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Robert Horvitz

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Daniel P Denning; Victoria Hatch; H Robert Horvitz
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
Güliz Gürel; Megan A Gustafson; H Robert Horvitz; Judy S Pepper; Michael R Koelle
Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
Lesley Emtage; Christopher Fang-Yen; H Robert Horvitz; Olivia Padovan-Merhar; Sonya Aziz-Zaman; Niels Ringstad
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.

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2013: Daniel P Denning; Victoria Hatch; H Robert Horvitz
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
PLoS genetics 2013;9(3):e1003341.
2012: Güliz Gürel; Megan A Gustafson; H Robert Horvitz; Judy S Pepper; Michael R Koelle
Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
Genetics 2012;192(4):1359-71.
2012: Lesley Emtage; Christopher Fang-Yen; H Robert Horvitz; Olivia Padovan-Merhar; Sonya Aziz-Zaman; Niels Ringstad
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(46):16285-95.
2012: Daniel P Denning; Victoria Hatch; H Robert Horvitz
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
Nature 2012;488(7410):226-30.
2012: Konstantinos Boulias; H Robert Horvitz
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.
Cell metabolism 2012;15(4):439-50.
2012: Dengke K Ma; Roman Vozdek; Nikhil Bhatla; H Robert Horvitz
CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.
Neuron 2012;73(5):925-40.
2012: Courtney Anderson; H Robert Horvitz; Emma Sawin; Shan Zhou; Michael E Hurwitz
SLI-1 Cbl inhibits the engulfment of apoptotic cells in C. elegans through a ligase-independent function.
PLoS genetics 2012;8(12):e1003115.
2012: Long Ma; Yanling Teng; Xiaoyang Gao; Liange Huang; Jintao Luo; H Robert Horvitz
The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.
PLoS genetics 2012;8(7):e1002827.
2012: Daniel T Omura; Aravinthan D T Samuel; Damon A Clark; H Robert Horvitz
Dopamine signaling is essential for precise rates of locomotion by C. elegans.
PloS one 2012;7(6):e38649.
2011: Long Ma; Zhiping Tan; Yanling Teng; Sebastian Hoersch; H Robert Horvitz
In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans.
RNA (New York, N.Y.) 2011;17(12):2201-11.
2011: David T Harris; H Robert Horvitz
MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
Development (Cambridge, England) 2011;138(18):4051-62.
2011: Tomoko M Tabuchi; Bart Deplancke; Naoki Osato; Lihua J Zhu; M Inmaculada Barrasa; Melissa M Harrison; H Robert Horvitz; Albertha J M Walhout; Kirsten A Hagstrom
Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex.
PLoS genetics 2011;7(5):e1002074.
2011: Ewa M Davison; Adam M Saffer; Linda S Huang; JA DeModena; Paul W Sternberg; H Robert Horvitz
The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination.
Genetics 2011;187(3):803-15.
2011: Jerome Korzelius; Inge The; Suzan Ruijtenberg; Vincent Portegijs; Huihong Xu; H Robert Horvitz; Sander van den Heuvel
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.
Developmental biology 2011;350(2):358-69.
2011: Brendan D Galvin; Daniel P Denning; H Robert Horvitz
SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(5):1998-2003.
2011: Elissa A Hallem; W Clay Spencer; Rebecca D McWhirter; Georg Zeller; Stefan R Henz; Gunnar Rätsch; David M Miller; H Robert Horvitz; Paul W Sternberg; Niels Ringstad
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):254-9.
2010: Shunji Nakano; Ronald E Ellis; H Robert Horvitz
Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.
Development (Cambridge, England) 2010;137(23):4017-27.
2010: Alina Berdichevsky; Simona Nedelcu; Konstantinos Boulias; Nicholas A Bishop; Leonard Guarente; H Robert Horvitz
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18927-32.
2010: Takashi Hirose; Brendan D Galvin; H Robert Horvitz
Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15479-84.
2010: Ezequiel Alvarez-Saavedra; H Robert Horvitz
Many families of C. elegans microRNAs are not essential for development or viability.
Current biology : CB 2010;20(4):367-73.
2009: Maelle Jospin; Yingchuan B Qi; Tamara M Stawicki; Thomas Boulin; Kim R Schuske; H Robert Horvitz; Jean-Louis Bessereau; Erik M Jorgensen; Yishi Jin
A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.
PLoS biology 2009;7(12):e1000265.
2009: Long Ma; H Robert Horvitz
Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo.
PLoS genetics 2009;5(11):e1000708.
2009: Niels Ringstad; Namiko Abe; H Robert Horvitz
Ligand-gated chloride channels are receptors for biogenic amines in C. elegans.
Science (New York, N.Y.) 2009;325(5936):96-100.
2009: Michael E. Hurwitz; Pamela Vanderzalm; Laird Bloom; Julia Goldman; Gian Garriga; H Robert Horvitz
Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans.
PLoS biology 2009;7(4):e99.
2009: Pamela Vanderzalm; Amita Pandey; Michael E. Hurwitz; Laird Bloom; H Robert Horvitz; Gian Garriga
C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development.
Development (Cambridge, England) 2009;136(7):1201-10.
2009: Hui Yu; Adeline Seah; Michael A Herman; Edwin L Ferguson; H Robert Horvitz; Paul W Sternberg
Wnt and EGF pathways act together to induce C. elegans male hook development.
Developmental biology 2009;327(2):419-32.
2009: T J Kwiatkowski; D A Bosco; A L Leclerc; E Tamrazian; Charles R Vanderburg; C Russ; A Davis; J Gilchrist; E J Kasarskis; T Munsat; P Valdmanis; G A Rouleau; Betsy A Hosler; P Cortelli; P J de Jong; Y Yoshinaga; Jonathan L Haines; Margaret Pericak-Vance; J Yan; N Ticozzi; Teepu Siddique; Diane McKenna-Yasek; Peter C Sapp; H Robert Horvitz; J E Landers; Robert H Brown
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2009;323(5918):1205-8.
2009: Claire L Simpson; Robin Lemmens; Katarzyna Miskiewicz; Wendy J Broom; Valerie K Hansen; Paul W J van Vught; John E Landers; Peter Sapp; Ludo Van Den Bosch; Joanne Knight; Benjamin M Neale; Martin R Turner; Jan Veldink; Roel A Ophoff; Vineeta B Tripathi; Ana Beleza; Meera N Shah; Petroula Proitsi; Annelies Van Hoecke; Peter Carmeliet; H Robert Horvitz; P Nigel Leigh; Christopher Shaw; Leonard H van den Berg; Pak C Sham; John F Powell; Patrik Verstreken; Robert H Brown; Wim Robberecht; Ammar Al-Chalabi
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Human molecular genetics 2009;18(3):472-81.
2008: Niels Ringstad; H Robert Horvitz
FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans.
Nature neuroscience 2008;11(10):1168-76.
2008: Erik Andersen; Adam M Saffer; H Robert Horvitz
Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates.
Genetics 2008;179(4):2001-12.
2008: Brendan D Galvin; Saechin Kim; H Robert Horvitz
Caenorhabditis elegans genes required for the engulfment of apoptotic corpses function in the cytotoxic cell deaths induced by mutations in lin-24 and lin-33.
Genetics 2008;179(1):403-17.
2007: Eric A Miska; Ezequiel Alvarez-Saavedra; Allison L Abbott; Nelson C Lau; Andrew B Hellman; Shannon M McGonagle; David P Bartel; Victor R Ambros; H Robert Horvitz
Most Caenorhabditis elegans microRNAs are individually not essential for development or viability.
PLoS genetics 2007;3(12):e215.
2007: Hillel T Schwartz; H Robert Horvitz
The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.
Genes & development 2007;21(23):3181-94.
2007: Stefan Eimer; Alexander Gottschalk; Michael O. Hengartner; H Robert Horvitz; Janet E Richmond; William R Schafer; Jean-Louis Bessereau
Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.
The EMBO journal 2007;26(20):4313-23.
2007: Erik Andersen; H Robert Horvitz
Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
Development (Cambridge, England) 2007;134(16):2991-9.
2007: Melissa M. Harrison; Xiaowei Lu; H Robert Horvitz
LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.
Genetics 2007;176(1):255-71.
2007: Peter W. Reddien; Erik Andersen; Michael C Huang; H Robert Horvitz
DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.
Genetics 2007;175(4):1719-33.
2006: Melissa M. Harrison; Craig J Ceol; Xiaowei Lu; H Robert Horvitz
Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16782-7.
2006: Erik Andersen; Xiaowei Lu; H Robert Horvitz
C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.
Development (Cambridge, England) 2006;133(14):2695-704.
2006: Ala Berdichevsky; Mohan Viswanathan; H Robert Horvitz; Leonard Guarente
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
Cell 2006;125(6):1165-77.
2006: Craig J Ceol; Frank Stegmeier; Melissa M. Harrison; H Robert Horvitz
Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.
Genetics 2006;173(2):709-26.
2006: M Morita; Ammar Al-Chalabi; Peter M Andersen; Betsy A Hosler; Peter C Sapp; E Englund; J E Mitchell; James Habgood; Jackie de Belleroche; J Xi; W Jongjaroenprasert; H Robert Horvitz; L-G Gunnarsson; Robert H Brown
A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia.
Neurology 2006;66(6):839-44.
2006: Paresh R Shah; Azlina Ahmad-Annuar; Kourosh R Ahmadi; Carsten Russ; Peter C Sapp; H Robert Horvitz; Robert H Brown; David B Goldstein; Elizabeth M C Fisher
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2006;7(1):46-56.
2006: Cheng-Wen Su; Suzanne Tharin; Yishi Jin; Bruce Wightman; Mona Spector; David Meili; Nancy Tsung; Christa Rhiner; Dimitris Bourikas; Esther T Stoeckli; Gian Garriga; H Robert Horvitz; Michael O. Hengartner
The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans.
Journal of biology 2006;5(4):9.
2005: Ewa M Davison; Melissa M. Harrison; Albertha J M Walhout; Marc Vidal; H Robert Horvitz
lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein.
Genetics 2005;171(3):1017-31.
2005: Allison L Abbott; Ezequiel Alvarez-Saavedra; Eric A Miska; Nelson C Lau; David P Bartel; H Robert Horvitz; Victor Ambros
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.
Developmental cell 2005;9(3):403-14.
2005: C Andrew Frank; Nancy C Hawkins; Catherine Guenther; H Robert Horvitz; Gian Garriga
C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
Developmental biology 2005;284(2):301-10.
2005: Claudine Menard; H Robert Horvitz; Stephen Cannon
Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
The Journal of biological chemistry 2005;280(30):27502-7.
2005: Erno Wienholds; Wigard P Kloosterman; Eric A Miska; Ezequiel Alvarez-Saavedra; Eugene Berezikov; Ewart de Bruijn; H Robert Horvitz; Sakari Kauppinen; Ronald H Plasterk
MicroRNA expression in zebrafish embryonic development.
Science (New York, N.Y.) 2005;309(5732):310-1.
2005: Jun Lu; Gad Getz; Eric A Miska; Ezequiel Alvarez-Saavedra; Justin Lamb; David Peck; Eric A. Sweet-Cordero; Benjamin L Ebert; Raymond H Mak; Adolfo Ferrando; James R Downing; Tyler Jacks; H Robert Horvitz; Todd R Golub
MicroRNA expression profiles classify human cancers.
Nature 2005;435(7043):834-8.
2005: H Robert Horvitz
Obituary: Stanley J. Korsmeyer (1950-2005).
Nature 2005;435(7039):161.
2005: Mark J Alkema; Melissa Hunter-Ensor; Niels Ringstad; H Robert Horvitz
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.
Neuron 2005;46(2):247-60.
2004: Sibylle Jäger; Hillel T Schwartz; H Robert Horvitz; Barbara Conradt
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12549-54.
2004: Craig J Ceol; H Robert Horvitz
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.
Developmental cell 2004;6(4):563-76.
2004: Junying Yuan; H Robert Horvitz
A first insight into the molecular mechanisms of apoptosis.
Cell 2004;116(2 Suppl):S53-6, 1 p following S59.
2004: Peter W. Reddien; H Robert Horvitz
The engulfment process of programmed cell death in caenorhabditis elegans.
Annual review of cell and developmental biology 2004;20():193-221.
2004: Eric A Miska; Ezequiel Alvarez-Saavedra; Matthew Townsend; Akira Yoshii; Nenad Sestan; Pasko Rakic; Martha Constantine-Paton; H Robert Horvitz
Microarray analysis of microRNA expression in the developing mammalian brain.
Genome biology 2004;5(9):R68.
2003: Ignacio Perez de la Cruz; Joshua Z Levin; Claudia Cummins; Philip Anderson; H Robert Horvitz
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9133-45.
2003: H Robert Horvitz
Nobel lecture. Worms, life and death.
Bioscience reports 2003;23(5-6):239-303.
2003: H Robert Horvitz
Worms, life, and death (Nobel lecture).
Chembiochem : a European journal of chemical biology 2003;4(8):697-711.
2003: Peter C Sapp; Betsy A Hosler; Diane McKenna-Yasek; Wendy Chin; Amity Gann; Hilary Genise; Julie Gorenstein; Michael Huang; Wen Sailer; Meg Scheffler; Marianne Valesky; Jonathan L Haines; Margaret Pericak-Vance; Teepu Siddique; H Robert Horvitz; Robert H Brown
Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis.
American journal of human genetics 2003;73(2):397-403.
2003: Ho-Yon Hwang; Sara K Olson; Jeffrey D Esko; H Robert Horvitz
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.
Nature 2003;423(6938):439-43.
2003: Jeffrey Thomas; Craig J Ceol; Hillel T Schwartz; H Robert Horvitz
New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.
Genetics 2003;164(1):135-51.
2003: Ho-Yon Hwang; Sara K Olson; Jillian R Brown; Jeffrey D Esko; H Robert Horvitz
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase.
The Journal of biological chemistry 2003;278(14):11735-8.
2002: Ho-Yon Hwang; H Robert Horvitz
The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14224-9.
2002: Ho-Yon Hwang; H Robert Horvitz
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14218-23.
2002: Brad Michael Hersh; Erika Hartwieg; H Robert Horvitz
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4355-60.
2002: Scott Cameron; Scott G Clark; Joan B McDermott; Eric Aamodt; H Robert Horvitz
PAG-3, a Zn-finger transcription factor, determines neuroblast fate in C. elegans.
Development (Cambridge, England) 2002;129(7):1763-74.
2002: Yonatan B Tzur; Brad Michael Hersh; H Robert Horvitz; Yosef Gruenbaum
Fate of the nuclear lamina during Caenorhabditis elegans apoptosis.
Journal of structural biology 2002;137(1-2):146-53.
2001: Daniel A Starr; Greg J Hermann; Christian Malone; W Fixsen; James R Priess; H Robert Horvitz; Min Han
unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration.
Development (Cambridge, England) 2001;128(24):5039-50.
2001: Erik A Lundquist; Peter W. Reddien; Erika Hartwieg; H Robert Horvitz; Cornelia I Bargmann
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis.
Development (Cambridge, England) 2001;128(22):4475-88.
2001: Z Zhou; E Caron; Erika Hartwieg; Alan Hall; H Robert Horvitz
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.
Developmental cell 2001;1(4):477-89.
2001: Rama Ranganathan; ER Sawin; C Trent; H Robert Horvitz
Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(16):5871-84.
2001: Peter W. Reddien; Scott Cameron; H Robert Horvitz
Phagocytosis promotes programmed cell death in C. elegans.
Nature 2001;412(6843):198-202.
2001: Patricia M Berninsone; H Y Hwang; I Zemtseva; H Robert Horvitz; Carlos B Hirschberg
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3738-43.
2001: Craig J Ceol; H Robert Horvitz
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development.
Molecular cell 2001;7(3):461-73.
2001: Z Zhou; Erika Hartwieg; H Robert Horvitz
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.
Cell 2001;104(1):43-56.
2000: Rama Ranganathan; S C Cannon; H Robert Horvitz
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.
Nature 2000;408(6811):470-5.
2000: Betsy A Hosler; Teepu Siddique; Peter C Sapp; W Sailor; M C Huang; A Hossain; J R Daube; M Nance; C Fan; Joshua M Kaplan; Wu-Yen Hung; Diane McKenna-Yasek; Jonathan L Haines; Margaret Pericak-Vance; H Robert Horvitz; Robert H Brown
Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22.
JAMA : the journal of the American Medical Association 2000;284(13):1664-9.
2000: G J Beitel; E J Lambie; H Robert Horvitz
The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein.
Gene 2000;254(1-2):253-63.
2000: T W Harris; Erika Hartwieg; H Robert Horvitz; Erik M Jorgensen
Mutations in synaptojanin disrupt synaptic vesicle recycling.
The Journal of cell biology 2000;150(3):589-600.
2000: E K Speliotes; A Uren; D Vaux; H Robert Horvitz
The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.
Molecular cell 2000;6(2):211-23.
2000: ER Sawin; Rama Ranganathan; H Robert Horvitz
C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.
Neuron 2000;26(3):619-31.
2000: FJ Slack; Michael Basson; Z Liu; Victor Ambros; H Robert Horvitz; Gary Ruvkun
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
Molecular cell 2000;5(4):659-69.
2000: Gillian M. Stanfield; H Robert Horvitz
The ced-8 gene controls the timing of programmed cell deaths in C. elegans.
Molecular cell 2000;5(3):423-33.
2000: Y C Wu; Gillian M. Stanfield; H Robert Horvitz
NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis.
Genes & development 2000;14(5):536-48.
2000: Peter W. Reddien; H Robert Horvitz
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans.
Nature cell biology 2000;2(3):131-6.
2000: F Chen; Brad Michael Hersh; Barbara Conradt; Z Zhou; D Riemer; Yosef Gruenbaum; H Robert Horvitz
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.
Science (New York, N.Y.) 2000;287(5457):1485-9.
2000: Brenda J Reinhart; FJ Slack; Michael Basson; Amy E Pasquinelli; JC Bettinger; Ann E Rougvie; H Robert Horvitz; Gary Ruvkun
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
Nature 2000;403(6772):901-6.
2000: MA Lorson; H Robert Horvitz; Sander van den Heuvel
LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans.
The Journal of cell biology 2000;148(1):73-86.
1999: S Shaham; Peter W. Reddien; B Davies; H Robert Horvitz
Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.
Genetics 1999;153(4):1655-71.
1999: Anna P. Newman; G Z Acton; Erika Hartwieg; H Robert Horvitz; Paul W Sternberg
The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells.
Development (Cambridge, England) 1999;126(23):5319-26.
1999: Mark M Metzstein; H Robert Horvitz
The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein.
Molecular cell 1999;4(3):309-19.
1999: Barbara Conradt; H Robert Horvitz
The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene.
Cell 1999;98(3):317-27.
1999: C Eastman; H Robert Horvitz; Yishi Jin
Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(15):6225-34.
1999: Jeffrey Thomas; H Robert Horvitz
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.
Development (Cambridge, England) 1999;126(15):3449-59.
1999: Christian Malone; W D Fixsen; H Robert Horvitz; Min Han
UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.
Development (Cambridge, England) 1999;126(14):3171-81.
1999: H Robert Horvitz
Genetic control of programmed cell death in the nematode Caenorhabditis elegans.
Cancer research 1999;59(7 Suppl):1701s-1706s.
1999: T Herman; H Robert Horvitz
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):974-9.
1999: T Herman; Erika Hartwieg; H Robert Horvitz
sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):968-73.
1999: Tina Gumienny; E Lambie; Erika Hartwieg; H Robert Horvitz; Michael O. Hengartner
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
Development (Cambridge, England) 1999;126(5):1011-22.
1999: Yishi Jin; Erik M Jorgensen; Erika Hartwieg; H Robert Horvitz
The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):539-48.
1999: R Y Lee; ER Sawin; Martin Chalfie; H Robert Horvitz; Leon Avery
EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):159-67.
1998: Xiaowei Lu; H Robert Horvitz
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Cell 1998;95(7):981-91.
1998: Betsy A Hosler; Peter C Sapp; R Berger; Gilmore O'Neill; Khemissa Bejaoui; MB Hamida; Faycal Hentati; Wendy Chin; Diane McKenna-Yasek; Jonathan L Haines; D Patterson; H Robert Horvitz; Robert H Brown; C B Day
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33.
Neurogenetics 1998;2(1):34-42.
1998: Mark M Metzstein; Gillian M. Stanfield; H Robert Horvitz
Genetics of programmed cell death in C. elegans: past, present and future.
Trends in genetics : TIG 1998;14(10):410-6.
1998: D Jacobs; G J Beitel; S G Clark; H Robert Horvitz; Kerry Kornfeld
Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase.
Genetics 1998;149(4):1809-22.
1998: Y C Wu; H Robert Horvitz
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
Cell 1998;93(6):951-60.
1998: Barbara Conradt; H Robert Horvitz
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9.
Cell 1998;93(4):519-29.
1998: M Kokel; CZ Borland; L DeLong; H Robert Horvitz; Michael J Stern
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.
Genes & development 1998;12(10):1425-37.
1998: F Gonzales-Rosales; D Walsh; L Burkons; J Burkons; H Robert Horvitz
Chronic bleeding secondary to an unresectable duodenal adenocarcinoma controlled with sucralfate and famotidine.
Palliative medicine 1998;12(3):205-6.
1998: M Aoki; Chien-liang Glenn Lin; Jeffrey rothstein; B A Geller; Betsy A Hosler; T L Munsat; H Robert Horvitz; Robert H Brown
Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis.
Annals of neurology 1998;43(5):645-53.
1998: Y C Wu; H Robert Horvitz
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180.
Nature 1998;392(6675):501-4.
1997: F E Tax; James H Thomas; E L Ferguson; H Robert Horvitz
Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans.
Genetics 1997;147(4):1675-95.
1997: M Barkett; D Xue; H Robert Horvitz; Thomas D Gilmore
Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro.
The Journal of biological chemistry 1997;272(47):29419-22.
1997: D Xue; H Robert Horvitz
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor.
Nature 1997;390(6657):305-8.
1997: Michael L Nonet; J E Staunton; Michael Kilgard; T Fergestad; Erika Hartwieg; H Robert Horvitz; Erik M Jorgensen; Barbara J Meyer
Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(21):8061-73.
1997: R Y Lee; L Lobel; Michael O. Hengartner; H Robert Horvitz; Leon Avery
Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans.
The EMBO journal 1997;16(20):6066-76.
1997: L Bloom; H Robert Horvitz
The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3414-9.
1997: Merit E Cudkowicz; Diane McKenna-Yasek; P E Sapp; Wendy Chin; B Geller; D L Hayden; David Schoenfeld; Betsy A Hosler; H Robert Horvitz; Robert H Brown
Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis.
Annals of neurology 1997;41(2):210-21.
1997: T Herman; H Robert Horvitz
Mutations that perturb vulval invagination in C. elegans.
Cold Spring Harbor symposia on quantitative biology 1997;62():353-9.
1996: H Sawa; L Lobel; H Robert Horvitz
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
Genes & development 1996;10(17):2189-97.
1996: Michel Labouesse; E Hartwieg; H Robert Horvitz
The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates.
Development (Cambridge, England) 1996;122(9):2579-88.
1996: Mark M Metzstein; Michael O. Hengartner; N Tsung; Ronald E. Ellis; H Robert Horvitz
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.
Nature 1996;382(6591):545-7.
1996: M Basson; H Robert Horvitz
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
Genes & development 1996;10(15):1953-65.
1996: S Shaham; H Robert Horvitz
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.
Cell 1996;86(2):201-8.
1996: Tom Barnes; Y Jin; H Robert Horvitz; G Ruvkun; Siegfried Hekimi
The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein.
Journal of neurochemistry 1996;67(1):46-57.
1996: D Xue; S Shaham; H Robert Horvitz
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
Genes & development 1996;10(9):1073-83.
1996: S Shaham; H Robert Horvitz
Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.
Genes & development 1996;10(5):578-91.
1996: M R Koelle; H Robert Horvitz
EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
Cell 1996;84(1):115-25.
1995: G J Beitel; Simon Tuck; Iva Greenwald; H Robert Horvitz
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
Genes & development 1995;9(24):3149-62.
1995: K Kornfeld; D B Hom; H Robert Horvitz
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.
Cell 1995;83(6):903-13.
1995: D L DeVore; H Robert Horvitz; Michael J Stern
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites.
Cell 1995;83(4):611-20.
1995: Erik M Jorgensen; Erika Hartwieg; K Schuske; Michael L Nonet; Yishi Jin; H Robert Horvitz
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.
Nature 1995;378(6553):196-9.
1995: M A Herman; L L Vassilieva; H Robert Horvitz; Jocelyn E Shaw; Robert K Herman
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously.
Cell 1995;83(1):101-10.
1995: D Xue; H Robert Horvitz
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein.
Nature 1995;377(6546):248-51.
1995: A D Chisholm; H Robert Horvitz
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3.
Nature 1995;377(6544):52-5.
1995: P C Sapp; D R Rosen; Betsy A Hosler; J Esteban; Diane McKenna-Yasek; J P O'Regan; H Robert Horvitz; R H Brown
Identification of three novel mutations in the gene for Cu/Zn superoxide dismutase in patients with familial amyotrophic lateral sclerosis.
Neuromuscular disorders : NMD 1995;5(5):353-7.
1995: A C Bowling; E E Barkowski; Diane McKenna-Yasek; P Sapp; H Robert Horvitz; M Flint Beal; R H Brown
Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis.
Journal of neurochemistry 1995;64(5):2366-9.
1995: K Kornfeld; K L Guan; H Robert Horvitz
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
Genes & development 1995;9(6):756-68.
1994: Y Jin; R Hoskins; H Robert Horvitz
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein.
Nature 1994;372(6508):780-3.
1994: P Gregor; S M Gaston; X Yang; J P O'Regan; D R Rosen; Rudolph E Tanzi; D Patterson; Jonathan L Haines; H Robert Horvitz; George R. Uhl
Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.
Human genetics 1994;94(5):565-70.
1994: Michel Labouesse; Satis Sookhareea; H Robert Horvitz
The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor.
Development (Cambridge, England) 1994;120(9):2359-68.
1994: Michael O. Hengartner; H Robert Horvitz
The ins and outs of programmed cell death during C. elegans development.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;345(1313):243-6.
1994: S G Clark; X Lu; H Robert Horvitz
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
Genetics 1994;137(4):987-97.
1994: Michael O. Hengartner; H Robert Horvitz
Programmed cell death in Caenorhabditis elegans.
Current opinion in genetics & development 1994;4(4):581-6.
1994: J Esteban; D R Rosen; A C Bowling; P Sapp; Diane McKenna-Yasek; J P O'Regan; M Flint Beal; H Robert Horvitz; R H Brown
Identification of two novel mutations and a new polymorphism in the gene for Cu/Zn superoxide dismutase in patients with amyotrophic lateral sclerosis.
Human molecular genetics 1994;3(6):997-8.
1994: Michael O. Hengartner; H Robert Horvitz
Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved in Bcl-2.
Nature 1994;369(6478):318-20.
1994: D R Rosen; P Sapp; J O'Regan; Diane McKenna-Yasek; K S Schlumpf; Jonathan L Haines; James Gusella; H Robert Horvitz; R H Brown
Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers.
American journal of medical genetics 1994;51(1):61-9.
1994: M A Herman; H Robert Horvitz
The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.
Development (Cambridge, England) 1994;120(5):1035-47.
1994: Michael O. Hengartner; H Robert Horvitz
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
Cell 1994;76(4):665-76.
1994: M R Lackner; K Kornfeld; L M Miller; H Robert Horvitz; Stuart K Kim
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
Genes & development 1994;8(2):160-73.
1994: H Robert Horvitz; S Shaham; Michael O. Hengartner
The genetics of programmed cell death in the nematode Caenorhabditis elegans.
Cold Spring Harbor symposia on quantitative biology 1994;59():377-85.
1993: Junying Yuan; S Shaham; S Ledoux; H M Ellis; H Robert Horvitz
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.
Cell 1993;75(4):641-52.
1993: Gian Garriga; C Guenther; H Robert Horvitz
Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.
Genes & development 1993;7(11):2097-109.
1993: J Z Levin; H Robert Horvitz
Three new classes of mutations in the Caenorhabditis elegans muscle gene sup-9.
Genetics 1993;135(1):53-70.
1993: Cornelia I Bargmann; E Hartwieg; H Robert Horvitz
Odorant-selective genes and neurons mediate olfaction in C. elegans.
Cell 1993;74(3):515-27.
1993: S L McIntire; Erik M Jorgensen; Joshua M Kaplan; H Robert Horvitz
The GABAergic nervous system of Caenorhabditis elegans.
Nature 1993;364(6435):337-41.
1993: S L McIntire; Erik M Jorgensen; H Robert Horvitz
Genes required for GABA function in Caenorhabditis elegans.
Nature 1993;364(6435):334-7.
1993: S G Clark; A D Chisholm; H Robert Horvitz
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
Cell 1993;74(1):43-55.
1993: L Avery; C I Bargmann; H Robert Horvitz
The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions.
Genetics 1993;134(2):455-64.
1993: Joshua M Kaplan; H Robert Horvitz
A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2227-31.
1993: G Garriga; CJ Desai; H Robert Horvitz
Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans.
Development (Cambridge, England) 1993;117(3):1071-87.
1992: D H Donaldson; D R Rosen; J O'Regan; P C Sapp; H Robert Horvitz; James Gusella; Jonathan L Haines; S Pestka; V Jung; C Nusbaum
Two independent dinucleotide repeat polymorphisms at the D21S235 locus (21q22.1).
Human molecular genetics 1992;1(8):651.
1992: D R Rosen; P C Sapp; J O'Regan; H Robert Horvitz; D H Donaldson; C Nussbaum; James Gusella; Jonathan L Haines; S Pestka; V Jung
Dinucleotide repeat polymorphisms (D21S223 and D21S224) at 21q22.1.
Human molecular genetics 1992;1(7):547.
1992: Junying Yuan; H Robert Horvitz
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.
Development (Cambridge, England) 1992;116(2):309-20.
1992: Michael O. Hengartner; Ronald E. Ellis; H Robert Horvitz
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death.
Nature 1992;356(6369):494-9.
1992: J Z Levin; H Robert Horvitz
The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction.
The Journal of cell biology 1992;117(1):143-55.
1992: S G Clark; M J Stern; H Robert Horvitz
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Nature 1992;356(6367):340-4.
1992: S L McIntire; G Garriga; J White; D Jacobson; H Robert Horvitz
Genes necessary for directed axonal elongation or fasciculation in C. elegans.
Neuron 1992;8(2):307-22.
1992: H Robert Horvitz; Ira Herskowitz
Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question.
Cell 1992;68(2):237-55.
1992: S G Clark; M J Stern; H Robert Horvitz
Genes involved in two Caenorhabditis elegans cell-signaling pathways.
Cold Spring Harbor symposia on quantitative biology 1992;57():363-73.
1991: M J Stern; H Robert Horvitz
A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants.
Development (Cambridge, England) 1991;113(3):797-803.
1991: Paul W Sternberg; H Robert Horvitz
Signal transduction during C. elegans vulval induction.
Trends in genetics : TIG 1991;7(11-12):366-71.
1991: Cornelia I Bargmann; H Robert Horvitz
Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans.
Neuron 1991;7(5):729-42.
1991: P M Li; J Reichert; G Freyd; H Robert Horvitz; Christopher T Walsh
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):9210-3.
1991: Ronald E. Ellis; D M Jacobson; H Robert Horvitz
Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
Genetics 1991;129(1):79-94.
1991: H Robert Horvitz; P W Sternberg
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.
Nature 1991;351(6327):535-41.
1991: Ronald E. Ellis; H Robert Horvitz
Two C. elegans genes control the programmed deaths of specific cells in the pharynx.
Development (Cambridge, England) 1991;112(2):591-603.
1991: J Y Yuan; M Finney; N Tsung; H Robert Horvitz
Tc4, a Caenorhabditis elegans transposable element with an unusual fold-back structure.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3334-8.
1991: Cornelia I Bargmann; H Robert Horvitz
Control of larval development by chemosensory neurons in Caenorhabditis elegans.
Science (New York, N.Y.) 1991;251(4998):1243-6.
1991: R H Brown; H Robert Horvitz; G A Rouleau; Diane McKenna-Yasek; C Beard; P Sapp; Jonathan L Haines; James Gusella; Denise A Figlewicz
Gene linkage in familial amyotrophic lateral sclerosis: a progress report.
Advances in neurology 1991;56():215-26.
1991: Ronald E. Ellis; J Y Yuan; H Robert Horvitz
Mechanisms and functions of cell death.
Annual review of cell biology 1991;7():663-98.
1990: G J Beitel; S G Clark; H Robert Horvitz
Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction.
Nature 1990;348(6301):503-9.
1990: H Robert Horvitz; John E Sulston
"Joy of the worm".
Genetics 1990;126(2):287-92.
1990: J H Thomas; M J Stern; H Robert Horvitz
Cell interactions coordinate the development of the C. elegans egg-laying system.
Cell 1990;62(6):1041-52.
1990: G Freyd; S K Kim; H Robert Horvitz
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.
Nature 1990;344(6269):876-9.
1990: J Y Yuan; H Robert Horvitz
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death.
Developmental biology 1990;138(1):33-41.
1990: L Avery; H Robert Horvitz
Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.
The Journal of experimental zoology 1990;253(3):263-70.
1990: S K Kim; H Robert Horvitz
The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.
Genes & development 1990;4(3):357-71.
1990: Gary Ruvkun; Walter Gilbert; H Robert Horvitz
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.
Nucleic acids research 1990;18(4):809-15.
1990: Cornelia I Bargmann; J H Thomas; H Robert Horvitz
Chemosensory cell function in the behavior and development of Caenorhabditis elegans.
Cold Spring Harbor symposia on quantitative biology 1990;55():529-38.
1989: L Avery; H Robert Horvitz
Pharyngeal pumping continues after laser killing of the pharyngeal nervous system of C. elegans.
Neuron 1989;3(4):473-85.
1989: E L Ferguson; H Robert Horvitz
The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.
Genetics 1989;123(1):109-21.
1989: Paul W Sternberg; H Robert Horvitz
The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans.
Cell 1989;58(4):679-93.
1989: C Desai; H Robert Horvitz
Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.
Genetics 1989;121(4):703-21.
1989: Gary Ruvkun; V Ambros; A Coulson; Robert H Waterston; John E Sulston; H Robert Horvitz
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
Genetics 1989;121(3):501-16.
1988: CJ Desai; G Garriga; S L McIntire; H Robert Horvitz
A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons.
Nature 1988;336(6200):638-46.
1988: M Finney; Gary Ruvkun; H Robert Horvitz
The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
Cell 1988;55(5):757-69.
1988: Paul W Sternberg; H Robert Horvitz
lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions.
Developmental biology 1988;130(1):67-73.
1988: C Trent; William B Wood; H Robert Horvitz
A novel dominant transformer allele of the sex-determining gene her-1 of Caenorhabditis elegans.
Genetics 1988;120(1):145-57.
1988: H Robert Horvitz
Genetic control of Caenorhabditis elegans cell lineage.
Harvey lectures 1988;84():65-77.
1987: L Avery; H Robert Horvitz
A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant.
Cell 1987;51(6):1071-8.
1987: V Ambros; H Robert Horvitz
The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events.
Genes & development 1987;1(4):398-414.
1987: E L Ferguson; P W Sternberg; H Robert Horvitz
A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.
Nature 1987;326(6110):259-67.
1986: E C Park; H Robert Horvitz
C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.
Genetics 1986;113(4):853-67.
1986: E C Park; H Robert Horvitz
Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.
Genetics 1986;113(4):821-52.
1986: I Greenwald; H Robert Horvitz
A visible allele of the muscle gene sup-10X of C. elegans.
Genetics 1986;113(1):63-72.
1986: H M Ellis; H Robert Horvitz
Genetic control of programmed cell death in the nematode C. elegans.
Cell 1986;44(6):817-29.
1986: P W Sternberg; H Robert Horvitz
Pattern formation during vulval development in C. elegans.
Cell 1986;44(5):761-72.
1985: E L Ferguson; H Robert Horvitz
Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans.
Genetics 1985;110(1):17-72.
1984: V Ambros; H Robert Horvitz
Heterochronic mutants of the nematode Caenorhabditis elegans.
Science (New York, N.Y.) 1984;226(4673):409-16.
1984: P W Sternberg; H Robert Horvitz
The genetic control of cell lineage during nematode development.
Annual review of genetics 1984;18():489-524.
1983: I S Greenwald; P W Sternberg; H Robert Horvitz
The lin-12 locus specifies cell fates in Caenorhabditis elegans.
Cell 1983;34(2):435-44.
1983: C Trent; N Tsuing; H Robert Horvitz
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
Genetics 1983;104(4):619-47.
1983: H Robert Horvitz; P W Sternberg; I S Greenwald; W Fixsen; H M Ellis
Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans.
Cold Spring Harbor symposia on quantitative biology 1983;48 Pt 2():453-63.
1982: P W Sternberg; H Robert Horvitz
Postembryonic nongonadal cell lineages of the nematode Panagrellus redivivus: description and comparison with those of Caenorhabditis elegans.
Developmental biology 1982;93(1):181-205.
1982: J G White; H Robert Horvitz; John E Sulston
Neurone differentiation in cell lineage mutants of Caenorhabditis elegans.
Nature 1982;297(5867):584-7.
1982: I S Greenwald; H Robert Horvitz
Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans.
Genetics 1982;101(2):211-25.
1982: H Robert Horvitz; Martin Chalfie; C Trent; John E Sulston; P D Evans
Serotonin and octopamine in the nematode Caenorhabditis elegans.
Science (New York, N.Y.) 1982;216(4549):1012-4.
1981: P W Sternberg; H Robert Horvitz
Gonadal cell lineages of the nematode Panagrellus redivivus and implications for evolution by the modification of cell lineage.
Developmental biology 1981;88(1):147-66.
1981: Martin Chalfie; H Robert Horvitz; John E Sulston
Mutations that lead to reiterations in the cell lineages of C. elegans.
Cell 1981;24(1):59-69.
1981: John E Sulston; H Robert Horvitz
Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans.
Developmental biology 1981;82(1):41-55.
1980: H Robert Horvitz; John E Sulston
Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans.
Genetics 1980;96(2):435-54.
1980: I S Greenwald; H Robert Horvitz
unc-93(e1500): A behavioral mutant of Caenorhabditis elegans that defines a gene with a wild-type null phenotype.
Genetics 1980;96(1):147-64.
1979: H Robert Horvitz; Sydney Brenner; J Hodgkin; R K Herman
A uniform genetic nomenclature for the nematode Caenorhabditis elegans.
Molecular & general genetics : MGG 1979;175(2):129-33.
1977: John E Sulston; H Robert Horvitz
Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.
Developmental biology 1977;56(1):110-56.
1975: H Robert Horvitz
Studies of mutations in T4 control genes 33 and 55.
Genetics 1975;79(3):349-60.
1974: H Robert Horvitz
Bacteriophage T4 mutants deficient in alteration and modification of the Escherichia coli RNA polymerase.
Journal of molecular biology 1974;90(4):739-50.
1974: H Robert Horvitz
Control by bacteriophage T4 of two sequential phosphorylations of the alpha subunit of Escherichia coli RNA polymerase.
Journal of molecular biology 1974;90(4):727-38.
1973: H Robert Horvitz
Polypeptide bound to the host RNA polymerase is specified by T4 control gene 33.
Nature: New biology 1973;244(135):137-40.