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Raymond Houssin

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Jamal El Bakali; Frédérique Klupsch; Aurore Guédin; Bertrand BRASSART; Gaëlle Fontaine; Amaury Farce; Pascal Roussel; Raymond Houssin; Jean-Luc Bernier; Philippe CHAVATTE; Jean-Louis Mergny; Jean-François Riou; Jean-Pierre Hénichart
2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
Pauline Gilleron; Nicolas Wlodarczyk; Raymond Houssin; Amaury Farce; Guillaume Laconde; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Jean-Pierre Hénichart; Régis Millet
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.
Frédérique Klupsch; Raymond Houssin; Luc Humbert; Michel Imbenotte; Jean-Pierre Hénichart; Michel Lhermitte
Major metabolites of zolpidem: expeditious synthesis and mass spectra.

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All Publications

2009: Jamal El Bakali; Frédérique Klupsch; Aurore Guédin; Bertrand BRASSART; Gaëlle Fontaine; Amaury Farce; Pascal Roussel; Raymond Houssin; Jean-Luc Bernier; Philippe CHAVATTE; Jean-Louis Mergny; Jean-François Riou; Jean-Pierre Hénichart
2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
Bioorganic & medicinal chemistry letters 2009;19(13):3434-8.
2007: Pauline Gilleron; Nicolas Wlodarczyk; Raymond Houssin; Amaury Farce; Guillaume Laconde; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Jean-Pierre Hénichart; Régis Millet
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(19):5465-71.
2006: Frédérique Klupsch; Raymond Houssin; Luc Humbert; Michel Imbenotte; Jean-Pierre Hénichart; Michel Lhermitte
Major metabolites of zolpidem: expeditious synthesis and mass spectra.
Chemical & pharmaceutical bulletin 2006;54(9):1318-21.
2006: Pauline Gilleron; Régis Millet; Raymond Houssin; Nicolas Wlodarczyk; Amaury Farce; Amélie Lemoine; Jean-François Goossens; Philippe CHAVATTE; Nicole Pommery; Jean-Pierre Hénichart
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds.
European journal of medicinal chemistry 2006;41(6):745-55.
2006: Pauline Gilleron; Régis Millet; Juozas Domarkas; Amaury Farce; Raymond Houssin; Jean-Pierre Hénichart
Synthesis of a novel conformationally restricted Val-Phe dipeptidomimetic.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(2):140-6.
2005: Adina Ryckebusch; Pauline Gilleron; Régis Millet; Raymond Houssin; Amélie Lemoine; Nicole Pommery; Philippe Grellier; Christian Sergheraert; Jean-Pierre Hénichart
Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity.
Chemical & pharmaceutical bulletin 2005;53(10):1324-6.
2005: Nicolas Wlodarczyk; Pauline Gilleron; Régis Millet; Raymond Houssin; Jean-François Goossens; Amélie Lemoine; Nicole Pommery; Ming X Wei; Jean-Pierre Hénichart
In vitro and in vivo evaluation of two rational-designed nonpeptidic farnesyltransferase inhibitors on HT29 human colon cancer cell lines.
Oncology research 2005;16(3):107-18.
2004: Régis Millet; Juozas Domarkas; Raymond Houssin; Pauline Gilleron; Jean-François Goossens; Philippe CHAVATTE; Cédric Logé; Nicole Pommery; Jean Pommery; Jean-Pierre Hénichart
Potent and selective farnesyl transferase inhibitors.
Journal of medicinal chemistry 2004;47(27):6812-20.
2004: Nicole Pommery; Thierry Taverne; Aurélie Telliez; Laurence Goossens; Caroline Charlier; Jean Pommery; Jean-François Goossens; Raymond Houssin; François Durant; Jean-Pierre Hénichart
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Journal of medicinal chemistry 2004;47(25):6195-206.
2004: Sarah Catoen-Chackal; Michaël Facompré; Raymond Houssin; Nicole Pommery; Jean-François Goossens; Pierre Colson; Christian Bailly; Jean-Pierre Hénichart
DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal of medicinal chemistry 2004;47(14):3665-73.
2004: Aurore Perzyna; Frédérique Klupsch; Raymond Houssin; Nicole Pommery; Amélie Lemoine; Jean-Pierre Hénichart
New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents.
Bioorganic & medicinal chemistry letters 2004;14(9):2363-5.
2004: Natacha Malecki; Pascal Carato; Benoît Rigo; Jean-François Goossens; Raymond Houssin; Christian Bailly; Jean-Pierre Hénichart
Synthesis of condensed quinolines and quinazolines as DNA ligands.
Bioorganic & medicinal chemistry 2004;12(3):641-7.
2003: Aurore Perzyna; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Carine Marty; Michaël Facompré; Pierre Colson; Claude Houssier; Christian Bailly; Jean-Pierre Hénichart
Indolizino[1,2-b]quinolines derived from A-D rings of camptothecin: synthesis and DNA interaction.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):101-9.
2003: Sarah Chackal; Raymond Houssin; Nicole Pommery; Jean-Pierre Henichart
Design, synthesis and pharmacological evaluation of new anticancer fused pentacycles.
Journal of enzyme inhibition and medicinal chemistry 2003;18(2):95-9.
2003: Sarah Chackal; Michaël Facompré; Raymond Houssin; Jean-François Goossens; Nicole Pommery; Jean-Pierre Hénichart; Christian Bailly
Highly cytotoxic benzo[c]pyrido[2,3,4-kl]acridines.
Bioorganic & medicinal chemistry letters 2003;13(5):943-6.
2002: Aurore Perzyna; Carine Marty; Michaël Facompré; Jean-François Goossens; Nicole Pommery; Pierre Colson; Claude Houssier; Raymond Houssin; Jean-Pierre Hénichart; Christian Bailly
Formaldehyde-induced DNA cross-link of indolizino[1,2-b]quinolines derived from the A-D rings of camptothecin.
Journal of medicinal chemistry 2002;45(26):5809-12.
2002: Bertrand Le Bourdonnec; Christine Cauvin; Emmanuelle Meulon; Saïd Yous; Jean-François Goossens; François Durant; Raymond Houssin; Jean-Pierre Hénichart
Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.
Journal of medicinal chemistry 2002;45(21):4794-8.
2002: Régis Millet; Juozas Domarkas; Benoît Rigo; Laurence Goossens; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Novel potent substance P and neurokinin A receptor antagonists. Conception, synthesis and biological evaluation of indolizine derivatives.
Bioorganic & medicinal chemistry 2002;10(9):2905-12.
2002: Axel Couture; Pierre Grandclaudon; Christophe Hoarau; Joséphine Cornet; Jean-Pierre Hénichart; Raymond Houssin
Metalation of 4-oxazolinyloxazole derivatives. A convenient route to 2,4-bifunctionalized oxazoles.
The Journal of organic chemistry 2002;67(11):3601-6.
2002: Sarah Chackal; Raymond Houssin; Jean-Pierre Hénichart
An efficient synthesis of the new benzo[c]pyrido[2,3,4-kl]acridine skeleton.
The Journal of organic chemistry 2002;67(10):3502-5.
2002: Sabine Barbey; Laurence Goossens; Thierry Taverne; Joséphine Cornet; Valérie Choesmel; Céline Rouaud; Gilles Gimeno; Sylvie Yannic-Arnoult; Catherine Michaux; Caroline Charlier; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Bioorganic & medicinal chemistry letters 2002;12(5):779-82.
2002: Raymond Houssin; Jean Pommery; Marie-Catherine Salaün; Sophie Duban-Deweer; Jean-François Goossens; Philippe CHAVATTE; Jean-Pierre Hénichart
Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.
Journal of medicinal chemistry 2002;45(2):533-6.
2001: Régis Millet; Laurence Goossens; K Bertrand-Caumont; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
A flexible approach to the design of new potent substance P receptor ligands.
The Journal of pharmacy and pharmacology 2001;53(7):929-34.
2001: Régis Millet; Laurence Goossens; Jean-François Goossens; Philippe CHAVATTE; K Bertrand-Caumont; Raymond Houssin; Jean-Pierre Hénichart
Conformation of the tripeptide Cbz-Pro-Leu-Trp-OBzl(CF3)2 deduced from two-dimensional 1H-NMR and conformational energy calculations is related to its affinity for NK1-receptor.
Journal of peptide science : an official publication of the European Peptide Society 2001;7(6):323-30.
2001: Jean-François Goossens; E Bouey-Bencteux; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; William Laine; Brigitte Baldeyrou; Christian Bailly
DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Biochemistry 2001;40(15):4663-71.
2001: C Audouin; N Mestdagh; Marie-Agnès Lassoie; Raymond Houssin; Jean-Pierre Hénichart
N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.
Bioorganic & medicinal chemistry letters 2001;11(6):845-8.
2000: Bertrand Le Bourdonnec; E Meulon; Saïd Yous; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists.
Journal of medicinal chemistry 2000;43(14):2685-97.
2000: F Dudouit; Jean-François Goossens; Raymond Houssin; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier; N Gelus; Christian Bailly
Synthesis, DNA binding, topoisomerases inhibition and cytotoxic properties of 4-arylcarboxamidopyrrolo-2-carboxyanilides.
Bioorganic & medicinal chemistry letters 2000;10(6):553-7.
1999: M O Catrycke; Raymond Houssin; Jean-Pierre Hénichart; B Pfeiffer; Pierre Renard; Laurent Dassonneville; Christian Bailly
Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II.
Bioorganic & medicinal chemistry letters 1999;9(14):2025-30.
1998: E Bouey-Bencteux; C Loison; Nicole Pommery; Raymond Houssin; Jean-Pierre Hénichart
Synthesis and antiproliferative properties of 4-aminoquinazoline derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.
Anti-cancer drug design 1998;13(8):893-922.
1996: K D Asmus; René V Bensasson; Jean-Luc Bernier; Raymond Houssin; E J Land
One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C.
The Biochemical journal 1996;315 ( Pt 2)():625-9.
1995: Bertrand Plouvier; Raymond Houssin; Nicole Helbecque; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Christian Bailly
Influence of the methyl substituents of a thiazole-containing lexitropsin on the mode of binding to DNA.
Anti-cancer drug design 1995;10(2):155-66.
1995: S Goldstein; M Neuwels; M A Lassoie; Raymond Houssin; K Caumont; E Differding; J P Henichart
[Conformational analysis of peptide antagonists in the design of pseudopeptide and non-peptide antagonists].
Journal de pharmacie de Belgique 1995;50(2-3):213-22.
1994: Bertrand Plouvier; Raymond Houssin; B Hecquet; Pierre Colson; Claude Houssier; M J Waring; Jean-Pierre Hénichart; Christian Bailly
Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.
Bioconjugate chemistry 1994;5(5):475-81.
1994: A Kénani; C Bailly; Raymond Houssin; Jean-Pierre Hénichart
Comparative subcellular distribution of the copper complexes of bleomycin-A2 and deglycobleomycin-A2.
Anti-cancer drugs 1994;5(2):199-201.
1992: Christian Bailly; P Colson; Claude Houssier; Raymond Houssin; D Mrani; Gilles Gosselin; Jean-Louis Imbach; M J Waring; J W Lown; Jean-Pierre Hénichart
Binding properties and DNA sequence-specific recognition of two bithiazole-linked netropsin hybrid molecules.
Biochemistry 1992;31(35):8349-62.
1992: Christian Bailly; C O'Huigin; Raymond Houssin; Pierre Colson; Claude Houssier; C Rivalle; Emile Bisagni; J P Henichart; Michael J Waring
DNA-binding properties of a distamycin-ellipticine hybrid molecule.
Molecular pharmacology 1992;41(5):845-55.
1991: Bertrand Plouvier; Christian Bailly; Raymond Houssin; K E Rao; W J Lown; Jean-Pierre Hénichart; M J Waring
DNA-sequence specific recognition by a thiazole analogue of netropsin: a comparative footprinting study.
Nucleic acids research 1991;19(21):5821-9.
1989: Christian Bailly; Nicole Pommery; Raymond Houssin; J P Henichart
Design, synthesis, DNA binding, and biological activity of a series of DNA minor-groove-binding intercalating drugs.
Journal of pharmaceutical sciences 1989;78(11):910-7.
1989: E Morier-Teissier; Christian Bailly; Jean-Luc Bernier; Raymond Houssin; Nicole Helbecque; Jean Pierre Catteau; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart
Synthesis, biological activity and DNA interaction of anilinoacridine and bithiazole peptide derivatives related to the anti-tumor drugs m-AMSA and bleomycin.
Anti-cancer drug design 1989;4(1):37-52.
1989: Christian Bailly; Raymond Houssin; Jean-Luc Bernier; J P Henichart
[Interaction of bleomycin with the plasmid membrane: changes in the fluidity and peroxidation of lipids].
Bulletin du cancer 1989;76(8):835-7.
1988: A Kénani; C Bailly; Nicole Helbecque; Jean Pierre Catteau; Raymond Houssin; Jean-Luc Bernier; Jean-Pierre Hénichart
The role of the gulose-mannose part of bleomycin in activation of iron-molecular oxygen complexes.
The Biochemical journal 1988;253(2):497-504.
1988: Christian Bailly; A Kenani; Nicole Helbecque; Jean-Luc Bernier; Raymond Houssin; Jean-Pierre Hénichart
DNA-binding and DNA-cleaving properties of a synthetic model AGAGLU related to the antitumour drugs AMSA and bleomycin.
Biochemical and biophysical research communications 1988;152(2):695-702.
1987: C Bailly; Jean Pierre Catteau; Nicole Helbecque; Jean-Luc Bernier; Raymond Houssin; C Denis; Jean-Pierre Hénichart
Complexation of copper(II) by a peptide hybrid of bleomycin and amsacrine. Circular dichroism and electron spin resonance studies.
Journal of inorganic biochemistry 1987;31(3):211-20.
1987: A Kenani; M Lohez; Raymond Houssin; Nicole Helbecque; Jean-Luc Bernier; P Lemay; Jean-Pierre Hénichart
Chelating, DNA-binding and DNA-cleaving properties of a synthetic model for bleomycin.
Anti-cancer drug design 1987;2(1):47-59.
1987: C Bailly; Jean-Luc Bernier; Raymond Houssin; Nicole Helbecque; Jean-Pierre Hénichart
Design of two metal-chelating, DNA-binding models: molecular combinations of bleomycin and amsacrine anti-tumour drugs.
Anti-cancer drug design 1987;1(4):303-12.
1986: Raymond Houssin; Nicole Helbecque; Jean-Luc Bernier; J P Henichart
A new bithiazole derivative with intercalative properties.
Journal of biomolecular structure & dynamics 1986;4(2):219-29.
1986: Jean-Luc Bernier; A Kenani; Raymond Houssin; Nicole Helbecque; M Lohez; B Hecquet; Jean-Pierre Hénichart
Molecular interaction between bleomycin and amsacrine in the presence of cupric ions.
Journal of inorganic biochemistry 1986;27(4):271-85.
1985: Jean-Pierre Hénichart; Jean-Luc Bernier; Nicole Helbecque; Raymond Houssin
Is the bithiazole moiety of bleomycin a classical intercalator?
Nucleic acids research 1985;13(18):6703-17.
1985: Jean-Pierre Hénichart; Jean-Luc Bernier; Raymond Houssin; M Lohez; A Kenani; Jean Pierre Catteau
Copper(II)- and iron(II)-complexes of methyl 2-(2-aminoethyl)-aminomethyl-pyridine-6-carboxyl-histidinate (AMPHIS), a peptide mimicking the metal-chelating moiety of bleomycin. An ESR investigation.
Biochemical and biophysical research communications 1985;126(3):1036-41.
1985: J P Henichart; B Carette; Jean-Luc Bernier; Raymond Houssin
Opiate receptor interaction of a new analgesic drug 2-piperidinoethyl dibenzylglycolate.
Chemico-biological interactions 1985;53(1-2):77-87.
1984: J P Henichart; Jean-Luc Bernier; P Lemay; Raymond Houssin; Jean Pierre Catteau
Subcellular distribution of spin-labeled bithiazoles and bleomycin in living KB cells: an ESR study.
Cancer biochemistry biophysics 1984;7(3):239-44.
1981: J P Hénichart; Raymond Houssin; C Gors; F Baert
Conformational analysis of a new analgesic triazolinethione. Structural comparisons with antipyrine.
Molecular pharmacology 1981;20(3):598-601.
1981: J P Hénichart; Raymond Houssin
Structure and antiarrhythmic activity of three ketophosphonium salts.
Experientia 1981;37(3):299-301.
1980: Raymond Houssin; Jean-Pierre Hénichart; M Foulon; F Baert
Structure-neuromuscular blocking activity relationships of ketophosphonium salts.
Journal of pharmaceutical sciences 1980;69(8):888-91.