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Makoto Hosoyamada

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Disorders

Hyperuricemia

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Publications

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Tamaki Watanabe; Masaru Doshi; Naoko H Tomioka; Masao Tsuchiya; Shigekazu Watanabe; Makoto Hosoyamada
Macrophage Migration Inhibitory Factor Is a Possible Candidate for the Induction of Microalbuminuria in Diabetic db/db Mice.
Masaru Doshi; Hidetsugu Saito; Yuichi Takiue; Makoto Hosoyamada
The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.
Makoto Yasuda; Kiyoka Kaneko; Hiroka Hachisu; Kiyoko Kaneko; Ken-ichi Mawatari; Norihiko Minoura; Kazuya Nakagomi; N Yamaoka; Makoto Hosoyamada
Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene.

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All Publications

2013: Tamaki Watanabe; Masaru Doshi; Naoko H Tomioka; Masao Tsuchiya; Shigekazu Watanabe; Makoto Hosoyamada
Macrophage Migration Inhibitory Factor Is a Possible Candidate for the Induction of Microalbuminuria in Diabetic db/db Mice.
Biological & pharmaceutical bulletin 2013;36(5):741-7.
2011: Masaru Doshi; Hidetsugu Saito; Yuichi Takiue; Makoto Hosoyamada
The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1290-4.
2011: Makoto Yasuda; Kiyoka Kaneko; Hiroka Hachisu; Kiyoko Kaneko; Ken-ichi Mawatari; Norihiko Minoura; Kazuya Nakagomi; N Yamaoka; Makoto Hosoyamada
Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1284-9.
2011: Yuichi Takiue; Makoto Hosoyamada; Masaki Kimura; Hidetsugu Saito
Enhancement of androgen action in the kidneys of transgenic mice harboring the mutant human UMOD gene.
Journal of pharmacological sciences 2011;115(3):383-9.
2010: Makoto Hosoyamada; Y Takiue; T Shibasaki; H Saito
The effect of testosterone upon the urate reabsorptive transport system in mouse kidney.
Nucleosides, nucleotides & nucleic acids 2010;29(7):574-9.
2010: Makoto Hosoyamada; Y Takiue; H Morisaki; J Cheng; M Ikawa; M Okabe; T Morisaki; K Ichida; T Hosoya; T Shibasaki
Establishment and analysis of SLC22A12 (URAT1) knockout mouse.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):314-20.
2010: Yora Nindita; Toshihiro Hamada; Udin Bahrudin; Makoto Hosoyamada; Kimiyoshi Ichida; Chisato Iwai; Sunao Urashima; Narimasa Kuwabara; Sulistiyati Bayu Utami; Einosuke Mizuta; Kensaku Yamada; Osamu Igawa; Chiaki Shigemasa; Haruaki Ninomiya; Takuya Tsuchihashi; Ichiro Hisatome
Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA.
Arzneimittel-Forschung 2010;60(4):186-8.
2009: Mariko Shimizu; Jamshid Khoshnoodi; Yoshihiro Akimoto; Hayato Kawakami; Hiroshi Hirano; Eiji Higashihara; Makoto Hosoyamada; Yuji Sekine; Ryota Kurayama; Hideaki Kurayama; Kensuke Joh; Jun Hirabayashi; Kenichi Kasai; Karl Tryggvason; Noriko Ito; Kunimasa Yan
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.
Laboratory investigation; a journal of technical methods and pathology 2009;89(2):178-95.
2008: Tomokazu Shinozaki; Masaki Kimura; Makoto Hosoyamada; Toshiaki Shibasaki
Fluvoxamine inhibits weight gain and food intake in food restricted hyperphagic Wistar rats.
Biological & pharmaceutical bulletin 2008;31(12):2250-4.
2008: Toshihiro Hamada; Kimiyoshi Ichida; Makoto Hosoyamada; Einosuke Mizuta; Kiyotaka Yanagihara; Kazuhiko Sonoyama; Shinobu Sugihara; Osamu Igawa; Tatsuo Hosoya; Akira Ohtahara; Chiaki Shigamasa; Yasutaka Yamamoto; Haruaki Ninomiya; Ichiro Hisatome
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.
American journal of hypertension 2008;21(10):1157-62.
2008: Yuichi Takiue; Makoto Hosoyamada; Takuya Yokoo; Masaki Kimura; Manami Ochiai; Kiyoko Kaneko; Kimiyoshi Ichida; Tatsuo Hosoya; Toshiaki Shibasaki
Production and characterization of transgenic mice harboring mutant human UMOD gene.
Nucleosides, nucleotides & nucleic acids 2008;27(6):596-600.
2008: Tomohito Suzuki; Kanae Momoi; Makoto Hosoyamada; Masaki Kimura; Toshiaki Shibasaki
Normal cadmium uptake in microcytic anemia mk/mk mice suggests that DMT1 is not the only cadmium transporter in vivo.
Toxicology and applied pharmacology 2008;227(3):462-7.
2008: Yuichi Takiue; Makoto Hosoyamada; Takuya Yokoo; Masaki Kimura; Toshiaki Shibasaki
Progressive accumulation of intrinsic mouse uromodulin in the kidneys of transgenic mice harboring the mutant human uromodulin gene.
Biological & pharmaceutical bulletin 2008;31(3):405-11.
2006: Masaki Kimura; Tomokazu Shinozaki; Naoto Tateishi; Emi Yoda; Hideki Yamauchi; Masato Suzuki; Makoto Hosoyamada; Toshiaki Shibasaki
Adiponectin is regulated differently by chronic exercise than by weight-matched food restriction in hyperphagic and obese OLETF rats.
Life sciences 2006;79(22):2105-11.
2006: Y Fujii; Jamshid Khoshnoodi; Hitoshi Takenaka; Makoto Hosoyamada; A Nakajo; Fumio Bessho; Akihiko Kudo; Shori Takahashi; Y Arimura; A Yamada; T Nagasawa; Vesa Ruotsalainen; Karl Tryggvason; A S Lee; Kunimasa Yan
The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases.
Kidney international 2006;69(8):1350-9.
2006: Kimiyoshi Ichida; Tatsuo Hosoya; Makoto Hosoyamada
[Hyperuricemic nephropathy: Pathogenesis, pathophysiology, and therapy].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 2():438-41.
2006: Makoto Hosoyamada; Toshiaki Shibasaki; Kimiyoshi Ichida
[Molecular mechanism in biological transport in the kidney: Urate transporter URAT1].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 2():176-9.
2006: Kimiyoshi Ichida; Halil Ibrahim Aydin; Makoto Hosoyamada; H Serap Kalkanoglu; A Dursun; Iwao Ohno; Turgay Coskun; Aysegul Tokatli; Toshiaki Shibasaki; Tatsuo Hosoya
A Turkish case with molybdenum cofactor deficiency.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1087-91.
2005: Duk-Hee Kang; Lin Han; Xiaosen Ouyang; Andrew M Kahn; John Kanellis; Ping Li; Lili Feng; Takahiko Nakagawa; Susumu Watanabe; Makoto Hosoyamada; Hitoshi Endou; Michael Lipkowitz; Ruth Abramson; Wei Mu; Richard J Johnson
Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter.
American journal of nephrology 2005;25(5):425-33.
2005: Atsuo Taniguchi; Wako Urano; Mariko Yamanaka; Hisashi Yamanaka; Makoto Hosoyamada; Hitoshi Endou; Naoyuki Kamatani
A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout.
Arthritis and rheumatism 2005;52(8):2576-7.
2005: Naoki Wakida; Do Gia Tuyen; Masataka Adachi; Taku Miyoshi; Hiroshi Nonoguchi; Toshiaki Oka; Osamu Ueda; Masahiro Tazawa; Satoshi Kurihara; Yoshitaka Yoneta; Hajime Shimada; Takashi Oda; Yuichi Kikuchi; Hirotaka Matsuo; Makoto Hosoyamada; Hitoshi Endou; Masaki Otagiri; Kimio Tomita; Kenichiro Kitamura
Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia.
The Journal of clinical endocrinology and metabolism 2005;90(4):2169-74.
2005: Makoto Hosoyamada; Kunimasa Yan; Yukino Nishibori; Yuichi Takiue; Akihiko Kudo; Hayato Kawakami; Toshiaki Shibasaki; Hitoshi Endou
Nephrin and podocin expression around the onset of puromycin aminonucleoside nephrosis.
Journal of pharmacological sciences 2005;97(2):234-41.
2004: Yukino Nishibori; Li Liu; Makoto Hosoyamada; Hitoshi Endou; Akihiko Kudo; Hitoshi Takenaka; Eiji Higashihara; Fumio Bessho; Shori Takahashi; David B Kershaw; Vesa Ruotsalainen; Karl Tryggvason; Jamshid Khoshnoodi; Kunimasa Yan
Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane.
Kidney international 2004;66(5):1755-65.
2004: Naoharu Iwai; Yukari Mino; Makoto Hosoyamada; Naomi Tago; Yoshihiro Kokubo; Hitoshi Endou
A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese.
Kidney international 2004;66(3):935-44.
2004: Makoto Hosoyamada; Kimiyoshi Ichida; Atsushi Enomoto; Tatsuo Hosoya; Hitoshi Endou
Function and localization of urate transporter 1 in mouse kidney.
Journal of the American Society of Nephrology : JASN 2004;15(2):261-8.
2004: Kimiyoshi Ichida; Makoto Hosoyamada; Ichiro Hisatome; Atsushi Enomoto; Miho Hikita; Hitoshi Endou; Tatsuo Hosoya
Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion.
Journal of the American Society of Nephrology : JASN 2004;15(1):164-73.
2003: Motoko Tanaka; Kazuko Itoh; Kazunori Matsushita; Kazutaka Matsushita; Naoki Wakita; Masataka Adachi; Hiroshi Nonoguchi; Kenichiro Kitamura; Makoto Hosoyamada; Hitoshi Endou; Kimio Tomita
Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;42(6):1287-92.
2003: Promsuk Jutabha; Yoshikatsu Kanai; Makoto Hosoyamada; Arthit Chairoungdua; Do Kyung Kim; Yuji Iribe; Ellappan Babu; Ju Young Kim; Naohiko Anzai; Varanuj Chatsudthipong; Hitoshi Endou
Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule.
The Journal of biological chemistry 2003;278(30):27930-8.
2003: Masato Okubo; Kyohei Yamada; Makoto Hosoyamada; Toshiaki Shibasaki; Hitoshi Endou
Cadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes.
Toxicology and applied pharmacology 2003;187(3):162-7.
2003: Makoto Hosoyamada; Kimiyoshi Ichida
[Molecular mechanism for urinary excretion of hypoxanthine and xanthine].
Nihon rinsho. Japanese journal of clinical medicine 2003;61 Suppl 1():450-4.
2003: Kimiyoshi Ichida; Makoto Hosoyamada; Hiroaki Kimura; Michio Takeda; Yasunori Utsunomiya; Tatsuo Hosoya; Hitoshi Endou
Urate transport via human PAH transporter hOAT1 and its gene structure.
Kidney international 2003;63(1):143-55.
2002: Michio Takeda; Suparat Khamdang; Shinichi Narikawa; Hiroaki Kimura; Makoto Hosoyamada; Seok Ho Cha; Takashi Sekine; Hitoshi Endou
Characterization of methotrexate transport and its drug interactions with human organic anion transporters.
The Journal of pharmacology and experimental therapeutics 2002;302(2):666-71.
2002: Atsushi Enomoto; Hiroaki Kimura; Arthit Chairoungdua; Yasuhiro Shigeta; Promsuk Jutabha; Seok Ho Cha; Makoto Hosoyamada; Michio Takeda; Takashi Sekine; Takashi Igarashi; Hirotaka Matsuo; Yuichi Kikuchi; Takashi Oda; Kimiyoshi Ichida; Tatsuo Hosoya; Kaoru Shimokata; Toshimitsu Niwa; Yoshikatsu Kanai; Hitoshi Endou
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Nature 2002;417(6887):447-52.
2001: K Y Jung; Michio Takeda; Do Kyung Kim; Akihiro Tojo; Shinichi Narikawa; B S Yoo; Makoto Hosoyamada; Seok Ho Cha; Takashi Sekine; Hitoshi Endou
Characterization of ochratoxin A transport by human organic anion transporters.
Life sciences 2001;69(18):2123-35.
2001: Michio Takeda; Shinichi Narikawa; Makoto Hosoyamada; Seok Ho Cha; Takashi Sekine; Hitoshi Endou
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.
European journal of pharmacology 2001;419(2-3):113-20.
2000: Michio Takeda; Makoto Hosoyamada; Seok Ho Cha; Takashi Sekine; Hitoshi Endou
Hydrogen peroxide downregulates human organic anion transporters in the basolateral membrane of the proximal tubule.
Life sciences 2000;68(6):679-87.
1999: Michio Takeda; Akihiro Tojo; Takashi Sekine; Makoto Hosoyamada; Yoshikatsu Kanai; Hitoshi Endou
Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity.
Kidney international 1999;56(6):2128-36.
1999: Akihiro Tojo; Takashi Sekine; N Nakajima; Makoto Hosoyamada; Yoshikatsu Kanai; K Kimura; Hitoshi Endou
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney.
Journal of the American Society of Nephrology : JASN 1999;10(3):464-71.
1999: Makoto Hosoyamada; Takashi Sekine; Yoshikatsu Kanai; Hitoshi Endou
Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
The American journal of physiology 1999;276(1 Pt 2):F122-8.
1998: Takashi Sekine; Seok Ho Cha; Makoto Hosoyamada; Yoshikatsu Kanai; N Watanabe; Y Furuta; K Fukuda; Takashi Igarashi; Hitoshi Endou
Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter.
The American journal of physiology 1998;275(2 Pt 2):F298-305.
1997: Takashi Sekine; N Watanabe; Makoto Hosoyamada; Yoshikatsu Kanai; Hitoshi Endou
Expression cloning and characterization of a novel multispecific organic anion transporter.
The Journal of biological chemistry 1997;272(30):18526-9.
1997: Hitoshi Endou; Yoshikatsu Kanai; N Utsunomiya-Tate; Makoto Hosoyamada
A novel Na(+)-dependent amino acid transporter with a high affinity to glutamine.
Contributions to nephrology 1997;121():31-6.
1996: Makoto Hosoyamada; M Obinata; M Suzuki; Hitoshi Endou
Cisplatin-induced toxicity in immortalized renal cell lines established from transgenic mice harboring temperature sensitive SV40 large T-antigen gene.
Archives of toxicology 1996;70(5):284-92.
1995: M Takeda; Makoto Hosoyamada; I Shirato; M Obinata; M Suzuki; Hitoshi Endou
Establishment of vasopressin-responsive early proximal tubular cell lines derived from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.
Biochemistry and molecular biology international 1995;37(3):507-15.
1994: T Sekine; Makoto Hosoyamada; A Haga-Mizuno; M Takeda; M Suzuki; M Obinata; Hitoshi Endou
Ammonia production in cell lines established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.
Contributions to nephrology 1994;110():98-102.