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CA Hrycyna

Research Profile

Chemicals & Drugs

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Yasumasa Honjo; CA Hrycyna; Q W Yan; Wilma Y Medina-Pérez; Robert W Robey; A van de Laar; Thomas Litman; Michael Dean; Susan E Bates
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
J J Gribar; M Ramachandra; CA Hrycyna; S Dey; Suresh V Ambudkar
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
CA Hrycyna; M Ramachandra; ursula germann; P W Cheng; Ira Pastan; Michael M Gottesman
Both ATP sites of human P-glycoprotein are essential but not symmetric.

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2001: Yasumasa Honjo; CA Hrycyna; Q W Yan; Wilma Y Medina-Pérez; Robert W Robey; A van de Laar; Thomas Litman; Michael Dean; Susan E Bates
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer research 2001;61(18):6635-9.
2000: J J Gribar; M Ramachandra; CA Hrycyna; S Dey; Suresh V Ambudkar
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
The Journal of membrane biology 2000;173(3):203-14.
1999: CA Hrycyna; M Ramachandra; ursula germann; P W Cheng; Ira Pastan; Michael M Gottesman
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Biochemistry 1999;38(42):13887-99.
1999: Suresh V Ambudkar; S Dey; CA Hrycyna; M Ramachandra; Ira Pastan; Michael M Gottesman
Biochemical, cellular, and pharmacological aspects of the multidrug transporter.
Annual review of pharmacology and toxicology 1999;39():361-98.
1998: P Hafkemeyer; S Dey; Suresh V Ambudkar; CA Hrycyna; Ira Pastan; Michael M Gottesman
Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.
Biochemistry 1998;37(46):16400-9.
1998: G Russ; M Ramachandra; CA Hrycyna; Michael M Gottesman; Ira Pastan; Jack R Bennink; jon yewdell
P-glycoprotein plays an insignificant role in the presentation of antigenic peptides to CD8+ T cells.
Cancer research 1998;58(20):4688-93.
1998: CA Hrycyna; L E Airan; ursula germann; Suresh V Ambudkar; Ira Pastan; Michael M Gottesman
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Biochemistry 1998;37(39):13660-73.
1998: CA Hrycyna; M Ramachandra; Suresh V Ambudkar; Y H Ko; Peter L Pedersen; Ira Pastan; Michael M Gottesman
Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.
The Journal of biological chemistry 1998;273(27):16631-4.
1998: M Ramachandra; Suresh V Ambudkar; D Chen; CA Hrycyna; S Dey; Michael M Gottesman; Ira Pastan
Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.
Biochemistry 1998;37(14):5010-9.
1998: CA Hrycyna; Michael M Gottesman
Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(2):81-3.
1998: CA Hrycyna; M Ramachandra; Ira Pastan; Michael M Gottesman
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Methods in enzymology 1998;292():456-73.
1996: M Ramachandra; Suresh V Ambudkar; Michael M Gottesman; Ira Pastan; CA Hrycyna
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Molecular biology of the cell 1996;7(10):1485-98.
1995: G L Evans; B Ni; CA Hrycyna; D Chen; Suresh V Ambudkar; Ira Pastan; ursula germann; Michael M Gottesman
Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.
Journal of bioenergetics and biomembranes 1995;27(1):43-52.
1995: Michael M Gottesman; CA Hrycyna; Patricia V Schoenlein; ursula germann; Ira Pastan
Genetic analysis of the multidrug transporter.
Annual review of genetics 1995;29():607-49.
1995: CA Hrycyna; S J Wait; P S Backlund; Susan Michaelis
Yeast STE14 methyltransferase, expressed as TrpE-STE14 fusion protein in Escherichia coli, for in vitro carboxylmethylation of prenylated polypeptides.
Methods in enzymology 1995;250():251-66.
1994: CA Hrycyna; M C Yang; Steven Clarke
Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways.
Biochemistry 1994;33(32):9806-12.
1993: CA Hrycyna; Steven Clarke
Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae.
Biochemistry 1993;32(42):11293-301.
1993: CA Hrycyna; Steven Clarke
Modification of eukaryotic signaling proteins by C-terminal methylation reactions.
Pharmacology & therapeutics 1993;59(3):281-300.
1992: CA Hrycyna; Steven Clarke
Maturation of isoprenylated proteins in Saccharomyces cerevisiae. Multiple activities catalyze the cleavage of the three carboxyl-terminal amino acids from farnesylated substrates in vitro.
The Journal of biological chemistry 1992;267(15):10457-64.
1991: CA Hrycyna; S K Sapperstein; Steven Clarke; Susan Michaelis
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.
The EMBO journal 1991;10(7):1699-709.
1990: CA Hrycyna; Steven Clarke
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.
Molecular and cellular biology 1990;10(10):5071-6.