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James Hoxie

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James W Curran; James A Hoxie
Translating social and behavioral science research to the AIDS epidemic: a center for AIDS research perspective.
Matthew W Breed; Daniel C Douek; Beth Haggarty; James A Hoxie; Andrea P O Jordan; Brandon F Keele; Marcelo J Kuroda; Cornelis F Lichtveld; Jeffrey D Lifson; Cecily C Midkiff; Bapi Pahar; Michael Piatak; Netanya G Sandler; Faith R Schiro; Chie Sugimoto; Xavier Alvarez; Pyone Aye; Andrew A Lackner
Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
James A Hoxie; Carl H June
Novel cell and gene therapies for HIV.

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All Publications

2013: James W Curran; James A Hoxie
Translating social and behavioral science research to the AIDS epidemic: a center for AIDS research perspective.
Journal of acquired immune deficiency syndromes (1999) 2013;63 Suppl 1():S4-5.
2013: Matthew W Breed; Daniel C Douek; Beth Haggarty; James A Hoxie; Andrea P O Jordan; Brandon F Keele; Marcelo J Kuroda; Cornelis F Lichtveld; Jeffrey D Lifson; Cecily C Midkiff; Bapi Pahar; Michael Piatak; Netanya G Sandler; Faith R Schiro; Chie Sugimoto; Xavier Alvarez; Pyone Aye; Andrew A Lackner
Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
Journal of virology 2013;87(3):1528-43.
2012: James A Hoxie; Carl H June
Novel cell and gene therapies for HIV.
Cold Spring Harbor perspectives in medicine 2012;2(10):.
2011: Justin Pollara; Mario Roederer; Georgia D Tomaras; Kent J Weinhold; Faraha Brewer; Lydia Hart; Barton F Haynes; James A Hoxie; Ying Huang; John C Kappes; Akira Komoriya; David C Montefiori; Christina Ochsenbauer; Beverly Z Packard; Joy Pickeral; Guido Ferrari
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011;79(8):603-12.
2011: Guido Ferrari; Stephanie Freel; Tiara Harms; S Munir Alam; Mark Drinker; James A Hoxie; John C Kappes; Daniel Kozink; M Anthony Moody; Christina Ochsenbauer; Justin Pollara; James E Robinson; George M Shaw; Georgia D Tomaras; Barton F Haynes
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.
Journal of virology 2011;85(14):7029-36.
2011: Craig B Wilen; Jianbin Wang; John C Tilton; Jeffrey C Miller; Kenneth A Kim; Edward J Rebar; Scott A Sherrill-Mix; Sean C Patro; Anthony J Secreto; Andrea P O Jordan; Gary Lee; Joshua Kahn; Pyone Aye; Bruce A Bunnell; Andrew A Lackner; James A Hoxie; Gwenn A Danet-Desnoyers; Frederic D Bushman; James L Riley; Philip D Gregory; Carl H June; Michael C Holmes; Robert W Doms
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.
PLoS pathogens 2011;7(4):e1002020.
2010: Gregory Q Del Prete; George J Leslie; Beth Haggarty; Andrea P O Jordan; Josephine Romano; James A Hoxie
Distinct molecular pathways to X4 tropism for a V3-truncated human immunodeficiency virus type 1 lead to differential coreceptor interactions and sensitivity to a CXCR4 antagonist.
Journal of virology 2010;84(17):8777-89.
2010: James A Hoxie
Toward an antibody-based HIV-1 vaccine.
Annual review of medicine 2010;61():135-52.
2009: Caroline Agrawal-Gamse; Fang-Hua Lee; Beth Haggarty; Andrea P O Jordan; Yanjie Yi; Benhur Lee; Ronald G Collman; James A Hoxie; Robert W Doms; Meg M Laakso
Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
Journal of virology 2009;83(21):11005-15.
2009: Gregory Q Del Prete; Beth Haggarty; George J Leslie; Andrea P O Jordan; Josephine Romano; Nathaniel Wang; Jianbin Wang; Michael C Holmes; David C Montefiori; James A Hoxie
Derivation and characterization of a simian immunodeficiency virus SIVmac239 variant with tropism for CXCR4.
Journal of virology 2009;83(19):9911-22.
2009: Lan Wu; Tongqing Zhou; Zhi-Yong Yang; Krisha Svehla; Sijy O'Dell; Mark K Louder; Ling Xu; John R Mascola; Dennis R Burton; James A Hoxie; Robert W Doms; Peter D Kwong; Gary Nabel
Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain.
Journal of virology 2009;83(10):5077-86.
2009: Katrina M Nolan; Gregory Q Del Prete; Andrea P O Jordan; Beth Haggarty; Josephine Romano; George J Leslie; James A Hoxie
Characterization of a human immunodeficiency virus type 1 V3 deletion mutation that confers resistance to CCR5 inhibitors and the ability to use aplaviroc-bound receptor.
Journal of virology 2009;83(8):3798-809.
2009: Katie L Davis; Frederic Bibollet-Ruche; Hui Li; Julie M Decker; Olaf Kutsch; Lynn Morris; Aidy Salomon; Abraham Pinter; James A Hoxie; Beatrice H Hahn; Peter D Kwong; George M Shaw
Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma.
Journal of virology 2009;83(3):1240-59.
2009: Yuxing Li; Krisha Svehla; Mark K Louder; Diane Wycuff; Sanjay Phogat; Min Tang; Stephen A Migueles; Xueling Wu; Adhuna Phogat; George M Shaw; Mark Connors; James A Hoxie; John R Mascola; Richard Wyatt
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals.
Journal of virology 2009;83(2):1045-59.
2008: Emma T Crooks; Pengfei Jiang; Michael Franti; Sharon Wong; Michael B Zwick; James A Hoxie; James E Robinson; Penny L Moore; James M Binley
Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization.
Virology 2008;377(2):364-78.
2008: Anthony Fauci; Margaret I Johnston; Carl W Dieffenbach; Dennis R Burton; Scott M Hammer; James A Hoxie; Malcolm Martin; Julie Overbaugh; David Ian Watkins; Adel Mahmoud; Warner Greene
HIV vaccine research: the way forward.
Science (New York, N.Y.) 2008;321(5888):530-2.
2008: Katrina M Nolan; Andrea P O Jordan; James A Hoxie
Effects of partial deletions within the human immunodeficiency virus type 1 V3 loop on coreceptor tropism and sensitivity to entry inhibitors.
Journal of virology 2008;82(2):664-73.
2007: George Lin; Andrea Bertolotti-Ciarlet; Beth Haggarty; Josephine Romano; Katrina M Nolan; George J Leslie; Andrea P O Jordan; Chih-chin Huang; Peter D Kwong; Robert W Doms; James A Hoxie
Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.
Journal of virology 2007;81(18):9956-66.
2007: Meg M Laakso; Fang-Hua Lee; Beth Haggarty; Caroline Agrawal; Katrina M Nolan; Mark J Biscone; Josephine Romano; Andrea P O Jordan; George J Leslie; Eric G Meissner; Lishan Su; James A Hoxie; Robert W Doms
V3 loop truncations in HIV-1 envelope impart resistance to coreceptor inhibitors and enhanced sensitivity to neutralizing antibodies.
PLoS pathogens 2007;3(8):e117.
2007: James A Hoxie; Veronica Miller; Bruce Walker
Tuberculosis and HIV coinfection: genesis of the supplement and sponsors' contribution.
The Journal of infectious diseases 2007;196 Suppl 1():S4.
2007: Kathy Fernando; Haitao Hu; Houping Ni; James A Hoxie; Drew Weissman
Vaccine-delivered HIV envelope inhibits CD4(+) T-cell activation, a mechanism for poor HIV vaccine responses.
Blood 2007;109(6):2538-44.
2007: Rahel Byland; Patricia J Vance; James A Hoxie; Mark Marsh
A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein.
Molecular biology of the cell 2007;18(2):414-25.
2006: Chawaree Chaipan; Elizabeth J Soilleux; Peter Simpson; Heike Hofmann; Thomas Gramberg; Andrea Marzi; Martina Geier; Elizabeth A Stewart; Jutta Eisemann; Alexander Steinkasserer; Katsue Suzuki-Inoue; Gemma L Fuller; Andrew C Pearce; Steve P Watson; James A Hoxie; Frédéric Baribaud; Stefan Pöhlmann
DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets.
Journal of virology 2006;80(18):8951-60.
2006: Qing Wei; Jackie Stallworth; Patricia J Vance; James A Hoxie; Patricia N Fultz
Simian immunodeficiency virus (SIV)/immunoglobulin G immune complexes in SIV-infected macaques block detection of CD16 but not cytolytic activity of natural killer cells.
Clinical and vaccine immunology : CVI 2006;13(7):768-78.
2005: Stéphanie Wyss; Antony S Dimitrov; Frédéric Baribaud; Terri G Edwards; Robert Blumenthal; James A Hoxie
Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.
Journal of virology 2005;79(19):12231-41.
2005: George Lin; Samuel L Murphy; Glen N Gaulton; James A Hoxie
Modification of a viral envelope glycoprotein cell-cell fusion assay by utilizing plasmid encoded bacteriophage RNA polymerase.
Journal of virological methods 2005;128(1-2):135-42.
2005: Melissa D Sánchez; Theodore C Pierson; Douglas McAllister; Sheri L Hanna; Bridget A Puffer; Laura E Valentine; Mariam M Murtadha; James A Hoxie; Robert W Doms
Characterization of neutralizing antibodies to West Nile virus.
Virology 2005;336(1):70-82.
2005: Julie M Decker; Frederic Bibollet-Ruche; Xiping Wei; shuyi wang; David N Levy; Wenquan Wang; Eric Delaporte; Martine Peeters; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Michael S Saag; James A Hoxie; Beatrice H Hahn; Peter D Kwong; James E Robinson; George M Shaw
Antigenic conservation and immunogenicity of the HIV coreceptor binding site.
The Journal of experimental medicine 2005;201(9):1407-19.
2005: Margaret J Hosie; Dieter Klein; James M Binley; Thomas H Dunsford; Oswald Jarrett; James C Neil; Elzbieta Knapp; Simone Giannecchini; Donatella Matteucci; Mauro Bendinelli; James A Hoxie; Brian J Willett
Vaccination with an inactivated virulent feline immunodeficiency virus engineered to express high levels of Env.
Journal of virology 2005;79(3):1954-7.
2004: Dennis R Burton; Ronald C Desrosiers; Robert W Doms; Mark B Feinberg; Robert C Gallo; Beatrice Hahn; James A Hoxie; Eric Hunter; Bette Korber; Alan Landay; Michael M Lederman; Judy Lieberman; Joseph M McCune; John P Moore; Neal Nathanson; Louis J Picker; Douglas Richman; Charles Rinaldo; Mario Stevenson; David Ian Watkins; Steven M Wolinsky; Jerome A Zack
Public health. A sound rationale needed for phase III HIV-1 vaccine trials.
Science (New York, N.Y.) 2004;303(5656):316.
2003: George Lin; James A Hoxie
CCR5 mimicry by sulfated human anti-HIV-1 antibodies.
Cell 2003;114(2):147-8.
2003: George Lin; Graham Simmons; Stefan Pöhlmann; Frédéric Baribaud; Houping Ni; George J Leslie; Beth Haggarty; Paul Bates; Drew Weissman; James A Hoxie; Robert W Doms
Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.
Journal of virology 2003;77(2):1337-46.
2003: George Lin; Frédéric Baribaud; Josephine Romano; Robert W Doms; James A Hoxie
Identification of gp120 binding sites on CXCR4 by using CD4-independent human immunodeficiency virus type 2 Env proteins.
Journal of virology 2003;77(2):931-42.
2002: Elena Chertova; Julian W Bess; Bruce J Crise; Raymond C Sowder II; Terra M Schaden; Joanne M Hilburn; James A Hoxie; Raoul E Benveniste; Jeffrey D Lifson; Louis E. Henderson; Larry O Arthur
Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus.
Journal of virology 2002;76(11):5315-25.
2002: Jie Liu; Shilong Wang; James A Hoxie; Celia C LaBranche; Min Lu
Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex.
The Journal of biological chemistry 2002;277(15):12891-900.
2002: Terri G Edwards; Stéphanie Wyss; Jacqueline D Reeves; Susan Zolla-Pazner; James A Hoxie; Robert W Doms; Frédéric Baribaud
Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein.
Journal of virology 2002;76(6):2683-91.
2002: Lena Al-Harthi; Larry J Guilbert; James A Hoxie; Alan Landay
Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.
AIDS research and human retroviruses 2002;18(1):13-7.
2001: George Lin; Benhur Lee; Beth Haggarty; Robert W Doms; James A Hoxie
CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain.
Journal of virology 2001;75(22):10766-78.
2001: Frédéric Baribaud; Stefan Pöhlmann; Tim D. Sparwasser; M T Kimata; Y K Choi; Beth Haggarty; Navid Ahmad; Todd Macfarlan; Terri G Edwards; George J Leslie; J Arnason; T A Reinhart; J T Kimata; Dan R Littman; James A Hoxie; Robert W Doms
Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.
Journal of virology 2001;75(21):10281-9.
2001: Terri G Edwards; Trevor L Hoffman; Frédéric Baribaud; Stéphanie Wyss; Celia C LaBranche; Josephine Romano; J Adkinson; Matthew Sharron; James A Hoxie; Robert W Doms
Relationships between CD4 independence, neutralization sensitivity, and exposure of a CD4-induced epitope in a human immunodeficiency virus type 1 envelope protein.
Journal of virology 2001;75(11):5230-9.
2001: Patricia N Fultz; Patricia J Vance; M J Endres; Binli Tao; Jeffrey D Dvorin; Ian C Davis; J D Lifson; D C Montefiori; Mark Marsh; Michael H Malim; James A Hoxie
In vivo attenuation of simian immunodeficiency virus by disruption of a tyrosine-dependent sorting signal in the envelope glycoprotein cytoplasmic tail.
Journal of virology 2001;75(1):278-91.
2000: Aimee Edinger; M Ahuja; T Sung; K C Baxter; Beth Haggarty; Robert W Doms; James A Hoxie
Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein.
Journal of virology 2000;74(17):7922-35.
2000: K Bowers; Annegret Pelchen-Matthews; S Höning; Patricia J Vance; L Creary; Beth Haggarty; Josephine Romano; W Ballensiefen; James A Hoxie; Mark Marsh
The simian immunodeficiency virus envelope glycoprotein contains multiple signals that regulate its cell surface expression and endocytosis.
Traffic (Copenhagen, Denmark) 2000;1(8):661-74.
2000: M Molino; Marilyn J Woolkalis; Nicolas Prévost; D Praticó; Elliot S Barnathan; G Taraboletti; Beth Haggarty; Joseph Hesselgesser; Richard Horuk; James A Hoxie; Lawrence F Brass
CXCR4 on human endothelial cells can serve as both a mediator of biological responses and as a receptor for HIV-2.
Biochimica et biophysica acta 2000;1500(2):227-40.
1999: Celia C LaBranche; Trevor L Hoffman; Josephine Romano; Beth Haggarty; Terri G Edwards; TJ Matthews; Robert W Doms; James A Hoxie
Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.
Journal of virology 1999;73(12):10310-9.
1999: Trevor L Hoffman; Celia C LaBranche; Wei Zhang; Gabriela Canziani; J Robinson; Irwin Chaiken; James A Hoxie; Robert W Doms
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6359-64.
1999: Benjamin J Doranz; M J Orsini; JD Turner; Trevor L Hoffman; Joanne F Berson; James A Hoxie; Stephen Peiper; Lawrence F Brass; Robert W Doms
Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.
Journal of virology 1999;73(4):2752-61.
1998: James A Hoxie; Celia C LaBranche; MJ Endres; JD Turner; Joanne F Berson; Robert W Doms; TJ Matthews
CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2.
Journal of reproductive immunology 1998;41(1-2):197-211.
1998: Audrey L Kinter; AT Catanzaro; J Monaco; M Ruiz; J Shawn Justement; Susan Moir; James Arthos; A Oliva; Linda Ehler; SB Mizell; Robert Jackson; M Ostrowski; James A Hoxie; R Offord; Anthony Fauci
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11880-5.
1998: I Mondor; Maxime Moulard; S Ugolini; Per Johan Klasse; James A Hoxie; Ali Amara; Thierry Delaunay; Richard Wyatt; Joseph Sodroski; Quentin J Sattentau
Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.
Virology 1998;248(2):394-405.
1998: Nathalie Signoret; MM Rosenkilde; PJ Klasse; Thue W Schwartz; Michael H Malim; James A Hoxie; Mark Marsh
Differential regulation of CXCR4 and CCR5 endocytosis.
Journal of cell science 1998;111 ( Pt 18)():2819-30.
1998: T Hamada; R Möhle; Joseph Hesselgesser; James A Hoxie; RL Nachman; Malcolm A S Moore; Shahin Rafii
Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation.
The Journal of experimental medicine 1998;188(3):539-48.
1998: Brian J Willett; K Adema; Nikolaus Heveker; Anne Brelot; Laurent Picard; Marc Alizon; JD Turner; James A Hoxie; Stephen Peiper; James C Neil; Margaret J Hosie
The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus.
Journal of virology 1998;72(8):6475-81.
1998: M Agosto; J Allan; C Benson; E A Berger; R Blumenthal; D Burton; J Clements; J Coffin; R Connor; B Cullen; R Desrosiers; D Dimitrov; R Doms; M Emerman; Mark B Feinberg; Patricia N Fultz; C Gerard; G Gonsalves; A Haase; Nancy Haigwood; V Hirsch; D Ho; James A Hoxie; S L Hu; D Zingale
AIDS vaccine development.
Science (New York, N.Y.) 1998;280(5365):803, 804-5.
1998: Joseph Hesselgesser; D Taub; P Baskar; M Greenberg; James A Hoxie; Dennis L Kolson; Richard Horuk
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4.
Current biology : CB 1998;8(10):595-8.
1998: M Molino; Puthiyaveettil N Raghunath; Alice Kuo; M Ahuja; James A Hoxie; Lawrence F Brass; Elliot S Barnathan
Differential expression of functional protease-activated receptor-2 (PAR-2) in human vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(5):825-32.
1998: A Rubbert; Christophe Combadiere; M Ostrowski; James Arthos; Mark Dybul; Elizabeth Machado; M A Cohn; James A Hoxie; Philip M Murphy; Anthony Fauci; Drew Weissman
Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3933-41.
1998: Margaret J Hosie; N Broere; Joseph Hesselgesser; JD Turner; James A Hoxie; James C Neil; Brian J Willett
Modulation of feline immunodeficiency virus infection by stromal cell-derived factor.
Journal of virology 1998;72(3):2097-104.
1998: David C Montefiori; R G Collman; T R Fouts; JY Zhou; Miroslawa Bilska; James A Hoxie; JP Moore; Dani P Bolognesi
Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage.
Journal of virology 1998;72(3):1886-93.
1998: Joseph Hesselgesser; Meina Liang; James A Hoxie; M Greenberg; Lawrence F Brass; M J Orsini; D Taub; Richard Horuk
Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):877-83.
1997: H Moriuchi; M Moriuchi; James Arthos; James A Hoxie; Anthony Fauci
Promonocytic U937 subclones expressing CD4 and CXCR4 are resistant to infection with and cell-to-cell fusion by T-cell-tropic human immunodeficiency virus type 1.
Journal of virology 1997;71(12):9664-71.
1997: MJ Endres; Salman Jaffer; Beth Haggarty; JD Turner; Benjamin J Doranz; P J O'Brien; Dennis L Kolson; James A Hoxie
Targeting of HIV- and SIV-infected cells by CD4-chemokine receptor pseudotypes.
Science (New York, N.Y.) 1997;278(5342):1462-4.
1997: Nathalie Signoret; J Oldridge; Annegret Pelchen-Matthews; PJ Klasse; T Tran; Lawrence F Brass; MM Rosenkilde; Thue W Schwartz; W Holmes; Walter S Dallas; M A Luther; Timothy Wells; James A Hoxie; Mark Marsh
Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.
The Journal of cell biology 1997;139(3):651-64.
1997: R Bron; PJ Klasse; D Wilkinson; Paul R Clapham; Annegret Pelchen-Matthews; C Power; Timothy Wells; J Kim; Stephen Peiper; James A Hoxie; Mark Marsh
Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.
Journal of virology 1997;71(11):8405-15.
1997: Ehud Lavi; JM Strizki; AM Ulrich; Wei Zhang; Li Fu; Q Wang; M O'Connor; James A Hoxie; Francisco González-Scarano
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.
The American journal of pathology 1997;151(4):1035-42.
1997: S Ugolini; Maxime Moulard; I Mondor; N Barois; D Demandolx; James A Hoxie; Anne Brelot; Marc Alizon; Jean Davoust; Quentin J Sattentau
HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):3000-8.
1997: R Ramachandran; A S Klufas; M Molino; M Ahuja; James A Hoxie; Lawrence F Brass
Release of the thrombin receptor (PAR-1) N-terminus from the surface of human platelets activated by thrombin.
Thrombosis and haemostasis 1997;78(3):1119-24.
1997: JM Strizki; JD Turner; Ronald G Collman; James A Hoxie; Francisco González-Scarano
A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB).
Journal of virology 1997;71(7):5678-83.
1997: Z Lu; Joanne F Berson; Y Chen; JD Turner; T Zhang; Matthew Sharron; M H Jenks; Zixuan Wang; J Kim; J Rucker; James A Hoxie; Stephen Peiper; Robert W Doms
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):6426-31.
1997: Laurent Picard; D A Wilkinson; Aine McKnight; Patrick W Gray; James A Hoxie; Paul R Clapham; Robin A Weiss
Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry.
Virology 1997;231(1):105-11.
1997: M Molino; D F Bainton; James A Hoxie; Shaun R Coughlin; Lawrence F Brass
Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation.
The Journal of biological chemistry 1997;272(9):6011-7.
1997: M Molino; Elliot S Barnathan; R Numerof; J Clark; M Dreyer; A Cumashi; James A Hoxie; Norman M Schechter; Marilyn J Woolkalis; Lawrence F Brass
Interactions of mast cell tryptase with thrombin receptors and PAR-2.
The Journal of biological chemistry 1997;272(7):4043-9.
1997: Brian J Willett; Margaret J Hosie; James C Neil; JD Turner; James A Hoxie
Common mechanism of infection by lentiviruses.
Nature 1997;385(6617):587.
1997: Joseph Hesselgesser; Meredith Halks-Miller; V DelVecchio; Stephen Peiper; James A Hoxie; Dennis L Kolson; D Taub; Richard Horuk
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.
Current biology : CB 1997;7(2):112-21.
1997: Aine McKnight; D Wilkinson; Graham Simmons; Simon J Talbot; Laurent Picard; M Ahuja; Mark Marsh; James A Hoxie; Paul R Clapham
Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
Journal of virology 1997;71(2):1692-6.
1996: M J Endres; Paul R Clapham; Mark Marsh; M Ahuja; JD Turner; Aine McKnight; J F Thomas; B Stoebenau-Haggarty; S Choe; P J Vance; Timothy Wells; Christine A Power; S S Sutterwala; Robert W Doms; Nathaniel R Landau; James A Hoxie
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
Cell 1996;87(4):745-56.
1996: Joseph Cotropia; Kenneth Ugen; S Kliks; Kristina Broliden; P A Broliden; James A Hoxie; V Srikantan; William V Williams; David B Weiner
A human monoclonal antibody to HIV-1 gp41 with neutralizing activity against diverse laboratory isolates.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;12(3):221-32.
1996: M M Sauter; Annegret Pelchen-Matthews; R Bron; Mark Marsh; Celia C LaBranche; P J Vance; J Romano; B S Haggarty; Timothy K Hart; W M Lee; James A Hoxie
An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface.
The Journal of cell biology 1996;132(5):795-811.
1996: T M Richardson; B L Stryjewski; Christopher C Broder; James A Hoxie; J R Mascola; Patricia L Earl; Robert W Doms
Humoral response to oligomeric human immunodeficiency virus type 1 envelope protein.
Journal of virology 1996;70(2):753-62.
1995: Celia C LaBranche; M M Sauter; B S Haggarty; P J Vance; J Romano; Timothy K Hart; Peter J Bugelski; Mark Marsh; James A Hoxie
A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells.
Journal of virology 1995;69(9):5217-27.
1995: Lawrence F Brass; Marilyn J Woolkalis; James A Hoxie
Trafficking thrombin receptors Biodiversity on the receptor superhighway.
Trends in cardiovascular medicine 1995;5(4):123-8.
1995: M Molino; N Blanchard; E Belmonte; A P Tarver; Charles S Abrams; James A Hoxie; Chiara Cerletti; Lawrence F Brass
Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G.
The Journal of biological chemistry 1995;270(19):11168-75.
1995: M J Woolkalis; T M DeMelfi; N Blanchard; James A Hoxie; Lawrence F Brass
Regulation of thrombin receptors on human umbilical vein endothelial cells.
The Journal of biological chemistry 1995;270(17):9868-75.
1994: Celia C LaBranche; M M Sauter; B S Haggarty; P J Vance; J Romano; Timothy K Hart; Peter J Bugelski; James A Hoxie
Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.
Journal of virology 1994;68(11):7665-7.
1994: Celia C LaBranche; M M Sauter; B S Haggarty; P J Vance; J Romano; Timothy K Hart; Peter J Bugelski; James A Hoxie
Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.
Journal of virology 1994;68(9):5509-22.
1994: Lawrence F Brass; M Ahuja; E Belmonte; N Blanchard; S Pizarro; A Tarver; James A Hoxie
Thrombin receptors: turning them off after turning them on.
Seminars in hematology 1994;31(3):251-60.
1994: Lawrence F Brass; M Ahuja; E Belmonte; S Pizarro; A Tarver; James A Hoxie
The human platelet thrombin receptor. Turning it on and turning it off.
Annals of the New York Academy of Sciences 1994;714():1-12.
1994: Lawrence F Brass; S Pizarro; M Ahuja; E Belmonte; N Blanchard; J M Stadel; James A Hoxie
Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling.
The Journal of biological chemistry 1994;269(4):2943-52.
1993: Lawrence F Brass; James A Hoxie; David R Manning
Signaling through G proteins and G protein-coupled receptors during platelet activation.
Thrombosis and haemostasis 1993;70(1):217-23.
1993: James A Hoxie; M Ahuja; E Belmonte; S Pizarro; Robert Parton; Lawrence F Brass
Internalization and recycling of activated thrombin receptors.
The Journal of biological chemistry 1993;268(18):13756-63.
1993: Lawrence F Brass; James A Hoxie; Thomas Kieber-Emmons; David R Manning; Mortimer Poncz; M Woolkalis
Agonist receptors and G proteins as mediators of platelet activation.
Advances in experimental medicine and biology 1993;344():17-36.
1992: Lawrence F Brass; R R Vassallo; E Belmonte; M Ahuja; Karen Cichowski; James A Hoxie
Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus.
The Journal of biological chemistry 1992;267(20):13795-8.
1992: M M Huang; Zena K Indik; Lawrence F Brass; James A Hoxie; Alan D Schreiber; Joan S Brugge
Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII.
The Journal of biological chemistry 1992;267(8):5467-73.
1992: Glen N Gaulton; Lawrence F Brass; Danuta Kozbor; C Hank Pletcher; James A Hoxie
Inhibition of T cell antigen receptor-dependent phosphorylation of CD4 in human immunodeficiency virus type 1 infected cells.
The Journal of biological chemistry 1992;267(6):4102-9.
1992: Charles S Abrams; Z M Ruggeri; Rebecca Taub; James A Hoxie; Chandrasekaran Nagaswami; John W Weisel; Sanford J Shattil
Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen.
The Journal of biological chemistry 1992;267(4):2775-85.
1991: James A Hoxie; Lawrence F Brass; C Hank Pletcher; B S Haggarty; Beatrice H Hahn
Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4.
Journal of virology 1991;65(9):5096-101.
1991: James A Hoxie
Hypothetical assignment of intrachain disulfide bonds for HIV-2 and SIV envelope glycoproteins.
AIDS research and human retroviruses 1991;7(6):495-9.
1991: James A Hoxie
CD4 envelope interactions of HIV-1 and related human retroviruses.
Advances in experimental medicine and biology 1991;300():159-66.
1990: P Kumar; H X Hui; John C Kappes; B S Haggarty; James A Hoxie; S K Arya; George M Shaw; Beatrice H Hahn
Molecular characterization of an attenuated human immunodeficiency virus type 2 isolate.
Journal of virology 1990;64(2):890-901.
1989: J M Harouse; Charles Kunsch; H T Hartle; M A Laughlin; James A Hoxie; Brian Wigdahl; F Gonzalez-Scarano
CD4-independent infection of human neural cells by human immunodeficiency virus type 1.
Journal of virology 1989;63(6):2527-33.
1988: James A Hoxie; B S Haggarty; S E Bonser; J L Rackowski; Hua Shan; P J Kanki
Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection.
Journal of virology 1988;62(8):2557-68.
1988: L I Kong; S W Lee; John C Kappes; J S Parkin; D Decker; James A Hoxie; Beatrice H Hahn; George M Shaw
West African HIV-2-related human retrovirus with attenuated cytopathicity.
Science (New York, N.Y.) 1988;240(4858):1525-9.
1988: James A Hoxie; J L Rackowski; B S Haggarty; Glen N Gaulton
T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(3):786-95.
1987: James A Hoxie; Timothy P. Fitzharris; P R Youngbar; D M Matthews; J L Rackowski; S F Radka
Nonrandom association of cellular antigens with HTLV-III virions.
Human immunology 1987;18(1):39-52.
1987: F Gonzalez-Scarano; M N Waxham; A M Ross; James A Hoxie
Sequence similarities between human immunodeficiency virus gp41 and paramyxovirus fusion proteins.
AIDS research and human retroviruses 1987;3(3):245-52.
1986: James A Hoxie; J D Alpers; J L Rackowski; K Huebner; B S Haggarty; A J Cedarbaum; J C Reed
Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV.
Science (New York, N.Y.) 1986;234(4780):1123-7.
1986: James A Hoxie; J L Rackowski; A J Cedarbaum; S Hurwitz; P M Catalano
Relation of human T lymphotropic virus type III antibodies to T lymphocyte subset abnormalities in hemophiliac patients.
The American journal of medicine 1986;81(2):201-7.
1986: James A Hoxie; Lawrence E Flaherty; B S Haggarty; J L Rackowski
Infection of T4 lymphocytes by HTLV-III does not require expression of the OKT4 epitope.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(2):361-3.
1985: James A Hoxie; B S Haggarty; J L Rackowski; N Pillsbury; J A Levy
Persistent noncytopathic infection of normal human T lymphocytes with AIDS-associated retrovirus.
Science (New York, N.Y.) 1985;229(4720):1400-2.