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Lina Hu

Research Profile

Chemicals & Drugs

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T-Lymphocyte Subsets

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Publications

TOP 3
Lina Hu; Joseph B Margolick; Avindra Nath; TONGGUANG WANG; Katharine A Whartenby; Hao Zhang; Anne R Gocke; Peter A Calabresi
Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.
Anne R Gocke; Inna V Grishkan; Lina Hu; Lori A Lebson; Hai M Nguyen; Katharine A Whartenby; K George Chandy; Peter A Calabresi
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
Lina Hu; Emily G Baxi; Katharine A Whartenby; Edward Knapp; Jason M Rosenzweig; Hao Zhang; Joseph B Margolick; Inna V Grishkan; Anne R Gocke; Peter A Calabresi
Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling.

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All Publications

2013: Lina Hu; Joseph B Margolick; Avindra Nath; TONGGUANG WANG; Katharine A Whartenby; Hao Zhang; Anne R Gocke; Peter A Calabresi
Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.
PloS one 2013;8(1):e54267.
2012: Anne R Gocke; Inna V Grishkan; Lina Hu; Lori A Lebson; Hai M Nguyen; Katharine A Whartenby; K George Chandy; Peter A Calabresi
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5877-86.
2012: Lina Hu; Emily G Baxi; Katharine A Whartenby; Edward Knapp; Jason M Rosenzweig; Hao Zhang; Joseph B Margolick; Inna V Grishkan; Anne R Gocke; Peter A Calabresi
Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21cip1 signaling.
The Journal of biological chemistry 2012;287(2):1261-8.
2010: TONGGUANG WANG; Myoung-Hwa Lee; Tory Johnson; Rameeza Allie; Lina Hu; Peter A Calabresi; Avindra Nath
Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(14):5020-7.
2007: Lina Hu; Michael Pennington; Qiong Jiang; Katharine A Whartenby; Peter A Calabresi
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4563-70.
2006: Katherine M Mullen; Monika Rozycka; Horea Rus; Lina Hu; Cornelia Cudrici; Ekaterina Zafranskaia; Michael Pennington; David C Johns; Susan I V Judge; Peter A Calabresi
Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system.
Annals of neurology 2006;60(1):118-27.
2005: Horea Rus; CARLOS PARDO-VILLAMIZAR; Lina Hu; Erika Darrah; Cornelia Cudrici; Teodora Niculescu; Florin Niculescu; Katherine M Mullen; Rameeza Allie; Liping Guo; Heike Wulff; Christine Beeton; Susan I V Judge; Douglas A Kerr; Hans-Günther Knaus; K George Chandy; Peter A Calabresi
The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11094-9.
2005: Rameeza Allie; Lina Hu; Katherine M Mullen; Suhayl Dhib-Jalbut; Peter A Calabresi
Bystander modulation of chemokine receptor expression on peripheral blood T lymphocytes mediated by glatiramer therapy.
Archives of neurology 2005;62(6):889-94.
2004: Lina Hu; Vishwa Deep Dixit; Valeria de Mello Coelho; Dennis D Taub
Age-associated alterations in CXCL1 chemokine expression by murine B cells.
BMC immunology 2004;5():15.
2002: Lina Hu; Louis J Rezanka; Quing Sheng Mi; Ana Lustig; Dennis D Taub; Dan Longo; James J Kenny
T15-idiotype-negative B cells dominate the phosphocholine binding cells in the preimmune repertoire of T15i knockin mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1273-80.