Nigishi Hotta

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Kanai Akio; Kawamura Takahiko; Umemura Tositaka; Nagashima Masahito; Nakamura Nobuhisa; Nakayama Mikihiro; Sano Takahisa; Nakashima Eitaro; Hamada Yoji; Nakamura Jiro; Hotta Nigishi
Association between future events of brain infarction and soluble levels of intercellular adhesion molecule-1 and C-reactive protein in patients with type 2 diabetes mellitus.
Yonaha Osamu; Matsubara Tatsuaki; Naruse Keiko; Ishii Hideki; Murohara Toyoaki; Nakamura Jiro; Amano Tetsuya; Hotta Nigishi
Effects of reduced coronary flow reserve on left ventricular function in type 2 diabetes.
Umemura Toshitaka; Kawamura Takahiko; Sakakibara Toshimasa; Kanai Akio; Sano Takahisa; Hotta Nigishi; Sobue Gen
Association of soluble adhesion molecule and C-reactive protein levels with silent brain infarction in patients with and without type 2 diabetes.

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2008: Kanai Akio; Kawamura Takahiko; Umemura Tositaka; Nagashima Masahito; Nakamura Nobuhisa; Nakayama Mikihiro; Sano Takahisa; Nakashima Eitaro; Hamada Yoji; Nakamura Jiro; Hotta Nigishi
Association between future events of brain infarction and soluble levels of intercellular adhesion molecule-1 and C-reactive protein in patients with type 2 diabetes mellitus.
Diabetes research and clinical practice 2008;82(2):157-64.
2008: Yonaha Osamu; Matsubara Tatsuaki; Naruse Keiko; Ishii Hideki; Murohara Toyoaki; Nakamura Jiro; Amano Tetsuya; Hotta Nigishi
Effects of reduced coronary flow reserve on left ventricular function in type 2 diabetes.
Diabetes research and clinical practice 2008;82(1):98-103.
2008: Umemura Toshitaka; Kawamura Takahiko; Sakakibara Toshimasa; Kanai Akio; Sano Takahisa; Hotta Nigishi; Sobue Gen
Association of soluble adhesion molecule and C-reactive protein levels with silent brain infarction in patients with and without type 2 diabetes.
Current neurovascular research 2008;5(2):106-11.
2008: Amano Tetsuya; Matsubara Tatsuaki; Uetani Tadayuki; Nanki Michio; Marui Nobuyuki; Kato Masataka; Yoshida Tomohiro; Arai Kosuke; Yokoi Kiminobu; Ando Hirohiko; Kumagai Soichiro; Ishii Hideki; Izawa Hideo; Hotta Nigishi; Murohara Toyoaki
Abnormal glucose regulation is associated with lipid-rich coronary plaque: relationship to insulin resistance.
JACC. Cardiovascular imaging 2008;1(1):39-45.
2007: Matsuoka Kempei; Sakamoto Nobuo; Akanuma Yasuo; Hotta Nigishi; Shichiri Motoaki; Toyota Takayoshi; Oka Yoshitomo; Kawamori Ryuzo; Shigeta Yukio;
A long-term effect of epalrestat on motor conduction velocity of diabetic patients: ARI-Diabetes Complications Trial (ADCT).
Diabetes research and clinical practice 2007;77 Suppl 1():S263-8.
2006: Hotta Nigishi; Akanuma Yasuo; Kawamori Ryuzo; Matsuoka Kempei; Oka Yoshitomo; Shichiri Motoaki; Toyota Takayoshi; Nakashima Mitsuyoshi; Yoshimura Isao; Sakamoto Nobuo; Shigeta Yukio
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial.
Diabetes care 2006;29(7):1538-44.
2006: Kawamura Takahiko; Umemura Toshitaka; Kanai Akio; Nagashima Masahito; Nakamura Nobuhisa; Uno Tomoko; Nakayama Mikihiro; Sano Takahisa; Hamada Yoji; Nakamura Jiro; Hotta Nigishi
Soluble adhesion molecules and C-reactive protein in the progression of silent cerebral infarction in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2006;55(4):461-6.
2005: Hamada Yoji; Nakashima Eitaro; Naruse Keiko; Nakae Mika; Naiki Mitsuru; Fujisawa Hiroki; Oiso Yutaka; Hotta Nigishi; Nakamura Jiro
A copper chelating agent suppresses carbonyl stress in diabetic rat lenses.
Journal of diabetes and its complications 2005;19(6):328-34.
2005: Hotta Nigishi
[Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 6():127-35.
2005: Hotta Nigishi
[Diabetic neuropathy]
Nippon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 2():630-6.
2004: Li Weiguo; Hamada Yoji; Nakashima Eitaro; Naruse Keiko; Kamiya Hideki; Akiyama Noboru; Hirooka Hiroko; Takahashi Naoki; Horiuchi Seikoh; Hotta Nigishi; Oiso Yutaka; Nakamura Jiro
Suppression of 3-deoxyglucosone and heparin-binding epidermal growth factor-like growth factor mRNA expression by an aldose reductase inhibitor in rat vascular smooth muscle cells.
Biochemical and biophysical research communications 2004;314(2):370-6.
2004: Hotta Nigishi; Yasuda Keigo; Sumita Yasuhiro; Sano Takahisa; Kakuta Hironobu; Nagashima Makoto; Hayashi Yoshinari; Yamamoto Masahiro; Wakao Takaaki; Okuyama Makio; Kobayashi Masato; Mori Kouichi
Effects of a Novel Aldose Reductase Inhibitor, Fidarestat (SNK-860), on Vibration Perception Threshold and Subjective Symptoms in Patients with Diabetic Polyneuropathy : An Open-Label Pilot Study.
Clinical drug investigation 2004;24(11):671-80.
2003: Miwa Kazuma; Nakamura Jiro; Hamada Yoji; Naruse Keiko; Nakashima Eitaro; Kato Koichi; Kasuya Yasuhide; Yasuda Yutaka; Kamiya Hideki; Hotta Nigishi
The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes.
Diabetes research and clinical practice 2003;60(1):1-9.
2003: Kamiya Hideki; Nakamura Jiro; Hamada Yoji; Nakashima Eitaro; Naruse Keiko; Kato Koichi; Yasuda Yutaka; Hotta Nigishi
Polyol pathway and protein kinase C activity of rat Schwannoma cells.
Diabetes/metabolism research and reviews 2003;19(2):131-9.
2002: Hotta Nigishi
[Risk factors for diabetic complications: Abnormality of polyol metabolism]
Nippon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 10():60-6.
2002: Nakamura Jiro; Hamada Yoji; Chaya Sadao; Nakashima Eitaro; Naruse Keiko; Kato Koichi; Yasuda Yutaka; Kamiya Hideki; Sakakibara Fumihiko; Koh Naoki; Hotta Nigishi
Transition metals and polyol pathway in the development of diabetic neuropathy in rats.
Diabetes/metabolism research and reviews 2002;18(5):395-402.
2002: Naruse Tomohiko; Yuzawa Yukio; Akahori Toshiyuki; Mizuno Masashi; Maruyama Shoji; Kannagi Reiji; Hotta Nigishi; Matsuo Seiichi
P-selectin-dependent macrophage migration into the tubulointerstitium in unilateral ureteral obstruction.
Kidney international 2002;62(1):94-105.
2002: Kondo K; Matsubara T; Nakamura J; Hotta N
Characteristic patterns of circadian variation in plasma catecholamine levels, blood pressure and heart rate variability in Type 2 diabetic patients.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(5):359-65.
2002: Hotta Nigishi
[Progress in studies of diabetes mellitus in the last 100 years in Japan]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(4):1100-4.
2002: Yoshida Seiji; Matsubara Tatsuaki; Uemura Arata; Iguchi Akihisa; Hotta Nigishi
Role of medial amygdala in controlling hemodynamics via GABA(A) receptor in anesthetized rats.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(2):197-203.
2002: Takeuchi N; Kawamura T; Kanai A; Nakamura N; Uno T; Hara T; Sano T; Sakamoto N; Hamada Y; Nakamura J; Hotta N
The effect of cigarette smoking on soluble adhesion molecules in middle-aged patients with Type 2 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2002;19(1):57-64.
2002: Wakai Kenji; Nakai Shigeru; Matsuo Seiichi; Kawamura Takashi; Hotta Nigishi; Maeda Kenji; Ohno Yoshiyuki;
Risk factors for IgA nephropathy: a case-control study with incident cases in Japan.
Nephron 2002;90(1):16-23.
2001: Sano T; Hotta N
[Diabetic retinopathy]
Nippon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 8():269-75.
2001: Hotta N
[Clinical difference between thiazolidinediones and biguanides]
Nippon rinsho. Japanese journal of clinical medicine 2001;59(11):2219-27.
2001: Hotta N; Toyota T; Matsuoka K; Shigeta Y; Kikkawa R; Kaneko T; Takahashi A; Sugimura K; Koike Y; Ishii J; Sakamoto N;
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study.
Diabetes care 2001;24(10):1776-82.
2001: Sato W; Kadomatsu K; Yuzawa Y; Muramatsu H; Hotta N; Matsuo S; Muramatsu T
Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3463-9.
2001: Ito I; Yuzawa Y; Mizuno M; Nishikawa K; Tashita A; Jomori T; Hotta N; Matsuo S
Effects of a new synthetic selectin blocker in an acute rat thrombotic glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;38(2):265-73.
2001: Nakayama M; Nakamura J; Hamada Y; Chaya S; Mizubayashi R; Yasuda Y; Kamiya H; Koh N; Hotta N
Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy.
Diabetes care 2001;24(6):1093-8.
2001: Kondo C; Mizuno M; Nishikawa K; Yuzawa Y; Hotta N; Matsuo S
The role of C5a in the development of thrombotic glomerulonephritis in rats.
Clinical and experimental immunology 2001;124(2):323-9.
2001: Nakamura J; Kasuya Y; Hamada Y; Nakashima E; Naruse K; Yasuda Y; Kato K; Hotta N
Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivity.
Diabetologia 2001;44(4):480-7.
2001: Yasuda Y; Nakamura J; Hamada Y; Nakayama M; Chaya S; Naruse K; Nakashima E; Kato K; Kamiya H; Hotta N
Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cells.
Biochemical and biophysical research communications 2001;281(1):71-7.
2001: Nakamura J; Hamada Y; Sakakibara F; Hara T; Wakao T; Mori K; Nakashima E; Naruse K; Kamijo M; Koh N; Hotta N
Physiological and morphometric analyses of neuropathy in sucrose-fed OLETF rats.
Diabetes research and clinical practice 2001;51(1):9-20.
2000: Yoshioka S; Uemura K; Tamaya N; Tamagawa T; Miura H; Iguchi A; Nakamura J; Hotta N
Dietary fat-induced increase in blood pressure and insulin resistance in rats.
Journal of hypertension 2000;18(12):1857-64.
2000: Hamada Y; Nakamura J; Naruse K; Komori T; Kato K; Kasuya Y; Nagai R; Horiuchi S; Hotta N
Epalrestat, an aldose reductase ihibitor, reduces the levels of Nepsilon-(carboxymethyl)lysine protein adducts and their precursors in erythrocytes from diabetic patients.
Diabetes care 2000;23(10):1539-44.
2000: Watanabe M; Morita Y; Mizuno M; Nishikawa K; Yuzawa Y; Hotta N; Morgan B P; Okada N; Okada H; Matsuo S
CD59 protects rat kidney from complement mediated injury in collaboration with crry.
Kidney international 2000;58(4):1569-79.
2000: Naruse K; Nakamura J; Hamada Y; Nakayama M; Chaya S; Komori T; Kato K; Kasuya Y; Miwa K; Hotta N
Aldose reductase inhibition prevents glucose-induced apoptosis in cultured bovine retinal microvascular pericytes.
Experimental eye research 2000;71(3):309-15.
2000: Mizuno M; Nishikawa K; Yuzawa Y; Kanie T; Mori H; Araki Y; Hotta N; Matsuo S
Acute renal failure after a sea anemone sting.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2000;36(2):E10.
2000: Amano T; Matsubara T; Watanabe J; Nakayama S; Hotta N
Insulin modulation of intracellular free magnesium in heart: involvement of protein kinase C.
British journal of pharmacology 2000;130(4):731-8.
2000: Morita Y; Ikeguchi H; Nakamura J; Hotta N; Yuzawa Y; Matsuo S
Complement activation products in the urine from proteinuric patients.
Journal of the American Society of Nephrology : JASN 2000;11(4):700-7.
1999: Kasuya Y; Ito M; Nakamura J; Hamada Y; Nakayama M; Chaya S; Komori T; Naruse K; Nakashima E; Kato K; Koh N; Hotta N
An aldose redutase inhibitor prevents the intimal thickening in coronary arteries of galactose-fed beagle dogs.
Diabetologia 1999;42(12):1404-9.
1999: Nakamura J; Kato K; Hamada Y; Nakayama M; Chaya S; Nakashima E; Naruse K; Kasuya Y; Mizubayashi R; Miwa K; Yasuda Y; Kamiya H; Ienaga K; Sakakibara F; Koh N; Hotta N
A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats.
Diabetes 1999;48(10):2090-5.
1999: Hamada Y; Nakamura J; Hotta N
[Aldose reductase]
Nippon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():425-7.
1999: Kasuya Y; Nakamura J; Hamada Y; Nakayama M; Sasaki H; Komori T; Chaya S; Watanabe G; Naruse K; Nakashima E; Kato K; Hotta N
An aldose reductase inhibitor prevents the glucose-induced increase in PDGF-beta receptor in cultured rat aortic smooth muscle cells.
Biochemical and biophysical research communications 1999;261(3):853-8.
1999: Kawakubo T; Naruse K; Matsubara T; Hotta N; Sokabe M
Characterization of a newly found stretch-activated KCa,ATP channel in cultured chick ventricular myocytes.
The American journal of physiology 1999;276(6 Pt 2):H1827-38.
1999: Wakai K; Kawamura T; Matsuo S; Hotta N; Ohno Y
Risk factors for IgA nephropathy: a case-control study in Japan.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1999;33(4):738-45.
1999: Suzuki K; Kawamura T; Sakakibara F; Sasaki H; Sano T; Sakamoto N; Hotta N
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(1):67-73.
1999: Uemura K; Yoshioka S; Surina-Baumgartner D M; Tamagawa T; Miura H; Ueda M; Tamaya N; Iguchi A; Hotta N
Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats.
Japanese journal of pharmacology 1999;79(1):113-5.
1999: Sasaki H; Nakamura J; Koh N; Hamada Y; Hara T; Chaya S; Nakashima E; Naruse K; Kato K; Kasuya Y; Sakakibara F; Hotta N
Effect of vitamin E and allylamine on the proliferation of cultured aortic smooth muscle cells from streptozotocin-induced diabetic rats.
Life sciences 1999;64(25):2317-25.
1998: Nakamura J; Koh N; Sakakibara F; Hamada Y; Hara T; Sasaki H; Chaya S; Komori T; Nakashima E; Naruse K; Kato K; Takeuchi N; Kasuya Y; Hotta N
Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats.
The Journal of pharmacology and experimental therapeutics 1998;287(3):897-902.
1998: Terada R; Matsubara T; Koh N; Nakamura J; Hotta N
Effects of propionyl-L-carnitine on cardiac dysfunction in streptozotocin-diabetic rats.
European journal of pharmacology 1998;357(2-3):185-91.
1998: Kawamura T; Umemura T; Kanai A; Uno T; Matsumae H; Sano T; Sakamoto N; Sakakibara T; Nakamura J; Hotta N
The incidence and characteristics of silent cerebral infarction in elderly diabetic patients: association with serum-soluble adhesion molecules.
Diabetologia 1998;41(8):911-7.
1998: Uemura A; Naito Y; Matsubara T; Hotta N; Hidaka H
Demonstration of a Ca2+/calmodulin dependent protein kinase cascade in the hog heart.
Biochemical and biophysical research communications 1998;249(2):355-60.
1998: Chen Y; Uemura K; Yoshioka S; Surina-Baumgartner D M; Miura H; Tamagawa T; Hotta N; Iguchi A
Centrally administered TRH-induced insulin secretion is impaired in the Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus.
Journal of the autonomic nervous system 1998;71(1):10-7.
1998: Hamada Y; Nishimura C; Koh N; Sakakibara F; Nakamura J; Tanimoto T; Hotta N
Influence of interindividual variability of aldose reductase protein content on polyol-pathway metabolites and redox state in erythrocytes in diabetic patients.
Diabetes care 1998;21(6):1014-8.
1998: Nakamura J; Hotta N
[Myo-inositol]
Nippon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():129-34.
1997: Hotta N
New concepts and insights on pathogenesis and treatment of diabetic complications: polyol pathway and its inhibition.
Nagoya journal of medical science 1997;60(3-4):89-100.
1997: Hotta N
[Epalrestat]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():204-11.
1997: Hara T; Hotta N
[Voglibose]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():114-9.
1997: Hotta N; Nakamura J; Sakakibara F; Hamada Y; Hara T; Mori K; Nakashima E; Sasaki H; Kasama N; Inukai S; Koh N
Electroretinogram in sucrose-fed diabetic rats treated with an aldose reductase inhibitor or an anticoagulant.
The American journal of physiology 1997;273(5 Pt 1):E965-71.
1997: Hamada Y; Hotta N
[Conservative therapy of diabetic retinopathy]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():971-6.
1997: Hotta N
[Metabolic disorder of polyol pathway]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():745-51.
1997: Nakamura J; Hotta N
[Risk factors for the development of diabetic complications]
Nippon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():725-30.
1997: Morita Y; Nomura A; Yuzawa Y; Nishikawa K; Hotta N; Shimizu F; Matsuo S
The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis.
Journal of the American Society of Nephrology : JASN 1997;8(9):1363-72.
1997: Hamada Y; Nakamura J; Fujisawa H; Yago H; Nakashima E; Koh N; Hotta N
Effects of glycemic control on plasma 3-deoxyglucosone levels in NIDDM patients.
Diabetes care 1997;20(9):1466-9.
1997: Uemura K; Tamagawa T; Chen Y; Maeda N; Yoshioka S; Itoh K; Miura H; Iguchi A; Hotta N
NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, affects the central nervous system to produce peripheral hyperglycemia in conscious rats.
Neuroendocrinology 1997;66(2):136-44.
1997: Mori Y; Matsuo S; Sutoh H; Toriyama T; Kawahara H; Hotta N
A case of a dialysis patient with sclerosing peritonitis successfully treated with corticosteroid therapy alone.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1997;30(2):275-8.
1997: Nomura A; Morita Y; Maruyama S; Hotta N; Nadai M; Wang L; Hasegawa T; Matsuo S
Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis.
The American journal of pathology 1997;151(2):539-47.
1997: Akahori T; Yuzawa Y; Nishikawa K; Tamatani T; Kannagi R; Miyasaka M; Okada H; Hotta N; Matsuo S
Role of a sialyl Lewis(x)-like epitope selectively expressed on vascular endothelial cells in local skin inflammation of the rat.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5384-92.
1997: Hotta N; Koh N; Sakakibara F; Nakamura J; Hara T; Hamada Y; Fukasawa H; Kakuta H; Sakamoto N
Effect of an aldose reductase inhibitor on abnormalities of electroretinogram and vascular factors in diabetic rats.
European journal of pharmacology 1997;326(1):45-51.
1997: Mori K; Nakamura J; Koh N; Sakakibara F; Hamada Y; Hara T; Komori T; Nakashima E; Naruse K; Takeuchi N; Hotta N
Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides.
Canadian journal of physiology and pharmacology 1997;75(3):179-84.
1997: Nakamura J; Koh N; Sakakibara F; Hamada Y; Wakao T; Sasaki H; Mori K; Nakashima E; Naruse K; Hotta N
Diabetic neuropathy in sucrose-fed Otsuka Long-Evans Tokushima fatty rats: effect of an aldose reductase inhibitor, TAT.
Life sciences 1997;60(21):1847-57.
1996: Hamada Y; Araki N; Koh N; Nakamura J; Horiuchi S; Hotta N
Rapid formation of advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway.
Biochemical and biophysical research communications 1996;228(2):539-43.
1996: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Hara T; Mori K; Naruse K; Fukasawa H; Kakuta H; Sakamoto N
Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant.
European journal of pharmacology 1996;313(3):201-9.
1996: Nakashima E; Nakamura J; Koh N; Sakakibara F; Hamada Y; Hotta N
Effect of a novel hypoglycemic agent, KAD-1229 on glucose metabolism and fructose-2,6-bisphosphate content in isolated hepatocytes of normal rats.
Diabetes research and clinical practice 1996;34(1):13-22.
1996: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Hara T; Fukasawa H; Kakuta H; Sakamoto N
Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats.
European journal of pharmacology 1996;311(2-3):199-206.
1996: Hara T; Nakamura J; Koh N; Sakakibara F; Takeuchi N; Hotta N
An importance of carbohydrate ingestion for the expression of the effect of alpha-glucosidase inhibitor in NIDDM.
Diabetes care 1996;19(6):642-7.
1996: Hotta N; Sakamoto N; Shigeta Y; Kikkawa R; Goto Y
Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan.
Journal of diabetes and its complications 1996;10(3):168-72.
1996: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Hara T; Mori K; Nakashima E; Naruse K; Fukasawa H; Kakuta H; Sakamoto N
Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes.
Diabetes 1996;45(3):361-366.
1996: Sano T; Hotta N; Kawamura T; Matsumae H; Chaya S; Sasaki H; Nakayama M; Hara T; Matsuo S; Sakamoto N
Effects of long-term enalapril treatment on persistent microalbuminuria in normotensive type 2 diabetic patients: results of a 4-year, prospective, randomized study.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(2):120-4.
1996: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamara Y; Hara T; Nakashima E; Sasaki H; Fukasawa H; Kakuta H; Sakamoto N
Effects of propionyl-L-carnitine and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes.
Pflügers Archiv : European journal of physiology 1996;431(4):564-70.
1996: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Wakao T; Hara T; Mori K; Naruse K; Nakashima E; Sakamoto N
Effect of propionyl-L-carnitine on motor nerve conduction, autonomic cardiac function, and nerve blood flow in rats with streptozotocin-induced diabetes: comparison with an aldose reductase inhibitor.
The Journal of pharmacology and experimental therapeutics 1996;276(1):49-55.
1996: Hamada Y; Araki N; Horiuchi S; Hotta N
Role of polyol pathway in nonenzymatic glycation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 5():95-8.
1996: Hotta N; Koh N; Sakakibara F; Naruse K; Yamada T; Takeuchi N; Yamada K; Fukasawa H; Kakuta H
Effect of acarbose on blood glucose profiles and plasma 1,5-anhydro-d-glucitol in type 2 diabetes poorly controlled by sulfonylurea therapy.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1996;50(6-7):297-302.
1996: Naruse K; Sakakibara F; Nakamura J; Koh N; Hotta N
Enhancement and inhibition of mitogenic action of insulin-like growth factor I by high glucose in cultured bovine retinal pericytes.
Life sciences 1996;58(4):267-76.
1995: Nakamura J; Koh N; Sakakibara F; Hamada Y; Wakao T; Hara T; Mori K; Nakashima E; Naruse K; Hotta N
Polyol pathway, 2,3-diphosphoglycerate in erythrocytes and diabetic neuropathy in rats.
European journal of pharmacology 1995;294(1):207-14.
1995: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Hara T; Takeuchi N; Inukai S; Kasama N; Fukasawa H
An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats.
European journal of clinical investigation 1995;25(12):948-54.
1995: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Naruse K; Sasaki H; Mizuno K; Matsubara A; Kakuta H
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats.
Experimental physiology 1995;80(6):981-9.
1995: Nakashima E; Nakamura J; Hamada Y; Koh N; Sakakibara F; Hotta N
Interference by gliclazide in the glucose oxidase/peroxidase method for glucose assay.
Diabetes research and clinical practice 1995;30(2):149-52.
1995: Hotta N; Nakamura J; Kakuta H; Fukasawa H; Koh N; Sakakibara F; Mori K; Sakamoto N
Niceritrol prevents the decrease in red blood cell 2,3-diphosphoglycerate and neuropathy in streptozotocin-induced diabetic rats.
Journal of diabetes and its complications 1995;9(3):133-9.
1995: Koh N; Hotta N
[Morbid obesity]
Nippon rinsho. Japanese journal of clinical medicine 1995;53 Suppl():511-4.
1995: Hotta N; Koh N; Sakakibara F; Nakamura J; Hamada Y; Wakao T; Hara T; Mori K; Naruse K; Nakashima W
Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats.
Prostaglandins 1995;49(6):339-49.
1995: Kawamura T; Suzuki K; Matsumae H; Sano T; Sakamoto N; Hotta N
Effects of glucose and SNK-860, an aldose reductase inhibitor, on the polyol pathway and chemiluminescence response of human neutrophils in vitro.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(5):392-6.
1995: Hotta N; Kakuta H; Fukasawa H; Koh N; Sakakibara F; Nakamura J; Hamada Y; Wakao T; Hara T; Mori K
Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.
Diabetes research and clinical practice 1995;27(2):107-17.
1995: Hamada Y; Odagaki Y; Sakakibara F; Naruse K; Koh N; Hotta N
Effects of an aldose reductase inhibitor on erythrocyte fructose 3-phosphate and sorbitol 3-phosphate levels in diabetic patients.
Life sciences 1995;57(1):23-9.
1995: Hotta N
New approaches for treatment in diabetes: aldose reductase inhibitors.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1995;49(5):232-43.
1995: Hotta N; Koh N; Sakakibara F; Nakamura J; Hara T; Yamada H; Hamada Y; Takeuchi N
Neurotropin prevents neurophysiological abnormalities and ADP-induced hyperaggregability in rats with streptozotocin-induced diabetes.
Life sciences 1995;57(23):2101-11.
1994: Hotta N; Sugimura K; Tsuchida I; Sano T; Koh N; Matsumae H; Sakamoto N
Use of the C64 quantitative tuning fork and the effect of niceritrol in diabetic neuropathy.
Clinical therapeutics 1994;16(6):1007-15.
1994: Sano T; Kawamura T; Matsumae H; Sasaki H; Nakayama M; Hara T; Matsuo S; Hotta N; Sakamoto N
Effects of long-term enalapril treatment on persistent micro-albuminuria in well-controlled hypertensive and normotensive NIDDM patients.
Diabetes care 1994;17(5):420-4.
1993: Sakakibara F; Hotta N; Koh N; Sakamoto N
Effects of high glucose concentrations and epalrestat on sorbitol and myo-inositol metabolism in cultured rabbit aortic smooth muscle cells.
Diabetes 1993;42(11):1594-600.
1993: Komori T; Hotta N; Kobayashi M; Sakakibara F; Koh N; Sakamoto N
Biguanides may produce hypoglycemic action in isolated rat hepatocytes through their effects on L-alanine transport.
Diabetes research and clinical practice 1993;22(1):11-7.
1993: Hotta N; Kakuta H; Koh N; Sakakibara F; Haga T; Sano T; Okuyama M; Sakamoto N
The effect of acarbose on blood glucose profiles of type 2 diabetic patients receiving insulin therapy.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(4):355-8.
1993: Hotta N; Kakuta H; Sano T; Matsumae H; Yamada H; Kitazawa S; Sakamoto N
Long-term effect of acarbose on glycaemic control in non-insulin-dependent diabetes mellitus: a placebo-controlled double-blind study.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(2):134-8.
1993: Hotta N; Komori T; Kobayashi M; Sakakibara F; Koh N; Sakamoto N
The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers.
Diabetes research and clinical practice 1993;19(1):49-58.
1993: Hotta N; Kawamori R; Sano T; Kakuta H; Kamada T; Sakamoto N
Diabetic neuropathy: effects of intensified glycaemic control with multiple insulin injections.
Diabetic medicine : a journal of the British Diabetic Association 1993;10 Suppl 2():91S-94S.
1992: Hotta N; Kakuta H; Fukasawa H; Koh N; Sakakibara F; Komori H; Sakamoto N
Effect of niceritrol on streptozocin-induced diabetic neuropathy in rats.
Diabetes 1992;41(5):587-91.
1991: Hotta N; Sakamoto N
Pathogenesis and correspondence of diabetic retinopathy--approach from polyol metabolism.
Japanese journal of medicine 1991;30(6):626-9.
1991: Hotta N; Kakuta H; Koh N; Fukasawa H; Yasuma T; Awaya S; Sakamoto N
In vitro retinal and erythrocyte polyol pathway regulation by hormones and an aldose reductase inhibitor.
Diabetes research and clinical practice 1991;14(1):29-35.
1991: Hotta N; Sakamoto N
[Diabetes mellitus and its complications in Japan. Pathogenesis and correspondence of diabetic retinopathy--approach from polyol metabolism]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1991;80(9):1451-6.
1991: Hotta N; Sano T
[Risk factors of developing diabetic complications]
Nippon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():9-17.
1991: Hotta N; Sakamoto N
[Abnormal metabolism of polyol pathway and diabetic complications]
Nippon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():59-67.
1991: Sakamoto N; Sakakibara F; Hotta N
[Conservative therapy of diabetic eye disease]
Nippon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():293-300.
1991: Hotta N; Sakamoto N
[Diabetic microangiopathy--pathogenesis]
Nippon rinsho. Japanese journal of clinical medicine 1991;49 Suppl():25-33.
1990: Sakamoto N; Kakuta H; Hotta N
[Clinical significance of measurement of sensation and nerve conduction velocity in the diagnosis of diabetic neuropathies]
Nippon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():595-600.
1990: Hotta N; Kakuta H; Ando F; Sakamoto N
Current progress in clinical trials of aldose reductase inhibitors in Japan.
Experimental eye research 1990;50(6):625-8.
1989: Kamei I; Hotta N; Kakuta H; Kimura M; Fukasawa H; Koh N; Sakamoto N
Effects of lipolytic and antilipolytic agents on glycerol and free fatty acid release from isolated adipocytes of normal and diabetic rats.
Nagoya journal of medical science 1989;51(1-4):17-23.
1988: Hotta N; Kakuta H; Fukasawa H; Kimura M; Koh N; Matsumae H; Fujimaki M; Sakamoto N
Efficacy of glucose, ouabain and an aldose reductase inhibitor on 2-[3H] myo-inositol uptake by human, rat and rabbit erythrocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1988;20(7):387-90.
1985: Hotta N; Kakuta H; Fukasawa H; Kimura M; Koh N; Iida M; Terashima H; Morimura T; Sakamoto N
Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats.
Diabetologia 1985;28(3):176-80.

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