FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Hosfield

Research Profile

Chemicals & Drugs

Concepts & Ideas

Living Beings

Physiology

DNA Repair

Procedures

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
Zhe Nie; Robert Skene; Jeffrey Stafford; Noriko Uchiyama; Lilly Zhang; Hua Zou; Nobuyuki Amano; Xiaodong Cao; Victoria Feher; Kouki Hikami; Yuichi Hikichi; David J Hosfield; Benjamin Jones; Stephen Kaldor; Tomohiro Kawamoto; Andre Kiryanov; Betty Lam; Yan Liu; Shin-Ichi Matsumoto; Christopher McBride; Srinivasa Natala; Takashi Ichikawa
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Zacharia S Cheruvallath; Jun Feng; Prasuna Guntupalli; Stephen L Gwaltney; David J Hosfield; Andy Jennings; Bumsup Lee; Joanne Miura; Mark Sabat; Mingnam Tang; Haixia Wang; Yiqin Wu
Design, synthesis and SAR of novel glucokinase activators.
Susan Tsutakawa; Andrew S Arvai; Richard P Cunningham; Kenneth A Frankel; Kenichi Hitomi; David J Hosfield; Ivaylo N Ivanov; Tadahide Izumi; Buddhadev Maiti; Anil K Mantha; Sankar Mitra; Clifford D Mol; Mike E Pique; David S Shin; Bartosz Szczesny; John A Tainer
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Hosfield (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Zhe Nie; Robert Skene; Jeffrey Stafford; Noriko Uchiyama; Lilly Zhang; Hua Zou; Nobuyuki Amano; Xiaodong Cao; Victoria Feher; Kouki Hikami; Yuichi Hikichi; David J Hosfield; Benjamin Jones; Stephen Kaldor; Tomohiro Kawamoto; Andre Kiryanov; Betty Lam; Yan Liu; Shin-Ichi Matsumoto; Christopher McBride; Srinivasa Natala; Takashi Ichikawa
Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorganic & medicinal chemistry letters 2013;23(12):3662-6.
2013: Zacharia S Cheruvallath; Jun Feng; Prasuna Guntupalli; Stephen L Gwaltney; David J Hosfield; Andy Jennings; Bumsup Lee; Joanne Miura; Mark Sabat; Mingnam Tang; Haixia Wang; Yiqin Wu
Design, synthesis and SAR of novel glucokinase activators.
Bioorganic & medicinal chemistry letters 2013;23(7):2166-71.
2013: Susan Tsutakawa; Andrew S Arvai; Richard P Cunningham; Kenneth A Frankel; Kenichi Hitomi; David J Hosfield; Ivaylo N Ivanov; Tadahide Izumi; Buddhadev Maiti; Anil K Mantha; Sankar Mitra; Clifford D Mol; Mike E Pique; David S Shin; Bartosz Szczesny; John A Tainer
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
The Journal of biological chemistry 2013;288(12):8445-55.
2013: Naoki Tomita; Yoshio Aramaki; Yoshiko Awazu; Yoko Hayashi; Akira Hori; David J Hosfield; Osamu Isono; Hidehisa Iwata; Misa Iwatani; Tomohiro Kawamoto; Yoshihiro Matsushita; Hiroshi Miki; Atsutoshi Okabe; Yoshimasa Oomori; Robert J Skene; Shinkichi Suzuki; Atsuo Baba
Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Bioorganic & medicinal chemistry letters 2013;23(6):1779-85.
2013: Misa Iwatani; Atsutoshi Okabe; Robert J Skene; Naoki Tomita; Yoshio Aramaki; Atsuo Baba; Yoko Hayashi; Akira Hori; David J Hosfield; Hidehisa Iwata; Hiroshi Miki
Discovery and characterization of novel allosteric FAK inhibitors.
European journal of medicinal chemistry 2013;61():49-60.
2013: Minna D Balbas; Yu Chen; Michael J Evans; Geoffrey L Greene; David J Hosfield; Yang Shen; Philip A Watson; John Wongvipat; Vivek K Arora; Charles L Sawyers
Overcoming mutation-based resistance to antiandrogens with rational drug design.
eLife 2013;2():e00499.
2008: Elsa D Garcin; David J Hosfield; Brenda Osborne; Brian J Haas; Magnar Björas; Richard P Cunningham; John A Tainer
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nature structural & molecular biology 2008;15(5):515-22.
2005: David J Hosfield; Yiqin Wu; Robert J Skene; Mark Hilgers; Andy Jennings; Gyorgy P Snell; Kathleen Aertgeerts
Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
The Journal of biological chemistry 2005;280(6):4639-48.
2004: Elsa D Garcin; Christopher M Bruns; Sarah J Lloyd; David J Hosfield; Mauro Tiso; Ratan Gachhui; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: Clifford D Mol; Doriano Fabbro; David J Hosfield
Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors.
Current opinion in drug discovery & development 2004;7(5):639-48.
2004: David J Hosfield; Yanming Zhang; Douglas Dougan; Alexei Broun; Leslie W Tari; Ron Swanson; John Finn
Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis.
The Journal of biological chemistry 2004;279(10):8526-9.
2004: Brian R Chapados; David J Hosfield; Seungil Han; Junzhuan Qiu; Biana Yelent; Binghui Shen; John A Tainer
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Cell 2004;116(1):39-50.
2003: Stephen R Shouldice; Douglas Dougan; Pamela A Williams; Robert J Skene; Gyorgy Snell; Daniel Scheibe; Shane Kirby; David J Hosfield; Duncan E McRee; Anthony B Schryvers; Leslie W Tari
Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins.
The Journal of biological chemistry 2003;278(42):41093-8.
2003: David J Hosfield; John Palan; Mark Hilgers; Daniel Scheibe; Duncan E McRee; Raymond C Stevens
A fully integrated protein crystallization platform for small-molecule drug discovery.
Journal of structural biology 2003;142(1):207-17.
2002: Subrata Adak; Alexandrine M Bilwes; Koustubh Panda; David J Hosfield; kulwant aulak; John F McDonald; John A Tainer; Elizabeth D Getzoff; Brian R Crane; Dennis J Stuehr
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2001: Brian R Chapados; Qing Chai; David J Hosfield; Junzhuan Qiu; Binghui Shen; John A Tainer
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.
Journal of molecular biology 2001;307(2):541-56.
2001: David J Hosfield; Douglas S Daniels; Clifford D Mol; Christopher D Putnam; SS Parikh; John A Tainer
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.
Progress in nucleic acid research and molecular biology 2001;68():315-47.
2000: Clifford D Mol; David J Hosfield; John A Tainer
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Mutation research 2000;460(3-4):211-29.
1999: David J Hosfield; Y Guan; Brian J Haas; Richard P Cunningham; John A Tainer
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell 1999;98(3):397-408.
1999: SS Parikh; Clifford D Mol; David J Hosfield; John A Tainer
Envisioning the molecular choreography of DNA base excision repair.
Current opinion in structural biology 1999;9(1):37-47.
1998: David J Hosfield; G Frank; Y Weng; John A Tainer; Binghui Shen
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.
The Journal of biological chemistry 1998;273(42):27154-61.
1998: David J Hosfield; Clifford D Mol; Binghui Shen; John A Tainer
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell 1998;95(1):135-46.