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Dennis Hruby
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21
Franke, Christine
17
Bolken, Tove'
15
Byrd, Chelsea
11
Jones, Kevin
11
Jordan, Robert
8
Grosenbach, DW
6
King, David
6
Warren, Travis
5
Fischetti, Vincent
4
Dutton, EK
4
Hansen, Scott
4
Yoder, Jennifer
3
Zeller, GO
3
Myscofski, DM
3
Lund, Amanda
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All Publications
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2009: Berhanu Aklile; King David S; Mosier Stacie; Jordan Robert; Jones Kevin F; Hruby Dennis E; Grosenbach Douglas W
ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation.
Antimicrobial agents and chemotherapy 2009;53(12):4999-5009.
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2009: Huggins John; Goff Arthur; Hensley Lisa; Mucker Eric; Shamblin Josh; Wlazlowski Carly; Johnson Wendy; Chapman Jennifer; Larsen Tom; Twenhafel Nancy; Karem Kevin; Damon Inger K; Byrd Chelsea M; Bolken Tove' C; Jordan Robert; Hruby Dennis
Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Antimicrobial agents and chemotherapy 2009;53(6):2620-5.
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2009: Jordan Robert; Goff Arthur; Frimm Annie; Corrado Michael L; Hensley Lisa E; Byrd Chelsea M; Mucker Eric; Shamblin Josh; Bolken Tove' C; Wlazlowski Carly; Johnson Wendy; Chapman Jennifer; Twenhafel Nancy; Tyavanagimatt Shanthakumar; Amantana Adams; Chinsangaram Jarasvech; Hruby Dennis E; Huggins John
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Antimicrobial agents and chemotherapy 2009;53(5):1817-22.
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2008: Larson Ryan A; Dai Dongcheng; Hosack Virginia T; Tan Ying; Bolken Tove' C; Hruby Dennis E; Amberg Sean M
Identification of a broad-spectrum arenavirus entry inhibitor.
Journal of virology 2008;82(21):10768-75.
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2008: Jordan Robert; Tien Deborah; Bolken Tove' C; Jones Kevin F; Tyavanagimatt Shanthakumar R; Strasser Josef; Frimm Annie; Corrado Michael L; Strome Phoebe G; Hruby Dennis E
Single-dose safety and pharmacokinetics of ST-246, a novel orthopoxvirus egress inhibitor.
Antimicrobial agents and chemotherapy 2008;52(5):1721-7.
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2008: Berhanu Aklile; Wilson Rebecca L; Kirkwood-Watts Dana L; King David S; Warren Travis K; Lund Susan A; Brown Lindsay L; Krupkin Alex K; Vandermay Erin; Weimers Will; Honeychurch Kady M; Grosenbach Douglas W; Jones Kevin F; Hruby Dennis E
Vaccination of BALB/c mice with Escherichia coli-expressed vaccinia virus proteins A27L, B5R, and D8L protects mice from lethal vaccinia virus challenge.
Journal of virology 2008;82(7):3517-29.
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2008: Grosenbach Douglas W; Jordan Robert; King David S; Berhanu Aklile; Warren Travis K; Kirkwood-Watts Dana L; Tyavanagimatt Shanthakumar; Tan Ying; Wilson Rebecca L; Jones Kevin F; Hruby Dennis E
Immune responses to the smallpox vaccine given in combination with ST-246, a small-molecule inhibitor of poxvirus dissemination.
Vaccine 2008;26(7):933-46.
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2008: Bolken Tove C; Hruby Dennis E
Discovery and development of antiviral drugs for biodefense: experience of a small biotechnology company.
Antiviral research 2008;77(1):1-5.
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2007: Quenelle Debra C; Prichard Mark N; Keith Kathy A; Hruby Dennis E; Jordan Robert; Painter George R; Robertson Alice; Kern Earl R
Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.
Antimicrobial agents and chemotherapy 2007;51(11):4118-24.
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2007: Katritch Vsevolod; Byrd Chelsea M; Tseitin Vladimir; Dai Dongcheng; Raush Eugene; Totrov Maxim; Abagyan Ruben; Jordan Robert; Hruby Dennis E
Discovery of small molecule inhibitors of ubiquitin-like poxvirus proteinase I7L using homology modeling and covalent docking approaches.
Journal of computer-aided molecular design 2007;21(10-11):549-58.
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2007: Honeychurch Kady M; Yang Guang; Jordan Robert; Hruby Dennis E
The vaccinia virus F13L YPPL motif is required for efficient release of extracellular enveloped virus.
Journal of virology 2007;81(13):7310-5.
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2007: Alzhanova Dina; Hruby Dennis E
A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.
Virology 2007;362(2):421-7.
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2007: Bailey Thomas R; Rippin Susan R; Opsitnick Elizabeth; Burns Christopher J; Pevear Daniel C; Collett Marc S; Rhodes Gerry; Tohan Sanjeev; Huggins John W; Baker Robert O; Kern Earl R; Keith Kathy A; Dai Dongcheng; Yang Guang; Hruby Dennis; Jordan Robert
N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.
Journal of medicinal chemistry 2007;50(7):1442-4.
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2007: Warren Travis K; Lund S Amanda; Jones Kevin F; Hruby Dennis E
Comparison of transformation protocols in Streptococcus gordonii and evaluation of native promoter strength using a multiple-copy plasmid.
Canadian journal of microbiology 2007;53(3):417-26.
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2007: Quenelle Debra C; Buller R M L; Parker Scott; Keith Kathy A; Hruby Dennis E; Jordan Robert; Kern Earl R
Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Antimicrobial agents and chemotherapy 2007;51(2):689-95.
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2007: Yang Su Jung; Hruby Dennis E
Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition.
Virology journal 2007;4():73.
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2006: Alzhanova Dina; Hruby Dennis E
A trans-Golgi network resident protein, golgin-97, accumulates in viral factories and incorporates into virions during poxvirus infection.
Journal of virology 2006;80(23):11520-7.
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2006: Byrd Chelsea M; Hruby Dennis E
Vaccinia virus proteolysis--a review.
Reviews in medical virology 2006;16(3):187-202.
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2006: Bolken Tove C; Laquerre Sylvie; Zhang Yuanming; Bailey Thomas R; Pevear Daniel C; Kickner Shirley S; Sperzel Lindsey E; Jones Kevin F; Warren Travis K; Amanda Lund S; Kirkwood-Watts Dana L; King David S; Shurtleff Amy C; Guttieri Mary C; Deng Yijun; Bleam Maureen; Hruby Dennis E
Identification and characterization of potent small molecule inhibitor of hemorrhagic fever New World arenaviruses.
Antiviral research 2006;69(2):86-97.
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2006: Wilson Rebecca L; Brown Lindsay L; Kirkwood-Watts Dana; Warren Travis K; Lund S Amanda; King David S; Jones Kevin F; Hruby Dennis E
Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence.
Infection and immunity 2006;74(1):765-8.
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2006: Moerdyk Megan J; Byrd Chelsea M; Hruby Dennis E
Analysis of vaccinia virus temperature-sensitive I7L mutants reveals two potential functional domains.
Virology journal 2006;3():64.
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2006: Yoder Jennifer D; Chen Tsefang S; Gagnier Cliff R; Vemulapalli Srilakshmi; Maier Claudia S; Hruby Dennis E
Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins.
Virology journal 2006;3():10.
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2006: Honeychurch Kady M; Byrd Chelsea M; Hruby Dennis E
Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase.
Virology journal 2006;3():7.
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2005: Yang Guang; Pevear Daniel C; Davies Marc H; Collett Marc S; Bailey Tom; Rippen Susan; Barone Linda; Burns Chris; Rhodes Gerry; Tohan Sanjeev; Huggins John W; Baker Robert O; Buller R L Mark; Touchette Erin; Waller Kem; Schriewer Jill; Neyts Johan; DeClercq Erik; Jones Kevin; Hruby Dennis; Jordan Robert
An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge.
Journal of virology 2005;79(20):13139-49.
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2005: Wilson Rebecca L; Hruby Dennis E
Commensal bacteria as a novel delivery system for subunit vaccines directed against agents of bioterrorism.
Advanced drug delivery reviews 2005;57(9):1392-402.
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2005: Kotloff Karen L; Wasserman Steven S; Jones Kevin F; Livio Sofie; Hruby Dennis E; Franke Christine A; Fischetti Vincent A
Clinical and microbiological responses of volunteers to combined intranasal and oral inoculation with a Streptococcus gordonii carrier strain intended for future use as a group A streptococcus vaccine.
Infection and immunity 2005;73(4):2360-6.
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2005: Warren Travis K; Lund S Amanda; Jones Kevin F; Hruby Dennis E
Development of PLEX, a plasmid-based expression system for production of heterologous gene products by the gram-positive bacteria Streptococcus gordonii.
Protein expression and purification 2005;40(2):319-26.
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2005: Blouch Robert E; Byrd Chelsea M; Hruby Dennis E
Importance of disulphide bonds for vaccinia virus L1R protein function.
Virology journal 2005;2():91.
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2005: Byrd Chelsea M; Hruby Dennis E
Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity.
Virology journal 2005;2():63.
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2005: Byrd Chelsea M; Hruby Dennis E
A conditional-lethal vaccinia virus mutant demonstrates that the I7L gene product is required for virion morphogenesis.
Virology journal 2005;2():4.
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2004: Byrd Chelsea M; Bolken Tové C; Mjalli Adnan M; Arimilli Murty N; Andrews Robert C; Rothlein Robert; Andrea Tariq; Rao Mohan; Owens Katrina L; Hruby Dennis E
New class of orthopoxvirus antiviral drugs that block viral maturation.
Journal of virology 2004;78(22):12147-56.
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2004: Hedengren-Olcott Marika; Byrd Chelsea M; Watson Jeffrey; Hruby Dennis E
The vaccinia virus G1L putative metalloproteinase is essential for viral replication in vivo.
Journal of virology 2004;78(18):9947-53.
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2004: Hedengren-Olcott Marika; Hruby Dennis E
Conditional expression of vaccinia virus genes in mammalian cell lines expressing the tetracycline repressor.
Journal of virological methods 2004;120(1):9-12.
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2004: Alzhanov Damir; Barnes Jennifer; Hruby Dennis E; Rockey Daniel D
Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA.
BMC microbiology 2004;4():24.
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2004: Yoder Jennifer D; Chen Tsefang; Hruby Dennis E
Sequence-independent acylation of the vaccinia virus A-type inclusion protein.
Biochemistry 2004;43(26):8297-302.
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2004: Chen Tsefang F; Yoder Jennifer D; Hruby Dennis E
Mass spectrometry analysis of synthetically myristoylated peptides.
European journal of mass spectrometry (Chichester, England) 2004;10(4):501-8.
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2004: Byrd Chelsea M; Hruby Dennis E
Construction of recombinant vaccinia virus: cloning into the thymidine kinase locus.
Methods in molecular biology (Clifton, N.J.) 2004;269():31-40.
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2003: Byrd Chelsea M; Bolken Tove' C; Hruby Dennis E
Molecular dissection of the vaccinia virus I7L core protein proteinase.
Journal of virology 2003;77(20):11279-83.
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2003: Chen Tsefang S; Yoder Jennifer D; Hruby Dennis E
Preparation of a large hydrophobic protein for mass spectrometry analysis: vaccina virus ATI protein.
Analytical biochemistry 2003;315(2):277-80.
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2002: Jones C Hal; Dexter Paul; Evans Amy K; Liu Christopher; Hultgren Scott J; Hruby Dennis E
Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin.
Journal of bacteriology 2002;184(20):5762-71.
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2002: Byrd Chelsea M; Bolken Tove' C; Hruby Dennis E
The vaccinia virus I7L gene product is the core protein proteinase.
Journal of virology 2002;76(17):8973-6.
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2002: Hansen Scott G; Cope Torrey A; Hruby Dennis E
BiZyme: a novel fusion protein-mediating selection of vaccinia virus recombinants by fluorescence and antibiotic resistance.
BioTechniques 2002;32(5):1178, 1180, 1182-7.
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2002: Byrd Chelsea M; Bolken Tove' C; Jones Kevin F; Warren Travis K; Vella Anthony T; McDonald Jenny; King David; Blackwood Zach; Hruby Dennis E
Biological consequences of antigen and cytokine co-expression by recombinant Streptococcus gordonii vaccine vectors.
Vaccine 2002;20(17-18):2197-205.
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2002: Bolken Tové C; Franke Christine A; Jones Kevin F; Bell Richard H; Swanson Ryan M; King David S; Fischetti Vincent A; Hruby Dennis E
Analysis of factors affecting surface expression and immunogenicity of recombinant proteins expressed by gram-positive commensal vectors.
Infection and immunity 2002;70(5):2487-91.
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2001: Geller B L; Wade N; Gilberts T D; Hruby D E; Johanson R; Topisirovic L
Surface expression of the conserved C repeat region of streptococcal M6 protein within the Pip bacteriophage receptor of Lactococcus lactis.
Applied and environmental microbiology 2001;67(12):5370-6.
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2001: Franke C A; Bolken T C; Hruby D E
Studies on the genomic organization of recombinant Streptococcus gordonii and the development of a novel intergenic integration site for foreign gene expression.
Journal of molecular microbiology and biotechnology 2001;3(4):545-55.
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2001: Jones C H; Bolken T C; Jones K F; Zeller G O; Hruby D E
Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes.
Infection and immunity 2001;69(9):5538-45.
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2001: Myscofski D M; Dutton E K; Cantor E; Zhang A; Hruby D E
Cleavage and purification of intein fusion proteins using the Streptococcus gordonii spex system.
Preparative biochemistry & biotechnology 2001;31(3):275-90.
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2001: Bolken T C; Franke C A; Zeller G O; Hruby D E
Identification of an intragenic integration site for foreign gene expression in recombinant Streptococcus gordonii strains.
Applied microbiology and biotechnology 2001;55(2):192-7.
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2001: Bolken T C; Franke C A; Jones K F; Zeller G O; Jones C H; Dutton E K; Hruby D E
Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion.
Infection and immunity 2001;69(1):75-80.
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2000: Myscofski D M; Dutton E K; Bolken T C; Franke C A; Hruby D E
Expression and purification of histidine-tagged proteins from the gram-positive Streptococcus gordonii SPEX system.
Protein expression and purification 2000;20(1):112-23.
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2000: Grosenbach D W; Hansen S G; Hruby D E
Identification and analysis of vaccinia virus palmitylproteins.
Virology 2000;275(1):193-206.
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2000: Dutton E K; Ottum S A; Bolken T C; Franke C A; Hruby D E
Expression of active monomeric and dimeric nuclease A from the gram-positive Streptococcus gordonii surface protein expression system.
Protein expression and purification 2000;19(1):158-72.
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2000: Nevrivy D J; Peterson V J; Avram D; Ishmael J E; Hansen S G; Dowell P; Hruby D E; Dawson M I; Leid M
Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
The Journal of biological chemistry 2000;275(22):16827-36.
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2000: Franke C A; Bolman T M; Ottum S A; Jones K F; Hruby D E
Streptococcus gordonii strains resistant to fluorodeoxyuridine contain mutations in the thymidine kinase gene and are deficient in thymidine kinase activity.
Antimicrobial agents and chemotherapy 2000;44(3):787-9.
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1999: Martin K H; Franke C A; Hruby D E
Novel acylation of poxvirus A-type inclusion proteins.
Virus research 1999;60(2):147-57.
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1999: Hansen S G; Grosenbach D W; Hruby D E
Analysis of the site occupancy constraints of primary amino acid sequences in the motif directing palmitylation of the vaccinia virus 37-kDa envelope protein.
Virology 1999;254(1):124-37.
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1998: Myscofski D M; Hruby D E
SPEX, a system for the expression of recombinant proteins from gram-positive bacterial vectors.
Protein expression and purification 1998;14(3):409-17.
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1998: Grosenbach D W; Hruby D E
Analysis of a vaccinia virus mutant expressing a nonpalmitylated form of p37, a mediator of virion envelopment.
Journal of virology 1998;72(6):5108-20.
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1998: Grosenbach D W; Hruby D E
Biology of vaccinia virus acylproteins.
Frontiers in bioscience : a journal and virtual library 1998;3():d354-64.
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1997: Martin K H; Grosenbach D W; Franke C A; Hruby D E
Identification and analysis of three myristylated vaccinia virus late proteins.
Journal of virology 1997;71(7):5218-26.
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1997: Coyle T C; Franke C A; Hruby D E
Development of a radioactive protein A-based assay for analysis of surface protein expression in gram-positive bacteria.
Applied and environmental microbiology 1997;63(6):2477-80.
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1997: Grosenbach D W; Ulaeto D O; Hruby D E
Palmitylation of the vaccinia virus 37-kDa major envelope antigen. Identification of a conserved acceptor motif and biological relevance.
The Journal of biological chemistry 1997;272(3):1956-64.
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1997: Lee P; Hruby D E
Detection of recombinant protein based on reporter enzyme activity: chloramphenicol acetyltransferase.
Methods in molecular biology (Clifton, N.J.) 1997;63():31-40.
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1996: Ulaeto D; Grosenbach D; Hruby D E
The vaccinia virus 4c and A-type inclusion proteins are specific markers for the intracellular mature virus particle.
Journal of virology 1996;70(6):3372-7.
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1995: Whitehead S S; Bersani N A; Hruby D E
Physical and molecular genetic analysis of the multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein.
The Journal of general virology 1995;76 ( Pt 3)():717-21.
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1995: Lee P; Hruby D E
Analysis of the role of the amino-terminal peptide of vaccinia virus structural protein precursors during proteolytic processing.
Virology 1995;207(1):229-33.
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1995: Ulaeto D; Grosenbach D; Hruby D E
Brefeldin A inhibits vaccinia virus envelopment but does not prevent normal processing and localization of the putative envelopment receptor P37.
The Journal of general virology 1995;76 ( Pt 1)():103-11.
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1994: Whitehead S S; Hruby D E
A transcriptionally controlled trans-processing assay: putative identification of a vaccinia virus-encoded proteinase which cleaves precursor protein P25K.
Journal of virology 1994;68(11):7603-8.
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1994: Ravanello M P; Hruby D E
Conditional lethal expression of the vaccinia virus L1R myristylated protein reveals a role in virion assembly.
Journal of virology 1994;68(10):6401-10.
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1994: Ulaeto D; Hruby D E
Uses of vaccinia virus in vaccine delivery.
Current opinion in biotechnology 1994;5(5):501-4.
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1994: Ravanello M P; Hruby D E
Characterization of the vaccinia virus L1R myristylprotein as a component of the intracellular virion envelope.
The Journal of general virology 1994;75 ( Pt 6)():1479-83.
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1994: Whitehead S S; Hruby D E
Differential utilization of a conserved motif for the proteolytic maturation of vaccinia virus proteins.
Virology 1994;200(1):154-61.
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1994: Lee P; Hruby D E
Proteolytic cleavage of vaccinia virus virion proteins. Mutational analysis of the specificity determinants.
The Journal of biological chemistry 1994;269(11):8616-22.
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1994: Vanslyke J K; Hruby D E
Immunolocalization of vaccinia virus structural proteins during virion formation.
Virology 1994;198(2):624-35.
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1993: Vanslyke J K; Lee P; Wilson E M; Hruby D E
Isolation and analysis of vaccinia virus previrions.
Virus genes 1993;7(4):311-24.
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1993: Hruby D E
Vaccinia virus: a novel approach for molecular engineering of peptide vaccines.
Seminars in hematology 1993;30(4 Suppl 4):35-43; discussion 44.
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1993: Lee P; Hruby D E
trans processing of vaccinia virus core proteins.
Journal of virology 1993;67(7):4252-63.
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1993: Child S J; Hruby D E
Further characterization of an adenosine-containing modification of vaccinia virus proteins.
Biochimica et biophysica acta 1993;1157(2):217-28.
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1993: Franke C A; Hruby D E
Expression and single-step purification of enzymatically active vaccinia virus thymidine kinase containing an engineered oligohistidine domain by immobilized metal affinity chromatography.
Protein expression and purification 1993;4(2):101-9.
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1993: Ravanello M P; Franke C A; Hruby D E
An NH2-terminal peptide from the vaccinia virus L1R protein directs the myristylation and virion envelope localization of a heterologous fusion protein.
The Journal of biological chemistry 1993;268(10):7585-93.
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1993: Hruby D E; Franke C A
Viral acylproteins: greasing the wheels of assembly.
Trends in microbiology 1993;1(1):20-5.
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1992: Child S J; Hruby D E
Evidence for multiple species of vaccinia virus-encoded palmitylated proteins.
Virology 1992;191(1):262-71.
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1992: Spriggs M K; Hruby D E; Maliszewski C R; Pickup D J; Sims J E; Buller R M; VanSlyke J
Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein.
Cell 1992;71(1):145-52.
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1992: Black M E; Hruby D E
A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase.
The Journal of biological chemistry 1992;267(14):9743-8.
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1992: Black M E; Hruby D E
Site-directed mutagenesis of a conserved domain in vaccinia virus thymidine kinase. Evidence for a potential role in magnesium binding.
The Journal of biological chemistry 1992;267(10):6801-6.
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1992: Hruby D E; Wilson E M
Use of fluorescent chloramphenicol derivative as a substrate for chloramphenicol acetyltransferase assays.
Methods in enzymology 1992;216():369-76.
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1991: Vanslyke J K; Whitehead S S; Wilson E M; Hruby D E
The multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein: a degenerate conserved cleavage motif within core proteins.
Virology 1991;183(2):467-78.
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1991: Hruby D E; Schneewind O; Wilson E M; Fischetti V A
Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3190-4.
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1991: Black M E; Hruby D E
Nucleotide sequence of the Escherichia coli thymidine kinase gene provides evidence for conservation of functional domains and quaternary structure.
Molecular microbiology 1991;5(2):373-9.
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1991: VanSlyke J K; Franke C A; Hruby D E
Proteolytic maturation of vaccinia virus core proteins: identification of a conserved motif at the N termini of the 4b and 25K virion proteins.
The Journal of general virology 1991;72 ( Pt 2)():411-6.
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1990: Franke C A; Wilson E M; Hruby D E
Use of a cell-free system to identify the vaccinia virus L1R gene product as the major late myristylated virion protein M25.
Journal of virology 1990;64(12):5988-96.
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1990: Black M E; Hruby D E
Identification of the ATP-binding domain of vaccinia virus thymidine kinase.
The Journal of biological chemistry 1990;265(29):17584-92.
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1990: Black M E; Hruby D E
Quaternary structure of vaccinia virus thymidine kinase.
Biochemical and biophysical research communications 1990;169(3):1080-6.
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1990: Miner J N; Tamin A; Hruby D E
Anchoring a vaccinia virus promoter in the nucleus prevents its trans-activation by viral infection.
Virus genes 1990;3(4):355-9.
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1990: Hruby D E
Vaccinia virus vectors: new strategies for producing recombinant vaccines.
Clinical microbiology reviews 1990;3(2):153-70.
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1990: Hruby D E; Brinkley J M; Kang H C; Haugland R P; Young S L; Melner M H
Use of a fluorescent chloramphenicol derivative as a substrate for CAT assays.
BioTechniques 1990;8(2):170-1.
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1990: Child S J; Palumbo G J; Buller R M; Hruby D E
Insertional inactivation of the large subunit of ribonucleotide reductase encoded by vaccinia virus is associated with reduced virulence in vivo.
Virology 1990;174(2):625-9.
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1990: Miner J N; Hruby D E
Vaccinia virus: a versatile tool for molecular biologists.
Trends in biotechnology 1990;8(1):20-5.
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1990: VanSlyke J K; Hruby D E
Posttranslational modification of vaccinia virus proteins.
Current topics in microbiology and immunology 1990;163():185-206.
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1989: Black M E; Wilson E M; Hruby D E
A simple sequencing gel-saving tip.
BioTechniques 1989;7(10):1083.
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1989: Tengelsen L A; Hruby D E
Nucleotide sequence and transcriptional studies of the vaccinia virus KpnI I DNA fragment.
Virus genes 1989;3(2):175-87.
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1989: Franke C A; Reynolds P L; Hruby D E
Fatty acid acylation of vaccinia virus proteins.
Journal of virology 1989;63(10):4285-91.
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1989: Fischetti V A; Hodges W M; Hruby D E
Protection against streptococcal pharyngeal colonization with a vaccinia: M protein recombinant.
Science (New York, N.Y.) 1989;244(4911):1487-90.
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1989: Miner J N; Hruby D E
DNA sequences that regulate expression of a vaccinia virus late gene (L65) and interact with a DNA-binding protein from infected cells.
Journal of virology 1989;63(6):2726-36.
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1989: Miner J N; Hruby D E
Rifampicin prevents virosome localization of L65, an essential vaccinia virus polypeptide.
Virology 1989;170(1):227-37.
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1989: Wilson E M; Franke C A; Black M E; Hruby D E
Expression vector pT7:TKII for the synthesis of authentic biologically active RNA encoding vaccinia virus thymidine kinase.
Gene 1989;77(1):69-78.
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1988: Wilson E M; Edbauer C; Hruby D E
Characterization of a binding factor that interacts with the sequences upstream of the vaccinia virus thymidine kinase gene.
Virus genes 1988;2(1):31-48.
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1988: Hruby D E
Present and future applications of vaccinia virus as a vector.
Veterinary parasitology 1988;29(2-3):281-92.
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1988: Hruby D E; Hodges W M; Wilson E M; Franke C A; Fischetti V A
Expression of streptococcal M protein in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5714-7.
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1988: Tamin A; Villarreal E C; Weinrich S L; Hruby D E
Nucleotide sequence and molecular genetic analysis of the vaccinia virus HindIII N/M region encoding the genes responsible for resistance to alpha-amanitin.
Virology 1988;165(1):141-50.
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1988: Tengelsen L A; Slabaugh M B; Bibler J K; Hruby D E
Nucleotide sequence and molecular genetic analysis of the large subunit of ribonucleotide reductase encoded by vaccinia virus.
Virology 1988;164(1):121-31.
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1988: Child S J; Franke C A; Hruby D E
Inhibition of vaccinia virus replication by nicotinamide: evidence for ADP-ribosylation of viral proteins.
Virus research 1988;9(2-3):119-32.
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1988: Franke C A; Hruby D E
Use of the gene encoding neomycin phosphotransferase II to convect linked markers into the vaccinia virus genome.
Nucleic acids research 1988;16(4):1634.
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1988: Miner J N; Weinrich S L; Hruby D E
Molecular dissection of cis-acting regulatory elements from 5'-proximal regions of a vaccinia virus late gene cluster.
Journal of virology 1988;62(1):297-304.
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1987: Roseman N A; Hruby D E
Nucleotide sequence and transcript organization of a region of the vaccinia virus genome which encodes a constitutively expressed gene required for DNA replication.
Journal of virology 1987;61(5):1398-406.
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1987: Hruby D E; Thomas G
Use of vaccinia virus to express biopharmaceutical products.
Pharmaceutical research 1987;4(2):92-7.
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1987: Hodges W M; Hruby D E
Cell-free translation of a chimeric eucaryotic-procaryotic message yields functional chloramphenicol acetyltransferase.
Analytical biochemistry 1987;160(1):65-7.
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1986: Villarreal E C; Hruby D E
Mapping the genomic location of the gene encoding alpha-amanitin resistance in vaccinia virus mutants.
Journal of virology 1986;57(1):65-70.
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1986: Wilson E M; Hodges W M; Hruby D E
Construction of recombinant vaccinia virus strains using single-stranded DNA insertion vectors.
Gene 1986;49(2):207-13.
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1985: Franke C A; Roseman N A; Hruby D E
Expression and regulation of the vaccinia virus thymidine kinase gene in non-permissive cells.
Virus research 1985;3(1):13-7.
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1984: Villarreal E C; Roseman N A; Hruby D E
Isolation of vaccinia virus mutants capable of replicating independently of the host cell nucleus.
Journal of virology 1984;51(2):359-66.
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