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Pamela Howorth

Research Profile

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Combinatorial Chemistry Techniques

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Publications

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Douglas E Wilkinson; Bert Thomas; David C Limburg; Agnes Holmes; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hong Guo; Pamela Howorth; Heather Valentine; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton; Yong-Qian Wu
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects.
Yong-Qian Wu; Douglas E Wilkinson; David C Limburg; Jia-He Li; Hansjorg Sauer; Doug Ross; Shi Liang; Dawn Spicer; Heather Valentine; Mike Fuller; Hong Guo; Pamela Howorth; Raj Soni; Yi Chen; Joseph P Steiner; Gregory S Hamilton
Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands.
Gregory S Hamilton; Yong-Qian Wu; David C Limburg; Douglas E Wilkinson; Mark Vaal; Jia-He Li; Christine Thomas; Wei Huang; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hongshi Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner
Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.

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All Publications

2003: Douglas E Wilkinson; Bert Thomas; David C Limburg; Agnes Holmes; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hong Guo; Pamela Howorth; Heather Valentine; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton; Yong-Qian Wu
Synthesis, molecular modeling and biological evaluation of aza-proline and aza-pipecolic derivatives as FKBP12 ligands and their in vivo neuroprotective effects.
Bioorganic & medicinal chemistry 2003;11(22):4815-25.
2002: Yong-Qian Wu; Douglas E Wilkinson; David C Limburg; Jia-He Li; Hansjorg Sauer; Doug Ross; Shi Liang; Dawn Spicer; Heather Valentine; Mike Fuller; Hong Guo; Pamela Howorth; Raj Soni; Yi Chen; Joseph P Steiner; Gregory S Hamilton
Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands.
Journal of medicinal chemistry 2002;45(16):3558-68.
2002: Gregory S Hamilton; Yong-Qian Wu; David C Limburg; Douglas E Wilkinson; Mark Vaal; Jia-He Li; Christine Thomas; Wei Huang; Hansjorg Sauer; Douglas T Ross; Raj Soni; Yi Chen; Hongshi Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner
Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.
Journal of medicinal chemistry 2002;45(16):3549-57.
2002: Ling Wei; Yon- Qian Wu; Douglas E Wilkinson; Yi Chen; Raj Soni; Chad Scott; Douglas T Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton
Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.
Bioorganic & medicinal chemistry letters 2002;12(10):1429-33.
2002: Chi Choi; Jia-He Li; Mark Vaal; Christine Thomas; David C Limburg; Yong-Qian Wu; Yi Chen; Raj Soni; Chad Scott; Douglas T Ross; Hong Guo; Pamela Howorth; Heather Valentine; Shi Liang; Dawn Spicer; Mike Fuller; Joseph P Steiner; Gregory S Hamilton
Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(10):1421-8.
2001: Douglas T Ross; Hong Guo; Pamela Howorth; Yi Chen; Gregory S Hamilton; Joseph P Steiner
The small molecule FKBP ligand GPI 1046 induces partial striatal re-innervation after intranigral 6-hydroxydopamine lesion in rats.
Neuroscience letters 2001;297(2):113-6.
1997: Joseph P Steiner; Gregory S Hamilton; Douglas T Ross; Heather Valentine; Hong Guo; M A Connolly; Shi Liang; C Ramsey; Jia-He Li; W Huang; Pamela Howorth; Raj Soni; Mike Fuller; Hansjorg Sauer; A C Nowotnik; PD Suzdak
Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):2019-24.