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Richard Houghten

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Jose Medina-Franco; Gregory S Welmaker; Giulianotti Marc; Richard A Houghten
Shifting from the single to the multitarget paradigm in drug discovery.
Kendall G Byler; Richard A Houghten; Yangmei Li; Karina Martinez-Mayorga
The role of imidazole in peptide cyclization by transesterification: parallels to the catalytic triads of serine proteases.
Christopher J Armishaw; Jayati Banerjee; Shainnel O Eans; Michelle L Ganno; Reena Gyanda; Michelle R Hoot; Richard A Houghten; Elisa Mizrachi; Kate J Reilley; Jay P McLaughlin
Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.

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All Publications

2013: Jose Medina-Franco; Gregory S Welmaker; Giulianotti Marc; Richard A Houghten
Shifting from the single to the multitarget paradigm in drug discovery.
Drug discovery today 2013;18(9-10):495-501.
2013: Kendall G Byler; Richard A Houghten; Yangmei Li; Karina Martinez-Mayorga
The role of imidazole in peptide cyclization by transesterification: parallels to the catalytic triads of serine proteases.
Organic & biomolecular chemistry 2013;11(18):2979-87.
2013: Christopher J Armishaw; Jayati Banerjee; Shainnel O Eans; Michelle L Ganno; Reena Gyanda; Michelle R Hoot; Richard A Houghten; Elisa Mizrachi; Kate J Reilley; Jay P McLaughlin
Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.
ACS combinatorial science 2013;15(3):153-61.
2013: Bainan Wu; Ziming Zhang; Clemencia Pinilla; Elisa Barile; Marc Giulianotti; Richard A Houghten; Roberta Noberini; Elena B Pasquale; Maurizio Pellecchia
HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.
Chemistry & biology 2013;20(1):19-33.
2013: Austin B Yongye; Mirella Vivoli; Jon R Appel; Richard A Houghten; Iris Lindberg; Karina Martinez-Mayorga
Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study.
PloS one 2013;8(2):e56957.
2012: Christine Levesque; Philippe Moussette; Witold Neugebauer; Adam Prahl; Sophie Routhier; Jon R Appel; Frédéric Couture; François D'Anjou; Roxane Desjardins; Yves L Dory; Martin Fugere; Richard A Houghten; Anna Kwiatkowska; Bernard Lammek; Robert Day
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Journal of medicinal chemistry 2012;55(23):10501-11.
2012: Yangmei Li; Laura Maida; Jaime A Misler; Margaret E Cazares; Ginamarie Debevec; Colette T Dooley; Giulianotti Marc; Richard A Houghten
Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.
ACS combinatorial science 2012;14(12):673-9.
2012: Jiaan Shao; Wenteng Chen; Marc A Giulianotti; Richard A Houghten; Yongping Yu
Palladium-catalyzed C-H functionalization using guanidine as a directing group: ortho arylation and olefination of arylguanidines.
Organic letters 2012;14(21):5452-5.
2012: Clemencia Pinilla; Valeria Judkowski; Jon R Appel; Richard A Houghten
Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2012;Chapter 9():Unit9.5.
2012: Dmitriy Minond; Nina Bionda; Mare Cudic; Marc Giulianotti; Richard A Houghten; Laura Maida; Gregg Fields
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.
The Journal of biological chemistry 2012;287(43):36473-87.
2012: Fabian López-Vallejo; Giulianotti Marc; Richard A Houghten; Jose Medina-Franco
Expanding the medicinally relevant chemical space with compound libraries.
Drug discovery today 2012;17(13-14):718-26.
2011: Jose Medina-Franco; Jaime Pérez-Villanueva; Austin B Yongye; Richard A Houghten; Karina Martínez-Mayorga
Multitarget structure-activity relationships characterized by activity-difference maps and consensus similarity measure.
Journal of chemical information and modeling 2011;51(9):2427-39.
2011: Fabian López-Vallejo; Karina Martínez-Mayorga; Thomas Caulfield; Giulianotti Marc; Richard A Houghten; Adel Nefzi; Jose Medina-Franco
Integrating virtual screening and combinatorial chemistry for accelerated drug discovery.
Combinatorial chemistry & high throughput screening 2011;14(6):475-87.
2011: Austin B Yongye; Clemencia Pinilla; Jose Medina-Franco; Giulianotti Marc; Colette T Dooley; Jon R Appel; Adel Nefzi; Thomas Scior; Richard A Houghten; Karina Martínez-Mayorga
Integrating computational and mixture-based screening of combinatorial libraries.
Journal of molecular modeling 2011;17(6):1473-82.
2011: Radleigh G Santos; Marc A Giulianotti; Colette T Dooley; Clemencia Pinilla; Jon R Appel; Richard A Houghten
Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.
ACS combinatorial science 2011;13(3):337-44.
2011: Fabian López-Vallejo; Adel Nefzi; Andreas Bender; John R Owen; Ian Nabney; Richard A Houghten; Jose Medina-Franco
Increased diversity of libraries from libraries: chemoinformatic analysis of bis-diazacyclic libraries.
Chemical biology & drug design 2011;77(5):328-42.
2010: Kate J Reilley; Giulianotti Marc; Colette T Dooley; Adel Nefzi; Jay P McLaughlin; Richard A Houghten
Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.
The AAPS journal 2010;12(3):318-29.
2010: Yangmei Li; Marc Giulionatti; Richard A Houghten
Macrolactonization of peptide thioesters catalyzed by imidazole and its application in the synthesis of kahalalide B and analogues.
Organic letters 2010;12(10):2250-3.
2010: Christopher J Armishaw; Narender Singh; Jose Medina-Franco; Richard J Clark; Krystle C M Scott; Richard A Houghten; Anders A Jensen
A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.
The Journal of biological chemistry 2010;285(3):1809-21.
2009: Yangmei Li; Austin Yongye; Giulianotti Marc; Karina Martinez-Mayorga; Yongping Yu; Richard A Houghten
Synthesis of cyclic peptides through direct aminolysis of peptide thioesters catalyzed by imidazole in aqueous organic solutions.
Journal of combinatorial chemistry 2009;11(6):1066-72.
2009: Adel Nefzi; Jon Appel; Sergey Arutyunyan; Richard A Houghten
Parallel synthesis of chiral pentaamines and pyrrolidine containing bis-heterocyclic libraries. Multiple scaffolds with multiple building blocks: a double diversity for the identification of new antitubercular compounds.
Bioorganic & medicinal chemistry letters 2009;19(17):5169-75.
2009: Austin B Yongye; Yangmei Li; Giulianotti Marc; Yongping Yu; Richard A Houghten; Karina Martínez-Mayorga
Modeling of peptides containing D-amino acids: implications on cyclization.
Journal of computer-aided molecular design 2009;23(9):677-89.
2009: Austin B Yongye; Jon R Appel; Giulianotti Marc; Colette T Dooley; Jose Medina-Franco; Adel Nefzi; Richard A Houghten; Karina Martínez-Mayorga
Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.
Bioorganic & medicinal chemistry 2009;17(15):5583-97.
2009: Narender Singh; Rajarshi Guha; Giulianotti Marc; Clemencia Pinilla; Richard A Houghten; Jose Medina-Franco
Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.
Journal of chemical information and modeling 2009;49(4):1010-24.
2009: Yangmei Li; Yongping Yu; Marc Giulianotti; Richard A Houghten
One-pot high-throughput synthesis of beta-turn cyclic peptidomimetics via "volatilizable" supports.
The Journal of organic chemistry 2009;74(5):2183-5.
2009: Dorota Kowalska; Jin Liu; Jon R Appel; Akihiko Ozawa; Adel Nefzi; Robert B Mackin; Richard A Houghten; Iris Lindberg
Synthetic small-molecule prohormone convertase 2 inhibitors.
Molecular pharmacology 2009;75(3):617-25.
2009: Jose Medina-Franco; Karina Martínez-Mayorga; Andreas Bender; Ray M Marín; Giulianotti Marc; Clemencia Pinilla; Richard A Houghten
Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs.
Journal of chemical information and modeling 2009;49(2):477-91.
2009: Hiroshi Nagasaki; Shinjae Chung; Colette T Dooley; Zhiwei Wang; Chunying Li; Yumiko Saito; Stewart D Clark; Richard A Houghten; Olivier Civelli
The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.
European journal of pharmacology 2009;602(2-3):194-202.
2008: Yangmei Li; Yongping Yu; Giulianotti Marc; Richard A Houghten
High throughput synthesis of peptide alpha-thioesters through the use of "volatilizable" support.
Journal of combinatorial chemistry 2008;10(5):613-6.
2008: Karina Martínez-Mayorga; Jose Medina-Franco; Giulianotti Marc; Clemencia Pinilla; Colette T Dooley; Jon R Appel; Richard A Houghten
Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.
Bioorganic & medicinal chemistry 2008;16(11):5932-8.
2008: Todd W Vanderah; Tally Largent-Milnes; Josephine Lai; Frank Porreca; Richard A Houghten; Frédérique Menzaghi; Kazimierz Wisniewski; Jacek Stalewski; Javier Sueiras-Diaz; Robert Galyean; Claudio D Schteingart; Jean-Louis Junien; Jerzy Trojnar; PJ Rivière
Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors.
European journal of pharmacology 2008;583(1):62-72.
2008: Richard A Houghten; Clemencia Pinilla; Giulianotti Marc; Jon R Appel; Colette T Dooley; Adel Nefzi; John M Ostresh; Yongping Yu; Gerald M Maggiora; Jose Medina-Franco; Daniela Brunner; Jeff Schneider
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Journal of combinatorial chemistry 2008;10(1):3-19.
2008: Saskia A G M Cillessen; John C Reed; Kate Welsh; Clemencia Pinilla; Richard A Houghten; Erik Hooijberg; José Deurhof; Kitty C M Castricum; Pim Kortman; Corine J Hess; Gert Ossenkoppele; Chris J L M Meijer; Joost Oudejans
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells.
Blood 2008;111(1):369-75.
2008: Yandong Zhang; Chao Yao; Richard A Houghten; Yongping Yu
Solid-phase synthesis of 4,8-disubstituted-8,9-dihydropyrazino[2,3-g]quinazolin-7(6H)-ones.
Biopolymers 2008;90(3):439-43.
2007: Jose Medina-Franco; Gerald M Maggiora; Giulianotti Marc; Clemencia Pinilla; Richard A Houghten
A similarity-based data-fusion approach to the visual characterization and comparison of compound databases.
Chemical biology & drug design 2007;70(5):393-412.
2007: Jinwen Xie; Jing Sun; Guolin Zhang; Richard A Houghten; Yongping Yu
A traceless approach for the solid-phase parallel synthesis of trisubstituted oxindoles.
Journal of combinatorial chemistry 2007;9(4):566-8.
2007: Yandong Zhang; Chuanlian Xu; Richard A Houghten; Yongping Yu
Scaffold approach for solid-phase synthesis of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines.
Journal of combinatorial chemistry 2007;9(1):9-11.
2007: Martin Fugere; Jon Appel; Richard A Houghten; Iris Lindberg; Robert Day
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences.
Molecular pharmacology 2007;71(1):323-32.
2006: Adel Nefzi; Cornelia E Hoesl; Clemencia Pinilla; George B Kauffman; Gerald M Maggiora; Elena Pasquale; Richard A Houghten
Synthesis of platinum(II) chiral tetraamine coordination complexes.
Journal of combinatorial chemistry 2006;8(5):780-3.
2006: Adel Nefzi; John M Ostresh; Jon R Appel; Jean Bidlack; Colette T Dooley; Richard A Houghten
Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.
Bioorganic & medicinal chemistry letters 2006;16(16):4331-8.
2006: Richard A Houghten; Colette T Dooley; Jon R Appel
In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.
The AAPS journal 2006;8(2):E371-82.
2006: Cornelia E Hoesl; John M Ostresh; Richard A Houghten; Adel Nefzi
Solid phase synthesis of 3,4,7-trisubstituted 4,5,8,9-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2(7H)-thiones and N-alkyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-a][1,3,5]triazepin-2-amines.
Journal of combinatorial chemistry 2006;8(1):127-31.
2005: Arnon P Kater; Frank Dicker; Massimo Mangiola; Kate Welsh; Richard A Houghten; John M Ostresh; Adel Nefzi; John C Reed; Clemencia Pinilla; Thomas Kipps
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis.
Blood 2005;106(5):1742-8.
2005: Richard A Houghten; Yongping Yu
"Volatilizable" supports for high-throughput organic synthesis.
Journal of the American Chemical Society 2005;127(24):8582-3.
2005: Bing Z Carter; Marcela Gronda; Zhiliang Wang; Kate Welsh; Clemencia Pinilla; Michael Andreeff; Wendy D Schober; Adel Nefzi; Gregory R Pond; Imtiaz A Mawji; Richard A Houghten; John M Ostresh; Joseph Brandwein; Mark D Minden; Andre C Schuh; Richard A Wells; Hans A Messner; Kathy Chun; John C Reed; Aaron D Schimmer
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells.
Blood 2005;105(10):4043-50.
2004: Zhiliang Wang; Michael Cuddy; Temesgen Samuel; Kate Welsh; Aaron D Schimmer; Farid Hanaii; Richard A Houghten; Clemencia Pinilla; John C Reed
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.
The Journal of biological chemistry 2004;279(46):48168-76.
2004: László Õrfi; Frigyes Wáczek; János Pató; István Varga; Bálint Hegymegi-Barakonyi; Richard A Houghten; György Kéri
Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs.
Current medicinal chemistry 2004;11(19):2549-53.
2004: Magdalena Kacprzak; Juan Peinado; Manuel E Than; Jon Appel; Stefan Henrich; Gregory M Lipkind; Richard A Houghten; Wolfram Bode; Iris Lindberg
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.
The Journal of biological chemistry 2004;279(35):36788-94.
2004: Adel Nefzi; John M Ostresh; Yongping Yu; Jongping Yu; Richard A Houghten
Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.
The Journal of organic chemistry 2004;69(11):3603-9.
2004: Richard A Houghten; Colette T Dooley; Jon R Appel
De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.
Bioorganic & medicinal chemistry letters 2004;14(8):1947-51.
2004: Cornelia E Hoesl; Adel Nefzi; Richard A Houghten
Halogenoalkyl isocyanates as bifunctional reagents in an Aza-Wittig/heterocyclization reaction on the solid phase: efficient entry into new tetracyclic benzimidazole systems.
Journal of combinatorial chemistry 2004;6(2):220-3.
2004: Jacqueline Shukaliak-Quandt; Eva Borras; Elisabetta Prat; Harald Gelderblom; Richard A Houghten; Azita Kashani; Clemencia Pinilla; Claus-Steffen Stuerzebecher; Roland Martin
Peptidic complex mixtures as therapeutic agents in CNS autoimmunity.
Molecular immunology 2004;40(14-15):1075-87.
2004: Darcy B Wilson; Dianne H Wilson; Kim Schroder; Clemencia Pinilla; Sylvie E Blondelle; Richard A Houghten; K Christopher Garcia
Specificity and degeneracy of T cells.
Molecular immunology 2004;40(14-15):1047-55.
2004: Aaron D Schimmer; Kate Welsh; Clemencia Pinilla; Zhiliang Wang; Maryla Krajewska; Marie-Josee Bonneau; Irene M Pedersen; Shinichi Kitada; Fiona L Scott; Beatrice Bailly-Maitre; Gennadi V Glinsky; Dominic A Scudiero; Edward A Sausville; Guy S Salvesen; Adel Nefzi; John M Ostresh; Richard A Houghten; John C Reed
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Cancer cell 2004;5(1):25-35.
2004: Yongping Yu; John M Ostresh; Richard A Houghten
A traceless approach for the solid-phase synthesis of 6-amino-1,3,5-triazine-2,4-diones.
Journal of combinatorial chemistry 2004;6(1):83-5.
2003: Christa Hamashin; Lisa Spindler; Shannon Russell; Amy Schink; Imelda Lambkin; Daniel J O'Mahony; Richard A Houghten; Clemencia Pinilla
Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery.
Bioorganic & medicinal chemistry 2003;11(23):4991-7.
2003: Imelda Lambkin; Clemencia Pinilla; Christa Hamashin; Lisa Spindler; Shannon Russell; Amy Schink; Rosa Moya-Castro; Gina Allicotti; Lisa Higgins; Melanie Smith; Jackie Dee; Carolyn Wilson; Richard A Houghten; Daniel J O'Mahony
Toward targeted oral vaccine delivery systems: selection of lectin mimetics from combinatorial libraries.
Pharmaceutical research 2003;20(8):1258-66.
2003: Cornelia E Hoesl; Adel Nefzi; Richard A Houghten
Parallel solid-phase synthesis of 2-imino-4-oxo-1,3,5-triazino[1,2-a]benzimidazoles via tandem aza-Wittig/heterocumulene-mediated annulation reaction.
Journal of combinatorial chemistry 2003;5(2):155-60.
2003: Yongping Yu; John M Ostresh; Richard A Houghten
The combined solid/solution-phase synthesis of nitrosamines: the evolution of the "libraries from libraries" concept.
The Journal of organic chemistry 2003;68(1):183-6.
2003: Cornelia E Hoesl; Adel Nefzi; John M Ostresh; Yongping Yu; Richard A Houghten
Mixture-based combinatorial libraries: from peptides and peptidomimetics to small molecule acyclic and heterocyclic compounds.
Methods in enzymology 2003;369():496-517.
2003: Adel Nefzi; John M Ostresh; Richard A Houghten
Combinatorial chemistry: mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides.
EXS 2003;(93):109-23.
2003: Clemencia Pinilla; Jon R Appel; Eva Borràs; Richard A Houghten
Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.
Nature medicine 2003;9(1):118-22.
2002: Verena Rubio-Godoy; Valérie Dutoit; Yingdong Zhao; Richard Simon; Philippe Guillaume; Richard A Houghten; Pedro Romero; Jean-Charles Cerottini; Clemencia Pinilla; Danila Valmori
Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5696-707.
2002: Markéta Rinnová; Adel Nefzi; Richard A Houghten
Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin.
Bioorganic & medicinal chemistry letters 2002;12(21):3175-8.
2002: Adel Nefzi; Richard A Mimna; Richard A Houghten
Parallel solid-phase synthesis of disubstituted 1,6-piperazine-2-ones.
Journal of combinatorial chemistry 2002;4(6):542-5.
2002: Achyuta N Acharya; John M Ostresh; Richard A Houghten
Determination of isokinetic ratios necessary for equimolar incorporation of carboxylic acids in the solid-phase synthesis of mixture-based combinatorial libraries.
Biopolymers 2002;65(1):32-9.
2002: Achyuta N Acharya; Cattram Thai; John M Ostresh; Richard A Houghten
Use of Vilsmeier reagent for the solid-phase synthesis of 1,5-disubstituted 4,5-dihydro-1H-imidazoles and disubstituted 4,5-dihydro-1H-imidazolylbenzimidazoles.
Journal of combinatorial chemistry 2002;4(5):496-500.
2002: Yongping Yu; John M Ostresh; Richard A Houghten
Efficient solid-phase synthesis of 1,3,5-trisubstituted 1,3,5-triazine-2,4,6-triones.
Journal of combinatorial chemistry 2002;4(5):484-90.
2002: Eva Borràs; Roland Martin; Valeria Judkowski; Jacqueline Shukaliak; Yingdong Zhao; Verena Rubio-Godoy; Danila Valmori; Darcy Wilson; Richard Simon; Richard A Houghten; Clemencia Pinilla
Findings on T cell specificity revealed by synthetic combinatorial libraries.
Journal of immunological methods 2002;267(1):79-97.
2002: Yongping Yu; John M Ostresh; Richard A Houghten
A traceless approach for the parallel solid-phase synthesis of 2-(arylamino)quinazolinones.
The Journal of organic chemistry 2002;67(16):5831-4.
2002: Verena Rubio-Godoy; Maha Ayyoub; Valérie Dutoit; Catherine Servis; Amy Schink; Donata Rimoldi; Pedro Romero; Jean-Charles Cerottini; Richard Simon; Yindong Zhao; Richard A Houghten; Clemencia Pinilla; Danila Valmori
Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity.
European journal of immunology 2002;32(8):2292-9.
2002: Valérie Dutoit; Verena Rubio-Godoy; Mikaël J Pittet; Alfred Zippelius; Pierre-Yves Dietrich; Frédérique Anne Legal; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Richard A Houghten; Clemencia Pinilla; Danila Valmori
Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans.
The Journal of experimental medicine 2002;196(2):207-16.
2002: Gérard Klein; Achyuta N Acharya; John M Ostresh; Richard A Houghten
Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones.
Journal of combinatorial chemistry 2002;4(4):345-51.
2002: Yongping Yu; John M Ostresh; Richard A Houghten
Solid-phase synthesis of 1,5-disubstituted 2-aryliminoimidazolidines.
The Journal of organic chemistry 2002;67(9):3138-41.
2002: Achyuta N Acharya; John M Ostresh; Richard A Houghten
Novel approaches for the solid-phase synthesis of biheterocyclic dihydroimidazole analogues.
Journal of combinatorial chemistry 2002;4(3):214-22.
2002: Markéta Rinnová; Agnès Vidal; Adel Nefzi; Richard A Houghten
Solid-phase synthesis of 1,2,5-trisubstituted 4-imidazolidinones.
Journal of combinatorial chemistry 2002;4(3):209-13.
2002: Verena Rubio-Godoy; Clemencia Pinilla; Valérie Dutoit; Eva Borras; Richard Simon; Yingdong Zhao; Jean-Charles Cerottini; Pedro Romero; Richard A Houghten; Danila Valmori
Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8+ Tumor-reactive T-Cell Ligands: a comparative analysis of PS-SCL recognition by a single tumor-reactive CD8+ cytolytic T-lymphocyte clone.
Cancer research 2002;62(7):2058-63.
2002: Adel Nefzi; Giulianotti Marc; Long Truong; Somkit Rattan; John M Ostresh; Richard A Houghten
Solid-phase synthesis of linear ureas tethered to hydantoins and thiohydantoins.
Journal of combinatorial chemistry 2002;4(2):175-8.
2001: Achyuta N Acharya; John M Ostresh; Richard A Houghten
A novel approach for solid-phase synthesis of substituted imidazolines and bis-imidazolines.
The Journal of organic chemistry 2001;66(25):8673-6.
2001: A Vidal; Adel Nefzi; Richard A Houghten
Solid-phase synthesis of alpha,alpha-difluoro-beta-amino acids via the Reformatsky reaction.
The Journal of organic chemistry 2001;66(24):8268-72.
2001: Achyuta N Acharya; John M Ostresh; Richard A Houghten
Solid-phase synthesis of substituted imidazoline-tethered 2,3-diketopiperazines, cyclic ureas, and cyclic thioureas.
Journal of combinatorial chemistry 2001;3(6):612-23.
2001: Achyuta N Acharya; John M Ostresh; Richard A Houghten
A novel approach for the solid-phase synthesis of substituted cyclic guanidines, their respective bis analogues, and N-acylated guanidines from N-acylated amino acid amides.
Journal of combinatorial chemistry 2001;3(6):578-89.
2001: Yongping Yu; John M Ostresh; Richard A Houghten
Solid-phase synthesis of 2,3,5-trisubstituted 4H-imidazolones.
Journal of combinatorial chemistry 2001;3(6):521-3.
2001: Y Yu; John M Ostresh; Richard A Houghten
Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones.
Organic letters 2001;3(18):2797-9.
2001: Clemencia Pinilla; Verena Rubio-Godoy; Valérie Dutoit; Philippe Guillaume; R Simon; Y Zhao; Richard A Houghten; Jean-Charles Cerottini; P Romero; Danila Valmori
Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.
Cancer research 2001;61(13):5153-60.
2001: Achyuta N Acharya; Adel Nefzi; John M Ostresh; Richard A Houghten
Tethered libraries: solid-phase synthesis of substituted urea-linked bicyclic guanidines.
Journal of combinatorial chemistry 2001;3(2):189-95.
2001: Adel Nefzi; John M Ostresh; Richard A Houghten
Solid phase synthesis of mixture-based acyclic and heterocyclic small molecule combinatorial libraries from resin-bound polyamides.
Biopolymers 2001;60(3):212-9.
2001: Adel Nefzi; Giulianotti Marc; Richard A Houghten
Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine.
Journal of combinatorial chemistry 2001;3(1):68-70.
2000: Angus Cameron; Jon Appel; Richard A Houghten; Iris Lindberg
Polyarginines are potent furin inhibitors.
The Journal of biological chemistry 2000;275(47):36741-9.
2000: Adel Nefzi; Giulianotti Marc; N A Ong; Richard A Houghten
Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.
Organic letters 2000;2(21):3349-50.
2000: Colette T Dooley; Richard A Houghten
Orphanin FQ/nociceptin receptor binding studies.
Peptides 2000;21(7):949-60.
2000: Natàlia Reixach; Emma T Crooks; John M Ostresh; Richard A Houghten; Sylvie E Blondelle
Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library.
Journal of structural biology 2000;130(2-3):247-58.
2000: Bernhard Hemmer; T Kondo; Bruno Gran; Clemencia Pinilla; I Cortese; J Pascal; A Tzou; Henry McFarland; Richard A Houghten; Roland Martin
Minimal peptide length requirements for CD4(+) T cell clones--implications for molecular mimicry and T cell survival.
International immunology 2000;12(3):375-83.
2000: Bernhard Hemmer; Clemencia Pinilla; Bruno Gran; Marco Vergelli; NC Ling; Paul Conlon; Henry McFarland; Richard A Houghten; Roland Martin
Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):861-71.
1999: Darcy B Wilson; Clemencia Pinilla; Dianne H Wilson; Kim Schroder; Cesar Boggiano; Valeria Judkowski; J Kaye; B Hemmer; Roland Martin; Richard A Houghten
Immunogenicity. I. Use of peptide libraries to identify epitopes that activate clonotypic CD4+ T cells and induce T cell responses to native peptide ligands.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(12):6424-34.
1999: Bernhard Hemmer; Bruno Gran; Yingdong Zhao; Adriana Marques; J Pascal; A Tzou; T Kondo; I Cortese; Bibiana Bielekova; S E Straus; Henry McFarland; Richard A Houghten; Richard Simon; Clemencia Pinilla; Roland Martin
Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease.
Nature medicine 1999;5(12):1375-82.
1999: Richard A Houghten; Clemencia Pinilla; Jon R Appel; Sylvie E Blondelle; Colette T Dooley; Jutta Eichler; Adel Nefzi; John M Ostresh
Mixture-based synthetic combinatorial libraries.
Journal of medicinal chemistry 1999;42(19):3743-78.
1999: Clemencia Pinilla; Roland Martin; Bruno Gran; J R Appel; Cesar Boggiano; Darcy B Wilson; Richard A Houghten
Exploring immunological specificity using synthetic peptide combinatorial libraries.
Current opinion in immunology 1999;11(2):193-202.
1999: Colette T Dooley; Richard A Houghten
New opioid peptides, peptidomimetics, and heterocyclic compounds from combinatorial libraries.
Biopolymers 1999;51(6):379-90.
1999: Sylvie E Blondelle; Emma T Crooks; John M Ostresh; Richard A Houghten
Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.
Antimicrobial agents and chemotherapy 1999;43(1):106-14.
1998: J R Appel; G D Campbell; J Buencamino; Richard A Houghten; Clemencia Pinilla
Characterization of antigen-antibody interactions using single substitution analogs and mixture-based synthetic combinatorial libraries.
The journal of peptide research : official journal of the American Peptide Society 1998;52(5):346-55.
1998: Bernhard Hemmer; Clemencia Pinilla; J Appel; J Pascal; Richard A Houghten; Roland Martin
The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells.
The journal of peptide research : official journal of the American Peptide Society 1998;52(5):338-45.
1998: Ekaterina V Apletalina; Jon Appel; NS Lamango; Richard A Houghten; Iris Lindberg
Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.
The Journal of biological chemistry 1998;273(41):26589-95.
1998: Adel Nefzi; Colette T Dooley; John M Ostresh; Richard A Houghten
Combinatorial chemistry: from peptides and peptidomimetics to small organic and heterocyclic compounds.
Bioorganic & medicinal chemistry letters 1998;8(17):2273-8.
1998: Colette T Dooley; P Ny; J M Bidlack; Richard A Houghten
Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library.
The Journal of biological chemistry 1998;273(30):18848-56.
1998: David Steer; Philip E Thompson; Sylvie E Blondelle; Richard A Houghten; Marie-Isabel Aguilar
Comparison of the binding of alpha-helical and beta-sheet peptides to a hydrophobic surface.
The journal of peptide research : official journal of the American Peptide Society 1998;51(6):401-12.
1998: Bernhard Hemmer; Marco Vergelli; Bruno Gran; NC Ling; Paul Conlon; Clemencia Pinilla; Richard A Houghten; Henry McFarland; Roland Martin
Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3631-6.
1998: Bernhard Hemmer; Marco Vergelli; Clemencia Pinilla; Richard A Houghten; Roland Martin
Probing degeneracy in T-cell recognition using peptide combinatorial libraries.
Immunology today 1998;19(4):163-8.
1998: Antonio Ferrer-Montiel; Jaime M Merino; Sylvie E Blondelle; E Perez-Payà; Richard A Houghten; Mauricio Montal
Selected peptides targeted to the NMDA receptor channel protect neurons from excitotoxic death.
Nature biotechnology 1998;16(3):286-91.
1998: J R Appel; J Johnson; V L Narayanan; Richard A Houghten
Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays.
Molecular diversity 1998;4(2):91-102.
1998: John M Ostresh; B Dörner; Richard A Houghten
Peralkylation. "Libraries from libraries": chemical transformation of synthetic combinatorial libraries.
Methods in molecular biology (Clifton, N.J.) 1998;87():41-9.
1998: Colette T Dooley; Richard A Houghten
Synthesis and screening of positional scanning combinatorial libraries.
Methods in molecular biology (Clifton, N.J.) 1998;87():13-24.
1997: Colette T Dooley; C G Spaeth; Ilona P Berzetei-Gurske; K Craymer; ID Adapa; S R Brandt; Richard A Houghten; Lawrence Toll
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.
The Journal of pharmacology and experimental therapeutics 1997;283(2):735-41.
1997: Sylvie E Blondelle; B Forood; Richard A Houghten; Enrique Perez-Paya
Secondary structure induction in aqueous vs membrane-like environments.
Biopolymers 1997;42(4):489-98.
1997: Sylvie E Blondelle; B Forood; Richard A Houghten; Enrique Perez-Paya
Polyalanine-based peptides as models for self-associated beta-pleated-sheet complexes.
Biochemistry 1997;36(27):8393-400.
1996: Richard A Houghten; Sylvie E Blondelle; Colette T Dooley; B Dörner; Jutta Eichler; John M Ostresh
Libraries from libraries: generation and comparison of screening profiles.
Molecular diversity 1996;2(1-2):41-5.
1996: J R Appel; J Buencamino; Richard A Houghten; Clemencia Pinilla
Exploring antibody polyspecificity using synthetic combinatorial libraries.
Molecular diversity 1996;2(1-2):29-34.
1996: Enrique Perez-Paya; B Forood; Richard A Houghten; Sylvie E Blondelle
Structural characterization and 5'-mononucleotide binding of polyalanine beta-sheet complexes.
Journal of molecular recognition : JMR 1996;9(5-6):488-93.
1996: Jutta Eichler; A W Lucka; Clemencia Pinilla; Richard A Houghten
Novel alpha-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries.
Molecular diversity 1996;1(4):233-40.
1996: Jutta Eichler; Richard A Houghten; Michal Lebl
Inclusion volume solid-phase synthesis.
Journal of peptide science : an official publication of the European Peptide Society 1996;2(4):240-4.
1996: J R Appel; S Muller; N Benkirane; Richard A Houghten; Clemencia Pinilla
Highly specific, cross-reactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library.
Peptide research 1996;9(4):174-82.
1996: B Dörner; G M Husar; John M Ostresh; Richard A Houghten
The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations.
Bioorganic & medicinal chemistry 1996;4(5):709-15.
1996: Sylvie E Blondelle; Enrique Perez-Paya; Richard A Houghten
Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.
Antimicrobial agents and chemotherapy 1996;40(5):1067-71.
1996: Sylvie E Blondelle; Richard A Houghten; Enrique Perez-Paya
All D-amino acid hexapeptide inhibitors of melittin's cytolytic activity derived from synthetic combinatorial libraries.
Journal of molecular recognition : JMR 1996;9(2):163-8.
1996: Enrique Perez-Paya; Richard A Houghten; Sylvie E Blondelle
Functionalized protein-like structures from conformationally defined synthetic combinatorial libraries.
The Journal of biological chemistry 1996;271(8):4120-6.
1996: Sylvie E Blondelle; Richard A Houghten; Enrique Perez-Paya
Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries.
The Journal of biological chemistry 1996;271(8):4093-9.
1996: Clemencia Pinilla; J R Appel; Richard A Houghten
Tea bag synthesis of positional scanning synthetic combinatorial libraries and their use for mapping antigenic determinants.
Methods in molecular biology (Clifton, N.J.) 1996;66():171-9.
1996: John M Ostresh; Sylvie E Blondelle; B Dörner; Richard A Houghten
Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries.
Methods in enzymology 1996;267():220-34.
1996: Colette T Dooley; Richard A Houghten
Orphanin FQ: receptor binding and analog structure activity relationships in rat brain.
Life sciences 1996;59(1):PL23-9.
1996: Sylvie E Blondelle; E Takahashi; Richard A Houghten; Enrique Perez-Paya
Rapid identification of compounds with enhanced antimicrobial activity by using conformationally defined combinatorial libraries.
The Biochemical journal 1996;313 ( Pt 1)():141-7.
1995: José F Marcos; R N Beachy; Richard A Houghten; Sylvie E Blondelle; Enrique Perez-Paya
Inhibition of a plant virus infection by analogs of melittin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12466-9.
1995: Jutta Eichler; J R Appel; Sylvie E Blondelle; Colette T Dooley; B Dörner; John M Ostresh; Enrique Perez-Paya; Clemencia Pinilla; Richard A Houghten
Peptide, peptidomimetic, and organic synthetic combinatorial libraries.
Medicinal research reviews 1995;15(6):481-96.
1995: Ismael Mingarro; Enrique Perez-Paya; Clemencia Pinilla; J R Appel; Richard A Houghten; Sylvie E Blondelle
Activation of bee venom phospholipase A2 through a peptide-enzyme complex.
FEBS letters 1995;372(1):131-4.
1995: Clemencia Pinilla; J Buencamino; J R Appel; T P Hopp; Richard A Houghten
Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: identification of potent calcium-independent antigens.
Molecular diversity 1995;1(1):21-8.
1995: Clemencia Pinilla; S Chendra; J R Appel; Richard A Houghten
Elucidation of monoclonal antibody polyspecificity using a synthetic combinatorial library.
Peptide research 1995;8(5):250-7.
1995: Sylvie E Blondelle; Enrique Perez-Paya; G Allicotti; B Forood; Richard A Houghten
Peptide binding domains determined through chemical modification of the side-chain functional groups.
Biophysical journal 1995;69(2):604-11.
1995: Jutta Eichler; Richard A Houghten
Generation and utilization of synthetic combinatorial libraries.
Molecular medicine today 1995;1(4):174-80.
1995: B Forood; Enrique Perez-Paya; Richard A Houghten; Sylvie E Blondelle
Formation of an extremely stable polyalanine beta-sheet macromolecule.
Biochemical and biophysical research communications 1995;211(1):7-13.
1995: Colette T Dooley; R A Kaplan; Nga N Chung; Peter W Schiller; Jean M Bidlack; Richard A Houghten
Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries.
Peptide research 1995;8(3):124-37.
1995: Enrique Perez-Paya; Richard A Houghten; Sylvie E Blondelle
The role of amphipathicity in the folding, self-association and biological activity of multiple subunit small proteins.
The Journal of biological chemistry 1995;270(3):1048-56.
1995: Clemencia Pinilla; J Buencamino; J R Appel; Richard A Houghten; J A Brassard; Z M Ruggeri
Two antipeptide monoclonal antibodies that recognize adhesive sequences in fibrinogen: identification of antigenic determinants and unrelated sequences using synthetic combinatorial libraries.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity 1995;1(3):199-204.
1995: Clemencia Pinilla; J Appel; Sylvie E Blondelle; Colette T Dooley; B Dörner; Jutta Eichler; John M Ostresh; Richard A Houghten
A review of the utility of soluble peptide combinatorial libraries.
Biopolymers 1995;37(3):221-40.
1995: Sylvie E Blondelle; John M Ostresh; Richard A Houghten; Enrique Perez-Paya
Induced conformational states of amphipathic peptides in aqueous/lipid environments.
Biophysical journal 1995;68(1):351-9.
1994: Colette T Dooley; Nga N Chung; Brian C Wilkes; Peter W Schiller; Jean M Bidlack; Gavril W Pasternak; Richard A Houghten
An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library.
Science (New York, N.Y.) 1994;266(5193):2019-22.
1994: John M Ostresh; J H Winkle; V T Hamashin; Richard A Houghten
Peptide libraries: determination of relative reaction rates of protected amino acids in competitive couplings.
Biopolymers 1994;34(12):1681-9.
1994: John M Ostresh; G M Husar; Sylvie E Blondelle; B Dörner; P A Weber; Richard A Houghten
"Libraries from libraries": chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11138-42.
1994: Jutta Eichler; A W Lucka; Richard A Houghten
Cyclic peptide template combinatorial libraries: synthesis and identification of chymotrypsin inhibitors.
Peptide research 1994;7(6):300-7.
1994: Enrique Perez-Paya; Richard A Houghten; Sylvie E Blondelle
Synthetic peptides as binding-step based catalytic mimics.
Peptide research 1994;7(6):286-8.
1994: Sylvie E Blondelle; E Takahashi; P A Weber; Richard A Houghten
Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids.
Antimicrobial agents and chemotherapy 1994;38(10):2280-6.
1994: Clemencia Pinilla; J R Appel; Richard A Houghten
Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 10(12) sequences.
The Biochemical journal 1994;301 ( Pt 3)():847-53.
1994: Enrique Perez-Paya; Richard A Houghten; Sylvie E Blondelle
Determination of the secondary structure of selected melittin analogues with different haemolytic activities.
The Biochemical journal 1994;299 ( Pt 2)():587-91.
1993: Colette T Dooley; Nga N Chung; Peter W Schiller; Richard A Houghten
Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10811-5.
1993: Sylvie E Blondelle; L R Simpkins; Enrique Perez-Paya; Richard A Houghten
Influence of tryptophan residues on melittin's hemolytic activity.
Biochimica et biophysica acta 1993;1202(2):331-6.
1993: Clemencia Pinilla; J R Appel; Richard A Houghten
Functional importance of amino acid residues making up peptide antigenic determinants.
Molecular immunology 1993;30(6):577-85.
1993: Colette T Dooley; Richard A Houghten
The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands.
Life sciences 1993;52(18):1509-17.
1993: Richard A Houghten; Colette T Dooley
Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors.
NIDA research monograph 1993;134():66-74.
1992: Sylvie E Blondelle; Richard A Houghten
Design of model amphipathic peptides having potent antimicrobial activities.
Biochemistry 1992;31(50):12688-94.
1992: Clemencia Pinilla; J R Appel; P Blanc; Richard A Houghten
Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries.
BioTechniques 1992;13(6):901-5.
1992: Sylvie E Blondelle; K Büttner; Richard A Houghten
Evaluation of peptide-peptide interactions using reversed-phase high-performance liquid chromatography.
Journal of chromatography 1992;625(2):199-206.
1992: K Büttner; Clemencia Pinilla; J R Appel; Richard A Houghten
Anomalous reversed-phase high-performance liquid chromatographic behavior of synthetic peptides related to antigenic helper T cell sites.
Journal of chromatography 1992;625(2):191-8.
1992: Richard A Houghten; J R Appel; Sylvie E Blondelle; J H Cuervo; Colette T Dooley; Clemencia Pinilla
The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides.
BioTechniques 1992;13(3):412-21.
1992: K Büttner; Sylvie E Blondelle; John M Ostresh; Richard A Houghten
Perturbation of peptide conformations induced in anisotropic environments.
Biopolymers 1992;32(6):575-83.
1991: Richard A Houghten; Clemencia Pinilla; Sylvie E Blondelle; J R Appel; Colette T Dooley; J H Cuervo
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery.
Nature 1991;354(6348):84-6.
1991: Sylvie E Blondelle; Richard A Houghten
Hemolytic and antimicrobial activities of the twenty-four individual omission analogues of melittin.
Biochemistry 1991;30(19):4671-8.
1991: Sylvie E Blondelle; Richard A Houghten
Probing the relationships between the structure and hemolytic activity of melittin with a complete set of leucine substitution analogs.
Peptide research 1991;4(1):12-8.
1990: J R Appel; Clemencia Pinilla; H Niman; Richard A Houghten
Elucidation of discontinuous linear determinants in peptides.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):976-83.
1990: O Arad; Richard A Houghten
An evaluation of the advantages and effectiveness of picric acid monitoring during solid phase peptide synthesis.
Peptide research 1990;3(1):42-50.