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Radomír Hrdina

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TOP 3
Michal Ríha; Tomáš Filipský; Radomír Hrdina; Jana Karlíčková; Kateřina Macáková; Premysl Mladenka
Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines.
Kateřina Macáková; Přemysl Mladěnka; Ilaria Proietti Silvestri; Paolo Bovicelli; Tomáš Filipský; Radomír Hrdina; Luděk Jahodář; František Trejtnar; Michal Říha; Luciano Saso
Iron reduction potentiates hydroxyl radical formation only in flavonols.
Kateřina Macáková; Premysl Mladenka; Virinder S Parmar; P Pávek; Ashok K Prasad; Tomáš Filipský; Radomír Hrdina; Luděk Jahodář; Jana Karlíčková; Zuzana Reháková; Michal Říha; Luciano Saso
In vitro platelet antiaggregatory properties of 4-methylcoumarins.

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All Publications

2013: Michal Ríha; Tomáš Filipský; Radomír Hrdina; Jana Karlíčková; Kateřina Macáková; Premysl Mladenka
Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines.
Journal of inorganic biochemistry 2013;123():80-7.
2012: Kateřina Macáková; Přemysl Mladěnka; Ilaria Proietti Silvestri; Paolo Bovicelli; Tomáš Filipský; Radomír Hrdina; Luděk Jahodář; František Trejtnar; Michal Říha; Luciano Saso
Iron reduction potentiates hydroxyl radical formation only in flavonols.
Food chemistry 2012;135(4):2584-92.
2012: Kateřina Macáková; Premysl Mladenka; Virinder S Parmar; P Pávek; Ashok K Prasad; Tomáš Filipský; Radomír Hrdina; Luděk Jahodář; Jana Karlíčková; Zuzana Reháková; Michal Říha; Luciano Saso
In vitro platelet antiaggregatory properties of 4-methylcoumarins.
Biochimie 2012;94(12):2681-6.
2012: T Filipský; Premysl Mladenka; L Zatloukalová; Radomír Hrdina
Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity.
Human & experimental toxicology 2012;31(8):830-43.
2012: Libuše Zatloukalová; Tomáš Filipský; Magdalena Holečková; Kateřina Macáková; Přemysl Mladěnka; Vladimir Palicka; Vladimír Semecký; Jaroslava Vávrová; Radomír Hrdina
Dexrazoxane provided moderate protection in a catecholamine model of severe cardiotoxicity.
Canadian journal of physiology and pharmacology 2012;90(4):473-84.
2011: Přemysl Mladěnka; Kateřina Macáková; Tomáš Filipský; Libuše Zatloukalová; Luděk Jahodář; Paolo Bovicelli; Ilaria Proietti Silvestri; Radomír Hrdina; Luciano Saso
In vitro analysis of iron chelating activity of flavonoids.
Journal of inorganic biochemistry 2011;105(5):693-701.
2010: Premysl Mladenka; Libuse Zatloukalová; Tomás Filipský; Radomír Hrdina
Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity.
Free radical biology & medicine 2010;49(6):963-75.
2010: Premysl Mladenka; Katerina Macáková; Libuse Zatloukalová; Zuzana Reháková; Brajendra K Singh; Ashok K Prasad; Virinder S Parmar; Ludek Jahodár; Radomír Hrdina; Luciano Saso
In vitro interactions of coumarins with iron.
Biochimie 2010;92(9):1108-14.
2009: Premysl Mladenka; Radomír Hrdina; Zuzana Bobrovová; Vladimir Semecky; Jirina Vávrová; Magdaléna Holecková; Vladimir Palicka; Yvona Mazurová; Petr Nachtigal
Cardiac biomarkers in a model of acute catecholamine cardiotoxicity.
Human & experimental toxicology 2009;28(10):631-40.
2009: Tomás Simůnek; Martin Stérba; Olga Popelová; Michaela Adamcová; Radomír Hrdina; Vladimír Gersl
Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron.
Pharmacological reports : PR 2009;61(1):154-71.
2009: Premysl Mladĕnka; Danuta S Kalinowski; Pavlína Haskova; Zuzana Bobrovová; Radomír Hrdina; Tomás Simůnek; Petr Nachtigal; Vladimĺr Semecký; Jaroslava Vávrová; Magdaléna Holeckova; Vladimir Palicka; Yvona Mazurová; Patric J Jansson; Des R Richardson
The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity.
Chemical research in toxicology 2009;22(1):208-17.
2006: Premysl Mladenka; Tomás Simůnek; Mojmír Hübl; Radomír Hrdina
The role of reactive oxygen and nitrogen species in cellular iron metabolism.
Free radical research 2006;40(3):263-72.
2005: Tomás Simůnek; Christa Boer; R Arthur Bouwman; Ronald Vlasblom; Amanda M G Versteilen; Martin Sterba; Vladimír Gersl; Radomír Hrdina; Prem Ponka; Jaap J de Lange; Walter J Paulus; René J P Musters
SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.
Journal of molecular and cellular cardiology 2005;39(2):345-54.
2005: Tomás Simůnek; Martin Sterba; Magdaléna Holecková; Jana Kaplanová; Ivona Klimtová; Michaela Adamcová; Vladimír Gersl; Radomír Hrdina
Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2005;18(2):163-9.
2005: T Simůnek; Ivona Klimtová; Jana Kaplanová; Martin Sterba; Yvona Mazurová; Michaela Adamcová; Radomír Hrdina; Vladimír Gersl; Prem Ponka
Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;51(3):223-31.
2005: Premysl Mladenka; Radomír Hrdina; Mojmír Hübl; Tomás Simůnek
The fate of iron in the organism and its regulatory pathways.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(3-4):127-35.
2005: Jirí Patocka; Vladimír Merka; Vratislav Hrdina; Radomír Hrdina
Pharmacological potential of endothelin receptors agonists and antagonists.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2005;48(2):67-73.
2004: Tomás Simůnek; Ivona Klimtová; Jana Kaplanová; Yvona Mazurová; Michaela Adamcová; Martin Sterba; Radomír Hrdina; Vladimír Gersl
Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents.
European journal of heart failure 2004;6(4):377-87.
2004: Jirí Patocka; Vladimír Merka; Vratislav Hrdina; Radomír Hrdina
Endothelins and sarafotoxins: peptides of similar structure and different function.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2004;47(3):157-62.
2003: Tomás Simůnek; Ivona Klimtová; Michaela Adamcová; Vladimír Gersl; Radomír Hrdina; Martin Sterba; Jana Kaplanová; Yvona Mazurová
Cardiac troponin T as an indicator of reduced left ventricular contractility in experimental anthracycline-induced cardiomyopathy.
Cancer chemotherapy and pharmacology 2003;52(5):431-4.
2003: Michaela Adamcová; V Pelouch; Vladimír Gersl; Jana Kaplanová; Yvona Mazurová; T Simůnek; Ivona Klimtová; Radomír Hrdina
Protein profiling in daunorubicin-induced cardiomyopathy.
General physiology and biophysics 2003;22(3):411-9.
2003: Michaela Adamcová; Martin Sterba; Ivona Klimtová; Tomás Simůnek; Radomír Hrdina; Vladimír Gersl; Prem Ponka
Cardiac troponins following repeated administration of an iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH)--in rabbits.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2003;46(4):171-4.
2003: Ivona Klimtová; Tomás Simůnek; Yvona Mazurová; Jana Kaplanová; Martin Sterba; Radomír Hrdina; Vladimír Gersl; Michaela Adamcová; Prem Ponka
A study of potential toxic effects after repeated 10-week administration of a new iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2003;46(4):163-70.
2002: Ivona Klimtová; Tomás Simůnek; Yvona Mazurová; Radomír Hrdina; Vladimír Gersl; Michaela Adamcová
Comparative study of chronic toxic effects of daunorubicin and doxorubicin in rabbits.
Human & experimental toxicology 2002;21(12):649-57.
2002: Radomír Hrdina; Vladimír Gersl; Ivona Klimtová; Tomás Simůnek; Yvona Mazurová; Jarmila Machácková; Michaela Adamcová
Effect of sodium 2,3-dimercaptopropane-1-sulphonate (DMPS) on chronic daunorubicin toxicity in rabbits: comparison with dexrazoxane.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2002;45(3):99-105.
2002: Michaela Adamcová; Jarmila Machácková; Vladimír Gersl; V Pelouch; T Simůnek; Ivona Klimtová; Radomír Hrdina; Prem Ponka
Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits.
Physiological research / Academia Scientiarum Bohemoslovaca 2002;51(5):443-8.
2002: Michaela Adamcová; Vladimír Gersl; Jarmila Machácková; Radomír Hrdina; Ivona Klimtová; Tomás Simůnek; Jirina Vávrová; Josef Bukac
Troponins in experimental studies.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2002;45(1):29-32.
2001: Michaela Adamcová; Jarmila Machácková; Vladimír Gersl; Radomír Hrdina; Yvona Mazurová; M Mĕlka; Milan Nobilis
[Plasma levels of troponin T in rabbits after administration of new antineoplastic agents (Oracin and Dimefluron) and daunorubicin].
Acta medica (Hradec Králové). Supplementum Universitas Carolina, Facultas Medica Hradec Králové 2001;44(1):3-8.
2001: J Machacková; Michaela Adamcová; Yvona Mazurová; Radomír Hrdina; Milan Nobilis
Evaluation of cardiac effects of the new antineoplastic drug --dimethoxybenfluron--in the rabbit.
Physiological research / Academia Scientiarum Bohemoslovaca 2001;50(5):491-9.
2000: Jarmila Machácková; Vladimír Gersl; Michaela Adamcová; Yvona Mazurová; Radomír Hrdina; M Mĕlka; Milan Nobilis
[Effects of new antineoplastic agents (dimethoxybenflurone and Oracin) on the cardiovascular system and other parameters in the rabbit in vivo].
Acta medica (Hradec Králové). Supplementum Universitas Carolina, Facultas Medica Hradec Králové 2000;43(2):119-38.
2000: Radomír Hrdina; Vladimír Gersl; Ivona Klimtová; T Simůnek; Jarmila Machácková; Michaela Adamcová
Anthracycline-induced cardiotoxicity.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 2000;43(3):75-82.
1999: Vladimír Gersl; Jiri Bajgar; Radomír Hrdina; Yvona Mazurová; Jarmila Machácková; Jaroslav Cerman; P Suba
Cholinesterases in dexrazoxane-treated daunorubicin cardiomyopathy in rabbits.
General physiology and biophysics 1999;18(4):335-46.
1999: Vladimír Gersl; Jaroslav Cerman; P Suba; Yvona Mazurová; Radomír Hrdina; Jarmila Machácková
IGF-I in experimental daunorubicin-induced cardiomyopathy in rabbits.
Human & experimental toxicology 1999;18(3):154-61.
1999: Jarmila Machácková; Vladimír Gersl; Radomír Hrdina; Milan Nobilis; Vladimír Palicka
The influence of dimethoxybenfluron on biochemical and haematological parameters in rabbits.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 1999;42(3):89-92.
1999: Michaela Adamcová; Vladimír Gersl; Radomír Hrdina; M Melka; Yvona Mazurová; Jirina Vávrová; Vladimír Palicka; Z Kokstein
Cardiac troponin T as a marker of myocardial damage caused by antineoplastic drugs in rabbits.
Journal of cancer research and clinical oncology 1999;125(5):268-74.
1998: Radomír Hrdina; Vladimír Gersl; Jirina Vávrová; Magdaléna Holecková; Vladimír Palicka; J Voglová; Yvona Mazurová; Jiri Bajgar
Myocardial elements content and cardiac function after repeated i.v. administration of DMPS in rabbits.
Human & experimental toxicology 1998;17(4):221-4.
1997: Vladimír Gersl; Radomír Hrdina; Jirina Vávrová; Magdaléna Holecková; Vladimír Palicka; J Voglová; Yvona Mazurová; Jiri Bajgar
Effects of repeated administration of dithiol chelating agent--sodium 2,3-dimercapto-1-propanesulphonate (DMPS)--on biochemical and haematological parameters in rabbits.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 1997;40(1):3-8.
1996: Vladimír Gersl; Jiri Bajgar; Otakar Krs; Radomír Hrdina; Vladimír Palicka; Yvona Mazurová
Changes in cholinesterase activities after daunorubicin administration to rabbits.
Human & experimental toxicology 1996;15(10):834-8.
1996: Radomír Hrdina; Vladimír Gersl; D Svoboda
Acute haemodynamic effects of diltiazem and its distribution in relation to the myocardial infarction size.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové 1996;39(3):107-13.
1996: Vladimír Gersl; Yvona Mazurová; Jiri Bajgar; M Mĕlka; Radomír Hrdina; Vladimír Palicka
Lack of cardiotoxicity of a new antineoplastic agent, a synthetic derivative of indenoisochinoline: comparison with daunorubicin in rabbits.
Archives of toxicology 1996;70(10):645-51.
1995: Vladimír Gersl; Jiri Bajgar; Otakar Krs; Radomír Hrdina; Jirina Vávrová; Vladimír Palicka; Jaroslava Voglová; Jaroslav Cerman; P Suba
Changes of some biochemical and hematological parameters following administration of daunorubicin in rabbits.
Sborník vědeckých prací Lékařské fakulty Karlovy univerzity v Hradci Králové. Supplementum 1995;38(2):79-84.
1995: Vladimír Gersl; Jiri Bajgar; Otakar Krs; Radomír Hrdina; Jirina Vávrová; Vladimír Palicka; Jaroslava Voglová; Jaroslav Cerman; P Suba
Changes of some biochemical and hematological parameters following administration of daunorubicin in rabbits.
Sborník vědeckých prací Lékařské fakulty Karlovy university v Hradci Králové 1995;38(2):79-84.
1994: Vladimír Gersl; Radomír Hrdina
Noninvasive polygraphic cardiac changes in daunorubicin-induced cardiomyopathy in rabbits.
Sborník vědeckých prací Lékařské fakulty Karlovy university v Hradci Králové 1994;37(2):49-55.