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Joseph Horwitz

Research Profile

Chemicals & Drugs

Anatomy

Crystalline Lens

Disorders

Living Beings

Cattle

Phenomena

Concepts & Ideas

Procedures

Electrophoresis, Polyacrylamide Gel

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Phillip Wages; Rebecca W Corbin; Linlin Ding; Joseph Horwitz; Mason Posner
Changes in zebrafish (Danio rerio) lens crystallin content during development.
Arthur Laganowsky; Justin L P Benesch; Meytal Landau; Linlin Ding; Michael R Sawaya; Duilio Cascio; Qingling Huang; Carol V Robinson; Joseph Horwitz; David Eisenberg
Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function.
Qingling Huang; Linlin Ding; Kim B Phan; Catherine Cheng; Chun-hong Xia; Xiaohua Gong; Joseph Horwitz
Mechanism of cataract formation in alphaA-crystallin Y118D mutation.

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All Publications

2013: Phillip Wages; Rebecca W Corbin; Linlin Ding; Joseph Horwitz; Mason Posner
Changes in zebrafish (Danio rerio) lens crystallin content during development.
Molecular vision 2013;19():408-17.
2010: Arthur Laganowsky; Justin L P Benesch; Meytal Landau; Linlin Ding; Michael R Sawaya; Duilio Cascio; Qingling Huang; Carol V Robinson; Joseph Horwitz; David Eisenberg
Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function.
Protein science : a publication of the Protein Society 2010;19(5):1031-43.
2009: Qingling Huang; Linlin Ding; Kim B Phan; Catherine Cheng; Chun-hong Xia; Xiaohua Gong; Joseph Horwitz
Mechanism of cataract formation in alphaA-crystallin Y118D mutation.
Investigative ophthalmology & visual science 2009;50(6):2919-26.
2009: Joseph Horwitz
Alpha crystallin: the quest for a homogeneous quaternary structure.
Experimental eye research 2009;88(2):190-4.
2008: Ling Chen; Gary N Holland; Fei Yu; Ralph D Levinson; Kirsten J Lampi; Joseph Horwitz; Lynn K Gordon
Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis.
Investigative ophthalmology & visual science 2008;49(10):4476-81.
2007: Heath Ecroyd; Sarah Meehan; Joseph Horwitz; J Andrew Aquilina; Justin L P Benesch; Carol V Robinson; Cait E MacPhee; John A Carver
Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity.
The Biochemical journal 2007;401(1):129-41.
2006: Joseph Horwitz; Linlin Ding; Vasilis Vasiliou; Miriam Cantore; Joram Piatigorsky
Scallop lens Omega-crystallin (ALDH1A9): a novel tetrameric aldehyde dehydrogenase.
Biochemical and biophysical research communications 2006;348(4):1302-9.
2006: Eric Turk; Oktay Gasymov; Seren Lanza; Joseph Horwitz; Ernest M Wright
A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter.
Biochemistry 2006;45(5):1470-9.
2005: J Andrew Aquilina; Justin L P Benesch; Lin Lin Ding; Orna Yaron; Joseph Horwitz; Carol V Robinson
Subunit exchange of polydisperse proteins: mass spectrometry reveals consequences of alphaA-crystallin truncation.
The Journal of biological chemistry 2005;280(15):14485-91.
2005: Teresa M Treweek; Agata Rekas; Robyn A Lindner; Mark J Walker; J Andrew Aquilina; Carol V Robinson; Joseph Horwitz; Ming Der Perng; Roy A Quinlan; John A Carver
R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable.
The FEBS journal 2005;272(3):711-24.
2005: Jason M Dahlman; Kelli L Margot; Linlin Ding; Joseph Horwitz; Mason Posner
Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs.
Molecular vision 2005;11():88-96.
2004: John Hawse; J Fielding Hejtmancik; Joseph Horwitz; Marc Kantorow
Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.
Experimental eye research 2004;79(6):935-40.
2004: Joseph Horwitz; Qingling Huang; Linlin Ding
The native oligomeric organization of alpha-crystallin, is it necessary for its chaperone function?
Experimental eye research 2004;79(6):817-21.
2004: J Andrew Aquilina; Justin L P Benesch; Lin Lin Ding; Orna Yaron; Joseph Horwitz; Carol V Robinson
Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure.
The Journal of biological chemistry 2004;279(27):28675-80.
2004: Wendy Goodson; Lin Lin Ding; Qing Ling Huang; Jennifer R Kimbell; Joseph Horwitz; Margaret J McFall-Ngai
Reflectins: the unusual proteins of squid reflective tissues.
Science (New York, N.Y.) 2004;303(5655):235-8.
2004: Nathan L Mata; Walid N Moghrabi; Jung S Lee; Tam V Bui; Roxana A Radu; Joseph Horwitz; Gabriel H Travis
Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells.
The Journal of biological chemistry 2004;279(1):635-43.
2003: John Hawse; J Fielding Hejtmancik; Quingling Huang; Nancy L Sheets; Douglas A Hosack; Richard A Lempicki; Joseph Horwitz; Marc Kantorow
Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.
Molecular vision 2003;9():515-37.
2003: Joseph Horwitz
Alpha-crystallin.
Experimental eye research 2003;76(2):145-53.
2002: Michael P Bova; Qingling Huang; Linlin Ding; Joseph Horwitz
Subunit exchange, conformational stability, and chaperone-like function of the small heat shock protein 16.5 from Methanococcus jannaschii.
The Journal of biological chemistry 2002;277(41):38468-75.
2002: Stephanie Runkle; Julie Hill; Marc Kantorow; Joseph Horwitz; Mason Posner
Sequence and spatial expression of zebrafish (Danio rerio) alphaA-crystallin.
Molecular vision 2002;8():45-50.
2002: WeiYan Zhang; John Hawse; QingLing Huang; Nancy L Sheets; Kevin M Miller; Joseph Horwitz; Marc Kantorow
Decreased expression of ribosomal proteins in human age-related cataract.
Investigative ophthalmology & visual science 2002;43(1):198-204.
2000: Kristine Magabo; Joseph Horwitz; Joram Piatigorsky; Marc Kantorow
Expression of betaB(2)-crystallin mRNA and protein in retina, brain, and testis.
Investigative ophthalmology & visual science 2000;41(10):3056-60.
2000: Marc Kantorow; Q Huang; X J Yang; E H Sage; Kristine Magabo; K M Miller; Joseph Horwitz
Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.
Molecular vision 2000;6():24-9.
2000: Joseph Horwitz
The function of alpha-crystallin in vision.
Seminars in cell & developmental biology 2000;11(1):53-60.
1999: Mason Posner; Marc Kantorow; Joseph Horwitz
Cloning, sequencing and differential expression of alphaB-crystallin in the zebrafish, Danio rerio.
Biochimica et biophysica acta 1999;1447(2-3):271-7.
1999: Joseph Horwitz; Michael P Bova; Lin Lin Ding; DA Haley; Phoebe L Stewart
Lens alpha-crystallin: function and structure.
Eye (London, England) 1999;13 ( Pt 3b)():403-8.
1999: Michael P Bova; Orna Yaron; Q Huang; Linlin Ding; DA Haley; Phoebe L Stewart; Joseph Horwitz
Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6137-42.
1999: DA Haley; Joseph Horwitz; Phoebe L Stewart
Image restrained modeling of alphaB-crystallin.
Experimental eye research 1999;68(1):133-6.
1998: Marc Kantorow; T Kays; Joseph Horwitz; Q Huang; J Sun; Joram Piatigorsky; D Carper
Differential display detects altered gene expression between cataractous and normal human lenses.
Investigative ophthalmology & visual science 1998;39(12):2344-54.
1998: Marc Kantorow; Joseph Horwitz; D Carper
Up-regulation of osteonectin/SPARC in age-related cataractous human lens epithelia.
Molecular vision 1998;4():17.
1998: Joseph Horwitz; Michael P Bova; Qing Ling Huang; Linlin Ding; Orna Yaron; S Lowman
Mutation of alpha B-crystallin: effects on chaperone-like activity.
International journal of biological macromolecules 1998;22(3-4):263-9.
1998: DA Haley; Joseph Horwitz; Phoebe L Stewart
The small heat-shock protein, alphaB-crystallin, has a variable quaternary structure.
Journal of molecular biology 1998;277(1):27-35.
1998: Ben J Glasgow; Adil R Abduragimov; Taleh N Yusifov; Oktay Gasymov; Joseph Horwitz; Wayne L Hubbell; Kym F Faull
A conserved disulfide motif in human tear lipocalins influences ligand binding.
Biochemistry 1998;37(8):2215-25.
1998: Joseph Horwitz; Qing Ling Huang; Linlin Ding; Michael P Bova
Lens alpha-crystallin: chaperone-like properties.
Methods in enzymology 1998;290():365-83.
1997: Michael P Bova; Lin Lin Ding; Joseph Horwitz; Bernard K Fung
Subunit exchange of alphaA-crystallin.
The Journal of biological chemistry 1997;272(47):29511-7.
1995: Z T Farahbakhsh; Qing Ling Huang; Lin Lin Ding; Christian Altenbach; Heinz-Jürgen Steinhoff; Joseph Horwitz; Wayne L Hubbell
Interaction of alpha-crystallin with spin-labeled peptides.
Biochemistry 1995;34(2):509-16.
1994: Margaret H Garner; Joseph Horwitz
Catalytic subunit isoforms of mammalian lens Na,K-ATPase.
Current eye research 1994;13(1):65-77.
1993: Larry Takemoto; T Emmons; Joseph Horwitz
The C-terminal region of alpha-crystallin: involvement in protection against heat-induced denaturation.
The Biochemical journal 1993;294 ( Pt 2)():435-8.
1993: Qing Ling Huang; M F Lou; B R Straatsma; Joseph Horwitz
Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia.
Current eye research 1993;12(5):433-7.
1993: Joseph Horwitz
Proctor Lecture. The function of alpha-crystallin.
Investigative ophthalmology & visual science 1993;34(1):10-22.
1992: Joseph Horwitz
Alpha-crystallin can function as a molecular chaperone.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10449-53.
1992: Joseph Horwitz; T Emmons; Larry Takemoto
The ability of lens alpha crystallin to protect against heat-induced aggregation is age-dependent.
Current eye research 1992;11(8):817-22.
1992: Larry Takemoto; Joseph Horwitz; T Emmons
Oxidation of the N-terminal methionine of lens alpha-A crystallin.
Current eye research 1992;11(7):651-5.
1991: Suraj Bhat; Joseph Horwitz; A Srinivasan; Linlin Ding
Alpha B-crystallin exists as an independent protein in the heart and in the lens.
European journal of biochemistry / FEBS 1991;202(3):775-81.
1991: B R Straatsma; D O Lightfoot; R M Barke; Joseph Horwitz
Lens capsule and epithelium in age-related cataract.
American journal of ophthalmology 1991;112(3):283-96.
1989: Larry Takemoto; B Straatsma; Joseph Horwitz
Immunochemical characterization of the major low molecular weight polypeptide (10K) from human cataractous lenses.
Experimental eye research 1989;48(2):261-70.
1989: Larry Takemoto; Joseph Horwitz; J Kuck; K Kuck
A covalent change in alpha crystallin during opacification of the Emory mouse lens.
Lens and eye toxicity research 1989;6(3):431-41.
1987: Joseph Horwitz; Dean Bok
Conformational properties of the main intrinsic polypeptide (MIP26) isolated from lens plasma membranes.
Biochemistry 1987;26(25):8092-8.
1987: Joseph Horwitz; A Dovrat; B R Straatsma; P J Revilla; D O Lightfoot
Glutathione reductase in human lens epithelium: FAD-induced in vitro activation.
Current eye research 1987;6(10):1249-56.
1987: Larry Takemoto; D Takemoto; G Brown; M Takehana; J Smith; Joseph Horwitz
Cleavage from the N-terminal region of beta Bp crystallin during aging of the human lens.
Experimental eye research 1987;45(3):385-92.
1986: Larry Takemoto; M Takehana; Joseph Horwitz
Antisera to synthetic peptides of MIP26K as probes of membrane changes during human cataractogenesis.
Experimental eye research 1986;42(5):497-501.
1986: Larry Takemoto; M Takehana; Joseph Horwitz
Covalent changes in MIP26K during aging of the human lens membrane.
Investigative ophthalmology & visual science 1986;27(3):443-6.
1985: B R Straatsma; Joseph Horwitz; J G Flannery; D O Lightfoot; L L Ding
Aging-related cataract: clinical studies and biochemical correlations.
Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu 1985;1(2):111-6.
1985: M J McFall-Ngai; L L Ding; Larry Takemoto; Joseph Horwitz
Spatial and temporal mapping of the age-related changes in human lens crystallins.
Experimental eye research 1985;41(6):745-58.
1985: Larry Takemoto; J S Hansen; Joseph Horwitz
Antisera to synthetic peptides of lens MIP26K (major intrinsic polypeptide): characterization and use as site-specific probes of membrane changes in the aging human lens.
Experimental eye research 1985;41(3):415-22.
1985: J. SAMUEL ZIGLER; P Russell; Larry Takemoto; S J Schwab; J S Hansen; Joseph Horwitz; J H Kinoshita
Partial characterization of three distinct populations of human gamma-crystallins.
Investigative ophthalmology & visual science 1985;26(4):525-31.
1985: Larry Takemoto; J S Hansen; J. SAMUEL ZIGLER; Joseph Horwitz
Characterization of polypeptides from human nuclear cataracts by Western blot analysis.
Experimental eye research 1985;40(2):205-12.
1984: Larry Takemoto; J S Hansen; Joseph Horwitz
High molecular weight aggregates from human cataracts: characterization by Western blot analysis.
Biochemical and biophysical research communications 1984;122(3):1028-33.
1984: B R Straatsma; Joseph Horwitz; L J Takemoto; D O Lightfoot; L L Ding
Clinicobiochemical correlations in aging-related human cataract. The Pan American Association and American Journal of Ophthalmology lecture.
American journal of ophthalmology 1984;97(4):457-69.
1983: L J Takemoto; J S Hansen; Bruce Nicholson; M Hunkapiller; J P Revel; Joseph Horwitz
Major intrinsic polypeptide of lens membrane. Biochemical and immunological characterization of the major cyanogen bromide fragment.
Biochimica et biophysica acta 1983;731(2):267-74.
1983: Joseph Horwitz; J S Hansen; C C Cheung; L L Ding; B R Straatsma; D O Lightfoot; Larry Takemoto
Presence of low molecular weight polypeptides in human brunescent cataracts.
Biochemical and biophysical research communications 1983;113(1):65-71.
1982: Larry Takemoto; J S Hansen; Joseph Horwitz
Biochemical analysis of microdissected sections from the normal and cataractous human lens.
Current eye research 1982;2(7):443-50.
1982: Larry Takemoto; J S Hansen; Joseph Horwitz
Comparison of in vitro proteolysis products of the normal human lens with putative in vivo proteolysis products of the cataractous lens.
Current eye research 1982;2(12):849-54.