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Gökhan Hotamisligil

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Haiming Cao; Baris C Ercal; Meric Erikci Ertunc; Masato Furuhashi; Karen Inouye; Jared R Mayers; Lisa M Rickey; Motohiro Sekiya; Gürol Tuncman; Ariel White; M Furkan Burak; Gökhan S Hotamisligil
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
Elisa Ghelfi; Gökhan S Hotamisligil; Chun G Lee; Matthew Terwelp; Chen-Wei Yu; Suzy A Comhair; Jack A Elias; Harun Elmasri; Serpil C Erzurum; Vineet Bhandari; Sule Cataltepe
Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma.
Ediz S Calay; Gökhan S Hotamisligil
Turning off the inflammatory, but not the metabolic, flames.

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2013: Haiming Cao; Baris C Ercal; Meric Erikci Ertunc; Masato Furuhashi; Karen Inouye; Jared R Mayers; Lisa M Rickey; Motohiro Sekiya; Gürol Tuncman; Ariel White; M Furkan Burak; Gökhan S Hotamisligil
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
Cell metabolism 2013;17(5):768-78.
2013: Elisa Ghelfi; Gökhan S Hotamisligil; Chun G Lee; Matthew Terwelp; Chen-Wei Yu; Suzy A Comhair; Jack A Elias; Harun Elmasri; Serpil C Erzurum; Vineet Bhandari; Sule Cataltepe
Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model: implications for asthma.
The American journal of pathology 2013;182(4):1425-33.
2013: Ediz S Calay; Gökhan S Hotamisligil
Turning off the inflammatory, but not the metabolic, flames.
Nature medicine 2013;19(3):265-7.
2013: Abdullah Yalcin; Gökhan S Hotamisligil
Impact of ER protein homeostasis on metabolism.
Diabetes 2013;62(3):691-3.
2013: Mustafa Yilmaz; Gökhan S Hotamisligil
Damned if you do, damned if you don't: the conundrum of adipose tissue vascularization.
Cell metabolism 2013;17(1):7-9.
2012: Ben Lu; Peter Lundbäck; Takahisa Nakamura; Peder S Olofsson; Jesse Roth; Yiting Tang; Jenny P-Y Ting; Ulf Andersson; Daniel J Antoine; Sangeeta S Chavan; Helena Erlandsson Harris; Gökhan S Hotamisligil; Karen Inouye; Thomas Kalb; Jianhua Li; Sergio I Valdes-Ferrer; Haichao Wang; Huan Yang; Yongrui Zou; Kevin J Tracey
Novel role of PKR in inflammasome activation and HMGB1 release.
Nature 2012;488(7413):670-4.
2012: Steven M Watkins; Gökhan S Hotamisligil
Promoting atherosclerosis in type 1 diabetes through the selective activation of arachidonic acid and PGE(2) production.
Circulation research 2012;111(4):394-6.
2012: Suneng Fu; Alfredo Gimenez-Cassina; Joshua Blanco; Nika N Danial; Jason Fan; Steve M Watkins; Gökhan S Hotamisligil
Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.
PLoS genetics 2012;8(8):e1002902.
2012: Henrik Ten Freyhaus; Sara N Vallerie; Abdullah Yalcin; Ling Yang; Ediz S Calay; Zerrin Z Calay; Fahri Saatcioglu; Gökhan S Hotamisligil
Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis.
Cell metabolism 2012;16(1):81-9.
2012: Daiju Fukuda; Cem Z Gorgun; Gökhan S Hotamisligil; Victor Kotelianski; Tatiana I Novobrantseva; Filip K Swirski; Ralph Weissleder; Hideo Yagita; Hiroyuki Yamazaki; Elena Aikawa; Jon C Aster; Aleksey Chudnovskiy; Kevin Croce; Masanori Aikawa
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(27):E1868-77.
2012: Suneng Fu; Steven M Watkins; Gökhan S Hotamisligil
The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling.
Cell metabolism 2012;15(5):623-34.
2012: Lars P Bechmann; Guido Gerken; Rebekka A Hannivoort; Gökhan S Hotamisligil; Michael Trauner; Ali Canbay
The interaction of hepatic lipid and glucose metabolism in liver diseases.
Journal of hepatology 2012;56(4):952-64.
2012: Raymond S Oh; Wen-Chi Pan; Abdullah Yalcin; Hong Zhang; David C Christiani; Tomás R Guilarte; Gökhan S Hotamisligil; Quan Lu
Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress.
The Journal of biological chemistry 2012;287(8):6025-34.
2011: Jessica L Yecies; Hui H Zhang; Suchithra Menon; Derek Yecies; Cem Gorgun; Gökhan S Hotamisligil; David J Kwiatkowski; Chih-Hao Lee; Alex I Lipovsky; Sihao Liu; Brendan D Manning
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
Cell metabolism 2011;14(1):21-32.
2011: Vladimir R Babaev; Robert P Runner; Daping Fan; Lei Ding; Youmin Zhang; Huan Tao; Ebru Erbay; Cem Z Görgün; Sergio Fazio; Gökhan S Hotamisligil; MacRae F Linton
Macrophage Mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(6):1283-90.
2011: Suneng Fu; Ling Yang; Ping Li; Oliver Hofmann; Lee Dicker; Winston Hide; Xihong Lin; Steven M Watkins; Alexander R Ivanov; Gökhan S Hotamisligil
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity.
Nature 2011;473(7348):528-31.
2011: Ann-Hwee Lee; Keely Heidtman; Gökhan S Hotamisligil; Laurie H Glimcher
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(21):8885-90.
2011: Tiffany Horng; Gökhan S Hotamisligil
Linking the inflammasome to obesity-related disease.
Nature medicine 2011;17(2):164-5.
2011: Masato Furuhashi; Manabu Hayashi; Gökhan S Hotamisligil; Shutaro Ishimura; Takahiro Nishitani; Hideki Ota; Kazuaki Shimamoto; Marenao Tanaka; Hideaki Yoshida; Tetsuji Miura
Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease.
PloS one 2011;6(11):e27356.
2011: Kristin M Nieman; Carla V Penicka; Marcus E Peter; Iris L Romero; S Diane Yamada; Marion R Zillhardt; Rebecca Buell-Gutbrod; Mark S Carey; Katja Gwin; Gökhan S Hotamisligil; Hilary A Kenny; Andras Ladanyi; Gordon B Mills; Ernst Lengyel
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nature medicine 2011;17(11):1498-503.
2011: Margaret F Gregor; Gökhan S Hotamisligil
Inflammatory mechanisms in obesity.
Annual review of immunology 2011;29():415-45.
2010: Dariush Mozaffarian; Haiming Cao; Irena B King; Rozenn N Lemaitre; Xiaoling Song; David S Siscovick; Gökhan S Hotamisligil
Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study.
Annals of internal medicine 2010;153(12):790-9.
2010: Sara N Vallerie; Gökhan S Hotamisligil
The role of JNK proteins in metabolism.
Science translational medicine 2010;2(60):60rv5.
2010: Dariush Mozaffarian; Haiming Cao; Irena B King; Rozenn N Lemaitre; Xiaoling Song; David S Siscovick; Gökhan S Hotamisligil
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
The American journal of clinical nutrition 2010;92(6):1350-8.
2010: Sarah Hummasti; Gökhan S Hotamisligil
Endoplasmic reticulum stress and inflammation in obesity and diabetes.
Circulation research 2010;107(5):579-91.
2010: Marleen Kars; Ling Yang; Margaret F Gregor; B Selma Mohammed; Terri A Pietka; Brian N Finck; Bruce W Patterson; Jay D Horton; Bettina Mittendorfer; Gökhan S Hotamisligil; Samuel Klein
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.
Diabetes 2010;59(8):1899-905.
2010: Ling Yang; Ping Li; Suneng Fu; Ediz S Calay; Gökhan S Hotamisligil
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.
Cell metabolism 2010;11(6):467-78.
2010: Ping Li; Gökhan S Hotamisligil
Metabolism: Host and microbes in a pickle.
Nature 2010;464(7293):1287-8.
2010: Gökhan S Hotamisligil
Endoplasmic reticulum stress and atherosclerosis.
Nature medicine 2010;16(4):396-9.
2010: Gökhan S Hotamisligil
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.
Cell 2010;140(6):900-17.
2010: Takahisa Nakamura; Masato Furuhashi; Ping Li; Haiming Cao; Gurol Tuncman; Nahum Sonenberg; Cem Z Gorgun; Gökhan S Hotamisligil
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.
Cell 2010;140(3):338-48.
2009: Ebru Erbay; Vladimir R Babaev; Jared R Mayers; Liza Hayes; Khanichi N Charles; Melinda E Snitow; Sergio Fazio; Michelle M Wiest; Steven M Watkins; MacRae F Linton; Gökhan S Hotamisligil
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.
Nature medicine 2009;15(12):1383-91.
2009: Jian Liu; Adeline Divoux; Jiusong Sun; Jie Zhang; Karine Clément; Jonathan N Glickman; Galina K Sukhova; Paul J Wolters; Juan Du; Cem Z Gorgun; Alessandro Doria; Peter Libby; Richard S Blumberg; Barbara B Kahn; Gökhan S Hotamisligil; Guo-Ping Shi
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.
Nature medicine 2009;15(8):940-5.
2009: Margaret F Gregor; Ling Yang; Elisa Fabbrini; B Selma Mohammed; J Christopher Eagon; Gökhan S Hotamisligil; Samuel Klein
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.
Diabetes 2009;58(3):693-700.
2008: Gökhan S Hotamisligil; Ebru Erbay
Nutrient sensing and inflammation in metabolic diseases.
Nature reviews. Immunology 2008;8(12):923-34.
2008: Ling Yang; Gökhan S Hotamisligil
Stressing the brain, fattening the body.
Cell 2008;135(1):20-2.
2008: Haiming Cao; Kristin Gerhold; Jared R Mayers; Michelle M Wiest; Steven M Watkins; Gökhan S Hotamisligil
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.
Cell 2008;134(6):933-44.
2008: Masato Furuhashi; Raquel Fucho; Cem Z Görgün; Gürol Tuncman; Haiming Cao; Gökhan S Hotamisligil
Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.
The Journal of clinical investigation 2008;118(7):2640-50.
2008: Masato Furuhashi; Gökhan S Hotamisligil
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.
Nature reviews. Drug discovery 2008;7(6):489-503.
2008: Umut Ozcan; Lale Ozcan; Erkan Yilmaz; Katrin Düvel; Mustafa Sahin; Brendan D Manning; Gökhan S Hotamisligil
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
Molecular cell 2008;29(5):541-51.
2008: Sara N Vallerie; Masato Furuhashi; Raquel Fucho; Gökhan S Hotamisligil
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity.
PloS one 2008;3(9):e3151.
2007: Ebru Erbay; Haiming Cao; Gökhan S Hotamisligil
Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome.
Current atherosclerosis reports 2007;9(3):222-9.
2007: Margaret F Gregor; Gökhan S Hotamisligil
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
Journal of lipid research 2007;48(9):1905-14.
2007: Simin Liu; Lesley Tinker; Yiqing Song; Nader Rifai; Denise E Bonds; Nancy R Cook; Gerardo Heiss; Barbara V Howard; Gökhan S Hotamisligil; Frank B Hu; Lewis H Kuller; JoAnn E Manson
A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.
Archives of internal medicine 2007;167(15):1676-85.
2007: Joseph M Reynolds; Qiaohong Liu; Katherine C Brittingham; Yawei Liu; Michael Gruenthal; Cem Z Gorgun; Gökhan S Hotamisligil; Robert D Stout; Jill Suttles
Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):313-21.
2007: Yiqing Song; JoAnn E Manson; Lesley Tinker; Nader Rifai; Nancy R Cook; Frank B Hu; Gökhan S Hotamisligil; Paul M Ridker; Beatriz L Rodriguez; Karen L Margolis; Albert Oberman; Simin Liu
Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women.
Diabetes 2007;56(7):1898-904.
2007: Masato Furuhashi; Gürol Tuncman; Cem Z Görgün; Liza Hayes; Genichi Atsumi; Eric Vaillancourt; Keita Kono; Vladimir R Babaev; Sergio Fazio; MacRae F Linton; Richard Sulsky; Jeffrey A Robl; Rex A Parker; Gökhan S Hotamisligil
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.
Nature 2007;447(7147):959-65.
2007: Kathryn E Wellen; Raquel Fucho; Margaret F Gregor; Masato Furuhashi; Carlos Morgan; Torstein Lindstad; Eric Vaillancourt; Cem Z Gorgun; Fahri Saatcioglu; Gökhan S Hotamisligil
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.
Cell 2007;129(3):537-48.
2007: Qiang Tong; Gökhan S Hotamisligil
Developmental biology: cell fate in the mammary gland.
Nature 2007;445(7129):724-6.
2007: Gökhan S Hotamisligil
Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes.
Novartis Foundation symposium 2007;286():86-94; discussion 94-8, 162-3, 196-203.
2006: Gökhan S Hotamisligil
Inflammation and metabolic disorders.
Nature 2006;444(7121):860-7.
2006: Gregory R Steinberg; Belinda J Michell; Bryce J W van Denderen; Matthew J Watt; Andrew L Carey; Barbara C Fam; Sofianos Andrikopoulos; Joseph Proietto; Cem Z Görgün; David Carling; Gökhan S Hotamisligil; Mark A Febbraio; Thomas W H Kay; Bruce E Kemp
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.
Cell metabolism 2006;4(6):465-74.
2006: Michael S Rolph; Timothy Young; Bennett O V Shum; Cem Z Gorgun; Carsten Schmitz-Peiffer; Ian A Ramshaw; Gökhan S Hotamisligil; Charles R Mackay
Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7794-801.
2006: Herbert Tilg; Gökhan S Hotamisligil
Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance.
Gastroenterology 2006;131(3):934-45.
2006: Umut Ozcan; Erkan Yilmaz; Lale Ozcan; Masato Furuhashi; Eric Vaillancourt; Ross O Smith; Cem Z Görgün; Gökhan S Hotamisligil
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Science (New York, N.Y.) 2006;313(5790):1137-40.
2006: Kendra K Bence; Mirela Delibegovic; Bingzhong Xue; Cem Z Gorgun; Gökhan S Hotamisligil; Benjamin G Neel; Barbara B Kahn
Neuronal PTP1B regulates body weight, adiposity and leptin action.
Nature medicine 2006;12(8):917-24.
2006: Bennett O V Shum; Charles R Mackay; Cem Z Gorgun; Melinda J Frost; Rakesh K Kumar; Gökhan S Hotamisligil; Michael S Rolph
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation.
The Journal of clinical investigation 2006;116(8):2183-2192.
2006: Gürol Tuncman; Jiro Hirosumi; Giovanni Solinas; Lufen Chang; Michael Karin; Gökhan S Hotamisligil
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10741-6.
2006: Haiming Cao; Kazuhisa Maeda; Cem Z Gorgun; Hyo-Jeong Kim; So-Young Park; Gerald I Shulman; Jason K Kim; Gökhan S Hotamisligil
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.
Diabetes 2006;55(7):1915-22.
2006: Gürol Tuncman; E Erbay; X Hom; Immaculata DeVivo; HANNIA CAMPOS; E B Rimm; Gökhan S Hotamisligil
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6970-5.
2006: Jean-louis Sankale; Qiang Tong; Colleen Hadigan; Guo Tan; Steven K Grinspoon; Phyllis J Kanki; Gökhan S Hotamisligil
Regulation of adiponectin in adipocytes upon exposure to HIV-1.
HIV medicine 2006;7(4):268-74.
2006: Julia Baumgartl; Stephanie Baudler; Maximilian Scherner; Vladimir Babaev; Liza Hayes; Jill Suttles; Marcia McDuffie; Kazuyuki Tobe; Takashi Kadowaki; Sergio Fazio; C Ronald Kahn; Gökhan S Hotamisligil; Wilhelm Krone; MacRae F Linton; Jens C Brüning
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
Cell metabolism 2006;3(4):247-56.
2006: Jaap G Neels; Manjula Pandey; Gökhan S Hotamisligil; Fahumiya Samad
Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice.
The American journal of pathology 2006;168(2):435-44.
2005: Gökhan S Hotamisligil
Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.
Diabetes 2005;54 Suppl 2():S73-8.
2005: Liza Hayes; Gökhan S Hotamisligil
The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis.
Current opinion in lipidology 2005;16(5):543-8.
2005: Judy Tsai; Qiang Tong; Guo Tan; Aaron N Chang; Stuart H Orkin; Gökhan S Hotamisligil
The transcription factor GATA2 regulates differentiation of brown adipocytes.
EMBO reports 2005;6(9):879-84.
2005: Kathryn E Wellen; Gökhan S Hotamisligil
Inflammation, stress, and diabetes.
The Journal of clinical investigation 2005;115(5):1111-9.
2005: Tobias Pischon; Cynthia J Girman; Nader Rifai; Gökhan S Hotamisligil; Eric B Rimm
Association between dietary factors and plasma adiponectin concentrations in men.
The American journal of clinical nutrition 2005;81(4):780-6.
2005: Liza Hayes; Katherine C Brittingham; Joseph M Reynolds; Jill Suttles; Gökhan S Hotamisligil
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.
The Journal of biological chemistry 2005;280(13):12888-95.
2005: Kazuhisa Maeda; Haiming Cao; Keita Kono; Cem Z Gorgun; Masato Furuhashi; Teo Uysal; Qiong Cao; Genichi Atsumi; Harry Malone; Bala Krishnan; Yasuhiko Minokoshi; Barbara B Kahn; Rex A Parker; Gökhan S Hotamisligil
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
Cell metabolism 2005;1(2):107-19.
2005: Qiang Tong; Judy Tsai; Guo Tan; Gokhan Dalgin; Gökhan S Hotamisligil
Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.
Molecular and cellular biology 2005;25(2):706-15.
2004: Umut Ozcan; Qiong Cao; Erkan Yilmaz; Ann-Hwee Lee; Neal N Iwakoshi; Esra Ozdelen; Gürol Tuncman; Cem Z Görgün; Laurie H Glimcher; Gökhan S Hotamisligil
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Science (New York, N.Y.) 2004;306(5695):457-61.
2004: Jeffrey B Boord; Kazuhisa Maeda; Liza Hayes; Vladimir R Babaev; Sergio Fazio; MacRae F Linton; Gökhan S Hotamisligil
Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice.
Circulation 2004;110(11):1492-8.
2004: Liza Hayes; Gökhan S Hotamisligil
Fatty acid binding proteins--the evolutionary crossroads of inflammatory and metabolic responses.
The Journal of nutrition 2004;134(9):2464S-2468S.
2004: Kathryn E Wellen; Teo Uysal; Sarah Wiesbrock; Qing Yang; Hong Chen; Gökhan S Hotamisligil
Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.
Endocrinology 2004;145(5):2214-20.
2004: Tobias Pischon; Cynthia J Girman; Gökhan S Hotamisligil; Nader Rifai; Frank B Hu; Eric B Rimm
Plasma adiponectin levels and risk of myocardial infarction in men.
JAMA : the journal of the American Medical Association 2004;291(14):1730-7.
2003: Gökhan S Hotamisligil
Inflammatory pathways and insulin action.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27 Suppl 3():S53-5.
2003: Kathryn E Wellen; Gökhan S Hotamisligil
Obesity-induced inflammatory changes in adipose tissue.
The Journal of clinical investigation 2003;112(12):1785-8.
2003: Qiang Tong; Judy Tsai; Gökhan S Hotamisligil
GATA transcription factors and fat cell formation.
Drug news & perspectives 2003;16(9):585-8.
2003: Tobias Pischon; Susan E Hankinson; Gökhan S Hotamisligil; Nader Rifai; Eric B Rimm
Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers.
Obesity research 2003;11(9):1055-64.
2003: Tobias Pischon; Susan E Hankinson; Gökhan S Hotamisligil; Nader Rifai; Walter C Willett; Eric B Rimm
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women.
Circulation 2003;108(2):155-60.
2003: Qiang Tong; Jean-louis Sankale; Colleen Hadigan; Guo Tan; Eric S Rosenberg; Phyllis J Kanki; Steven K Grinspoon; Gökhan S Hotamisligil
Regulation of adiponectin in human immunodeficiency virus-infected patients: relationship to body composition and metabolic indices.
The Journal of clinical endocrinology and metabolism 2003;88(4):1559-64.
2003: Tobias Pischon; Gökhan S Hotamisligil; Eric B Rimm
Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year.
Clinical chemistry 2003;49(4):650-2.
2003: Manjula Pandey; Gürol Tuncman; Gökhan S Hotamisligil; Fahumiya Samad
Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1.
The American journal of pathology 2003;162(3):933-41.
2003: Kazuhisa Maeda; Teo Uysal; Liza Hayes; Cem Z Görgün; Genichi Atsumi; Rex A Parker; Jens C Brüning; Ann Vogel Hertzel; David A Bernlohr; Gökhan S Hotamisligil
Role of the fatty acid binding protein mal1 in obesity and insulin resistance.
Diabetes 2003;52(2):300-7.
2003: Gökhan S Hotamisligil
The irresistible biology of resistin.
The Journal of clinical investigation 2003;111(2):173-4.
2002: Jiro Hirosumi; Gürol Tuncman; Lufen Chang; Cem Z Görgün; Teo Uysal; Kazuhisa Maeda; Michael Karin; Gökhan S Hotamisligil
A central role for JNK in obesity and insulin resistance.
Nature 2002;420(6913):333-6.
2002: Jeffrey B Boord; Kazuhisa Maeda; Liza Hayes; Vladimir R Babaev; Sergio Fazio; MacRae F Linton; Gökhan S Hotamisligil
Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(10):1686-91.
2002: Haiyan Xu; Teo Uysal; J David Becherer; Peter Arner; Gökhan S Hotamisligil
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity.
Diabetes 2002;51(6):1876-83.
2002: Haiyan Xu; Jiro Hirosumi; Teo Uysal; A Deniz Guler; Gökhan S Hotamisligil
Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance.
Endocrinology 2002;143(4):1502-11.
2002: Chiara Chiellini; Anna Bertacca; Silvia E Novelli; Cem Z Görgün; Annamaria Ciccarone; Antonio Giordano; Haiyan Xu; Alexander Soukas; Mario Costa; Daniele Gandini; Roberto Dimitri; Pietro Bottone; Paolo Cecchetti; Ennia Pardini; Lucia Perego; Renzo Navalesi; Franco Folli; Luca Benzi; Saverio Cinti; Jeffrey M Friedman; Gökhan S Hotamisligil; Margherita Maffei
Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.
Journal of cellular physiology 2002;190(2):251-8.
2001: Haiyan Xu; Gökhan S Hotamisligil
Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation.
FEBS letters 2001;506(2):97-102.
2001: James M Way; Cem Z Görgün; Q Tong; Teo Uysal; K K Brown; W W Harrington; W R Oliver; Timothy M Willson; Steven A Kliewer; Gökhan S Hotamisligil
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
The Journal of biological chemistry 2001;276(28):25651-3.
2001: Liza Hayes; Jeffrey B Boord; Kazuhisa Maeda; Vladimir R Babaev; Teo Uysal; M A Morgan; Rex A Parker; Jill Suttles; Sergio Fazio; Gökhan S Hotamisligil; MacRae F Linton
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
Nature medicine 2001;7(6):699-705.
2001: Nain-Feng Chu; Donna Spiegelman; J Yu; Nader Rifai; Gökhan S Hotamisligil; Eric B Rimm
Plasma leptin concentrations and four-year weight gain among US men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(3):346-53.
2001: Nain-Feng Chu; M J Stampfer; Donna Spiegelman; Nader Rifai; Gökhan S Hotamisligil; Eric B Rimm
Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(1):106-14.
2000: Qiang Tong; Gokhan Dalgin; H Xu; Chao-Nan Ting; Jeffrey M Leiden; Gökhan S Hotamisligil
Function of GATA transcription factors in preadipocyte-adipocyte transition.
Science (New York, N.Y.) 2000;290(5489):134-8.
2000: Nain-Feng Chu; Donna Spiegelman; Nader Rifai; Gökhan S Hotamisligil; Eric B Rimm
Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(9):1085-92.
2000: Teo Uysal; L Scheja; Sarah Wiesbrock; S Bonner-Weir; Gökhan S Hotamisligil
Improved glucose and lipid metabolism in genetically obese mice lacking aP2.
Endocrinology 2000;141(9):3388-96.
2000: Enzo Nisoli; Luca Briscini; Antonio Giordano; Cristina Tonello; Sarah Wiesbrock; Teo Uysal; S Cinti; Michele O Carruba; Gökhan S Hotamisligil
Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8033-8.
2000: Jaswinder Sethi; Haiyan Xu; Teo Uysal; Sarah Wiesbrock; L Scheja; Gökhan S Hotamisligil
Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors.
FEBS letters 2000;469(1):77-82.
1999: L Scheja; Liza Hayes; Teo Uysal; Sarah Wiesbrock; D R Shimshek; D S Meyers; M Morgan; Rex A Parker; Gökhan S Hotamisligil
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
Diabetes 1999;48(10):1987-94.
1999: Haiyan Xu; Jaswinder Sethi; Gökhan S Hotamisligil
Transmembrane tumor necrosis factor (TNF)-alpha inhibits adipocyte differentiation by selectively activating TNF receptor 1.
The Journal of biological chemistry 1999;274(37):26287-95.
1999: Fahumiya Samad; Teo Uysal; Sarah Wiesbrock; Manjula Pandey; Gökhan S Hotamisligil; David J Loskutoff
Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):6902-7.
1999: Jaswinder Sethi; Gökhan S Hotamisligil
The role of TNF alpha in adipocyte metabolism.
Seminars in cell & developmental biology 1999;10(1):19-29.
1999: Gökhan S Hotamisligil
Mechanisms of TNF-alpha-induced insulin resistance.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(2):119-25.
1998: Teo Uysal; Sarah Wiesbrock; Gökhan S Hotamisligil
Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity.
Endocrinology 1998;139(12):4832-8.
1997: Todd Kirchgessner; Teo Uysal; Sarah Wiesbrock; M W Marino; Gökhan S Hotamisligil
Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.
The Journal of clinical investigation 1997;100(11):2777-82.
1997: Teo Uysal; Sarah Wiesbrock; M W Marino; Gökhan S Hotamisligil
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function.
Nature 1997;389(6651):610-4.
1996: Gökhan S Hotamisligil; R S Johnson; Robert Distel; R Ellis; V E Papaioannou; Bruce M Spiegelman
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.
Science (New York, N.Y.) 1996;274(5291):1377-9.