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Marc Hoylaerts

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Bianca Hemmeryckx; Uwe Himmelreich; Marc F Hoylaerts; Jan D'Hooge; David J Gallacher; Hua Rong Lu; Melissa Swinnen; Henri R Lijnen
Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?
Tina Kiffer-Moreira; Vicky E Macrae; Nicholas D Cosford; Russell Dahl; Colin Farquharson; Marc F Hoylaerts; Sonoko Narisawa; Campbell Sheen; Boguslaw Stec; Manisha C Yadav; Dongxing Zhu; José Luis Millán
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.
Jan Emmerechts; Steven Haenen; Bianca Hemmeryckx; Peter H Hoet; Serena Loyen; Ben Nemery; Soetkin Van Kerckhoven; Jeroen A J Vanoirbeek; Vanessa De Vooght; Marc F Hoylaerts
Thrombogenic changes in young and old mice upon subchronic exposure to air pollution in an urban roadside tunnel.

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2013: Bianca Hemmeryckx; Uwe Himmelreich; Marc F Hoylaerts; Jan D'Hooge; David J Gallacher; Hua Rong Lu; Melissa Swinnen; Henri R Lijnen
Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?
European journal of pharmacology 2013;700(1-3):23-31.
2013: Tina Kiffer-Moreira; Vicky E Macrae; Nicholas D Cosford; Russell Dahl; Colin Farquharson; Marc F Hoylaerts; Sonoko Narisawa; Campbell Sheen; Boguslaw Stec; Manisha C Yadav; Dongxing Zhu; José Luis Millán
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):81-91.
2012: Jan Emmerechts; Steven Haenen; Bianca Hemmeryckx; Peter H Hoet; Serena Loyen; Ben Nemery; Soetkin Van Kerckhoven; Jeroen A J Vanoirbeek; Vanessa De Vooght; Marc F Hoylaerts
Thrombogenic changes in young and old mice upon subchronic exposure to air pollution in an urban roadside tunnel.
Thrombosis and haemostasis 2012;108(4):756-68.
2012: Thomas Vanassche; Jan Verhaegen; Marc F Hoylaerts; Alexandre Kauskot; Willy E Peetermans; Olaf Schneewind; Joanne van Ryn; Peter Verhamme
Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation.
Thrombosis and haemostasis 2012;107(6):1107-21.
2012: Alexandre Kauskot; Serena Loyen; Peter Verhamme; Michela Di Michele; Kathleen Freson; Marc F Hoylaerts
A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1.
Blood 2012;119(17):4056-65.
2012: Bianca Hemmeryckx; Marc F Hoylaerts; Edwin G Bovill; Jan Emmerechts; H Roger Lijnen
Effect of ageing on the murine venous circulation.
Histochemistry and cell biology 2012;137(4):537-46.
2012: J Emmerechts; Marc F Hoylaerts; Marc Jacquemin; Alexandre Kauskot; C Long; S Loyen; I Van Linthout; T Vanassche; K Cludts; Peter Verhamme
Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis.
Thrombosis research 2012;129(4):514-9.
2012: Bianca Hemmeryckx; Marc F Hoylaerts; H Roger Lijnen
Effect of premature aging on murine adipose tissue.
Experimental gerontology 2012;47(3):256-62.
2012: Alexandre Kauskot; Marc F Hoylaerts
Platelet receptors.
Handbook of experimental pharmacology 2012;(210):23-57.
2012: J Emmerechts; F Fierens; L Jacobs; S Loyen; C Mathieu; T S Nawrot; B Nemery; Soetkin Van Kerckhoven; Marc F Hoylaerts
Air pollution-associated procoagulant changes: the role of circulating microvesicles.
Journal of thrombosis and haemostasis : JTH 2012;10(1):96-106.
2011: Bianca Hemmeryckx; Hidde Bult; Jan Emmerechts; Paul Fransen; Alexandre Kauskot; H Roger Lijnen; Cor E Van Hove; Marc F Hoylaerts
Progression of the prothrombotic state in aging Bmal1-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(11):2552-9.
2011: Ellen Vercauteren; Jan Emmerechts; Miet Peeters; Marc F Hoylaerts; Paul J Declerck; Ann Gils
Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model.
Blood 2011;117(17):4615-22.
2011: Katrien M J Devreese; Kathelijne Peerlinck; Marc F Hoylaerts
Diagnostic test combinations associated with thrombosis in lupus anticoagulant positive patients.
Thrombosis and haemostasis 2011;105(4):736-8.
2011: Bianca Hemmeryckx; Uwe Himmelreich; Marc F Hoylaerts; Henri R Lijnen
Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice.
Obesity (Silver Spring, Md.) 2011;19(3):659-61.
2011: J Emmerechts; Marc F Hoylaerts
The influence of air pollution on health: mechanistic implications.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2011;73(5-6):339-51.
2011: Karl-Erik Eilertsen; Hanne K Mæhre; Katrien Cludts; Jan O Olsen; Marc F Hoylaerts
Dietary enrichment of apolipoprotein E-deficient mice with extra virgin olive oil in combination with seal oil inhibits atherogenesis.
Lipids in health and disease 2011;10():41.
2011: Lotte Jacobs; Jan Emmerechts; Marc F Hoylaerts; Chantal Mathieu; Peter H M Hoet; Benoit Nemery; Tim Nawrot
Traffic air pollution and oxidized LDL.
PloS one 2011;6(1):e16200.
2010: J Emmerechts; Ernesto Alfaro-Moreno; B M Vanaudenaerde; B Nemery; Marc F Hoylaerts
Short-term exposure to particulate matter induces arterial but not venous thrombosis in healthy mice.
Journal of thrombosis and haemostasis : JTH 2010;8(12):2651-61.
2010: Katrien M J Devreese; Marc F Hoylaerts
Is there an association between complement activation and antiphospholipid antibody-related thrombosis?
Thrombosis and haemostasis 2010;104(6):1279-81.
2010: Thomas Vanassche; Jan Verhaegen; Willy E Peetermans; Marc F Hoylaerts; Peter Verhamme
Dabigatran inhibits Staphylococcus aureus coagulase activity.
Journal of clinical microbiology 2010;48(11):4248-50.
2010: Marc F Hoylaerts
To the heart of the APS puzzle.
Blood 2010;116(16):2867-9.
2010: Karen Peeters; Serena Loyen; Soetkin Van Kerckhoven; Katinka Stoffels; Marc F Hoylaerts; Chris Van Geet; Kathleen Freson
Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis.
British journal of haematology 2010;151(1):54-61.
2010: Judith M E M Cosemans; Roger van Kruchten; S Olieslagers; Leon J Schurgers; F K Verheyen; Imke C A Munnix; J Waltenberger; A Angelillo-Scherrer; Marc F Hoylaerts; P Carmeliet; Johan W M Heemskerk
Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization.
Journal of thrombosis and haemostasis : JTH 2010;8(8):1797-808.
2010: Katrien M J Devreese; Marc F Hoylaerts
Challenges in the diagnosis of the antiphospholipid syndrome.
Clinical chemistry 2010;56(6):930-40.
2010: Frédéric Adam; Alexandre Kauskot; Paquita Nurden; Eric Sulpice; Marc F Hoylaerts; Roger J Davis; Jean-Philippe Rosa; Marijke Bryckaert
Platelet JNK1 is involved in secretion and thrombus formation.
Blood 2010;115(20):4083-92.
2010: Pietro Ciancaglini; Manisha C Yadav; Ana Maria Sper Simão; Sonoko Narisawa; João Martins Pizauro; Colin Farquharson; Marc F Hoylaerts; José Luis Millán
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(4):716-23.
2010: Ana Maria S Simão; Manisha C Yadav; Sonoko Narisawa; Mayte Bolean; Joao Martins Pizauro; Marc F Hoylaerts; Pietro Ciancaglini; José Luis Millán
Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics.
The Journal of biological chemistry 2010;285(10):7598-609.
2010: Lotte Jacobs; Jan Emmerechts; Chantal Mathieu; Marc F Hoylaerts; Frans Fierens; Peter H Hoet; Benoit Nemery; Tim S Nawrot
Air pollution related prothrombotic changes in persons with diabetes.
Environmental health perspectives 2010;118(2):191-6.
2010: P Witters; Marc F Hoylaerts; Kathleen Freson; R de Vos; J van Pelt; F Nevens; C van Geet; David Cassiman
ADP-degrading enzymes inhibit platelet activation in bile duct-ligated rats.
Journal of thrombosis and haemostasis : JTH 2010;8(2):360-8.
2010: Katrien M J Devreese; Kathelijne Peerlinck; Marc F Hoylaerts
Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants.
Blood 2010;115(4):870-8.
2010: H Roger Lijnen; Kathleen Freson; Marc F Hoylaerts
Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity.
Journal of obesity 2010;2010():.
2010: Bianca Hemmeryckx; Dirk Loeckx; Tom Dresselaers; Uwe Himmelreich; Marc F Hoylaerts; H Roger Lijnen
Age-associated adaptations in murine adipose tissues.
Endocrine journal 2010;57(10):925-30.
2010: Hu Hu; Marc F Hoylaerts
The P2X1 ion channel in platelet function.
Platelets 2010;21(3):153-66.
2009: Audrey C A Cleuren; Berthe Van Hoef; Marc F Hoylaerts; Bart J M van Vlijmen; H Roger Lijnen
Short-term ethinyl estradiol treatment suppresses inferior caval vein thrombosis in obese mice.
Thrombosis and haemostasis 2009;102(5):993-1000.
2009: Björn K I Meijers; Soetkin Van Kerckhoven; Kristin Verbeke; Wim Dehaen; Yves Vanrenterghem; Marc F Hoylaerts; Pieter Evenepoel
The uremic retention solute p-cresyl sulfate and markers of endothelial damage.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2009;54(5):891-901.
2009: Chris I Jones; Sarah Bray; Stephen F Garner; Jonathan Stephens; Bernard de Bono; Will G J Angenent; David Bentley; Philippa Burns; Alison Coffey; Panos Deloukas; Mark Earthrowl; Richard W Farndale; Marc F Hoylaerts; Kerstin Koch; Angela Rankin; Catherine M Rice; Jane Rogers; Nilesh J Samani; Michael Steward; Adam Walker; Nicholas A Watkins; Jan-Willem Akkerman; Frank Dudbridge; Alison H Goodall; Willem H Ouwehand
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Blood 2009;114(7):1405-16.
2009: Katrien M J Devreese; Marc F Hoylaerts
Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome.
European journal of haematology 2009;83(1):1-16.
2009: H Roger Lijnen; S Helsen; Marc F Hoylaerts
Antithrombotic effect of clopidogrel in a vena cava thrombosis model in obese mice.
Thrombosis research 2009;123(5):763-4.
2009: Peter Verhamme; Marc F Hoylaerts
Hemostasis and inflammation: two of a kind?
Thrombosis journal 2009;7():15.
2009: Katrien Devreese; Kathelijne Peerlinck; Jef Arnout; Marc F Hoylaerts
Laboratory detection of the antiphospholipid syndrome via calibrated automated thrombography.
Thrombosis and haemostasis 2009;101(1):185-96.
2008: Rute Moura; Marc Tjwa; Petra Vandervoort; Soetkin Van Kerckhoven; Paul Holvoet; Marc F Hoylaerts
Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.
Circulation research 2008;103(10):1181-9.
2008: Ernesto Alfaro-Moreno; Tim Nawrot; Bart M Vanaudenaerde; Marc F Hoylaerts; Jeroen A J Vanoirbeek; Benoit Nemery; Peter H M Hoet
Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(5):1184-94.
2008: Arnaud Bonnefoy; Marc F Hoylaerts
Thrombospondin-1 in von Willebrand factor function.
Current drug targets 2008;9(10):822-32.
2008: Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stephane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean-Marc Herbert; Mark Waer; Pablo García de Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F Hoylaerts; Lieve Moons
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Blood 2008;111(8):4096-105.
2008: Kathleen Freson; Karen Peeters; Rita De Vos; Christine Wittevrongel; Chantal Thys; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.
Blood 2008;111(4):1885-93.
2008: Veerle Labarque; Kathleen Freson; Chantal Thys; Christine Wittevrongel; Marc F Hoylaerts; Rita De Vos; Nathalie Goemans; Chris Van Geet
Increased Gs signalling in platelets and impaired collagen activation, due to a defect in the dystrophin gene, result in increased blood loss during spinal surgery.
Human molecular genetics 2008;17(3):357-66.
2008: Nobuo Nagai; Marc F Hoylaerts; David Gallacher; Hua Rong Lu; H Roger Lijnen
Prothrombotic effect of Rofecoxib in a murine venous thrombosis model.
Thrombosis research 2008;122(5):668-73.
2008: Alexandre Kauskot; Márcia R Cominetti; O H P Ramos; Iga Bechyne; Jean-Marie Renard; Marc F Hoylaerts; Michel Crepin; Chantal Legrand; Heloisa S Selistre-de-Araujo; Arnaud Bonnefoy
Hemostatic effects of recombinant DisBa-01, a disintegrin from Bothrops alternatus.
Frontiers in bioscience : a journal and virtual library 2008;13():6604-16.
2008: Nobuo Nagai; Marc F Hoylaerts; Audrey C A Cleuren; Bart J M van Vlijmen; H Roger Lijnen
Obesity promotes injury induced femoral artery thrombosis in mice.
Thrombosis research 2008;122(4):549-55.
2007: Alexandre Kauskot; Frédéric Adam; Alexandra Mazharian; Nadine Ajzenberg; Eliane Berrou; Arnaud Bonnefoy; Jean-Philippe Rosa; Marc F Hoylaerts; Marijke Bryckaert
Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation.
The Journal of biological chemistry 2007;282(44):31990-9.
2007: Sonoko Narisawa; Marc F Hoylaerts; Kutbuddin S Doctor; Michiko N Fukuda; David H Alpers; José Luis Millán
A novel phosphatase upregulated in Akp3 knockout mice.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G1068-77.
2007: Sonoko Narisawa; Dympna Harmey; Manisha C Yadav; W Charles O'Neill; Marc F Hoylaerts; José Luis Millán
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(11):1700-10.
2007: Nobuo Nagai; H Roger Lijnen; Audrey C A Cleuren; Frits R Rosendaal; Berthe Van Hoef; Marc F Hoylaerts; Bart J M van Vlijmen
Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice.
Thrombosis and haemostasis 2007;98(4):858-63.
2007: Rute Moura; Marc Tjwa; Petra Vandervoort; Katrien Cludts; Marc F Hoylaerts
Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(10):2163-9.
2007: Katrien M J Devreese; Walter Wijns; Isabelle Combes; Soetkin Van Kerckhoven; Marc F Hoylaerts
Thrombin generation in plasma of healthy adults and children: chromogenic versus fluorogenic thrombogram analysis.
Thrombosis and haemostasis 2007;98(3):600-13.
2007: Abderrahim Nemmar; Peter H M Hoet; Petra Vandervoort; David Dinsdale; Benoit Nemery; Marc F Hoylaerts
Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet-leukocyte activation: role of P-selectin.
Journal of thrombosis and haemostasis : JTH 2007;5(6):1217-26.
2007: Ihsan Bakir; Marc F Hoylaerts; Tom Kink; Luc Foubert; Peter Luyten; Soetkin Van Kerckhoven; Veerle Leunens; Hilde Bollen; Helmut Reul; Bart Meyns
Mechanical stress activates platelets at a subhemolysis level: an in vitro study.
Artificial organs 2007;31(4):316-23.
2007: Jos Vermylen; Marc F Hoylaerts
The procoagulant effects of air pollution.
Journal of thrombosis and haemostasis : JTH 2007;5(2):250-1.
2007: Sabrina Kellouche; SAMIA MOURAH; Arnaud Bonnefoy; Damien Schoëvaert; Marie-Pierre Podgorniak; Fabien Calvo; Marc F Hoylaerts; Chantal Legrand; Christine Dosquet
Platelets, thrombospondin-1 and human dermal fibroblasts cooperate for stimulation of endothelial cell tubulogenesis through VEGF and PAI-1 regulation.
Experimental cell research 2007;313(3):486-99.
2007: Gerlinde Van de Walle; Anne Schoolmeester; Brecht F Iserbyt; Judith M E M Cosemans; Johan W M Heemskerk; Marc F Hoylaerts; Alan Nurden; Karen Vanhoorelbeke; Hans Deckmyn
Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets.
Blood 2007;109(2):595-602.
2006: Arnaud Bonnefoy; R A Romijn; Petra Vandervoort; I VAN Rompaey; Jos Vermylen; Marc F Hoylaerts
von Willebrand factor A1 domain can adequately substitute for A3 domain in recruitment of flowing platelets to collagen.
Journal of thrombosis and haemostasis : JTH 2006;4(10):2151-61.
2006: Dympna Harmey; Kristen A Johnson; Jonathan Zelken; Nancy P Camacho; Marc F Hoylaerts; Masaki Noda; Robert Terkeltaub; José Luis Millán
Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(9):1377-86.
2006: Marc F Hoylaerts; Lan Ding; Sonoko Narisawa; Soetkin Van Kerckhoven; José Luis Millan
Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.
Biochemistry 2006;45(32):9756-66.
2006: Sandra Cauwenberghs; Marion A H Feijge; Geja Hageman; Marc F Hoylaerts; Jan-Willem N Akkerman; Joyce Curvers; Johan W M Heemskerk
Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.
Transfusion 2006;46(6):1018-28.
2006: Cécile Oury; Kim Daenens; H Hu; Emese Toth-Zsamboki; M Bryckaert; Marc F Hoylaerts
ERK2 activation in arteriolar and venular murine thrombosis: platelet receptor GPIb vs. P2X.
Journal of thrombosis and haemostasis : JTH 2006;4(2):443-52.
2006: Arnaud Bonnefoy; Kim Daenens; Hendrik Feys; Rita De Vos; Petra Vandervoort; Jos Vermylen; Jack Lawler; Marc F Hoylaerts
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.
Blood 2006;107(3):955-64.
2006: Abderrahim Nemmar; Marc F Hoylaerts; Benoit Nemery
Effects of particulate air pollution on hemostasis.
Clinics in occupational and environmental medicine 2006;5(4):865-81.
2006: Jef Arnout; Marc F Hoylaerts; H Roger Lijnen
Haemostasis.
Handbook of experimental pharmacology 2006;(176 Pt 2):1-41.
2006: Cécile Oury; Emese Toth-Zsamboki; Jos Vermylen; Marc F Hoylaerts
The platelet ATP and ADP receptors.
Current pharmaceutical design 2006;12(7):859-75.
2005: Jos Vermylen; Abderrahim Nemmar; Benoit Nemery; Marc F Hoylaerts
Ambient air pollution and acute myocardial infarction.
Journal of thrombosis and haemostasis : JTH 2005;3(9):1955-61.
2005: Els Melis; Lieve Moons; Jef Arnout; Marc F Hoylaerts; Désiré Collen; Peter Carmeliet; Mieke Dewerchin
Thrombophilia in mice expressing a tissue factor variant lacking its transmembrane and cytosolic domain.
Biochemical and biophysical research communications 2005;333(2):488-95.
2005: Alexandra Mazharian; Séverine Roger; Pascal Maurice; Eliane Berrou; Michel R Popoff; Marc F Hoylaerts; Françoise Fauvel-Lafeve; Arnaud Bonnefoy; Marijke Bryckaert
Differential Involvement of ERK2 and p38 in platelet adhesion to collagen.
The Journal of biological chemistry 2005;280(28):26002-10.
2005: Steven Laga; Hilde Bollen; Jef Arnout; Marc F Hoylaerts; Bart Meyns
Heparin influences human platelet behavior in cardiac surgery with or without cardiopulmonary bypass.
Artificial organs 2005;29(7):541-6.
2005: Désiré Collen; Marc F Hoylaerts
Relationship between inflammation and venous thromboembolism as studied by microparticle assessment in plasma.
Journal of the American College of Cardiology 2005;45(9):1472-3.
2005: Abderrahim Nemmar; Benoit Nemery; Peter H M Hoet; Nico van Rooijen; Marc F Hoylaerts
Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk.
American journal of respiratory and critical care medicine 2005;171(8):872-9.
2005: Anne Angelillo-Scherrer; Laurent Burnier; Nathalie Flores; Pierre Savi; Maria DeMol; Paul Schaeffer; Jean-Marc Herbert; Greg Lemke; Stephen P Goff; Glenn K Matsushima; Henry Earp; Christian Vesin; Marc F Hoylaerts; Stephane Plaisance; Désiré Collen; Edward M Conway; Bernhard Wehrle-Haller; Peter Carmeliet
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
The Journal of clinical investigation 2005;115(2):237-46.
2005: Chantal C M Appeldoorn; Arnaud Bonnefoy; Bianca C H Lutters; Kim Daenens; Theo Van berkel; Marc F Hoylaerts; Erik A L Biessen
Gallic acid antagonizes P-selectin-mediated platelet-leukocyte interactions: implications for the French paradox.
Circulation 2005;111(1):106-12.
2005: Karen Vanhoorelbeke; Inge Pareyn; Agota Schlammadinger; Stephan Vauterin; Marc F Hoylaerts; Jef Arnout; Hans Deckmyn
Plasma glycocalicin as a source of GPIbalpha in the von Willebrand factor ristocetin cofactor ELISA.
Thrombosis and haemostasis 2005;93(1):165-71.
2004: Alexey Kozlenkov; Marie Helene Le Du; Philippe Cuniasse; Tor Ny; Marc F Hoylaerts; José Luis Millán
Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(11):1862-72.
2004: Abderrahim Nemmar; Peter H M Hoet; Jos Vermylen; Benoit Nemery; Marc F Hoylaerts
Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters.
Circulation 2004;110(12):1670-7.
2004: Marijke J E Kuijpers; Valerie Schulte; Cécile Oury; Theo Lindhout; Jos L V Broers; Marc F Hoylaerts; Bernhard Nieswandt; Johan W M Heemskerk
Facilitating roles of murine platelet glycoprotein Ib and alphaIIbbeta3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation.
The Journal of physiology 2004;558(Pt 2):403-15.
2004: Anne Schoolmeester; Karen Vanhoorelbeke; Shinya Katsutani; Hilde Depraetere; Hendrik Feys; Johan M W Heemskerk; Marc F Hoylaerts; Hans Deckmyn
Monoclonal antibody IAC-1 is specific for activated alpha2beta1 and binds to amino acids 199 to 201 of the integrin alpha2 I-domain.
Blood 2004;104(2):390-6.
2004: Cécile Oury; Elsie Sticker; Heidi Cornelissen; Rita De Vos; Jos Vermylen; Marc F Hoylaerts
ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation.
The Journal of biological chemistry 2004;279(25):26266-73.
2004: Els Melis; Arnaud Bonnefoy; Kim Daenens; H Yamamoto; Jos Vermylen; Marc F Hoylaerts
alphaIIbbeta3 antagonism vs. antiadhesive treatment to prevent platelet interactions with vascular subendothelium.
Journal of thrombosis and haemostasis : JTH 2004;2(6):993-1002.
2004: Abderrahim Nemmar; Marc F Hoylaerts; Peter H M Hoet; Benoit Nemery
Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects.
Toxicology letters 2004;149(1-3):243-53.
2004: Kathleen Freson; Hitoshi Hashimoto; Chantal Thys; Christine Wittevrongel; Sophie Danloy; Yoshiko Morita; Norihito Shintani; Yoshiaki Tomiyama; Jos Vermylen; Marc F Hoylaerts; Akemichi Baba; Chris Van Geet
The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation.
The Journal of clinical investigation 2004;113(6):905-12.
2003: Abderrahim Nemmar; Benoit Nemery; Peter H M Hoet; Jos Vermylen; Marc F Hoylaerts
Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters: role of histamine.
American journal of respiratory and critical care medicine 2003;168(11):1366-72.
2003: Emese Toth-Zsamboki; Cécile Oury; Heidi Cornelissen; Rita De Vos; Jos Vermylen; Marc F Hoylaerts
P2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.
The Journal of biological chemistry 2003;278(47):46661-7.
2003: Arnaud Bonnefoy; Jos Vermylen; Marc F Hoylaerts
Inhibition of von Willebrand factor-GPIb/IX/V interactions as a strategy to prevent arterial thrombosis.
Expert review of cardiovascular therapy 2003;1(2):257-69.
2003: Marc F Hoylaerts
Do lipid rafts contribute to platelet activation?
Journal of thrombosis and haemostasis : JTH 2003;1(6):1140-1.
2003: Kathleen Freson; Jaak Jaeken; Monique Van Helvoirt; Francis de Zegher; Christine Wittevrongel; Chantal Thys; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation.
Human molecular genetics 2003;12(10):1121-30.
2003: Cécile Oury; Marijke J E Kuijpers; Emese Toth-Zsamboki; Arnaud Bonnefoy; Sophie Danloy; Ingrid Vreys; Marion A H Feijge; Rita De Vos; Jos Vermylen; Johan W M Heemskerk; Marc F Hoylaerts
Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype.
Blood 2003;101(10):3969-76.
2003: Ting Zhu; HuCheng Zhao; Jia Wu; Marc F Hoylaerts
Three-dimensional reconstruction of thrombus formation during photochemically induced arterial and venous thrombosis.
Annals of biomedical engineering 2003;31(5):515-25.
2003: Chantal C M Appeldoorn; Tom J M Molenaar; Arnaud Bonnefoy; Steven H van Leeuwen; Petra Vandervoort; Marc F Hoylaerts; Theo Van berkel; Erik A L Biessen
Rational optimization of a short human P-selectin-binding peptide leads to nanomolar affinity antagonists.
The Journal of biological chemistry 2003;278(12):10201-7.
2003: Abderrahim Nemmar; Peter H M Hoet; David Dinsdale; Jos Vermylen; Marc F Hoylaerts; Benoit Nemery
Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis.
Circulation 2003;107(8):1202-8.
2003: Arnaud Bonnefoy; Hiroshi Yamamoto; Chantal Thys; Morikazu Kito; Jos Vermylen; Marc F Hoylaerts
Shielding the front-strand beta 3 of the von Willebrand factor A1 domain inhibits its binding to platelet glycoprotein Ibalpha.
Blood 2003;101(4):1375-83.
2003: Abderrahim Nemmar; Marc F Hoylaerts; Peter H M Hoet; Jozef Vermylen; Benoit Nemery
Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis.
Toxicology and applied pharmacology 2003;186(1):38-45.
2003: Kathleen Freson; Chantal Thys; Christine Wittewrongel; Jos Vermylen; Marc F Hoylaerts; Chris Van Geet
Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.
Human genetics 2003;112(1):42-9.
2003: Milosz Jankowski; Ingrid Vreys; Christine Wittevrongel; Doris Boon; Jos Vermylen; Marc F Hoylaerts; Jef Arnout
Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster.
Blood 2003;101(1):157-62.
2002: Tom J M Molenaar; Chantal C M Appeldoorn; Sonja A M de Haas; Ingrid N Michon; Arnaud Bonnefoy; Marc F Hoylaerts; Hans Pannekoek; Theo Van berkel; Johan Kuiper; Erik A L Biessen
Specific inhibition of P-selectin-mediated cell adhesion by phage display-derived peptide antagonists.
Blood 2002;100(10):3570-7.
2002: Kathleen Freson; Chantal Thys; Christine Wittevrongel; Willem Proesmans; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Pseudohypoparathyroidism type Ib with disturbed imprinting in the GNAS1 cluster and Gsalpha deficiency in platelets.
Human molecular genetics 2002;11(22):2741-50.
2002: Abderrahim Nemmar; Marc F Hoylaerts; Peter H M Hoet; David Dinsdale; Tim Smith; Haiyan Xu; Jos Vermylen; Benoit Nemery
Ultrafine particles affect experimental thrombosis in an in vivo hamster model.
American journal of respiratory and critical care medicine 2002;166(7):998-1004.
2002: Cécile Oury; Emese Toth-Zsamboki; Jos Vermylen; Marc F Hoylaerts
P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen.
Blood 2002;100(7):2499-505.
2002: Sonia Di Mauro; Thomas Manes; Lovisa Hessle; Alexey Kozlenkov; João M Pizauro; Marc F Hoylaerts; José Luis Millán
Kinetic characterization of hypophosphatasia mutations with physiological substrates.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(8):1383-91.
2002: Emese Toth-Zsamboki; Cécile Oury; Hiroyuki Watanabe; Bernd Nilius; Jos Vermylen; Marc F Hoylaerts
The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function.
FEBS letters 2002;524(1-3):15-9.
2002: Alexey Kozlenkov; Thomas Manes; Marc F Hoylaerts; José Luis Millán
Function assignment to conserved residues in mammalian alkaline phosphatases.
The Journal of biological chemistry 2002;277(25):22992-9.
2002: Gregor Theilmeier; Carine Michiels; Erik Spaepen; Ingrid Vreys; Désiré Collen; Jos Vermylen; Marc F Hoylaerts
Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia.
Blood 2002;99(12):4486-93.
2002: Cécile Oury; Emese Toth-Zsamboki; Jos Vermylen; Marc F Hoylaerts
Does the P(2X1del) variant lacking 17 amino acids in its extracellular domain represent a relevant functional ion channel in platelets?
Blood 2002;99(6):2275-7.
2002: Aernout Luttun; Florea Lupu; Erik Storkebaum; Marc F Hoylaerts; Lieve Moons; James Crawley; Françoise Bono; A Robin Poole; Peter Tipping; Jean-Marc Herbert; Désiré Collen; Peter Carmeliet
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(3):499-505.
2002: Charlotte Wennberg; Alexey Kozlenkov; Sonia Di Mauro; Nils Fröhlander; Lars Beckman; Marc F Hoylaerts; José Luis Millán
Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP).
Human mutation 2002;19(3):258-67.
2002: Abderrahim Nemmar; Peter H M Hoet; B Vanquickenborne; David Dinsdale; Maarten Thomeer; Marc F Hoylaerts; Hubert P Vanbilloen; Luc Mortelmans; Benoit Nemery
Passage of inhaled particles into the blood circulation in humans.
Circulation 2002;105(4):411-4.
2002: Kathleen Freson; Gert Matthijs; Chantal Thys; Paul Mariën; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation.
Human molecular genetics 2002;11(2):147-52.
2001: Marc F Hoylaerts; A Viaene; Chantal Thys; Hans Deckmyn; Jos Vermylen
Anti-vWf antibodies induce GPIbalpha and FcgammaRII mediated platelet aggregation only at low shear forces.
Journal of thrombosis and thrombolysis 2001;12(3):249-62.
2001: Emese Toth-Zsamboki; Cécile Oury; J Tytgat; Jos Vermylen; Marc F Hoylaerts
The P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel.
Thrombosis and haemostasis 2001;86(5):1338-9.
2001: Cécile Oury; Emese Toth-Zsamboki; Chantal Thys; J Tytgat; Jos Vermylen; Marc F Hoylaerts
The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
Thrombosis and haemostasis 2001;86(5):1264-71.
2001: Pieter Vermeersch; Z Nong; E Stabile; Olivier Varenne; Hilde Gillijns; Marijke Pellens; Natascha Van Pelt; Marc F Hoylaerts; I De Scheerder; Désiré Collen; Stefan Janssens
L-arginine administration reduces neointima formation after stent injury in rats by a nitric oxide-mediated mechanism.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1604-9.
2001: Kathleen Freson; Marc F Hoylaerts; Jaak Jaeken; M Eyssen; Jef Arnout; Jos Vermylen; Chris Van Geet
Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding.
Thrombosis and haemostasis 2001;86(3):733-8.
2001: Chris Van Geet; Jaak Jaeken; Kathleen Freson; T Lenaerts; Jef Arnout; Jos Vermylen; Marc F Hoylaerts
Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications.
Journal of inherited metabolic disease 2001;24(4):477-92.
2001: Thu-Hoa Ngo; Marc F Hoylaerts; I Knockaert; Els Brouwers; Paul J Declerck
Identification of a target site in plasminogen activator inhibitor-1 that allows neutralization of its inhibitor properties concomitant with an allosteric up-regulation of its antiadhesive properties.
The Journal of biological chemistry 2001;276(28):26243-8.
2001: Kathleen Freson; koenraad devriendt; Gert Matthijs; Achiel Van Hoof; Rita De Vos; Chantal Thys; K Minner; Marc F Hoylaerts; Jos Vermylen; Chris Van Geet
Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation.
Blood 2001;98(1):85-92.
2001: T Kawasaki; Mieke Dewerchin; H Roger Lijnen; Ingrid Vreys; Jos Vermylen; Marc F Hoylaerts
Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development.
Circulation research 2001;88(2):159-66.
2001: Anne Angelillo-Scherrer; P de Frutos; C Aparicio; Els Melis; Pierre Savi; Florea Lupu; Jef Arnout; Mieke Dewerchin; Marc F Hoylaerts; J Herbert; Désiré Collen; B Dahlbäck; Peter Carmeliet
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.
Nature medicine 2001;7(2):215-21.
2000: B Arza; Marc F Hoylaerts; Jordi Félez; Désiré Collen; H Roger Lijnen
Prostromelysin-1 (proMMP-3) stimulates plasminogen activation by tissue-type plasminogen activator.
European journal of biochemistry / FEBS 2000;267(21):6378-84.
2000: Marc F Hoylaerts; Cécile Oury; Emese Toth-Zsamboki; Jos Vermylen
ADP receptors in platelet activation and aggregation.
Platelets 2000;11(6):307-9.
2000: Marc Jacquemin; Renaud Lavend'homme; Abdellah Benhida; Beatrijs Vanzieleghem; Roseline d'Oiron; Jean-Maurice Lavergne; H H Brackmann; R Schwaab; Thierry VandenDriessche; Marinee K L Chuah; Marc F Hoylaerts; Jean-Guy G Gilles; Kathelijne Peerlinck; Jos Vermylen; Jean-Marie Saint-Remy
A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor.
Blood 2000;96(3):958-65.
2000: Cécile Oury; Emese Toth-Zsamboki; Chris Van Geet; Chantal Thys; L Wei; Bernd Nilius; Jos Vermylen; Marc F Hoylaerts
A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.
The Journal of biological chemistry 2000;275(30):22611-4.
2000: T Kawasaki; Mieke Dewerchin; H Roger Lijnen; Jos Vermylen; Marc F Hoylaerts
Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice.
Blood 2000;96(1):153-60.
2000: Nancy Cauwenberghs; Nadine Ajzenberg; Stephan Vauterin; Marc F Hoylaerts; P J Declerck; Dominique Baruch; Hans Deckmyn
Characterization of murine anti-glycoprotein Ib monoclonal antibodies that differentiate between shear-induced and ristocetin/botrocetin-induced glycoprotein Ib-von Willebrand factor interaction.
Haemostasis 2000;30(3):139-48.
1999: Gregor Theilmeier; T Lenaerts; C Remacle; Désiré Collen; Jos Vermylen; Marc F Hoylaerts
Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress.
Blood 1999;94(8):2725-34.
1999: Jean-Guy G Gilles; Renaud Lavend'homme; Kathelijne Peerlinck; Marc Jacquemin; Marc F Hoylaerts; Sylvie Jorieux; Claudine Mazurier; Jos Vermylen; Jean-Marie Saint-Remy
Some factor VIII (FVIII) inhibitors recognise a FVIII epitope(s) that is present only on FVIII-vWF complexes.
Thrombosis and haemostasis 1999;82(1):40-5.
1999: Kathelijne Peerlinck; Marc Jacquemin; Jef Arnout; Marc F Hoylaerts; Jean-Guy G Gilles; Renaud Lavend'homme; K M Johnson; Kathleen Freson; Dorothea Scandella; Jean-Marie Saint-Remy; Jos Vermylen
Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A.
Blood 1999;93(7):2267-73.
1999: T Kawasaki; T Kaida; Jef Arnout; Jos Vermylen; Marc F Hoylaerts
A new animal model of thrombophilia confirms that high plasma factor VIII levels are thrombogenic.
Thrombosis and haemostasis 1999;81(2):306-11.
1998: Chris Van Geet; koenraad devriendt; Benedicte Eyskens; Jos Vermylen; Marc F Hoylaerts
Velocardiofacial syndrome patients with a heterozygous chromosome 22q11 deletion have giant platelets.
Pediatric research 1998;44(4):607-11.
1998: Thomas Manes; Marc F Hoylaerts; R Müller; F Lottspeich; W Hölke; José Luis Millán
Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases.
The Journal of biological chemistry 1998;273(36):23353-60.
1998: Marc Jacquemin; BG Desqueper; Abdellah Benhida; Luce Vander Elst; Marc F Hoylaerts; M Bakkus; K Thielemans; Jef Arnout; Kathelijne Peerlinck; Jean-Guy G Gilles; Jos Vermylen; Jean-Marie Saint-Remy
Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor.
Blood 1998;92(2):496-506.
1998: Marc F Hoylaerts; Chantal Thys; Jef Arnout; Jos Vermylen
Recurrent arterial thrombosis linked to autoimmune antibodies enhancing von Willebrand factor binding to platelets and inducing Fc gamma RII receptor-mediated platelet activation.
Blood 1998;91(8):2810-7.
1998: H Yamamoto; Ingrid Vreys; Jean Marie Stassen; R Yoshimoto; Jos Vermylen; Marc F Hoylaerts
Antagonism of vWF inhibits both injury induced arterial and venous thrombosis in the hamster.
Thrombosis and haemostasis 1998;79(1):202-10.
1998: Jef Arnout; Christine Wittevrongel; M Vanrusselt; Marc F Hoylaerts; Jos Vermylen
Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces.
Thrombosis and haemostasis 1998;79(1):79-86.
1997: Z Nong; Marc F Hoylaerts; Natascha Van Pelt; Désiré Collen; Stefan Janssens
Nitric oxide inhalation inhibits platelet aggregation and platelet-mediated pulmonary thrombosis in rats.
Circulation research 1997;81(5):865-9.
1997: Marc F Hoylaerts; Thomas Manes; José Luis Millán
Mammalian alkaline phosphatases are allosteric enzymes.
The Journal of biological chemistry 1997;272(36):22781-7.
1997: Jos Vermylen; Marc F Hoylaerts; Jef Arnout
Antibody-mediated thrombosis.
Thrombosis and haemostasis 1997;78(1):420-6.
1997: Marc F Hoylaerts; H Yamamoto; K Nuyts; Ingrid Vreys; Hans Deckmyn; Jos Vermylen
von Willebrand factor binds to native collagen VI primarily via its A1 domain.
The Biochemical journal 1997;324 ( Pt 1)():185-91.
1997: Marc F Hoylaerts
Platelet-vessel wall interactions in thrombosis and restenosis role of von Willebrand factor.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 1997;59(3):161-83.
1997: F Stockmans; Jean Marie Stassen; Jos Vermylen; Marc F Hoylaerts; A Nyström
A technique to investigate microvascular mural thrombus formation in arteries and veins: II. Effects of aspirin, heparin, r-hirudin, and G-4120.
Annals of plastic surgery 1997;38(1):63-8.
1997: F Stockmans; Jean Marie Stassen; Jos Vermylen; Marc F Hoylaerts; A Nyström
A technique to investigate mural thrombus formation in small arteries and veins: I. Comparative morphometric and histological analysis.
Annals of plastic surgery 1997;38(1):56-62.
1996: H Matsuno; Jean Marie Stassen; Lieve Moons; Jos Vermylen; Marc F Hoylaerts
Neointima formation in injured hamster carotid artery is effectively prevented by the combination G4120 and quinapril.
Thrombosis and haemostasis 1996;76(2):263-9.
1996: Marc F Hoylaerts; C Thys; Jean Marie Stassen; Jos Vermylen
Dose-responses to inducers and inhibitors of platelet aggregation analysed via a micro-method.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1996;7(2):187-90.
1995: H Matsuno; Jean Marie Stassen; Marc F Hoylaerts; Jos Vermylen; Hans Deckmyn
Fast and reproducible vascular neointima formation in the hamster carotid artery: effects of trapidil and captopril.
Thrombosis and haemostasis 1995;74(6):1591-6.
1995: Marc F Hoylaerts; K Nuyts; Kathelijne Peerlinck; Hans Deckmyn; Jos Vermylen
Promotion of binding of von Willebrand factor to platelet glycoprotein Ib by dimers of ristocetin.
The Biochemical journal 1995;306 ( Pt 2)():453-63.
1995: Jolan Harsfalvi; Jean Marie Stassen; Marc F Hoylaerts; E Van Houtte; R T Sawyer; Jos Vermylen; Hans Deckmyn
Calin from Hirudo medicinalis, an inhibitor of von Willebrand factor binding to collagen under static and flow conditions.
Blood 1995;85(3):705-11.
1994: S De Reys; Marc F Hoylaerts; Marc De Ley; Jos Vermylen; Hans Deckmyn
Fc-independent cross-linking of a novel platelet membrane protein by a monoclonal antibody causes platelet activation.
Blood 1994;84(2):547-55.