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Curt Horvath

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
14
Parisien, Jean-Patrick
11
Darnell, James
8
Rodriguez, Jason
7
Lau, Joe
6
Nusinzon, Inna
5
Ulane, Christina
3
Stark, George
3
Lamb, Robert
3
Cruz, Cristian
3
Basler, Christopher
2
Bromberg, Jacqueline
2
García-Sastre, Adolfo
2
Kraus, Thomas
2
Kerr, Ian
2
Moran, Thomas

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Publications

TOP 3
Ramachandran Aparna; Horvath Curt M
Paramyxovirus disruption of interferon signal transduction: STATus report.
Parisien Jean-Patrick; Bamming Darja; Komuro Akihiko; Ramachandran Aparna; Rodriguez Jason J; Barber Glen; Wojahn Robert D; Horvath Curt M
A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.
Puri Mamta; Lemon Ken; Duprex W Paul; Rima Bertus K; Horvath Curt M
A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.

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All Publications

2009: Ramachandran Aparna; Horvath Curt M
Paramyxovirus disruption of interferon signal transduction: STATus report.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(9):531-7.
2009: Parisien Jean-Patrick; Bamming Darja; Komuro Akihiko; Ramachandran Aparna; Rodriguez Jason J; Barber Glen; Wojahn Robert D; Horvath Curt M
A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2.
Journal of virology 2009;83(14):7252-60.
2009: Puri Mamta; Lemon Ken; Duprex W Paul; Rima Bertus K; Horvath Curt M
A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.
Journal of virology 2009;83(13):6347-56.
2009: Bamming Darja; Horvath Curt M
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
The Journal of biological chemistry 2009;284(15):9700-12.
2008: Komuro Akihiko; Bamming Darja; Horvath Curt M
Negative regulation of cytoplasmic RNA-mediated antiviral signaling.
Cytokine 2008;43(3):350-8.
2008: Friedman Constantin S; O'Donnell Marie Anne; Legarda-Addison Diana; Ng Aylwin; Cárdenas Washington B; Yount Jacob S; Moran Thomas M; Basler Christopher F; Komuro Akihiko; Horvath Curt M; Xavier Ramnik; Ting Adrian T
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
EMBO reports 2008;9(9):930-6.
2008: Ramachandran Aparna; Parisien Jean-Patrick; Horvath Curt M
STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition.
Journal of virology 2008;82(17):8330-8.
2008: Ludlow Louise E; Lo Michael K; Rodriguez Jason J; Rota Paul A; Horvath Curt M
Henipavirus V protein association with Polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion.
Journal of virology 2008;82(13):6259-71.
2008: Lu Lenette L; Puri Mamta; Horvath Curt M; Sen Ganes C
Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.
The Journal of biological chemistry 2008;283(21):14269-76.
2008: Kraus Thomas A; Garza Lily; Horvath Curt M
Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection.
Virology 2008;371(1):196-205.
2006: Komuro Akihiko; Horvath Curt M
RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.
Journal of virology 2006;80(24):12332-42.
2006: Yount Jacob S; Kraus Thomas A; Horvath Curt M; Moran Thomas M; López Carolina B
A novel role for viral-defective interfering particles in enhancing dendritic cell maturation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4503-13.
2006: Cruz Cristian D; Palosaari Heidi; Parisien Jean-Patrick; Devaux Patricia; Cattaneo Roberto; Ouchi Toru; Horvath Curt M
Measles virus V protein inhibits p53 family member p73.
Journal of virology 2006;80(11):5644-50.
2006: Gu Wenxin; Nusinzon Inna; Smith Ronald D; Horvath Curt M; Silverman Richard B
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases.
Bioorganic & medicinal chemistry 2006;14(10):3320-9.
2006: Nusinzon Inna; Horvath Curt M
Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation.
Molecular and cellular biology 2006;26(8):3106-13.
2005: Nusinzon Inna; Horvath Curt M
Unexpected roles for deacetylation in interferon- and cytokine-induced transcription.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(12):745-8.
2005: Nusinzon Inna; Horvath Curt M
Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation.
Science's STKE : signal transduction knowledge environment 2005;2005(296):re11.
2005: Ulane Christina M; Kentsis Alex; Cruz Cristian D; Parisien Jean-Patrick; Schneider Kristi L; Horvath Curt M
Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain.
Journal of virology 2005;79(16):10180-9.
2004: Horvath Curt M
Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein.
European journal of biochemistry / FEBS 2004;271(23-24):4621-8.
2004: Horvath Curt M
The Jak-STAT pathway stimulated by interleukin 6.
Science's STKE : signal transduction knowledge environment 2004;2004(260):tr9.
2004: Horvath Curt M
The Jak-STAT pathway stimulated by interferon gamma.
Science's STKE : signal transduction knowledge environment 2004;2004(260):tr8.
2004: Horvath Curt M
The Jak-STAT pathway stimulated by interferon alpha or interferon beta.
Science's STKE : signal transduction knowledge environment 2004;2004(260):tr10.
2004: Rodriguez Jason J; Cruz Cristian D; Horvath Curt M
Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion.
Journal of virology 2004;78(10):5358-67.
2004: Horvath Curt M
Silencing STATs: lessons from paramyxovirus interferon evasion.
Cytokine & growth factor reviews 2004;15(2-3):117-27.
2004: Rodriguez Jason J; Horvath Curt M
Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling.
Viral immunology 2004;17(2):210-9.
2003: Nusinzon Inna; Horvath Curt M
Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14742-7.
2003: Rodriguez Jason J; Wang Lin-Fa; Horvath Curt M
Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.
Journal of virology 2003;77(21):11842-5.
2003: Zhu Chen; Rao Kavitha; Xiong Huabao; Gagnidze Khatuna; Li Fengling; Horvath Curt; Plevy Scott
Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP.
The Journal of biological chemistry 2003;278(41):39372-82.
2003: Rogers Richard S; Horvath Curt M; Matunis Michael J
SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.
The Journal of biological chemistry 2003;278(32):30091-7.
2003: Palosaari Heidi; Parisien Jean-Patrick; Rodriguez Jason J; Ulane Christina M; Horvath Curt M
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
Journal of virology 2003;77(13):7635-44.
2003: Ulane Christina M; Rodriguez Jason J; Parisien Jean-Patrick; Horvath Curt M
STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling.
Journal of virology 2003;77(11):6385-93.
2003: Kraus Thomas A; Lau Joe F; Parisien Jean-Patrick; Horvath Curt M
A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response.
The Journal of biological chemistry 2003;278(15):13033-8.
2003: Lau Joe F; Nusinzon Inna; Burakov Darya; Freedman Leonard P; Horvath Curt M
Role of metazoan mediator proteins in interferon-responsive transcription.
Molecular and cellular biology 2003;23(2):620-8.
2002: Ulane Christina M; Horvath Curt M
Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components.
Virology 2002;304(2):160-6.
2002: Rodriguez Jason J; Parisien Jean-Patrick; Horvath Curt M
Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.
Journal of virology 2002;76(22):11476-83.
2002: Parisien Jean-Patrick; Lau Joe F; Horvath Curt M
STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication.
Journal of virology 2002;76(13):6435-41.
2002: Aaronson David S; Horvath Curt M
A road map for those who don't know JAK-STAT.
Science (New York, N.Y.) 2002;296(5573):1653-5.
2002: Lau Joe F; Horvath Curt M
Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses.
The Mount Sinai journal of medicine, New York 2002;69(3):156-68.
2002: Parisien Jean-Patrick; Lau Joe F; Rodriguez Jason J; Ulane Christina M; Horvath Curt M
Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction.
Journal of virology 2002;76(9):4190-8.
2002: Salvatore Mirella; Basler Christopher F; Parisien Jean-Patrick; Horvath Curt M; Bourmakina Svetlana; Zheng Hongyong; Muster Thomas; Palese Peter; García-Sastre Adolfo
Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis.
Journal of virology 2002;76(3):1206-12.
2001: Myers M P; Andersen J N; Cheng A; Tremblay M L; Horvath C M; Parisien J P; Salmeen A; Barford D; Tonks N K
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.
The Journal of biological chemistry 2001;276(51):47771-4.
2001: Parisien J P; Lau J F; Rodriguez J J; Sullivan B M; Moscona A; Parks G D; Lamb R A; Horvath C M
The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2.
Virology 2001;283(2):230-9.
2001: Ivanov V N; Bhoumik A; Krasilnikov M; Raz R; Owen-Schaub L B; Levy D; Horvath C M; Ronai Z
Cooperation between STAT3 and c-jun suppresses Fas transcription.
Molecular cell 2001;7(3):517-28.
2001: Ehret G B; Reichenbach P; Schindler U; Horvath C M; Fritz S; Nabholz M; Bucher P
DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites.
The Journal of biological chemistry 2001;276(9):6675-88.
2000: Horvath C M
STAT proteins and transcriptional responses to extracellular signals.
Trends in biochemical sciences 2000;25(10):496-502.
2000: Talon J; Horvath C M; Polley R; Basler C F; Muster T; Palese P; García-Sastre A
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.
Journal of virology 2000;74(17):7989-96.
2000: Huang Y; Horvath C M; Waxman S
Regrowth of 5-fluorouracil-treated human colon cancer cells is prevented by the combination of interferon gamma, indomethacin, and phenylbutyrate.
Cancer research 2000;60(12):3200-6.
2000: Lau J F; Parisien J P; Horvath C M
Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7278-83.
2000: Ouchi T; Lee S W; Ouchi M; Aaronson S A; Horvath C M
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5208-13.
2000: Zong C S; Chan J; Levy D E; Horvath C; Sadowski H B; Wang L H
Mechanism of STAT3 activation by insulin-like growth factor I receptor.
The Journal of biological chemistry 2000;275(20):15099-105.
2000: Ram P T; Horvath C M; Iyengar R
Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein.
Science (New York, N.Y.) 2000;287(5450):142-4.
1999: Zhang X; Wrzeszczynska M H; Horvath C M; Darnell J E
Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation.
Molecular and cellular biology 1999;19(10):7138-46.
1998: Bromberg J F; Horvath C M; Besser D; Lathem W W; Darnell J E
Stat3 activation is required for cellular transformation by v-src.
Molecular and cellular biology 1998;18(5):2553-8.
1997: Kumar A; Commane M; Flickinger T W; Horvath C M; Stark G R
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases.
Science (New York, N.Y.) 1997;278(5343):1630-2.
1997: Ceresa B P; Horvath C M; Pessin J E
Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway.
Endocrinology 1997;138(10):4131-7.
1997: Horvath C M; Darnell J E
The state of the STATs: recent developments in the study of signal transduction to the nucleus.
Current opinion in cell biology 1997;9(2):233-9.
1996: Zhang J J; Vinkemeier U; Gu W; Chakravarti D; Horvath C M; Darnell J E
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15092-6.
1996: Horvath C M; Stark G R; Kerr I M; Darnell J E
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
Molecular and cellular biology 1996;16(12):6957-64.
1996: Vaisse C; Halaas J L; Horvath C M; Darnell J E; Stoffel M; Friedman J M
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Nature genetics 1996;14(1):95-7.
1996: Bromberg J F; Horvath C M; Wen Z; Schreiber R D; Darnell J E
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7673-8.
1996: Horvath C M; Darnell J E
The antiviral state induced by alpha interferon and gamma interferon requires transcriptionally active Stat1 protein.
Journal of virology 1996;70(1):647-50.
1995: Horvath C M; Wen Z; Darnell J E
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.
Genes & development 1995;9(8):984-94.
1994: Improta T; Schindler C; Horvath C M; Kerr I M; Stark G R; Darnell J E
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4776-80.
1994: Shuai K; Horvath C M; Huang L H; Qureshi S A; Cowburn D; Darnell J E
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Cell 1994;76(5):821-8.
1992: Horvath C M; Paterson R G; Shaughnessy M A; Wood R; Lamb R A
Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia.
Journal of virology 1992;66(7):4564-9.
1992: Horvath C M; Lamb R A
Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion.
Journal of virology 1992;66(4):2443-55.
1991: Lamb R A; Horvath C M
Diversity of coding strategies in influenza viruses.
Trends in genetics : TIG 1991;7(8):261-6.
1990: Horvath C M; Williams M A; Lamb R A
Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide.
The EMBO journal 1990;9(8):2639-47.

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