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Seikoh Horiuchi

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Akihiro Kakehashi; S Inoda; Chiho Mameuda; Masatoshi Kuroki; Tadashi Jono; Ryuji Nagai; Seikoh Horiuchi; Masanobu Kawakami; Yasunori Kanazawa
Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy.
Hitomi Usui; Kenichi Shikata; Motofumi Sasaki; Shinichi Okada; Mitsuhiro Matsuda; Yasushi Shikata; Daisuke Ogawa; Yuichi Kido; Ryo Nagase; Kosuke Yozai; Sakiko Ohga; Atsuhito Tone; Jun Wada; Motohiro Takeya; Masahiro Takeya; Seikoh Horiuchi; Tatsuhiko Kodama; Hirofumi Makino
Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation.
Yuka Unno; Teruo Akuta; Yu-ichiro Sakamoto; Seikoh Horiuchi; Takaaki Akaike
Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes.

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2008: Akihiro Kakehashi; S Inoda; Chiho Mameuda; Masatoshi Kuroki; Tadashi Jono; Ryuji Nagai; Seikoh Horiuchi; Masanobu Kawakami; Yasunori Kanazawa
Relationship among VEGF, VEGF receptor, AGEs, and macrophages in proliferative diabetic retinopathy.
Diabetes research and clinical practice 2008;79(3):438-45.
2007: Hitomi Usui; Kenichi Shikata; Motofumi Sasaki; Shinichi Okada; Mitsuhiro Matsuda; Yasushi Shikata; Daisuke Ogawa; Yuichi Kido; Ryo Nagase; Kosuke Yozai; Sakiko Ohga; Atsuhito Tone; Jun Wada; Motohiro Takeya; Masahiro Takeya; Seikoh Horiuchi; Tatsuhiko Kodama; Hirofumi Makino
Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation.
Diabetes 2007;56(2):363-72.
2006: Yuka Unno; Teruo Akuta; Yu-ichiro Sakamoto; Seikoh Horiuchi; Takaaki Akaike
Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2006;15(2):125-32.
2006: Nahoko Nakano; Kaori Fukuhara-Takaki; Tadashi Jono; Keisuke Nakajou; Nobuaki ETO; Seikoh Horiuchi; Motohiro Takeya; Ryoji Nagai
Association of advanced glycation end products with A549 cells, a human pulmonary epithelial cell line, is mediated by a receptor distinct from the scavenger receptor family and RAGE.
Journal of biochemistry 2006;139(5):821-9.
2006: Yuichi Kaji; Tetsuro Oshika; Shiro Amano; Fumiki Okamoto; Wakako Koito; Seikoh Horiuchi
Immunohistochemical localization of advanced glycation end products in pinguecula.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2006;244(1):104-8.
2005: Yu-ichiro Sakamoto; Akira Miyazaki; Harumi Tamagawa; Guo-Ping Wang; Seikoh Horiuchi
Specific interaction of oxidized low-density lipoprotein with thrombospondin-1 inhibits transforming growth factor-beta from its activation.
Atherosclerosis 2005;183(1):85-93.
2005: Yuka Unno; Masakazu Sakai; Yu-Ichiro Sakamoto; Akihiko Kuniyasu; Ryoji Nagai; Hitoshi Nakayama; Seikoh Horiuchi
Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway.
Annals of the New York Academy of Sciences 2005;1043():696-701.
2005: Seikoh Horiuchi; Yuka Unno; Hitomi Usui; Kenichi Shikata; Kaori Takaki; Wakako Koito; Yu-Ichiro Sakamoto; Ryoji Nagai; Kenji Makino; Akira Sasao; Jun Wada; Hirofumi Makino
Pathological roles of advanced glycation end product receptors SR-A and CD36.
Annals of the New York Academy of Sciences 2005;1043():671-5.
2005: Keisuke Nakajou; Seikoh Horiuchi; Masakazu Sakai; Kenshiro Hirata; Makiko Tanaka; Motohiro Takeya; Toshiya Kai; Masaki Otagiri
CD36 is not involved in scavenger receptor-mediated endocytic uptake of glycolaldehyde- and methylglyoxal-modified proteins by liver endothelial cells.
Journal of biochemistry 2005;137(5):607-16.
2005: Motoko Kawaguchi; Noriyuki Shibata; Seikoh Horiuchi; Makio Kobayashi
Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes.
Neuropathology : official journal of the Japanese Society of Neuropathology 2005;25(1):27-36.
2005: Kaori Fukuhara-Takaki; Masakazu Sakai; Yu-ichiro Sakamoto; Motohiro Takeya; Seikoh Horiuchi
Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes.
The Journal of biological chemistry 2005;280(5):3355-64.
2005: Keisuke Nakajou; Seikoh Horiuchi; Masakazu Sakai; Nozomu Haraguchi; M Tanaka; Motohiro Takeya; Masaki Otagiri
Renal clearance of glycolaldehyde- and methylglyoxal-modified proteins in mice is mediated by mesangial cells through a class A scavenger receptor (SR-A).
Diabetologia 2005;48(2):317-27.
2005: N Matsunaga; Intissar Anan; P Rosenberg; Ryoji Nagai; O Lundström; Seikoh Horiuchi; Yukio Ando; Ole B Suhr
Advanced glycation end product is implicated in amyloid-related kidney complications.
Scandinavian journal of clinical and laboratory investigation 2005;65(4):263-71.
2004: Yuka Unno; Masakazu Sakai; Yu-Ichiro Sakamoto; Akihiko Kuniyasu; Hitoshi Nakayama; Ryoji Nagai; Seikoh Horiuchi
Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36.
Biochemical and biophysical research communications 2004;325(1):151-6.
2004: Wakako Koito; Tomohiro Araki; Seikoh Horiuchi; Ryoji Nagai
Conventional antibody against Nepsilon-(carboxymethyl)lysine (CML) shows cross-reaction to Nepsilon-(carboxyethyl)lysine (CEL): immunochemical quantification of CML with a specific antibody.
Journal of biochemistry 2004;136(6):831-7.
2004: Shinjiro Kobayashi; Miho Suzuki; Hiroshi Tsuneki; Ryoji Nagai; Seikoh Horiuchi; Nobuyoshi Hagino
Overproduction of N(epsilon)-(carboxymethyl)lysine-induced neovascularization in cultured choroidal explant of streptozotocin-diabetic rat.
Biological & pharmaceutical bulletin 2004;27(10):1565-71.
2004: Tadashi Jono; Ryoji Nagai; Xia Lin; Naila Ahmed; Paul J Thornalley; Motohiro Takeya; Seikoh Horiuchi
Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosone.
Journal of biochemistry 2004;136(3):351-8.
2004: Shinjiro Kobayashi; Harumichi Shinohara; Hiroshi Tsuneki; Ryoji Nagai; Seikoh Horiuchi
N(epsilon)-(carboxymethyl)lysine proliferated CD34(+) cells from rat choroidal explant in culture.
Biological & pharmaceutical bulletin 2004;27(9):1382-7.
2004: Masaharu Hori; Maki Satoh; Kohichiro Furukawa; Yu-ichiro Sakamoto; Hideki Hakamata; Yoshihiro Komohara; Motohiro Takeya; Yutaka Sasaki; Akira Miyazaki; Seikoh Horiuchi
Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1689-95.
2004: Noriko Uesugi; Noriyuki Sakata; Masaomi Nangaku; Masatoshi Abe; Seikoh Horiuchi; Satoshi Hisano; Hiroshi Iwasaki
Possible mechanism for medial smooth muscle cell injury in diabetic nephropathy: glycoxidation-mediated local complement activation.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2004;44(2):224-38.
2004: Masaharu Hori; Akira Miyazaki; Harumi Tamagawa; Maki Satoh; Kohichiro Furukawa; Hideki Hakamata; Yutaka Sasaki; Seikoh Horiuchi
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages.
Biochemical and biophysical research communications 2004;320(2):501-5.
2004: Kohichiro Furukawa; Masaharu Hori; Noriyuki Ouchi; Shinji Kihara; Tohru Funahashi; Yuji Matsuzawa; Akira Miyazaki; Hitoshi Nakayama; Seikoh Horiuchi
Adiponectin down-regulates acyl-coenzyme A:cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages.
Biochemical and biophysical research communications 2004;317(3):831-6.
2004: Hirohito Sone; Hitoshi Shimano; Miao Shu; Masanori Nakakuki; Akimitsu Takahashi; Masakazu Sakai; Yuichiro Sakamoto; Takashi Yokoo; Ken Matsuzaka; Hiroaki Okazaki; Yoshimi Nakagawa; Kaoruko Tada Iida; Hiroaki Suzuki; Hideo Toyoshima; Seikoh Horiuchi; Nobuhiro Yamada
Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages.
Biochemical and biophysical research communications 2004;316(3):790-4.
2004: Wenri Zhang; Keiko Sato; Takeshi Hayashi; Nobuhiko Omori; Isao Nagano; Shinsuke Kato; Seikoh Horiuchi; Koji Abe
Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain.
Neurological research 2004;26(3):342-8.
2004: Akira Moh; Noriyuki Sakata; Shigeo Takebayashi; Kayoko Tateishi; Ryoji Nagai; Seikoh Horiuchi; Junichi Chihara
Increased production of urea hydrogen peroxide from Maillard reaction and a UHP-Fenton pathway related to glycoxidation damage in chronic renal failure.
Journal of the American Society of Nephrology : JASN 2004;15(4):1077-85.
2004: Nobuyoshi Hagino; Shinjiro Kobayashi; Taiki Tsutsumi; Seikoh Horiuchi; Ryoji Nagai; Gyury Setalo; Erizabet Dettrich
Vascular change of hippocampal capillary is associated with vascular change of retinal capillary in aging.
Brain research bulletin 2004;62(6):537-47.
2004: Weiguo Li; Yoji Hamada; Eitaro Nakashima; Keiko Naruse; Hideki Kamiya; Noboru Akiyama; Hiroko Hirooka; Naoki Takahashi; Seikoh Horiuchi; Nigishi Hotta; Yutaka Oiso; Jiro Nakamura
Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells.
Biochemical and biophysical research communications 2004;314(2):370-6.
2003: Seikoh Horiuchi; Yu-ichiro Sakamoto; Masakazu Sakai
Scavenger receptors for oxidized and glycated proteins.
Amino acids 2003;25(3-4):283-92.
2003: Ryoji Nagai; Seikoh Horiuchi; Yuka Unno
Application of monoclonal antibody libraries for the measurement of glycation adducts.
Biochemical Society transactions 2003;31(Pt 6):1438-40.
2003: Gunther Marsche; Robert Zimmermann; Seikoh Horiuchi; Narendra Tandon; Wolfgang Sattler; Ernst Malle
Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein.
The Journal of biological chemistry 2003;278(48):47562-70.
2003: Noriyuki Sakata; Kazuma Takeuchi; Keita Noda; Keijiro Saku; Yutaka Tachikawa; Tadashi Tashiro; Ryoji Nagai; Seikoh Horiuchi
Calcification of the medial layer of the internal thoracic artery in diabetic patients: relevance of glycoxidation.
Journal of vascular research 2003;40(6):567-74.
2003: Naomi Sakashita; Akira Miyazaki; Catherine C Y Chang; Ta-Yuan Chang; Emi Kiyota; Maki Satoh; Yoshihiro Komohara; Peter M Morganelli; Seikoh Horiuchi; Motohiro Takeya
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies.
Laboratory investigation; a journal of technical methods and pathology 2003;83(11):1569-81.
2003: Dmitri Svistounov; Tore J Berg; Peter A G McCourt; Svetlana N Zykova; Kjetil Elvevold; Ryoji Nagai; Seikoh Horiuchi; Bard H Smedsrod
Lack of recognition of Nepsilon-(carboxymethyl)lysine by the mouse liver reticulo-endothelial system: implications for pathophysiology.
Biochemical and biophysical research communications 2003;309(4):786-91.
2003: Masakazu Sakai; Yu-ichiro Sakamoto; Seikoh Horiuchi
[The mechanisms of the development and progression of diabetic macrovascular complications].
Clinical calcium 2003;13(9):1143-8.
2003: Akira Miyazaki; Masakazu Sakai; Yuichiro Sakamoto; Seikoh Horiuchi
Acyl-coenzyme A:cholesterol acyltransferase inhibitors for controlling hypercholesterolemia and atherosclerosis.
Current opinion in investigational drugs (London, England : 2000) 2003;4(9):1095-9.
2003: Noriyuki Sakata; Akiko Noma; Yuji Yamamoto; Kouji Okamoto; Jing Meng; Shigeo Takebayashi; Ryoji Nagai; Seikoh Horiuchi
Modification of elastin by pentosidine is associated with the calcification of aortic media in patients with end-stage renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(8):1601-9.
2003: Ryoji Nagai; Tomohiro Araki; Cristina Miki Hayashi; Fumitaka Hayase; Seikoh Horiuchi
Identification of N epsilon-(carboxyethyl)lysine, one of the methylglyoxal-derived AGE structures, in glucose-modified protein: mechanism for protein modification by reactive aldehydes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;788(1):75-84.
2003: Akihiko Saito; Ryoji Nagai; Atsuhito Tanuma; Hitomi Hama; Kenji Cho; Tetsuro Takeda; Yutaka Yoshida; Tosifusa Toda; Fujio Shimizu; Seikoh Horiuchi; Fumitake Gejyo
Role of megalin in endocytosis of advanced glycation end products: implications for a novel protein binding to both megalin and advanced glycation end products.
Journal of the American Society of Nephrology : JASN 2003;14(5):1123-31.
2003: Akihiko Kuniyasu; Nobutaka Ohgami; Shigeki Hayashi; Akira Miyazaki; Seikoh Horiuchi; Hitoshi Nakayama
CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes.
FEBS letters 2003;537(1-3):85-90.
2003: Nobutaka Ohgami; Akira Miyazaki; Masakazu Sakai; Akihiko Kuniyasu; Hitoshi Nakayama; Seikoh Horiuchi
Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism.
Journal of atherosclerosis and thrombosis 2003;10(1):1-6.
2002: Ryoji Nagai; Cristina Miki Hayashi; Ling Xia; Motohiro Takeya; Seikoh Horiuchi
Identification in human atherosclerotic lesions of GA-pyridine, a novel structure derived from glycolaldehyde-modified proteins.
The Journal of biological chemistry 2002;277(50):48905-12.
2002: Noriko Matsunaga; Intissar Anan; Sture Forsgren; Ryoji Nagai; Peter Rosenberg; Seikoh Horiuchi; Yukio Ando; Ole B Suhr
Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation.
Acta neuropathologica 2002;104(5):441-7.
2002: Berit Hansen; Dmitri Svistounov; Randi Olsen; R Nagai; Seikoh Horiuchi; Bård Smedsrød
Advanced glycation end products impair the scavenger function of rat hepatic sinusoidal endothelial cells.
Diabetologia 2002;45(10):1379-88.
2002: Kiminori Miyazaki; Ryoji Nagai; Seikoh Horiuchi
Creatine plays a direct role as a protein modifier in the formation of a novel advanced glycation end product.
Journal of biochemistry 2002;132(4):543-50.
2002: Tadashi Jono; Takemi Kimura; Junichi Takamatsu; Ryoji Nagai; Kiminori Miyazaki; Takefumi Yuzuriha; Toshinori Kitamura; Seikoh Horiuchi
Accumulation of imidazolone, pentosidine and N(epsilon)-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain.
Pathology international 2002;52(9):563-71.
2002: Ryoji Nagai; Yuka Unno; Miki Cristina Hayashi; Shuichi Masuda; Fumitaka Hayase; Naohide Kinae; Seikoh Horiuchi
Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.
Diabetes 2002;51(9):2833-9.
2002: Yoshiyuki Miyahara; Satoshi Ikeda; Takahiro Muroya; Chie Yasuoka; Yoshishige Urata; Seikoh Horiuchi; Shigeru Kohno; Takahito Kondo
Nepsilon-(Carboxymethyl)lysine induces gamma-glutamylcysteine synthetase in RAW264.7 cells.
Biochemical and biophysical research communications 2002;296(1):32-40.
2002: Akira Miyazaki; Hitoshi Nakayama; Seikoh Horiuchi
Scavenger receptors that recognize advanced glycation end products.
Trends in cardiovascular medicine 2002;12(6):258-62.
2002: Mehtap Yuksel; Kenji Okajima; Mitsuhiro Uchiba; Seikoh Horiuchi; Hiroaki Okabe
Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes.
Thrombosis and haemostasis 2002;88(2):267-73.
2002: Noriyuki Shibata; Asao Hirano; E Tessa Hedley-Whyte; Mauro C Dal Canto; Ryoji Nagai; Koji Uchida; Seikoh Horiuchi; Motoko Kawaguchi; Tomoko Yamamoto; Makio Kobayashi
Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation.
Acta neuropathologica 2002;104(2):171-8.
2002: Cristina Miki Hayashi; Ryoji Nagai; Kiminori Miyazaki; Fumitaka Hayase; Tomohiro Araki; Tomomichi Ono; Seikoh Horiuchi
Conversion of Amadori products of the Maillard reaction to N(epsilon)-(carboxymethyl)lysine by short-term heating: possible detection of artifacts by immunohistochemistry.
Laboratory investigation; a journal of technical methods and pathology 2002;82(6):795-808.
2002: Yoshishige Urata; Michiko Yamaguchi; Yasuhito Higashiyama; Yoshito Ihara; Shinji Goto; Michihiko Kuwano; Seikoh Horiuchi; Koji Sumikawa; Takahito Kondo
Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages.
Free radical biology & medicine 2002;32(8):688-701.
2002: Tadashi Jono; Akira Miyazaki; Ryoji Nagai; Tatsuya Sawamura; Toshinori Kitamura; Seikoh Horiuchi
Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE).
FEBS letters 2002;511(1-3):170-4.
2002: Michiyo Tsuru; Kensei Nagata; Atsuo Jimi; Kouji Irie; Akira Yamada; Ryoji Nagai; Seikoh Horiuchi; Michio Sata
Effect of AGEs on human disc herniation: intervertebral disc hernia is also effected by AGEs.
The Kurume medical journal 2002;49(1-2):7-13.
2002: Nobutaka Ohgami; Ryoji Nagai; Mamoru Ikemoto; Hiroyuki Arai; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Hitoshi Nakayama
CD36, serves as a receptor for advanced glycation endproducts (AGE).
Journal of diabetes and its complications 2002;16(1):56-9.
2002: Seikoh Horiuchi
The liver is the main site for metabolism of circulating advanced glycation end products.
Journal of hepatology 2002;36(1):123-5.
2001: Yuichi Kaji; Shiro Amano; Tomohiko Usui; Kaori Suzuki; Sumiyoshi Tanaka; Tetsuro Oshika; Ryozo Nagai; Seikoh Horiuchi
Advanced glycation end products in Descemet's membrane and their effect on corneal endothelial cell.
Current eye research 2001;23(6):469-77.
2001: Nobutaka Ohgami; Ryoji Nagai; Mamoru Ikemoto; Hiroyuki Arai; Akihiko Kuniyasu; Seikoh Horiuchi; Hitoshi Nakayama
CD36, a member of class B scavenger receptor family, is a receptor for advanced glycation end products.
Annals of the New York Academy of Sciences 2001;947():350-5.
2001: Noriko Uesugi; Noriyuki Sakata; Seikoh Horiuchi; R Nagai; M Takeya; J Meng; Takao Saito; Shigeo Takebayashi
Glycoxidation-modified macrophages and lipid peroxidation products are associated with the progression of human diabetic nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(5):1016-25.
2001: X Ling; Ryoji Nagai; Naomi Sakashita; Motohiro Takeya; Seikoh Horiuchi; Kiyoshi Takahashi
Immunohistochemical distribution and quantitative biochemical detection of advanced glycation end products in fetal to adult rats and in rats with streptozotocin-induced diabetes.
Laboratory investigation; a journal of technical methods and pathology 2001;81(6):845-61.
2001: J Meng; Noriyuki Sakata; Y Imanaga; Shigeo Takebayashi; Ryoji Nagai; Seikoh Horiuchi
Carboxymethyllysine in dermal tissues of diabetic and nondiabetic patients with chronic renal failure: relevance to glycoxidation damage.
Nephron 2001;88(1):30-5.
2001: Nobutaka Ohgami; Ryoji Nagai; Akira Miyazaki; Mamoru Ikemoto; Hiroyuki Arai; Seikoh Horiuchi; Hitoshi Nakayama
Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products.
The Journal of biological chemistry 2001;276(16):13348-55.
2001: Akira Miyazaki; Seikoh Horiuchi
[ACAT inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():675-80.
2001: Nobutaka Ohgami; Ryoji Nagai; Hitoshi Nakayama; Seikoh Horiuchi
[AGE and AGE-receptors].
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(3):200-4.
2001: W Zhu; H Sano; Ryoji Nagai; K Fukuhara; Akira Miyazaki; Seikoh Horiuchi
The role of galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteins.
Biochemical and biophysical research communications 2001;280(4):1183-8.
2001: Nobutaka Ohgami; Ryoji Nagai; Mamoru Ikemoto; Hiroyuki Arai; Akihiko Kuniyasu; Seikoh Horiuchi; Hitoshi Nakayama
Cd36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products.
The Journal of biological chemistry 2001;276(5):3195-202.
2001: Akira Miyazaki; Seikoh Horiuchi
[Molecular mechanisms for macrophage foam cell formation].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():591-5.
2001: Akira Miyazaki; Seikoh Horiuchi
[Regulation of lipid metabolism in macrophages].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():451-6.
2001: Akira Miyazaki; Seikoh Horiuchi
[Acyl-CoA: cholesterol acyltransferase (ACAT)].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():219-23.
2001: KK Maung; Akira Miyazaki; H Nomiyama; Catherine C Y Chang; Ta-Yuan Chang; Seikoh Horiuchi
Induction of acyl-coenzyme A:cholesterol acyltransferase-1 by 1,25-dihydroxyvitamin D(3) or 9-cis-retinoic acid in undifferentiated THP-1 cells.
Journal of lipid research 2001;42(2):181-7.
2001: Noriyuki Sakata; Noriko Uesugi; Shigeo Takebayashi; R Nagai; T Jono; Seikoh Horiuchi; M Takeya; Hiroyuki Itabe; T Takano; T Myint; N Taniguchi
Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis.
Cardiovascular research 2001;49(2):466-75.
2001: Shiro Amano; Yuichi Kaji; Tetsuro Oshika; T Oka; Rikuo Machinami; R Nagai; Seikoh Horiuchi
Advanced glycation end products in human optic nerve head.
The British journal of ophthalmology 2001;85(1):52-5.
2000: Kazuya Matsumoto; H Sano; Ryoji Nagai; Hiroshi Suzuki; Tatsuhiko Kodama; M Yoshida; Shoichi Ueda; B Smedsrød; Seikoh Horiuchi
Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage scavenger receptor class A.
The Biochemical journal 2000;352 Pt 1():233-40.
2000: Nobutaka Ohgami; Akihiko Kuniyasu; Kohichiro Furukawa; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Hitoshi Nakayama
Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme.
Biochemical and biophysical research communications 2000;277(2):417-22.
2000: Masakazu Sakai; S Kobori; Akira Miyazaki; Seikoh Horiuchi
Macrophage proliferation in atherosclerosis.
Current opinion in lipidology 2000;11(5):503-9.
2000: Yoji Hamada; Jiro Nakamura; Keiko Naruse; T Komori; Kanefusa Kato; Yasuhide Kasuya; R Nagai; Seikoh Horiuchi; Nigishi Hotta
Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.
Diabetes care 2000;23(10):1539-44.
2000: Ryoji Nagai; Kazuya Matsumoto; X Ling; Hiroshi Suzuki; Tomohiro Araki; Seikoh Horiuchi
Glycolaldehyde, a reactive intermediate for advanced glycation end products, plays an important role in the generation of an active ligand for the macrophage scavenger receptor.
Diabetes 2000;49(10):1714-23.
2000: Noriyuki Shibata; Ryoji Nagai; S Miyata; T Jono; Seikoh Horiuchi; Asao Hirano; S Kato; Shoichi Sasaki; K Asayama; Makio Kobayashi
Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation.
Acta neuropathologica 2000;100(3):275-84.
2000: Y Imanaga; Noriyuki Sakata; Shigeo Takebayashi; Akira Matsunaga; Jun Sasaki; Kikuo Arakawa; Ryoji Nagai; Seikoh Horiuchi; Hiroyuki Itabe; T Takano
In vivo and in vitro evidence for the glycoxidation of low density lipoprotein in human atherosclerotic plaques.
Atherosclerosis 2000;150(2):343-55.
2000: Akira Miyazaki; T Biwa; Hideki Hakamata; Masakazu Sakai; Yu-Ichiro Sakamoto; KK Maung; M Yuksel; Seikoh Horiuchi
Granulocyte macrophage colony-stimulating factor plays a priming role in murine macrophage growth induced by oxidized low density lipoprotein.
Annals of the New York Academy of Sciences 2000;902():342-6.
2000: N Nyhlin; Yukio Ando; Ryoji Nagai; Ole B Suhr; M El Sahly; Hisayasu Terazaki; Takeshi Yamashita; Masayuki Ando; Seikoh Horiuchi
Advanced glycation end product in familial amyloidotic polyneuropathy (FAP).
Journal of internal medicine 2000;247(4):485-92.
2000: Noriko Uesugi; Noriyuki Sakata; Ryoji Nagai; T Jono; Seikoh Horiuchi; Shigeo Takebayashi
Glycoxidative modification of AA amyloid deposits in renal tissue.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2000;15(3):355-65.
2000: T Biwa; Masakazu Sakai; Takeshi Matsumura; S Kobori; K Kaneko; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
Sites of action of protein kinase C and phosphatidylinositol 3-kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation.
The Journal of biological chemistry 2000;275(8):5810-6.
2000: Yuichi Kaji; Tomohiko Usui; Tetsuro Oshika; M Matsubara; Hidetoshi Yamashita; Makoto Araie; T Murata; T Ishibashi; Ryozo Nagai; Seikoh Horiuchi; Shiro Amano
Advanced glycation end products in diabetic corneas.
Investigative ophthalmology & visual science 2000;41(2):362-8.
2000: T Biwa; Masakazu Sakai; Motoaki Shichiri; Seikoh Horiuchi
Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation.
Journal of atherosclerosis and thrombosis 2000;7(1):14-20.
2000: Noriyuki Sakata; Yoshie Sasatomi; J Meng; S Ando; Noriko Uesugi; Shigeo Takebayashi; Ryoji Nagai; Seikoh Horiuchi
Possible involvement of altered RGD sequence in reduced adhesive and spreading activities of advanced glycation end product-modified fibronectin to vascular smooth muscle cells.
Connective tissue research 2000;41(3):213-28.
2000: Naomi Sakashita; Akira Miyazaki; Motohiro Takeya; Seikoh Horiuchi; Catherine C Y Chang; Ta-Yuan Chang; Kiyoshi Takahashi
Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues.
The American journal of pathology 2000;156(1):227-36.
1999: Akira Miyazaki; Seikoh Horiuchi
[Development of new antiatherosclerotic agents--ACAT inhibitors and CETP inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(12):2842-7.
1999: Hitoshi Nakayama; Nobutaka Ohgami; Akihiko Kuniyasu; Akira Miyazaki; Hideki Hakamata; Seikoh Horiuchi
[Glibenclamide inhibits cholesterol metabolism in macrophage].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():150P-153P.
1999: R Shibayama; N Araki; Ryoji Nagai; Seikoh Horiuchi
Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.
Diabetes 1999;48(9):1842-9.
1999: Akira Miyazaki; Seikoh Horiuchi
[Roles of acyl-coenzyme A: cholesterol acyltransferase (ACAT) isozymes].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(8 Suppl):1312-8.
1999: H Han; Jun Sasaki; Akira Matsunaga; H Hakamata; Wei Huang; M Ageta; T Taguchi; Tetsuya Koga; M Kugi; Seikoh Horiuchi; Kikuo Arakawa
A novel mutant, ApoA-I nichinan (Glu235-->0), is associated with low HDL cholesterol levels and decreased cholesterol efflux from cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(6):1447-55.
1999: Seikoh Horiuchi; H Takikawa; Kenji Mori
Enzymatic resolution of (+/-)-gamma-cyclohomogeraniol and conversion of its (S)-isomer to (S)-gamma-coronal, the ambergris odorant.
Bioorganic & medicinal chemistry 1999;7(5):723-6.
1999: H Sano; Ryoji Nagai; Kazuya Matsumoto; Seikoh Horiuchi
Receptors for proteins modified by advanced glycation endproducts (AGE)--their functional role in atherosclerosis.
Mechanisms of ageing and development 1999;107(3):333-46.
1999: Noriyuki Shibata; Asao Hirano; S Kato; Ryoji Nagai; Seikoh Horiuchi; T Komori; T Umahara; K Asayama; Makio Kobayashi
Advanced glycation endproducts are deposited in neuronal hyaline inclusions: a study on familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation.
Acta neuropathologica 1999;97(3):240-6.
1999: Noriyuki Sakata; Y Imanaga; J Meng; Yutaka Tachikawa; Shigeo Takebayashi; Ryoji Nagai; Seikoh Horiuchi
Increased advanced glycation end products in atherosclerotic lesions of patients with end-stage renal disease.
Atherosclerosis 1999;142(1):67-77.
1998: X Ling; Naomi Sakashita; Motohiro Takeya; Ryoji Nagai; Seikoh Horiuchi; Kiyoshi Takahashi
Immunohistochemical distribution and subcellular localization of three distinct specific molecular structures of advanced glycation end products in human tissues.
Laboratory investigation; a journal of technical methods and pathology 1998;78(12):1591-606.
1998: Noriyuki Sakata; Y Imanaga; J Meng; Yutaka Tachikawa; Shigeo Takebayashi; Ryoji Nagai; Seikoh Horiuchi; Hiroyuki Itabe; T Takano
Immunohistochemical localization of different epitopes of advanced glycation end products in human atherosclerotic lesions.
Atherosclerosis 1998;141(1):61-75.
1998: T Biwa; Hideki Hakamata; Masakazu Sakai; Akira Miyazaki; H Suzuki; T Kodama; Motoaki Shichiri; Seikoh Horiuchi
Induction of murine macrophage growth by oxidized low density lipoprotein is mediated by granulocyte macrophage colony-stimulating factor.
The Journal of biological chemistry 1998;273(43):28305-13.
1998: Akira Miyazaki; Naomi Sakashita; Oneil Lee; Kiyoshi Takahashi; Seikoh Horiuchi; Hideki Hakamata; Peter M Morganelli; Catherine C Y Chang; Ta-Yuan Chang
Expression of ACAT-1 protein in human atherosclerotic lesions and cultured human monocytes-macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1568-74.
1998: Hideki Hakamata; H Sakaguchi; C Zhang; Naomi Sakashita; Hiroshi Suzuki; Akira Miyazaki; Motohiro Takeya; Kiyoshi Takahashi; N Kitamura; Seikoh Horiuchi
The very low- and intermediate-density lipoprotein fraction isolated from apolipoprotein E-knockout mice transforms macrophages to foam cells through an apolipoprotein E-independent pathway.
Biochemistry 1998;37(39):13720-7.
1998: T Kimura; J Takamatsu; T Miyata; Toshikazu Miyakawa; Seikoh Horiuchi
Localization of identified advanced glycation end-product structures, N epsilon(carboxymethyl)lysine and pentosidine, in age-related inclusions in human brains.
Pathology international 1998;48(8):575-9.
1998: T Matsuse; Eijiro Ohga; S Teramoto; Masashi Fukayama; Ryozo Nagai; Seikoh Horiuchi; Y Ouchi
Immunohistochemical localisation of advanced glycation end products in pulmonary fibrosis.
Journal of clinical pathology 1998;51(7):515-9.
1998: Kyoji Ikeda; Ryoji Nagai; T Sakamoto; H Sano; Tomohiro Araki; N Sakata; Hitoshi Nakayama; M Yoshida; Shoichi Ueda; Seikoh Horiuchi
Immunochemical approaches to AGE-structures: characterization of anti-AGE antibodies.
Journal of immunological methods 1998;215(1-2):95-104.
1998: Yoshiteru Jinnouchi; H Sano; Ryoji Nagai; Hideki Hakamata; Tatsuhiko Kodama; Hiroshi Suzuki; M Yoshida; Shoichi Ueda; Seikoh Horiuchi
Glycolaldehyde-modified low density lipoprotein leads macrophages to foam cells via the macrophage scavenger receptor.
Journal of biochemistry 1998;123(6):1208-17.
1998: H Sano; Toshihiro Higashi; Kazuya Matsumoto; J Melkko; Yoshiteru Jinnouchi; Kyoji Ikeda; Y Ebina; H Makino; B Smedsrod; Seikoh Horiuchi
Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of advanced glycation end products.
The Journal of biological chemistry 1998;273(15):8630-7.
1998: Masakazu Sakai; Motoaki Shichiri; Hideki Hakamata; Seikoh Horiuchi
Endocytosed lysophosphatidylcholine, through the scavenger receptor, plays an essential role in oxidized low-density lipoprotein-induced macrophage proliferation.
Trends in cardiovascular medicine 1998;8(3):119-24.
1998: H Sakaguchi; Motohiro Takeya; Hiroshi Suzuki; Hideki Hakamata; Tatsuhiko Kodama; Seikoh Horiuchi; S Gordon; Luc J van der Laan; Georg Kraal; S Ishibashi; N Kitamura; Kiyoshi Takahashi
Role of macrophage scavenger receptors in diet-induced atherosclerosis in mice.
Laboratory investigation; a journal of technical methods and pathology 1998;78(4):423-34.
1998: H Matsuda; Hideki Hakamata; T Kawasaki; Naomi Sakashita; Akira Miyazaki; Kiyoshi Takahashi; Motoaki Shichiri; Seikoh Horiuchi
Molecular cloning, functional expression and tissue distribution of rat acyl-coenzyme A:cholesterol acyltransferase.
Biochimica et biophysica acta 1998;1391(2):193-203.
1998: Ryoji Nagai; Kyoji Ikeda; Y Kawasaki; H Sano; M Yoshida; Tomohiro Araki; Shoichi Ueda; Seikoh Horiuchi
Conversion of Amadori product of Maillard reaction to Nepsilon-(carboxymethyl)lysine in alkaline condition.
FEBS letters 1998;425(2):355-60.
1998: T Kawasaki; Akira Miyazaki; Hideki Hakamata; H Matsuda; Seikoh Horiuchi
Biochemical evidence for oligomerization of rat adrenal acyl-coenzyme A:cholesterol acyltransferase.
Biochemical and biophysical research communications 1998;244(2):347-52.
1998: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; H Matsuda; Hiroshi Suzuki; Tatsuhiko Kodama; Seikoh Horiuchi
Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.
Journal of lipid research 1998;39(3):482-94.
1998: Y Ding; Hideki Hakamata; H Matsuda; Takayuki Kawano; T Kawasaki; Akira Miyazaki; Seikoh Horiuchi
Reduced expression of the macrophage scavenger receptors in macrophage-like cell mutants resistant to brefeldin A.
Biochemical and biophysical research communications 1998;243(1):277-83.
1998: J Meng; Noriyuki Sakata; Shigeo Takebayashi; T Asano; T Futata; Ryoji Nagai; K Ikeda; Seikoh Horiuchi; T Myint; N Taniguchi
Glycoxidation in aortic collagen from STZ-induced diabetic rats and its relevance to vascular damage.
Atherosclerosis 1998;136(2):355-65.
1998: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Yu-ichiro Sakamoto; Seikoh Horiuchi
Cytotoxic effect of oxidized low density lipoprotein on macrophages.
Journal of atherosclerosis and thrombosis 1998;5(2):66-75.
1997: Kazuya Matsumoto; Kyoji Ikeda; Seikoh Horiuchi; H Zhao; E C Abraham
Immunochemical evidence for increased formation of advanced glycation end products and inhibition by aminoguanidine in diabetic rat lenses.
Biochemical and biophysical research communications 1997;241(2):352-4.
1997: Kazuya Matsumoto; H Sano; Seikoh Horiuchi
[AGE receptor].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():867-71.
1997: Takeshi Matsumura; Masakazu Sakai; S Kobori; T Biwa; T Takemura; H Matsuda; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
Two intracellular signaling pathways for activation of protein kinase C are involved in oxidized low-density lipoprotein-induced macrophage growth.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):3013-20.
1997: Takayuki Kawano; Hideki Hakamata; T Ohta; Y Ding; M Yoshida; S Ueda; Seikoh Horiuchi
Inhibitory effects of HepG2 cell-derived apolipoprotein A-I-containing lipoproteins on cholesteryl ester accumulation in macrophages.
Biochemistry 1997;36(32):9816-25.
1997: Masakazu Sakai; S Kobori; Takeshi Matsumura; T Biwa; Y Sato; T Takemura; Hideki Hakamata; Seikoh Horiuchi; Motoaki Shichiri
HMG-CoA reductase inhibitors suppress macrophage growth induced by oxidized low density lipoprotein.
Atherosclerosis 1997;133(1):51-9.
1997: Ryoji Nagai; Kyoji Ikeda; Toshihiro Higashi; H Sano; Yoshiteru Jinnouchi; Tomohiro Araki; Seikoh Horiuchi
Hydroxyl radical mediates N epsilon-(carboxymethyl)lysine formation from Amadori product.
Biochemical and biophysical research communications 1997;234(1):167-72.
1997: K Mizutari; Tomomichi Ono; Kyoji Ikeda; Ken-ichi Kayashima; Seikoh Horiuchi
Photo-enhanced modification of human skin elastin in actinic elastosis by N(epsilon)-(carboxymethyl)lysine, one of the glycoxidation products of the Maillard reaction.
The Journal of investigative dermatology 1997;108(5):797-802.
1997: Masakazu Sakai; Takeshi Matsumura; T Biwa; Hideki Hakamata; D Yi; Motoaki Shichiri; Seikoh Horiuchi
Role of the macrophage scavenger receptor for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage growth.
Annals of the New York Academy of Sciences 1997;811():378-84.
1997: Bård Smedsrød; Jukka Melkko; N Araki; H Sano; Seikoh Horiuchi
Advanced glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells.
The Biochemical journal 1997;322 ( Pt 2)():567-73.
1997: Toshihiro Higashi; H Sano; Tetsushi Saishoji; Kyoji Ikeda; Yoshiteru Jinnouchi; T Kanzaki; N Morisaki; H Rauvala; Motoaki Shichiri; Seikoh Horiuchi
The receptor for advanced glycation end products mediates the chemotaxis of rabbit smooth muscle cells.
Diabetes 1997;46(3):463-72.
1996: T Kimura; Kyoji Ikeda; J Takamatsu; T Miyata; G Sobue; T Miyakawa; Seikoh Horiuchi
Identification of advanced glycation end products of the Maillard reaction in Pick's disease.
Neuroscience letters 1996;219(2):95-8.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Tatsuhiko Kodama; Hiroshi Suzuki; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
The scavenger receptor serves as a route for internalization of lysophosphatidylcholine in oxidized low density lipoprotein-induced macrophage proliferation.
The Journal of biological chemistry 1996;271(44):27346-52.
1996: Y Sato; S Kobori; Masakazu Sakai; T Yano; Toshihiro Higashi; Takeshi Matsumura; W Morikawa; T Terano; Akira Miyazaki; Seikoh Horiuchi; Motoaki Shichiri
Lipoprotein(a) induces cell growth in rat peritoneal macrophages through inhibition of transforming growth factor-beta activation.
Atherosclerosis 1996;125(1):15-26.
1996: J Meng; Noriyuki Sakata; Shigeo Takebayashi; T Asano; T Futata; N Araki; Seikoh Horiuchi
Advanced glycation end products of the Maillard reaction in aortic pepsin-insoluble and pepsin-soluble collagen from diabetic rats.
Diabetes 1996;45(8):1037-43.
1996: Seikoh Horiuchi
Advanced Glycation End Products (AGE)-Modified Proteins and Their Potential Relevance to Atherosclerosis.
Trends in cardiovascular medicine 1996;6(5):163-8.
1996: Seikoh Horiuchi; Toshihiro Higashi; Kyoji Ikeda; Tetsushi Saishoji; Yoshiteru Jinnouchi; H Sano; R Shibayama; T Sakamoto; Norie Araki
Advanced glycation end products and their recognition by macrophage and macrophage-derived cells.
Diabetes 1996;45 Suppl 3():S73-6.
1996: Kyoji Ikeda; Toshihiro Higashi; H Sano; Yoshiteru Jinnouchi; M Yoshida; Tomohiro Araki; Shoichi Ueda; Seikoh Horiuchi
N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction.
Biochemistry 1996;35(24):8075-83.
1996: H Matsuda; Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Catherine C Y Chang; Ta-Yuan Chang; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Activation of acyl-coenzyme A:cholesterol acyltransferase activity by cholesterol is not due to altered mRNA levels in HepG2 cells.
Biochimica et biophysica acta 1996;1301(1-2):76-84.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Y Sato; Takeshi Matsumura; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Lysophosphatidylcholine potentiates the mitogenic activity of modified LDL for human monocyte-derived macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(4):600-5.
1996: Y Suginohara; Akira Miyazaki; Hideki Hakamata; Y Sakamoto; T Ohta; I Matsuda; Seikoh Horiuchi
The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages.
Atherosclerosis 1996;120(1-2):167-79.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; Y Suginohara; Y I Sakamoto; W Morikawa; S Kobori; M Schichiri; Seikoh Horiuchi
Reconstituted high density lipoprotein reduces the capacity of oxidatively modified low density lipoprotein to accumulate cholesteryl esters in mouse peritoneal macrophages.
Atherosclerosis 1996;119(2):191-202.
1996: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; S Kobori; Motoaki Shichiri; Seikoh Horiuchi
Endocytic uptake of lysophosphatidylcholine mediated by macrophage scavenger receptor plays a major role in oxidized low density lipoprotein-induced macrophage growth.
Journal of atherosclerosis and thrombosis 1996;2(2):81-6.
1996: Seikoh Horiuchi; H Sano; Toshihiro Higashi; Kyoji Ikeda; Yoshiteru Jinnouchi; Ryoji Nagai; K Takahashi
Extra- and intracellular localization of advanced glycation end-products in human atherosclerotic lesions.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 5():81-6.
1995: Tetsushi Saishoji; Toshihiro Higashi; Kyoji Ikeda; H Sano; Yoshiteru Jinnouchi; M Ogawa; Seikoh Horiuchi
Advanced glycation end products stimulate plasminogen activator activity via GM-CSF in RAW 264.7 cells.
Biochemical and biophysical research communications 1995;217(1):278-85.
1995: T Mori; K Takahashi; Toshihiro Higashi; Motohiro Takeya; S Kume; Y Kawabe; Tatsuhiko Kodama; Seikoh Horiuchi
Localization of advanced glycation end products of Maillard reaction in bovine tissues and their endocytosis by macrophage scavenger receptors.
Experimental and molecular pathology 1995;63(2):135-52.
1995: S Kume; Motohiro Takeya; T Mori; Norie Araki; Hiroshi Suzuki; Seikoh Horiuchi; Tatsuhiko Kodama; Y Miyauchi; K Takahashi
Immunohistochemical and ultrastructural detection of advanced glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal antibody.
The American journal of pathology 1995;147(3):654-67.
1995: Norie Araki; Toshihiro Higashi; T Mori; R Shibayama; Y Kawabe; Tatsuhiko Kodama; K Takahashi; Motoaki Shichiri; Seikoh Horiuchi
Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction.
European journal of biochemistry / FEBS 1995;230(2):408-15.
1995: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Y I Sakamoto; H Matsuda; K Kihara; Seikoh Horiuchi
Differential effects of an acyl-coenzyme A:cholesterol acyltransferase inhibitor on HDL-induced cholesterol efflux from rat macrophage foam cells.
FEBS letters 1995;363(1-2):29-32.
1995: T Ohta; R Nakamura; K Takata; Y Saito; S Yamashita; Seikoh Horiuchi; I Matsuda
Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency.
Journal of lipid research 1995;36(4):696-704.
1995: Akira Miyazaki; Masakazu Sakai; Hideki Hakamata; Seikoh Horiuchi
Multi-functional aspects of high density lipoprotein as an anti-atherogenic lipoprotein in vivo: evidence from in vitro experiments using macrophages.
Journal of atherosclerosis and thrombosis 1995;2(1):30-6.
1995: Seikoh Horiuchi; Toshihiro Higashi; Kyoji Ikeda; Tetsushi Saishoji; Yoshiteru Jinnouchi; H Sano; Norie Araki
Structures of advanced glycation end products and their role in pathophysiological states.
Contributions to nephrology 1995;112():32-41.
1994: Masakazu Sakai; Akira Miyazaki; Hideki Hakamata; T Sasaki; S Yui; M Yamazaki; Motoaki Shichiri; Seikoh Horiuchi
Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.
The Journal of biological chemistry 1994;269(50):31430-5.
1994: Hideki Hakamata; Akira Miyazaki; Masakazu Sakai; Y Suginohara; Y Sakamoto; Seikoh Horiuchi
Species difference in cholesteryl ester cycle and HDL-induced cholesterol efflux from macrophage foam cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(11):1860-5.
1994: T Mori; K Takahashi; M Naito; Tatsuhiko Kodama; Hideki Hakamata; Masakazu Sakai; Akira Miyazaki; Seikoh Horiuchi; M Ando
Endocytic pathway of scavenger receptors via trans-Golgi system in bovine alveolar macrophages.
Laboratory investigation; a journal of technical methods and pathology 1994;71(3):409-16.
1994: T Ohta; R Nakamura; Y Ikeda; J Frohlich; K Takata; Y Saito; Seikoh Horiuchi; I Matsuda
Evidence for impaired cellular cholesterol removal mediated by apo A-I containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency.
Biochimica et biophysica acta 1994;1213(3):295-301.
1994: T Ohta; S Hattori; R Nakamura; Seikoh Horiuchi; J Frohlich; K Takata; Y Ikeda; Y Saito; I Matsuda
Characterization of subspecies of apolipoprotein A-I-containing lipoprotein in homozygotes for familial lecithin:cholesterol acyltransferase deficiency.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(7):1137-45.
1994: Akira Miyazaki; Masakazu Sakai; Y Suginohara; Hideki Hakamata; Y Sakamoto; W Morikawa; Seikoh Horiuchi
Acetylated low density lipoprotein reduces its ligand activity for the scavenger receptor after interaction with reconstituted high density lipoprotein.
The Journal of biological chemistry 1994;269(7):5264-9.
1994: Seikoh Horiuchi; Norie Araki
Advanced glycation end products of the Maillard reaction and their relation to aging.
Gerontology 1994;40 Suppl 2():10-5.
1993: Akira Miyazaki; Masakazu Sakai; E Yamaguchi; Y Sakamoto; Motoaki Shichiri; Seikoh Horiuchi
Two independent macrophage receptors for acetylated high-density lipoprotein.
Biochimica et biophysica acta 1993;1170(2):143-50.
1993: N Adachi; K Takaki; R Nakamura; T Ohta; M Naito; Seikoh Horiuchi; I Matsuda
Establishment and characterization of a novel human monocytic leukemia cell line (KP-1) expressing scavenger receptor.
Pediatric research 1993;34(3):258-64.
1993: Akira Miyazaki; Seikoh Horiuchi
[Recent advances in lipoprotein metabolism].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(8):1954-60.
1993: K Suzaki; S Kobori; M Ide; Takayuki Sasahara; Masakazu Sakai; T Toyonaga; M Shinohara; Akira Miyazaki; Seikoh Horiuchi; H Takeda
Acetyl-low density lipoprotein receptors on rat mesangial cells.
Atherosclerosis 1993;101(2):177-84.
1992: Masakazu Sakai; Akira Miyazaki; Y Sakamoto; Motoaki Shichiri; Seikoh Horiuchi
Cross-linking of apolipoproteins is involved in a loss of the ligand activity of high density lipoprotein upon Cu(2+)-mediated oxidation.
FEBS letters 1992;314(2):199-202.
1992: T Ohta; R Nakamura; Y Ikeda; M Shinohara; Akira Miyazaki; Seikoh Horiuchi; I Matsuda
Differential effect of subspecies of lipoprotein containing apolipoprotein A-I on cholesterol efflux from cholesterol-loaded macrophages: functional correlation with lecithin: cholesterol acyltransferase.
Biochimica et biophysica acta 1992;1165(1):119-28.
1992: Akira Miyazaki; A T Rahim; T Ohta; Y Morino; Seikoh Horiuchi
High density lipoprotein mediates selective reduction in cholesteryl esters from macrophage foam cells.
Biochimica et biophysica acta 1992;1126(1):73-80.
1992: Norie Araki; N Ueno; B Chakrabarti; Y Morino; Seikoh Horiuchi
Immunochemical evidence for the presence of advanced glycation end products in human lens proteins and its positive correlation with aging.
The Journal of biological chemistry 1992;267(15):10211-4.
1992: M Shinohara; Akira Miyazaki; Motoaki Shichiri; Y Morino; Seikoh Horiuchi
Exposure of rat peritoneal macrophages to acetylated low density lipoprotein results in release of plasma membrane cholesterol. An efficient substrate for esterification by acyl-CoA:cholesterol acyltransferase.
The Journal of biological chemistry 1992;267(3):1603-8.
1991: S Ueno; S Kobori; M Ide; K Suzaki; H Takeda; Seikoh Horiuchi; Motoaki Shichiri
A specific binding site for lipoproteins containing apolipoprotein A-I on human hepatoma cell line HepG2.
Japanese journal of medicine 1991;30(6):524-33.
1991: Seikoh Horiuchi; Norie Araki; Y Morino
Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structure.
The Journal of biological chemistry 1991;266(12):7329-32.
1991: A T Rahim; Akira Miyazaki; Y Morino; Seikoh Horiuchi
Biochemical demonstration of endocytosis and subsequent resecretion of high-density lipoprotein by rat peritoneal macrophages.
Biochimica et biophysica acta 1991;1082(2):195-203.
1991: Akira Miyazaki; A T Rahim; S Araki; Y Morino; Seikoh Horiuchi
Chemical cross-linking alters high-density lipoprotein to be recognized by a scavenger receptor in rat peritoneal macrophages.
Biochimica et biophysica acta 1991;1082(2):143-51.
1990: Akira Miyazaki; Seikoh Horiuchi; S Araki
[Interaction of HDL with cells].
Nihon rinsho. Japanese journal of clinical medicine 1990;48(11):2506-12.
1990: M Murakami; Yukitaka Ushio; Y Mihara; Jun-ichi Kuratsu; Seikoh Horiuchi; Y Morino
Cholesterol uptake by human glioma cells via receptor-mediated endocytosis of low-density lipoprotein.
Journal of neurosurgery 1990;73(5):760-7.
1990: N Araki; Seikoh Horiuchi; A T Rahim; K Takata; Y Morino
Microquantification of cholesterol and cholesteryl esters in rat peritoneal macrophages by reverse-phase high-performance liquid chromatography.
Analytical biochemistry 1990;185(2):339-45.
1989: K Takata; Seikoh Horiuchi; Norie Araki; M Shiga; M Saitoh; Y Morino
Scavenger receptor of human monocytic leukemia cell line (THP-1) and murine macrophages for nonenzymatically glycosylated proteins.
Biochimica et biophysica acta 1989;986(1):18-26.
1989: T Ohta; K Takata; Seikoh Horiuchi; Y Morino; I Matsuda
Protective effect of lipoproteins containing apoprotein A-I on Cu2+-catalyzed oxidation of human low density lipoprotein.
FEBS letters 1989;257(2):435-8.
1989: K Takata; Seikoh Horiuchi; Y Morino
Scavenger receptor-mediated recognition of maleylated albumin and its relation to subsequent endocytic degradation.
Biochimica et biophysica acta 1989;984(3):273-80.
1989: Seikoh Horiuchi; K Takata; Norie Araki; Y Morino
Regional ligand domain is involved in scavenger receptor-mediated recognition of maleyl-albumin by rat sinusoidal liver cells.
Journal of molecular recognition : JMR 1989;2(2):56-62.
1989: Shozo Shoji; O Takenaka; Y Kida; M Matsunaga; M Hayashi; Seikoh Horiuchi; Y Kubota
A novel antibody against a synthetic NH2-terminal myristoyl glycyl src peptide can detect pp60v-src, the transforming protein of Rous sarcoma virus.
Molecular and cellular probes 1989;3(3):213-24.
1989: K Takahashi; S Fukuda; M Naito; Seikoh Horiuchi; K Takata; Y Morino
Endocytic pathway of high density lipoprotein via trans-Golgi system in rat resident peritoneal macrophages.
Laboratory investigation; a journal of technical methods and pathology 1989;61(3):270-7.
1989: Shozo Shoji; A Tashiro; K Furuishi; O Takenaka; Y Kida; Seikoh Horiuchi; T Funakoshi; Y Kubota
Antibodies to an NH2-terminal myristoyl glycine moiety can detect NH2-terminal myristoylated proteins in the retrovirus-infected cells.
Biochemical and biophysical research communications 1989;162(2):724-32.
1989: Y Haga; K Takata; N Araki; Kiyoshi Sakamoto; M Akagi; Y Morino; Seikoh Horiuchi
Intracellular accumulation of cholesteryl esters suppresses production of lipopolysaccharide-induced interleukin 1 by rat peritoneal macrophages.
Biochemical and biophysical research communications 1989;160(2):874-80.
1989: T Ohta; S Hattori; M Murakami; Seikoh Horiuchi; S Nishiyama; I Matsuda
Isolation of apolipoprotein A-I-containing lipoproteins by immunoaffinity chromatography using a formylated derivative of cellulose gel.
Clinica chimica acta; international journal of clinical chemistry 1989;179(2):183-90.
1988: Seikoh Horiuchi; M Shiga; Norie Araki; K Takata; M Saitoh; Y Morino
Evidence against in vivo presence of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole, a major fluorescent advanced end product generated by nonenzymatic glycosylation.
The Journal of biological chemistry 1988;263(35):18821-6.
1988: K Takata; Seikoh Horiuchi; Norie Araki; M Shiga; M Saitoh; Y Morino
Endocytic uptake of nonenzymatically glycosylated proteins is mediated by a scavenger receptor for aldehyde-modified proteins.
The Journal of biological chemistry 1988;263(29):14819-25.
1988: K Takata; Seikoh Horiuchi; A T Rahim; Y Morino
Receptor-mediated internalization of high density lipoprotein by rat sinusoidal liver cells: identification of a nonlysosomal endocytic pathway by fluorescence-labeled ligand.
Journal of lipid research 1988;29(9):1117-26.