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Marshall Horwitz

Research Profile

Chemicals & Drugs

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Chromosomes, Human, Pair 16

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Publications

TOP 3
Kathleen F Benson; Marshall Horwitz
Familial leukemia.
Zhijun Duan; Adrian Zarebski; Diego Montoya-Durango; H Leighton Grimes; Marshall Horwitz
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
Zhijun Duan; Marshall Horwitz
Gfi-1 takes center stage in hematopoietic stem cells.

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All Publications

2006: Kathleen F Benson; Marshall Horwitz
Familial leukemia.
Best practice & research. Clinical haematology 2006;19(2):269-79.
2005: Zhijun Duan; Adrian Zarebski; Diego Montoya-Durango; H Leighton Grimes; Marshall Horwitz
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1.
Molecular and cellular biology 2005;25(23):10338-51.
2005: Zhijun Duan; Marshall Horwitz
Gfi-1 takes center stage in hematopoietic stem cells.
Trends in molecular medicine 2005;11(2):49-52.
2004: Robert Escher; Antonia Jones; Fitsum G Hagos; Catherine Carmichael; Marshall Horwitz; Olufunmilayo I Olopade; Hamish Scott
Chromosome band 16q22-linked familial AML: exclusion of candidate genes, and possible disease risk modification by NQO1 polymorphisms.
Genes, chromosomes & cancer 2004;41(3):278-82.
2004: Marshall Horwitz; Kathleen F Benson; Zhijun Duan; Feng-Qian Li; Richard E Person
Hereditary neutropenia: dogs explain human neutrophil elastase mutations.
Trends in molecular medicine 2004;10(4):163-70.
2004: Robert Escher; Fitsum G Hagos; Joäelle Michaud; Lise Sveen; Marshall Horwitz; Olufunmilayo I Olopade; Hamish Scott
No evidence for core-binding factor CBFbeta as a leukemia predisposing factor in chromosome 16q22-linked familial AML.
Leukemia 2004;18(4):881.
2004: Ding-You Li; ANN SCHEIMANN; J Glenn Songer; Richard E Person; Marshall Horwitz; Linda M. Resar; Kathleen B Schwarz
Enteritis necroticans with recurrent enterocutaneous fistulae caused by Clostridium perfringens in a child with cyclic neutropenia.
Journal of pediatric gastroenterology and nutrition 2004;38(2):213-5.
2004: Feng-Qian Li; Richard E Person; Ken-Ichi Takemaru; Kayleen Williams; Kimberly Meade-White; Ayse H Ozsahin; Tayfun Güngör; Randall T Moon; Marshall Horwitz
Lymphoid enhancer factor-1 links two hereditary leukemia syndromes through core-binding factor alpha regulation of ELA2.
The Journal of biological chemistry 2004;279(4):2873-84.
2004: Kathleen F Benson; Richard E Person; Feng-Qian Li; Kayleen Williams; Marshall Horwitz
Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia.
Nucleic acids research 2004;32(21):6327-33.
2004: loretta doan; Susan D Porter; Zhijun Duan; Marcella M Flubacher; Diego Montoya; Philip Tsichlis; Marshall Horwitz; C Blake Gilks; H Leighton Grimes
Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.
Nucleic acids research 2004;32(8):2508-19.
2004: Zhijun Duan; Feng-Qian Li; Jeremy Wechsler; Kimberly Meade-White; Kayleen Williams; Kathleen F Benson; Marshall Horwitz
A novel notch protein, N2N, targeted by neutrophil elastase and implicated in hereditary neutropenia.
Molecular and cellular biology 2004;24(1):58-70.
2003: Zhijun Duan; Marshall Horwitz
Gfi-1 oncoproteins in hematopoiesis.
Hematology (Amsterdam, Netherlands) 2003;8(5):339-44.
2003: Kathleen F Benson; Feng-Qian Li; Richard E Person; Dalila Albani; Zhijun Duan; Jeremy Wechsler; Kimberly Meade-White; Kayleen Williams; Gregory M Acland; Glenn Niemeyer; Clinton D Lothrop; Marshall Horwitz
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase.
Nature genetics 2003;35(1):90-6.
2003: Richard E Person; Feng-Qian Li; Zhijun Duan; Kathleen F Benson; Jeremy Wechsler; Helen A Papadaki; George Miltiades Eliopoulos; Christina Kaufman; Salvatore J Bertolone; Betty Nakamoto; Thalia Papayannopoulou; H Leighton Grimes; Marshall Horwitz
Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2.
Nature genetics 2003;34(3):308-12.
2003: Zhijun Duan; Marshall Horwitz
Targets of the transcriptional repressor oncoprotein Gfi-1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):5932-7.
2003: Helen A Papadaki; Marshall Horwitz; Stavroula A Coulocheri; Richard A Person; Kathleen F Benson; George D Eliopoulos
Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia.
Blood 2003;101(7):2898-9.
2003: Marshall Horwitz; Feng-Qian Li; Dalila Albani; Zhijun Duan; Richard E Person; Kimberly Meade-White; Kathleen F Benson
Leukemia in severe congenital neutropenia: defective proteolysis suggests new pathways to malignancy and opportunities for therapy.
Cancer investigation 2003;21(4):579-87.
2003: Marshall Horwitz; Kathleen F Benson; Zhijun Duan; Richard E Person; Jeremy Wechsler; Kayleen Williams; Dalila Albani; Feng-Qian Li
Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesis.
Current opinion in hematology 2003;10(1):49-54.
2002: David S Grenda; Sonja E Johnson; Jill R Mayer; Morgan L McLemore; Kathleen F Benson; Marshall Horwitz; Daniel C Link
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.
Blood 2002;100(9):3221-8.
2002: Kathleen F Benson; Marshall Horwitz
Possibility of somatic mosaicism of ELA2 mutation overlooked in an asymptomatic father transmitting severe congenital neutropenia to two offspring.
British journal of haematology 2002;118(3):923; author reply 923-4.
2002: Joäelle Michaud; Feng Wu; Motomi Osato; Gregory M Cottles; Masatoshi Yanagida; Norio Asou; Shigesada Katsuya; Yoshiaki Ito; Kathleen F Benson; Wendy H Raskind; Colette Rossier; Stylianos E Antonarakis; Sara J Israels; Archibald McNicol; Harvey Weiss; Marshall Horwitz; Hamish Scott
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis.
Blood 2002;99(4):1364-72.
2001: Feng-Qian Li; Marshall Horwitz
Characterization of mutant neutrophil elastase in severe congenital neutropenia.
The Journal of biological chemistry 2001;276(17):14230-41.
2000: David C Dale; Richard E Person; Audrey Anna Bolyard; Andrew A G Aprikyan; C Bos; Mary Ann Bonilla; Laurence A Boxer; George Kannourakis; Cornelia Zeidler; Karl Welte; Kathleen F Benson; Marshall Horwitz
Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia.
Blood 2000;96(7):2317-22.
2000: Feng-Qian Li; A Coonrod; Marshall Horwitz
Selection of a dominant negative retinoblastoma protein (RB) inhibiting satellite myoblast differentiation implies an indirect interaction between MyoD and RB.
Molecular and cellular biology 2000;20(14):5129-39.
2000: Q Gao; Marshall Horwitz; Diane Roulston; Fitsum G Hagos; N Zhao; E J Freireich; HM Golomb; Olufunmilayo I Olopade
Susceptibility gene for familial acute myeloid leukemia associated with loss of 5q and/or 7q is not localized on the commonly deleted portion of 5q.
Genes, chromosomes & cancer 2000;28(2):164-72.
1999: Marshall Horwitz; Kathleen F Benson; Richard E Person; Andrew A G Aprikyan; David C Dale
Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.
Nature genetics 1999;23(4):433-6.
1999: Marshall Horwitz; P H Wiernik
Pseudoautosomal linkage of Hodgkin disease.
American journal of human genetics 1999;65(5):1413-22.
1998: Kathleen F Benson; Marshall Horwitz; John Wolff; Kathryn Friend; E Thompson; S White; Robert I Richards; Wendy H Raskind; Thomas D Bird
CAG repeat expansion in autosomal dominant familial spastic paraparesis: novel expansion in a subset of patients.
Human molecular genetics 1998;7(11):1779-86.
1997: A Coonrod; Feng-Qian Li; Marshall Horwitz
On the mechanism of DNA transfection: efficient gene transfer without viruses.
Gene therapy 1997;4(12):1313-21.
1997: Marshall Horwitz; Kathleen F Benson; Feng-Qian Li; John Wolff; M F Leppert; Lynne Hobson; Marie Mangelsdorf; S Yu; DR Hewett; Robert I Richards; Wendy H Raskind
Genetic heterogeneity in familial acute myelogenous leukemia: evidence for a second locus at chromosome 16q21-23.2.
American journal of human genetics 1997;61(4):873-81.
1997: Marshall Horwitz
The genetics of familial leukemia.
Leukemia 1997;11(8):1347-59.
1996: Feng-Qian Li; A Coonrod; Marshall Horwitz
Preferential MyoD homodimer formation demonstrated by a general method of dominant negative mutation employing fusion with a lysosomal protease.
The Journal of cell biology 1996;135(4):1043-57.
1996: Marshall Horwitz; Ellen L Goode; Gail P Jarvik
Anticipation in familial leukemia.
American journal of human genetics 1996;59(5):990-8.
1996: Marshall Horwitz; Daniel E Sabath; W A Smithson; J Radich
A family inheriting different subtypes of acute myelogenous leukemia.
American journal of hematology 1996;52(4):295-304.