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Giuseppe Attardi

Research Profile

Chemicals & Drugs

Anatomy

Physiology

Disorders

MERRF Syndrome

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Molecular Sequence Data

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Publications

TOP 3
Ai Chen; Anne Chomyn; Nicola Raule; Giuseppe Attardi
Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity.
Nahoko Iwata; Jin Zhang; Gil Atzmon; Suzanne Leanza; Jaehyoung Cho; Anne Chomyn; Robert D Burk; Nir Barzilai; Giuseppe Attardi
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Petr Hájek; Anne Chomyn; Giuseppe Attardi
Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.

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All Publications

2012: Ai Chen; Anne Chomyn; Nicola Raule; Giuseppe Attardi
Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity.
PloS one 2012;7(10):e46473.
2007: Nahoko Iwata; Jin Zhang; Gil Atzmon; Suzanne Leanza; Jaehyoung Cho; Anne Chomyn; Robert D Burk; Nir Barzilai; Giuseppe Attardi
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.
Mitochondrion 2007;7(4):267-72.
2007: Petr Hájek; Anne Chomyn; Giuseppe Attardi
Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.
The Journal of biological chemistry 2007;282(8):5670-81.
2007: Gaetano Villani; Giuseppe Attardi
Polarographic assays of respiratory chain complex activity.
Methods in cell biology 2007;80():121-33.
2006: Stéphane Duvezin-Caubet; Ravi Jagasia; Johannes Wagener; Sabine Hofmann-Thiel; Aleksandra Trifunovic; Anna Hansson; Anne Chomyn; Matthias F Bauer; Giuseppe Attardi; Nils-Göran Larsson; Walter Neupert; Andreas S Reichert
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.
The Journal of biological chemistry 2006;281(49):37972-9.
2006: David W Walker; Petr Hájek; Julien Muffat; Dan Knoepfle; Stephanie Cornelison; Giuseppe Attardi; Seymour Benzer
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16382-7.
2005: Miguel Martin; Jaehyoung Cho; Anthony J Cesare; Jack D Griffith; Giuseppe Attardi
Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis.
Cell 2005;123(7):1227-40.
2004: Jennifer Fish; Nicola Raule; Giuseppe Attardi
Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis.
Science (New York, N.Y.) 2004;306(5704):2098-101.
2004: Jordi Asin-Cayuela; Mark Helm; Giuseppe Attardi
A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity.
The Journal of biological chemistry 2004;279(15):15670-7.
2004: Yidong Bai; Peiqing Hu; Jeong Soon Park; Jian-Hong Deng; Xiufeng Song; Anne Chomyn; Takao Yagi; Giuseppe Attardi
Genetic and functional analysis of mitochondrial DNA-encoded complex I genes.
Annals of the New York Academy of Sciences 2004;1011():272-83.
2004: Mark Helm; Giuseppe Attardi
Nuclear control of cloverleaf structure of human mitochondrial tRNA(Lys).
Journal of molecular biology 2004;337(3):545-60.
2003: Marilena Greco; Gaetano Villani; Franca Mazzucchelli; Nereo Bresolin; Sergio Papa; Giuseppe Attardi
Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1706-8.
2003: Anne Chomyn; Giuseppe Attardi
MtDNA mutations in aging and apoptosis.
Biochemical and biophysical research communications 2003;304(3):519-29.
2003: Jin Zhang; Jordi Asin-Cayuela; Jennifer Fish; Yuichi Michikawa; Massimiliano Bonafe; Fabiola Olivieri; Giuseppe Passarino; Giovanna De Benedictis; Claudio Franceschi; Giuseppe Attardi
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1116-21.
2003: Shili Duan; Petr Hajek; Catherine Lin; Soo Kyung Shin; Giuseppe Attardi; Anne Chomyn
Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis.
The Journal of biological chemistry 2003;278(2):1346-53.
2002: Giuseppe Attardi
Role of mitochondrial DNA in human aging.
Mitochondrion 2002;2(1-2):27-37.
2002: Giuseppe Attardi; José A Enriquez; Juan Cabezas-Herrera
Inter-mitochondrial complementation of mtDNA mutations and nuclear context.
Nature genetics 2002;30(4):360; author reply 361.
2002: Yuichi Michikawa; Giuseppe Attardi
Screening for aging-dependent point mutations in mtDNA.
Methods in molecular biology (Clifton, N.J.) 2002;197():75-92.
2001: Yidong Bai; Petr Hájek; Anne Chomyn; E Chan; Byoung Boo Seo; Akemi Matsuno-Yagi; T Yagi; Giuseppe Attardi
Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene.
The Journal of biological chemistry 2001;276(42):38808-13.
2001: Y Wang; Yuichi Michikawa; C Mallidis; Y Bai; Linda Woodhouse; K E Yarasheski; C A Miller; Valerie Askanas; W King Engel; S Bhasin; Giuseppe Attardi
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):4022-7.
2001: MX Guan; Nathan Fischel-Ghodsian; Giuseppe Attardi
Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation.
Human molecular genetics 2001;10(6):573-80.
2001: Petr Hájek; Gaetano Villani; Giuseppe Attardi
Rate-limiting step preceding cytochrome c release in cells primed for Fas-mediated apoptosis revealed by analysis of cellular mosaicism of respiratory changes.
The Journal of biological chemistry 2001;276(1):606-15.
2001: Gaetano Villani; Giuseppe Attardi
In vivo measurements of respiration control by cytochrome c oxidase and in situ analysis of oxidative phosphorylation.
Methods in cell biology 2001;65():119-31.
2001: R S Puranam; Giuseppe Attardi
The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.
Molecular and cellular biology 2001;21(2):548-61.
2000: Wolfram S Kunz; Alexei P Kudin; Stefan Vielhaber; Christian E Elger; Giuseppe Attardi; Gaetano Villani
Flux control of cytochrome c oxidase in human skeletal muscle.
The Journal of biological chemistry 2000;275(36):27741-5.
2000: Gaetano Villani; Giuseppe Attardi
In vivo control of respiration by cytochrome c oxidase in human cells.
Free radical biology & medicine 2000;29(3-4):202-10.
2000: MX Guan; Nathan Fischel-Ghodsian; Giuseppe Attardi
A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity.
Human molecular genetics 2000;9(12):1787-93.
2000: Anne Chomyn; José A Enriquez; V Micol; P Fernandez-Silva; Giuseppe Attardi
The mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode syndrome-associated human mitochondrial tRNALeu(UUR) mutation causes aminoacylation deficiency and concomitant reduced association of mRNA with ribosomes.
The Journal of biological chemistry 2000;275(25):19198-209.
2000: José Antonio Enríquez; Juan Cabezas-Herrera; Maria Pilar Bayona-Bafaluy; Giuseppe Attardi
Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells.
The Journal of biological chemistry 2000;275(15):11207-15.
2000: Yidong Bai; R M Shakeley; Giuseppe Attardi
Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria.
Molecular and cellular biology 2000;20(3):805-15.
1999: Yuichi Michikawa; K Laderman; K Richter; Giuseppe Attardi
Role of nuclear background and in vivo environment in variable segregation behavior of the aging-dependent T414G mutation at critical control site for human fibroblast mtDNA replication.
Somatic cell and molecular genetics 1999;25(5-6):333-42.
1999: Yuichi Michikawa; F Mazzucchelli; Nereo Bresolin; G Scarlato; Giuseppe Attardi
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.
Science (New York, N.Y.) 1999;286(5440):774-9.
1999: Mark Helm; Catherine Florentz; Anne Chomyn; Giuseppe Attardi
Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR).
Nucleic acids research 1999;27(3):756-63.
1998: Gaetano Villani; M Greco; S Papa; Giuseppe Attardi
Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types.
The Journal of biological chemistry 1998;273(48):31829-36.
1998: MX Guan; José A Enriquez; Nathan Fischel-Ghodsian; R S Puranam; C P Lin; Marion A Maw; Giuseppe Attardi
The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression.
Molecular and cellular biology 1998;18(10):5868-79.
1998: Yidong Bai; Giuseppe Attardi
The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme.
The EMBO journal 1998;17(16):4848-58.
1997: L Zhou; Anne Chomyn; Giuseppe Attardi; C A Miller
Myoclonic epilepsy and ragged red fibers (MERRF) syndrome: selective vulnerability of CNS neurons does not correlate with the level of mitochondrial tRNAlys mutation in individual neuronal isolates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7746-53.
1997: V Micol; P Fernández-Silva; Giuseppe Attardi
Functional analysis of in vivo and in organello footprinting of HeLa cell mitochondrial DNA in relationship to ATP and ethidium bromide effects on transcription.
The Journal of biological chemistry 1997;272(30):18896-904.
1997: Yuichi Michikawa; G Hofhaus; L S Lerman; Giuseppe Attardi
Comprehensive, rapid and sensitive detection of sequence variants of human mitochondrial tRNA genes.
Nucleic acids research 1997;25(12):2455-63.
1997: P Fernandez-Silva; F Martinez-Azorin; V Micol; Giuseppe Attardi
The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions.
The EMBO journal 1997;16(5):1066-79.
1997: Gaetano Villani; Giuseppe Attardi
In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1166-71.
1996: José Antonio Enríquez; Giuseppe Attardi
Evidence for aminoacylation-induced conformational changes in human mitochondrial tRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8300-5.
1996: Kenneth Laderman; J R Penny; F Mazzucchelli; Nereo Bresolin; G Scarlato; Giuseppe Attardi
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells.
The Journal of biological chemistry 1996;271(27):15891-7.
1996: M X Guan; Nathan Fischel-Ghodsian; Giuseppe Attardi
Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation.
Human molecular genetics 1996;5(7):963-71.
1996: Götz Hofhaus; Donald R Johns; O Hurko; Giuseppe Attardi; Anne Chomyn
Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy.
The Journal of biological chemistry 1996;271(22):13155-61.
1996: H A Bentlage; Giuseppe Attardi
Relationship of genotype to phenotype in fibroblast-derived transmitochondrial cell lines carrying the 3243 mutation associated with the MELAS encephalomyopathy: shift towards mutant genotype and role of mtDNA copy number.
Human molecular genetics 1996;5(2):197-205.
1996: Götz Hofhaus; R M Shakeley; Giuseppe Attardi
Use of polarography to detect respiration defects in cell cultures.
Methods in enzymology 1996;264():476-83.
1996: Vicente Micol; P Fernández-Silva; Giuseppe Attardi
In vivo footprinting of human mitochondrial DNA in cultured cell systems.
Methods in enzymology 1996;264():3-11.
1996: José Antonio Enríquez; Giuseppe Attardi
Analysis of aminoacylation of human mitochondrial tRNAs.
Methods in enzymology 1996;264():183-96.
1996: Vicente Micol; P Fernández-Silva; Giuseppe Attardi
Isolation and assay of mitochondrial transcription termination factor from human cells.
Methods in enzymology 1996;264():158-73.
1996: P Fernández-Silva; Vicente Micol; Giuseppe Attardi
Mitochondrial DNA transcription initiation and termination using mitochondrial lysates from cultured human cells.
Methods in enzymology 1996;264():129-39.
1995: Giuseppe Attardi; M Yoneda; Anne Chomyn
Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems.
Biochimica et biophysica acta 1995;1271(1):241-8.
1995: J A Enriquez; Anne Chomyn; Giuseppe Attardi
MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination.
Nature genetics 1995;10(1):47-55.
1995: H A Bentlage; A J Janssen; A Chomyn; Giuseppe Attardi; John E Walker; Hermann Schägger; Rob C A Sengers; F J Trijbels
Multiple deficiencies of mitochondrial DNA- and nuclear-encoded subunits of respiratory NADH dehydrogenase detected with peptide- and subunit-specific antibodies in mitochondrial myopathies.
Biochimica et biophysica acta 1995;1234(1):63-73.
1995: Götz Hofhaus; Giuseppe Attardi
Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase.
Molecular and cellular biology 1995;15(2):964-74.
1995: M Yoneda; T Miyatake; Giuseppe Attardi
Heteroplasmic mitochondrial tRNA(Lys) mutation and its complementation in MERRF patient-derived mitochondrial transformants.
Muscle & nerve. Supplement 1995;(3):S95-101.
1995: B Kruse; N N Murdter; Giuseppe Attardi
Transcription system using a HeLa cell mitochondrial lysate.
Methods in molecular biology (Clifton, N.J.) 1995;37():179-97.
1995: M Yoneda; T Miyatake; Giuseppe Attardi
Heteroplasmic mitochondrial tRNA(Lys) mutation and its complementation in MERRF patient-derived mitochondrial transformants.
Muscle & nerve. Supplement 1995;3():S95-101.
1994: Anne Chomyn; S T Lai; R Shakeley; Nereo Bresolin; G Scarlato; Giuseppe Attardi
Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers.
American journal of human genetics 1994;54(6):966-74.
1994: M Yoneda; T Miyatake; Giuseppe Attardi
Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles.
Molecular and cellular biology 1994;14(4):2699-712.
1993: Götz Hofhaus; Giuseppe Attardi
Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product.
The EMBO journal 1993;12(8):3043-8.
1993: M P King; Giuseppe Attardi
Post-transcriptional regulation of the steady-state levels of mitochondrial tRNAs in HeLa cells.
The Journal of biological chemistry 1993;268(14):10228-37.
1993: A Daga; Vicente Micol; daniel Hess; R Aebersold; Giuseppe Attardi
Molecular characterization of the transcription termination factor from human mitochondria.
The Journal of biological chemistry 1993;268(11):8123-30.
1992: M Yoneda; Anne Chomyn; A Martinuzzi; O Hurko; Giuseppe Attardi
Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11164-8.
1992: J Lunardi; O Hurko; W King Engel; Giuseppe Attardi
The multiple ADP/ATP translocase genes are differentially expressed during human muscle development.
The Journal of biological chemistry 1992;267(22):15267-70.
1992: Anne Chomyn; A Martinuzzi; M Yoneda; A Daga; O Hurko; D Johns; S T Lai; I Nonaka; Corrado Angelini; Giuseppe Attardi
MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4221-5.
1991: J Lunardi; Giuseppe Attardi
Differential regulation of expression of the multiple ADP/ATP translocase genes in human cells.
The Journal of biological chemistry 1991;266(25):16534-40.
1991: P L Polosa; Giuseppe Attardi
Distinctive pattern and translational control of mitochondrial protein synthesis in rat brain synaptic endings.
The Journal of biological chemistry 1991;266(15):10011-7.
1991: S D Patel; R Aebersold; Giuseppe Attardi
cDNA-derived amino acid sequence of the NADH-binding 51-kDa subunit of the bovine respiratory NADH dehydrogenase reveals striking similarities to a bacterial NAD(+)-reducing hydrogenase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4225-9.
1991: Anne Chomyn; Giovanni Meola; Nereo Bresolin; S T Lai; G Scarlato; Giuseppe Attardi
In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria.
Molecular and cellular biology 1991;11(4):2236-44.
1990: Giuseppe Attardi; Anne Chomyn; M P King; B Kruse; P L Polosa; N N Murdter
Regulation of mitochondrial gene expression in mammalian cells.
Biochemical Society transactions 1990;18(4):509-13.
1990: G Pauletti; E Lai; Giuseppe Attardi
Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2955-9.
1989: M P King; Giuseppe Attardi
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.
Science (New York, N.Y.) 1989;246(4929):500-3.
1989: B Kruse; N Narasimhan; Giuseppe Attardi
Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination.
Cell 1989;58(2):391-7.
1989: N D Denslow; G S Michaels; J Montoya; Giuseppe Attardi; Thomas W O'Brien
Mechanism of mRNA binding to bovine mitochondrial ribosomes.
The Journal of biological chemistry 1989;264(14):8328-38.
1988: Anne Chomyn; S D Patel; M W Cleeter; C Ian Ragan; Giuseppe Attardi
The site of synthesis of the iron-sulfur subunits of the flavoprotein and iron-protein fractions of human NADH dehydrogenase.
The Journal of biological chemistry 1988;263(31):16395-400.
1988: M P King; Giuseppe Attardi
Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA.
Cell 1988;52(6):811-9.
1988: J Houldsworth; Giuseppe Attardi
Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):377-81.
1986: Anne Chomyn; M W Cleeter; C Ian Ragan; M Riley; R F Doolittle; Giuseppe Attardi
URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.
Science (New York, N.Y.) 1986;234(4776):614-8.
1986: P Mariottini; Anne Chomyn; R F Doolittle; Giuseppe Attardi
Antibodies against the COOH-terminal undecapeptide of subunit II, but not those against the NH2-terminal decapeptide, immunoprecipitate the whole human cytochrome c oxidase complex.
The Journal of biological chemistry 1986;261(7):3355-62.
1986: P Mariottini; Anne Chomyn; M Riley; B Cottrell; R F Doolittle; Giuseppe Attardi
Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(6):1563-7.
1986: Giuseppe Attardi; Anne Chomyn; R F Doolittle; P Mariottini; C Ian Ragan
Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():103-14.
1985: Anne Chomyn; P Mariottini; M W Cleeter; C Ian Ragan; A Matsuno-Yagi; Y Hatefi; R F Doolittle; Giuseppe Attardi
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
Nature 1985;314(6012):592-7.
1983: Anne Chomyn; P Mariottini; N Gonzalez-Cadavid; Giuseppe Attardi; Donna Strong; D Trovato; M Riley; R F Doolittle
Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(18):5535-9.
1983: P Mariottini; Anne Chomyn; Giuseppe Attardi; D Trovato; Donna Strong; R F Doolittle
Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria.
Cell 1983;32(4):1269-77.
1981: R Gelfand; Giuseppe Attardi
Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable.
Molecular and cellular biology 1981;1(6):497-511.