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Giorgio Attardo

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William Kemnitzer; Songchun Jiang; Hong Zhang; Shailaja Kasibhatla; Candace Crogan-Grundy; Charles Blais; Giorgio Attardo; Real Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Candace Crogan-Grundy; Denis Labreque; Monica Bubenick; Giorgio Attardo; Réal Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
William Kemnitzer; Songchun Jiang; Yan Wang; Shailaja Kasibhatla; Candace Crogan-Grundy; Monica Bubenik; Denis Labrecque; Réal Denis; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.

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All Publications

2008: William Kemnitzer; Songchun Jiang; Hong Zhang; Shailaja Kasibhatla; Candace Crogan-Grundy; Charles Blais; Giorgio Attardo; Real Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Bioorganic & medicinal chemistry letters 2008;18(20):5571-5.
2008: William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Candace Crogan-Grundy; Denis Labreque; Monica Bubenick; Giorgio Attardo; Réal Denis; Serge Lamothe; Henriette Gourdeau; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
Journal of medicinal chemistry 2008;51(3):417-23.
2008: William Kemnitzer; Songchun Jiang; Yan Wang; Shailaja Kasibhatla; Candace Crogan-Grundy; Monica Bubenik; Denis Labrecque; Réal Denis; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based HTS assay. Part 5: modifications of the 2- and 3-positions.
Bioorganic & medicinal chemistry letters 2008;18(2):603-7.
2005: William Kemnitzer; Shailaja Kasibhatla; Songchun Jiang; Hong Zhang; Jianghong Zhao; Shaojuan Jia; Lifen Xu; Candace Crogan-Grundy; Réal Denis; Nancy Barriault; Louis Vaillancourt; Sylvie Charron; Jennifer Dodd; Giorgio Attardo; Denis Labrecque; Serge Lamothe; Henriette Gourdeau; Ben Tseng; John Drewe; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.
Bioorganic & medicinal chemistry letters 2005;15(21):4745-51.
2004: William Kemnitzer; John Drewe; Songchun Jiang; Hong Zhang; Yan Wang; Jianghong Zhao; Shaojuan Jia; John Herich; Denis Labreque; Richard Storer; Karen Meerovitch; David Y Bouffard; Rabindra Rej; Réal Denis; Charles Blais; Serge Lamothe; Giorgio Attardo; Henriette Gourdeau; Ben Tseng; Shailaja Kasibhatla; Sui Xiong Cai
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.
Journal of medicinal chemistry 2004;47(25):6299-310.
2003: Alexei Yu Denisov; Murthy S R Madiraju; Gang Chen; Abdelkrim Khadir; Pierre Beauparlant; Giorgio Attardo; Gordon C Shore; Kalle Gehring
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix.
The Journal of biological chemistry 2003;278(23):21124-8.
2003: Monica Bubenik; Karen Meerovitch; Frédéric Bergeron; Giorgio Attardo; Laval Chan
Thiophene-based vitronectin receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(3):503-6.
2003: Karen Meerovitch; Frédéric Bergeron; Lorraine Leblond; Brigitte Grouix; Cathy Poirier; Monica Bubenik; Laval Chan; Henriette Gourdeau; Terry Bowlin; Giorgio Attardo
A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen.
Vascular pharmacology 2003;40(2):77-89.
2002: Henriette Gourdeau; Philippe Genne; Salam Kadhim; Lucie Bibeau; Olivier Duchamp; France Ouellet; Jean-Marc deMuys; David Y Bouffard; Giorgio Attardo
Antitumor activity of troxacitabine (Troxatyl) against anthracycline-resistant human xenografts.
Cancer chemotherapy and pharmacology 2002;50(6):490-6.
2002: Monica Bubenik; Rabindra Rej; Nghe Nguyen-Ba; Giorgio Attardo; France Ouellet; Laval Chan
Novel nucleotide phosphonate analogues with potent antitumor activity.
Bioorganic & medicinal chemistry letters 2002;12(21):3063-6.
2002: Lorraine Leblond; Giorgio Attardo; Bettina Hamelin; David Y Bouffard; Nghe Nguyen-Ba; Henriette Gourdeau
BCH-1868 [(-)-2-R-dihydroxyphosphinoyl-5-(S)-(guanin-9'-yl-methyl) tetrahydrofuran]: a cyclic nucleoside phosphonate with antitumor activity.
Molecular cancer therapeutics 2002;1(9):737-46.
2000: Salam Kadhim; Christopher Penney; M Lagraoui; J Heibein; Giorgio Attardo; Boulos Zacharie; T Connolly; Lyne Gagnon
Synergistic anti-tumor activity of a novel immunomodulator, BCH-1393, in combination with cyclophosphamide.
International journal of immunopharmacology 2000;22(9):659-71.
1998: Shafaat A Rabbani; P Harakidas; Terry Bowlin; Giorgio Attardo
Effect of nucleoside analogue BCH-4556 on prostate cancer growth and metastases in vitro and in vivo.
Cancer research 1998;58(15):3461-5.
1998: S D Abbott; Lyne Gagnon; M Lagraoui; Salam Kadhim; Giorgio Attardo; Boulos Zacharie; Christopher Penney
Synthesis and activity of dipeptides, linked to targeting ligands, as specific NK cell enhancers.
Journal of medicinal chemistry 1998;41(11):1909-26.
1997: Salam Kadhim; Terry Bowlin; W R Waud; E G Angers; Lucie Bibeau; J M DeMuys; K Bednarski; A Cimpoia; Giorgio Attardo
Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models.
Cancer research 1997;57(21):4803-10.
1997: Boulos Zacharie; Lyne Gagnon; Giorgio Attardo; T P Connolly; Y St-Denis; Christopher Penney
Synthesis and activity of 6-substituted purine linker amino acid immunostimulants.
Journal of medicinal chemistry 1997;40(18):2883-94.