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Karl Hostetler
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47
Beadle, James
26
Aldern, Kathy
23
Gardner, Michael
19
Kern, Earl
13
Richman, Douglas
11
Freeman, William
11
Hartline, Caroll
11
Wan, William
10
Cheng, Lingyun
8
Bergeron-Lynn, Germaine
7
Ciesla, Stephanie
7
Kini, GD
7
Trahan, Julissa
6
Keith, Kathy
5
Korba, Brent
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All Publications
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2009: Botros Sanaa S; William Samia; Beadle James R; Valiaeva Nadejda; Hostetler Karl Y
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(s)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Antimicrobial agents and chemotherapy 2009;53(12):5284-7.
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2009: Morrey John D; Korba Brent E; Beadle James R; Wyles David L; Hostetler Karl Y
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Antimicrobial agents and chemotherapy 2009;53(7):2865-70.
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2009: Wyles David L; Kaihara Kelly A; Korba Brent E; Schooley Robert T; Beadle James R; Hostetler Karl Y
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Antimicrobial agents and chemotherapy 2009;53(6):2660-2.
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2009: Hostetler Karl Y
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.
Antiviral research 2009;82(2):A84-98.
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2008: Prichard Mark N; Hartline Caroll B; Harden Emma A; Daily Shannon L; Beadle James R; Valiaeva Nadejda; Kern Earl R; Hostetler Karl Y
Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2008;52(12):4326-30.
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2008: Quenelle Debra C; Collins Deborah J; Pettway Latisha R; Hartline Caroll B; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Antiviral research 2008;79(2):133-5.
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2008: Randhawa Parmjeet; Zemlicka Jiri; Sauerbrei Andreas; Meier Chris; Hostetler Karl Y; Beadle James R; Farasati Noush Afarin; Huang Yuchen; Bradley Matthews
Anti-BK virus activity of nucleoside analogs.
Antimicrobial agents and chemotherapy 2008;52(4):1519-21.
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2008: Magee Wendy C; Aldern Kathy A; Hostetler Karl Y; Evans David H
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
Antimicrobial agents and chemotherapy 2008;52(2):586-97.
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2007: Quenelle Debra C; Collins Deborah J; Herrod Bridgett P; Keith Kathy A; Trahan Julissa; Beadle James R; Hostetler Karl Y; Kern Earl R
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(11):3940-7.
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2007: Tammewar Ajay M; Cheng Lingyun; Hostetler Karl Y; Falkenstein Iryna; Beadle James R; Barron Erin C; Kozak Igor; Freeman William R
Intraocular properties of an alkoxyalkyl derivative of cyclic 9-(S)-(3-hydroxyl-2-phosphonomehoxypropyl) adenine, an intravitreally injectable anti-HCMV drug in rabbit and guinea pig.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(5):433-44.
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2007: Painter George R; Almond Merrick R; Trost Lawrence C; Lampert Bernhard M; Neyts Johan; De Clercq Erik; Korba Brent E; Aldern Kathy A; Beadle James R; Hostetler Karl Y
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Antimicrobial agents and chemotherapy 2007;51(10):3505-9.
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2007: Ruiz Jacqueline C; Beadle James R; Aldern Kathy A; Keith Kathy A; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Antiviral research 2007;75(1):87-90.
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2007: Dal Pozzo Fabiana; Andrei Graciela; Lebeau Ilya; Beadle James R; Hostetler Karl Y; De Clercq Erik; Snoeck Robert
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
Antiviral research 2007;75(1):52-7.
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2007: Hostetler Karl Y; Beadle James R; Trahan Julissa; Aldern Kathy A; Owens Gelita; Schriewer Jill; Melman Lora; Buller R Mark
Oral 1-O-octadecyl-2-O-benzyl-sn-glycero-3-cidofovir targets the lung and is effective against a lethal respiratory challenge with ectromelia virus in mice.
Antiviral research 2007;73(3):212-8.
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2007: Choo Hyunah; Beadle James R; Chong Youhoon; Trahan Julissa; Hostetler Karl Y
Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates.
Bioorganic & medicinal chemistry 2007;15(4):1771-9.
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2007: Choo Hyunah; Beadle James R; Kern Earl R; Prichard Mark N; Keith Kathy A; Hartline Caroll B; Trahan Julissa; Aldern Kathy A; Korba Brent E; Hostetler Karl Y
Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.
Antimicrobial agents and chemotherapy 2007;51(2):611-5.
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2006: Kornbluth Richard S; Smee Donald F; Sidwell Robert W; Snarsky Victoria; Evans David H; Hostetler Karl Y
Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.
Antimicrobial agents and chemotherapy 2006;50(12):4038-43.
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2006: Valiaeva Nadejda; Beadle James R; Aldern Kathy A; Trahan Julissa; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro.
Antiviral research 2006;72(1):10-9.
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2006: Hostetler Karl Y; Aldern Kathy A; Wan William B; Ciesla Stephanie L; Beadle James R
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
Antimicrobial agents and chemotherapy 2006;50(8):2857-9.
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2006: Lebeau Ilya; Andrei Graciela; Dal Pozzo Fabiana; Beadle James R; Hostetler Karl Y; De Clercq Erik; van den Oord Joost; Snoeck Robert
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.
Antimicrobial agents and chemotherapy 2006;50(7):2525-9.
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2006: Randhawa Parmjeet; Farasati Noush Afarin; Shapiro Ron; Hostetler Karl Y
Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.
Antimicrobial agents and chemotherapy 2006;50(4):1564-6.
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2006: Beadle James R; Wan William B; Ciesla Stephanie L; Keith Kathy A; Hartline Caroll; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Journal of medicinal chemistry 2006;49(6):2010-5.
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2006: Hostetler Karl Y; Rought Steffney; Aldern Kathy A; Trahan Julissa; Beadle James R; Corbeil Jacques
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.
Molecular cancer therapeutics 2006;5(1):156-9.
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2006: Ruiz Jacqueline C; Aldern Kathy A; Beadle James R; Hartline Caroll B; Kern Earl R; Hostetler Karl Y
Synthesis and antiviral evaluation of alkoxyalkyl esters of phosphonopropoxymethyl-guanine and phosphonopropoxymethyl-diaminopurine.
Antiviral chemistry & chemotherapy 2006;17(2):89-95.
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2005: Williams-Aziz Stephanie L; Hartline Caroll B; Harden Emma A; Daily Shannon L; Prichard Mark N; Kushner Nicole L; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro.
Antimicrobial agents and chemotherapy 2005;49(9):3724-33.
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2005: Magee Wendy C; Hostetler Karl Y; Evans David H
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
Antimicrobial agents and chemotherapy 2005;49(8):3153-62.
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2005: Lu Stephanie; Cheng Lingyun; Hostetler Karl Y; Koh Hyoung Jun; Beadle James R; Davidson Marie C; Freeman W R
Intraocular properties of hexadecyloxypropyl-cyclic-cidofovir in Guinea pigs.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005;21(3):205-9.
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2005: Wan William B; Beadle James R; Hartline Caroll; Kern Earl R; Ciesla Stephanie L; Valiaeva Nadejda; Hostetler Karl Y
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro.
Antimicrobial agents and chemotherapy 2005;49(2):656-62.
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2005: Hartline Caroll B; Gustin Kortney M; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
The Journal of infectious diseases 2005;191(3):396-9.
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2005: Smee Donald F; Wandersee Miles K; Bailey Kevin W; Hostetler Karl Y; Holy Antonin; Sidwell Robert W
Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.
Antiviral chemistry & chemotherapy 2005;16(3):203-11.
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2004: Cheng Lingyun; Hostetler Karl Y; Lee Jeffery; Koh Hyoung Jun; Beadle James R; Bessho Kenichiro; Toyoguchi Mitsuko; Aldern Kathy; Bovet Jean-Marc; Freeman William R
Characterization of a novel intraocular drug-delivery system using crystalline lipid antiviral prodrugs of ganciclovir and cyclic cidofovir.
Investigative ophthalmology & visual science 2004;45(11):4138-44.
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2004: Kern Earl R; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Quenelle Debra C
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(9):3516-22.
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2004: Painter George R; Hostetler Karl Y
Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.
Trends in biotechnology 2004;22(8):423-7.
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2004: Bidanset Deborah J; Beadle James R; Wan W Brad; Hostetler Karl Y; Kern Earl R
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.
The Journal of infectious diseases 2004;190(3):499-503.
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2004: Smee Donald F; Wong Min-Hui; Bailey Kevin W; Beadle James R; Hostetler Karl Y; Sidwell Robert W
Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.
International journal of antimicrobial agents 2004;23(5):430-7.
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2004: Keith Kathy A; Wan William B; Ciesla Stephanie L; Beadle James R; Hostetler Karl Y; Kern Earl R
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
Antimicrobial agents and chemotherapy 2004;48(5):1869-71.
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2004: Quenelle Debra C; Collins Deborah J; Wan W Brad; Beadle James R; Hostetler Karl Y; Kern Earl R
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.
Antimicrobial agents and chemotherapy 2004;48(2):404-12.
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2004: Buller R Mark; Owens Gelita; Schriewer Jill; Melman Lora; Beadle James R; Hostetler Karl Y
Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model.
Virology 2004;318(2):474-81.
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2003: Ciesla Stephanie L; Trahan Julissa; Wan W Brad; Beadle James R; Aldern Kathy A; Painter George R; Hostetler Karl Y
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.
Antiviral research 2003;59(3):163-71.
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2003: Cheng Lingyun; Hostetler Karl Y; Toyoguchi Mitsuko; Beadle James R; Rodanant Nuttawut; Gardner Michael F; Aldern Kathy A; Bergeron-Lynn Germaine; Freeman William R
Ganciclovir release rates in vitreous from different formulations of 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2003;19(2):161-9.
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2003: Aldern Kathy A; Ciesla Stephanie L; Winegarden Kristine L; Hostetler Karl Y
Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.
Molecular pharmacology 2003;63(3):678-81.
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2002: Beadle James R; Hartline Caroll; Aldern Kathy A; Rodriguez Natalie; Harden Emma; Kern Earl R; Hostetler Karl Y
Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro.
Antimicrobial agents and chemotherapy 2002;46(8):2381-6.
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2002: Kern Earl R; Hartline Caroll; Harden Emma; Keith Kathy; Rodriguez Natalie; Beadle James R; Hostetler Karl Y
Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir.
Antimicrobial agents and chemotherapy 2002;46(4):991-5.
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2002: Cheng Lingyun; Hostetler Karl Y; Chaidhawangul Sunan; Gardner Michael F; Beadle James R; Toyoguchi Mitsuko; Bergeron-Lynn Germaine; Freeman William R
Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir.
Investigative ophthalmology & visual science 2002;43(2):515-21.
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2001: Hammond J L; Koontz D L; Bazmi H Z; Beadle J R; Hostetler S E; Kini G D; Aldern K A; Richman D D; Hostetler K Y; Mellors J W
Alkylglycerol prodrugs of phosphonoformate are potent in vitro inhibitors of nucleoside-resistant human immunodeficiency virus type 1 and select for resistance mutations that suppress zidovudine resistance.
Antimicrobial agents and chemotherapy 2001;45(6):1621-8.
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2001: Hostetler K Y; Rybak R J; Beadle J R; Gardner M F; Aldern K A; Wright K N; Kern E R
In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections.
Antiviral chemistry & chemotherapy 2001;12(1):61-70.
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2000: Hostetler K Y; Beadle J R; Hornbuckle W E; Bellezza C A; Tochkov I A; Cote P J; Gerin J L; Korba B E; Tennant B C
Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy 2000;44(7):1964-9.
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2000: Hostetler K Y; Hammond J L; Kini G D; Hostetler S E; Beadle J R; Aldern K A; Chou T C; Richman D D; Mellors J W
In vitro anti-HIV-1 activity of sn-2-substituted 1-O-octadecyl-sn-glycero-3-phosphonoformate analogues and synergy with zidovudine.
Antiviral chemistry & chemotherapy 2000;11(3):213-9.
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2000: Cheng L; Hostetler K Y; Chaidhawangul S; Gardner M F; Beadle J R; Keefe K S; Bergeron-Lynn G; Severson G M; Soules K A; Mueller A J; Freeman W R
Intravitreal toxicology and duration of efficacy of a novel antiviral lipid prodrug of ganciclovir in liposome formulation.
Investigative ophthalmology & visual science 2000;41(6):1523-32.
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2000: Kern E R; Palmer J; Szczech G; Painter G; Hostetler K Y
Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):501-13.
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2000: Beadle J R; Kini G D; Aldern K A; Gardner M F; Wright K N; Rybak R J; Kern E R; Hostetler K Y
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):471-9.
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1999: Cheng L; Hostetler K Y; Gardner M F; Avila C P; Bergeron-Lynn G; Keefe K S; Beadle J R; Wiley C A; Freeman W R
Intravitreal toxicology and therapeutic efficacy of the carboxymethyl ester of the 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA-O-Me), a novel lipid antiviral prodrug for intraocular drug delivery.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 1999;15(4):363-77.
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1999: Cheng L; Hostetler K Y; Gardner M F; Avila C P; Bergeron-Lynn G; Keefe K S; Wiley C A; Freeman W R
Intravitreal toxicology in rabbits of two preparations of 1-O-octadecyl-sn-glycerol-3-phosphonoformate, a sustained-delivery anti-CMV drug.
Investigative ophthalmology & visual science 1999;40(7):1487-95.
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1999: Cheng L; Hostetler K Y; Gardner M F; Avila C P; Bergeron-Lynn G; Severson G M; Freeman W R
Intravitreal pharmacokinetics in rabbits of the foscarnet lipid prodrug: 1-O-octadecyl-sn-glycerol-3-phosphonoformate (ODG-PFA).
Current eye research 1999;18(3):161-7.
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1999: Cheng L; Hostetler K Y; Chaidhawangul S; Gardner M F; Ozerdem U; Bergeron-Lynn G; Mach-Hofacre B; Mueller A J; Severson G M; Freeman W R
Treatment of herpes retinitis in an animal model with a sustained delivery antiviral drug, liposomal 1-O-octadecyl-SN-glycerol-3-phosphonoformate.
Retina (Philadelphia, Pa.) 1999;19(4):325-31.
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1998: Beadle J R; Kini G D; Aldern K A; Gardner M F; Wright K N; Richman D D; Hostetler K Y
Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells.
Antiviral chemistry & chemotherapy 1998;9(1):33-40.
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1997: Kini G D; Beadle J R; Xie H; Aldern K A; Richman D D; Hostetler K Y
Alkoxy propane prodrugs of foscarnet: effect of alkyl chain length on in vitro antiviral activity in cells infected with HIV-1, HSV-1 and HCMV.
Antiviral research 1997;36(1):43-53.
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1997: Hostetler K Y; Beadle J R; Kini G D; Gardner M F; Wright K N; Wu T H; Korba B A
Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro.
Biochemical pharmacology 1997;53(12):1815-22.
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1997: Taskintuna I; Banker A S; Flores-Aguilar M; Bergeron-Lynn G; Aldern K A; Hostetler K Y; Freeman W R
Evaluation of a novel lipid prodrug for intraocular drug delivery: effect of acyclovir diphosphate dimyristoylglycerol in a rabbit model with herpes simplex virus-1 retinitis.
Retina (Philadelphia, Pa.) 1997;17(1):57-64.
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1996: Hostetler K Y; Kini G D; Beadle J R; Aldern K A; Gardner M F; Border R; Kumar R; Barshak L; Sridhar C N; Wheeler C J; Richman D D
Lipid prodrugs of phosphonoacids: greatly enhanced antiviral activity of 1-O-octadecyl-sn-glycero-3-phosphonoformate in HIV-1, HSV-1 and HCMV-infected cells, in vitro.
Antiviral research 1996;31(1-2):59-67.
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1996: Korba B A; Xie H; Wright K N; Hornbuckle W E; Gerin J L; Tennant B C; Hostetler K Y
Liver-targeted antiviral nucleosides: enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo.
Hepatology (Baltimore, Md.) 1996;23(5):958-63.
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1996: Reasor M J; McCloud C M; Beard T L; Ebert D C; Kacew S; Gardner M F; Aldern K A; Hostetler K Y
Comparative evaluation of amiodarone-induced phospholipidosis and drug accumulation in Fischer-344 and Sprague-Dawley rats.
Toxicology 1996;106(1-3):139-47.
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1995: Xie H; Voronkov M; Liotta D C; Korba B A; Schinazi R F; Richman D D; Hostetler K Y
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
Antiviral research 1995;28(2):113-20.
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1994: Hostetler K Y; Richman D D; Sridhar C N; Felgner P L; Felgner J; Ricci J; Gardner M F; Selleseth D W; Ellis M N
Phosphatidylazidothymidine and phosphatidyl-ddC: assessment of uptake in mouse lymphoid tissues and antiviral activities in human immunodeficiency virus-infected cells and in Rauscher leukemia virus-infected mice.
Antimicrobial agents and chemotherapy 1994;38(12):2792-7.
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1994: Hostetler K Y; Richman D D; Forssen E A; Selk L; Basava R; Gardner M F; Parker S; Basava C
Phospholipid prodrug inhibitors of the HIV protease. Antiviral activity and pharmacokinetics in rats.
Biochemical pharmacology 1994;48(7):1399-404.
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1994: Hostetler K Y; Korba B E; Sridhar C N; Gardner M F
Antiviral activity of phosphatidyl-dideoxycytidine in hepatitis B-infected cells and enhanced hepatic uptake in mice.
Antiviral research 1994;24(1):59-67.
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1994: van Wijk G M; Hostetler K Y; Kroneman E; Richman D D; Sridhar C N; Kumar R; van den Bosch H
Synthesis and antiviral activity of 3'-azido-3'-deoxythymidine triphosphate distearoylglycerol: a novel phospholipid conjugate of the anti-HIV agent AZT.
Chemistry and physics of lipids 1994;70(2):213-22.
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1993: Hostetler K Y; Parker S; Sridhar C N; Martin M J; Li J L; Stuhmiller L M; van Wijk G M; van den Bosch H; Gardner M F; Aldern K A
Acyclovir diphosphate dimyristoylglycerol: a phospholipid prodrug with activity against acyclovir-resistant herpes simplex virus.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11835-9.
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1993: Huterer S J; Hostetler K Y; Gardner M F; Wherrett J R
Lysosomal phosphatidylcholine: bis(monoacylglycero)phosphate acyltransferase: specificity for the sn-1 fatty acid of the donor and co-purification with phospholipase A1.
Biochimica et biophysica acta 1993;1167(2):204-10.
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1993: Schlame M; Brody S; Hostetler K Y
Mitochondrial cardiolipin in diverse eukaryotes. Comparison of biosynthetic reactions and molecular acyl species.
European journal of biochemistry / FEBS 1993;212(3):727-35.
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1992: van Wijk G M; Hostetler K Y; Suurmeijer C N; van den Bosch H
Synthesis, characterization and some properties of dideoxynucleoside analogs of cytidine diphosphate diacylglycerol.
Biochimica et biophysica acta 1992;1165(1):45-52.
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1992: Kumar R; Gardner M F; Richman D D; Hostetler K Y
Equal inhibition of HIV replication by stereoisomers of phosphatidyl-azidothymidine. Lack of stereospecificity of lysosomal phospholipase A1.
The Journal of biological chemistry 1992;267(28):20288-92.
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1992: Hostetler K Y; Richman D D; Carson D A; Stuhmiller L M; van Wijk G M; van den Bosch H
Greatly enhanced inhibition of human immunodeficiency virus type 1 replication in CEM and HT4-6C cells by 3'-deoxythymidine diphosphate dimyristoylglycerol, a lipid prodrug of 3'-deoxythymidine.
Antimicrobial agents and chemotherapy 1992;36(9):2025-9.
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1992: van Wijk G M; Hostetler K Y; van den Bosch H
Antiviral nucleoside diphosphate diglycerides: improved synthesis and facilitated purification.
Journal of lipid research 1992;33(8):1211-9.
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1992: van Wijk G M; Gadella T W; Wirtz K W; Hostetler K Y; van den Bosch H
Spontaneous and protein-mediated intermembrane transfer of the antiretroviral liponucleotide 3'-deoxythymidine diphosphate diglyceride.
Biochemistry 1992;31(25):5912-7.
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1992: Hostetler K Y; Huterer S J; Wherrett J R
Biosynthesis of bis(monoacylglycero)phosphate in liver and macrophage lysosomes.
Methods in enzymology 1992;209():104-10.
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1992: Schlame M; Hostetler K Y
Mammalian cardiolipin biosynthesis.
Methods in enzymology 1992;209():330-7.
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1991: Schlame M; Hostetler K Y
Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement.
The Journal of biological chemistry 1991;266(33):22398-403.
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1991: van Wijk G M; Hostetler K Y; Schlame M; van den Bosch H
Cytidine diphosphate diglyceride analogs of antiretroviral dideoxynucleosides: evidence for release of dideoxynucleoside-monophosphates by phospholipid biosynthetic enzymes in rat liver subcellular fractions.
Biochimica et biophysica acta 1991;1086(1):99-105.
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1991: Hostetler K Y
Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver.
Biochimica et biophysica acta 1991;1086(1):139-40.
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1991: van Wijk G M; Hostetler K Y; van den Bosch H
Lipid conjugates of antiretroviral agents: release of antiretroviral nucleoside monophosphates by a nucleoside diphosphate diglyceride hydrolase activity from rat liver mitochondria.
Biochimica et biophysica acta 1991;1084(3):307-10.
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1991: Hostetler K Y; Carson D A; Richman D D
Phosphatidylazidothymidine. Mechanism of antiretroviral action in CEM cells.
The Journal of biological chemistry 1991;266(18):11714-7.
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1991: Hostetler K Y; Vande Berg J; Aldern K A; Brophy G T
Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo.
Biochemical pharmacology 1991;41(6-7):1007-13.
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1991: Hostetler K Y; Gardner M F
Purification of rat kidney lysosomal phospholipase A1.
Methods in enzymology 1991;197():325-30.
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1991: Hostetler K Y; Gardner M F; Aldern K A
Assay of phospholipases C and D in presence of other lipid hydrolases.
Methods in enzymology 1991;197():125-34.
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1990: Hostetler K Y; Jellison E J
Inhibition of kidney lysosomal phospholipase A1 by aminoglycosides is a novel variant of substrate depletion inhibition.
The Journal of pharmacology and experimental therapeutics 1990;254(1):188-91.
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1990: Hostetler K Y; Stuhmiller L M; Lenting H B; van den Bosch H; Richman D D
Synthesis and antiretroviral activity of phospholipid analogs of azidothymidine and other antiviral nucleosides.
The Journal of biological chemistry 1990;265(11):6112-7.
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1989: Hostetler K Y; Jellison E J
Role of phospholipases in myocardial ischemia: effect of cardioprotective agents on the phospholipases A of heart cytosol and sarcoplasmic reticulum in vitro.
Molecular and cellular biochemistry 1989;88(1-2):77-82.
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1988: Trotz M; Hein L; Hostetler K Y
Solubilization and partial characterization of phospholipase A from rat heart sarcoplasmic reticulum.
Biochimica et biophysica acta 1988;962(2):248-57.
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1988: Hostetler K Y; Giordano J R; Jellison E J
In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone.
Biochimica et biophysica acta 1988;959(3):316-21.
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1987: Trotz M; Jellison E J; Hostetler K Y
Propranolol inhibition of the neutral phospholipases A of rat heart mitochondria, sarcoplasmic reticulum and cytosol.
Biochemical pharmacology 1987;36(24):4251-6.
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1986: Kubo M; Gardner M F; Hostetler K Y
Binding of propranolol and gentamicin to small unilamellar phospholipid vesicles. Contribution of ionic and hydrophobic forces.
Biochemical pharmacology 1986;35(21):3761-5.
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1986: Hostetler K Y; Gardner M F; Giordano J R
Purification of lysosomal phospholipase A and demonstration of proteins that inhibit phospholipase A in a lysosomal fraction from rat kidney cortex.
Biochemistry 1986;25(21):6456-61.
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1986: Nalbone G; Hostetler K Y; Leonardi J; Trotz M; Lafont H
Partial characterization of rat heart cytosolic phospholipase A1 and demonstration of essential sulfhydryl groups.
Biochimica et biophysica acta 1986;877(1):88-95.
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