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Mann-Jen Hour

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Hui-Jye Chen; Shinji Fushiya; Mann-Jen Hour; Yi-Lin Jiang; Chung-Ming Lin; Shu-Fen Peng; Shih-Chang Tsai; Jai-Sing Yang
Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
Jo-Hua Chiang; Shu-Jen Chang; Mann-Jen Hour; Tsung-Han Lee; Chi-Cheng Lu; Jai-Sing Yang; Jing-Gung Chung
Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.
Mann-Jen Hour; Tai-Lin Chen; Kun-Tsung Lee; Chi-Yu Wu; Yang-Chang Wu; Bang-Jau You; Hong-Zin Lee
A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.

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All Publications

2013: Hui-Jye Chen; Shinji Fushiya; Mann-Jen Hour; Yi-Lin Jiang; Chung-Ming Lin; Shu-Fen Peng; Shih-Chang Tsai; Jai-Sing Yang
Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
International journal of oncology 2013;43(1):141-50.
2013: Jo-Hua Chiang; Shu-Jen Chang; Mann-Jen Hour; Tsung-Han Lee; Chi-Cheng Lu; Jai-Sing Yang; Jing-Gung Chung
Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.
Toxicology and applied pharmacology 2013;269(2):150-62.
2013: Mann-Jen Hour; Tai-Lin Chen; Kun-Tsung Lee; Chi-Yu Wu; Yang-Chang Wu; Bang-Jau You; Hong-Zin Lee
A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation.
Archives of toxicology 2013;87(5):835-46.
2012: Ta-Shu Song; Tai-Lin Chen; Yow-Wen Hsieh; Cheng-Hsiung Liu; Ching-Tien Peng; Mann-Jen Hour
Development of a fast LC-MS/MS assay for the determination of deferiprone in human plasma and application to pharmacokinetics.
Biomedical chromatography : BMC 2012;26(12):1575-81.
2012: Xiao-Feng Wang; Pei-Chi Wu; Kenneth F Bastow; Mann-Jen Hour; Rong Huang; Hsin-Yi Hung; William P Janzen; Jian Jin; Kuo-Hsiung Lee; Yi-Nan Liu; Susan L Morris-Natschke; Emika Ohkoshi; Keduo Qian; Bingjie Qin; Xing-Tao Tian; Lan Xie
Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents.
Bioorganic & medicinal chemistry letters 2012;22(19):6224-8.
2012: Chi-Cheng Lu; Kung-Wen Lu; Nou-Ying Tang; Jai-Sing Yang; Sakae Amagaya; Jo-Hua Chiang; Mann-Jen Hour; Tsung-Han Lee; Jing-Pin Lin; Jing-Gung Chung
Inhibition of invasion and migration by newly synthesized quinazolinone MJ-29 in human oral cancer CAL 27 cells through suppression of MMP-2/9 expression and combined down-regulation of MAPK and AKT signaling.
Anticancer research 2012;32(7):2895-903.
2012: Chi-Cheng Lu; Minoru Tsuzuki; Jai-Sing Yang; Jo-Hua Chiang; Mann-Jen Hour; Wen-Wen Huang; Tsung-Han Lee; Jen-Jyh Lin; Kuei-Li Lin; Jing-Gung Chung
Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice.
PloS one 2012;7(5):e36831.
2011: Kuan-Tin Chen; Yu-Jen Chiu; Yi-Hsuan Chuang; Jing-Gung Chung; Mann-Jen Hour; Sheng-Chu Kuo; Chi-Cheng Lu; Shih-Chang Tsai; Jai-Sing Yang
The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
International journal of oncology 2011;39(3):611-9.
2011: Yang C Wu; Yu H Chang; Mann-Jen Hour; Wing C Leung; Wen Z Liu; Chi Y Wu; Hong-Zin Lee
2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubules and the cell cycle.
The Journal of pharmacology and experimental therapeutics 2011;338(3):942-51.
2011: Yu-Jen Chiu; Jing-Gung Chung; Mann-Jen Hour; Wen-Wen Huang; Yi-An Jin; Sheng-Chu Kuo; Chi-Cheng Lu; Hui-Jye Chen; Jai-Sing Yang
Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011;29(9):1448-56.
2011: Mann-Jen Hour; Jai-Sing Yang; Tai-Lin Chen; Kuan-Tin Chen; Sheng-Chu Kuo; Jing-Gung Chung; Chi-Cheng Lu; Chia-Yi Chen; Yi-Hsuan Chuang
The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells.
European journal of medicinal chemistry 2011;46(7):2709-21.
2010: Yuk-Man Leung; Yi-Huan Tsou; Chang-Shin Kuo; Shang-Ying Lin; Pau-Yen Wu; Mann-Jen Hour; Yueh-Hsiung Kuo
Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated K+ channels.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2010;18(1):46-51.
2010: Hong-Zin Lee; Wen-Hui Yang; Mann-Jen Hour; Chi-Yu Wu; Wen-Huang Peng; Bo-Ying Bao; Ping-Hsiu Han; Da-Tian Bau
Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis.
European journal of pharmacology 2010;648(1-3):50-8.
2010: Jai-Sing Yang; Mann-Jen Hour; Wen-Wen Huang; Kuei-Li Lin; Sheng-Chu Kuo; Jing-Gung Chung
MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.
The Journal of pharmacology and experimental therapeutics 2010;334(2):477-88.
2008: Jin-Cherng Lien; Chi-Rei Wu; Mann-Jen Hour; Li-Jiau Huang; Tur-Fu Huang; Sheng-Chu Kuo
Synthesis of 2,3-disubstituted 1,4-naphthoquinones as antiplatelet agents.
Archiv der Pharmazie 2008;341(10):639-44.
2008: Chia-Chia Chao; Jeffrey Shieh; Sheng-Chu Kuo; Bor-Tsang Wu; Mann-Jen Hour; Yuk M Leung
HMJ-53A accelerates slow inactivation gating of voltage-gated K+ channels in mouse neuroblastoma N2A cells.
Neuropharmacology 2008;54(7):1128-35.
2007: Miao-Ying Lai; Mann-Jen Hour; Henry Wing-Cheung Leung; Wen-Hui Yang; Hong-Zin Lee
Chaperones are the target in aloe-emodin-induced human lung nonsmall carcinoma H460 cell apoptosis.
European journal of pharmacology 2007;573(1-3):1-10.
2007: Henry W C Leung; C-J Lin; Mann-Jen Hour; Wen-Hui Yang; M-Y Wang; Hong-Zin Lee
Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(10):2005-13.
2004: Jai-Sing Yang; Mann-Jen Hour; Sheng-Chu Kuo; Li-Jiau Huang; Miau-Rong Lee
Selective induction of G2/M arrest and apoptosis in HL-60 by a potent anticancer agent, HMJ-38.
Anticancer research 2004;24(3a):1769-78.
2001: T C Ko; Mann-Jen Hour; J C Lien; Che-Ming Teng; Kuo-Hsiung Lee; Sheng-Chu Kuo; Li-Jiau Huang
Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.
Bioorganic & medicinal chemistry letters 2001;11(3):279-82.
2000: Mann-Jen Hour; Li-Jiau Huang; Sheng-Chu Kuo; Y Xia; Kenneth F Bastow; Y Nakanishi; E Hamel; Kuo-Hsiung Lee
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Journal of medicinal chemistry 2000;43(23):4479-87.