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Hiroyuki Hosokawa

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Hiroyuki Hosokawa; Chiaki Iwamura; Akinori Kanai; Miki Kato; Shuichi Ohkubo; Atsushi Onodera; Sumio Sugano; Yutaka Suzuki; Tomoaki Tanaka; Damon John Tumes; Yusuke Endo; Kanji Endoh; Toshinori Nakayama
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.
Makoto Kuwahara; Veronique Lefebvre; Shinichiro Motohashi; Atsushi Onodera; Ryo Shinnakasu; Kenta Shinoda; Soichi Tofukuji; Damon Tumes; Masakatsu Yamashita; Hiroyuki Hosokawa; Chiaki Iwamura; Toshinori Nakayama
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.
Kenta Shinoda; Koji Tokoyoda; Damon J Tumes; Sandra Zehentmeier; Asami Hanazawa; Koji Hayashizaki; Hiroyuki Hosokawa; Chiaki Iwamura; Haruhiko Koseki; Andreas Radbruch; Toshinori Nakayama
Type II membrane protein CD69 regulates the formation of resting T-helper memory.

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All Publications

2013: Hiroyuki Hosokawa; Chiaki Iwamura; Akinori Kanai; Miki Kato; Shuichi Ohkubo; Atsushi Onodera; Sumio Sugano; Yutaka Suzuki; Tomoaki Tanaka; Damon John Tumes; Yusuke Endo; Kanji Endoh; Toshinori Nakayama
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4691-6.
2012: Makoto Kuwahara; Veronique Lefebvre; Shinichiro Motohashi; Atsushi Onodera; Ryo Shinnakasu; Kenta Shinoda; Soichi Tofukuji; Damon Tumes; Masakatsu Yamashita; Hiroyuki Hosokawa; Chiaki Iwamura; Toshinori Nakayama
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation.
Nature immunology 2012;13(8):778-86.
2012: Kenta Shinoda; Koji Tokoyoda; Damon J Tumes; Sandra Zehentmeier; Asami Hanazawa; Koji Hayashizaki; Hiroyuki Hosokawa; Chiaki Iwamura; Haruhiko Koseki; Andreas Radbruch; Toshinori Nakayama
Type II membrane protein CD69 regulates the formation of resting T-helper memory.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(19):7409-14.
2012: Ayako Inamine; Asaka Matuura-Suzuki; Toshinori Nakayama; Toyoyuki Hanazawa; Shigetoshi Horiguchi; Hiroyuki Hosokawa; Daiju Sakurai; Syuji Yonekura; Yoshitaka Okamoto
Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells.
Clinical immunology (Orlando, Fla.) 2012;143(2):170-9.
2012: Junji Yamashita; Asami Hanazawa; Hiroyuki Hosokawa; Chiaki Iwamura; Kenji Kaneko; Kunitoshi Mitsumori; Shinichiro Motohashi; Tetsuya Sasaki; Kenta Shinoda; Munehisa Takahashi; Hitoshi Tanaka; Damon Tumes; Yukiko Watanabe; Toshinori Nakayama
Murine Schnurri-2 controls natural killer cell function and lymphoma development.
Leukemia & lymphoma 2012;53(3):479-86.
2011: Yusuke Endo; Hiroyuki Hosokawa; Chiaki Iwamura; Makoto Kuwahara; Kaoru Sugaya; Akane Suzuki; Koji Tokoyoda; Damon J Tumes; Masakatsu Yamashita; Toshinori Nakayama
Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.
Immunity 2011;35(5):733-45.
2011: Shu Horiuchi; Atsushi Onodera; Hiroyuki Hosokawa; Yukiko Watanabe; Tomoaki Tanaka; Sumio Sugano; Yutaka Suzuki; Toshinori Nakayama
Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6378-89.
2010: Atsushi Onodera; Masakatsu Yamashita; Yusuke Endo; Makoto Kuwahara; Soichi Tofukuji; Hiroyuki Hosokawa; Akinori Kanai; Yutaka Suzuki; Toshinori Nakayama
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
The Journal of experimental medicine 2010;207(11):2493-506.
2010: Akane Suzuki; Chiaki Iwamura; Kenta Shinoda; Damon J Tumes; Motoko Y Kimura; Hiroyuki Hosokawa; Yusuke Endo; Shu Horiuchi; Koji Tokoyoda; Haruhiko Koseki; Masakatsu Yamashita; Toshinori Nakayama
Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(8):4510-20.
2009: Takako Miki-Hosokawa; Akihiro Hasegawa; Chiaki Iwamura; Kenta Shinoda; Soichi Tofukuji; Yukiko Watanabe; Hiroyuki Hosokawa; Shinichiro Motohashi; Kahoko Hashimoto; Mutsunori Shirai; Masakatsu Yamashita; Toshinori Nakayama
CD69 controls the pathogenesis of allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):8203-15.
2009: Masayuki Kitajima; Chiaki Iwamura; Takako Miki-Hosokawa; Kenta Shinoda; Yusuke Endo; Yukiko Watanabe; Ryo Shinnakasu; Hiroyuki Hosokawa; Kahoko Hashimoto; Shinichiro Motohashi; Haruhiko Koseki; Osamu Ohara; Masakatsu Yamashita; Toshinori Nakayama
Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5388-96.
2009: Azusa Nagata; Tomoaki Tanaka; Asami Minezawa; Masha Poyurovsky; Takafumi Mayama; Sawako Suzuki; Naoko Hashimoto; Tomohiko Yoshida; Keiko Suyama; Atsuro Miyata; Hiroyuki Hosokawa; Toshinori Nakayama; Ichiro Tatsuno
cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells.
Journal of cellular physiology 2009;221(1):75-83.
2008: Mohammad B Hossain; Hiroyuki Hosokawa; Akihiro Hasegawa; Hiroshi Watarai; Masaru Taniguchi; Masakatsu Yamashita; Toshinori Nakayama
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.
Immunology 2008;125(3):377-86.
2008: Ryo Shinnakasu; Masakatsu Yamashita; Makoto Kuwahara; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinichiro Motohashi; Toshinori Nakayama
Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.
The Journal of biological chemistry 2008;283(42):28216-25.
2008: Toshihiro Ito; Akihiro Hasegawa; Hiroyuki Hosokawa; Masakatsu Yamashita; Shinichiro Motohashi; Takashi Naka; Yuko Okamoto; Yukiko Fujita; Yasuyuki Ishii; Masaru Taniguchi; Ikuya Yano; Toshinori Nakayama
Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.
International immunology 2008;20(7):849-60.
2008: Masakatsu Yamashita; Makoto Kuwahara; Akane Suzuki; Kiyoshi Hirahara; Ryo Shinnaksu; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinichiro Motohashi; Atsushi Iwama; Toshinori Nakayama
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.
The Journal of experimental medicine 2008;205(5):1109-20.
2007: Takaaki Kaneko; Hiroyuki Hosokawa; Masakatsu Yamashita; Chrong-Reen Wang; Akihiro Hasegawa; Motoko Y Kimura; Masayuki Kitajiama; Fumio Kimura; Masaru Miyazaki; Toshinori Nakayama
Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.
Molecular immunology 2007;44(9):2249-56.
2006: Hiroyuki Hosokawa; Motoko Y Kimura; Ryo Shinnakasu; Akane Suzuki; Takako Miki; Haruhiko Koseki; Maarten van Lohuizen; Masakatsu Yamashita; Toshinori Nakayama
Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7656-64.
2006: Ryo Shinnakasu; Masakatsu Yamashita; Kenta Shinoda; Yusuke Endo; Hiroyuki Hosokawa; Akihiro Hasegawa; Shinji Ikemizu; Toshinori Nakayama
Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5801-10.
2006: Masakatsu Yamashita; Kiyoshi Hirahara; Ryo Shinnakasu; Hiroyuki Hosokawa; Satoko Norikane; Motoko Y Kimura; Akihiro Hasegawa; Toshinori Nakayama
Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.
Immunity 2006;24(5):611-22.
2006: Akihiro Hasegawa; Takako Miki; Hiroyuki Hosokawa; Mohammad B Hossain; Chiori Shimizu; Kahoko Hashimoto; Motoko Y Kimura; Masakatsu Yamashita; Toshinori Nakayama
Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2546-54.
2005: Motoko Y Kimura; Hiroyuki Hosokawa; Masakatsu Yamashita; Akihiro Hasegawa; Chiaki Iwamura; Hiroshi Watarai; Masaru Taniguchi; Tsuyoshi Takagi; Shunsuke Ishii; Toshinori Nakayama
Regulation of T helper type 2 cell differentiation by murine Schnurri-2.
The Journal of experimental medicine 2005;201(3):397-408.
2004: Takuo Katsumoto; Motoko Kimura; Masakatsu Yamashita; Hiroyuki Hosokawa; Kahoko Hashimoto; Akihiro Hasegawa; Miyuki Omori; Takeshi Miyamoto; Masaru Taniguchi; Toshinori Nakayama
STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4967-75.
2004: Masakatsu Yamashita; Maki Ukai-Tadenuma; Takeshi Miyamoto; Kaoru Sugaya; Hiroyuki Hosokawa; Akihiro Hasegawa; Motoko Kimura; Masaru Taniguchi; James DeGregori; Toshinori Nakayama
Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.
The Journal of biological chemistry 2004;279(26):26983-90.
2003: Miyuki Omori; Masakatsu Yamashita; Masamichi Inami; Maki Ukai-Tadenuma; Motoko Kimura; Yukiko Nigo; Hiroyuki Hosokawa; Akihiro Hasegawa; Masaru Taniguchi; Toshinori Nakayama
CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA.
Immunity 2003;19(2):281-94.
2003: Kaoru Murata; Masamichi Inami; Akihiro Hasegawa; Shuichi Kubo; Motoko Kimura; Masakatsu Yamashita; Hiroyuki Hosokawa; Tomokazu Nagao; Kazuo Suzuki; Kahoko Hashimoto; Hiroshi Shinkai; Haruhiko Koseki; Masaru Taniguchi; Steven F Ziegler; Toshinori Nakayama
CD69-null mice protected from arthritis induced with anti-type II collagen antibodies.
International immunology 2003;15(8):987-92.