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Christine Hrycyna

Research Profile

Chemicals & Drugs

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Saccharomyces cerevisiae

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Publications

TOP 3
Susan Michaelis; Christine A Hrycyna
Biochemistry. A protease for the ages.
Jemima Barrowman; Christine A Hrycyna; Sarah E Hudon-Miller; Patricia A Wiley; Susan Michaelis
Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.
Jerrin Kuriakose; Christine A Hrycyna; Jean Chmielewski
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.

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All Publications

2013: Susan Michaelis; Christine A Hrycyna
Biochemistry. A protease for the ages.
Science (New York, N.Y.) 2013;339(6127):1529-30.
2012: Jemima Barrowman; Christine A Hrycyna; Sarah E Hudon-Miller; Patricia A Wiley; Susan Michaelis
Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity.
Human molecular genetics 2012;21(18):4084-93.
2012: Jerrin Kuriakose; Christine A Hrycyna; Jean Chmielewski
Click chemistry-derived bivalent quinine inhibitors of P-glycoprotein-mediated cellular efflux.
Bioorganic & medicinal chemistry letters 2012;22(13):4410-2.
2012: Kalub Hahne; Mark D Distefano; James L Donelson; Richard A Gibbs; Liza Shrestha; Jeffrey S Vervacke; Christine A Hrycyna
Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes.
Biochemical and biophysical research communications 2012;423(1):98-103.
2012: Sandy Y Chang; Emily Farber; Douglas A Andres; Christine A Hrycyna; Sarah E Hudon-Miller; Hea-Jin Jung; John M Lee; H Peter Spielmann; Thangaiah Subramanian; Shao H Yang; Stephen G Young; Loren G Fong
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.
Journal of lipid research 2012;53(6):1176-82.
2012: Hilda A Namanja; Christopher Campos; David A Davis; Dana Emmert; Christine A Hrycyna; David S Miller; Jean Chmielewski
Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers.
Journal of the American Chemical Society 2012;134(6):2976-80.
2011: Joel A Bergman; Kalub Hahne; Christine A Hrycyna; Richard A Gibbs
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(18):5616-9.
2011: Jaimeen D Majmudar; Kalub Hahne; Christine A Hrycyna; Richard A Gibbs
Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(9):2616-20.
2011: Anna Jacobs; Dana Emmert; Svenja Wieschrath; Christine A Hrycyna; Michael Wiese
Recombinant synthesis of human ABCG2 expressed in the yeast Saccharomyces cerevisiae: an experimental methodological study.
The protein journal 2011;30(3):201-11.
2010: Amy M Griggs; Kalub Hahne; Christine A Hrycyna
Functional oligomerization of the Saccharomyces cerevisiae isoprenylcysteine carboxyl methyltransferase, Ste14p.
The Journal of biological chemistry 2010;285(18):13380-7.
2009: Hilda Namanja; Dana Emmert; Marcos M Pires; Christine A Hrycyna; Jean Chmielewski
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Biochemical and biophysical research communications 2009;388(4):672-6.
2009: James L Donelson; Heather B Hodges-Loaiza; Brian S Henriksen; Christine A Hrycyna; Richard A Gibbs
Solid-phase synthesis of prenylcysteine analogs.
The Journal of organic chemistry 2009;74(8):2975-81.
2008: Sarah E Hudon; Catherine Coffinier; Susan Michaelis; Loren G Fong; Stephen G Young; Christine A Hrycyna
HIV-protease inhibitors block the enzymatic activity of purified Ste24p.
Biochemical and biophysical research communications 2008;374(2):365-8.
2008: Catherine Coffinier; Sarah E Hudon; Roger Lee; Emily A Farber; Chika Nobumori; Jeffrey H Miner; Douglas A Andres; H Peter Spielmann; Christine A Hrycyna; Loren G Fong; Stephen G Young
A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.
The Journal of biological chemistry 2008;283(15):9797-804.
2007: Catherine Coffinier; Sarah E Hudon; Emily A Farber; Sandy Y Chang; Christine A Hrycyna; Stephen G Young; Loren G Fong
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(33):13432-7.
2007: Kazumasa Takenaka; Jessica A Morgan; George L Scheffer; Masashi Adachi; Clinton F Stewart; Daxi Sun; Markos Leggas; Karin F K Ejendal; Christine A Hrycyna; John D Schuetz
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution.
Cancer research 2007;67(14):6965-72.
2006: Wilma Febo-Ayala; Shakira L Morera-Félix; Christine A Hrycyna; David H Thompson
Functional reconstitution of the integral membrane enzyme, isoprenylcysteine carboxyl methyltransferase, in synthetic bolalipid membrane vesicles.
Biochemistry 2006;45(49):14683-94.
2006: Michael H Gelb; Luc Brunsveld; Christine A Hrycyna; Susan Michaelis; Fuyuhiko Tamanoi; Wesley C Van Voorhis; Herbert Waldmann
Therapeutic intervention based on protein prenylation and associated modifications.
Nature chemical biology 2006;2(10):518-28.
2006: Marcos M Pires; Christine A Hrycyna; Jean Chmielewski
Bivalent probes of the human multidrug transporter P-glycoprotein.
Biochemistry 2006;45(38):11695-702.
2006: James L Donelson; Heather B Hodges; Daniel D Macdougall; Brian S Henriksen; Christine A Hrycyna; Richard A Gibbs
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.
Bioorganic & medicinal chemistry letters 2006;16(16):4420-3.
2006: Karin F K Ejendal; Ndeye Khady Diop; Linda C Schweiger; Christine A Hrycyna
The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding.
Protein science : a publication of the Protein Society 2006;15(7):1597-607.
2005: Brian S Henriksen; Jessica Anderson; Christine A Hrycyna; Richard A Gibbs
Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity.
Bioorganic & medicinal chemistry letters 2005;15(22):5080-3.
2005: Markus Geisler; Joshua J Blakeslee; Rodolphe Bouchard; Ok Ran Lee; Vincent Vincenzetti; Anindita Bandyopadhyay; Boosaree Titapiwatanakun; Wendy Ann Peer; Aurélien Bailly; Elizabeth L Richards; Karin F K Ejendal; Aaron P Smith; Célia Baroux; Ueli Grossniklaus; Axel Müller; Christine A Hrycyna; Robert Dudler; Angus S Murphy; Enrico Martinoia
Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.
The Plant journal : for cell and molecular biology 2005;44(2):179-94.
2005: Jessica Anderson; Brian S Henriksen; Richard A Gibbs; Christine A Hrycyna
The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors.
The Journal of biological chemistry 2005;280(33):29454-61.
2005: Aarti Bhatia; Hans-Jochen Schäfer; Christine A Hrycyna
Oligomerization of the human ABC transporter ABCG2: evaluation of the native protein and chimeric dimers.
Biochemistry 2005;44(32):10893-904.
2005: Nadya I Tarasova; Rishi Seth; Sergey G Tarasov; Teresa Kosakowska-Cholody; Christine A Hrycyna; Michael M Gottesman; Christopher J Michejda
Transmembrane inhibitors of P-glycoprotein, an ABC transporter.
Journal of medicinal chemistry 2005;48(11):3768-75.
2005: Caihua Wang; Scott Leffler; David H Thompson; Christine A Hrycyna
A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases.
Biochemical and biophysical research communications 2005;331(1):351-6.
2005: Heather B Hodges; Mingkang Zhou; Saubhik Haldar; Jessica Anderson; David H Thompson; Christine A Hrycyna
Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator.
Bioconjugate chemistry 2005;16(3):490-3.
2005: Ndeye K Diop; Christine A Hrycyna
N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane.
Biochemistry 2005;44(14):5420-9.
2005: Douglas P Corrigan; Danuta Kuszczak; Antonio Rusiñol; Douglas P Thewke; Christine A Hrycyna; Susan Michaelis; Michael S Sinensky
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.
The Biochemical journal 2005;387(Pt 1):129-38.
2005: Karin F K Ejendal; Christine A Hrycyna
Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A.
Molecular pharmacology 2005;67(3):902-11.
2005: Jessica Anderson; Hilary Frase; Susan Michaelis; Christine A Hrycyna
Purification, functional reconstitution, and characterization of the Saccharomyces cerevisiae isoprenylcysteine carboxylmethyltransferase Ste14p.
The Journal of biological chemistry 2005;280(8):7336-45.
2002: Karin F K Ejendal; Christine A Hrycyna
Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.
Current protein & peptide science 2002;3(5):503-11.
2001: Christine A Hrycyna
Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.
Seminars in cell & developmental biology 2001;12(3):247-56.