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Lindsay Hough
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38
Nalwalk, Julia
16
Leurs, Rob
11
Timmerman, Henk
9
Menge, Wiro
8
Glick, Stanley
7
Svokos, Konstantina
7
Gogas, Kathleen
5
Wentland, Mark
5
Cannon, Keri
4
Stadel, Rebecca
3
De Esch, Iwan
3
Barnes, William
3
Boyd, DL
3
Langlais, Philip
2
Herrick-Davis, Katharine
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All Publications
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2008: Stadel Rebecca; Yang Jun; Nalwalk Julia W; Phillips James G; Hough Lindsay B
High-affinity binding of [3H]cimetidine to a heme-containing protein in rat brain.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(3):614-21.
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2007: Cannon Keri E; Leurs Rob; Hough Lindsay B
Activation of peripheral and spinal histamine H3 receptors inhibits formalin-induced inflammation and nociception, respectively.
Pharmacology, biochemistry, and behavior 2007;88(1):122-9.
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2007: Gehani Neal C; Nalwalk Julia W; Razdan Raj K; Martin Billy R; Sun Xufung; Wentland Mark; Abood Mary E; Hough Lindsay B
Significance of cannabinoid CB1 receptors in improgan antinociception.
The journal of pain : official journal of the American Pain Society 2007;8(11):850-60.
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2007: Hough L B; Menge W M P B; van de Stolpe A C; Nalwalk J W; Leurs R; de Esch I J P
Antinociceptive activity of furan-containing congeners of improgan and ranitidine.
Bioorganic & medicinal chemistry letters 2007;17(20):5715-9.
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2007: Salussolia Catherine L; Nalwalk Julia W; Hough Lindsay B
Improgan-induced hypothermia: a role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature.
Brain research 2007;1152():42-8.
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2007: Cannon Keri E; Chazot Paul L; Hann Victoria; Shenton Fiona; Hough Lindsay B; Rice Frank L
Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets.
Pain 2007;129(1-2):76-92.
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2007: Hough Lindsay B; Nalwalk Julia W; Phillips James G; Kern Brian; Shan Zhixing; Wentland Mark P; de Esch Iwan J P; Janssen Elwin; Barr Travis; Stadel Rebecca
CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.
Neuropharmacology 2007;52(5):1244-55.
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2006: Nalwalk Julia W; Svokos Konstantina; Hough Lindsay B
Cannabinoid-improgan cross-tolerance: Improgan is a cannabinomimetic analgesic lacking affinity at the cannabinoid CB1 receptor.
European journal of pharmacology 2006;549(1-3):79-83.
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2006: Hough Lindsay B; de Esch Iwan J P; Janssen Elwin; Phillips James; Svokos Konstantina; Kern Brian; Trachler Jennifer; Abood Mary E; Leurs Rob; Nalwalk Julia W
Antinociceptive activity of chemical congeners of improgan: optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic.
Neuropharmacology 2006;51(3):447-56.
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2005: Hough Lindsay B; Nalwalk Julia W; Lu Qun; Shan Zhixing; Svokos Konstantina; Wentland Mark P; Montero M José
Antinociceptive, brain-penetrating derivatives related to improgan, a non-opioid analgesic.
European journal of pharmacology 2005;522(1-3):38-46.
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2005: Taraschenko O D; Barnes W G; Herrick-Davis K; Yokoyama Y; Boyd D L; Hough L B
Actions of tacrine and galanthamine on histamine-N-methyltransferase.
Methods and findings in experimental and clinical pharmacology 2005;27(3):161-5.
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2005: Cannon Keri E; Hough Lindsay B
Inhibition of chemical and low-intensity mechanical nociception by activation of histamine H3 receptors.
The journal of pain : official journal of the American Pain Society 2005;6(3):193-200.
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2005: Nalwalk J W; Svokos K; Leurs R; Hough L B
Absence of 5-HT3 and cholinergic mechanisms in improgan antinociception.
Pharmacology, biochemistry, and behavior 2005;80(3):505-10.
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2004: Cannon Keri E; Fleck Mark W; Hough Lindsay B
Effects of cimetidine-like drugs on recombinant GABAA receptors.
Life sciences 2004;75(21):2551-8.
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2004: Nalwalk J W; Svokos K; Taraschenko O; Leurs R; Timmerman H; Hough L B
Activation of brain stem nuclei by improgan, a non-opioid analgesic.
Brain research 2004;1021(2):248-55.
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2004: Hough L B; Nalwalk J W; Svokos K; Leurs R; Timmermann H
Pain-relieving drugs and the brain histaminergic system: multiple analgesic mechanisms from histamine, improgan and cimetidine.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S43-4.
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2004: Barnes William G; Grinde Ellinor; Crawford Dana R; Herrick-Davis Katharine; Hough Lindsay B
Characterization of a new mRNA species from the human histamine N-methyltransferase gene.
Genomics 2004;83(1):168-71.
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2003: Cannon Keri E; Nalwalk Julia W; Stadel Rebecca; Ge P; Lawson D; Silos-Santiago I; Hough Lindsay B
Activation of spinal histamine H3 receptors inhibits mechanical nociception.
European journal of pharmacology 2003;470(3):139-47.
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2003: Izadi Mobarakeh Jalal; Nalwalk Julia W; Watanabe Takeshi; Sakurada Shinobu; Hoffman Marcel; Leurs Rob; Timmerman Henk; Silos-Santiago Immaculada; Yanai Kazuhiko; Hough Lindsay B
Improgan antinociception does not require neuronal histamine or histamine receptors.
Brain research 2003;974(1-2):146-52.
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2002: Hough L B; Nalwalk J W; Stadel R; Timmerman H; Leurs R; Paria B C; Wang X; Dey S K
Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors.
The Journal of pharmacology and experimental therapeutics 2002;303(1):314-22.
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2002: Barnes William G; Hough Lindsay B
Membrane-bound histamine N-methyltransferase in mouse brain: possible role in the synaptic inactivation of neuronal histamine.
Journal of neurochemistry 2002;82(5):1262-71.
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2002: Langlais Philip J; McRee Robert Carter; Nalwalk Julia A; Hough Lindsay B
Depletion of brain histamine produces regionally selective protection against thiamine deficiency-induced lesions in the rat.
Metabolic brain disease 2002;17(3):199-210.
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2001: Svokos K; Nalwalk J W; Leurs R; Menge W M; Timmerman H; Hough L B
A role for spinal, but not supraspinal, alpha(2) adrenergic receptors in the actions of improgan, a powerful, non-opioid analgesic.
Brain research 2001;923(1-2):12-9.
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2001: Barnes W; Boyd D; Hough L
Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site?
European journal of pharmacology 2001;431(2):215-21.
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2001: Hough L B; Nalwalk J W; Leurs R; Menge W M; Timmerman H
Significance of GABAergic systems in the action of improgan, a non-opioid analgesic.
Life sciences 2001;68(24):2751-7.
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2001: Hough L B
Genomics meets histamine receptors: new subtypes, new receptors.
Molecular pharmacology 2001;59(3):415-9.
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2000: Hough L B; Nalwalk J W; Chen Y; Schuller A; Zhu Y; Zhang J; Menge W M; Leurs R; Timmerman H; Pintar J E
Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.
Brain research 2000;880(1-2):102-8.
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2000: Hough L B; Bagal A A; Glick S D
Pharmacokinetic characterization of the indole alkaloid ibogaine in rats.
Methods and findings in experimental and clinical pharmacology 2000;22(2):77-81.
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2000: McRee R C; Terry-Ferguson M; Langlais P J; Chen Y; Nalwalk J W; Blumenstock F A; Hough L B
Increased histamine release and granulocytes within the thalamus of a rat model of Wernicke's encephalopathy.
Brain research 2000;858(2):227-36.
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2000: Hough L B; Nalwalk J W; Leurs R; Menge W M; Timmerman H
Antinociceptive activity of derivatives of improgran and burimamide.
Pharmacology, biochemistry, and behavior 2000;65(1):61-6.
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2000: Hough L B; Nalwalk J W; Barnes W G; Leurs R; Menge W M; Timmerman H; Wentland M
A third life for burimamide. Discovery and characterization of a novel class of non-opioid analgesics derived from histamine antagonists.
Annals of the New York Academy of Sciences 2000;909():25-40.
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1999: Yates S L; Tedford C E; Gregory R; Pawlowski G P; Handley M K; Boyd D L; Hough L B
Effects of selected histamine H3 receptor antagonists on tele-methylhistamine levels in rat cerebral cortex.
Biochemical pharmacology 1999;57(9):1059-66.
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1999: Hough L B; Nalwalk J W; Leurs R; Menge W M; Timmerman H
Antinociceptive activity of impentamine, a histamine congener, after CNS administration.
Life sciences 1999;64(5):PL79-86.
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1998: Bannoura M D; Nalwalk J W; Tang Y; Carlile M; Leurs R; Menge W M; Timmerman H; Hough L B
Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.
Brain research 1998;814(1-2):218-21.
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1997: Hough L B; Nalwalk J W; Li B Y; Leurs R; Menge W M; Timmerman H; Carlile M E; Cioffi C; Wentland M
Novel qualitative structure-activity relationships for the antinociceptive actions of H2 antagonists, H3 antagonists and derivatives.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1534-43.
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1997: Pearl S M; Hough L B; Boyd D L; Glick S D
Sex differences in ibogaine antagonism of morphine-induced locomotor activity and in ibogaine brain levels and metabolism.
Pharmacology, biochemistry, and behavior 1997;57(4):809-15.
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1997: Li B Y; Nalwalk J W; Hough L B
Effects of naltrexone and histamine antagonists on the antinociceptive activity of the cimetidine analog SKF92374 in rats.
Brain research 1997;748(1-2):168-74.
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1996: Bagal A A; Hough L B; Nalwalk J W; Glick S D
Modulation of morphine-induced antinociception by ibogaine and noribogaine.
Brain research 1996;741(1-2):258-62.
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1996: Prell G D; Hough L B; Khandelwal J; Green J P
Lack of a precursor-product relationship between histamine and its metabolites in brain after histidine loading.
Journal of neurochemistry 1996;67(5):1938-44.
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1996: Li B Y; Nalwalk J W; Barker L A; Cumming P; Parsons M E; Hough L B
Characterization of the antinociceptive properties of cimetidine and a structural analog.
The Journal of pharmacology and experimental therapeutics 1996;276(2):500-8.
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1996: Mischler S A; Hough L B; Battles A H
Characteristics of carbon dioxide-induced antinociception.
Pharmacology, biochemistry, and behavior 1996;53(1):205-12.
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1996: Hough L B; Pearl S M; Glick S D
Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration.
Life sciences 1996;58(7):PL119-22.
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1995: Tedford C E; Yates S L; Pawlowski G P; Nalwalk J W; Hough L B; Khan M A; Phillips J G; Durant G J; Frederickson R C
Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies.
The Journal of pharmacology and experimental therapeutics 1995;275(2):598-604.
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1995: Hough L B; Nalwalk J W
Role of stress in histamine-morphine interactions.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1995;44 Suppl 1():S40-1.
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1995: Nalwalk J W; Koch J E; Barke K E; Bodnar R J; Hough L B
Modulation of morphine antinociception by the brain-penetrating H2 antagonist zolantidine: detailed characterization in five nociceptive test systems.
Pharmacology, biochemistry, and behavior 1995;50(3):421-9.
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1995: Gallagher C A; Hough L B; Keefner S M; Seyed-Mozaffari A; Archer S; Glick S D
Identification and quantification of the indole alkaloid ibogaine in biological samples by gas chromatography-mass spectrometry.
Biochemical pharmacology 1995;49(1):73-9.
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1995: Nalwalk J W; Hough L B
Importance of histamine H2 receptors in restraint-morphine interactions.
Life sciences 1995;57(13):PL153-8.
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1994: Langlais P J; Zhang S X; Weilersbacher G; Hough L B; Barke K E
Histamine-mediated neuronal death in a rat model of Wernicke's encephalopathy.
Journal of neuroscience research 1994;38(5):565-74.
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1994: Thoburn K K; Hough L B; Nalwalk J W; Mischler S A
Histamine-induced modulation of nociceptive responses.
Pain 1994;58(1):29-37.
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1994: Barke K E; Hough L B
Characterization of basal and morphine-induced histamine release in the rat periaqueductal gray.
Journal of neurochemistry 1994;63(1):238-44.
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1994: Mischler S A; Alexander M; Battles A H; Raucci J A; Nalwalk J W; Hough L B
Prolonged antinociception following carbon dioxide anesthesia in the laboratory rat.
Brain research 1994;640(1-2):322-7.
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1994: Servos P; Barke K E; Hough L B; Vanderwolf C H
Histamine does not play an essential role in electrocortical activation during waking behavior.
Brain research 1994;636(1):98-102.
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1994: Skratt J J; Hough L B; Nalwalk J W; Barke K E
alpha-Fluoromethylhistidine-induced inhibition of brain histidine decarboxylase. Implications for the CO2-trapping enzymatic method.
Biochemical pharmacology 1994;47(2):397-402.
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1993: Barke K E; Hough L B
Simultaneous measurement of opiate-induced histamine release in the periaqueductal gray and opiate antinociception: an in vivo microdialysis study.
The Journal of pharmacology and experimental therapeutics 1993;266(2):934-42.
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1993: Barke K E; Hough L B
Opiates, mast cells and histamine release.
Life sciences 1993;53(18):1391-9.
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1992: Glick S D; Gallagher C A; Hough L B; Rossman K L; Maisonneuve I M
Differential effects of ibogaine pretreatment on brain levels of morphine and (+)-amphetamine.
Brain research 1992;588(1):173-6.
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1992: Hough L B; Nalwalk J W
Modulation of morphine antinociception by antagonism of H2 receptors in the periaqueductal gray.
Brain research 1992;588(1):58-66.
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1992: Hough L B; Nalwalk J W
Inhibition of morphine antinociception by centrally administered histamine H2 receptor antagonists.
European journal of pharmacology 1992;215(1):69-74.
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1992: Swaab R L; Battles A M; Bruner C A; Hough L B
Dimaprit--induced neurotoxicity.
Agents and actions 1992;35(3-4):179-84.
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1992: Barke K E; Hough L B
Morphine-induced increases of extracellular histamine levels in the periaqueductal grey in vivo: a microdialysis study.
Brain research 1992;572(1-2):146-53.
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1992: Koch J E; Hough L B; Bodnar R J
Potentiation of 2-deoxy-D-glucose antinociception, but not hyperphagia by zolantidine, a histamine (H2) receptor antagonist.
Pharmacology, biochemistry, and behavior 1992;41(2):371-6.
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1991: Kishikawa H; Willinger S M; Jackowski S; Barke K; Hough L B
Histidine decarboxylase measurement in brain by 14CO2 trapping.
Biochemical pharmacology 1991;42(2):217-22.
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1990: Hough L B; Nalwalk J W; Battles A H
Zolantidine-induced attenuation of morphine antinociception in rhesus monkeys.
Brain research 1990;526(1):153-5.
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1990: Licata S P; Nalwalk J W; Hough L B
Differential effects of morphine on histamine metabolism in brain and spinal cord of mice.
Brain research 1990;521(1-2):125-30.
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1990: Licata S P; Nalwalk J W; Hough L B
Actions of morphine on histamine dynamics in the mouse brain: a strain comparison.
Biochemical pharmacology 1990;39(5):978-81.
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1989: Gogas K R; Hough L B; Eberle N B; Lyon R A; Glick S D; Ward S J; Young R C; Parsons M E
A role for histamine and H2-receptors in opioid antinociception.
The Journal of pharmacology and experimental therapeutics 1989;250(2):476-84.
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1989: Prell G D; Khandelwal J K; Hough L B; Green J P
pros-methylimidazoleacetic acid in rat brain: its regional distribution and relationship to metabolic pathways of histamine.
Journal of neurochemistry 1989;52(2):561-7.
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1989: Gannon M N; Hough L B; Weinstein H
A metactoid sensitization model to describe multiple receptors linked to a common response: application to histamine receptors coupled to [3H]cyclic AMP accumulation in guinea pig cortex.
Molecular pharmacology 1989;35(2):205-13.
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1989: Gogas K R; Hough L B
Inhibition of naloxone-resistant antinociception by centrally administered H2-antagonists.
The Journal of pharmacology and experimental therapeutics 1989;248(1):262-7.
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1988: Hough L B; Jackowski S; Eberle N; Gogas K R; Camarota N A; Cue D
Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain.
Biochemical pharmacology 1988;37(24):4707-11.
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1988: Gogas K R; Hough L B
H2-receptor-mediated stress-induced analgesia is dependent on neither pituitary nor adrenal activation.
Pharmacology, biochemistry, and behavior 1988;30(3):791-4.
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1988: Gogas K R; Hough L B
Effects of zolantidine a brain-penetrating H2-receptor antagonist, on naloxone-sensitive and naloxone-resistant analgesia.
Neuropharmacology 1988;27(4):357-62.
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1988: Weinstein I J; Hough L B; Gogas K R
Cross-tolerance and cross-sensitization between morphine analgesia and naloxone-sensitive and cimetidine-sensitive stress-induced analgesia.
The Journal of pharmacology and experimental therapeutics 1988;244(1):253-8.
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1988: Gannon M N; Hough L B
Histamine receptors coupled to [3H]cAMP accumulation in brain: pharmacological characterization in a vesicular preparation of guinea pig cortex.
Molecular pharmacology 1988;33(1):44-50.
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1988: Licata S P; Werber A H; Hough L B
Cimetidine-sensitive analgesia: investigation of the importance of stress-induced changes in arterial pressure.
Physiology & behavior 1988;42(6):563-8.
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1987: Hough L B
Barbiturate-induced inhibition of rat brain histamine turnover.
Biochemical pharmacology 1987;36(19):3321-3.
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1986: Gannon M N; Hough L B
Properties of a 3H-adenine prelabeled vesicular preparation from guinea pig cerebral cortex. Optimization of incubation conditions for basal- and histamine-stimulated 3H-cyclic AMP levels.
Journal of pharmacological methods 1986;16(4):315-28.
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1986: Hough L B; Glick S D; Su K
Cimetidine penetrates brain and inhibits non-opiate footshock-induced analgesia.
Pharmacology, biochemistry, and behavior 1986;24(5):1257-61.
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1986: Gogas K R; Hough L B; Glick S D; Su K
Opposing actions of cimetidine on naloxone-sensitive and naloxone-insensitive forms of footshock-induced analgesia.
Brain research 1986;370(2):370-4.
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1986: Hough L B; Khandelwal J K; Green J P
Inhibition of brain histamine metabolism by metoprine.
Biochemical pharmacology 1986;35(2):307-10.
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1985: Goldschmidt R C; Hough L B; Glick S D
Rat brain mast cells: contribution to brain histamine levels.
Journal of neurochemistry 1985;44(6):1943-7.
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1985: Hough L B; Glick S D; Su K
A role for histamine and histamine H2-receptors in non-opiate footshock-induced analgesia.
Life sciences 1985;36(9):859-66.
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1984: Goldschmidt R C; Hough L B; Glick S D; Padawer J
Mast cells in rat thalamus: nuclear localization, sex difference and left-right asymmetry.
Brain research 1984;323(2):209-17.
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1984: Hough L B; Su K L; Goldschmidt R C; Khandelwal J K; Newton M V; Glick S D
No evidence for histamine-mediated morphine analgesia.
Neuropharmacology 1984;23(6):705-9.
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1984: Khandelwal J K; Hough L B; Green J P
Regional distribution of the histamine metabolite, tele-methylimidazoleacetic acid, in rat brain: effects of pargyline and probenecid.
Journal of neurochemistry 1984;42(2):519-22.
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1984: Goldschmidt R C; Khandelwal J K; Hough L B
Presence and measurement of tele-methylhistamine in mast cells.
Agents and actions 1984;14(2):174-8.
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1984: Hough L B; Khandelwal J K; Goldschmidt R C; Diomande M; Glick S D
Normal levels of histamine and tele-methylhistamine in mast cell-deficient mouse brain.
Brain research 1984;292(1):133-8.
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1984: Hough L B; Khandelwal J K; Green J P
Histamine turnover in regions of rat brain.
Brain research 1984;291(1):103-9.
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1983: Barker L A; Hough L B
Selectivity of 4-methylhistamine at H1- and H2-receptors in the guinea-pig isolated ileum.
British journal of pharmacology 1983;80(1):65-71.
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1982: Khandelwal J K; Hough L B; Morrishow A M; Green J P
Measurement of tele-methylhistamine and histamine in human cerebrospinal fluid, urine, and plasma.
Agents and actions 1982;12(5-6):583-90.
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1982: Hough L B; Khandelwal J K; Green J P
Effects of pargyline on tele-methylhistamine and histamine in rat brain.
Biochemical pharmacology 1982;31(24):4074-6.
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1982: Khandelwal J K; Hough L B; Green J P
Histamine and some of its metabolites in human body fluids.
Klinische Wochenschrift 1982;60(17):914-8.
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1982: Hough L B; Khandelwal J K; Green J P
Ontogeny of subcellular distribution of rat brain tele-methylhistamine.
Journal of neurochemistry 1982;38(6):1593-9.
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1982: Newton M V; Hough L B; Azmitia E C
Histamine-sensitive adenylate cyclase in monkey brain.
Brain research 1982;239(2):639-43.
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1981: Hough L B; Khandelwal J K; Mittag T W
Alpha-methylhistamine methylation by histamine methyltransferase.
Agents and actions 1981;11(5):425-8.
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1981: Hough L B; Barker L A
Histamine H2-receptor antagonism by propantheline and derivatives.
The Journal of pharmacology and experimental therapeutics 1981;219(2):453-8.
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1981: Hough L B; Khandelwal J K; Morrishow A M; Green J P
An improved GCMS method to measure tele-methylhistamine.
Journal of pharmacological methods 1981;5(2):143-8.
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