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Gary Ackers

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Occupations

Thermodynamics

Chemicals & Drugs

Physiology

Allosteric Regulation

Concepts & Ideas

Living Beings

Bacteriophage lambda

Phenomena

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Network (preview)

Co-Publications
Name
17
Holt, Jo
12
Doyle, Michael
6
LiCata, Vince
5
Senear, Donald
4
Turner, George
4
Klinger, Alexandra
4
Beckett, Dorothy
4
Brenowitz, Michael
3
Huang, Y
3
Noble, Robert
2
Wierzba, Anita
2
Yarian, Connie
2
Denisov, Ilia
2
Kliger, David
2
Kwiatkowski, Laura

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Publications

TOP 3
Ackers Gary K; Holt Jo M
Asymmetric cooperativity in a symmetric tetramer: human hemoglobin.
Holt Jo M; Ackers Gary K
Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 2. Stepwise cooperative free energy.
Holt Jo M; Klinger Alexandra L; Yarian Connie S; Keelara Varsha; Ackers Gary K
Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 1. Cooperative and noncooperative oxygen binding in Zn-substituted hemoglobin.

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All Publications

2006: Ackers Gary K; Holt Jo M
Asymmetric cooperativity in a symmetric tetramer: human hemoglobin.
The Journal of biological chemistry 2006;281(17):11441-3.
2005: Holt Jo M; Ackers Gary K
Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 2. Stepwise cooperative free energy.
Biochemistry 2005;44(36):11939-49.
2005: Holt Jo M; Klinger Alexandra L; Yarian Connie S; Keelara Varsha; Ackers Gary K
Asymmetric distribution of cooperativity in the binding cascade of normal human hemoglobin. 1. Cooperative and noncooperative oxygen binding in Zn-substituted hemoglobin.
Biochemistry 2005;44(36):11925-38.
2004: Goldbeck Robert A; Esquerra Raymond M; Kliger David S; Holt Jo M; Ackers Gary K
The molecular code for hemoglobin allostery revealed by linking the thermodynamics and kinetics of quaternary structural change. 2. Cooperative free energies of (alphaFeCObetaFe)2 and (alphaFebetaFeCO)2 T-state tetramers.
Biochemistry 2004;43(38):12065-80.
2004: Goldbeck Robert A; Esquerra Raymond M; Holt Jo M; Ackers Gary K; Kliger David S
The molecular code for hemoglobin allostery revealed by linking the thermodynamics and kinetics of quaternary structural change. 1. Microstate linear free energy relations.
Biochemistry 2004;43(38):12048-64.
2004: Ackers Gary K; Holt Jo M; Burgie E Sethe; Yarian Connie S
Analyzing intermediate state cooperativity in hemoglobin.
Methods in enzymology 2004;379():3-28.
2002: Ackers Gary K; Dalessio Paula M; Lew George H; Daugherty Margaret A; Holt Jo M
Single residue modification of only one dimer within the hemoglobin tetramer reveals autonomous dimer function.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9777-82.
2001: Kaufman R M; Lu Z H; Behl R; Holt J M; Ackers G K; Ley T J
Lack of neighborhood effects from a transcriptionally active phosphoglycerate kinase-neo cassette located between the murine beta-major and beta-minor globin genes.
Blood 2001;98(1):65-73.
2000: Darling P J; Holt J M; Ackers G K
Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers.
Journal of molecular biology 2000;302(3):625-38.
2000: Darling P J; Holt J M; Ackers G K
Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding I: analysis of cro dimerization from nanomolar to micromolar concentrations.
Biochemistry 2000;39(37):11500-7.
2000: Ackers G K; Holt J M; Huang Y; Grinkova Y; Klinger A L; Denisov I
Confirmation of a unique intra-dimer cooperativity in the human hemoglobin alpha(1)beta(1)half-oxygenated intermediate supports the symmetry rule model of allosteric regulation.
Proteins 2000;Suppl 4():23-43.
1999: Hui H L; Kavanaugh J S; Doyle M L; Wierzba A; Rogers P H; Arnone A; Holt J M; Ackers G K; Noble R W
Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli.
Biochemistry 1999;38(3):1040-9.
1998: Pray T R; Burz D S; Ackers G K
Cooperative non-specific DNA binding by octamerizing lambda cI repressors: a site-specific thermodynamic analysis.
Journal of molecular biology 1998;282(5):947-58.
1998: Bain D L; Ackers G K
A quantitative cryogenic gel-shift technique for analysis of protein-DNA binding.
Analytical biochemistry 1998;258(2):240-5.
1998: Kiger L; Klinger A L; Kwiatkowski L D; De Young A; Doyle M L; Holt J M; Noble R W; Ackers G K
Thermodynamic studies on the equilibrium properties of a series of recombinant betaW37 hemoglobin mutants.
Biochemistry 1998;37(13):4336-45.
1998: Merabet E K; Burz D S; Ackers G K
Thermal melting properties of C-terminal domain mutants of bacteriophage lambda cI repressor.
Methods in enzymology 1998;295():450-67.
1998: Klinger A L; Ackers G K
Analysis of spectra from multiwavelength oxygen-binding studies of mixed metal hybrid hemoglobins.
Methods in enzymology 1998;295():190-207.
1998: Ackers G K
Deciphering the molecular code of hemoglobin allostery.
Advances in protein chemistry 1998;51():185-253.
1997: Abraham D J; Kellogg G E; Holt J M; Ackers G K
Hydropathic analysis of the non-covalent interactions between molecular subunits of structurally characterized hemoglobins.
Journal of molecular biology 1997;272(4):613-32.
1997: Ackers G K; Perrella M; Holt J M; Denisov I; Huang Y
Thermodynamic stability of the asymmetric doubly-ligated hemoglobin tetramer (alpha+CNbeta+CN)(alphabeta): methodological and mechanistic issues.
Biochemistry 1997;36(36):10822-9.
1997: Ackers G K; Bolen D W
The Gibbs conference on biothermodynamics: origins and evolution.
Biophysical chemistry 1997;64(1-3):3-5.
1997: Doyle M L; Holt J M; Ackers G K
Effects of NaCl on the linkages between O2 binding and subunit assembly in human hemoglobin: titration of the quaternary enhancement effect.
Biophysical chemistry 1997;64(1-3):271-87.
1997: Huang Y; Koestner M L; Ackers G K
Tertiary and quaternary chloride effects of the partially ligated (CN-met) hemoglobin intermediates.
Biophysical chemistry 1997;64(1-3):157-73.
1996: Huang Y; Koestner M L; Ackers G K
Heterotropic effects of chloride on the ligation microstates of hemoglobin at constant water activity.
Biophysical journal 1996;71(4):2106-16.
1996: Huang Y; Doyle M L; Ackers G K
The oxygen-binding intermediates of human hemoglobin: evaluation of their contributions to cooperativity using zinc-containing hybrids.
Biophysical journal 1996;71(4):2094-105.
1996: Huang Y; Yonetani T; Tsuneshige A; Hoffman B M; Ackers G K
Heterometallic hybrids of homometallic human hemoglobins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4425-30.
1996: Burz D S; Ackers G K
Cooperativity mutants of bacteriophage lambda cI repressor: temperature dependence of self-assembly.
Biochemistry 1996;35(10):3341-50.
1996: Huang Y; Ackers G K
Transformation of cooperative free energies between ligation systems of hemoglobin: resolution of the carbon monoxide binding intermediates.
Biochemistry 1996;35(3):704-18.
1995: Merabet E; Ackers G K
Calorimetric analysis of lambda cI repressor binding to DNA operator sites.
Biochemistry 1995;34(27):8554-63.
1995: Huang Y; Ackers G K
Enthalpic and entropic components of cooperativity for the partially ligated intermediates of hemoglobin support a "symmetry rule" mechanism.
Biochemistry 1995;34(19):6316-27.
1995: LiCata V J; Ackers G K
Long-range, small magnitude nonadditivity of mutational effects in proteins.
Biochemistry 1995;34(10):3133-9.
1995: Holt J M; Ackers G K
The pathway of allosteric control as revealed by hemoglobin intermediate states.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(2):210-8.
1994: Bain D L; Ackers G K
Self-association and DNA binding of lambda cI repressor N-terminal domains reveal linkage between sequence-specific binding and the C-terminal cooperativity domain.
Biochemistry 1994;33(49):14679-89.
1994: Daugherty M A; Shea M A; Ackers G K
Bohr effects of the partially-ligated (CN-met) intermediates of hemoglobin as probed by quaternary assembly.
Biochemistry 1994;33(34):10345-57.
1994: Burz D S; Ackers G K
Single-site mutations in the C-terminal domain of bacteriophage lambda cI repressor alter cooperative interactions between dimers adjacently bound to OR.
Biochemistry 1994;33(28):8406-16.
1994: Burz D S; Beckett D; Benson N; Ackers G K
Self-assembly of bacteriophage lambda cI repressor: effects of single-site mutations on the monomer-dimer equilibrium.
Biochemistry 1994;33(28):8399-405.
1994: Doyle M L; Myers D W; Ackers G K; Shrager R I
Weighted nonlinear regression analysis of highly cooperative oxygen equilibrium curves.
Methods in enzymology 1994;232():576-97.
1993: LiCata V J; Dalessio P M; Ackers G K
Single-site modifications of half-ligated hemoglobin reveal autonomous dimer cooperativity within a quaternary T tetramer.
Proteins 1993;17(3):279-96.
1993: Beckett D; Burz D S; Ackers G K; Sauer R T
Isolation of lambda repressor mutants with defects in cooperative operator binding.
Biochemistry 1993;32(35):9073-9.
1992: Doyle M L; Ackers G K
Cooperative oxygen binding, subunit assembly, and sulfhydryl reaction kinetics of the eight cyanomet intermediate ligation states of human hemoglobin.
Biochemistry 1992;31(45):11182-95.
1992: Doyle M L; Lew G; Turner G J; Rucknagel D; Ackers G K
Regulation of oxygen affinity by quaternary enhancement: does hemoglobin Ypsilanti represent an allosteric intermediate?
Proteins 1992;14(3):351-62.
1992: Turner G J; Galacteros F; Doyle M L; Hedlund B; Pettigrew D W; Turner B W; Smith F R; Moo-Penn W; Rucknagel D L; Ackers G K
Mutagenic dissection of hemoglobin cooperativity: effects of amino acid alteration on subunit assembly of oxy and deoxy tetramers.
Proteins 1992;14(3):333-50.
1992: Doyle M L; Lew G; De Young A; Kwiatkowski L; Wierzba A; Noble R W; Ackers G K
Functional properties of human hemoglobins synthesized from recombinant mutant beta-globins.
Biochemistry 1992;31(36):8629-39.
1992: Englander S W; Englander J J; McKinnie R E; Ackers G K; Turner G J; Westrick J A; Gill S J
Hydrogen exchange measurement of the free energy of structural and allosteric change in hemoglobin.
Science (New York, N.Y.) 1992;256(5064):1684-7.
1992: Doyle M L; Ackers G K
Weighting functions and parameter resolvability for oxygenation data subject to error in the independent variable.
Biophysical chemistry 1992;42(3):271-81.
1992: Ackers G K; Doyle M L; Myers D; Daugherty M A
Molecular code for cooperativity in hemoglobin.
Science (New York, N.Y.) 1992;255(5040):54-63.
1992: Koblan K S; Ackers G K
Site-specific enthalpic regulation of DNA transcription at bacteriophage lambda OR.
Biochemistry 1992;31(1):57-65.
1992: Koblan K S; Bain D L; Beckett D; Shea M A; Ackers G K
Analysis of site-specific interaction parameters in protein-DNA complexes.
Methods in enzymology 1992;210():405-25.
1991: Koblan K S; Ackers G K
Cooperative protein-DNA interactions: effects of KCl on lambda cI binding to OR.
Biochemistry 1991;30(31):7822-7.
1991: Koblan K S; Ackers G K
Energetics of subunit dimerization in bacteriophage lambda cI repressor: linkage to protons, temperature, and KCl.
Biochemistry 1991;30(31):7817-21.
1991: Beckett D; Koblan K S; Ackers G K
Quantitative study of protein association at picomolar concentrations: the lambda phage cl repressor.
Analytical biochemistry 1991;196(1):69-75.
1991: Doyle M L; Speros P C; LiCata V J; Gingrich D; Hoffman B M; Ackers G K
Linkage between cooperative oxygenation and subunit assembly of cobaltous human hemoglobin.
Biochemistry 1991;30(29):7263-71.
1991: Speros P C; LiCata V J; Yonetani T; Ackers G K
Experimental resolution of cooperative free energies for the ten ligation species of cobalt(II)/iron(II)-CO hemoglobin.
Biochemistry 1991;30(29):7254-62.
1991: Daugherty M A; Shea M A; Johnson J A; LiCata V J; Turner G J; Ackers G K
Identification of the intermediate allosteric species in human hemoglobin reveals a molecular code for cooperative switching.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1110-4.
1990: LiCata V J; Speros P C; Rovida E; Ackers G K
Direct and indirect pathways of functional coupling in human hemoglobin are revealed by quantitative low-temperature isoelectric focusing of mutant hybrids.
Biochemistry 1990;29(42):9771-83.
1990: Ackers G K
The energetics of ligand-linked subunit assembly in hemoglobin require a third allosteric structure.
Biophysical chemistry 1990;37(1-3):371-82.
1990: Ackers G K; Johnson M L
Analysis of hemoglobin oxygenation from combined equilibrium and kinetic data. Is quaternary enhancement necessary?
Biophysical chemistry 1990;37(1-3):265-79.
1990: Senear D F; Ackers G K
Proton-linked contributions to site-specific interactions of lambda cI repressor and OR.
Biochemistry 1990;29(28):6568-77.
1990: Perrella M; Benazzi L; Shea M A; Ackers G K
Subunit hybridization studies of partially ligated cyanomethemoglobins using a cryogenic method. Evidence for three allosteric states.
Biophysical chemistry 1990;35(1):97-103.
1989: Brenowitz M; Senear D F; Ackers G K
Flanking DNA-sequences contribute to the specific binding of cI-repressor and OR1.
Nucleic acids research 1989;17(10):3747-55.
1987: Smith F R; Gingrich D; Hoffman B M; Ackers G K
Three-state combinatorial switching in hemoglobin tetramers: comparison between functional energetics and molecular structures.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7089-93.
1986: Brenowitz M; Senear D F; Shea M A; Ackers G K
"Footprint" titrations yield valid thermodynamic isotherms.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(22):8462-6.
1986: Senear D F; Brenowitz M; Shea M A; Ackers G K
Energetics of cooperative protein-DNA interactions: comparison between quantitative deoxyribonuclease footprint titration and filter binding.
Biochemistry 1986;25(23):7344-54.
1986: Brenowitz M; Senear D F; Shea M A; Ackers G K
Quantitative DNase footprint titration: a method for studying protein-DNA interactions.
Methods in enzymology 1986;130():132-81.
1985: Shea M A; Ackers G K
The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation.
Journal of molecular biology 1985;181(2):211-30.
1984: Kukuruzinska M A; Turner B W; Ackers G K; Roseman S
Subunit association of enzyme I of the Salmonella typhimurium phosphoenolpyruvate: glycose phosphotransferase system. Temperature dependence and thermodynamic properties.
The Journal of biological chemistry 1984;259(19):11679-81.
1984: Johnson M L; Turner B W; Ackers G K
A quantitative model for the cooperative mechanism of human hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(4):1093-7.
1983: Ackers G K; Shea M A; Smith F R
Free energy coupling within macromolecules. The chemical work of ligand binding at the individual sites in co-operative systems.
Journal of molecular biology 1983;170(1):223-42.
1983: Thillet J; Chu A H; Romeo P; Tsapis A; Ackers G K
Effects of anions on the ligand-linked subunit assembly of human hemoglobin: the mutual effects of Cl- and EDTA.
Hemoglobin 1983;7(2):141-57.
1982: Pettigrew D W; Romeo P H; Tsapis A; Thillet J; Smith M L; Turner B W; Ackers G K
Probing the energetics of proteins through structural perturbation: sites of regulatory energy in human hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(6):1849-53.
1982: Ackers G K; Johnson A D; Shea M A
Quantitative model for gene regulation by lambda phage repressor.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(4):1129-33.
1981: Chu A H; Ackers G K
Mutual effects of protons, NaCl, and oxygen on the dimer-tetramer assembly of human hemoglobin. The dimer Bohr effect.
The Journal of biological chemistry 1981;256(3):1199-205.
1981: Turner B W; Pettigrew D W; Ackers G K
Measurement and analysis of ligand-linked subunit dissociation equilibria in human hemoglobins.
Methods in enzymology 1981;76():596-628.

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