of preussin as a selective inhibitor for cell growth of the fission yeast ts mutants defective in Cdc2-regulatory genes.
The Journal of antibiotics 1997;50(3):267-9.
1997: Kimie Kondo; Sueharu Horinouchi
Characterization of an insertion sequence, IS12528, from Gluconobacter suboxydans.
Applied and environmental microbiology 1997;63(3):1139-42.
1997: Kimie Kondo; Sueharu Horinouchi
Characterization of the genes encoding the three-component membrane-bound alcohol dehydrogenase from Gluconobacter suboxydans and their expression in Acetobacter pasteurianus.
Applied and environmental microbiology 1997;63(3):1131-8.
1997: Kimie Kondo; Sueharu Horinouchi
A new insertion sequence IS1452 from Acetobacter pasteurianus.
Microbiology (Reading, England) 1997;143 ( Pt 2)():539-46.
1997: Y N Park; J Aikawa; M Nishiyama; Sueharu Horinouchi; T Beppu
Site-directed mutagenesis of conserved Trp39 in Rhizomucor pusillus pepsin: possible role of Trp39 in maintaining Tyr75 in the correct orientation for maximizing catalytic activity.
Journal of biochemistry 1997;121(1):118-21.
1996: T Umeyama; Y Tanabe; B D Aigle; Sueharu Horinouchi
Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans.
FEMS microbiology letters 1996;144(2-3):177-84.
1996: Y Ohnishi; Sueharu Horinouchi
Extracellular production of a Serratia marcescens serine protease in Escherichia coli.
Bioscience, biotechnology, and biochemistry 1996;60(10):1551-8.
1996: Y N Park; J Aikawa; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Involvement of a residue at position 75 in the catalytic mechanism of a fungal aspartic proteinase, Rhizomucor pusillus pepsin. Replacement of tyrosine 75 on the flap by asparagine enhances catalytic efficiency.
Protein engineering 1996;9(10):869-75.
1996: M Kukimoto; Makoto Nishiyama; Masaru Tanokura; M E Murphy; Elinor T Adman; Sueharu Horinouchi
Site-directed mutagenesis of azurin from Pseudomonas aeruginosa enhances the formation of an electron-transfer complex with a copper-containing nitrite reductase from Alcaligenes faecalis S-6.
FEBS letters 1996;394(1):87-90.
1996: Makoto Nishiyama; Makoto Kinoshita; H Kudo; Sueharu Horinouchi; M Tanokura
Enhancement of the turnover number of thermostable malate dehydrogenase by deleting hydrogen bonds around the catalytic site.
Biochemical and biophysical research communications 1996;225(3):844-8.
1996: M Kukimoto; Makoto Nishiyama; Masaru Tanokura; Elinor T Adman; Sueharu Horinouchi
Studies on protein-protein interaction between copper-containing nitrite reductase and pseudoazurin from Alcaligenes faecalis S-6.
The Journal of biological chemistry 1996;271(23):13680-3.
1996: M Wada; T Beppu; Sueharu Horinouchi
Integrative transformation of the zygomycete Rhizomucor pusillus by homologous recombination.
Applied microbiology and biotechnology 1996;45(5):652-7.
1996: K Ueda; T Umeyama; T Beppu; Sueharu Horinouchi
The aerial mycelium-defective phenotype of Streptomyces griseus resulting from A-factor deficiency is suppressed by a Ser/Thr kinase of S. coelicolor A3(2).
Gene 1996;169(1):91-5.
1995: N Kudo; M Kimura; T Beppu; Sueharu Horinouchi
Cloning and characterization of a gene involved in aerial mycelium formation in Streptomyces griseus.
Journal of bacteriology 1995;177(22):6401-10.
1995: H Onaka; N Ando; T Nihira; Y Yamada; T Beppu; Sueharu Horinouchi
Cloning and characterization of the A-factor receptor gene from Streptomyces griseus.
Journal of bacteriology 1995;177(21):6083-92.
1995: M E Murphy; S Turley; M Kukimoto; Makoto Nishiyama; Sueharu Horinouchi; H Sasaki; Masaru Tanokura; Elinor T Adman
Structure of Alcaligenes faecalis nitrite reductase and a copper site mutant, M150E, that contains zinc.
Biochemistry 1995;34(38):12107-17.
1995: Kimie Kondo; T Beppu; Sueharu Horinouchi
Cloning, sequencing, and characterization of the gene encoding the smallest subunit of the three-component membrane-bound alcohol dehydrogenase from Acetobacter pasteurianus.
Journal of bacteriology 1995;177(17):5048-55.
1995: T Usui; M Yoshida; A Honda; T Beppu; Sueharu Horinouchi
A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe.
Gene 1995;161(1):93-6.
1995: H J Kwon; M Yoshida; K Muroya; S Hattori; E Nishida; Yasuhisa Fukui; T Beppu; Sueharu Horinouchi
Morphology of ras-transformed cells becomes apparently normal again with tyrosine kinase inhibitors without a decrease in the ras-GTP complex.
Journal of biochemistry 1995;118(1):221-8.
1995: K Ueda; K M Kim; T Beppu; Sueharu Horinouchi
Overexpression of a gene cluster encoding a chalcone synthase-like protein confers redbrown pigment production in Streptomyces griseus.
The Journal of antibiotics 1995;48(7):638-46.
1995: Sueharu Horinouchi
[Signal transduction involved in antibiotic production and morphogenesis in Streptomyces].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1995;40(8):986-99.
1995: M Yoshida; Sueharu Horinouchi; T Beppu
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(5):423-30.
1995: Makoto Nishiyama; M Kukimoto; T Beppu; Sueharu Horinouchi
An operon encoding aspartokinase and purine phosphoribosyltransferase in Thermus flavus.
Microbiology (Reading, England) 1995;141 ( Pt 5)():1211-9.
1995: K Kimura; S Miyake; M Makuuchi; R Morita; Taichi Usui; M Yoshida; Sueharu Horinouchi; Yasuhisa Fukui
Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses.
Bioscience, biotechnology, and biochemistry 1995;59(4):678-82.
1995: N Nomura; N Matsubara; Sueharu Horinouchi; T Beppu
Secretion by Saccharomyces cerevisiae of human apolipoprotein E as a fusion to serum albumin.
Bioscience, biotechnology, and biochemistry 1995;59(3):532-4.
1995: N Nomura; H Yamada; N Matsubara; Sueharu Horinouchi; T Beppu
High level secretion by Saccharomyces cerevisiae of human apolipoprotein E as a fusion to Rhizomucor rennin.
Bioscience, biotechnology, and biochemistry 1995;59(3):382-7.
1995: N Nomura; H Yamada; N Matsubara; Sueharu Horinouchi; T Beppu
Secretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to Mucor rennin.
Applied microbiology and biotechnology 1995;42(6):865-70.
1995: M Kukimoto; Makoto Nishiyama; T Ohnuki; S Turley; Elinor T Adman; Sueharu Horinouchi; T Beppu
Identification of interaction site of pseudoazurin with its redox partner, copper-containing nitrite reductase from Alcaligenes faecalis S-6.
Protein engineering 1995;8(2):153-8.
1995: Sueharu Horinouchi; T Beppu
Autoregulators.
Biotechnology (Reading, Mass.) 1995;28():103-19.
1995: Y N Park; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Site-directed mutagenesis revealed role of subsite residues of Mucor pusillus pepsin in catalytic function.
Advances in experimental medicine and biology 1995;362():559-63.
1995: T Beppu; Y N Park; J Aikawa; Makoto Nishiyama; Sueharu Horinouchi
Tyrosine 75 on the flap contributes to enhance catalytic efficiency of a fungal aspartic proteinase, Mucor pusillus pepsin.
Advances in experimental medicine and biology 1995;362():501-9.
1994: Y Ohnishi; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Involvement of the COOH-terminal pro-sequence of Serratia marcescens serine protease in the folding of the mature enzyme.
The Journal of biological chemistry 1994;269(52):32800-6.
1994: Naoto Tonouchi; Takayasu Tsuchida; Fumihiro Yoshinaga; Sueharu Horinouchi; T Beppu
A host-vector system for a cellulose-producing Acetobacter strain.
Bioscience, biotechnology, and biochemistry 1994;58(10):1899-901.
1994: Yuichi Hashimoto; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Nitrile hydratase gene from Rhodococcus sp. N-774 requirement for its downstream region for efficient expression.
Bioscience, biotechnology, and biochemistry 1994;58(10):1859-65.
1994: Y Hoshikawa; H J Kwon; M Yoshida; Sueharu Horinouchi; T Beppu
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines.
Experimental cell research 1994;214(1):189-97.
1994: J Hitomi; J S Park; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Substrate-dependent change in the pH-activity profile of alkaline endo-1,4-beta-glucanase from an alkaline Bacillus sp.
Journal of biochemistry 1994;116(3):554-9.
1994: A Matsumoto; S K Hong; H Ishizuka; Sueharu Horinouchi; T Beppu
Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase.
Gene 1994;146(1):47-56.
1994: K Shimada; Y Ohnishi; Sueharu Horinouchi; T Beppu
Extracellular transport of pseudoazurin of Alcaligenes faecalis in Escherichia coli using the COOH-terminal domain of Serratia marcescens serine protease.
Journal of biochemistry 1994;116(2):327-34.
1994: Sueharu Horinouchi; T Beppu
A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus.
Molecular microbiology 1994;12(6):859-64.
1994: M Kukimoto; Makoto Nishiyama; M E Murphy; S Turley; Elinor T Adman; Sueharu Horinouchi; T Beppu
X-ray structure and site-directed mutagenesis of a nitrite reductase from Alcaligenes faecalis S-6: roles of two copper atoms in nitrite reduction.
Biochemistry 1994;33(17):5246-52.
1994: K Murakami; J Aikawa; M Wada; Sueharu Horinouchi; T Beppu
A Mucor pusillus mutant defective in asparagine-linked glycosylation.
Journal of bacteriology 1994;176(9):2635-9.
1994: K Nishi; M Yoshida; D Fujiwara; M Nishikawa; Sueharu Horinouchi; T Beppu
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.
The Journal of biological chemistry 1994;269(9):6320-4.
1994: K Miyake; H Onaka; Sueharu Horinouchi; T Beppu
Organization and nucleotide sequence of the secE-nusG region of Streptomyces griseus.
Biochimica et biophysica acta 1994;1217(1):97-100.
1993: J S Park; J Hitomi; Sueharu Horinouchi; T Beppu
Identification of two amino acids contributing the high enzyme activity in the alkaline pH range of an alkaline endoglucanase from a Bacillus sp.
Protein engineering 1993;6(8):921-6.
1993: K Murakami; J Aikawa; Sueharu Horinouchi; T Beppu
Characterization of an aspartic proteinase of Mucor pusillus expressed in Aspergillus oryzae.
Molecular & general genetics : MGG 1993;241(3-4):312-8.
1993: H Takemura; Kimie Kondo; Sueharu Horinouchi; T Beppu
Induction by ethanol of alcohol dehydrogenase activity in Acetobacter pasteurianus.
Journal of bacteriology 1993;175(21):6857-66.
1993: S Shikata; K Shimada; Y Ohnishi; Sueharu Horinouchi; T Beppu
Characterization of secretory intermediates of Serratia marcescens serine protease produced during its extracellular secretion from Escherichia coli cells.
Journal of biochemistry 1993;114(5):723-31.
1993: M Kijima; M Yoshida; K Sugita; Sueharu Horinouchi; T Beppu
Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.
The Journal of biological chemistry 1993;268(30):22429-35.
1993: Masayuki Kobayashi; Hidetsugu Komeda; T Nagasawa; Makoto Nishiyama; Sueharu Horinouchi; T Beppu; H Yamada; Sakayu Shimizu
Amidase coupled with low-molecular-mass nitrile hydratase from Rhodococcus rhodochrous J1. Sequencing and expression of the gene and purification and characterization of the gene product.
European journal of biochemistry / FEBS 1993;217(1):327-36.
1993: Robert Duran; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Characterization of nitrile hydratase genes cloned by DNA screening from Rhodococcus erythropolis.
Bioscience, biotechnology, and biochemistry 1993;57(8):1323-8.
1993: T Hirahara; Sueharu Horinouchi; T Beppu
Cloning, nucleotide sequence, and overexpression in Escherichia coli of the beta-tyrosinase gene from an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Applied microbiology and biotechnology 1993;39(3):341-6.
1993: K Abe; M Yoshida; H Naoki; Sueharu Horinouchi; T Beppu
Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure.
The Journal of antibiotics 1993;46(5):735-40.
1993: K Abe; M Yoshida; Sueharu Horinouchi; T Beppu
Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. I. Screening, taxonomy, purification and biological activities.
The Journal of antibiotics 1993;46(5):728-34.
1993: D Vujaklija; Sueharu Horinouchi; T Beppu
Detection of an A-factor-responsive protein that binds to the upstream activation sequence of strR, a regulatory gene for streptomycin biosynthesis in Streptomyces griseus.
Journal of bacteriology 1993;175(9):2652-61.
1993: Makoto Nishiyama; J Suzuki; M Kukimoto; T Ohnuki; Sueharu Horinouchi; T Beppu
Cloning and characterization of a nitrite reductase gene from Alcaligenes faecalis and its expression in Escherichia coli.
Journal of general microbiology 1993;139(4):725-33.
1993: K Ueda; K Miyake; Sueharu Horinouchi; T Beppu
A gene cluster involved in aerial mycelium formation in Streptomyces griseus encodes proteins similar to the response regulators of two-component regulatory systems and membrane translocators.
Journal of bacteriology 1993;175(7):2006-16.
1993: T Murata; Sueharu Horinouchi; T Beppu
Production of poly(L-aspartyl-L-phenylalanine) in Escherichia coli.
Journal of biotechnology 1993;28(2-3):301-12.
1993: H Ishizuka; Sueharu Horinouchi; T Beppu
Putrescine oxidase of Micrococcus rubens: primary structure and Escherichia coli.
Journal of general microbiology 1993;139(3):425-32.
1993: M Yonezawa; J Suzuki; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Role of the amino-terminal amino acid sequences determining the in vitro refolding process of prochymosin polypeptide.
Journal of biotechnology 1993;28(1):85-97.
1993: J S Park; Atsushi Nakamura; Sueharu Horinouchi; T Beppu
Identification of the cellulose-binding domain of a Bacillus subtilis endoglucanase distinct from its catalytic domain.
Bioscience, biotechnology, and biochemistry 1993;57(2):260-4.
1993: S K Hong; A Matsumoto; Sueharu Horinouchi; T Beppu
Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.
Molecular & general genetics : MGG 1993;236(2-3):347-54.
1993: K Nishi; M Yoshida; Sueharu Horinouchi; T Beppu
Mating of the fission yeast occurs independently of pmd1+ gene product, a structural homologue of budding yeast STE6 and mammalian P-glycoproteins.
Archives of microbiology 1993;160(2):162-5.
1993: Sueharu Horinouchi; T Beppu
A-factor and streptomycin biosynthesis in Streptomyces griseus.
Antonie van Leeuwenhoek 1993;64(2):177-86.
1992: H J Kwon; M Yoshida; Y Fukui; Sueharu Horinouchi; T Beppu
Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.
Cancer research 1992;52(24):6926-30.
1992: H Ishizuka; Sueharu Horinouchi; H M Kieser; D A Hopwood; T Beppu
A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp.
Journal of bacteriology 1992;174(23):7585-94.
1992: T Hirahara; S Suzuki; Sueharu Horinouchi; T Beppu
Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Applied and environmental microbiology 1992;58(8):2633-42.
1992: Sueharu Horinouchi; T Beppu
Regulation of secondary metabolism and cell differentiation in Streptomyces: A-factor as a microbial hormone and the AfsR protein as a component of a two-component regulatory system.
Gene 1992;115(1-2):167-72.
1992: Yuichi Hashimoto; Makoto Nishiyama; F Yu; I Watanabe; Sueharu Horinouchi; T Beppu
Development of a host-vector system in a Rhodococcus strain and its use for expression of the cloned nitrile hydratase gene cluster.
Journal of general microbiology 1992;138(5):1003-10.
1992: S Shikata; K Shimada; H Kataoka; Sueharu Horinouchi; T Beppu
Detection of large COOH-terminal domains processed from the precursor of Serratia marcescens serine protease in the outer membrane of Escherichia coli.
Journal of biochemistry 1992;111(5):627-32.
1992: Makoto Nishiyama; J Suzuki; T Ohnuki; H C Chang; Sueharu Horinouchi; S Turley; Elinor T Adman; T Beppu
Site-directed mutagenesis of pseudoazurin from Alcaligenes faecalis S-6; Pro80Ala mutant exhibits marked increase in reduction potential.
Protein engineering 1992;5(2):177-84.
1992: H J Kwon; M Yoshida; Keiko Abe; Sueharu Horinouchi; T Beppu
Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts.
Bioscience, biotechnology, and biochemistry 1992;56(3):538-9.
1992: K Nishi; M Yoshida; M Nishimura; M Nishikawa; M Nishiyama; Sueharu Horinouchi; T Beppu
A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins.
Molecular microbiology 1992;6(6):761-9.
1991: Masayuki Kobayashi; Makoto Nishiyama; T Nagasawa; Sueharu Horinouchi; T Beppu; H Yamada
Cloning, nucleotide sequence and expression in Escherichia coli of two cobalt-containing nitrile hydratase genes from Rhodococcus rhodochrous J1.
Biochimica et biophysica acta 1991;1129(1):23-33.
1991: S Suzuki; T Hirahara; Sueharu Horinouchi; T Beppu
Purification and properties of thermostable tryptophanase from an obligately symbiotic thermophile, Symbiobacterium thermophilum.
Agricultural and biological chemistry 1991;55(12):3059-66.
1991: H Takemura; Sueharu Horinouchi; T Beppu
Novel insertion sequence IS1380 from Acetobacter pasteurianus is involved in loss of ethanol-oxidizing ability.
Journal of bacteriology 1991;173(22):7070-6.
1991: T Beppu; Sueharu Horinouchi
Molecular mechanisms of the A-factor-dependent control of secondary metabolism in Streptomyces.
Planta medica 1991;57(7):S44-7.
1991: D Vujaklija; K Ueda; S K Hong; T Beppu; Sueharu Horinouchi
Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus.
Molecular & general genetics : MGG 1991;229(1):119-28.
1991: Makoto Nishiyama; K Shimada; Sueharu Horinouchi; T Beppu
Role of threonine 190 in modulating the catalytic function of malate dehydrogenase from a thermophile Thermus flavus.
The Journal of biological chemistry 1991;266(22):14294-9.
1991: R Hiramatsu; Sueharu Horinouchi; E Uchida; T Hayakawa; T Beppu
The secretion leader of Mucor pusillus rennin which possesses an artificial Lys-Arg sequence directs the secretion of mature human growth hormone by Saccharomyces cerevisiae.
Applied and environmental microbiology 1991;57(7):2052-6.
1991: J S Park; Sueharu Horinouchi; T Beppu
Characterization of the leader peptide of an endo-type cellulase produced by an alkalophilic Streptomyces strain.
Agricultural and biological chemistry 1991;55(7):1745-50.
1991: Sueharu Horinouchi; H Ishizuka; T Beppu
Cloning, nucleotide sequence, and transcriptional analysis of the NAD(P)-dependent cholesterol dehydrogenase gene from a Nocardia sp. and its hyperexpression in Streptomyces spp.
Applied and environmental microbiology 1991;57(5):1386-93.
1991: Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Characterization of an operon encoding succinyl-CoA synthetase and malate dehydrogenase from Thermus flavus AT-62 and its expression in Escherichia coli.
Molecular & general genetics : MGG 1991;226(1-2):1-9.
1991: Makoto Nishiyama; Sueharu Horinouchi; M Kobayashi; T Nagasawa; H Yamada; T Beppu
Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23.
Journal of bacteriology 1991;173(8):2465-72.
1991: S K Hong; M Kito; T Beppu; Sueharu Horinouchi
Phosphorylation of the AfsR product, a global regulatory protein for secondary-metabolite formation in Streptomyces coelicolor A3(2).
Journal of bacteriology 1991;173(7):2311-8.
1991: R Hiramatsu; Sueharu Horinouchi; T Beppu
Isolation and characterization of human pro-urokinase and its mutants accumulated within the yeast secretory pathway.
Gene 1991;99(2):235-41.
1991: Yuichi Hashimoto; Makoto Nishiyama; O Ikehata; Sueharu Horinouchi; T Beppu
Cloning and characterization of an amidase gene from Rhodococcus species N-774 and its expression in Escherichia coli.
Biochimica et biophysica acta 1991;1088(2):225-33.
1991: Atsushi Nakamura; F Fukumori; Sueharu Horinouchi; Haruhiko Masaki; Takashi Kudo; T Uozumi; K Horikoshi; T Beppu
Construction and characterization of the chimeric enzymes between the Bacillus subtilis cellulase and an alkalophilic Bacillus cellulase.
The Journal of biological chemistry 1991;266(3):1579-83.
1991: Kimihiko Abe; M Yoshida; T Usui; Sueharu Horinouchi; T Beppu
Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases.
Experimental cell research 1991;192(1):122-7.
1991: J Aikawa; R Hiramatsu; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
A yeast expression system and site-directed mutagenesis of a fungal aspartic proteinase, Mucor rennin.
Advances in experimental medicine and biology 1991;306():233-42.
1990: Sueharu Horinouchi; M Kito; M Nishiyama; K Furuya; S K Hong; K Miyake; T Beppu
Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2).
Gene 1990;95(1):49-56.
1990: J Suzuki; A Hamu; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Site-directed mutagenesis reveals functional contribution of Thr218, Lys220 and Asp304 in chymosin.
Protein engineering 1990;4(1):69-71.
1990: Sueharu Horinouchi; T Beppu
[Gene expression in Streptomyces].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1990;35(14):2567-83.
1990: J Aikawa; Takayuki Yamashita; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Effects of glycosylation on the secretion and enzyme activity of Mucor rennin, an aspartic proteinase of Mucor pusillus, produced by recombinant yeast.
The Journal of biological chemistry 1990;265(23):13955-9.
1990: R Hiramatsu; Takayuki Yamashita; J Aikawa; Sueharu Horinouchi; T Beppu
The prepro-peptide of Mucor rennin directs the secretion of human growth hormone by Saccharomyces cerevisiae.
Applied and environmental microbiology 1990;56(7):2125-32.
1990: K Miyake; T Kuzuyama; Sueharu Horinouchi; T Beppu
The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation.
Journal of bacteriology 1990;172(6):3003-8.
1990: Atsushi Nakamura; Y Koide; Fujio Kawamura; Sueharu Horinouchi; T Uozumi; T Beppu
Construction of a Bacillus subtilis strain deficient in three proteases.
Agricultural and biological chemistry 1990;54(5):1307-9.
1990: M Yoshida; M Nishikawa; K Nishi; Kimihiko Abe; Sueharu Horinouchi; T Beppu
Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells.
Experimental cell research 1990;187(1):150-6.
1990: M Azuma; K Nishi; Sueharu Horinouchi; T Beppu
Ribonucleases catalyze the synthesis of B-factor (3'-butylphosphoryl AMP), an inducer of rifamycin production in a Nocardia sp.
The Journal of antibiotics 1990;43(3):321-3.
1990: Sueharu Horinouchi; T Beppu
Autoregulatory factors of secondary metabolism and morphogenesis in actinomycetes.
Critical reviews in biotechnology 1990;10(3):191-204.
1989: H Miyazaki; N Yanagida; Sueharu Horinouchi; T Beppu
Characterization of the precursor of Serratia marcescens serine protease and COOH-terminal processing of the precursor during its excretion through the outer membrane of Escherichia coli.
Journal of bacteriology 1989;171(12):6566-72.
1989: R Hiramatsu; J Aikawa; Sueharu Horinouchi; T Beppu
Secretion by yeast of the zymogen form of Mucor rennin, an aspartic proteinase of Mucor pusillus, and its conversion to the mature form.
The Journal of biological chemistry 1989;264(28):16862-6.
1989: T Tamaki; Sueharu Horinouchi; MASAHIRO FUKAYA; H Okumura; Y Kawamura; T Beppu
Nucleotide sequence of the membrane-bound aldehyde dehydrogenase gene from Acetobacter polyoxogenes.
Journal of biochemistry 1989;106(4):541-4.
1989: K Miyake; Sueharu Horinouchi; M Yoshida; N Chiba; K Mori; N Nogawa; N Morikawa; T Beppu
Detection and properties of A-factor-binding protein from Streptomyces griseus.
Journal of bacteriology 1989;171(8):4298-302.
1989: O Ikehata; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Primary structure of nitrile hydratase deduced from the nucleotide sequence of a Rhodococcus species and its expression in Escherichia coli.
European journal of biochemistry / FEBS 1989;181(3):563-70.
1989: J Suzuki; K Sasaki; Y Sasao; A Hamu; H Kawasaki; Makoto Nishiyama; Sueharu Horinouchi; T Beppu
Alteration of catalytic properties of chymosin by site-directed mutagenesis.
Protein engineering 1989;2(7):563-9.
1989: Sueharu Horinouchi; H Suzuki; Makoto Nishiyama; T Beppu
Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis.
Journal of bacteriology 1989;171(2):1206-10.
1989: K Nakata; Sueharu Horinouchi; T Beppu
Cloning and characterization of the carbapenem biosynthetic genes from Streptomyces fulvoviridis.
FEMS microbiology letters 1989;48(1):51-5.
1989: Sueharu Horinouchi; F Malpartida; D A Hopwood; T Beppu
afsB stimulates transcription of the actinorhodin biosynthetic pathway in Streptomyces coelicolor A3(2) and Streptomyces lividans.
Molecular & general genetics : MGG 1989;215(2):355-7.
1988: Sueharu Horinouchi; S Fukusumi; T Ohshima; T Beppu
Cloning and expression in Escherichia coli of two additional amylase genes of a strictly anaerobic thermophile, Dictyoglomus thermophilum, and their nucleotide sequences with extremely low guanine-plus-cytosine contents.
European journal of biochemistry / FEBS 1988;176(2):243-53.
1988: R Nakai; Sueharu Horinouchi; T Beppu
Cloning and nucleotide sequence of a cellulase gene, casA, from an alkalophilic Streptomyces strain.
Gene 1988;65(2):229-38.
1988: S Fukusumi; A Kamizono; Sueharu Horinouchi; T Beppu
Cloning and nucleotide sequence of a heat-stable amylase gene from an anaerobic thermophile, Dictyoglomus thermophilum.
European journal of biochemistry / FEBS 1988;174(1):15-21.
1988: T Kawaguchi; M Azuma; Sueharu Horinouchi; T Beppu
Effect of B-factor and its analogues on rifamycin biosynthesis in Nocardia sp.
The Journal of antibiotics 1988;41(3):360-5.
1987: Sueharu Horinouchi; Makoto Nishiyama; Atsushi Nakamura; T Beppu
Construction and characterization of multicopy expression-vectors in Streptomyces spp.
Molecular & general genetics : MGG 1987;210(3):468-75.